MCID: PRC010
MIFTS: 37

Pericardial Mesothelioma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Pericardial Mesothelioma

MalaCards integrated aliases for Pericardial Mesothelioma:

Name: Pericardial Mesothelioma 12 15 74
Malignant Mesothelioma of Pericardium 12
Malignant Pericardial Mesothelioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6201
ICD10 34 C45.2

Summaries for Pericardial Mesothelioma

MalaCards based summary : Pericardial Mesothelioma, also known as malignant mesothelioma of pericardium, is related to benign mesothelioma and tn polyagglutination syndrome. An important gene associated with Pericardial Mesothelioma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include heart, brain and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Pericardial Mesothelioma

Diseases related to Pericardial Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 benign mesothelioma 30.9 KRT7 PTGER4
2 tn polyagglutination syndrome 10.6 MUC1 MUC16
3 endometrial mucinous adenocarcinoma 10.6 MUC1 VIM
4 clear cell meningioma 10.6 MUC1 VIM
5 myxopapillary ependymoma 10.6 MUC1 VIM
6 biphasic synovial sarcoma 10.6 MUC1 VIM
7 eccrine porocarcinoma 10.6 MUC1 VIM
8 chordoid meningioma 10.6 MUC1 VIM
9 spindle cell rhabdomyosarcoma 10.5 MB MUC1
10 regional odontodysplasia 10.5 KRT19 VIM
11 pericarditis 10.4
12 papillary adenoma 10.4 KRT7 VIM
13 benign metastasizing leiomyoma 10.4 KRT7 VIM
14 bowen's disease 10.4 KRT10 KRT7
15 bladder carcinoma in situ 10.4 KRT19 KRT7
16 malignant peritoneal mesothelioma 10.4 MUC1 VIM
17 splenic tuberculosis 10.4 KRT19 SMUG1
18 thymus adenocarcinoma 10.4 KRT7 PTGER4
19 filamentary keratitis 10.4 KRT10 MUC1 MUC16
20 sternum cancer 10.4 SMUG1 VIM
21 spindle cell thymoma 10.4 MUC1 PTGER4
22 corpus luteum cyst 10.4 MUC16 SMUG1
23 jejunal adenocarcinoma 10.4 KRT7 SMUG1
24 cecal benign neoplasm 10.4 KRT7 SMUG1
25 bile duct adenoma 10.4 KRT7 MUC1
26 reticulum cell sarcoma 10.4 MUC1 S100A1 VIM
27 astroblastoma 10.4 ENO2 VIM
28 constrictive pericarditis 10.4
29 intrahepatic bile duct adenoma 10.4 KRT19 KRT7
30 polymorphous low-grade adenocarcinoma 10.4 MUC1 S100A1 VIM
31 anal gland adenocarcinoma 10.4 KRT19 KRT7
32 proliferating trichilemmal cyst 10.4 KRT19 KRT7
33 malignant epithelial mesothelioma 10.4 PTGER4 THBD
34 basal cell carcinoma, infundibulocystic 10.4 KRT10 PTGER4
35 syringocystadenoma papilliferum 10.4 MUC1 VIM
36 pilomatrix carcinoma 10.4 ENO2 MUC1
37 cystic basal cell carcinoma 10.3 KRT7 PTGER4
38 heart cancer 10.3 ERF MUC16 SMUG1
39 anus basaloid carcinoma 10.3 KRT7 PTGER4
40 solid adenocarcinoma with mucin production 10.3 KRT7 MUC1
41 head injury 10.3 ENO2 THBD
42 hidradenoma 10.3 KRT7 MUC1 VIM
43 cystadenocarcinoma 10.3 KRT7 MUC1 MUC16
44 intracranial cysts 10.3 ENO2 MUC1
45 anus adenocarcinoma 10.3 KRT19 KRT7
46 malignant syringoma 10.3 KRT7 PTGER4
47 malignant peripheral nerve sheath tumor 10.3 MUC1 S100A1 VIM
48 parachordoma 10.3 KRT7 MUC1 VIM
49 secretory meningioma 10.3 KRT7 MUC1 VIM
50 monophasic synovial sarcoma 10.3 KRT7 MUC1 VIM

Graphical network of the top 20 diseases related to Pericardial Mesothelioma:



Diseases related to Pericardial Mesothelioma

Symptoms & Phenotypes for Pericardial Mesothelioma

GenomeRNAi Phenotypes related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

27 (show all 29)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.19 ERF
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.19 ERF VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.19 ERF
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.19 GFPT1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.19 GFPT1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.19 ERF GFPT1 KRT19 VIM
7 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.19 KRT19
8 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.19 GFPT1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.19 VIM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.19 KRT19 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.19 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.19 VIM
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.19 GFPT1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.19 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.19 GFPT1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.19 VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.19 ERF
18 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.19 KRT19
19 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.19 GFPT1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.19 ERF
21 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.19 GFPT1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.19 VIM
23 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.19 GFPT1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.19 ERF
25 Increased shRNA abundance (Z-score > 2) GR00366-A-76 10.19 GFPT1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-77 10.19 ERF KRT19
27 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.19 ERF
28 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.19 VIM
29 Negative genetic interaction between PTEN-/- and PTEN+/+ GR00255-A-3 9.1 CD99 ENO2 KRT10 MPO SMUG1 THBD

MGI Mouse Phenotypes related to Pericardial Mesothelioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 ERF KRT19 MAPK1 MB MPO PECAM1
2 cellular MP:0005384 9.93 ENO2 ERF KRT19 KRT7 MAPK1 MB
3 muscle MP:0005369 9.5 MAPK1 MB MPO PECAM1 PTGER4 S100A1
4 respiratory system MP:0005388 9.23 ENO2 MAPK1 MB PECAM1 PTGER4 S100A1

Drugs & Therapeutics for Pericardial Mesothelioma

Search Clinical Trials , NIH Clinical Center for Pericardial Mesothelioma

Genetic Tests for Pericardial Mesothelioma

Anatomical Context for Pericardial Mesothelioma

MalaCards organs/tissues related to Pericardial Mesothelioma:

42
Heart, Brain, Liver, Bone

Publications for Pericardial Mesothelioma

Articles related to Pericardial Mesothelioma:

(show top 50) (show all 129)
# Title Authors Year
1
Pericardial Mesothelioma in a 35-Year-Old Male With Ulcerative Colitis. ( 30632392 )
2019
2
Case Report of Aggressive Primary Pericardial Mesothelioma Presenting as a Constrictive Pericarditis. ( 30841705 )
2019
3
Primary pericardial mesothelioma presenting as constrictive pericarditis. ( 30624613 )
2019
4
Treatment and Outcomes of Primary Pericardial Mesothelioma: A Contemporary Review of 103 Published Cases. ( 30594459 )
2019
5
Sudden cardiac death due to primary malignant pericardial mesothelioma: Brief report and literature review. ( 30705816 )
2019
6
Echocardiographic characteristics of primary malignant pericardial mesothelioma and outcomes analysis: a retrospective study. ( 29695235 )
2018
7
<sup>18</sup>F-fluorodeoxyglucose imaging of primary malignant pericardial mesothelioma with concurrent pericardial and pleural effusions and bone metastasis: A case report. ( 29805789 )
2018
8
The Antemortem Diagnosis of Primary Malignant Pericardial Mesothelioma: A Multidisciplinary Evaluation. ( 29709931 )
2018
9
Recurrence of Pericardial Mesothelioma Affecting the Myocardium after Pericardial Resection. ( 29792828 )
2018
10
Pericardial mesothelioma presenting as chronic constrictive pericarditis. A series of three cases from a single institution. ( 30303153 )
2018
11
Localized primary malignant pericardial mesothelioma. ( 30450660 )
2018
12
Pericardial mesothelioma presenting as a suspected ST-elevation myocardial infarction. ( 28343785 )
2017
13
A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report. ( 28351431 )
2017
14
Primary pericardial mesothelioma and asbestos exposure: a rare fatal disease. ( 28500034 )
2017
15
Malignant pericardial mesothelioma : AA systematic review of current practice. ( 28130567 )
2017
16
Primary pericardial mesothelioma in a 48-year-old patient. ( 29171839 )
2017
17
Pericardial mesothelioma. ( 27318362 )
2016
18
F-18 FDG PET/CT images of a rare primer cardiac tumour: Primary Pericardial Mesothelioma. ( 27515105 )
2016
19
Positive response of a primary malignant pericardial mesothelioma to pemetrexed plus cisplatin followed by pemetrexed maintenance chemotherapy: A case report. ( 27347127 )
2016
20
Primary malignant pericardial mesothelioma with increased serum mesothelin diagnosed by surgical pericardial resection: A case report. ( 27900083 )
2016
21
Sarcomatoid Type Primary Pericardial Mesothelioma with a Long-term Survival after the Onset of Cardiac Tamponade. ( 27803412 )
2016
22
Pericardial Effusion due to Primary Malignant Pericardial Mesothelioma: A Common Finding but an Uncommon Cause. ( 28003826 )
2016
23
Primary pericardial mesothelioma presenting as multiple pericardial masses on CT. ( 30364446 )
2016
24
Pericardial Mesothelioma in a Yellow-naped Amazon Parrot ( Amazona auropalliata ). ( 25867668 )
2015
25
Successful palliation for an aged patient with primary pericardial mesothelioma. ( 26376726 )
2015
26
Endobronchial ultrasound-guided transbronchial needle aspiration in a patient with pericardial mesothelioma. ( 25742892 )
2015
27
A rare cause of heart failure with preserved ejection fraction: primary pericardial mesothelioma masquerading as pericardial constriction. ( 24654246 )
2014
28
Primary malignant pericardial mesothelioma-a rare cause of superior vena cava thrombosis and constrictive pericarditis. ( 25590007 )
2014
29
A rare case of primary malignant pericardial mesothelioma. ( 25250196 )
2014
30
Primary pericardial mesothelioma: A rare cause of constrictive pericarditis. ( 24887935 )
2013
31
Three-year survival after surgery for primary malignant pericardial mesothelioma: report of a case. ( 23408086 )
2013
32
Mixed form of pericardial mesothelioma with osseous differentiation in a dog. ( 23578582 )
2013
33
Primary pericardial mesothelioma: a rare entity. ( 23840993 )
2013
34
Cardiac MRI findings in a dog with a diffuse pericardial mesothelioma and pericardial effusion. ( 24051256 )
2013
35
Primary pericardial mesothelioma in a 19-year-old presenting as pericarditis. ( 23353042 )
2013
36
Primary sarcomatoid malignant pericardial mesothelioma. ( 23291695 )
2013
37
Fluorine-18 fluoro-2-deoxyglucose positron emission tomography/computed tomography in a case of suspected primary pericardial mesothelioma. ( 23919083 )
2012
38
Unexpected malignant pericardial mesothelioma presenting as pericardial constriction. ( 23094904 )
2012
39
Primary malignant pericardial mesothelioma presenting as acute pericarditis. ( 22509441 )
2012
40
Primary pericardial mesothelioma unique case and literature review. ( 22740748 )
2012
41
A case report of an extremely rare and aggressive tumor: primary malignant pericardial mesothelioma. ( 22826778 )
2012
42
A case of primary pericardial mesothelioma detected by 18F-FDG PET/CT. ( 22475912 )
2012
43
False aneurysm of ascending aorta due to pericardial mesothelioma. ( 22593561 )
2012
44
Pericardial mesothelioma and asbestos exposure. ( 21156353 )
2011
45
Malignant pericardial mesothelioma. ( 20643560 )
2011
46
A case of malignant pericardial mesothelioma with constrictive pericarditis physiology misdiagnosed as pericardial metastatic cancer. ( 21779289 )
2011
47
Primary malignant pericardial mesothelioma presenting as effusive-constrictive pericarditis. ( 21828406 )
2011
48
Primary pericardial mesothelioma in an asbestos-exposed patient with previous heart surgery. ( 20530447 )
2010
49
Primary malignant pericardial mesothelioma mimicking pericardial metastasis from adenocarcinoma. ( 21102264 )
2010
50
Malignant pericardial mesothelioma following thoracal radiotherapy; dissemination from pericardium to pleura. ( 21038142 )
2010

Variations for Pericardial Mesothelioma

Expression for Pericardial Mesothelioma

Search GEO for disease gene expression data for Pericardial Mesothelioma.

Pathways for Pericardial Mesothelioma

Pathways related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 KRT10 KRT19 KRT7 MUC1 VIM
2
Show member pathways
11.17 KRT19 KRT7 VIM
3 10.41 MAPK1 VIM

GO Terms for Pericardial Mesothelioma

Cellular components related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 ENO2 KRT10 MPO MSLN MUC1 MUC16
2 extracellular exosome GO:0070062 9.36 ENO2 GFPT1 KRT10 KRT19 KRT7 MB
3 intermediate filament GO:0005882 9.26 KRT10 KRT19 KRT7 VIM

Biological processes related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.43 KRT10 KRT19 KRT7
2 regulation of ossification GO:0030278 9.16 MAPK1 PTGER4
3 Bergmann glial cell differentiation GO:0060020 8.96 MAPK1 VIM
4 response to lipopolysaccharide GO:0032496 8.92 MAPK1 MPO PTGER4 THBD

Sources for Pericardial Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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