MCID: PRC005
MIFTS: 35

Pericardial Tuberculosis

Categories: Infectious diseases

Aliases & Classifications for Pericardial Tuberculosis

MalaCards integrated aliases for Pericardial Tuberculosis:

Name: Pericardial Tuberculosis 12 15
Pericarditis, Tuberculous 44 73
Tuberculous Pericarditis 12
Pericarditis Tuberculous 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4962
ICD10 33 A18.84
MeSH 44 D010495
SNOMED-CT 68 67256000
UMLS 73 C0031049

Summaries for Pericardial Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that is located in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

MalaCards based summary : Pericardial Tuberculosis, also known as pericarditis, tuberculous, is related to pericardium cancer and abdominal tuberculosis. An important gene associated with Pericardial Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Epstein-Barr virus infection and NF-kappaB Signaling. The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include pericardium, liver and bone, and related phenotypes are immune system and neoplasm

Related Diseases for Pericardial Tuberculosis

Diseases related to Pericardial Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 pericardium cancer 30.2 PTGER4 SMUG1
2 abdominal tuberculosis 10.9 ADA TBP
3 sporotrichosis 10.7 IFNG IL10
4 baylisascariasis 10.7 IFNG IL10
5 cryptococcal meningitis 10.7 ADA IFNG
6 chronic graft versus host disease 10.6 IFNG IL10
7 tuberculoid leprosy 10.6 IFNG IL10
8 adult lymphoma 10.6 CABIN1 SMUG1
9 clonorchiasis 10.6 IFNG IL10
10 chronic active epstein-barr virus infection 10.6 IFNG IL10
11 multicentric castleman disease 10.6 IFNG IL10
12 fascioliasis 10.6 IFNG IL10
13 secondary hypertrophic osteoarthropathy 10.6 POMC SMUG1
14 primary systemic mycosis 10.6 IFNG IL10
15 laryngeal tuberculosis 10.6 POMC SMUG1
16 poliomyelitis 10.6 IFNG IL10
17 pleural tuberculosis 10.6 ADA IFNG TBP
18 hand, foot and mouth disease 10.6 IFNG IL10
19 pericarditis 10.6
20 testicular leydig cell tumor 10.6 POMC SMUG1
21 intermediate uveitis 10.5 IFNG IL10
22 epididymis cancer 10.5 CEACAM5 PTGER4
23 epididymis adenocarcinoma 10.5 CEACAM5 PTGER4
24 peanut allergy 10.5 IFNG IL10
25 orofacial granulomatosis 10.5 IFNG IL10
26 liver lymphoma 10.5 CEACAM5 SMUG1
27 splenic tuberculosis 10.5 CEACAM5 SMUG1
28 coccidiosis 10.5 IFNG IL10
29 gallbladder squamous cell carcinoma 10.5 CEACAM5 SMUG1
30 lymphohistiocytoid mesothelioma 10.5 CEACAM5 PTGER4
31 malignant spiradenoma 10.5 CEACAM5 SMUG1
32 eales disease 10.5 IFNG IL10
33 nodular hidradenoma 10.5 CEACAM5 PTGER4
34 thymus adenocarcinoma 10.5 CEACAM5 PTGER4
35 hemorrhagic fever 10.5 IFNG IL10
36 gastric signet ring cell adenocarcinoma 10.5 CEACAM5 SMUG1
37 rete testis adenocarcinoma 10.5 CEACAM5 PTGER4
38 eccrine adenocarcinoma 10.5 CEACAM5 SMUG1
39 spotted fever 10.4 IFNG IL10
40 granulomatous myositis 10.4 PRTN3 SMUG1
41 primary bacterial infectious disease 10.4 ADA IFNG IL10
42 femoral neuropathy 10.4 CEACAM5 SMUG1
43 meningitis 10.4 ADA IFNG IL10
44 pulmonary tuberculosis 10.4 ADA IFNG IL10
45 omenn syndrome 10.4 ADA IFNG IL10
46 visceral leishmaniasis 10.4 ADA IFNG IL10
47 rete testis neoplasm 10.4 CEACAM5 PTGER4
48 immune deficiency disease 10.4 ADA IFNG IL10
49 mycobacterium tuberculosis 1 10.4 ADA IFNG IL10
50 descending colon cancer 10.4 CEACAM5 SMUG1

Graphical network of the top 20 diseases related to Pericardial Tuberculosis:



Diseases related to Pericardial Tuberculosis

Symptoms & Phenotypes for Pericardial Tuberculosis

MGI Mouse Phenotypes related to Pericardial Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.56 ADA CABIN1 IFNG IL10 POMC PRTN3
2 neoplasm MP:0002006 9.02 IFNG IL10 POMC PTGER4 SMUG1

Drugs & Therapeutics for Pericardial Tuberculosis

Drugs for Pericardial Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3 Prednisolone acetate Phase 3
4 glucocorticoids Phase 3
5 Methylprednisolone acetate Phase 3
6 Methylprednisolone Hemisuccinate Phase 3
7 Gastrointestinal Agents Phase 3
8 Neuroprotective Agents Phase 3
9 Hormone Antagonists Phase 3
10 Hormones Phase 3
11 Vaccines Phase 3
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
13 Peripheral Nervous System Agents Phase 3
14 Prednisolone hemisuccinate Phase 3
15 Prednisolone phosphate Phase 3
16 Antiemetics Phase 3
17 Protective Agents Phase 3
18 Anti-Inflammatory Agents Phase 3
19 Autonomic Agents Phase 3
20 Antineoplastic Agents, Hormonal Phase 3
21 Fibrinolytic Agents Phase 3
22 Tissue Plasminogen Activator Phase 3
23 Plasminogen Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis Completed NCT00810849 Phase 3 Prednisolone
2 IMPI 2 - A Trial of Intrapericardial Alteplase in Large Pericardial Effusion Recruiting NCT02673879 Phase 3

Search NIH Clinical Center for Pericardial Tuberculosis

Cochrane evidence based reviews: pericarditis, tuberculous

Genetic Tests for Pericardial Tuberculosis

Anatomical Context for Pericardial Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Pericardial Tuberculosis:

19
Pericardium

MalaCards organs/tissues related to Pericardial Tuberculosis:

41
Liver, Bone, Bone Marrow

Publications for Pericardial Tuberculosis

Articles related to Pericardial Tuberculosis:

(show all 14)
# Title Authors Year
1
Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study. ( 29750184 )
2018
2
A primary intestinal lymphangiectasia hiding the diagnosis of pleural and pericardial tuberculosis: a clinical observation. ( 28491220 )
2017
3
Diffuse pseudo-tumoral pericardial tuberculosis. ( 28065910 )
2017
4
Immune thrombocytopenia associated with pleural and pericardial tuberculosis: case report. ( 27208577 )
2016
5
Pericardial tuberculosis with an emphasis on empiric therapy in endemic areas for tuberculosis (a case report). ( 27847027 )
2016
6
Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis. ( 26870790 )
2015
7
A Compartmentalized Profibrotic Immune Response Characterizes Pericardial Tuberculosis, Irrespective of HIV-1 Infection. ( 26669475 )
2015
8
Comprehensive cardiovascular magnetic resonance for monitoring the response to therapy in pericardial tuberculosis. ( 24286735 )
2013
9
Pericardial tuberculosis. ( 23843490 )
2013
10
Persistent pyrexia post-liver transplantation: a unique case of pericardial tuberculosis. ( 19046713 )
2008
11
Detection of Mycobacterium tuberculosis complex DNA in pericardial fluid, bone marrow and peripheral blood in a patient with pericardial tuberculosis. A case report. ( 11578792 )
2001
12
Serodiagnosis of pericardial tuberculosis. ( 7796085 )
1995
13
Utility of scalene node biopsy in the diagnosis of pleuro-pericardial tuberculosis. ( 4448816 )
1974
14
Pleural, peritoneal, and pericardial tuberculosis; a review of 209 cases uncomplicated by treatment or secondary infection. ( 15413770 )
1950

Variations for Pericardial Tuberculosis

Expression for Pericardial Tuberculosis

Search GEO for disease gene expression data for Pericardial Tuberculosis.

Pathways for Pericardial Tuberculosis

Pathways related to Pericardial Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.85 IFNG IL10 TBP
2 11.54 CABIN1 CEACAM5 IFNG IL10 TRIM25
3 11.4 CEACAM5 IFNG IL10
4 11.05 IFNG POMC TBP
5 10.8 IFNG IL10
6 10.67 IFNG IL10

GO Terms for Pericardial Tuberculosis

Biological processes related to Pericardial Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytokine secretion GO:0050715 8.96 IL10 PTGER4
2 negative regulation of inflammatory response GO:0050728 8.8 ADA IL10 PTGER4

Sources for Pericardial Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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