MCID: PRC005
MIFTS: 33

Pericardial Tuberculosis

Categories: Cardiovascular diseases, Infectious diseases

Aliases & Classifications for Pericardial Tuberculosis

MalaCards integrated aliases for Pericardial Tuberculosis:

Name: Pericardial Tuberculosis 12 15 17
Pericarditis, Tuberculous 44 70
Tuberculous Pericarditis 12
Pericarditis Tuberculous 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4962
MeSH 44 D010495
SNOMED-CT 67 67256000
ICD10 32 A18.84
UMLS 70 C0031049

Summaries for Pericardial Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that is located in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

MalaCards based summary : Pericardial Tuberculosis, also known as pericarditis, tuberculous, is related to pericarditis and pulmonary tuberculosis. An important gene associated with Pericardial Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and Th1 Differentiation Pathway. The drugs Prednisolone acetate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include pericardium and bone marrow.

Related Diseases for Pericardial Tuberculosis

Diseases related to Pericardial Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 439)
# Related Disease Score Top Affiliating Genes
1 pericarditis 30.5 IFNG CRP ADA
2 pulmonary tuberculosis 30.3 IL10 IFNG ADA
3 pericardial effusion 30.3 CRP CD4 ADA
4 pleurisy 30.2 IFNG CRP ADA
5 mycobacterium tuberculosis 1 30.2 IL10 IFNG CD4 ADA
6 pleural empyema 30.1 CRP CD4 ADA
7 cardiac tamponade 30.0 CRP ADA
8 pleural tuberculosis 30.0 TBP IFNG CD4 ADA
9 pericardium cancer 29.9 CEACAM5 CALB2
10 herpes zoster 29.8 IL10 IFNG CD4
11 lymphopenia 29.8 IL10 IFNG ADA
12 bronchopneumonia 29.7 IL10 CRP CD4
13 thrombocytopenia due to platelet alloimmunization 29.7 IL10 CD4
14 extrapulmonary tuberculosis 29.7 IL10 IFNG CRP ADA
15 miliary tuberculosis 29.6 IFNG CRP CD4 ADA
16 constrictive pericarditis 29.6 IFNG CRP CALB2 ADA
17 human immunodeficiency virus type 1 29.5 IL10 IFNG CD4 ADA
18 meningitis 29.5 IL10 IFNG CRP ADA
19 acquired immunodeficiency syndrome 29.1 IL10 IFNG CRP CD4 ADA
20 immune deficiency disease 28.8 TBP IL10 IFNG CRP CD4 ADA
21 tuberculous empyema 10.3 TBP ADA
22 necrotic uveal melanoma 10.3 IFNG CD4
23 ocular tuberculosis 10.3 IFNG CD4
24 central nervous system tuberculosis 10.3 CD4 ADA
25 penicilliosis 10.3 IFNG CD4
26 skin sarcoidosis 10.3 IFNG CD4
27 petrositis 10.3 IFNG CRP
28 retinitis pigmentosa 46 10.2 IFNG CD4
29 uveoparotid fever 10.2 IFNG CD4
30 skeletal tuberculosis 10.2 IFNG CRP
31 soft tissue sarcoma 10.2 IFNG CRP
32 pleural lipoma 10.2 CEACAM5 ADA
33 strongyloidiasis 10.2 IFNG CD4
34 spotted fever 10.2 IL10 IFNG
35 spotted fever rickettsiosis 10.2 IL10 IFNG
36 rheumatoid arthritis interstitial lung disease 10.2 CRP CD4
37 epidural abscess 10.2 CRP CD4
38 atrophoderma vermiculata 10.2 IFNG CEACAM5
39 primary syphilis 10.2 CRP CD4
40 urogenital tuberculosis 10.2 CRP CD4
41 chronic graft versus host disease 10.2 IL10 IFNG
42 breast abscess 10.2 CRP CD4
43 meningovascular neurosyphilis 10.2 CRP CD4
44 pyomyositis 10.2 CRP CD4
45 splenic abscess 10.2 CRP CD4
46 orbital cellulitis 10.2 CRP CD4
47 cellulitis 10.2 CRP CD4
48 acute orbital inflammation 10.2 CRP CD4
49 neuroretinitis 10.2 CRP CD4
50 mediastinitis 10.2 CRP CD4

Graphical network of the top 20 diseases related to Pericardial Tuberculosis:



Diseases related to Pericardial Tuberculosis

Symptoms & Phenotypes for Pericardial Tuberculosis

Drugs & Therapeutics for Pericardial Tuberculosis

Drugs for Pericardial Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
6
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
7 Fibrinolytic Agents Phase 3
8 Plasminogen Phase 3
9 Tissue Plasminogen Activator Phase 3
10 Methylprednisolone Acetate Phase 3
11 Hormone Antagonists Phase 3
12 glucocorticoids Phase 3
13 Hormones Phase 3
14 Antineoplastic Agents, Hormonal Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Vaccines Phase 3
17
Rifampicin Approved Phase 2 13292-46-1 5381226 5458213
18 Antibiotics, Antitubercular Phase 2
19 Antitubercular Agents Phase 2
20 Anti-Infective Agents Phase 2
21 Anti-Bacterial Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis Unknown status NCT02673879 Phase 3
2 A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis Completed NCT00810849 Phase 3 Prednisolone
3 IMPI-3 - A Randomized Controlled Trial of High vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis Not yet recruiting NCT04521803 Phase 2 high dose Rifampicin (RIF)

Search NIH Clinical Center for Pericardial Tuberculosis

Cochrane evidence based reviews: pericarditis, tuberculous

Genetic Tests for Pericardial Tuberculosis

Anatomical Context for Pericardial Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Pericardial Tuberculosis:

19
Pericardium

MalaCards organs/tissues related to Pericardial Tuberculosis:

40
Bone Marrow

Publications for Pericardial Tuberculosis

Articles related to Pericardial Tuberculosis:

(show top 50) (show all 72)
# Title Authors PMID Year
1
The role of histopathology in establishing the diagnosis of tuberculous pericardial effusions in the presence of HIV. 61 54
16430476 2006
2
The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis. 61 54
12226030 2002
3
The diagnostic and prognostic value of adenosine deaminase in tuberculous pericarditis. 54 61
8665976 1995
4
A case of tuberculous pericarditis--use of adenosine deaminase activity (ADA) in early diagnosis. 54 61
2228912 1990
5
Aftermath of pulmonary tuberculosis: computed tomography assessment. 61
32322321 2020
6
Tricuspid Valve Regurgitation in Patients Undergoing Pericardiectomy for Constrictive Pericarditis. 61
32387779 2020
7
Epidemiological characteristics and some risk factors of extrapulmonary tuberculosis in Larache, Morocco. 61
33235658 2020
8
[CME: Extrapulmonary Tuberculosis]. 61
31771497 2019
9
A clinical case of tuberculosis with transient constrictive pericarditis and perimyocarditis. 61
31413861 2019
10
Identification of risk factors and diagnostic methodology in serositis by M. tuberculosis 61
30521739 2018
11
Corticosteroids as an adjunct to tuberculosis therapy. 61
30138039 2018
12
Pericardial hydatid cyst and tuberculosis co-existence. 61
32082754 2018
13
Nocardia beijingensis pericarditis presenting with cardiac tamponade: A case report. 61
29059035 2018
14
Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study. 61
29750184 2018
15
Suspected Pericardial Tuberculosis Revealed as an Amyloid Pericardial Mass. 61
30416832 2018
16
Diffuse pseudo-tumoral pericardial tuberculosis. 61
28065910 2017
17
A primary intestinal lymphangiectasia hiding the diagnosis of pleural and pericardial tuberculosis: a clinical observation. 61
28491220 2017
18
Pericardial tuberculosis with an emphasis on empiric therapy in endemic areas for tuberculosis (a case report). 61
27847027 2016
19
Immune thrombocytopenia associated with pleural and pericardial tuberculosis: case report. 61
27208577 2016
20
[Effusive pericarditis: clinical and etiological aspects in Lomé]. 61
26947626 2016
21
[Multifocal tuberculosis in immunocompetent patients]. 61
27583077 2016
22
A Compartmentalized Profibrotic Immune Response Characterizes Pericardial Tuberculosis, Irrespective of HIV-1 Infection. 61
26669475 2015
23
Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis. 61
26870790 2015
24
[An uncommon detection of Mycobacterium tuberculosis in pericardial effusion]. 61
25523224 2014
25
Comprehensive cardiovascular magnetic resonance for monitoring the response to therapy in pericardial tuberculosis. 61
24286735 2014
26
Pericardial tuberculosis. 61
23843490 2013
27
[Pericardial tuberculosis is still an important differential diagnosis in Denmark]. 61
23608014 2013
28
Images in cardiovascular medicine: tuberculous aortitis. 61
22864122 2012
29
Alemtuzumab induction in deceased donor kidney transplantation. 61
21839271 2011
30
Tuberculosis pericarditis with cardiac tamponade: management in the resource-limited setting. 61
21118941 2010
31
Cardiac manifestations of HIV infection: an African perspective. 61
19104517 2009
32
Persistent pyrexia post-liver transplantation: a unique case of pericardial tuberculosis. 61
19046713 2008
33
A case of cardiac tamponade caused by tuberculous pericarditis. 54
19155666 2008
34
Resolution of nodular myocardial tuberculosis demonstrated by contrast-enhanced magnetic resonance imaging. 61
18776963 2008
35
Contemporary use of adjunctive corticosteroids in tuberculous pericarditis. 61
17445921 2008
36
A modern approach to tuberculous pericarditis. 61
17976506 2007
37
[Bone and joint tuberculosis concurrent with tuberculosis of other organs]. 61
17633120 2007
38
The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis. 54
17625694 2007
39
Constrictive pericarditis: detection of mycobacterium tuberculosis in paraffin-embedded pericardial tissues by polymerase chain reaction. 61
17303104 2007
40
The management of tuberculous pericardial effusion: experience in 233 consecutive patients. 61
17392991 2007
41
Adenosine deaminase and tuberculous pericarditis--a systematic review with meta-analysis. 54
16950165 2006
42
Characterization of the immunological features of tuberculous pericardial effusions in HIV positive and HIV negative patients in contrast with non-tuberculous effusions. 61
16360340 2006
43
Tuberculous pericarditis. 54
16330703 2005
44
Adenosine deaminase activity--more than a diagnostic tool in tuberculous pericarditis. 54
16049586 2005
45
Video-assisted thoracoscopic pericardial fenestration for tuberculous pericardial effusion. 54
14997974 2004
46
[A case of tuberculous pericarditis, the diagnosis of which was complicated by the delay in the rise of adenosine deaminase in the pericardial effusion]. 54
12806984 2003
47
[A case of primary malignant cardiac tumour considered as a pericardial tuberculosis]. 61
12626319 2003
48
Comparison of polymerase chain reaction with adenosine deaminase activity in pericardial fluid for the diagnosis of tuberculous pericarditis. 54
12427503 2002
49
Tubercular pseudoaneurysms of aorta. 61
11603443 2001
50
Detection of Mycobacterium tuberculosis complex DNA in pericardial fluid, bone marrow and peripheral blood in a patient with pericardial tuberculosis. A case report. 61
11578792 2001

Variations for Pericardial Tuberculosis

Expression for Pericardial Tuberculosis

Search GEO for disease gene expression data for Pericardial Tuberculosis.

Pathways for Pericardial Tuberculosis

GO Terms for Pericardial Tuberculosis

Biological processes related to Pericardial Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell activation GO:0050870 9.32 CD4 ADA
2 macrophage differentiation GO:0030225 9.26 IFNG CD4
3 positive regulation of calcium-mediated signaling GO:0050850 9.16 CD4 ADA
4 positive regulation of signaling receptor activity GO:2000273 8.96 IL10 IFNG
5 positive regulation of MHC class II biosynthetic process GO:0045348 8.62 IL10 IFNG

Sources for Pericardial Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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