MCID: PRC005
MIFTS: 39

Pericardial Tuberculosis

Categories: Cardiovascular diseases, Infectious diseases
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Aliases & Classifications for Pericardial Tuberculosis

MalaCards integrated aliases for Pericardial Tuberculosis:

Name: Pericardial Tuberculosis 11 14 16
Pericarditis, Tuberculous 43 71
Tuberculous Pericarditis 11 75
Pericarditis Tuberculous 53

Classifications:



External Ids:

Disease Ontology 11 DOID:4962
MeSH 43 D010495
SNOMED-CT 68 67256000
UMLS 71 C0031049

Summaries for Pericardial Tuberculosis

Disease Ontology: 11 An extrapulmonary tuberculosis that is located in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

MalaCards based summary: Pericardial Tuberculosis, also known as pericarditis, tuberculous, is related to cardiac tamponade and pleural empyema. An important gene associated with Pericardial Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are 4-1BB Pathway and T-cell activation SARS-CoV-2. The drugs Plasminogen and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include pericardium, heart and lung.

Wikipedia: 75 Tuberculous pericarditis is a form of... more...

Related Diseases for Pericardial Tuberculosis

Diseases related to Pericardial Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 579)
# Related Disease Score Top Affiliating Genes
1 cardiac tamponade 30.3 CRP ADA
2 pleural empyema 30.1 CRP CD4 ADA
3 pericardial mesothelioma 29.9 CEACAM5 CALB2
4 pericardium cancer 29.9 CEACAM5 CALB2
5 pericarditis 29.9 TNF IFNG CRP ADA
6 constrictive pericarditis 29.9 IFNG CRP CALB2 ADA
7 pulmonary tuberculosis 29.8 TNF IFNG CRP ADA
8 benign mesothelioma 29.8 CEACAM5 CALB2
9 pericardial effusion 29.7 TNF CRP CD4 ADA
10 histoplasmosis 29.5 TNF IFNG CD4
11 bronchopneumonia 29.5 TNF CRP CD4
12 pleurisy 29.5 TNF IFNG CRP ADA
13 alcohol use disorder 29.4 TNF CRP CD4
14 mycobacterium tuberculosis 1 29.3 TNF IFNG CRP CD4 ADA
15 meningitis 29.3 TNF IFNG CRP ADA
16 fungal infectious disease 29.2 TNF IFNG CRP CD4
17 crohn's disease 29.2 TNF IFNG CRP CD4
18 malaria 29.1 TNF IFNG CRP CD4 ADA
19 miliary tuberculosis 28.9 TNF IFNG CRP CD4 ADA
20 acquired immunodeficiency syndrome 28.9 TNF IFNG CRP CD4 ADA
21 pleural tuberculosis 28.7 TNF TBP IFNG CRP CEACAM5 CD4
22 immune deficiency disease 28.6 TNF TBP IFNG CRP CD4 ADA
23 extrapulmonary tuberculosis 28.5 TNF TBP IFNG CRP CEACAM5 CD4
24 bladder tuberculosis 10.2 IFNG ADA
25 sarcoid meningitis 10.2 IFNG ADA
26 human immunodeficiency virus type 1 10.2
27 ocular tuberculosis 10.2 IFNG CD4
28 latent syphilis 10.2 IFNG CD4
29 necrotizing ulcerative gingivitis 10.2 IFNG CD4
30 penicilliosis 10.2 IFNG CD4
31 tick infestation 10.2 TBP CD4
32 ventilation pneumonitis 10.2 CRP CD4
33 syphilitic meningitis 10.2 CRP CD4
34 berylliosis 10.2 IFNG CD4
35 multiple cranial nerve palsy 10.2 CRP CD4
36 intracranial abscess 10.2 CRP CD4
37 purulent endophthalmitis 10.2 CRP CD4
38 cavernous sinus thrombosis 10.2 CRP CD4
39 pyomyositis 10.2 CRP CD4
40 acalculous cholecystitis 10.2 CRP CD4
41 granulomatous angiitis 10.2 CRP CD4
42 breast abscess 10.2 CRP CD4
43 orbital cellulitis 10.2 CRP CD4
44 acute orbital inflammation 10.2 CRP CD4
45 phagocyte bactericidal dysfunction 10.2 IFNG ADA
46 beta-lactam allergy 10.2 CRP CD4
47 congenital syphilis 10.2 CRP CD4
48 mediastinitis 10.2 CRP CD4
49 mikulicz disease 10.2 CRP CD4
50 acute interstitial pneumonia 10.2 CRP CD4

Graphical network of the top 20 diseases related to Pericardial Tuberculosis:



Diseases related to Pericardial Tuberculosis

Symptoms & Phenotypes for Pericardial Tuberculosis

Drugs & Therapeutics for Pericardial Tuberculosis

Drugs for Pericardial Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Plasminogen Approved Phase 3 9001-91-6
2
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
3
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
4
Prednisolone Approved, Vet_approved Phase 3 50-24-8 4894 5755
5
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5 1875
6
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 4159 6741
7
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7 4897
8 Fibrinolytic Agents Phase 3
9 Tissue Plasminogen Activator Phase 3
10 Antineoplastic Agents, Hormonal Phase 3
11 Vaccines Phase 3
12 Hormones Phase 3
13 Hormone Antagonists Phase 3
14 glucocorticoids Phase 3
15 Anti-Inflammatory Agents Phase 3
16
Methylprednisolone Acetate Phase 3 584547
17
Rifampicin Approved Phase 2 13292-46-1 135512673 5381226 135900090
18 Anti-Bacterial Agents Phase 2
19 Anti-Infective Agents Phase 2
20 Antitubercular Agents Phase 2
21 Antibiotics, Antitubercular Phase 2
22 Radiopharmaceuticals
23 Fluorodeoxyglucose F18

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis Unknown status NCT02673879 Phase 3
2 A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis Completed NCT00810849 Phase 3 Prednisolone
3 IMPI-3 - A Randomized Controlled Trial of High vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis Recruiting NCT04521803 Phase 2 high dose Rifampicin (RIF)
4 18F-FDG PET/CT in the Diagnosis of Tuberculous Pericarditis Completed NCT05458089

Search NIH Clinical Center for Pericardial Tuberculosis

Cochrane evidence based reviews: pericarditis, tuberculous

Genetic Tests for Pericardial Tuberculosis

Anatomical Context for Pericardial Tuberculosis

Organs/tissues related to Pericardial Tuberculosis:

FMA: Pericardium
MalaCards : Heart, Lung, Bone Marrow, T Cells, Liver, Bone, Kidney

Publications for Pericardial Tuberculosis

Articles related to Pericardial Tuberculosis:

(show top 50) (show all 596)
# Title Authors PMID Year
1
A case of cardiac tamponade caused by tuberculous pericarditis. 53 62
19155666 2008
2
The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis. 53 62
17625694 2007
3
Adenosine deaminase and tuberculous pericarditis--a systematic review with meta-analysis. 53 62
16950165 2006
4
The role of histopathology in establishing the diagnosis of tuberculous pericardial effusions in the presence of HIV. 53 62
16430476 2006
5
Tuberculous pericarditis. 53 62
16330703 2005
6
Adenosine deaminase activity--more than a diagnostic tool in tuberculous pericarditis. 53 62
16049586 2005
7
Video-assisted thoracoscopic pericardial fenestration for tuberculous pericardial effusion. 53 62
14997974 2004
8
[A case of tuberculous pericarditis, the diagnosis of which was complicated by the delay in the rise of adenosine deaminase in the pericardial effusion]. 53 62
12806984 2003
9
Comparison of polymerase chain reaction with adenosine deaminase activity in pericardial fluid for the diagnosis of tuberculous pericarditis. 53 62
12427503 2002
10
The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis. 53 62
12226030 2002
11
Relevance of adenosine deaminase and lysozyme measurements in the diagnosis of tuberculous pericarditis. 53 62
11173777 2000
12
The diagnostic and prognostic value of adenosine deaminase in tuberculous pericarditis. 53 62
8665976 1995
13
[Surgical intervention to tuberculous pericarditis: a case report]. 53 62
7967260 1994
14
Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis. 53 62
8205688 1994
15
Tuberculous pericarditis: importance of adenosine deaminase activity in pericardial fluid. 53 62
8312671 1993
16
[Tuberculous pericarditis: value of adenosine deaminase activity level assessment]. 53 62
1439386 1992
17
[Tuberculous pericarditis: diagnostic value of adenosine deaminase]. 53 62
1828568 1991
18
A case of tuberculous pericarditis--use of adenosine deaminase activity (ADA) in early diagnosis. 53 62
2228912 1990
19
Fungal esophagitis associated with tuberculous pericarditis in an human immunodeficiency virus-positive patient: a case report. 62
36345027 2022
20
Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report. 62
36429861 2022
21
"Ghost imaging" in pericardial cavity: Disappeared "tumor-like" masses in tuberculous pericarditis. 62
36173749 2022
22
Adjunctive corticosteroid therapy in patients with pulmonary tuberculosis. 62
36228251 2022
23
A 15-year-old girl with pericardial tuberculosis complicated by cardiac tamponade: A case report in Somalia. 62
36045809 2022
24
T cell responses to Mycobacterium indicus pranii immunotherapy and adjunctive glucocorticoid therapy in tuberculous pericarditis. 62
35755143 2022
25
Head-to-head comparison of the diagnostic value of five tests for constrictive tuberculous pericarditis: Five tests for constrictive TBP. 62
35429643 2022
26
Pericarditis caused by Mycobacterium africanum: case report. 62
35850703 2022
27
Primary malignant pericardial mesothelioma with a survival of 2.5 years: a case report. 62
35706788 2022
28
Tuberculous Pericarditis-Own Experiences and Recent Recommendations. 62
35328173 2022
29
Diffuse Linear Pattern of Pericardial FDG Activity in Pericardial Metastasis From Squamous Cell Lung Carcinoma. 62
34284477 2022
30
Tuberculous pericarditis-a silent and challenging disease: A case report. 62
35317150 2022
31
A case report and review of literature: Tuberculous pericarditis with pericardial effusion as the only clinical manifestation. 62
36407454 2022
32
Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis. 62
36439130 2022
33
Comparison of the Diagnostic Accuracy of Xpert MTB/RIF and CapitalBio Mycobacterium RT-PCR Detection Assay for Tuberculous Pericarditis. 62
35498628 2022
34
Tuberculous Pericarditis. 62
35191828 2021
35
Inheritance vs. infectivity as a mechanism of malady and death of Frederic Chopin. 62
34347238 2021
36
Subacute Polymicrobial Bacterial Pericarditis Mimicking Tuberculous Pericarditis: A Case Report. 62
34782592 2021
37
The optimal duration of anti-tuberculous therapy before pericardiectomy in constrictive tuberculous pericarditis. 62
34702309 2021
38
Pericardiectomy for Constrictive Tuberculous Pericarditis: A Systematic Review and Meta-analysis on the Etiology, Patients' Characteristics, and the Outcomes. 62
34722042 2021
39
A case report of tuberculous constrictive pericarditis necessitating total pericardiectomy. 62
34738067 2021
40
Heart failure as a first sign of disseminated tuberculosis. 62
34211669 2021
41
A Case of Crohn's Disease with Cardiac Tamponade Caused by Tuberculous Pericarditis: Assessment of a Rare Phenomenon. 62
34207677 2021
42
Meta-Analysis of Population Characteristics and Outcomes of Patients Undergoing Pericardiectomy for Constrictive Pericarditis. 62
33539860 2021
43
Unusual cause for loss of left ventricular capture in patient with cardiac resynchronization due to tuberculous pericarditis. 62
33586262 2021
44
Neglected cardiovascular diseases and their significance in the Global North. 62
33506326 2021
45
[Tuberculous pericarditis an infrequent extrapulmonary manifestation of TB]. 62
34479275 2021
46
Effusive-Constrictive Pericarditis due to Immune Reconstitution Inflammatory Syndrome following Tuberculous Pericarditis. 62
33644517 2021
47
[Steroids in infection medicine]. 62
33513649 2021
48
Pericardial Masses: A Rare Presentation of Tuberculous Pericarditis Documented by 3D Echocardiography. 62
33566996 2021
49
Corrigendum to "Correlation study between ADA and IFN-γ gene polymorphisms and the risk of developing tuberculous pericarditis" [Gene 676 (2018) 214-218/https://doi.org/10.1016/j.gene.2018.07.032]. 62
33183907 2021
50
An unusual case of tuberculous pericarditis diagnosed exclusively by positive acid-fast staining. 62
33950123 2021

Variations for Pericardial Tuberculosis

Expression for Pericardial Tuberculosis

Search GEO for disease gene expression data for Pericardial Tuberculosis.

Pathways for Pericardial Tuberculosis

GO Terms for Pericardial Tuberculosis

Biological processes related to Pericardial Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.85 TNF CD4 ADA
2 embryonic digestive tract development GO:0048566 9.76 TNF ADA
3 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 TNF IFNG
4 astrocyte activation GO:0048143 9.71 TNF IFNG
5 negative regulation of amyloid-beta clearance GO:1900222 9.62 TNF IFNG
6 negative regulation of lipid storage GO:0010888 9.56 TNF CRP
7 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 TNF IFNG
8 positive regulation of nitrogen compound metabolic process GO:0051173 9.26 TNF IFNG
9 positive regulation of vitamin D biosynthetic process GO:0060557 8.92 TNF IFNG

Sources for Pericardial Tuberculosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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