MCID: PRC005
MIFTS: 38

Pericardial Tuberculosis

Categories: Cardiovascular diseases, Infectious diseases

Aliases & Classifications for Pericardial Tuberculosis

MalaCards integrated aliases for Pericardial Tuberculosis:

Name: Pericardial Tuberculosis 12 15
Pericarditis, Tuberculous 44 73
Tuberculous Pericarditis 12
Pericarditis Tuberculous 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4962
ICD10 33 A18.84
MeSH 44 D010495
SNOMED-CT 68 67256000
UMLS 73 C0031049

Summaries for Pericardial Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that is located in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

MalaCards based summary : Pericardial Tuberculosis, also known as pericarditis, tuberculous, is related to miliary tuberculosis and pericardium cancer. An important gene associated with Pericardial Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Methylprednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and lung, and related phenotypes are immune system and mortality/aging

Related Diseases for Pericardial Tuberculosis

Diseases related to Pericardial Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 miliary tuberculosis 30.1 ADA IFNG
2 pericardium cancer 29.9 PTGER4 SMUG1
3 mycobacterium tuberculosis 1 29.8 ADA IFNG IL10
4 pericarditis 10.8
5 abdominal tuberculosis 10.3 ADA TBP
6 cephalosporin allergy 10.2 IFNG IL10
7 cardiac sarcoidosis 10.2 IFNG SMUG1
8 sporotrichosis 10.2 IFNG IL10
9 nickel allergic contact dermatitis 10.2 IFNG IL10
10 baylisascariasis 10.2 IFNG IL10
11 penicillin allergy 10.2 IFNG IL10
12 hemopericardium 10.2
13 cardiac tamponade 10.2
14 pericardial effusion 10.2
15 central nervous system vasculitis 10.2 IFNG SMUG1
16 chronic graft versus host disease 10.2 IFNG IL10
17 berylliosis 10.2 IFNG POMC
18 clonorchiasis 10.2 IFNG IL10
19 tuberculoid leprosy 10.2 IFNG IL10
20 fungal meningitis 10.2 IFNG IL10
21 mucinoses 10.2 IFNG POMC
22 chronic active epstein-barr virus infection 10.2 IFNG IL10
23 cryptococcal meningitis 10.2 ADA IFNG
24 peanut allergy 10.2 IFNG IL10
25 pleural tuberculosis 10.2 ADA IFNG TBP
26 fascioliasis 10.2 IFNG IL10
27 secondary hypertrophic osteoarthropathy 10.2 POMC SMUG1
28 testicular leydig cell tumor 10.2 POMC SMUG1
29 intermediate uveitis 10.2 IFNG IL10
30 central nervous system hematologic cancer 10.2 IL10 SMUG1
31 epididymis cancer 10.2 CEACAM5 PTGER4
32 epididymis adenocarcinoma 10.2 CEACAM5 PTGER4
33 orofacial granulomatosis 10.2 IFNG IL10
34 adult lymphoma 10.2 CABIN1 SMUG1
35 gastrointestinal tuberculosis 10.2 ADA SMUG1 TBP
36 primary systemic mycosis 10.2 IFNG IL10
37 laryngeal tuberculosis 10.2 POMC SMUG1
38 hand, foot and mouth disease 10.2 IFNG IL10
39 liver lymphoma 10.2 CEACAM5 SMUG1
40 splenic tuberculosis 10.2 CEACAM5 SMUG1
41 mycoplasma pneumoniae pneumonia 10.2 IFNG IL10
42 lymphohistiocytoid mesothelioma 10.2 CEACAM5 PTGER4
43 gallbladder squamous cell carcinoma 10.2 CEACAM5 SMUG1
44 malignant acrospiroma 10.2 CEACAM5 SMUG1
45 poliomyelitis 10.2 IFNG IL10
46 malignant spiradenoma 10.2 CEACAM5 SMUG1
47 nodular hidradenoma 10.2 CEACAM5 PTGER4
48 eales disease 10.2 IFNG IL10
49 thymus adenocarcinoma 10.2 CEACAM5 PTGER4
50 hemorrhagic fever 10.1 IFNG IL10

Graphical network of the top 20 diseases related to Pericardial Tuberculosis:



Diseases related to Pericardial Tuberculosis

Symptoms & Phenotypes for Pericardial Tuberculosis

MGI Mouse Phenotypes related to Pericardial Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.76 ADA CABIN1 IFNG IL10 POMC PRTN3
2 mortality/aging MP:0010768 9.61 ADA CABIN1 IFNG IL10 POMC PTGER4
3 neoplasm MP:0002006 9.02 IFNG IL10 POMC PTGER4 SMUG1

Drugs & Therapeutics for Pericardial Tuberculosis

Drugs for Pericardial Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
2
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
6 Antineoplastic Agents, Hormonal Phase 3
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
8 Peripheral Nervous System Agents Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Hormone Antagonists Phase 3
11 Vaccines Phase 3
12 Prednisolone acetate Phase 3
13 Methylprednisolone acetate Phase 3
14 Hormones Phase 3
15 Antiemetics Phase 3
16 Autonomic Agents Phase 3
17 Gastrointestinal Agents Phase 3
18 Neuroprotective Agents Phase 3
19 Protective Agents Phase 3
20 glucocorticoids Phase 3
21 Fibrinolytic Agents Phase 3
22 Tissue Plasminogen Activator Phase 3
23 Plasminogen Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis Completed NCT00810849 Phase 3 Prednisolone
2 IMPI 2 - A Trial of Intrapericardial Alteplase in Large Pericardial Effusion Recruiting NCT02673879 Phase 3

Search NIH Clinical Center for Pericardial Tuberculosis

Cochrane evidence based reviews: pericarditis, tuberculous

Genetic Tests for Pericardial Tuberculosis

Anatomical Context for Pericardial Tuberculosis

MalaCards organs/tissues related to Pericardial Tuberculosis:

41
Liver, Bone, Lung, Colon, Thyroid, Testis, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Pericardial Tuberculosis:

19
Pericardium

Publications for Pericardial Tuberculosis

Articles related to Pericardial Tuberculosis:

(show all 15)
# Title Authors Year
1
Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study. ( 29750184 )
2018
2
Suspected Pericardial Tuberculosis Revealed as an Amyloid Pericardial Mass. ( 30416832 )
2018
3
A primary intestinal lymphangiectasia hiding the diagnosis of pleural and pericardial tuberculosis: a clinical observation. ( 28491220 )
2017
4
Diffuse pseudo-tumoral pericardial tuberculosis. ( 28065910 )
2017
5
Immune thrombocytopenia associated with pleural and pericardial tuberculosis: case report. ( 27208577 )
2016
6
Pericardial tuberculosis with an emphasis on empiric therapy in endemic areas for tuberculosis (a case report). ( 27847027 )
2016
7
Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis. ( 26870790 )
2015
8
A Compartmentalized Profibrotic Immune Response Characterizes Pericardial Tuberculosis, Irrespective of HIV-1 Infection. ( 26669475 )
2015
9
Comprehensive cardiovascular magnetic resonance for monitoring the response to therapy in pericardial tuberculosis. ( 24286735 )
2013
10
Pericardial tuberculosis. ( 23843490 )
2013
11
Persistent pyrexia post-liver transplantation: a unique case of pericardial tuberculosis. ( 19046713 )
2008
12
Detection of Mycobacterium tuberculosis complex DNA in pericardial fluid, bone marrow and peripheral blood in a patient with pericardial tuberculosis. A case report. ( 11578792 )
2001
13
Serodiagnosis of pericardial tuberculosis. ( 7796085 )
1995
14
Utility of scalene node biopsy in the diagnosis of pleuro-pericardial tuberculosis. ( 4448816 )
1974
15
Pleural, peritoneal, and pericardial tuberculosis; a review of 209 cases uncomplicated by treatment or secondary infection. ( 15413770 )
1950

Variations for Pericardial Tuberculosis

Expression for Pericardial Tuberculosis

Search GEO for disease gene expression data for Pericardial Tuberculosis.

Pathways for Pericardial Tuberculosis

Pathways related to Pericardial Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.54 CABIN1 CEACAM5 IFNG IL10 TRIM25
2 11.4 CEACAM5 IFNG IL10
3 11.05 IFNG POMC TBP
4 10.78 IFNG IL10
5 10.67 IFNG IL10

GO Terms for Pericardial Tuberculosis

Biological processes related to Pericardial Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytokine secretion GO:0050715 8.96 IL10 PTGER4
2 negative regulation of inflammatory response GO:0050728 8.8 ADA IL10 PTGER4

Sources for Pericardial Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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