Aliases & Classifications for Pericarditis

MalaCards integrated aliases for Pericarditis:

Name: Pericarditis 12 54 44 15 62 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1787
MeSH 44 D010493
NCIt 50 C34915
SNOMED-CT 67 3238004
ICD10 32 I32 I32.8
UMLS 70 C0031046

Summaries for Pericarditis

PubMed Health : 62 About pericarditis: Pericarditis (PER-ih-kar-DI-tis) is a condition in which the membrane, or sac, around your heart is inflamed. This sac is called the pericardium (per-ih-KAR-de-um). The pericardium holds the heart in place and helps it work properly. The sac is made of two thin layers of tissue that enclose your heart. Between the two layers is a small amount of fluid. This fluid keeps the layers from rubbing against each other and causing friction.

MalaCards based summary : Pericarditis is related to constrictive pericarditis and pericardial tuberculosis, and has symptoms including chest pain An important gene associated with Pericarditis is PRG4 (Proteoglycan 4), and among its related pathways/superpathways are Innate Immune System and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Coal tar and Colchicine have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and breast, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A pericardium disease that is characterized by an inflammation of the pericardium and has symptom chest pain.

Wikipedia : 73 Pericarditis is inflammation of the pericardium (the fibrous sac surrounding the heart). Symptoms... more...

Related Diseases for Pericarditis

Diseases related to Pericarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1208)
# Related Disease Score Top Affiliating Genes
1 constrictive pericarditis 32.9 NPPB IFNG CRP ADA
2 pericardial tuberculosis 32.7 IFNG CRP ADA
3 idiopathic recurrent pericarditis 32.0 TNFRSF1A MEFV LEP ADIPOQ
4 drug reaction with eosinophilia and systemic symptoms 32.0 TNF CRP
5 systemic onset juvenile idiopathic arthritis 31.9 TNF MEFV IL6
6 cardiac tamponade 31.9 TNFRSF1A NPPB CRP ADA
7 pericardial effusion 31.9 TNFRSF1A NPPB IL6 CRP ADA
8 juvenile rheumatoid arthritis 31.3 TNFRSF1A TNF IL6 IL1B IFNG CXCL8
9 pleural empyema 31.2 IL6 CRP ADA
10 myocarditis 31.2 TNF NPPB IL6 IL1B IFNG
11 haemophilus influenzae 31.1 TNF CXCL8
12 systemic lupus erythematosus 31.0 TNFRSF1A TNF IL6 IL1B IFNG CXCL8
13 endocarditis 31.0 TNF IL6 IFNG CXCL8 CRP
14 vasculitis 31.0 TNF MEFV IL6 CRP
15 infective endocarditis 30.9 TNNT2 TNF IL6 CRP
16 acute myocardial infarction 30.8 TNNT2 NPPB IL6 CRP
17 enthesopathy 30.8 TNF MEFV CRP
18 mitral valve insufficiency 30.8 TNNT2 NPPB CRP
19 uremia 30.8 TNF LEP IL6 CRP
20 cardiogenic shock 30.7 TNF NPPB IL6
21 pleurisy 30.7 TNF MEFV IFNG CXCL8 CRP ADA
22 acute myocarditis 30.6 TNNT2 TNF NPPB CRP
23 sarcoidosis 1 30.6 TNF IL1B IFNG CRP ADA
24 chickenpox 30.6 TNF IL6 IFNG CRP ADA
25 mycobacterium tuberculosis 1 30.5 TNF P2RX7 IFNG ADA
26 pneumonia 30.5 TNF IL6 IL1B IFNG CXCL8 CRP
27 pulmonary tuberculosis 30.5 TNF P2RX7 IL6 IFNG ADA
28 nocardiosis 30.5 TNF IFNG CRP
29 brucellosis 30.5 TNF MEFV IL6 IFNG CXCL8 CRP
30 rheumatic fever 30.5 TNF NPPB IL6 IFNG
31 q fever 30.5 TNF P2RX7 IL6 IL1B IFNG
32 arthropathy 30.5 TPR TNF PRG4 IL6 IL1B IFNG
33 familial mediterranean fever 30.4 TNFRSF1A TNF MEFV IL6 IL1B CXCL8
34 angina pectoris 30.4 NPPB IL6 CRP ADIPOQ
35 actinomycosis 30.4 TNF IL6 IL1B CRP
36 colitis 30.4 TNF IL6 IL1B IFNG CXCL8
37 cardiac rupture 30.4 TNF CXCL8 CRP
38 rheumatic heart disease 30.4 TNF NPPB IL6 IL1B
39 echinococcosis 30.4 TNF IL6 IFNG
40 ulcerative colitis 30.4 TNF IL6 IL1B IFNG CXCL8 CRP
41 miliary tuberculosis 30.4 TNF IFNG CRP ADA
42 melioidosis 30.4 TNF IL6 IFNG
43 pulmonary embolism 30.4 TNNT2 NPPB CRP
44 toxic shock syndrome 30.4 TNF IL6 IL1B IFNG CXCL8 CRP
45 varicose veins 30.4 TNF IL6 CXCL8
46 connective tissue disease 30.4 TNF IL6 IL1B IFNG CXCL8 CRP
47 cellulitis 30.4 TNF IL6 CRP
48 polyarteritis nodosa 30.4 MEFV IL6 CRP
49 meningitis 30.4 TNF IRAK4 IL6 IL1B IFNG CXCL8
50 congestive heart failure 30.4 TNNT2 TNF NPPB IL6 IL1B CRP

Graphical network of the top 20 diseases related to Pericarditis:



Diseases related to Pericarditis

Symptoms & Phenotypes for Pericarditis

Symptoms:

12
  • chest pain

MGI Mouse Phenotypes related to Pericarditis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.29 ADA ADIPOQ IFNG IL1B IL6 LEP
2 homeostasis/metabolism MP:0005376 10.28 ADA ADIPOQ CRP IFNG IL1B IL6
3 cardiovascular system MP:0005385 10.27 ADA ADIPOQ CRP IFNG IL1B IL6
4 hematopoietic system MP:0005397 10.23 ADA ADIPOQ IFNG IL1B IL6 IRAK4
5 immune system MP:0005387 10.22 ADA ADIPOQ CRP IFNG IL1B IL6
6 integument MP:0010771 10.07 ADIPOQ IFNG IL1B IL6 LEP MEFV
7 liver/biliary system MP:0005370 9.92 ADA ADIPOQ IFNG IL6 LEP MEFV
8 muscle MP:0005369 9.86 ADA ADIPOQ IFNG IL6 LEP TNF
9 neoplasm MP:0002006 9.7 ADIPOQ IFNG IL1B IL6 LEP TNF
10 respiratory system MP:0005388 9.56 ADA ADIPOQ IFNG IL6 LEP TNF
11 skeleton MP:0005390 9.32 ADA ADIPOQ IFNG IL1B IL6 LEP

Drugs & Therapeutics for Pericarditis

PubMed Health treatment related to Pericarditis: 62

Most cases of pericarditis are mild; they clear up on their own or with rest and simple treatment . Other times, more intense treatment is needed to prevent complications. Treatment may include medicines and, less often, procedures or surgery . The goals of treatment include: Reducing pain and inflammation Treating the underlying cause, if it's known Checking for complications

Drugs for Pericarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Coal tar Approved Phase 4 8007-45-2
2
Colchicine Approved Phase 4 64-86-8 6167 2833
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Ibuprofen Approved Phase 4 15687-27-1 3672
7
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
8 Interleukin 1 Receptor Antagonist Protein Phase 4
9 Hormone Antagonists Phase 4
10 glucocorticoids Phase 4
11 Hormones Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Gastrointestinal Agents Phase 4
14 Antiemetics Phase 4
15 Antirheumatic Agents Phase 4
16 Anti-Inflammatory Agents Phase 4
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18 Analgesics, Non-Narcotic Phase 4
19 Fibrinolytic Agents Phase 4
20 Analgesics Phase 4
21 Cyclooxygenase Inhibitors Phase 4
22 Platelet Aggregation Inhibitors Phase 4
23 Antipyretics Phase 4
24
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
25
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
26
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
27
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
28
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
29
Rilonacept Approved, Investigational Phase 3 501081-76-1 104924
30
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
31 Plasminogen Phase 3
32 Tissue Plasminogen Activator Phase 3
33 Methylprednisolone Acetate Phase 3
34 Vaccines Phase 3
35 Pharmaceutical Solutions Phase 2, Phase 3
36 Tubulin Modulators Phase 2, Phase 3
37 Antimitotic Agents Phase 2, Phase 3
38
Ethanol Approved Phase 2 64-17-5 702
39
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
40
Rifampicin Approved Phase 2 13292-46-1 5381226 5458213
41 Narcotics Phase 2
42 Analgesics, Opioid Phase 2
43 Narcotic Antagonists Phase 2
44 Antibiotics, Antitubercular Phase 2
45 Antitubercular Agents Phase 2
46 Anti-Infective Agents Phase 2
47 Anti-Bacterial Agents Phase 2
48
Atezolizumab Approved, Investigational 1380723-44-3
49
Ipilimumab Approved 477202-00-9
50
Pembrolizumab Approved 1374853-91-4

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 AnakInRa for Treatment of Recurrent Idiopathic Pericarditis Completed NCT02219828 Phase 4 Anakinra;Placebo
2 Treatment and Prevention of Pericarditis With Colchicine. A Multicenter Double Blind Randomized Trial. The CORP 2 Trial: COlchicine for Recurrent Pericarditis. Completed NCT00235079 Phase 4 Colchicine;Placebo
3 Dexamethasone Compared to Non-steroidal Anti-inflammatory Drugs in the Treatment of Acute Pericarditis: a Non-inferiority Randomized Controlled Trial (Dexa-P) Recruiting NCT04323280 Phase 4 Dexamethasone therapy;NSAID therapy
4 Benign Acute Pericarditis: Brief Versus Longer Treatment. Randomized, Multicentric, Double Blind, Non Inferiority Trial Terminated NCT00946907 Phase 4 Aspirin;placebo
5 A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis Unknown status NCT02673879 Phase 3
6 Treatment and Prevention of Pericarditis With Colchicine. A Multicenter Double Blind Randomized Trial. The ICAP Trial: Investigation on Colchicine for Acute Pericarditis Completed NCT00128453 Phase 3 Colchicine (for 3 months);Placebo
7 Treatment and Prevention of Pericarditis With Colchicine. A Multicenter Double Blind Randomized Trial. The CORP Trial: COlchicine for Recurrent Pericarditis Completed NCT00128414 Phase 3 Colchicine (for 6 months);Placebo
8 A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis Completed NCT00810849 Phase 3 Prednisolone
9 Treatment and Prevention of Pericarditis With Colchicine. A Multicenter Double Blind Randomized Trial. The COPPS Trial: COlchicine for the Prevention of Postpericardiotomy Syndrome Completed NCT00128427 Phase 3 Colchicine (for 1 month)
10 A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Efficacy and Safety of RPH-104 Treatment in Patients With Idiopathic Recurrent Pericarditis Recruiting NCT04692766 Phase 2, Phase 3 Placebo
11 Phase 3, Double-Blind, Placebo-Controlled, Randomized Withdrawal Study With Open-label Extension, to Assess the Efficacy and Safety of Rilonacept Treatment in Subjects With Recurrent Pericarditis Active, not recruiting NCT03737110 Phase 3 Rilonacept;Placebo
12 Colchicine in Postoperative Fontan Patients (CPFP) Terminated NCT03575572 Phase 2, Phase 3 Colchicine
13 An Open-Label Pilot Study of KPL-914 in Recurrent Pericarditis Completed NCT03980522 Phase 2 KPL-914
14 Randomized Trial to Evaluate the Safety and Efficacy of a New Surgical Approach to Cardiac Regeneration: Pericardic Adipose Pedicle Transposition Over the Myocardial Infarct (adiFLAP Trial) Completed NCT01473433 Phase 1, Phase 2
15 Impact of Colchicine and Low-dose Naltrexone on COVID-19 Disease Progression and Clinical Course in Hospitalized Patients Enrolling by invitation NCT04756128 Phase 2 Colchicine 0.6 mg;Naltrexone
16 IMPI-3 - A Randomized Controlled Trial of High vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis Not yet recruiting NCT04521803 Phase 2 high dose Rifampicin (RIF)
17 Treatment of Acute Pericarditis With Anakinra Terminated NCT03224585 Phase 2 Anakinra;Placebo
18 Septal Shift for the Diagnosis of COnstrictive Pericarditis: The Impact of Inspiratory Effort Quantification on Deep Breathing Manoeuvres (SCOPED) Unknown status NCT02685371
19 Improvement of the Etiological Diagnosis of the Pericarditis Unknown status NCT02828085
20 Noise of Airplanes a Factor of Risk for the Health of the Heart in Pilots and Crew in Operations of the F16 Airplane Unknown status NCT01063582
21 Clinical Audit of the Management of Pericarditis in Children. Unknown status NCT03253315
22 A Survey of Hospitalizations in Cardiology Units in Sub-Saharan Africa Unknown status NCT03231449
23 Characterization of the Liver Parenchyma Using Parametric T1 and T2 Magnetic Resonance Relaxometry Completed NCT04623528
24 ST Elevation (Acute Coronary Syndrome Versus Pericarditis;Could Measurement of Lp-associated PLA2 -a Vascular Specific Marker of Inflammation- be Helpful to the Clinician? Completed NCT01041339
25 ACAM2000® Myopericarditis Registry Completed NCT01395082
26 A Translational Study to Understand the Mechanism of Apolipoprotein CIII Reduction Via Colchicine Completed NCT02083510 Early Phase 1 Colchicine
27 Prognostic Biomarkers in Patients With Acute Pericarditis Recruiting NCT02754713
28 JOint Use of Database to Identify Risk Factors of CARDio-vascular Adverse Reactions Induced by Immune Checkpoint InhibiTors: VigiBase, Entrepot de Données de Santé (EDS), Système National Des Données de Santé (SNDS) Databases and a Retrospective International Multicenter Registry of ICI-associated Myocarditis Active, not recruiting NCT04294771 ICI
29 Inflammatory Cardiomyopathy Bern Registry Enrolling by invitation NCT04774549
30 Patterns of Arrhythmias and Conduction Block in COVID-19 Patients and Its Relation to Myocardial Injury Detected by Cardiac Magnetic Resonance Not yet recruiting NCT04584411
31 Registry of the Natural History of Recurrent Pericarditis in Pediatric and Adult Patients Not yet recruiting NCT04687358
32 Constrictive Pericarditis in the Adult Congenital Cardiac Population Terminated NCT00268086
33 Pressure-Volume Analysis of Constrictive Pericarditis Withdrawn NCT02027350

Search NIH Clinical Center for Pericarditis

Cochrane evidence based reviews: pericarditis

Genetic Tests for Pericarditis

Anatomical Context for Pericarditis

MalaCards organs/tissues related to Pericarditis:

40
Heart, Liver, Breast, Bone, Kidney, Bone Marrow, Brain

Publications for Pericarditis

Articles related to Pericarditis:

(show top 50) (show all 11910)
# Title Authors PMID Year
1
Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. 61 54
20074469 2009
2
Tuberculous pericarditis. 54 61
16330703 2005
3
Adenosine deaminase activity--more than a diagnostic tool in tuberculous pericarditis. 61 54
16049586 2005
4
Idiopathic recurrent acute pericarditis: familial Mediterranean fever mutations and disease evolution in a large cohort of Caucasian patients. 61 54
16218464 2005
5
The role of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) evaluation in pericardial fluid for the recognition of malignant pericarditis. 54 61
9479590 1997
6
Genetic disorders with symptoms mimicking rheumatologic diseases: A single-center retrospective study. 61
33662637 2021
7
A novel model of constrictive pericarditis associated with myocardial fibrosis in rats. 61
33349990 2021
8
Egg-shell calcification in Pick's disease (chronic constrictive pericarditis). 61
33552337 2021
9
A Rare Case of Pyopericardium After Blunt Thoracic Trauma. 61
32882194 2021
10
Constrictive Pericarditis after Open Heart Surgery: A 20-Year Case Controlled Study. 61
33421450 2021
11
Outcomes of Tricuspid Valve Operation at the Time of Pericardiectomy for Constrictive Pericarditis. 61
32896543 2021
12
Clinical features and prognosis of surgically proven constrictive pericarditis after orthotopic heart transplantation. 61
33546972 2021
13
Commercial Air Travel for Passengers With Cardiovascular Disease: Recommendations for Less Common Conditions, Considerations for Venous Thromboembolism, and General Guidance. 61
33412348 2021
14
Identification of risk genes related to myocardial infarction and the construction of early SVM diagnostic model. 61
33352151 2021
15
Pericarditis and Pericardial Effusion in a Patient with Tophaceous Gout. Infection or Complication Due to Deposit of Microcrystals? 61
31523032 2021
16
Acute Pericarditis: Aetiologic Diagnosis and Practical Aspect of the Management. 61
33412346 2021
17
A rare case of primary angiosarcoma of the anterior mediastinum. 61
33222090 2021
18
Pericarditis as a cardiac manifestation of acute leptospirosis. 61
32779123 2021
19
Pericardial Involvement in Cancer. 61
33460602 2021
20
Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases. 61
33482337 2021
21
A Fatal Case of Cardiac Contusion After Blunt Chest Injury. 61
32732593 2021
22
Calcified constrictive pericarditis resulting in tamponade in a patient with systemic lupus erythematosus. 61
33206224 2021
23
Hemodialysis Emergencies: Core Curriculum 2021. 61
33771393 2021
24
Cardiotoxicities of novel cancer immunotherapies. 61
33722826 2021
25
Colchicine efficacy and safety for the treatment of cardiovascular diseases. 61
33704674 2021
26
Cardiovascular disorders in hospitalized patients with dengue infection. 61
32345488 2021
27
Case of a 21-year-old man with persistent lung collapse leading to a pericardectomy linked to vape use. 61
33373941 2021
28
Anterior mediastinal ectopic pancreatic cyst incidentally identified by pericarditis: a case report. 61
33136258 2021
29
Streptococcus pneumoniae purulent pericarditis secondary to influenza A infection and pneumococcal pneumonia in an immunocompetent woman. 61
33692069 2021
30
Recognizing Cutibacterium acnes as a cause of infectious pericarditis: A case report and review of literature. 61
33771686 2021
31
Management of acute and recurrent pericarditis in pregnancy. 61
33687181 2021
32
Anti-interleukin 1 agents for the treatment of recurrent pericarditis: a systematic review and meta-analysis. 61
33737453 2021
33
Transient Manifestation of J Waves and Brugada Pattern Electrocardiograms in Patients With Acute Pericarditis. 61
33736760 2021
34
Acute Idiopathic Pericarditis: Is it Actually Always Idiopathic? 61
33736835 2021
35
Reply: Acute Idiopathic Pericarditis: Is it Actually Always Idiopathic? 61
33736836 2021
36
A case of acute bacterial pericarditis in a COVID-19 patient. 61
33721972 2021
37
The tale of refractory recurrent pericarditis. 61
33735418 2021
38
Delayed-onset constrictive pericarditis associated with trauma. 61
33727294 2021
39
MELD and MELD XI Scores as Predictors of Mortality After Pericardiectomy for Constrictive Pericarditis. 61
33673914 2021
40
Dilated right ventricular outflow tract in a young woman due to localized constrictive pericarditis: cardiac CT and MRI findings. 61
33408800 2021
41
Ventricular Systolic Discordance Post-Premature Ventricular Complex in Constrictive Pericarditis: A Novel Description. 61
33663233 2021
42
Prevalence of Inflammatory Heart Disease Among Professional Athletes With Prior COVID-19 Infection Who Received Systematic Return-to-Play Cardiac Screening. 61
33662103 2021
43
Needle in the heart: a rare case of cardiac tamponade caused by a migrated foreign body and mimicking ST segment elevation myocardial infarction. 61
33730997 2021
44
Cardiac involvement in eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): Prospective evaluation at a tertiary referral centre. 61
33358337 2021
45
Pleuritis and Pericarditis in ANCA-Associated Vasculitis. 61
33667492 2021
46
Malaria and the Heart: JACC State-of-the-Art Review. 61
33632486 2021
47
Tuberculosis and the Heart. 61
33733808 2021
48
Coronary artery spasm in a 15-year-old male in diabetic ketoacidosis. 61
33719987 2021
49
Neglected cardiovascular diseases and their significance in the Global North. 61
33506326 2021
50
Ten Years of National Seasonal Surveillance for Severe Complications of Influenza in Australian Children. 61
33093432 2021

Variations for Pericarditis

Expression for Pericarditis

Search GEO for disease gene expression data for Pericarditis.

Pathways for Pericarditis

Pathways related to Pericarditis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 TPR TNFRSF1A TNF P2RX7 MEFV IRAK4
2
Show member pathways
13.43 TNFRSF1A TNF NPPB LEP IL6 IL1B
3
Show member pathways
13.39 TPR TNFRSF1A TNF IRAK4 IL6 IL1B
4
Show member pathways
13.24 TNFRSF1A TNF IRAK4 IL6 IL1B IFNG
5
Show member pathways
12.98 TNFRSF1A TNF IRAK4 IL6 IL1B CXCL8
6
Show member pathways
12.88 TNF IL6 IL1B IFNG CXCL8
7
Show member pathways
12.85 TNFRSF1A TNF IRAK4 IL6 IL1B IFNG
8 12.84 TNFRSF1A TNF IRAK4 IL6 IL1B IFNG
9
Show member pathways
12.81 TNFRSF1A TNF LEP IL6 ADIPOQ
10
Show member pathways
12.78 TNFRSF1A TNF IRAK4 IL6 IL1B CXCL8
11
Show member pathways
12.76 TNF P2RX7 IRAK4 IL6 IL1B CXCL8
12
Show member pathways
12.74 TNFRSF1A TNF IRAK4 IL6 IL1B
13
Show member pathways
12.7 TRAF3IP2 TNFRSF1A TNF IL1B IFNG
14 12.61 TNFRSF1A TNF IRAK4 IL1B IFNG
15 12.43 TNFRSF1A TNF IL1B CXCL8
16
Show member pathways
12.37 TNF IL6 IL1B IFNG CRP
17
Show member pathways
12.36 TNFRSF1A TNF IL6 CXCL8
18
Show member pathways
12.36 TNF IRAK4 IL6 IL1B IFNG CXCL8
19
Show member pathways
12.36 TRAF3IP2 TNF IL6 IL1B IFNG CXCL8
21
Show member pathways
12.31 TNF IL6 IL1B IFNG CXCL8
22
Show member pathways
12.3 TNF IRAK4 IL6 CXCL8
23
Show member pathways
12.3 TNFRSF1A TNF IRAK4 IL1B IFNG
24
Show member pathways
12.25 TNFRSF1A TNF IL1B IFNG
25 12.23 TNFRSF1A TNF IL6 IFNG
26 12.23 TNFRSF1A TNF IRAK4 IL6 IL1B IFNG
27 12.22 TNF IL6 IL1B CXCL8
28 12.14 TNFRSF1A TNF IL1B IFNG
29
Show member pathways
12.13 TNF IRAK4 IL6 IL1B IFNG CXCL8
30 12.11 TNF LEP IL6 ADIPOQ
31 12.09 TNFRSF1A TNF IL1B IFNG
32 12.03 TNF IL6 IL1B CXCL8
33 12.02 TNFRSF1A TNF IL6 IL1B
34 11.99 IL6 IL1B IFNG CXCL8
35 11.98 TNFRSF1A TNF IRAK4 IL1B CXCL8
36 11.98 TNF MEFV IRAK4 IL6 IL1B CXCL8
37 11.96 TNF IL6 IL1B CXCL8
38 11.96 TNF IL6 IL1B IFNG CXCL8
39 11.93 TNNT2 LEP IL6 ADIPOQ
40 11.89 TNF IL6 IL1B IFNG CXCL8
41 11.83 IL6 IFNG CXCL8
42
Show member pathways
11.82 TNF IL6 IL1B IFNG
43 11.81 TNF IL1B IFNG
44 11.8 TNF IL6 IL1B IFNG
45
Show member pathways
11.79 TNF IFNG CXCL8
46 11.76 TNFRSF1A TNF LEP ADIPOQ
47 11.76 TNF IRAK4 IL6 IL1B CXCL8
48 11.76 TNF P2RX7 MEFV IRAK4 IL6 IL1B
49 11.72 TNF IL6 IL1B CXCL8
50 11.71 TNF LEP IL6 IL1B IFNG CXCL8

GO Terms for Pericarditis

Cellular components related to Pericarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNFRSF1A TNF PSG2 PRG4 NPPB LEP
2 extracellular space GO:0005615 9.4 TNFRSF1A TNF NPPB LEP IRAK4 IL6

Biological processes related to Pericarditis according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.09 TNF PRG4 IL6 IL1B IFNG CXCL8
2 positive regulation of gene expression GO:0010628 9.98 TNF P2RX7 IL6 IL1B IFNG CXCL8
3 positive regulation of protein phosphorylation GO:0001934 9.97 TNF LEP IL1B IFNG ADIPOQ
4 cellular response to lipopolysaccharide GO:0071222 9.96 TNF IL6 IL1B CXCL8
5 negative regulation of inflammatory response GO:0050728 9.93 TNFRSF1A MEFV ADIPOQ ADA
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.93 TRAF3IP2 TNFRSF1A TNF IRAK4 ADIPOQ
7 cytokine-mediated signaling pathway GO:0019221 9.93 TNFRSF1A TNF IRAK4 IL6 IL1B CXCL8
8 positive regulation of inflammatory response GO:0050729 9.89 TNFRSF1A TNF IL1B IFNG
9 positive regulation of interleukin-6 production GO:0032755 9.88 TNF IL6 IL1B IFNG
10 response to glucocorticoid GO:0051384 9.87 TNF IL6 ADIPOQ
11 positive regulation of T cell proliferation GO:0042102 9.86 LEP IL6 IL1B
12 glucose metabolic process GO:0006006 9.86 TNF LEP ADIPOQ
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 TNF IRAK4 IL6
14 positive regulation of cytokine production GO:0001819 9.85 TNF LEP IFNG
15 negative regulation of fat cell differentiation GO:0045599 9.85 TNF IL6 ADIPOQ
16 response to activity GO:0014823 9.84 LEP IL6 ADIPOQ
17 positive regulation of phagocytosis GO:0050766 9.83 TNF IL1B IFNG
18 extrinsic apoptotic signaling pathway GO:0097191 9.83 TNF P2RX7 IFNG
19 positive regulation of interleukin-8 production GO:0032757 9.83 TNF IL6 IL1B ADIPOQ
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 TNF IL1B IFNG
21 positive regulation of protein import into nucleus GO:0042307 9.82 TPR LEP IFNG
22 positive regulation of chemokine production GO:0032722 9.81 TNF IL6 IFNG
23 positive regulation of JAK-STAT cascade GO:0046427 9.8 TNF LEP IL6
24 humoral immune response GO:0006959 9.8 TRAF3IP2 TNF IL6 IFNG
25 positive regulation of interleukin-1 beta production GO:0032731 9.78 TNF P2RX7 IL6 IFNG
26 negative regulation of neurogenesis GO:0050768 9.77 TNF IL6 IL1B
27 positive regulation of glial cell proliferation GO:0060252 9.74 TNF IL6 IL1B
28 embryonic digestive tract development GO:0048566 9.73 TNF CXCL8 ADA
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 TNF IL1B IFNG
30 regulation of insulin secretion GO:0050796 9.72 TNF LEP IL6 IL1B IFNG
31 negative regulation of amyloid-beta clearance GO:1900222 9.7 TNF IFNG
32 negative regulation of synaptic transmission GO:0050805 9.7 IL1B ADIPOQ
33 neutrophil mediated immunity GO:0002446 9.7 IRAK4 IL6
34 response to vitamin E GO:0033197 9.69 LEP ADA
35 death-inducing signaling complex assembly GO:0071550 9.69 TNFRSF1A TNF
36 positive regulation of neuroinflammatory response GO:0150078 9.69 TNF IL6 IL1B
37 germinal center B cell differentiation GO:0002314 9.67 IL6 ADA
38 positive regulation of fever generation GO:0031622 9.66 TNF IL1B
39 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 TNFRSF1A TNF LEP IL6 IFNG
40 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
41 positive regulation of vitamin D biosynthetic process GO:0060557 9.61 TNF IFNG
42 positive regulation of nitrogen compound metabolic process GO:0051173 9.61 TNF IFNG
43 regulation of establishment of endothelial barrier GO:1903140 9.58 TNFRSF1A TNF IL1B
44 inflammatory response GO:0006954 9.56 TRAF3IP2 TNFRSF1A TNF MEFV IL6 IL1B
45 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6 IL1B
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.33 TNF IL1B IFNG
47 negative regulation of lipid storage GO:0010888 8.92 TNF LEP IL6 CRP

Molecular functions related to Pericarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 TRAF3IP2 P2RX7 NPPB LEP ADIPOQ
2 cytokine activity GO:0005125 9.1 TNF IL6 IL1B IFNG CXCL8 ADIPOQ

Sources for Pericarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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