MCID: PRC050
MIFTS: 31

Pericardium Disease

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Pericardium Disease

MalaCards integrated aliases for Pericardium Disease:

Name: Pericardium Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050829
ICD10 32 I31.8 I31.9

Summaries for Pericardium Disease

Disease Ontology : 12 A cardiovascular system disease that is located in the fibrous sac surrounding the heart.

MalaCards based summary : Pericardium Disease is related to pericarditis and pericardial effusion. An important gene associated with Pericardium Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways are Salmonella infection (KEGG) and Immune response IL-23 signaling pathway. Affiliated tissues include fibrous sac surrounding the heart and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 The pericardium, also called pericardial sac, is a double-walled sac containing the heart and the roots... more...

Related Diseases for Pericardium Disease

Diseases in the Pericardium Disease family:

Congenital Pericardium Anomaly

Diseases related to Pericardium Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 867)
# Related Disease Score Top Affiliating Genes
1 pericarditis 30.9 TNNT2 TNNI3 TNF PRG4 NPPB MEFV
2 pericardial effusion 30.7 TNNI3 REN PRTN3 PIK3C2A NPPB IL6
3 acute dacryoadenitis 10.5 CRP ACE
4 orbital osteomyelitis 10.5 F2 CRP
5 chronic duodenal ileus 10.5 CRP ALB
6 non-a-e hepatitis 10.5 F2 ALB
7 mediastinum teratoma 10.5 CRP ACE
8 antipyrine metabolism 10.5 F2 ALB
9 small intestine diverticulitis 10.5 F2 CRP
10 sarcoid meningitis 10.5 PIK3C2A ACE
11 dipetalonemiasis 10.5 GPT ALB
12 anterolateral myocardial infarction 10.5 NPPB ACE
13 spontaneous tension pneumothorax 10.5 NPPB GPT
14 pancreas lymphoma 10.5 GPT ACE
15 pneumoconiosis due to talc 10.5 F2 ACE
16 cork-handlers' disease 10.5 CD4 ALB
17 vibrio vulnificus infection 10.5 PIK3C2A IL6
18 riedel's fibrosing thyroiditis 10.5 CD4 ALB
19 cardiac tuberculosis 10.5 NPPB CRP ACE
20 acute anterolateral myocardial infarction 10.5 PIK3C2A ACE
21 drug reaction with eosinophilia and systemic symptoms 10.5 TNF CRP
22 heterophyiasis 10.5 GPT ALB
23 afferent loop syndrome 10.5 GPT ALB
24 purulent acute otitis media 10.5 PRTN3 CRP
25 external pathological resorption 10.5 TNF IL6
26 interstitial myocarditis 10.5 TNNI3 PIK3C2A
27 hematocele of tunica vaginalis testis 10.5 F2 CRP
28 anteroseptal myocardial infarction 10.5 PIK3C2A ACE
29 cold agglutinin disease 10.5 IL6 CRP
30 uvulitis 10.5 GPT CRP
31 pyeloureteritis cystica 10.5 REN CRP
32 first-degree atrioventricular block 10.5 NPPB CRP ACE
33 scorpion envenomation 10.5 TNF IL6
34 cholecystitis 10.5 GPT F2 ALB
35 congenitally corrected transposition of the great arteries 10.5 TNNT2 NPPB
36 chronic thromboembolic pulmonary hypertension 10.5 NPPB CRP
37 peptic ulcer perforation 10.5 CRP ALB
38 gummatous syphilis 10.5 GPT CRP
39 lateral myocardial infarction 10.5 TNNI3 PIK3C2A ACE
40 achenbach syndrome 10.5 F3 F2 CRP
41 ankylosing spondylitis 3 10.5 CRP ALB
42 secondary hemophagocytic lymphohistiocytosis 10.5 TNF ADA
43 renal pelvis squamous cell carcinoma 10.5 F3 F2 CRP
44 basidiobolomycosis 10.5 PIK3C2A GPT CRP
45 papillary adenofibroma 10.5 F3 F2
46 hepatoportal sclerosis 10.5 GPT F2 ACE
47 synovial angioma 10.5 F3 F2 CRP
48 femoral neuropathy 10.5 F3 F2
49 panophthalmitis 10.5 CRP CD4
50 asphyxia neonatorum 10.5 IL6 CRP ALB

Graphical network of the top 20 diseases related to Pericardium Disease:



Diseases related to Pericardium Disease

Symptoms & Phenotypes for Pericardium Disease

MGI Mouse Phenotypes related to Pericardium Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 ACE ADA ALB CRP F2 F3
2 homeostasis/metabolism MP:0005376 10.1 ACE ADA ALB CD4 CRP F2
3 immune system MP:0005387 10 ACE ADA ALB CD4 CRP F2
4 mortality/aging MP:0010768 9.8 ACE ADA ALB CD4 F2 F3
5 muscle MP:0005369 9.28 ADA ALB F2 F3 IL6 REN

Drugs & Therapeutics for Pericardium Disease

Search Clinical Trials , NIH Clinical Center for Pericardium Disease

Genetic Tests for Pericardium Disease

Anatomical Context for Pericardium Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Pericardium Disease:

19
Fibrous Sac Surrounding The Heart

MalaCards organs/tissues related to Pericardium Disease:

40
Heart

Publications for Pericardium Disease

Articles related to Pericardium Disease:

# Title Authors PMID Year
1
The first post-cardiac injury syndrome reported following transcatheter aortic valve implantation: a case report. 61
31020183 2018

Variations for Pericardium Disease

Expression for Pericardium Disease

Search GEO for disease gene expression data for Pericardium Disease.

Pathways for Pericardium Disease

Pathways related to Pericardium Disease according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 TNF PIK3C2A IL6 IL1B F2
2
Show member pathways
12.48 TNF IL6 IL1B F2 CD4
3 12.14 TNF MEFV IL6 IL1B
4 11.95 TNNT2 TNNI3 IL6 ALB
5
Show member pathways
11.92 TNNT2 TNNI3 TNF IL6 ACE
6
Show member pathways
11.77 TNF IL6 IL1B F2 CRP ALB
7 11.76 TNF IL6 IL1B F3
8 11.73 TNF IL6 IL1B CD4
9 11.71 TNF IL1B CD4
10 11.69 PRTN3 CD4 ADA
11 11.69 TNF MEFV IL6 IL1B CD4
12 11.67 TNF IL6 IL1B
13
Show member pathways
11.58 TNF IL6 IL1B
14 11.57 TNF IL6 IL1B
15
Show member pathways
11.55 TNF IL6 IL1B CD4
16 11.52 TNF IL6 IL1B
17 11.49 TNF IL6 IL1B CD4
18 11.45 TNF IL6 IL1B
19 11.43 TNF IL6 IL1B
20 11.39 TNF IL6 IL1B
21 11.28 TNF IL6 IL1B
22 11.23 TNF IL6 IL1B
23 11.18 TNF IL6 IL1B
24 11.14 TNF IL6 IL1B
25 10.86 TNF IL6 CRP
26 10.39 TNF IL6 IL1B CD4

GO Terms for Pericardium Disease

Cellular components related to Pericardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF REN PRTN3 PRG4 NPPB IL6
2 external side of plasma membrane GO:0009897 9.65 TNF F2 CD4 ADA ACE
3 extracellular space GO:0005615 9.44 TNF REN PRTN3 NPPB IL6 IL1B
4 troponin complex GO:0005861 9.37 TNNT2 TNNI3
5 cardiac myofibril GO:0097512 9.32 TNNT2 TNNI3
6 cardiac Troponin complex GO:1990584 9.16 TNNT2 TNNI3

Biological processes related to Pericardium Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.95 TNF MEFV IL6 IL1B CRP
2 positive regulation of protein phosphorylation GO:0001934 9.86 TNF IL1B F2 CD4
3 regulation of insulin secretion GO:0050796 9.76 TNF IL6 IL1B
4 regulation of blood pressure GO:0008217 9.75 REN NPPB ACE
5 positive regulation of T cell proliferation GO:0042102 9.74 IL6 IL1B CD4
6 acute-phase response GO:0006953 9.67 IL6 F2 CRP
7 positive regulation of JAK-STAT cascade GO:0046427 9.63 TNF IL6 F2
8 cytokine-mediated signaling pathway GO:0019221 9.63 TNF PRTN3 IL6 IL1B F3 CD4
9 positive regulation of interleukin-8 production GO:0032757 9.62 TNF IL6 IL1B F3
10 regulation of establishment of endothelial barrier GO:1903140 9.6 TNF IL1B
11 neutrophil mediated immunity GO:0002446 9.59 IL6 ACE
12 negative regulation of neurogenesis GO:0050768 9.58 TNF IL6 IL1B
13 germinal center B cell differentiation GO:0002314 9.54 IL6 ADA
14 positive regulation of glial cell proliferation GO:0060252 9.54 TNF IL6 IL1B
15 positive regulation of fever generation GO:0031622 9.52 TNF IL1B
16 sequestering of triglyceride GO:0030730 9.51 TNF IL1B
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 TNF IL1B
18 negative regulation of gap junction assembly GO:1903597 9.43 IL1B ACE
19 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL6 IL1B
20 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
21 vascular endothelial growth factor production GO:0010573 8.8 TNF IL6 IL1B

Molecular functions related to Pericardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 REN PRTN3 NPPB F2 CD4
2 troponin C binding GO:0030172 8.62 TNNT2 TNNI3

Sources for Pericardium Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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