MCID: PRC008
MIFTS: 27

Pericholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Pericholangitis

MalaCards integrated aliases for Pericholangitis:

Name: Pericholangitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14272
NCIt 50 C34916
SNOMED-CT 67 111373008
UMLS 70 C0031052

Summaries for Pericholangitis

MalaCards based summary : Pericholangitis is related to cholangitis, primary sclerosing and ulcerative colitis. An important gene associated with Pericholangitis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Drug metabolism - cytochrome P450. Affiliated tissues include liver, spleen and colon.

Related Diseases for Pericholangitis

Diseases related to Pericholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 cholangitis, primary sclerosing 29.6 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
2 ulcerative colitis 10.5
3 colitis 10.3
4 cholangitis 10.3
5 sclerosing cholangitis 10.3
6 autosomal dominant non-syndromic intellectual disability 3 10.2 ABCB4 ABCB11
7 cholestasis, progressive familial intrahepatic, 5 10.1 ABCB4 ABCB11
8 cholestasis, progressive familial intrahepatic, 4 10.1 ABCB4 ABCB11
9 common bile duct disease 10.1 ABCB4 ABCB11
10 chronic cholangitis 10.1 SLC51A ABCB4
11 bile duct cysts 10.1 ABCB4 ABCB11
12 cholestasis, intrahepatic, of pregnancy 3 10.1 ABCB4 ABCB11
13 bile acid synthesis defect, congenital, 2 10.1 SLC10A1 ABCB11
14 alagille syndrome 1 10.0 ABCB4 ABCB11
15 hepatitis d 10.0 SLC10A2 SLC10A1
16 familial intrahepatic cholestasis 9.9 SLC10A2 ABCB4 ABCB11
17 acetaminophen metabolism 9.9 UGT1A3 UGT1A10
18 hypercholesterolemia, familial, 1 9.9
19 cholangiocarcinoma 9.9
20 autoimmune hepatitis 9.9
21 intrahepatic cholangiocarcinoma 9.9
22 liver cirrhosis 9.9
23 bronchiectasis 9.9
24 cryptogenic cirrhosis 9.9
25 cholestasis, intrahepatic, of pregnancy, 1 9.9 SLC10A2 ABCB4 ABCB11
26 cholelithiasis 9.9 UGT1A3 ABCB4
27 sitosterolemia 9.8 ABCB4 ABCB11
28 primary biliary cholangitis 9.8 SLC51A ABCB4 ABCB11
29 extrahepatic cholestasis 9.8 SLC51A SLC10A1 ABCB4 ABCB11
30 heart defects, congenital, and other congenital anomalies 9.7 SLC51A SLC10A2 SLC10A1 ABCB11
31 cholestasis, benign recurrent intrahepatic, 2 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
32 cholestasis 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
33 cholestasis, progressive familial intrahepatic, 3 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
34 cholestasis, progressive familial intrahepatic, 2 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
35 cholestasis, progressive familial intrahepatic, 1 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
36 progressive familial intrahepatic cholestasis 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
37 bile duct disease 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
38 cholestasis, benign recurrent intrahepatic, 1 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
39 biliary tract disease 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
40 leber plus disease 9.5 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
41 kernicterus 9.4 UGT1A7 UGT1A5 UGT1A3 UGT1A10
42 bilirubin, serum level of, quantitative trait locus 1 9.4 UGT1A7 UGT1A5 UGT1A3 UGT1A10
43 biliary atresia 9.4 SPP1 SLC10A2 SLC10A1 ABCB4 ABCB11
44 crigler-najjar syndrome, type ii 9.4 UGT1A7 UGT1A5 UGT1A3 UGT1A10
45 hyperbilirubinemia, transient familial neonatal 9.4 UGT1A7 UGT1A5 UGT1A3 UGT1A10
46 gilbert syndrome 9.4 UGT1A7 UGT1A5 UGT1A3 UGT1A10
47 crigler-najjar syndrome, type i 9.2 UGT1A7 UGT1A5 UGT1A3 UGT1A10 ABCB11
48 hereditary spherocytosis 9.2 UGT1A7 UGT1A5 UGT1A3 UGT1A10 ABCB11
49 bilirubin metabolic disorder 8.4 UGT1A7 UGT1A5 UGT1A3 UGT1A10 SLC51A SLC10A2

Graphical network of the top 20 diseases related to Pericholangitis:



Diseases related to Pericholangitis

Symptoms & Phenotypes for Pericholangitis

Drugs & Therapeutics for Pericholangitis

Search Clinical Trials , NIH Clinical Center for Pericholangitis

Genetic Tests for Pericholangitis

Anatomical Context for Pericholangitis

MalaCards organs/tissues related to Pericholangitis:

40
Liver, Spleen, Colon, Appendix

Publications for Pericholangitis

Articles related to Pericholangitis:

(show top 50) (show all 107)
# Title Authors PMID Year
1
Isolation of Campylobacter hepaticus from free-range poultry with spotty liver disease in New Zealand. 61
32781921 2021
2
Transmammary transmission of Troglostrongylus brevior feline lungworm: a lesson from our gardens. 61
32862125 2020
3
Pathological Findings in Lowland Tapirs (Tapirus terrestris) Killed by Motor Vehicle Collision in the Brazilian Cerrado. 61
31375157 2019
4
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism. 61
28725001 2017
5
Prognostic value of clinical variables and liver histology for development of fibrosis and cirrhosis in autoimmune hepatitis. 61
27846740 2017
6
Fascioliasis simulating an intrahepatic cholangiocarcinoma-Case report with imaging and pathology correlation. 61
25713810 2015
7
Syphilis presenting as inflammatory tumors of the liver in HIV-positive homosexual men. 61
24921640 2014
8
Inflammatory angiomyolipoma of the liver: an unusual case suggesting relationship to IgG4-related pseudotumor. 61
23573326 2013
9
Host-parasite relationship of Ceratomyxa puntazzi n. sp. (Myxozoa: Myxosporea) and sharpsnout seabream Diplodus puntazzo (Walbaum, 1792) from the Mediterranean with first data on ceratomyxid host specificity in sparids. 61
21680098 2011
10
Acute and twenty-eight days repeated oral dose toxicity study of besifloxacin in Wistar albino rats. 61
21787734 2011
11
Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease. 61
20198712 2010
12
DNA damage, severe organ lesions and high muscle levels of As and Hg in two benthic fish species from a chemical warfare agent dumping site in the Mediterranean Sea. 61
20083295 2010
13
Effects of intraperitoneal melatonin on caustic sclerosing cholangitis due to scolicidal solution in a rat model. 61
24683258 2010
14
A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis. 61
17600122 2007
15
Phylogeny of Coccomyxa (Myxosporea: Myxidiidae) spp. with the description of a new species from Bathygobius cyclopterus (Gobiidae) in the northern Red Sea. 61
17886740 2007
16
Pathological findings in harbour porpoises (Phocoena phocoena) from Norwegian and Icelandic waters. 61
16527299 2006
17
Idiopathic fibrosing pancreatitis associated with ulcerative colitis. 61
18333266 2006
18
Cholangitis: a histologic classification based on patterns of injury in liver biopsies. 61
16259109 2005
19
IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis? 61
15316319 2004
20
Acute and subchronic mammalian toxicity of naphthenic acids from oil sands tailings. 61
11896302 2002
21
Value of magnetic resonance cholangiography (MRC) in primary sclerosing cholangitis (PSC). 61
12211704 2001
22
Variant forms of cholestatic diseases involving small bile ducts in adults. 61
10811317 2000
23
Decontamination of winter flounder (Pleuronectes americanus) following chronic exposure to effluent from a pulp and paper mill. 61
10629282 2000
24
Cytoprotective effects of trimetazidine in carmustine cholestasis. 61
10445391 1999
25
Hepatobiliary manifestations of inflammatory bowel disease. 61
10372279 1999
26
Clinical and pathologic evaluation of chronic Bartonella henselae or Bartonella clarridgeiae infection in cats. 61
10203518 1999
27
[Pericholangitis and primary sclerosing cholangitis]. 61
10364808 1999
28
[Extreme hypercholesterolemia with xanthomatous eruptions caused by HIV-associated pericholangitis]. 61
10049097 1998
29
Idiopathic adulthood ductopenia: an update. 61
9511789 1998
30
Pathological changes in yearly protocol liver biopsy specimens from healthy pediatric liver recipients. 61
9404953 1997
31
[Hepatobiliary complications of idiopathic intestinal inflammations]. 61
9221179 1997
32
[Fatal poisoning caused by oil of epazote, Chenopodium graveolens]. 61
8964384 1996
33
Pericholangitis in a rabbit colitis model induced by injection of muramyl dipeptide emulsified with a long-chain fatty acid. 61
8726825 1996
34
Extraintestinal manifestations of granulomatous enterocolitis induced in rabbits by long-term submucosal administration of muramyl dipeptide emulsified with Freund's incomplete adjuvant. 61
8680539 1996
35
Induction of chronic cholangitis in the rat by trinitrobenzenesulfonic acid. 61
7790710 1995
36
Acute toxicity of lipiodol infusion into the hepatic arteries of dogs. 61
7852039 1994
37
Small bile duct abnormalities and chronic intrahepatic cholestasis in Behçet's syndrome. 61
7959551 1994
38
Immunohistochemical demonstration of collagen types III and IV and myofibroblasts in the liver of patients with biliary atresia. 61
8035273 1994
39
Cholestatic hepatitis leading to hepatic failure in a patient with organ-transmitted hepatitis C virus infection. 61
8276189 1994
40
Pericholangitis and sclerosing cholangitis are risk factors for dysplasia and cancer in ulcerative colitis. 61
8338083 1993
41
Pericholangitis in patients with ulcerative colitis, and risk factors for progression to colorectal cancer. 61
8338079 1993
42
Hepatosplenic lesions induced by experimental Schistosoma malayensis in rabbits. 61
8266238 1993
43
Effect of methylprednisolone on small bowel, spleen and liver changes in a murine model of inflammatory bowel disease. 61
8485274 1993
44
Pericholangitis with ulcerative colitis following autoimmune hepatitis over 12 years. 61
1363077 1992
45
Fibrosing pancreatitis associated with pericholangitis and cholangitis in a child. 61
1403472 1992
46
Detection of liver involvement in inflammatory bowel disease by abdominal ultrasound scan. 61
1591385 1992
47
A model of inflammatory bowel disease induced by 2,4-dinitrofluorobenzene in previously sensitized BALB-c mice. 61
1502479 1992
48
Hepatobiliary cryptosporidiosis and cytomegalovirus infection mimicking metastatic cancer to the liver. 61
1850377 1991
49
Small-duct primary sclerosing cholangitis. 61
2047885 1991
50
Nitrosoureas lomustine, carmustine and fotemustine induced hepatotoxic perturbations in rats: biochemical, morphological and flow cytometry studies. 61
1828975 1991

Variations for Pericholangitis

Expression for Pericholangitis

Search GEO for disease gene expression data for Pericholangitis.

Pathways for Pericholangitis

Pathways related to Pericholangitis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 UGT1A7 UGT1A5 UGT1A3 UGT1A10 SLC10A2 SLC10A1
2
Show member pathways
12.54 UGT1A7 UGT1A5 UGT1A3 UGT1A10
3 12.25 UGT1A7 UGT1A5 UGT1A3 UGT1A10
4
Show member pathways
11.94 SLC10A2 SLC10A1 ABCB11
5
Show member pathways
11.93 UGT1A7 UGT1A5 UGT1A3 UGT1A10
6
Show member pathways
11.87 UGT1A7 UGT1A5 UGT1A3 UGT1A10
7
Show member pathways
11.75 SLC10A1 ABCB4 ABCB11
8
Show member pathways
11.38 UGT1A7 UGT1A3 UGT1A10
9
Show member pathways
11.36 UGT1A3 UGT1A10
10
Show member pathways
11.31 UGT1A7 UGT1A5 UGT1A3 UGT1A10
11 11.24 UGT1A7 UGT1A3
12 11.23 UGT1A7 UGT1A5 UGT1A3 UGT1A10 SLC51A SLC10A2
13
Show member pathways
11.14 UGT1A3 UGT1A10
14 11.08 ABCB4 ABCB11
15
Show member pathways
11.08 UGT1A7 UGT1A5 UGT1A3 UGT1A10
16 10.78 SLC10A1 ABCB4 ABCB11
17 10.66 SLC51A SLC10A1 ABCB11

GO Terms for Pericholangitis

Cellular components related to Pericholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.06 UGT1A7 UGT1A5 UGT1A3 UGT1A10 SLC51A SLC10A2
2 endoplasmic reticulum GO:0005783 9.72 UGT1A7 UGT1A5 UGT1A3 UGT1A10 SLC51A
3 integral component of membrane GO:0016021 9.61 UGT1A7 UGT1A5 UGT1A3 UGT1A10 SLC51A SLC10A2
4 endoplasmic reticulum membrane GO:0005789 9.55 UGT1A7 UGT1A5 UGT1A3 UGT1A10 SLC51A
5 apical plasma membrane GO:0016324 9.54 SLC10A2 ABCB4 ABCB11
6 basolateral plasma membrane GO:0016323 9.43 SLC51A SLC10A1 ABCB11
7 intercellular canaliculus GO:0046581 8.62 ABCB4 ABCB11

Biological processes related to Pericholangitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.77 SLC51A SLC10A2 SLC10A1 ABCB4 ABCB11
2 cellular glucuronidation GO:0052695 9.5 UGT1A7 UGT1A3 UGT1A10
3 lipid homeostasis GO:0055088 9.49 ABCB4 ABCB11
4 estrogen metabolic process GO:0008210 9.48 UGT1A7 UGT1A3
5 drug metabolic process GO:0017144 9.46 UGT1A7 ABCB11
6 bile acid and bile salt transport GO:0015721 9.46 SLC51A SLC10A2 SLC10A1 ABCB11
7 retinoic acid metabolic process GO:0042573 9.43 UGT1A7 UGT1A3
8 bile acid secretion GO:0032782 9.43 UGT1A3 SLC51A ABCB4
9 flavone metabolic process GO:0051552 9.4 UGT1A7 UGT1A10
10 xenobiotic glucuronidation GO:0052697 9.26 UGT1A7 UGT1A5 UGT1A3 UGT1A10
11 flavonoid glucuronidation GO:0052696 8.92 UGT1A7 UGT1A5 UGT1A3 UGT1A10

Molecular functions related to Pericholangitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.73 UGT1A7 UGT1A3 UGT1A10 SLC51A
2 protein heterodimerization activity GO:0046982 9.71 UGT1A7 UGT1A3 UGT1A10 SLC51A
3 transferase activity, transferring glycosyl groups GO:0016757 9.62 UGT1A7 UGT1A5 UGT1A3 UGT1A10
4 protein kinase C binding GO:0005080 9.49 UGT1A7 UGT1A10
5 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.48 ABCB4 ABCB11
6 transporter activity GO:0005215 9.46 SLC51A ABCB11
7 retinoic acid binding GO:0001972 9.43 UGT1A7 UGT1A3 UGT1A10
8 bile acid:sodium symporter activity GO:0008508 9.37 SLC10A2 SLC10A1
9 bile acid transmembrane transporter activity GO:0015125 9.33 SLC51A SLC10A1 ABCB11
10 glucuronosyltransferase activity GO:0015020 9.26 UGT1A7 UGT1A5 UGT1A3 UGT1A10
11 UDP-glycosyltransferase activity GO:0008194 8.92 UGT1A7 UGT1A5 UGT1A3 UGT1A10

Sources for Pericholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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