MCID: PRC008
MIFTS: 28

Pericholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Pericholangitis

MalaCards integrated aliases for Pericholangitis:

Name: Pericholangitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14272
NCIt 50 C34916
SNOMED-CT 68 111373008
UMLS 73 C0031052

Summaries for Pericholangitis

MalaCards based summary : Pericholangitis is related to colitis and ulcerative colitis. An important gene associated with Pericholangitis is UGT1A5 (UDP Glucuronosyltransferase Family 1 Member A5), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. Affiliated tissues include liver, lung and colon, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Pericholangitis

Diseases related to Pericholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 colitis 10.4
2 ulcerative colitis 10.4
3 cholangitis 10.1
4 sclerosing cholangitis 10.1
5 hepatitis 9.9
6 pancreatitis 9.9
7 colorectal cancer 9.8
8 cholangitis, primary sclerosing 9.8
9 cholangiocarcinoma 9.8
10 autoimmune hepatitis 9.8
11 placenta disease 9.8
12 bronchiectasis 9.8
13 acetaminophen metabolism 9.4 UGT1A10 UGT1A3
14 gilbert syndrome 8.3 UGT1A10 UGT1A3 UGT1A4 UGT1A8
15 bilirubin, serum level of, quantitative trait locus 1 8.0 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
16 crigler-najjar syndrome, type ii 7.9 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8

Graphical network of the top 20 diseases related to Pericholangitis:



Diseases related to Pericholangitis

Symptoms & Phenotypes for Pericholangitis

GenomeRNAi Phenotypes related to Pericholangitis according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.77 UGT1A4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.77 UGT1A5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.77 UGT1A4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.77 UGT1A5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.77 UGT1A4
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.77 UGT1A3 UGT1A4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.77 UGT1A5
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.77 UGT1A3 UGT1A4 UGT1A5
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.77 UGT1A4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.77 UGT1A5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.5 UGT1A4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.5 UGT1A3 UGT1A4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.5 UGT1A4
14 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.5 UGT1A3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.5 UGT1A3 UGT1A4
16 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.5 UGT1A5 UGT1A3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.5 UGT1A5
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.5 UGT1A5

Drugs & Therapeutics for Pericholangitis

Search Clinical Trials , NIH Clinical Center for Pericholangitis

Genetic Tests for Pericholangitis

Anatomical Context for Pericholangitis

MalaCards organs/tissues related to Pericholangitis:

41
Liver, Lung, Colon

Publications for Pericholangitis

Articles related to Pericholangitis:

(show all 20)
# Title Authors Year
1
Pericholangitis in a rabbit colitis model induced by injection of muramyl dipeptide emulsified with a long-chain fatty acid. ( 8726825 )
1996
2
Pericholangitis and sclerosing cholangitis are risk factors for dysplasia and cancer in ulcerative colitis. ( 8338083 )
1993
3
Pericholangitis in patients with ulcerative colitis, and risk factors for progression to colorectal cancer. ( 8338079 )
1993
4
Fibrosing pancreatitis associated with pericholangitis and cholangitis in a child. ( 1403472 )
1992
5
Pericholangitis with ulcerative colitis following autoimmune hepatitis over 12 years. ( 1363077 )
1992
6
Chronic postcolectomy pericholangitis and cholangiocarcinoma. ( 2995479 )
1985
7
Pericholangitis in chronic ulcerative colitis: primary sclerosing cholangitis of the small bile ducts? ( 3985511 )
1985
8
Carcinoma of the colon, sclerosing cholangitis, pericholangitis, and bronchiectasis in a patient with chronic ulcerative colitis. ( 6481120 )
1984
9
Pancreatic insufficiency associated with ulcerative colitis and pericholangitis. ( 7054051 )
1982
10
Cholangiographic abnormalities in ulcerative colitis associated pericholangitis which resemble sclerosing cholangitis. ( 685922 )
1978
11
Acute pericholangitis as the initial manifestation of fulminant ulcerative colitis. ( 4636298 )
1972
12
A case of hepatic granulomas associated with secondary pericholangitis, with a reference to the significance of enzyme activity in the serum and the liver tissue. ( 5155628 )
1971
13
Chronic ulcerative colitis and pericholangitis. ( 5427620 )
1970
14
Term pregnancy complicated by cirrhosis secondary to chronic pericholangitis. ( 5300440 )
1968
15
PERICHOLANGITIS AND ULCERATIVE COLITIS. II. CLINICAL ASPECTS. ( 14305965 )
1965
16
PERICHOLANGITIS AND ULCERATIVE COLITIS. I. PATHOLOGY, ETIOLOGY, AND PATHOGENESIS. ( 14305966 )
1965
17
Effect of long-term tetracycline therapy, steroid therapy and colectomy in pericholangitis associated with ulcerative colitis. ( 5861251 )
1965
18
SERUM 5-NUCLEOTIDASE AND PERICHOLANGITIS IN PATIENTS WITH CHRONIC ULCERATIVE COLITIS. ( 14070422 )
1963
19
The liver in ulcerative colitis; treatment of pericholangitis with tetracycline. ( 14436189 )
1959
20
Honeycomb lungs with pericholangitis. ( 13831410 )
1959

Variations for Pericholangitis

Expression for Pericholangitis

Search GEO for disease gene expression data for Pericholangitis.

Pathways for Pericholangitis

Pathways related to Pericholangitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 SLC10A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
2
Show member pathways
12.88 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
3
Show member pathways
12.52 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
4 12.29 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
5
Show member pathways
12.01 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
6 11.72 UGT1A3 UGT1A4
7
Show member pathways
11.57 UGT1A10 UGT1A3 UGT1A4 UGT1A8
8
Show member pathways
11.45 UGT1A3 UGT1A4
9
Show member pathways
11.41 UGT1A10 UGT1A3 UGT1A4 UGT1A8
10 11.22 UGT1A3 UGT1A4
11
Show member pathways
11.2 UGT1A10 UGT1A3 UGT1A4 UGT1A8
12
Show member pathways
11.16 UGT1A3 UGT1A4 UGT1A8
13 11.02 UGT1A3 UGT1A4
14
Show member pathways
10.83 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
15 10.64 UGT1A3 UGT1A4
16 10.58 UGT1A10 UGT1A3 UGT1A4 UGT1A8

GO Terms for Pericholangitis

Cellular components related to Pericholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.63 SLC10A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
2 endoplasmic reticulum GO:0005783 9.56 UGT1A10 UGT1A3 UGT1A4 UGT1A8
3 endoplasmic reticulum membrane GO:0005789 9.35 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
4 intracellular membrane-bounded organelle GO:0043231 9.02 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8

Biological processes related to Pericholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.65 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
2 retinoic acid metabolic process GO:0042573 9.37 UGT1A3 UGT1A8
3 xenobiotic glucuronidation GO:0052697 9.35 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
4 cellular glucuronidation GO:0052695 9.33 UGT1A10 UGT1A3 UGT1A4
5 flavone metabolic process GO:0051552 9.32 UGT1A10 UGT1A8
6 flavonoid glucuronidation GO:0052696 9.02 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8

Molecular functions related to Pericholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.8 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
2 protein homodimerization activity GO:0042803 9.73 UGT1A10 UGT1A3 UGT1A4 UGT1A8
3 transferase activity, transferring glycosyl groups GO:0016757 9.72 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
4 protein heterodimerization activity GO:0046982 9.67 UGT1A10 UGT1A3 UGT1A4 UGT1A8
5 retinoic acid binding GO:0001972 9.56 UGT1A10 UGT1A3 UGT1A4 UGT1A8
6 transferase activity, transferring hexosyl groups GO:0016758 9.55 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
7 glucuronosyltransferase activity GO:0015020 9.35 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8
8 UDP-glycosyltransferase activity GO:0008194 9.02 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A8

Sources for Pericholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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