Aliases & Classifications for Pericoronitis

MalaCards integrated aliases for Pericoronitis:

Name: Pericoronitis 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3671
MeSH 44 D010497
SNOMED-CT 68 22240003
UMLS 73 C0031055

Summaries for Pericoronitis

MalaCards based summary : Pericoronitis is related to amelogenesis imperfecta, type ig and familial cold autoinflammatory syndrome 1. An important gene associated with Pericoronitis is CTRL (Chymotrypsin Like), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone and Antiemetics have been mentioned in the context of this disorder. Affiliated tissues include tonsil and bone, and related phenotype is immune system.

Wikipedia : 76 Pericoronitis (from the Greek peri, \"around\", Latin corona \"crown\" and -itis, \"inflammation\") also... more...

Related Diseases for Pericoronitis

Diseases related to Pericoronitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta, type ig 11.0
2 familial cold autoinflammatory syndrome 1 10.7 IL1B TNFRSF1A
3 uremic pruritus 10.6 CRP IL1B
4 suppurative otitis media 10.6 CRP IL1B
5 hyper-igd syndrome 10.6 CRP TNFRSF1A
6 central nervous system vasculitis 10.6 CRP IL1B
7 relapsing fever 10.6 CRP TNFRSF1A
8 aseptic meningitis 10.5 CD2 IL1B
9 limbal stem cell deficiency 10.5 IL1B VCAM1
10 pharyngitis 10.5 CRP IL1B
11 cortical thymoma 10.5 CD2 VCAM1
12 scrub typhus 10.5 CRP IL1B
13 chronic gonococcal salpingitis 10.5 TNFRSF1A TNFRSF1B
14 pleural disease 10.5 CRP IL1B
15 adult-onset still's disease 10.4 CRP IL1B
16 extracutaneous mastocytoma 10.4 CD2 CD68
17 periodic fever, familial, autosomal dominant 10.4 TNFRSF1A TNFRSF1B
18 sciatic neuropathy 10.4 TNFRSF1A TNFRSF1B
19 perinatal necrotizing enterocolitis 10.4 CRP IL1B
20 short-rib thoracic dysplasia 5 with or without polydactyly 10.4 TNFRSF1A TNFRSF1B
21 eumycotic mycetoma 10.4 CD68 IL1B
22 acute salpingitis 10.4 TNFRSF1A TNFRSF1B
23 tenosynovitis 10.4 CRP TNFRSF1B
24 post-transplant lymphoproliferative disease 10.4 TNFRSF1A TNFRSF1B
25 chronic salpingitis 10.3 TNFRSF1A TNFRSF1B
26 pneumatosis cystoides intestinalis 10.3 CD68 CRP
27 lobomycosis 10.3 CD19 CD2
28 mesenteric lymphadenitis 10.3 CD68 CRP
29 uterine anomalies 10.3 CRP IL1B
30 viral encephalitis 10.3 IL1B VCAM1
31 mouth disease 10.3 CRP CTRL IL1B
32 xanthogranulomatous pyelonephritis 10.3 CD68 CRP
33 muckle-wells syndrome 10.3 CRP IL1B TNFRSF1A
34 leptospirosis 10.2 CRP IL1B
35 wells syndrome 10.2 CRP IL1B TNFRSF1A
36 pericarditis 10.2 CRP IL1B TNFRSF1A
37 familial mediterranean fever 10.2 CRP IL1B TNFRSF1A
38 calcific tendinitis 10.2 CD68 CRP
39 venous insufficiency 10.2 CRP VCAM1
40 granulomatous hepatitis 10.2 CRP TNFRSF1B
41 actinic prurigo 10.2 CD2 IL1B VCAM1
42 pericardial effusion 10.1 CRP TNFRSF1A
43 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 CRP IL1B VCAM1
44 rheumatic disease 10.1 CRP IL1B VCAM1
45 synovitis 10.1 CRP IL1B VCAM1
46 arteries, anomalies of 10.1 CRP IL1B VCAM1
47 exanthem 10.1 CRP TNFRSF1B
48 lethal midline granuloma 10.1 CD2 NCAM1
49 peripheral artery disease 10.0 CRP VCAM1
50 primary bacterial infectious disease 10.0 CRP IL1B TNFRSF1B

Graphical network of the top 20 diseases related to Pericoronitis:



Diseases related to Pericoronitis

Symptoms & Phenotypes for Pericoronitis

MGI Mouse Phenotypes related to Pericoronitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CD19 CD68 CRP IL1B TNFRSF1A TNFRSF1B

Drugs & Therapeutics for Pericoronitis

Drugs for Pericoronitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2 Antiemetics Phase 4
3 Anti-Inflammatory Agents Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 Autonomic Agents Phase 4
6 BB 1101 Phase 4
7 Dexamethasone acetate Phase 4 1177-87-3
8 Gastrointestinal Agents Phase 4
9 glucocorticoids Phase 4
10 HIV Protease Inhibitors Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Peripheral Nervous System Agents Phase 4
15
protease inhibitors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparing Pain and Swelling After Surgical Extraction of Mandibular Third Molar in Dexamethasone Injection and Without Corticosteroid Methods Unknown status NCT01896427 Phase 4 21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione
2 Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Recruiting NCT03469232 Phase 1, Phase 2 Huanglian-Jiedu Decoction
3 The Effects of Active Surveillance Protocol on Long Term Quality of Life in Patients With Mild Pericoronitis Completed NCT03027622
4 Third Molar Clinical Trials: Pericoronitis Studies Completed NCT01882270
5 Evaluation of Photodynamic Therapy in Pericoronitis Not yet recruiting NCT03576105 Not Applicable

Search NIH Clinical Center for Pericoronitis

Cochrane evidence based reviews: pericoronitis

Genetic Tests for Pericoronitis

Anatomical Context for Pericoronitis

MalaCards organs/tissues related to Pericoronitis:

41
Tonsil, Bone

Publications for Pericoronitis

Articles related to Pericoronitis:

(show top 50) (show all 88)
# Title Authors Year
1
Clinical and histological evaluation of the efficacy of antimicrobial photodynamic therapy used in addition to antibiotic therapy in pericoronitis treatment. ( 29486353 )
2018
2
Application of Denaturing Gradient Gel Electrophoresis to the Analysis of Bacterial Communities Associated With Asymptomatic and Symptomatic Pericoronitis. ( 28893542 )
2017
3
Is the Level of Nitric Oxide in the Dental Follicular Tissues of Impacted Third Molars With a History of Recurrent Pericoronitis a True Marker of Oxidative Stress? ( 28495408 )
2017
4
Herpesviral-bacterial co-infection in mandibular third molar pericoronitis. ( 27620215 )
2016
5
Treatment of mandibular third molars and pericoronitis in British military personnel: influence of guidelines from the National Institute for Health and Clinical Excellence. ( 27568572 )
2016
6
Non-third molar related pericoronitis in a sub-urban Nigeria population of children. ( 24326801 )
2014
7
Evaluation of periodontal pathogens of the mandibular third molar pericoronitis by using real time PCR. ( 24835305 )
2014
8
Effectiveness of green tea mouthwash in comparison to chlorhexidine mouthwash in patients with acute pericoronitis: a randomized clinical trial. ( 24954134 )
2014
9
Effect of quality of life measures on the decision to remove third molars in subjects with mild pericoronitis symptoms. ( 24836419 )
2014
10
An impacted mandibular left third molar and pericoronitis in a human immunodeficiency virus-positive patient. ( 25359647 )
2014
11
Pain With Pericoronitis Affects Quality of Life. ( 25262404 )
2014
12
Osteomyelitis of the condyle secondary to pericoronitis of a third molar: a case and literature review. ( 24819410 )
2014
13
Comparison of buccal infiltration of 4% articaine with 1a88:a88100,000 and 1a88:a88200,000 epinephrine for extraction of maxillary third molars with pericoronitis: a pilot study. ( 23763558 )
2013
14
Managing a patient with pericoronitis. ( 24309052 )
2013
15
Effects of low-level laser therapy as an adjunct to standard therapy in acute pericoronitis, and its impact on oral health-related quality of life. ( 22974370 )
2012
16
Large pericoronal radiolucency. Odontogenic myxoma. ( 23424746 )
2012
17
Multiple impacted teeth and associated pericoronal tissue abnormality in tuberous sclerosis complex. ( 22285332 )
2012
18
Quality of life outcomes after third molar removal in subjects with minor symptoms of pericoronitis. ( 22868034 )
2012
19
Osteomyelitis of the mandible secondary to pericoronitis of an impacted third molar. ( 20415010 )
2010
20
Bone resorption in incompletely impacted mandibular third molars and acute pericoronitis. ( 23674899 )
2009
21
Angulation of mandibular third molars as a predictive factor for pericoronitis. ( 19430626 )
2009
22
Oral anomalies associated with the oculocerebrorenal syndrome of Lowe: case report with multiple unerupted teeth and pericoronal radiolucencies. ( 19217010 )
2009
23
Comparison of periodontal inflammatory disease in young adults with and without pericoronitis involving mandibular third molars. ( 19070759 )
2009
24
Pericoronitis: treatment and a clinical dilemma. ( 19753908 )
2009
25
Impact of symptomatic pericoronitis on health-related quality of life. ( 19022127 )
2008
26
Pericoronal radiolucency with radiopacities of posterior mandible. Ameloblastic fibro-odontoma. ( 18810922 )
2008
27
The relationship between pericoronitis, wisdom teeth, putative periodontal pathogens and the host response. ( 18649731 )
2008
28
Pericoronitis as an initial manifestation of acute lymphoblastic leukemia: a case report. ( 18355610 )
2008
29
The predictivity of mandibular third molar position as a risk indicator for pericoronitis. ( 17619915 )
2008
30
A retrospective study of some socio-demograhic factors associated with pericoronitis in Nigerians. ( 18705431 )
2007
31
Is malaria a predisposing factor for third molar pericoronitis in the tropics? ( 16269183 )
2006
32
Role of TNF-alpha and its receptors in pericoronitis. ( 16304450 )
2005
33
Anatomical considerations for the spread of odontogenic infection originating from the pericoronitis of impacted mandibular third molar: computed tomographic analyses. ( 15529132 )
2004
34
Flow-cytometric analysis of T-lymphocyte subsets after different treatment methods in patients with pericoronitis. ( 12618998 )
2003
35
Microbiology of mandibular third molar pericoronitis: incidence of beta-lactamase-producing bacteria. ( 12789143 )
2003
36
The predisposing factors of pericoronitis of mandibular third molars in a Jordanian population. ( 12731606 )
2003
37
Evaluation of the mandibular third molar pericoronitis flora and its susceptibility to different antibiotics prescribed in france. ( 14662986 )
2003
38
Bilateral pleural empyema following pericoronitis. ( 17264561 )
2001
39
Investigation of infectious organisms causing pericoronitis of the mandibular third molar. ( 10847281 )
2000
40
Intracoronal radiolucency in an incompletely erupted permanent molar with a diagnosis of pericoronitis: importance of radiographic examination. ( 9574958 )
1998
41
Clinical/biological outcomes of treatment for pericoronitis. ( 8859232 )
1996
42
Pericoronitis, deep fascial space infections, and the impacted third molar. ( 9462056 )
1996
43
Pericoronitis as a cause of tonsillitis. ( 8961986 )
1996
44
Pericoronitis and tonsillitis: clinical and darkfield microscopy findings. ( 8734697 )
1996
45
Bacteriologic findings in tonsillitis and pericoronitis. ( 8816129 )
1996
46
Respiratory tract infections and concomitant pericoronitis of the wisdom teeth. ( 7711620 )
1995
47
Microbiology of the pericoronal pouch in mandibular third molar pericoronitis. ( 8265205 )
1993
48
Pericoronitis and accidental paracetamol overdose: a cautionary tale. ( 8422319 )
1993
49
Cystic compound odontoma in an unusual pericoronal posterior location. ( 8191964 )
1993
50
Malignant lymphoma presenting as pericoronitis. A case report. ( 1453030 )
1992

Variations for Pericoronitis

Expression for Pericoronitis

Search GEO for disease gene expression data for Pericoronitis.

Pathways for Pericoronitis

Pathways related to Pericoronitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 CD19 CD68 CRP IL1B NCAM1 TNFRSF1A
2
Show member pathways
13.08 IL1B NCAM1 TNFRSF1A TNFRSF1B VCAM1
3
Show member pathways
12.27 IL1B TNFRSF1A TNFRSF1B
4 11.87 CD2 NCAM1 VCAM1
5 11.84 IL1B TNFRSF1A VCAM1
6
Show member pathways
11.79 CD2 IL1B TNFRSF1A TNFRSF1B
7 11.73 IL1B TNFRSF1B VCAM1
8 11.68 CD19 CD2 IL1B NCAM1 TNFRSF1A TNFRSF1B
9 11.62 CD19 CD2 IL1B
10 11.62 CD19 CD2 CD68 NCAM1
11 11.59 IL1B TNFRSF1A VCAM1
12 11.49 IL1B TNFRSF1A TNFRSF1B VCAM1
13 11.45 CD19 IL1B NCAM1
14
Show member pathways
11.34 IL1B TNFRSF1A VCAM1
15 11.19 IL1B TNFRSF1A TNFRSF1B
16 11.15 IL1B VCAM1
17 11.14 IL1B NCAM1
18 11.11 TNFRSF1A TNFRSF1B
19 11.09 TNFRSF1A TNFRSF1B
20 11.04 TNFRSF1A TNFRSF1B
21 10.89 IL1B VCAM1
22 10.34 CD68 IL1B VCAM1

GO Terms for Pericoronitis

Cellular components related to Pericoronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 CD2 CRP IL1B NCAM1 TNFRSF1A TNFRSF1B
2 cell surface GO:0009986 9.26 CD2 NCAM1 TNFRSF1A VCAM1
3 external side of plasma membrane GO:0009897 8.92 CD19 CD2 NCAM1 VCAM1

Biological processes related to Pericoronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.71 CD2 IL1B TNFRSF1A TNFRSF1B
2 inflammatory response GO:0006954 9.62 CRP IL1B TNFRSF1A TNFRSF1B
3 cytokine-mediated signaling pathway GO:0019221 9.56 IL1B TNFRSF1A TNFRSF1B VCAM1
4 cellular response to organic substance GO:0071310 9.43 CD68 IL1B
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.37 IL1B TNFRSF1B
6 cell surface receptor signaling pathway GO:0007166 9.26 CD19 CD2 TNFRSF1A TNFRSF1B
7 regulation of establishment of endothelial barrier GO:1903140 9.16 IL1B TNFRSF1A
8 response to lipopolysaccharide GO:0032496 8.92 IL1B TNFRSF1A TNFRSF1B VCAM1

Molecular functions related to Pericoronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF1A TNFRSF1B

Sources for Pericoronitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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