Aliases & Classifications for Pericoronitis

MalaCards integrated aliases for Pericoronitis:

Name: Pericoronitis 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3671
MeSH 44 D010497
SNOMED-CT 68 22240003
UMLS 73 C0031055

Summaries for Pericoronitis

MalaCards based summary : Pericoronitis is related to amelogenesis imperfecta, type ig and familial cold autoinflammatory syndrome 1. An important gene associated with Pericoronitis is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include tonsil, bone and lung, and related phenotypes are cardiovascular system and immune system

Wikipedia : 76 Pericoronitis (from the Greek peri, "around", Latin corona "crown" and -itis, "inflammation") also known... more...

Related Diseases for Pericoronitis

Diseases related to Pericoronitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta, type ig 11.1
2 familial cold autoinflammatory syndrome 1 10.2 IL1B TNFRSF1A
3 burns 10.2 CRP IL1B
4 schnitzler syndrome 10.2 CRP IL1B
5 uremic pruritus 10.2 CRP IL1B
6 typhoid fever 10.2 CRP IL1B
7 suppurative otitis media 10.2 CRP IL1B
8 rheumatoid lung disease 10.2 IL1B TNFRSF1B
9 central nervous system vasculitis 10.2 CRP IL1B
10 hyper-igd syndrome 10.2 CRP TNFRSF1A
11 paratyphoid fever 10.2 CRP TNFRSF1A
12 pyelonephritis 10.2 CRP IL1B
13 relapsing fever 10.2 CRP TNFRSF1A
14 chronic gonococcal salpingitis 10.2 TNFRSF1A TNFRSF1B
15 pharyngitis 10.2 CRP IL1B
16 extracutaneous mastocytoma 10.1 CD2 CD68
17 scrub typhus 10.1 CRP IL1B
18 cortical thymoma 10.1 CD2 VCAM1
19 periodic fever, familial, autosomal dominant 10.1 TNFRSF1A TNFRSF1B
20 sciatic neuropathy 10.1 TNFRSF1A TNFRSF1B
21 tenosynovitis 10.1 CRP TNFRSF1B
22 short-rib thoracic dysplasia 5 with or without polydactyly 10.1 TNFRSF1A TNFRSF1B
23 limbal stem cell deficiency 10.1 IL1B VCAM1
24 perinatal necrotizing enterocolitis 10.1 CRP IL1B
25 post-transplant lymphoproliferative disease 10.1 TNFRSF1A TNFRSF1B
26 osteomyelitis 10.1
27 tonsillitis 10.1
28 chronic salpingitis 10.1 TNFRSF1A TNFRSF1B
29 sideroblastic anemia with b-cell immunodeficiency, periodic fevers, and developmental delay 10.1 CD19 IL1B
30 eumycotic mycetoma 10.1 CD68 IL1B
31 lobomycosis 10.1 CD19 CD2
32 extrinsic cardiomyopathy 10.1 CRP IL1B
33 pleural disease 10.1 CRP IL1B
34 erythema elevatum diutinum 10.1 CD68 TNFRSF1B
35 mesenteric lymphadenitis 10.1 CD68 CRP
36 xanthogranulomatous pyelonephritis 10.1 CD68 CRP
37 pneumatosis cystoides intestinalis 10.1 CD68 CRP
38 lymph node disease 10.1 CRP IL1B
39 viral encephalitis 10.1 IL1B VCAM1
40 granulomatous angiitis 10.1 CD68 CRP
41 muckle-wells syndrome 10.1 CRP IL1B TNFRSF1A
42 wells syndrome 10.1 CRP IL1B TNFRSF1A
43 adult-onset still's disease 10.1 CRP IL1B TNFRSF1A
44 henoch-schoenlein purpura 10.1 CRP VCAM1
45 pericarditis 10.1 CRP IL1B TNFRSF1A
46 familial mediterranean fever 10.1 CRP IL1B TNFRSF1A
47 exanthem 10.1 CRP TNFRSF1B
48 calcific tendinitis 10.1 CD68 CRP
49 venous insufficiency 10.0 CRP VCAM1
50 leptospirosis 10.0 CRP IL1B

Graphical network of the top 20 diseases related to Pericoronitis:



Diseases related to Pericoronitis

Symptoms & Phenotypes for Pericoronitis

MGI Mouse Phenotypes related to Pericoronitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CD19 CRP IL1B TNFRSF1A TNFRSF1B VCAM1
2 immune system MP:0005387 9.17 CD19 CD68 CRP IL1B TNFRSF1A TNFRSF1B

Drugs & Therapeutics for Pericoronitis

Drugs for Pericoronitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3 Anti-Inflammatory Agents Phase 4
4
protease inhibitors Phase 4
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Hormone Antagonists Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 glucocorticoids Phase 4
10 Hormones Phase 4
11 Autonomic Agents Phase 4
12 HIV Protease Inhibitors Phase 4
13 BB 1101 Phase 4
14 Antiemetics Phase 4
15 Gastrointestinal Agents Phase 4
16 Chinese Skullcap Phase 1, Phase 2
17 Skullcap Phase 1, Phase 2
18
Methylene blue Approved, Investigational Not Applicable 61-73-4
19 Photosensitizing Agents Not Applicable
20 Dermatologic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparing Pain and Swelling After Surgical Extraction of Mandibular Third Molar in Dexamethasone Injection and Without Corticosteroid Methods Unknown status NCT01896427 Phase 4 21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione
2 Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life Completed NCT03745599 Phase 4 Diclofenac;Flurbiprofen;Benzydamine
3 Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Recruiting NCT03469232 Phase 1, Phase 2 Huanglian-Jiedu Decoction
4 The Effects of Active Surveillance Protocol on Long Term Quality of Life in Patients With Mild Pericoronitis Completed NCT03027622
5 Third Molar Clinical Trials: Pericoronitis Studies Completed NCT01882270
6 Evaluation of Photodynamic Therapy in Pericoronitis Not yet recruiting NCT03576105 Not Applicable

Search NIH Clinical Center for Pericoronitis

Cochrane evidence based reviews: pericoronitis

Genetic Tests for Pericoronitis

Anatomical Context for Pericoronitis

MalaCards organs/tissues related to Pericoronitis:

41
Tonsil, Bone, Lung, Lymph Node, B Cells, Myeloid, Nk Cells

Publications for Pericoronitis

Articles related to Pericoronitis:

(show top 50) (show all 84)
# Title Authors Year
1
Clinical and histological evaluation of the efficacy of antimicrobial photodynamic therapy used in addition to antibiotic therapy in pericoronitis treatment. ( 29486353 )
2018
2
Third molar pericoronitis in neutropenia. ( 30101065 )
2018
3
The predictivity of mandibular third molar position as a risk indicator for pericoronitis: A prospective study. ( 30546238 )
2018
4
Application of Denaturing Gradient Gel Electrophoresis to the Analysis of Bacterial Communities Associated With Asymptomatic and Symptomatic Pericoronitis. ( 28893542 )
2017
5
Is the Level of Nitric Oxide in the Dental Follicular Tissues of Impacted Third Molars With a History of Recurrent Pericoronitis a True Marker of Oxidative Stress? ( 28495408 )
2017
6
Herpesviral-bacterial co-infection in mandibular third molar pericoronitis. ( 27620215 )
2016
7
Treatment of mandibular third molars and pericoronitis in British military personnel: influence of guidelines from the National Institute for Health and Clinical Excellence. ( 27568572 )
2016
8
Non-third molar related pericoronitis in a sub-urban Nigeria population of children. ( 24326801 )
2014
9
Evaluation of periodontal pathogens of the mandibular third molar pericoronitis by using real time PCR. ( 24835305 )
2014
10
Effectiveness of green tea mouthwash in comparison to chlorhexidine mouthwash in patients with acute pericoronitis: a randomized clinical trial. ( 24954134 )
2014
11
Effect of quality of life measures on the decision to remove third molars in subjects with mild pericoronitis symptoms. ( 24836419 )
2014
12
An impacted mandibular left third molar and pericoronitis in a human immunodeficiency virus-positive patient. ( 25359647 )
2014
13
Pain With Pericoronitis Affects Quality of Life. ( 25262404 )
2014
14
Osteomyelitis of the condyle secondary to pericoronitis of a third molar: a case and literature review. ( 24819410 )
2014
15
Comparison of buccal infiltration of 4% articaine with 1a88:a88100,000 and 1a88:a88200,000 epinephrine for extraction of maxillary third molars with pericoronitis: a pilot study. ( 23763558 )
2013
16
Managing a patient with pericoronitis. ( 24309052 )
2013
17
Effects of low-level laser therapy as an adjunct to standard therapy in acute pericoronitis, and its impact on oral health-related quality of life. ( 22974370 )
2012
18
Quality of life outcomes after third molar removal in subjects with minor symptoms of pericoronitis. ( 22868034 )
2012
19
Osteomyelitis of the mandible secondary to pericoronitis of an impacted third molar. ( 20415010 )
2010
20
Bone resorption in incompletely impacted mandibular third molars and acute pericoronitis. ( 23674899 )
2009
21
Angulation of mandibular third molars as a predictive factor for pericoronitis. ( 19430626 )
2009
22
Comparison of periodontal inflammatory disease in young adults with and without pericoronitis involving mandibular third molars. ( 19070759 )
2009
23
Pericoronitis: treatment and a clinical dilemma. ( 19753908 )
2009
24
Impact of symptomatic pericoronitis on health-related quality of life. ( 19022127 )
2008
25
The relationship between pericoronitis, wisdom teeth, putative periodontal pathogens and the host response. ( 18649731 )
2008
26
Pericoronitis as an initial manifestation of acute lymphoblastic leukemia: a case report. ( 18355610 )
2008
27
The predictivity of mandibular third molar position as a risk indicator for pericoronitis. ( 17619915 )
2008
28
A retrospective study of some socio-demograhic factors associated with pericoronitis in Nigerians. ( 18705431 )
2007
29
Is malaria a predisposing factor for third molar pericoronitis in the tropics? ( 16269183 )
2006
30
Role of TNF-alpha and its receptors in pericoronitis. ( 16304450 )
2005
31
Anatomical considerations for the spread of odontogenic infection originating from the pericoronitis of impacted mandibular third molar: computed tomographic analyses. ( 15529132 )
2004
32
Flow-cytometric analysis of T-lymphocyte subsets after different treatment methods in patients with pericoronitis. ( 12618998 )
2003
33
Microbiology of mandibular third molar pericoronitis: incidence of beta-lactamase-producing bacteria. ( 12789143 )
2003
34
The predisposing factors of pericoronitis of mandibular third molars in a Jordanian population. ( 12731606 )
2003
35
Evaluation of the mandibular third molar pericoronitis flora and its susceptibility to different antibiotics prescribed in france. ( 14662986 )
2003
36
Bilateral pleural empyema following pericoronitis. ( 17264561 )
2001
37
Investigation of infectious organisms causing pericoronitis of the mandibular third molar. ( 10847281 )
2000
38
Intracoronal radiolucency in an incompletely erupted permanent molar with a diagnosis of pericoronitis: importance of radiographic examination. ( 9574958 )
1998
39
Clinical/biological outcomes of treatment for pericoronitis. ( 8859232 )
1996
40
Pericoronitis, deep fascial space infections, and the impacted third molar. ( 9462056 )
1996
41
Pericoronitis as a cause of tonsillitis. ( 8961986 )
1996
42
Pericoronitis and tonsillitis: clinical and darkfield microscopy findings. ( 8734697 )
1996
43
Bacteriologic findings in tonsillitis and pericoronitis. ( 8816129 )
1996
44
Respiratory tract infections and concomitant pericoronitis of the wisdom teeth. ( 7711620 )
1995
45
Microbiology of the pericoronal pouch in mandibular third molar pericoronitis. ( 8265205 )
1993
46
Pericoronitis and accidental paracetamol overdose: a cautionary tale. ( 8422319 )
1993
47
Malignant lymphoma presenting as pericoronitis. A case report. ( 1453030 )
1992
48
The mandibular third molar position as a predictive criteria for risk for pericoronitis: a retrospective study. ( 1603407 )
1992
49
Post-endodontic pericoronitis. ( 1291365 )
1992
50
Predominant cultivable flora in pericoronitis. ( 1820571 )
1991

Variations for Pericoronitis

Expression for Pericoronitis

Search GEO for disease gene expression data for Pericoronitis.

Pathways for Pericoronitis

Pathways related to Pericoronitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 CD19 CD68 CRP IL1B NCAM1 TNFRSF1A
2
Show member pathways
13.07 IL1B NCAM1 TNFRSF1A TNFRSF1B VCAM1
3 11.87 CD2 NCAM1 VCAM1
4 11.84 IL1B TNFRSF1A VCAM1
5
Show member pathways
11.81 CD2 IL1B TNFRSF1A TNFRSF1B
6 11.74 IL1B TNFRSF1B VCAM1
7 11.68 CD19 CD2 IL1B NCAM1 TNFRSF1A TNFRSF1B
8 11.64 CD19 CD2 IL1B
9 11.62 CD19 CD2 CD68 NCAM1
10 11.61 IL1B TNFRSF1A VCAM1
11 11.5 IL1B TNFRSF1A TNFRSF1B VCAM1
12 11.45 CD19 IL1B NCAM1
13
Show member pathways
11.34 IL1B TNFRSF1A VCAM1
14
Show member pathways
11.31 TNFRSF1A TNFRSF1B
15 11.3 IL1B VCAM1
16 11.19 IL1B TNFRSF1A TNFRSF1B
17 11.14 IL1B VCAM1
18 11.14 IL1B NCAM1
19 11.1 TNFRSF1A TNFRSF1B
20 11.08 TNFRSF1A TNFRSF1B
21 11.04 TNFRSF1A TNFRSF1B
22 10.89 IL1B VCAM1
23 10.34 CD68 IL1B VCAM1

GO Terms for Pericoronitis

Cellular components related to Pericoronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 CD2 NCAM1 TNFRSF1A VCAM1
2 external side of plasma membrane GO:0009897 9.26 CD19 CD2 NCAM1 VCAM1
3 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1A TNFRSF1B

Biological processes related to Pericoronitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.81 CD2 IL1B TNFRSF1A TNFRSF1B
2 inflammatory response GO:0006954 9.73 CRP IL1B TNFRSF1A TNFRSF1B
3 response to lipopolysaccharide GO:0032496 9.67 IL1B TNFRSF1B VCAM1
4 cytokine-mediated signaling pathway GO:0019221 9.67 IL1B TNFRSF1A TNFRSF1B VCAM1
5 cell surface receptor signaling pathway GO:0007166 9.62 CD19 CD2 TNFRSF1A TNFRSF1B
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.52 TNFRSF1A TNFRSF1B
7 negative regulation of cardiac muscle hypertrophy GO:0010614 9.48 TNFRSF1A TNFRSF1B
8 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 IL1B TNFRSF1B
9 regulation of establishment of endothelial barrier GO:1903140 9.4 IL1B TNFRSF1A
10 aortic valve development GO:0003176 9.26 TNFRSF1A TNFRSF1B
11 negative regulation of extracellular matrix constituent secretion GO:0003332 9.16 TNFRSF1A TNFRSF1B
12 positive regulation of apoptotic process involved in morphogenesis GO:1902339 8.96 TNFRSF1A TNFRSF1B
13 pulmonary valve development GO:0003177 8.62 TNFRSF1A TNFRSF1B

Molecular functions related to Pericoronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF1A TNFRSF1B
2 tumor necrosis factor binding GO:0043120 8.62 TNFRSF1A TNFRSF1B

Sources for Pericoronitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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