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NEC
MCID: PRN019
MIFTS: 57

Perinatal Necrotizing Enterocolitis (NEC)

Categories: Fetal diseases, Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Perinatal Necrotizing Enterocolitis

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MalaCards integrated aliases for Perinatal Necrotizing Enterocolitis:

Name: Perinatal Necrotizing Enterocolitis 12 15
Necrotizing Enterocolitis 12 53 59 15 73
Enterocolitis, Necrotizing 53 44
Enterocolitis Necrotizing 12 55
Necrotizing Enterocolitis in Fetus or Newborn 12
Pseudomembranous Enterocolitis in Newborn 12
Perinatal Necrotising Enterocolitis 12
Nec 53

Characteristics:

Orphanet epidemiological data:

59
necrotizing enterocolitis
Prevalence: 1-5/10000 (Worldwide); Age of onset: Neonatal; Age of death: infantile;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34 33


External Ids:

Disease Ontology 12 DOID:8677
ICD10 33 K55.3 K55.30 P77
MeSH 44 D020345
Orphanet 59 ORPHA391673
ICD10 via Orphanet 34 P77
UMLS via Orphanet 74 C0520459
UMLS 73 C0520459
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Summaries for Perinatal Necrotizing Enterocolitis

About this section
NIH Rare Diseases : 53 Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.

MalaCards based summary : Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to leukomalacia and cytomegalovirus infection. An important gene associated with Perinatal Necrotizing Enterocolitis is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Betamethasone and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and liver, and related phenotype is immune system.

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Related Diseases for Perinatal Necrotizing Enterocolitis

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Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 353)
# Related Disease Score Top Affiliating Genes
1 leukomalacia 30.1 IL6 TNF
2 cytomegalovirus infection 30.0 CXCL8 IL1B IL6 TNF
3 heart disease 30.0 CRP CXCL8 IL1B IL6 TNF
4 fasciitis 30.0 CXCL8 IL6 TNF
5 crohn's disease 29.9 CRP TLR9 TNF
6 appendicitis 29.8 CRP CXCL8 IL1B IL6 TNF
7 acute cystitis 29.8 CRP CXCL8 IL6
8 dengue shock syndrome 29.7 IL1B IL6 TNF
9 peritonitis 29.7 CRP CXCL8 IL1B IL6 TNF
10 multiple sclerosis 29.7 IL1B IL6 TLR9 TNF
11 pertussis 29.6 IL1B IL6 TLR4 TNF
12 bacterial sepsis 29.6 CRP CXCL8 TLR4 TNF
13 gastroenteritis 29.6 CRP CXCL8 IL1B IL6 TNF
14 colitis 29.5 CXCL8 IL1B IL6 TLR4 TLR9 TNF
15 meningitis 29.4 CRP CXCL8 IL1B IL6 TLR9 TNF
16 chorioamnionitis 29.4 CRP CXCL8 IL1B IL6 TLR4 TNF
17 inflammatory bowel disease 29.2 CRP CXCL8 IL1B IL6 TLR4 TLR9
18 intestinal disease 29.2 CRP CXCL8 IL1B IL6 TLR4 TLR9
19 short bowel syndrome 11.6
20 neuroendocrine carcinoma of pancreas 11.1
21 enterocolitis 10.7
22 autoinflammation with infantile enterocolitis 10.4
23 eye lymphoma 10.3 IL6 TLR9
24 gastroesophageal junction adenocarcinoma 10.3 IL1B TLR9
25 pouchitis 10.3 CXCL8 TLR4
26 denture stomatitis 10.2 CXCL8 IL6
27 papillary conjunctivitis 10.2 CXCL8 IL6
28 prosthetic joint infection 10.2 IL1B TLR4
29 acute transverse myelitis 10.2 CXCL8 IL6
30 folic acid deficiency anemia 10.2 CRP THPO
31 periodontitis, chronic 10.2 IL1B IL6
32 paraneoplastic syndromes 10.2 IL1B IL6
33 peptic esophagitis 10.2 CXCL8 IL1B
34 adult dermatomyositis 10.2 TLR9 TNF
35 acute cholangitis 10.2 CRP IL6
36 cold agglutinin disease 10.2 CRP IL6
37 cryopyrin-associated periodic syndrome 10.2 CRP IL6
38 trench fever 10.2 TLR4 TNF
39 myasthenic syndrome, congenital, 1a, slow-channel 10.2 CRP CXCL8
40 pyuria 10.2 CRP CXCL8
41 ischemia 10.2
42 hypoxia 10.2
43 retinitis pigmentosa 55 10.2 IL6 TNF
44 critical limb ischemia 10.2 IL6 TNF
45 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
46 juvenile ankylosing spondylitis 10.2 IL6 TNF
47 pericoronitis 10.2 CRP IL1B
48 schnitzler syndrome 10.2 CRP IL1B
49 null-cell leukemia 10.2 IL6 TNF
50 anca-associated vasculitis 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to Perinatal Necrotizing Enterocolitis
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Symptoms & Phenotypes for Perinatal Necrotizing Enterocolitis

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MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 CRP EGF IL1B IL6 LY96 PLA2G7
Sources

Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

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Drugs for Perinatal Necrotizing Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 326)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
2
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-83-0 5994
3
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
4
Caffeine Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-08-2 2519
5 Poractant alfa Approved Phase 4,Not Applicable 129069-19-8
6
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53-86-1 3715
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 1177-87-3
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-02-2 5743
9
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
11
Iodine Approved, Investigational Phase 4 7553-56-2 807
12
Zinc Approved, Investigational Phase 4 7440-66-6
13
Nifedipine Approved Phase 4,Phase 3,Not Applicable 21829-25-4 4485
14
Labetalol Approved Phase 4,Phase 2,Phase 3 36894-69-6 3869
15
Methyldopa Approved Phase 4 555-30-6 38853
16
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
17
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 77-92-9 311
18
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
19
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 1406-16-2
20
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 5280795 6221
21
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
22
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
23 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2,Not Applicable
25 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2,Not Applicable
26 Betamethasone Valerate Phase 4,Phase 3,Phase 2,Not Applicable 2152-44-5
27 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Betamethasone benzoate Phase 4,Phase 3,Phase 2,Not Applicable
32 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Acidophilus Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
37 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Caffeine citrate Phase 4,Phase 3,Phase 2,Not Applicable
44 Citrate Phase 4,Phase 3,Phase 2,Not Applicable
45 Purinergic P1 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
46 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
47 Anticoagulants Phase 4,Phase 3,Phase 2,Not Applicable
48 Chelating Agents Phase 4,Phase 3,Phase 2,Not Applicable
49 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Central Nervous System Stimulants Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 485)
# Name Status NCT ID Phase Drugs
1 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
2 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
3 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
4 Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
5 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
6 Comparison of Lactobacillus Reuteri and Nystatin Prophylaxis on Candida Colonization and Infection in Very Low Birth Weight Infants Completed NCT01531192 Phase 4 Nystatin
7 A Randomised Controlled Trial of Iodide Supplementation in Preterm Infants Follow-up at 2 Years Completed NCT00638092 Phase 4 sodium iodide;Sodium Chloride
8 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
9 Ibuprofen and Renal Function in Premature Infants Completed NCT00217191 Phase 4 Ibuprofen
10 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT01515696 Phase 4 Gastrografin;Sterile water
11 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
12 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
13 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
14 Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies Completed NCT01695070 Phase 4 Melatonin
15 The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
16 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
17 Vaginal Progesterone for the Prolongation of Pregnancy After Arrested Pre-term Labor Recruiting NCT02430233 Phase 4 micronized progesterone 400 mg (Utrogestan)
18 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
19 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
20 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
21 Rate of Bronchopulmonary Dysplasia in Preterms Neonates: a Trial Comparing SMOFlipid and Medialipide Not yet recruiting NCT02853253 Phase 4
22 Sodium Supplementation and Growth in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4 Sodium chloride;Placebo
23 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
24 Pilot Study to Compare Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Withdrawn NCT02774317 Phase 4
25 RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section Withdrawn NCT02009098 Phase 4 Cefuroxime
26 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
27 Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3 Saccharomyces boulardii;Placebo
28 Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth Unknown status NCT00735137 Phase 3
29 Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane Unknown status NCT01503606 Phase 3 Cefazolin;Clarithromycin;Cefazolin;Clarithromycin
30 Clarithromycin Prophylaxis in Preterm Infants Colonisation With Ureaplasma Urealyticum and Mycoplasma Hominis Unknown status NCT01652118 Phase 3 clarithromycin treatment for prophylaxis of bronchopulmonary dysplasia;Saline
31 Prophylactic Acetaminophen for Prevention Intraventricular Hemorrhage in Premature Infants Unknown status NCT03024814 Phase 3 Acetaminophen;Dextrose 5
32 Cysteine Supplementation in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
33 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Unknown status NCT02678026 Phase 3
34 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
35 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
36 Modulation of the Intestinal Flora With the Probiotic VIVOMIXXâ„¢ in Pregnant Women at Risk of Metabolic Complications Unknown status NCT02768818 Phase 3
37 Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants Completed NCT01531179 Phase 3 Lactobacillus reuteri;Placebo
38 Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants Completed NCT01868737 Phase 3
39 Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants Completed NCT01340469 Phase 3
40 The Efficacy of Symbiotic on Cytokines Completed NCT01899677 Phase 3 symbiotic
41 Role of Probiotics for Prevention of NEC in Preterm VLBW Infants Completed NCT02650869 Phase 3
42 Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis Completed NCT00707785 Phase 3
43 A Single Blinded Study on the Effect of Saccharomyces Boulardii CNCM I-745 on Growth and Development in Preterm Infants Completed NCT02310425 Phase 3 S. boulardii;Placebo
44 Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth Completed NCT02350231 Phase 2, Phase 3 The progesterone vaginal pessary;Tonics group
45 Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSF Completed NCT00213759 Phase 3 filgrastim;dextrose 5%
46 Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis Completed NCT02954926 Phase 3 IVIG
47 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
48 Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia Completed NCT02059135 Phase 3
49 Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled Study Completed NCT01266928 Phase 3 vitamine C and E
50 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Cochrane evidence based reviews: enterocolitis, necrotizing

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Genetic Tests for Perinatal Necrotizing Enterocolitis

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Anatomical Context for Perinatal Necrotizing Enterocolitis

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MalaCards organs/tissues related to Perinatal Necrotizing Enterocolitis:

41
Heart, Colon, Liver, Brain, Neutrophil, Lung, Bone
Sources

Publications for Perinatal Necrotizing Enterocolitis

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Articles related to Perinatal Necrotizing Enterocolitis:

(show top 50) (show all 1223)
# Title Authors Year
1
Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia. ( 30527488 )
2019
2
Role of delayed cord clamping in prevention of necrotizing enterocolitis in preterm neonates: a systematic review. ( 28826265 )
2019
3
New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment. ( 29980346 )
2018
4
Necrotizing enterocolitis in the setting of milk allergy after pediatric living donor liver transplantation. ( 29218832 )
2018
5
Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet. ( 29877722 )
2018
6
Necrotizing enterocolitis as a prognostic factor for the neurodevelopmental outcome of preterm infants - match control study after 2years. ( 29409620 )
2018
7
Necrotizing Enterocolitis Cases Associated with Nosocomial Enterovirus Transmission in a Neonatal Unit. ( 29389824 )
2018
8
Increased incidence of necrotizing enterocolitis associated with routine administration of Inflorana8c in extremely preterm infants. ( 29888655 )
2018
9
Characteristics and incidence of transfusion-associated necrotizing enterocolitis in the UKCharacteristics and incidence of transfusion-associated necrotizing enterocolitis in the UK. ( 29945481 )
2018
10
Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC). ( 29930978 )
2018
11
Nutrition Management of Necrotizing Enterocolitis. ( 29940075 )
2018
12
Candidate gene analysis in pathogenesis of surgically and non-surgically treated necrotizing enterocolitis in preterm infants. ( 28770467 )
2018
13
Routine Supplementation of Lactobacillus rhamnosus GG and Risk of Necrotizing Enterocolitis in Very Low Birth Weight Infants. ( 29402455 )
2018
14
Rho Kinase Inhibition Maintains Intestinal and Vascular Barrier Function by Upregulation of Occludin in Experimental Necrotizing Enterocolitis. ( 29927318 )
2018
15
Technical aspects of abdominal ultrasound and color Doppler assessment of bowel viability in necrotizing enterocolitis. ( 29368011 )
2018
16
Necrotizing enterocolitis is associated with acute brain responses in preterm pigs. ( 29885660 )
2018
17
The Microbiome and Metabolome of Preterm Infant Stool Are Personalized and Not Driven by Health Outcomes, Including Necrotizing Enterocolitis and Late-Onset Sepsis. ( 29875143 )
2018
18
Lactobacillus murinus HF12 colonizes neonatal gut and protects rats from necrotizing enterocolitis. ( 29933378 )
2018
19
Preterm infant gut microbial patterns related to the development of necrotizing enterocolitis. ( 29909714 )
2018
20
Clostridial strain-specific characteristics associated with necrotizing enterocolitis. ( 29352082 )
2018
21
TNF-I+ induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing enterocolitis model cells IEC-6. ( 29950141 )
2018
22
Necrotizing Enterocolitis in Infants with Hypoplastic Left Heart Syndrome Following Stage 1 Palliation or Heart Transplant. ( 29392349 )
2018
23
Topiramate for Seizures in Preterm Infants and the Development of Necrotizing Enterocolitis. ( 29903834 )
2018
24
[Intrauterine necrotizing enterocolitis in premature newborns]. ( 29393025 )
2018
25
Reply to: Letter to the Editor by Stritzke A and Shah PS. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis. ( 29883324 )
2018
26
Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis. ( 29351876 )
2018
27
Bowel Ultrasound for the Diagnosis of Necrotizing Enterocolitis: A Meta-analysis. ( 29369246 )
2018
28
Expert consensus to weight an adherence score for audit and feedback of practices that prevent necrotizing enterocolitis in very low birth weight infants. ( 29422156 )
2018
29
Preterm infants undergoing laparotomy for necrotizing enterocolitis or spontaneous intestinal perforation display evidence of impaired cerebrovascular autoregulation. ( 29454185 )
2018
30
Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis. ( 29360809 )
2018
31
Necrotizing Enterocolitis in Two Siblings and an Unrelated Infant with Overlapping Chromosome 6q25 Deletions. ( 29928179 )
2018
32
Clostridium neonatale sp. nov. linked to necrotizing enterocolitis in neonates and a clarification of species assignable to the genus Clostridium (Prazmowski 1880) emend. Lawson and Rainey 2016. ( 29889020 )
2018
33
Significance of dynamic evolution of TNF-I+, IL-6 and intestinal fatty acid-binding protein levels in neonatal necrotizing enterocolitis. ( 29399120 )
2018
34
Necrotizing enterocolitis and appendicitis in preterm infants. ( 30048607 )
2018
35
Intestinal failure associated cholestasis in surgical necrotizing enterocolitis and spontaneous intestinal perforation. ( 30413273 )
2018
36
Clinical characteristic comparison of low birth weight and very low birth weight preterm infants with neonatal necrotizing enterocolitis: a single tertiary center experience from eastern China. ( 30128701 )
2018
37
Neonatal intestinal dysbiosis in necrotizing enterocolitis. ( 30134786 )
2018
38
Targeted LC-MS/MS for the evaluation of proteomics biomarkers in the blood of neonates with necrotizing enterocolitis and late-onset sepsis. ( 30141021 )
2018
39
Enteral feeding composition and necrotizing enterocolitis. ( 30143341 )
2018
40
Necrotizing Enterocolitis and Neurodevelopmental Outcome. ( 30144849 )
2018
41
The cost of necrotizing enterocolitis in premature infants. ( 30145059 )
2018
42
Neurodevelopmental outcomes following necrotizing enterocolitis. ( 30145060 )
2018
43
Innate and adaptive immunity in necrotizing enterocolitis. ( 30146477 )
2018
44
Retrospective case-control study of necrotizing enterocolitis and packed red blood cell transfusions in very low birth weight infants. ( 30149467 )
2018
45
Prophylactic lactoferrin for preventing late-onset sepsis and necrotizing enterocolitis in preterm infants: A PRISMA-compliant systematic review and meta-analysis. ( 30170397 )
2018
46
Necrotizing enterocolitis: The intestinal microbiome, metabolome and inflammatory mediators. ( 30172660 )
2018
47
Surgical considerations for neonates with necrotizing enterocolitis. ( 30196017 )
2018
48
Interleukin-6 serum levels predict surgical intervention in infants with necrotizing enterocolitis. ( 30213531 )
2018
49
Intestinal microcirculation and necrotizing enterocolitis: The vascular endothelial growth factor system. ( 30213591 )
2018
50
Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. ( 30236604 )
2018
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Variations for Perinatal Necrotizing Enterocolitis

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Expression for Perinatal Necrotizing Enterocolitis

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Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.
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Pathways for Perinatal Necrotizing Enterocolitis

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Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.02 CRP CXCL8 EGF HBEGF IL1B IL6
2
Akt Signaling 64
Show member pathways
 13.42 CXCL8 EGF IL1B IL6 THPO TLR4
3
PAK Pathway 64
Show member pathways
 13.3 CXCL8 EGF HBEGF IL1B IL6 PLA2G7
4
IL-2 Pathway 64
Show member pathways
 13.19 EGF HBEGF IL1B TLR4 TLR9 TNF
5
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.96 CXCL8 IL1B IL6 LY96 SIGIRR TLR4
6
Influenza A 37
Show member pathways
 12.82 CXCL8 IL1B IL6 TLR4 TLR9 TNF
7
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.78 CXCL8 IL1B IL6 LY96 TLR4 TNF
8
TRAF Pathway 64
Show member pathways
 12.64 IL1B LY96 SIGIRR TLR4 TLR9 TNF
9
NF-KappaB Family Pathway 64
Show member pathways
 12.64 EGF IL1B IL6 THPO TLR4 TLR9
10
Th17 cell differentiation 37
Show member pathways
 12.57 IL1B IL6 TLR4 TNF
11
VEGF Pathway (Qiagen) 22
Show member pathways
 12.45 EGF LY96 SIGIRR TLR4 TLR9
12
Selenium Micronutrient Network 1
Show member pathways
 12.35 CRP IL1B IL6 TNF
13
IL-17 Family Signaling Pathways 65
Show member pathways
 12.35 CXCL8 IL1B IL6 TNF
14
Toll Comparative Pathway 64
Show member pathways
 12.32 CXCL8 IL1B IL6 LY96 TLR4 TNF
15
Toxoplasmosis 37
Show member pathways
 12.28 IL1B LY96 TLR4 TNF
16
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.28 CXCL8 HBEGF IL1B IL6 THPO TNF
17
Tuberculosis 37
12.27 IL1B IL6 TLR4 TLR9 TNF
18
IL-1 Family Signaling Pathways 65
Show member pathways
 12.25 CXCL8 IL1B IL6 SIGIRR TNF
19
C-type lectin receptor signaling pathway 37
Show member pathways
 12.24 IL1B IL6 TLR9 TNF
20
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.21 CXCL8 IL1B IL6 TNF
21
Colorectal Cancer Metastasis 64
12.21 EGF IL6 TLR4 TLR9 TNF
22
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.16 CXCL8 IL6 LY96 TLR4 TLR9 TNF
23
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.1 CXCL8 EGF IL1B IL6 THPO
24
Th1 Differentiation Pathway 65
Show member pathways
 12.09 IL1B IL6 TLR4 TLR9 TNF
25
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.07 IL1B IL6 LY96 TLR4 TNF
26
Interleukin-4 and 13 signaling 66
12.03 CXCL8 IL1B IL6 TNF
27
Spinal Cord Injury 1
12.03 CXCL8 IL1B IL6 TLR4 TNF
28
MAPK Pathway 72
Show member pathways
 12.01 IL1B TLR4 TLR9
29
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.97 IL6 THPO TNF
30
AGE-RAGE signaling pathway in diabetic complications 37
11.96 CXCL8 IL1B IL6 TNF
31
TNF signaling pathway 37
11.95 IL1B IL6 TNF
32
Hematopoietic cell lineage 37
11.94 IL1B IL6 THPO TNF
33
Senescence and Autophagy in Cancer 1
11.93 CXCL8 IL1B IL6
34
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.92 CXCL8 IL6 LY96 TLR4
35
HIF-1 signaling pathway 37
11.9 EGF IL6 TLR4
36
Salmonella infection (KEGG) 37
11.87 CXCL8 IL1B IL6 TLR4
37
Amoebiasis 37
11.87 CXCL8 IL1B IL6 TLR4 TNF
38
NF-kappa B signaling pathway 37
11.83 CXCL8 IL1B LY96 TLR4 TNF
39
Dendritic Cells Developmental Lineage Pathway 65
11.79 IL1B IL6 TLR9 TNF
40
Rheumatoid arthritis 37
11.79 CXCL8 IL1B IL6 TLR4 TNF
41
Bladder cancer 37 1
11.76 CXCL8 EGF HBEGF
42
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.75 IL1B IL6 TNF
43
NF-kB (NFkB) Pathway 67
11.75 LY96 TLR4 TNF
44
Bacterial infections in CF airways 22
Show member pathways
 11.72 CXCL8 IL1B IL6 LY96 TLR4 TLR9
45
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.71 CXCL8 IL1B IL6 TNF
46
LPA receptor mediated events 1
11.7 CXCL8 HBEGF IL6
47
Transcription_NF-kB signaling pathway 22
11.62 LY96 TLR4 TNF
48
Photodynamic therapy-induced AP-1 survival signaling. 1
11.59 HBEGF IL6 TNF
49
Interleukin-10 signaling 66
11.58 CXCL8 IL1B IL6 TNF
50
MSP-RON Signaling 64
11.56 IL1B TLR4 TNF
Sources

GO Terms for Perinatal Necrotizing Enterocolitis

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Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 CRP CXCL8 EGF HBEGF IL1B IL6
2 extracellular region GO:0005576 9.36 CRP CXCL8 EGF HBEGF IL1B IL6
3 lipopolysaccharide receptor complex GO:0046696 9.16 LY96 TLR4

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.99 EGF HBEGF IL1B TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 IL1B TLR4 TLR9 TNF
3 positive regulation of protein kinase B signaling GO:0051897 9.96 EGF HBEGF THPO TNF
4 positive regulation of gene expression GO:0010628 9.91 CRP EGF IL1B IL6 TLR4 TLR9
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.9 IL1B IL6 TNF
6 activation of MAPK activity GO:0000187 9.9 EGF IL1B TLR4 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.89 CRP IL6 TNF
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.88 EGF HBEGF IL6
9 defense response to Gram-negative bacterium GO:0050829 9.88 IL6 TLR4 TLR9
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B IL6 TLR4 TLR9 TNF
11 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TLR9 TNF
12 response to glucocorticoid GO:0051384 9.86 IL1B IL6 TNF
13 apoptotic signaling pathway GO:0097190 9.85 LY96 TLR4 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 HBEGF IL6 TNF
15 positive regulation of tumor necrosis factor production GO:0032760 9.85 LY96 TLR4 TLR9
16 positive regulation of inflammatory response GO:0050729 9.85 PLA2G7 TLR4 TLR9 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.83 IL1B TLR4 TNF
18 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.83 LY96 TLR4 TLR9 TNF
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B TLR4 TNF
20 positive regulation of JUN kinase activity GO:0043507 9.81 IL1B TLR9 TNF
21 toll-like receptor signaling pathway GO:0002224 9.8 LY96 TLR4 TLR9
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 IL1B TLR4 TLR9 TNF
23 acute-phase response GO:0006953 9.79 CRP IL6 SIGIRR
24 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.78 LY96 TLR4 TLR9
25 negative regulation of interleukin-6 production GO:0032715 9.77 TLR4 TLR9 TNF
26 negative regulation of neurogenesis GO:0050768 9.76 IL1B IL6 TNF
27 embryonic digestive tract development GO:0048566 9.73 CXCL8 TNF
28 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
29 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
30 toll-like receptor 4 signaling pathway GO:0034142 9.73 LY96 TLR4
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.72 TLR4 TLR9
34 regulation of cytokine secretion GO:0050707 9.72 TLR4 TLR9
35 I-kappaB phosphorylation GO:0007252 9.71 TLR4 TLR9
36 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 TLR9
37 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.71 LY96 TLR4
38 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B IL6 TNF
39 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 IL1B LY96 TLR4 TNF
40 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.7 IL1B TLR9
41 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
42 positive regulation of interferon-beta biosynthetic process GO:0045359 9.69 TLR4 TLR9
43 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TLR9 TNF
44 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.68 LY96 TLR4
45 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
46 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
47 chronic inflammatory response to antigenic stimulus GO:0002439 9.65 IL1B TNF
48 detection of lipopolysaccharide GO:0032497 9.65 LY96 TLR4
49 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
50 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.26 IL1B TLR9
2 growth factor activity GO:0008083 9.26 EGF HBEGF IL6 THPO
3 lipopolysaccharide receptor activity GO:0001875 9.16 LY96 TLR4
4 cytokine activity GO:0005125 9.02 CXCL8 IL1B IL6 THPO TNF
Sources

Sources for Perinatal Necrotizing Enterocolitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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