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MCID: PRN019
MIFTS: 56

Perinatal Necrotizing Enterocolitis

Categories: Rare diseases, Fetal diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Perinatal Necrotizing Enterocolitis

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MalaCards integrated aliases for Perinatal Necrotizing Enterocolitis:

Name: Perinatal Necrotizing Enterocolitis 12 15
Necrotizing Enterocolitis 12 53 59 73
Enterocolitis, Necrotizing 53 44
Enterocolitis Necrotizing 12 55
Necrotizing Enterocolitis in Fetus or Newborn 12
Pseudomembranous Enterocolitis in Newborn 12
Perinatal Necrotising Enterocolitis 12
Nec 53

Characteristics:

Orphanet epidemiological data:

59
necrotizing enterocolitis
Prevalence: 1-5/10000 (Worldwide); Age of onset: Neonatal; Age of death: infantile;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34 33


External Ids:

Disease Ontology 12 DOID:8677
MeSH 44 D020345
NCIt 50 C84915
Orphanet 59 ORPHA391673
ICD10 via Orphanet 34 P77
UMLS via Orphanet 74 C0520459
ICD10 33 P77
UMLS 73 C0520459
Sources

Summaries for Perinatal Necrotizing Enterocolitis

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NIH Rare Diseases : 53 Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.

MalaCards based summary : Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to short bowel syndrome and neuroendocrine carcinoma of pancreas. An important gene associated with Perinatal Necrotizing Enterocolitis is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Progesterone and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and cervix, and related phenotypes are digestive/alimentary and immune system

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Related Diseases for Perinatal Necrotizing Enterocolitis

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Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
# Related Disease Score Top Affiliating Genes
1 short bowel syndrome 11.4
2 neuroendocrine carcinoma of pancreas 10.9
3 eye lymphoma 10.6 IL6 TLR9
4 cervical incompetence 10.5 IL6 SERPINH1
5 prosthetic joint infection 10.5 IL1B TLR4
6 pouchitis 10.5 CXCL8 TLR4
7 acute transverse myelitis 10.4 CXCL8 IL6
8 enterocolitis 10.3
9 periodontitis, chronic 10.3 IL1B IL6
10 invasive aspergillosis 10.3 CXCL8 TLR4 TLR9
11 cold agglutinin disease 10.3 CRP IL6
12 denture stomatitis 10.3 CXCL8 IL6
13 papillary conjunctivitis 10.2 CXCL8 IL6
14 keratitis, hereditary 10.2 IL1B TLR4 TLR9
15 cryopyrin-associated periodic syndrome 10.2 CRP IL6
16 bacteriuria 10.2 CXCL8 IL6 TLR4
17 folic acid deficiency anemia 10.2 CRP THPO
18 cardiogenic shock 10.2 CRP IL6
19 acute cholangitis 10.2 CRP IL6
20 preterm premature rupture of the membranes 10.1 CXCL8 IL6 SERPINH1
21 neutrophilia, hereditary 10.1 CRP IL6
22 slow-channel congenital myasthenic syndrome 10.1 CRP CXCL8
23 peptic esophagitis 10.1 CXCL8 IL1B
24 cysticercosis 10.1 IL1B IL6 TLR4
25 pyuria 10.1 CRP CXCL8
26 spondylarthropathy 10.1 TLR4 TNF
27 gastric ulcer 10.1 CXCL8 EGF IL1B
28 trench fever 10.1 TLR4 TNF
29 dental abscess 10.1 CRP TLR4
30 scorpion envenomation 10.1 IL6 TNF
31 stomach disease 10.1 CXCL8 IL1B TLR9
32 mesenteric lymphadenitis 10.0 CRP EGF IL6
33 bladder disease 10.0 CRP HBEGF IL6
34 viral pneumonia 10.0 CRP IL6 TLR9
35 adult dermatomyositis 10.0 TLR9 TNF
36 leukomalacia 10.0 IL6 TNF
37 angioimmunoblastic lymphadenopathy with dysproteinemia 10.0 IL6 TNF
38 interstitial cystitis 10.0 CXCL8 EGF HBEGF IL6
39 recurrent corneal erosion 10.0 CXCL8 IL1B IL6
40 bagassosis 10.0 CXCL8 IL1B IL6
41 glossitis 10.0 IL1B IL6
42 critical limb ischemia 10.0 IL6 TNF
43 iron deficiency anemia 10.0 CRP IL6 THPO
44 thrombocytosis 9.9 CRP IL6 THPO
45 coronary stenosis 9.9 CRP IL6 TLR4
46 null-cell leukemia 9.9 IL6 TNF
47 tungiasis 9.9 CXCL8 TNF
48 spinal disease 9.9 CRP IL6
49 septic arthritis 9.9 CRP CXCL8 TLR4
50 extrinsic allergic alveolitis 9.9 CXCL8 IL1B IL6

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to Perinatal Necrotizing Enterocolitis
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Symptoms & Phenotypes for Perinatal Necrotizing Enterocolitis

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MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 TNF EGF IL6 SERPINH1 SIGIRR TLR4
2 immune system MP:0005387 9.32 CRP EGF IL1B IL6 PLA2G7 SIGIRR
Sources

Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

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Drugs for Perinatal Necrotizing Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 297)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-83-0 5994
2
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
3
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
4
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53-86-1 3715
5 Poractant alfa Approved Phase 4,Not Applicable 129069-19-8
6
Zinc Approved, Investigational Phase 4 7440-66-6 23994
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
8
Iodine Approved, Investigational Phase 4 7553-56-2 807
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-02-2 5743
10
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
11
Labetalol Approved Phase 4,Phase 2,Phase 3 36894-69-6 3869
12
Nifedipine Approved Phase 4,Phase 3 21829-25-4 4485
13
Methyldopa Approved Phase 4 555-30-6 38853
14
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 77-92-9 311
15
Caffeine Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 58-08-2 2519
16
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 1406-16-2
17
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
18
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 6221 5280795
19
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
20
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
21
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
22 Betamethasone Valerate Phase 4,Phase 3,Phase 2,Not Applicable 2152-44-5
23 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 calcium channel blockers Phase 4,Phase 3,Phase 2
25 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
26 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
28 Central Nervous System Stimulants Phase 4,Phase 3,Phase 2,Not Applicable
29 Chelating Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Tocolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
43 Anticoagulants Phase 4,Phase 3,Phase 2,Not Applicable
44 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Pulmonary Surfactants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Purinergic P1 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
50 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 448)
# Name Status NCT ID Phase Drugs
1 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
2 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
3 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
4 Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
5 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
6 Comparison of Lactobacillus Reuteri and Nystatin Prophylaxis on Candida Colonization and Infection in Very Low Birth Weight Infants Completed NCT01531192 Phase 4 Nystatin
7 A Randomised Controlled Trial of Iodide Supplementation in Preterm Infants Follow-up at 2 Years Completed NCT00638092 Phase 4 sodium iodide;Sodium Chloride
8 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
9 Ibuprofen and Renal Function in Premature Infants Completed NCT00217191 Phase 4 Ibuprofen
10 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT01515696 Phase 4 Gastrografin;Sterile water
11 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
12 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
13 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
14 Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies Completed NCT01695070 Phase 4 Melatonin
15 The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
16 Pilot Study to Compare Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Recruiting NCT02774317 Phase 4
17 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
18 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
19 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
20 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
21 Rate of Bronchopulmonary Dysplasia in Preterms Neonates: a Trial Comparing SMOFlipid and Medialipide Not yet recruiting NCT02853253 Phase 4
22 Sodium Supplementation and Growth in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4 Sodium chloride;Placebo
23 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
24 RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section Withdrawn NCT02009098 Phase 4 Cefuroxime
25 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
26 Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3 Saccharomyces boulardii;Placebo
27 Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth Unknown status NCT00735137 Phase 3
28 Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane Unknown status NCT01503606 Phase 3 Cefazolin;Clarithromycin;Cefazolin;Clarithromycin
29 Clarithromycin Prophylaxis in Preterm Infants Colonisation With Ureaplasma Urealyticum and Mycoplasma Hominis Unknown status NCT01652118 Phase 3 clarithromycin treatment for prophylaxis of bronchopulmonary dysplasia;Saline
30 Cysteine Supplementation in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
31 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Unknown status NCT02678026 Phase 3
32 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
33 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
34 Modulation of the Intestinal Flora With the Probiotic VIVOMIXXâ„¢ in Pregnant Women at Risk of Metabolic Complications Unknown status NCT02768818 Phase 3
35 Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants Completed NCT01531179 Phase 3 Lactobacillus reuteri;Placebo
36 Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants Completed NCT01868737 Phase 3
37 Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants Completed NCT01340469 Phase 3
38 The Efficacy of Symbiotic on Cytokines Completed NCT01899677 Phase 3 symbiotic
39 Role of Probiotics for Prevention of NEC in Preterm VLBW Infants Completed NCT02650869 Phase 3
40 Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis Completed NCT00707785 Phase 3
41 A Single Blinded Study on the Effect of Saccharomyces Boulardii CNCM I-745 on Growth and Development in Preterm Infants Completed NCT02310425 Phase 3 S. boulardii;Placebo
42 Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth Completed NCT02350231 Phase 2, Phase 3 The progesterone vaginal pessary;Tonics group
43 Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSF Completed NCT00213759 Phase 3 filgrastim;dextrose 5%
44 Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis Completed NCT02954926 Phase 3 IVIG
45 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
46 Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia Completed NCT02059135 Phase 3
47 Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled Study Completed NCT01266928 Phase 3 vitamine C and E
48 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
49 Probiotics-Supplemented Feeding in Extremely Low Birth Weight Infants Completed NCT01164124 Phase 2, Phase 3
50 Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) Completed NCT00009646 Phase 3 indomethacin;Indomethacin;Placebo

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Cochrane evidence based reviews: enterocolitis, necrotizing

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Genetic Tests for Perinatal Necrotizing Enterocolitis

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Anatomical Context for Perinatal Necrotizing Enterocolitis

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MalaCards organs/tissues related to Perinatal Necrotizing Enterocolitis:

41
Heart, Colon, Cervix, Brain, Lung, Neutrophil, T Cells
Sources

Publications for Perinatal Necrotizing Enterocolitis

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Articles related to Perinatal Necrotizing Enterocolitis:

(show top 50) (show all 407)
# Title Authors Year
1
New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment. ( 29980346 )
2018
2
Necrotizing enterocolitis in the setting of milk allergy after pediatric living donor liver transplantation. ( 29218832 )
2018
3
Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet. ( 29877722 )
2018
4
Necrotizing enterocolitis as a prognostic factor for the neurodevelopmental outcome of preterm infants - match control study after 2years. ( 29409620 )
2018
5
Necrotizing Enterocolitis Cases Associated with Nosocomial Enterovirus Transmission in a Neonatal Unit. ( 29389824 )
2018
6
Increased incidence of necrotizing enterocolitis associated with routine administration of Inflorana8c in extremely preterm infants. ( 29888655 )
2018
7
Characteristics and incidence of transfusion-associated necrotizing enterocolitis in the UKCharacteristics and incidence of transfusion-associated necrotizing enterocolitis in the UK. ( 29945481 )
2018
8
Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC). ( 29930978 )
2018
9
Nutrition Management of Necrotizing Enterocolitis. ( 29940075 )
2018
10
Candidate gene analysis in pathogenesis of surgically and non-surgically treated necrotizing enterocolitis in preterm infants. ( 28770467 )
2018
11
Routine Supplementation of Lactobacillus rhamnosus GG and Risk of Necrotizing Enterocolitis in Very Low Birth Weight Infants. ( 29402455 )
2018
12
Rho Kinase Inhibition Maintains Intestinal and Vascular Barrier Function by Upregulation of Occludin in Experimental Necrotizing Enterocolitis. ( 29927318 )
2018
13
Technical aspects of abdominal ultrasound and color Doppler assessment of bowel viability in necrotizing enterocolitis. ( 29368011 )
2018
14
Necrotizing enterocolitis is associated with acute brain responses in preterm pigs. ( 29885660 )
2018
15
The Microbiome and Metabolome of Preterm Infant Stool Are Personalized and Not Driven by Health Outcomes, Including Necrotizing Enterocolitis and Late-Onset Sepsis. ( 29875143 )
2018
16
Lactobacillus murinus HF12 colonizes neonatal gut and protects rats from necrotizing enterocolitis. ( 29933378 )
2018
17
Preterm infant gut microbial patterns related to the development of necrotizing enterocolitis. ( 29909714 )
2018
18
Clostridial strain-specific characteristics associated with necrotizing enterocolitis. ( 29352082 )
2018
19
TNF-I+ induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing enterocolitis model cells IEC-6. ( 29950141 )
2018
20
Necrotizing Enterocolitis in Infants with Hypoplastic Left Heart Syndrome Following Stage 1 Palliation or Heart Transplant. ( 29392349 )
2018
21
Topiramate for Seizures in Preterm Infants and the Development of Necrotizing Enterocolitis. ( 29903834 )
2018
22
[Intrauterine necrotizing enterocolitis in premature newborns]. ( 29393025 )
2018
23
Reply to: Letter to the Editor by Stritzke A and Shah PS. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis. ( 29883324 )
2018
24
Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis. ( 29351876 )
2018
25
Bowel Ultrasound for the Diagnosis of Necrotizing Enterocolitis: A Meta-analysis. ( 29369246 )
2018
26
Expert consensus to weight an adherence score for audit and feedback of practices that prevent necrotizing enterocolitis in very low birth weight infants. ( 29422156 )
2018
27
Preterm infants undergoing laparotomy for necrotizing enterocolitis or spontaneous intestinal perforation display evidence of impaired cerebrovascular autoregulation. ( 29454185 )
2018
28
Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis. ( 29360809 )
2018
29
Necrotizing Enterocolitis in Two Siblings and an Unrelated Infant with Overlapping Chromosome 6q25 Deletions. ( 29928179 )
2018
30
Clostridium neonatale sp. nov. linked to necrotizing enterocolitis in neonates and a clarification of species assignable to the genus Clostridium (Prazmowski 1880) emend. Lawson and Rainey 2016. ( 29889020 )
2018
31
Significance of dynamic evolution of TNF-I+, IL-6 and intestinal fatty acid-binding protein levels in neonatal necrotizing enterocolitis. ( 29399120 )
2018
32
Risk factors for necrotizing enterocolitis in very preterm infants: a case-control study in southwest China. ( 29096567 )
2017
33
Independence of gut bacterial content and neonatal necrotizing enterocolitis severity. ( 28410788 )
2017
34
High prevalence of cytomegalovirus infection in surgical intestinal specimens from infants with necrotizing enterocolitis and spontaneous intestinal perforation: A retrospective observational study. ( 28633098 )
2017
35
Enzymatic and Chemoenzymatic Syntheses of Disialyl Glycans and Their Necrotizing Enterocolitis Preventing Effects. ( 29124935 )
2017
36
Diagnostic imaging features of necrotizing enterocolitis: a narrative review. ( 28812000 )
2017
37
Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis. ( 29068791 )
2017
38
Association of single nucleotide polymorphisms of IL23R and IL17 with necrotizing enterocolitis in premature infants. ( 28224332 )
2017
39
Development of a Gestational Age-Specific Case Definition for Neonatal Necrotizing Enterocolitis. ( 28046187 )
2017
40
Multiple strains probiotics appear to be the most effective probiotics in the prevention of necrotizing enterocolitis and mortality: An updated meta-analysis. ( 28182644 )
2017
41
Serum Markers of Necrotizing Enterocolitis: A Systematic Review. ( 28379923 )
2017
42
Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis From Spontaneous Intestinal Perforation. ( 27745748 )
2017
43
A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants. ( 27893720 )
2017
44
Predictive and diagnostic value of serum intestinal fatty acid binding protein in neonatal necrotizing enterocolitis (case series). ( 28761640 )
2017
45
Insulin-like growth factor I reduces the occurrence of necrotizing enterocolitis by reducing inflammatory response and protecting intestinal mucosal barrier in neonatal rats model. ( 29131241 )
2017
46
Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis. ( 28774871 )
2017
47
Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies. ( 28410573 )
2017
48
NEC-zero recommendations from scoping review of evidence to prevent and foster timely recognition of necrotizing enterocolitis. ( 29270303 )
2017
49
Necrotizing Enterocolitis and Growth in Preterm Infants Fed Predominantly Maternal Milk, Pasteurized Donor Milk, or Preterm Formula: A Retrospective Study. ( 27936476 )
2017
50
Severe hemolysis after plasma transfusion in a neonate with necrotizing enterocolitis, Clostridium perfringens infection, and red blood cell T-polyagglutination. ( 28643465 )
2017
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Variations for Perinatal Necrotizing Enterocolitis

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Expression for Perinatal Necrotizing Enterocolitis

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Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.
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Pathways for Perinatal Necrotizing Enterocolitis

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Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14 CRP CXCL8 EGF HBEGF IL1B IL6
2
Akt Signaling 64
Show member pathways
 13.39 CXCL8 EGF IL1B IL6 THPO TLR4
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.31 CXCL8 EGF HBEGF IL1B IL6 TNF
4
PAK Pathway 64
Show member pathways
 13.28 CXCL8 EGF HBEGF IL1B IL6 PLA2G7
5
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13 CXCL8 IL1B IL6 SIGIRR TLR4 TLR9
6
Influenza A 37
Show member pathways
 12.79 CXCL8 IL1B IL6 TLR4 TLR9 TNF
7
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.75 CXCL8 IL1B IL6 TLR4 TNF
8
Regulation of IFNA signaling 66
Show member pathways
 12.6 CXCL8 EGF IL1B IL6 THPO TNF
9
NF-KappaB Family Pathway 64
Show member pathways
 12.59 EGF IL1B IL6 THPO TLR4 TLR9
10
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.54 CXCL8 IL6 TLR4 TNF
11
TRAF Pathway 64
Show member pathways
 12.51 IL1B TLR4 TLR9 TNF
12
Th17 cell differentiation 37
Show member pathways
 12.43 IL1B IL6 TLR4 TNF
13
VEGF Pathway (Qiagen) 64
Show member pathways
 12.38 EGF SIGIRR TLR4 TLR9
14
Folate Metabolism 1
Show member pathways
 12.33 CRP IL1B IL6 TNF
15
IL-17 Family Signaling Pathways 65
Show member pathways
 12.33 CXCL8 IL1B IL6 TNF
16
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.28 CXCL8 IL6 TLR4 TLR9 TNF
17
Th1 Differentiation Pathway 65
Show member pathways
 12.26 IL1B IL6 TLR4 TLR9 TNF
18
Toll Comparative Pathway 64
Show member pathways
 12.25 CXCL8 IL1B IL6 TLR4 TNF
19
Tuberculosis 37
12.23 IL1B IL6 TLR4 TLR9 TNF
20
C-type lectin receptor signaling pathway 37
Show member pathways
 12.22 IL1B IL6 TLR9 TNF
21
IL-1 Family Signaling Pathways 65
Show member pathways
 12.21 CXCL8 IL1B IL6 SIGIRR TNF
22
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.19 CXCL8 IL1B IL6 TNF
23
Colorectal Cancer Metastasis 64
12.16 EGF IL6 TLR4 TLR9 TNF
24
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.08 CXCL8 EGF IL1B IL6 THPO
25
Hepatitis C 37
12.02 CXCL8 EGF TNF
26
Interleukin-4 and 13 signaling 66
12.01 CXCL8 IL1B IL6 TNF
27
MAPK Pathway 72
Show member pathways
 11.99 IL1B TLR4 TLR9
28
Spinal Cord Injury 1
11.99 CXCL8 IL1B IL6 TLR4 TNF
29
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.96 IL6 THPO TNF
30
Bacterial infections in CF airways 22
Show member pathways
 11.95 CXCL8 IL1B IL6 TLR4 TLR9 TNF
31
AGE-RAGE signaling pathway in diabetic complications 37
11.94 CXCL8 IL1B IL6 TNF
32
TNF signaling pathway 37
11.93 IL1B IL6 TNF
33
Hematopoietic cell lineage 37
11.93 IL1B IL6 THPO TNF
34
Senescence and Autophagy in Cancer 1
11.92 CXCL8 IL1B IL6
35
NF-kappa B signaling pathway 37
11.91 CXCL8 IL1B TLR4 TNF
36
HIF-1 signaling pathway 37
11.89 EGF IL6 TLR4
37
Salmonella infection (KEGG) 37
11.86 CXCL8 IL1B IL6 TLR4
38
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.85 CXCL8 IL6 TLR4
39
Amoebiasis 37
11.84 CXCL8 IL1B IL6 TLR4 TNF
40
Dendritic Cells Developmental Lineage Pathway 65
11.78 IL1B IL6 TLR9 TNF
41
Rheumatoid arthritis 37
11.76 CXCL8 IL1B IL6 TLR4 TNF
42
Bladder cancer 37 1
11.74 CXCL8 EGF HBEGF
43
LPA receptor mediated events 1
11.69 CXCL8 HBEGF IL6
44
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.68 CXCL8 IL1B IL6 TNF
45
Pertussis 37
11.65 CXCL8 IL1B IL6 TLR4 TNF
46
Photodynamic therapy-induced AP-1 survival signaling. 1
11.57 HBEGF IL6 TNF
47
MSP-RON Signaling 64
11.54 IL1B TLR4 TNF
48
Interleukin-10 signaling 66
11.53 CXCL8 IL1B IL6 TNF
49
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.51 IL1B IL6 TNF
50
Development and heterogeneity of the ILC family 1
11.35 IL1B IL6 TNF
Sources

GO Terms for Perinatal Necrotizing Enterocolitis

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Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CRP CXCL8 EGF HBEGF IL1B IL6
2 extracellular space GO:0005615 9.36 CRP CXCL8 EGF HBEGF IL1B IL6

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.99 CXCL8 IL1B IL6 TNF
2 MAPK cascade GO:0000165 9.95 EGF HBEGF IL1B TNF
3 regulation of signaling receptor activity GO:0010469 9.95 CXCL8 HBEGF IL1B IL6 THPO TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.9 IL1B TLR4 TLR9 TNF
5 positive regulation of protein kinase B signaling GO:0051897 9.88 EGF HBEGF THPO TNF
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.87 IL1B IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 TNF
8 defense response to Gram-negative bacterium GO:0050829 9.84 IL6 TLR4 TLR9
9 cellular response to lipopolysaccharide GO:0071222 9.84 CXCL8 IL6 TLR4 TNF
10 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 EGF HBEGF IL6
11 positive regulation of inflammatory response GO:0050729 9.82 PLA2G7 TLR4 TLR9
12 activation of MAPK activity GO:0000187 9.81 EGF IL1B TLR4 TNF
13 inflammatory response GO:0006954 9.8 CRP CXCL8 IL1B IL6 TLR4 TLR9
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 HBEGF IL6 TNF
15 positive regulation of interferon-gamma production GO:0032729 9.77 IL1B TLR4 TNF
16 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 IL1B IL6 TLR4 TLR9 TNF
17 positive regulation of JNK cascade GO:0046330 9.76 IL1B TLR4 TLR9 TNF
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.75 IL1B TLR4 TNF
19 acute-phase response GO:0006953 9.72 CRP IL6 SIGIRR
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.71 IL1B TLR4 TLR9 TNF
21 embryonic digestive tract development GO:0048566 9.7 CXCL8 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 IL1B TLR4 TNF
24 positive regulation of gene expression GO:0010628 9.7 CRP EGF IL1B IL6 TLR4 TLR9
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
26 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.69 TLR4 TLR9
27 negative regulation of ERBB signaling pathway GO:1901185 9.68 EGF HBEGF
28 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 TLR9
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL1B TNF
30 I-kappaB phosphorylation GO:0007252 9.67 TLR4 TLR9
31 negative regulation of interleukin-6 production GO:0032715 9.67 TLR4 TLR9 TNF
32 regulation of cytokine secretion GO:0050707 9.66 TLR4 TLR9
33 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.66 IL1B TLR9
34 positive regulation of chemokine biosynthetic process GO:0045080 9.64 IL1B TNF
35 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.64 TLR4 TNF
36 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
37 positive regulation of interferon-beta biosynthetic process GO:0045359 9.62 TLR4 TLR9
38 positive regulation of interleukin-8 production GO:0032757 9.62 IL1B TLR4 TLR9 TNF
39 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
40 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
41 negative regulation of lipid storage GO:0010888 9.61 CRP IL6 TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
43 negative regulation of chemokine biosynthetic process GO:0045079 9.56 IL6 SIGIRR
44 positive regulation of chemokine production GO:0032722 9.26 IL6 TLR4 TLR9 TNF
45 positive regulation of interleukin-6 production GO:0032755 9.02 IL1B IL6 TLR4 TLR9 TNF
46 immune response GO:0006955 10.03 CXCL8 IL1B IL6 TLR4 TNF

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 EGF HBEGF IL6 THPO
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B TLR9
3 cytokine activity GO:0005125 9.02 CXCL8 IL1B IL6 THPO TNF
Sources

Sources for Perinatal Necrotizing Enterocolitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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