NEC
MCID: PRN019
MIFTS: 55

Perinatal Necrotizing Enterocolitis (NEC)

Categories: Fetal diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

MalaCards integrated aliases for Perinatal Necrotizing Enterocolitis:

Name: Perinatal Necrotizing Enterocolitis 12 15
Necrotizing Enterocolitis 12 53 59 15 17 72
Enterocolitis, Necrotizing 53 44
Enterocolitis Necrotizing 12 55
Necrotizing Enterocolitis in Fetus or Newborn 12
Pseudomembranous Enterocolitis in Newborn 12
Perinatal Necrotising Enterocolitis 12
Nec 53

Characteristics:

Orphanet epidemiological data:

59
necrotizing enterocolitis
Prevalence: 1-5/10000 (Worldwide); Age of onset: Neonatal; Age of death: infantile;

Classifications:



External Ids:

Disease Ontology 12 DOID:8677
MeSH 44 D020345
ICD10 33 K55.3 K55.30 P77
ICD10 via Orphanet 34 P77
UMLS via Orphanet 73 C0520459
Orphanet 59 ORPHA391673
UMLS 72 C0520459

Summaries for Perinatal Necrotizing Enterocolitis

NIH Rare Diseases : 53 Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.

MalaCards based summary : Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to newborn respiratory distress syndrome and cerebral palsy. An important gene associated with Perinatal Necrotizing Enterocolitis is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and breast, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Perinatal Necrotizing Enterocolitis

Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 506)
# Related Disease Score Top Affiliating Genes
1 newborn respiratory distress syndrome 30.7 IL6 IL1B CXCL8
2 cerebral palsy 30.7 TNF IL6 IL1B
3 funisitis 30.5 IL6 IL1B CXCL8
4 fasciitis 30.5 TNF IL6 CXCL8
5 acute cystitis 30.5 IL6 CXCL8 CRP
6 esophagitis 30.4 IL6 IL1B CXCL8
7 cytomegalovirus infection 30.4 TNF IL6 IL1B CXCL8
8 cardiogenic shock 30.3 TNF IL6
9 meconium aspiration syndrome 30.1 TNF IL6 CXCL8
10 peptic esophagitis 30.1 IL1B CXCL8
11 gastroenteritis 30.1 TNF IL6 IL1B CXCL8 CRP
12 duodenal ulcer 30.0 TNF IL1B CXCL8
13 pertussis 30.0 TNF TLR4 IL6 IL1B
14 acquired immunodeficiency syndrome 29.9 TNF IL6 IL1B
15 osteomyelitis 29.9 TNF IL6 IL1B CXCL8
16 respiratory failure 29.8 TNF CXCL8 CRP
17 chorioamnionitis 29.8 TNF TLR4 IL6 IL1B CXCL8 CRP
18 bacterial sepsis 29.7 TNF TLR4 CXCL8 CRP
19 placenta disease 29.6 TLR9 IL6 IL1B CXCL8
20 crohn's disease 29.6 TNF TLR9 CRP
21 heart disease 29.5 TNF IL6 IL1B CXCL8 CRP
22 ileitis 29.4 TNF TLR4 TLR2 IL6 FABP2
23 exanthem 29.4 TNF TLR9 IL6 CRP
24 aspergillosis 29.4 TNF TLR9 TLR4 TLR2
25 toxic shock syndrome 29.3 TNF TLR4 TLR2 IL6 IL1B CXCL8
26 appendicitis 29.2 TNF IL6 IL1B CXCL8 CRP
27 colitis 29.1 TNF TLR9 TLR4 IL6 IL1B CXCL8
28 peritonitis 28.9 TNF TLR2 IL6 IL1B CXCL8 CRP
29 proteasome-associated autoinflammatory syndrome 1 28.8 TNF TLR4 TLR2 IL6 IL1B CXCL8
30 mouth disease 28.5 TNF TLR9 TLR4 IL6 IL1B CRP
31 inflammatory bowel disease 28.5 TNF TLR4 TLR2 IL6 IL1B CXCL8
32 lung disease 28.4 TNF TLR9 TLR2 IL6 IL1B CXCL8
33 meningitis 28.4 TNF TLR9 TLR2 IL6 IL1B CXCL8
34 intestinal disease 28.1 TNF TLR9 TLR4 IL6 IL1B CXCL8
35 gastrointestinal system disease 27.8 TNF TLR9 TLR4 IL6 IL1B HBEGF
36 bacterial infectious disease 27.5 TNF TLR9 TLR4 TLR2 IL6 IL1B
37 neuroendocrine carcinoma of pancreas 11.3
38 enterocolitis 11.0
39 overgrowth syndrome 10.6
40 cold agglutinin disease 10.5 IL6 CRP
41 intestinal obstruction 10.5
42 pouchitis 10.5 TLR4 CXCL8
43 mycobacterium chelonae 10.5 TLR2 CXCL8
44 acute transverse myelitis 10.5 IL6 CXCL8
45 myasthenic syndrome, congenital, 1a, slow-channel 10.5 CXCL8 CRP
46 scorpion envenomation 10.5 TNF IL6
47 mycobacterium marinum 10.5 TLR2 CXCL8
48 cryopyrin-associated periodic syndrome 10.4 IL6 CRP
49 mycobacterium kansasii 10.4 TLR2 CXCL8
50 metabolic acidosis 10.4

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to Perinatal Necrotizing Enterocolitis

Symptoms & Phenotypes for Perinatal Necrotizing Enterocolitis

MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 CRP FABP2 HBEGF IL1B IL6 OCLN
2 digestive/alimentary MP:0005381 9.86 EGF IL6 OCLN SIGIRR TLR2 TLR4
3 immune system MP:0005387 9.73 CRP EGF IL1B IL6 OCLN PLA2G7
4 integument MP:0010771 9.23 EGF HBEGF IL1B IL6 PRDM6 TLR2

Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

Drugs for Perinatal Necrotizing Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 226)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Histamine Approved, Investigational Phase 4 51-45-6 774
4
Ranitidine Approved Phase 4 66357-35-5, 66357-59-3 3001055
5
Zinc Approved, Investigational Phase 4 7440-66-6 32051
6
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
7
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
8 Poractant alfa Approved Phase 4 129069-19-8
9 Beractant Approved Phase 4 108778-82-1
10
Sorbitol Approved Phase 4 50-70-4 5780
11
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
12 Coconut Approved Phase 4
13
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
14
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
15
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
16
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
17
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
18 Tocotrienol Investigational Phase 4 6829-55-6
19 Immunologic Factors Phase 4
20 Antibodies Phase 4
21 Immunoglobulins Phase 4
22 gamma-Globulins Phase 4
23 Immunoglobulins, Intravenous Phase 4
24 Rho(D) Immune Globulin Phase 4
25 Antiemetics Phase 4
26 Vitamin D2 Phase 4
27 Carotenoids Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29 Provitamins Phase 4
30
Picolinic acid Phase 4 98-98-6 1018
31 Ergocalciferols Phase 4
32 Calciferol Phase 4
33 BB 1101 Phase 4
34 Bone Density Conservation Agents Phase 4
35 Antacids Phase 4
36
Stevioside Phase 4 57817-89-7 548198
37 Stevia Phase 4
38
Histamine Phosphate Phase 4 51-74-1 65513
39 Histamine Antagonists Phase 4
40 Anti-Ulcer Agents Phase 4
41 Bismuth tripotassium dicitrate Phase 4
42 Histamine H2 Antagonists Phase 4
43
Bismuth Phase 4 7440-69-9 16682734 105143
44 Ranitidine bismuth citrate Phase 4
45 Micronutrients Phase 4
46 Trace Elements Phase 4
47 Vitamins Phase 4
48 Nutrients Phase 4
49 Dermatologic Agents Phase 4
50 Astringents Phase 4

Interventional clinical trials:

(show top 50) (show all 318)
# Name Status NCT ID Phase Drugs
1 The Effect of Withholding Feeds During Red Blood Cell Transfusion on Development of TRAGI in Very Low Birth Weight Infants Unknown status NCT02132819 Phase 4
2 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of Inflammation Unknown status NCT01765998 Phase 4 Probiotic;Placebo
3 THE EFFECT OF SUSTAINED LUNG INFLATION MANEUVER APPLIED THROUGH NASAL PRONG ON EARLY AND LATE RESPIRATORY MORBIDITIES IN PRETERM INFANTS Unknown status NCT02887924 Phase 4
4 Systematic Randomized , Single Blinded, Placebo-Controlled Trial of Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
5 A Randomized Trial to Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates in Developing Countries Completed NCT01403623 Phase 4
6 Randomized Evaluation of the Use of Plastic Bags to Prevent Neonatal Hypothermia in Developing Countries-Part IV Completed NCT01604447 Phase 4
7 A Randomized Double-Blinded Study Comparing the Impact of One Versus Two Courses of Antenatal Steroids on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
8 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
9 Phase 4 Study of Use of High-dose Intravenous Immune Globulin for Prevent Hyperbilirubinemia Due Rh Hemolytic Disease in Newborns Infants Completed NCT00288600 Phase 4 Intravenous Immunoglobulin;Normal saline solution
10 The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
11 Early Sodium Intake in Preterm Newborns; Randomized Clinical Trial Recruiting NCT04035564 Phase 4 Sodium < 1mEq/kg/day;Sodium 5mEq/kg/day
12 Stress Ulcer Prophylaxis Versus Placebo - a Blinded Randomized Control Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease Recruiting NCT03667703 Phase 4 Ranitidine;Placebo
13 Oral Zinc Supplementation Improving Growth and Reducing Morbidity on Very Low Birth Weight Infant Not yet recruiting NCT04050488 Phase 4 Zinc Sulfate;Placebos
14 Personalized Versus Standardized Parenteral Nutrition for Preterm Infants With a Birth Weight Greater Than 1250 Grams: a Multicenter Randomized Phase IV Clinical Trial Not yet recruiting NCT03693287 Phase 4 Standardized-parenteral nutrition (S-PN);Personalized-parenteral nutrition (P-PN)
15 Impact of Early Postnatal Sodium Supplementation on Weight Gain in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4 Sodium chloride;Placebo
16 Phase 4 Study of Curosurf (Poractant) and Survanta (Beractant) Surfactant Treatment in Very Premature Infants With Respiratory Distress Syndrome. Terminated NCT00767039 Phase 4 Survanta (beractant);Curosurf (poractant)
17 Effects of the Use of a Bottle and a Cup on Breast Sucking Patterns of Premature Infants: Safety and Efficacy Terminated NCT00703950 Phase 4
18 Incidence and Severity of Parenteral Nutrition Associated Cholestasis in Neonates Subjected to Major Surgery, Using Two Mixed Intravenous Lipid Emulsions Terminated NCT02633384 Phase 4
19 Randomized Trial on Efficacy and Safety of the Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth (ACG Trial) Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)
20 A Pilot Study to Compare the Use of Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Withdrawn NCT02774317 Phase 4
21 Role Of Saccharomyces Boulardii in Preventin Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3 Saccharomyces boulardii;Placebo
22 Effect of Cysteine Supplementation on Glutathione Production in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
23 Efficacy and Safety of Probiotics in Neonatal Hyperbilirubinemia Unknown status NCT03266913 Phase 3 Probiotic
24 Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus Closure in Preterm Infants. A Prospective, Randomized, Controlled, Double Blind, Multicenter Clinical Trial. Unknown status NCT02056223 Phase 2, Phase 3 Intravenous paracetamol;Intravenous ibuprofen
25 Nasal Intermittent Mandatory Ventilation Versus Continuous Positive Airway Pressure After Extubation of Very Low Birth Weight Infants of the NEOCOSUR Network. Unknown status NCT01778829 Phase 3
26 Role Of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis in Very Low Birth Weight Infants Completed NCT01531179 Phase 3 Lactobacillus reuteri;Placebo
27 Role of Probiotics for Prevention of Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants: A Double Blind Randomized Controlled Trial Completed NCT02650869 Phase 3
28 Effect of Vitamin A in the Treatment of Sepsis and Necrotizing Enterocolitis in Hospitalized Neonates Completed NCT00707785 Phase 3
29 Nosocomial Infections and Necrotizing Enterocolitis in Preterm Neonates Treated With Lactobacillus Acidophilus and Bifidobacterium Infantis in An Intensive Care Unit : A Randomized Controlled Study Completed NCT01340469 Phase 3
30 The Efficacy of Symbiotic Preparation on Cytokines Which Act on Necrotising Enterocolitis Pathogenesis in Very Low Birth Weight Infants Completed NCT01899677 Phase 3 symbiotic
31 The Use of Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature and Very-low Birth Weight Infants Completed NCT01868737 Phase 3
32 Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) Completed NCT00009646 Phase 3 indomethacin;Indomethacin;Placebo
33 Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth Completed NCT02350231 Phase 2, Phase 3 The progesterone vaginal pessary;Tonics group
34 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
35 Pentoxifylline Therapy of Late-onset Sepsis in Preterm Infants: A Randomized Controlled Trial. Completed NCT02163174 Phase 3 Pentoxifylline (PTX);Placebo
36 A Single Blinded Study on the Effect of Saccharomyces Boulardii CNCM I-745 on Growth and Development in Preterm Infants Completed NCT02310425 Phase 3 S. boulardii;Placebo
37 Comparison of Intravenous Ibuprofen vs. Continuous Indomethacin in the Treatment of Patent Ductus Arteriosus Completed NCT00485160 Phase 3 Continuous indomethacin;ibuprofen
38 Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy/Safety of CY-1503 (Cylexin) in Prevention of Reperfusion Injury in Neonates/Infants Undergoing Hypothermic Cardiopulmonary Bypass Completed NCT00226369 Phase 2, Phase 3 CY-1503
39 Decreasing Rates of Illnesses in Kids (DRINK) Completed NCT00356382 Phase 3 Lactobacillus (L.) casei
40 Inhaled NO in Prevention of Chronic Lung Disease Completed NCT00000548 Phase 3
41 Early Vitamin D Supplementation for Prevention of Respiratory Morbidity in Extremely Preterm Infants: A Randomized Clinical Trial Completed NCT01600430 Phase 2, Phase 3
42 Randomized Clinical Trial of Dexamethasone Therapy in Very-Low-Birth-Weight Infants at Risk for Chronic Lung Disease (CLD) Completed NCT00011362 Phase 3 Dexamethasone Early;Dexamethasone Late
43 Effect of Early Enteral Supplementation of L-arginine and Glutamine on Preterm Neonate Completed NCT01263041 Phase 2, Phase 3 Glutamine;l-arginine
44 A Randomized Controlled Trial on the Effectiveness of Inhaled Nitrous Oxide for Pain Relief During ROP Screening Exam in the Pre-term Infant Completed NCT00623220 Phase 3
45 High-dose Ibuprofen for Patent Ductus Arteriosus in Extremely Preterm Infants: a Randomized Controlled Study Completed NCT01243996 Phase 2, Phase 3 Ibuprofen
46 A Randomized, Double Blind, Parallel-group, Placebo Controlled Study to Evaluate the Efficacy and Safety of IBP-9414 in Premature Infants 500-1500g Birth Weight in the Prevention of Necrotizing Enterocolitis - The Connection Study Recruiting NCT03978000 Phase 3 IBP-9414;Placebo
47 Can Bovine Lactoferrin Prevent Neonatal Infections in Low Birth Weight Babies in Karachi, Sindh, Pakistan. Recruiting NCT03431558 Phase 3 Glucon-D 99.4% (Placebo)
48 Do Probiotics Modulate the Intestinal Microbiome of Extremely Preterm Infants? Recruiting NCT03422562 Phase 3
49 Lactoferrin Infant Feeding Trial - LIFT_Canada Recruiting NCT03367013 Phase 3
50 A Double Blinded Randomized Controlled Trial of Early Use of Oral Progesterone in All Women for Prevention of Preterm Delivery in Singleton Pregnancy (SINPRO Study) Recruiting NCT03428685 Phase 2, Phase 3 Dydrogesterone Oral Tablet;Placebo Oral Tablet

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Cochrane evidence based reviews: enterocolitis, necrotizing

Genetic Tests for Perinatal Necrotizing Enterocolitis

Anatomical Context for Perinatal Necrotizing Enterocolitis

MalaCards organs/tissues related to Perinatal Necrotizing Enterocolitis:

41
Colon, Heart, Breast, Lung, Brain, Liver, Neutrophil

Publications for Perinatal Necrotizing Enterocolitis

Articles related to Perinatal Necrotizing Enterocolitis:

(show top 50) (show all 6331)
# Title Authors PMID Year
1
Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis. 9 38
20485148 2010
2
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. 9 38
20464748 2010
3
A systematic review of serologic tests in the diagnosis of necrotizing enterocolitis. 9 38
19944232 2009
4
Heat susceptibility of interleukin-10 and other cytokines in donor human milk. 9 38
19366315 2009
5
Heparin-binding EGF-like growth factor is a potent dilator of terminal mesenteric arterioles. 9 38
19389413 2009
6
Can lactoferrin prevent neonatal sepsis and necrotizing enterocolitis? 9 38
19485792 2009
7
Preclinical neonatal rat studies of heparin-binding EGF-like growth factor in protection of the intestines from necrotizing enterocolitis. 9 38
19127210 2009
8
Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates. 9 38
19160324 2009
9
Effects of sepsis on neonatal thrombopoiesis. 9 38
18552713 2008
10
Heparin-binding epidermal growth factor-like growth factor gene disruption is associated with delayed intestinal restitution, impaired angiogenesis, and poor survival after intestinal ischemia in mice. 9 38
18558204 2008
11
Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation. 9 38
18239063 2008
12
Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis. 9 38
18346534 2008
13
Tissue distribution and plasma clearance of heparin-binding EGF-like growth factor (HB-EGF) in adult and newborn rats. 9 38
16364500 2006
14
Heparin-binding EGF-like growth factor (HB-EGF) and necrotizing enterocolitis. 9 38
16084404 2005
15
Lactoferrin-enhanced anoikis: a defense against neonatal necrotizing enterocolitis. 9 38
15950395 2005
16
Epidermal growth factor and necrotizing enterocolitis. 9 38
15183666 2004
17
Heparin-binding epidermal growth factor-like growth factor and intestinal ischemia-reperfusion injury. 9 38
14765365 2004
18
Intraluminal casein model of necrotizing enterocolitis for assessment of mucosal destruction, bacterial translocation, and the effects of allopurinol and N-acetylcysteine. 9 38
12598971 2002
19
Diminished epidermal growth factor levels in infants with necrotizing enterocolitis. 9 38
10693661 2000
20
Klebsiella pneumoniae with extended spectrum beta-lactamase activity associated with a necrotizing enterocolitis outbreak. 9 38
10571430 1999
21
Plasma intestinal fatty acid binding protein in neonates with necrotizing enterocolitis: a pilot study. 9 38
10549746 1999
22
Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation. 9 38
10483903 1999
23
The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis. 9 38
9396557 1997
24
Clinical applications of epidermal growth factor. 9 38
8590139 1995
25
Presence of platelet-activating factor-acetylhydrolase in milk. 9 38
8228643 1993
26
Effect of necrotizing enterocolitis on urinary epidermal growth factor levels. 9 38
2058613 1991
27
Efficacy and safety of oral paracetamol versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants: a randomized controlled trial. 38
29695206 2019
28
Acute kidney injury in preterm infants with necrotizing enterocolitis. 38
29631454 2019
29
Does fortification of pasteurized donor human milk increase the incidence of necrotizing enterocolitis among preterm neonates? A randomized controlled trial. 38
29618272 2019
30
Meta-analysis of Oxygenation Saturation Targeting Trials: Do Infant Subgroups Matter? 38
31345548 2019
31
Species identification and molecular characterization of Cronobacter spp. isolated from food imported over nine years into Beijing, China. 38
31027763 2019
32
Early versus delayed umbilical cord clamping on maternal and neonatal outcomes. 38
31203386 2019
33
Noninvasive Ventilation in the Age of Surfactant Administration. 38
31345543 2019
34
Achieved Oxygenation Saturations and Outcome in Extremely Preterm Infants. 38
31345550 2019
35
Development of a Core Outcome Set and Minimum Reporting Set for intervention studies in growth restriction in the NEwbOrN (COSNEON): study protocol for a Delphi study. 38
31420053 2019
36
Association between fetal sex, birthweight percentile and adverse pregnancy outcome. 38
31424085 2019
37
Primary, secondary, and tertiary preventions of preterm birth with cervical cerclage. 38
31056734 2019
38
Toll Like Receptor 4 Mediated Lymphocyte Imbalance Induces Nec-Induced Lung Injury. 38
30148762 2019
39
The Inadequate Oxygen Delivery Index and Low Cardiac Output Syndrome Score As Predictors of Adverse Events Associated With Low Cardiac Output Syndrome Early After Cardiac Bypass. 38
31033863 2019
40
[Effect of different feeding initiation formulas on very low birth weight infants]. 38
31416502 2019
41
Outcomes after implementing restrictive blood transfusion criteria in extremely premature infants. 38
31222156 2019
42
Outcomes of singleton small for gestational age preterm infants exposed to maternal hypertension: a retrospective cohort study. 38
31086284 2019
43
SNAP-II for prediction of mortality and morbidity in extremely preterm infants. 38
29526142 2019
44
[Breastfeeding promotion strategies study on preterm infants in the neonatal intensive care unit]. 38
31420627 2019
45
Prophylactic Sildenafil in Preterm Infants at Risk of Bronchopulmonary Dysplasia: A Pilot Randomized, Double-Blinded, Placebo-Controlled Trial. 38
31414269 2019
46
Clostridia and necrotizing enterocolitis in preterm neonates. 38
30980889 2019
47
Recurrent intestinal ischemia following surgery for gastric and duodenal perforations: a case report. 38
31372842 2019
48
Maternal IgA is necessary for preventing necrotizing enterocolitis. 38
31263236 2019
49
Mother's Touch: Milk IgA and Protection from Necrotizing Enterocolitis. 38
31415742 2019
50
Ghrelin ameliorates the phenotype of newborn rats induced with mild necrotizing enterocolitis. 38
31386261 2019

Variations for Perinatal Necrotizing Enterocolitis

Expression for Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for Perinatal Necrotizing Enterocolitis

Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 TNF TLR9 TLR4 TLR2 SIGIRR IL6
2
Show member pathways
13.41 TNF TLR9 TLR4 TLR2 THPO IL6
3
Show member pathways
13.3 TNF THPO PLA2G7 IL6 IL1B HBEGF
4
Show member pathways
13.23 TNF TLR9 TLR4 TLR2 IL1B HBEGF
5
Show member pathways
13.09 TNF TLR9 TLR4 TLR2 SIGIRR IL6
6
Show member pathways
12.98 TNF TLR4 TLR2 IL6 IL1B CXCL8
7
Show member pathways
12.97 TNF TLR4 TLR2 IL6 EGF
8
Show member pathways
12.78 TNF TLR4 IL6 IL1B CXCL8
9
Show member pathways
12.65 TNF TLR9 TLR4 TLR2 SIGIRR IL1B
10
Show member pathways
12.63 TNF TLR4 TLR2 IL6 IL1B
11
Show member pathways
12.59 TNF TLR9 TLR4 TLR2 THPO IL6
12 12.55 TNF TLR9 TLR2 IL1B
13
Show member pathways
12.45 TLR9 TLR4 TLR2 SIGIRR EGF
14
Show member pathways
12.37 TNF TLR2 IL6 IL1B CXCL8
15
Show member pathways
12.36 TNF IL6 IL1B CRP
16
Show member pathways
12.35 TNF TLR4 IL6 IL1B CXCL8
17 12.33 TNF TLR4 TLR2 HBEGF
18
Show member pathways
12.3 TNF THPO IL6 IL1B HBEGF CXCL8
19
Show member pathways
12.29 TNF TLR4 TLR2 IL1B
20
Show member pathways
12.29 TNF TLR9 TLR4 TLR2 IL6 CXCL8
21
Show member pathways
12.25 TLR9 TLR4 TLR2 OCLN IL1B CXCL8
22
Show member pathways
12.24 TNF TLR9 IL6 IL1B
23 12.24 TNF TLR9 TLR4 TLR2 IL6 IL1B
24
Show member pathways
12.22 TNF TLR2 SIGIRR IL6 IL1B CXCL8
25 12.21 TNF IL6 IL1B CXCL8
26 12.15 TNF TLR9 TLR4 TLR2 IL6 EGF
27
Show member pathways
12.11 THPO IL6 IL1B EGF CXCL8
28
Show member pathways
12.09 TNF TLR4 TLR2 IL6 IL1B
29
Show member pathways
12.07 TLR9 TLR4 TLR2 IL1B
30 12.06 TNF TLR4 IL6 IL1B CXCL8
31 12.03 TNF IL6 IL1B CXCL8
32
Show member pathways
12 TNF TLR9 TLR4 TLR2 IL6 IL1B
33 11.98 TNF THPO IL6
34 11.96 TNF IL6 IL1B
35 11.96 TNF IL6 IL1B CXCL8
36 11.96 TNF TLR4 IL1B CXCL8
37 11.94 TLR4 IL6 EGF
38 11.94 TNF THPO IL6 IL1B
39 11.93 IL6 IL1B CXCL8
40
Show member pathways
11.92 TNF TLR9 TLR4 TLR2 IL6 IL1B
41
Show member pathways
11.87 TLR4 IL6 CXCL8
42 11.86 TLR4 IL6 IL1B CXCL8
43 11.83 TLR9 TLR4 TLR2
44 11.81 TNF TLR4 TLR2 IL6 IL1B CXCL8
45 11.8 TNF TLR9 IL6 IL1B
46 11.8 TNF TLR4 IL6 IL1B CXCL8
47 11.76 HBEGF EGF CXCL8
48 11.75 TNF IL6 IL1B
49
Show member pathways
11.72 TNF IL6 IL1B CXCL8
50 11.71 IL6 HBEGF CXCL8

GO Terms for Perinatal Necrotizing Enterocolitis

Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNF THPO PLA2G7 IL6 IL1B HBEGF
2 extracellular region GO:0005576 9.32 TNF TLR9 THPO PLA2G7 IL6 IL1B

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 TNF TLR9 TLR4 IL1B
2 positive regulation of protein kinase B signaling GO:0051897 9.98 TNF THPO HBEGF EGF
3 activation of MAPK activity GO:0000187 9.94 TNF TLR4 IL1B EGF
4 cellular response to lipopolysaccharide GO:0071222 9.93 TNF TLR4 IL6 IL1B CXCL8
5 positive regulation of gene expression GO:0010628 9.92 TNF TLR9 TLR4 TLR2 IL6 IL1B
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 TNF IL6 IL1B
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 IL6 HBEGF EGF
8 defense response to Gram-negative bacterium GO:0050829 9.9 TLR9 TLR4 IL6
9 defense response to Gram-positive bacterium GO:0050830 9.9 TNF TLR2 IL6 CRP
10 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 TNF TLR4 THPO
11 positive regulation of JNK cascade GO:0046330 9.89 TNF TLR9 TLR4 IL1B
12 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.88 TNF TLR9 TLR4
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.88 TNF IL6 HBEGF
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF TLR9 TLR4 TLR2 IL6 IL1B
15 positive regulation of tumor necrosis factor production GO:0032760 9.87 TLR9 TLR4 TLR2
16 inflammatory response GO:0006954 9.86 TNF TLR9 TLR4 TLR2 IL6 IL1B
17 positive regulation of interferon-gamma production GO:0032729 9.85 TNF TLR4 IL1B
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 TNF TLR4 IL1B
19 toll-like receptor signaling pathway GO:0002224 9.83 TLR9 TLR4 TLR2
20 acute-phase response GO:0006953 9.83 SIGIRR IL6 CRP
21 positive regulation of inflammatory response GO:0050729 9.83 TNF TLR9 TLR4 TLR2 PLA2G7
22 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.82 TLR9 TLR4 TLR2
23 negative regulation of interleukin-6 production GO:0032715 9.81 TNF TLR9 TLR4
24 positive regulation of interferon-beta production GO:0032728 9.8 TLR9 TLR4 TLR2
25 positive regulation of interleukin-12 production GO:0032735 9.79 TLR9 TLR4 TLR2
26 negative regulation of neurogenesis GO:0050768 9.79 TNF IL6 IL1B
27 positive regulation of interleukin-10 production GO:0032733 9.78 TLR9 TLR4 TLR2
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.77 TNF TLR9 TLR4 TLR2 IL1B
29 positive regulation of glial cell proliferation GO:0060252 9.76 TNF IL6 IL1B
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TNF TLR4 TLR2 IL1B
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.75 TLR9 TLR4 TLR2
32 embryonic digestive tract development GO:0048566 9.74 TNF CXCL8
33 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.74 TNF IL1B
34 negative regulation of lipid catabolic process GO:0050995 9.74 TNF IL1B
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 TNF IL1B
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.73 TNF IL1B
37 response to molecule of bacterial origin GO:0002237 9.73 TLR9 TLR2 CXCL8
38 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.72 TLR9 IL1B
39 cellular response to lipoteichoic acid GO:0071223 9.72 TLR4 TLR2
40 I-kappaB phosphorylation GO:0007252 9.72 TLR9 TLR4 TLR2
41 positive regulation of interferon-beta biosynthetic process GO:0045359 9.71 TLR9 TLR4
42 positive regulation of chemokine biosynthetic process GO:0045080 9.71 TNF IL1B
43 response to glucocorticoid GO:0051384 9.71 TNF IL6
44 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
45 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 TNF TLR9 TLR4
46 tumor necrosis factor production GO:0032640 9.69 TLR9 TLR2
47 positive regulation of interleukin-18 production GO:0032741 9.69 TLR9 TLR2
48 positive regulation of fever generation GO:0031622 9.69 TNF IL1B
49 negative regulation of lipid storage GO:0010888 9.69 TNF IL6 CRP
50 sequestering of triglyceride GO:0030730 9.68 TNF IL1B

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.32 TLR9 IL1B
2 signaling pattern recognition receptor activity GO:0008329 9.26 TLR9 TLR2
3 growth factor activity GO:0008083 9.26 THPO IL6 HBEGF EGF
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2
5 cytokine activity GO:0005125 9.02 TNF THPO IL6 IL1B CXCL8

Sources for Perinatal Necrotizing Enterocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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