NEC
MCID: PRN019
MIFTS: 60

Perinatal Necrotizing Enterocolitis (NEC)

Categories: Fetal diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

MalaCards integrated aliases for Perinatal Necrotizing Enterocolitis:

Name: Perinatal Necrotizing Enterocolitis 12 15
Necrotizing Enterocolitis 12 20 58 15 17 70
Enterocolitis, Necrotizing 20 44
Enterocolitis Necrotizing 12 54
Necrotizing Enterocolitis in Fetus or Newborn 12
Pseudomembranous Enterocolitis in Newborn 12
Perinatal Necrotising Enterocolitis 12
Nec 20

Characteristics:

Orphanet epidemiological data:

58
necrotizing enterocolitis
Prevalence: 1-5/10000 (Worldwide); Age of onset: Neonatal; Age of death: infantile;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


Summaries for Perinatal Necrotizing Enterocolitis

GARD : 20 Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.

MalaCards based summary : Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to enterocolitis and intestinal perforation. An important gene associated with Perinatal Necrotizing Enterocolitis is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Iron and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and liver, and related phenotypes are premature birth and hyponatremia

Related Diseases for Perinatal Necrotizing Enterocolitis

Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 885)
# Related Disease Score Top Affiliating Genes
1 enterocolitis 32.6 TNF TLR4 IL6 IL10 FABP2 CXCL8
2 intestinal perforation 31.7 TNF TLR4 IL6 FABP2 CRP
3 intestinal obstruction 31.2 TNF IL6 CRP
4 ileus 31.1 TNF IL6 IL1B IL10 CRP
5 human cytomegalovirus infection 31.0 IL6 IL1B CXCL8
6 disseminated intravascular coagulation 30.9 TNF IL6 IL10 CRP
7 exudative vitreoretinopathy 1 30.9 TNF OCLN IL6 IL1B
8 liver disease 30.9 TNF THPO IL6 IL1B CXCL8
9 urinary tract infection 30.9 TLR4 CRP
10 compartment syndrome 30.8 TNF IL6 FABP2 CRP
11 gastroenteritis 30.8 TNF IL6 IL1B IL10 CXCL8 CRP
12 peritonitis 30.7 TNF TLR4 TLR2 IL6 IL1B IL10
13 fasciitis 30.7 TNF IL6 CXCL8
14 chorioamnionitis 30.7 TNF TLR4 IL6 IL1B IL10 CXCL8
15 clostridium difficile colitis 30.7 LTF IL1B CRP CCR6
16 deficiency anemia 30.6 TNF THPO LTF IL6 CRP CCR6
17 neutropenia 30.6 TNF THPO IL6 IL1B IL10 CXCL8
18 milk allergy 30.6 TNF IL10 CSN1S1
19 cerebral palsy 30.6 TNF TLR4 IL6 IL1B IL10 CXCL8
20 necrotizing fasciitis 30.6 IL6 IL1B CXCL8 CRP
21 pre-eclampsia 30.6 TNF TLR4 IL6 IL1B IL10 HBEGF
22 diarrhea 30.5 TNF TLR4 OCLN IL6 IL1B IL10
23 vasculitis 30.5 TNF LTF IL6 CRP
24 congestive heart failure 30.4 TNF IL6 IL1B CRP
25 heart disease 30.4 TNF TLR4 TLR2 IL6 IL1B IL10
26 cellulitis 30.4 TNF IL6 CRP CCR6
27 appendicitis 30.4 TNF TLR4 IL6 IL1B IL10 CXCL8
28 thrombocytopenia 30.4 TNF TLR4 TLR2 THPO IL6 IL1B
29 cardiogenic shock 30.4 TNF IL6
30 food allergy 30.4 TNF TLR4 TLR2 IL10 CXCL8 CSN1S1
31 meconium aspiration syndrome 30.3 TNF IL6 CXCL8
32 gastroesophageal reflux 30.3 TNF IL6 IL1B EGF CXCL8
33 pulmonary hypertension 30.3 TNF IL6 IL1B CXCL8 CRP
34 genital herpes 30.3 TLR2 IL10 CCR6
35 cyclic neutropenia 30.3 TNF IL1B CXCL8
36 lung disease 30.3 TNF TLR4 TLR2 IL6 IL1B IL10
37 respiratory failure 30.2 TNF TLR4 IL6 IL1B IL10 CXCL8
38 mucositis 30.2 IL1B IL10 EGF
39 portal hypertension 30.2 TNF TLR4 THPO CXCL8
40 pertussis 30.1 TNF TLR4 IL6 IL1B IL10 CXCL8
41 disease by infectious agent 30.1 TNF TLR4 TLR2 IL6 IL1B IL10
42 proteasome-associated autoinflammatory syndrome 1 30.1 TNF TLR4 TLR2 IL6 IL1B IL10
43 diphtheria 30.1 TNF IL1B HBEGF EGF
44 peptic esophagitis 30.1 TNF IL6 IL1B CXCL8
45 funisitis 30.1 TNF IL6 IL1B IL10 CXCL8 CRP
46 bilirubin metabolic disorder 30.1 TNF IL6 IL1B CRP
47 toxic shock syndrome 30.1 TNF TLR4 TLR2 IL6 IL1B IL10
48 acute cystitis 30.1 TNF TLR4 IL6 IL1B IL10 CXCL8
49 mouth disease 30.1 TLR4 IL6 IL10 CRP CCR6
50 myocarditis 30.1 TNF TLR4 IL6 IL1B IL10

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to Perinatal Necrotizing Enterocolitis

Symptoms & Phenotypes for Perinatal Necrotizing Enterocolitis

Human phenotypes related to Perinatal Necrotizing Enterocolitis:

58 31 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 premature birth 58 31 hallmark (90%) Very frequent (99-80%) HP:0001622
2 hyponatremia 58 31 frequent (33%) Frequent (79-30%) HP:0002902
3 neutropenia 58 31 frequent (33%) Frequent (79-30%) HP:0001875
4 small for gestational age 58 31 frequent (33%) Frequent (79-30%) HP:0001518
5 abdominal distention 58 31 frequent (33%) Frequent (79-30%) HP:0003270
6 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
7 food intolerance 58 31 frequent (33%) Frequent (79-30%) HP:0012537
8 bloody diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0025085
9 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
10 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
11 ascites 58 31 occasional (7.5%) Occasional (29-5%) HP:0001541
12 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
13 increased serum lactate 58 31 occasional (7.5%) Occasional (29-5%) HP:0002151
14 apnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002104
15 lethargy 58 31 occasional (7.5%) Occasional (29-5%) HP:0001254
16 metabolic acidosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001942
17 abnormal heart morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001627
18 gastroschisis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001543
19 edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0000969
20 peritonitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002586
21 hyperglycemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0003074
22 disseminated intravascular coagulation 58 31 occasional (7.5%) Occasional (29-5%) HP:0005521
23 temperature instability 58 31 occasional (7.5%) Occasional (29-5%) HP:0005968
24 bradycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001662
25 neonatal sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0040187
26 shock 58 31 occasional (7.5%) Occasional (29-5%) HP:0031273
27 diarrhea 58 Frequent (79-30%)
28 acidosis 58 Occasional (29-5%)
29 abnormal glucose homeostasis 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 CCR6 CRP FABP2 GOT2 HBEGF IL10
2 digestive/alimentary MP:0005381 9.91 EGF IL10 IL6 OCLN SIGIRR TFF3
3 immune system MP:0005387 9.83 CCR6 CRP EGF IL10 IL1B IL6
4 neoplasm MP:0002006 9.17 IL10 IL1B IL6 LTF TLR2 TLR4

Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

Drugs for Perinatal Necrotizing Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 115)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925 29936
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
4
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
5
Zinc Approved, Investigational Phase 4 7440-66-6 32051
6
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
7
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
8
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
9
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
10
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
11 Trace Elements Phase 4
12 Nutrients Phase 4
13 Micronutrients Phase 4
14 Vitamins Phase 4
15 Anti-Inflammatory Agents Phase 4
16 Hormones Phase 4
17 Calcium, Dietary Phase 4
18 Chelating Agents Phase 4
19 Antiemetics Phase 4
20 Carotenoids Phase 4
21 Hormone Antagonists Phase 4
22 Iron Chelating Agents Phase 4
23 glucocorticoids Phase 4
24 Calciferol Phase 4
25 Antineoplastic Agents, Hormonal Phase 4
26
Picolinic acid Phase 4 98-98-6 1018
27 Provitamins Phase 4
28 Antioxidants Phase 4
29 Protective Agents Phase 4
30 Antibiotics, Antitubercular Phase 4
31 Anti-Bacterial Agents Phase 4
32 Anti-Infective Agents Phase 4
33 Gentamicins Phase 4
34 Dermatologic Agents Phase 4
35
Calcium Nutraceutical Phase 4 7440-70-2 271
36
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
37
Ursodeoxycholic acid Approved, Investigational Phase 2, Phase 3 128-13-2 31401
38
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
39
Azithromycin Approved Phase 3 83905-01-5 55185 447043
40
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
41
Clarithromycin Approved Phase 3 81103-11-9 84029
42
Cysteine Approved, Nutraceutical Phase 2, Phase 3 52-90-4 5862
43
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4 445354
44 Amino-acid, glucose, and electrolyte solution Phase 2, Phase 3
45 Parenteral Nutrition Solutions Phase 2, Phase 3
46 Retinol palmitate Phase 3
47 retinol Phase 3
48
Bilirubin Phase 2, Phase 3 635-65-4 5280352
49 Gastrointestinal Agents Phase 2, Phase 3
50 Pharmaceutical Solutions Phase 3

Interventional clinical trials:

(show top 50) (show all 146)
# Name Status NCT ID Phase Drugs
1 The Effect of Withholding Feeds During Red Blood Cell Transfusion on Development of TRAGI in Very Low Birth Weight Infants Unknown status NCT02132819 Phase 4
2 The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Unknown status NCT03366584 Phase 4 Dexamethasone
3 Effect of Melatonin on Feeding Intolerance and Incidence of Necrotizing Enterocolitis in Preterm Infants Completed NCT04304807 Phase 4 Melatonin 20 mg;Traditional antibiotic treatment
4 NICU Antibiotics and Outcomes Trial Recruiting NCT03997266 Phase 4 Ampicillin;Gentamycin;Normal saline
5 Oral Zinc Supplementation Improving Growth and Reducing Morbidity on Very Low Birth Weight Infant Not yet recruiting NCT04050488 Phase 4 Zinc Sulfate;Placebos
6 Role Of Saccharomyces Boulardii in Preventin Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3 Saccharomyces boulardii;Placebo
7 Effect of Cysteine Supplementation on Glutathione Production in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
8 Effect of Vitamin A in the Treatment of Sepsis and Necrotizing Enterocolitis in Hospitalized Neonates Completed NCT00707785 Phase 3
9 Nosocomial Infections and Necrotizing Enterocolitis in Preterm Neonates Treated With Lactobacillus Acidophilus and Bifidobacterium Infantis in An Intensive Care Unit : A Randomized Controlled Study Completed NCT01340469 Phase 3
10 Role of Probiotics for Prevention of Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants: A Double Blind Randomized Controlled Trial Completed NCT02650869 Phase 3
11 Role Of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis in Very Low Birth Weight Infants Completed NCT01531179 Phase 3 Lactobacillus reuteri;Placebo
12 The Use of Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature and Very-low Birth Weight Infants Completed NCT01868737 Phase 3
13 The Efficacy of Symbiotic Preparation on Cytokines Which Act on Necrotising Enterocolitis Pathogenesis in Very Low Birth Weight Infants Completed NCT01899677 Phase 3 symbiotic
14 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
15 Evaluation of Bowel Perfusion With Contrast-Enhanced Ultrasound in Necrotizing Enterocolitis Recruiting NCT03549507 Phase 3 Sulfur hexafluoride lipid-type A microspheres
16 A Randomized, Double Blind, Parallel-group, Placebo Controlled Study to Evaluate the Efficacy and Safety of IBP-9414 in Premature Infants 500-1500g Birth Weight in the Prevention of Necrotizing Enterocolitis - The Connection Study Recruiting NCT03978000 Phase 3 IBP-9414;Placebo
17 Nordic Study on Human Milk Fortification in Extremely Preterm Infants: a Randomized Controlled Trial Recruiting NCT03797157 Phase 2, Phase 3
18 Can Bovine Lactoferrin Prevent Neonatal Infections in Low Birth Weight Babies in Karachi, Sindh, Pakistan. Recruiting NCT03431558 Phase 3 Glucon-D 99.4% (Placebo)
19 Treatment of Classic Mid-trimester Preterm Premature Rupture of Membranes (PPROM) With Oligo/Anhydramnion Between 22/0-26/0 Week of Gestation by Means of Continuous Amnioinfusion: a Multicenter Prospectiv Randomized Trial Not yet recruiting NCT04696003 Phase 3
20 Prophylactic Probiotics for the Prevention of Sepsis and NEC in Premature Infants in Colombia. A Randomized Double-Blind, Multicenter Trial Terminated NCT00727363 Phase 3
21 Therapeutic Controlled Hypothermia in the Treatment of Neonates With Severe Necrotizing Enterocolitis Unknown status NCT01330576 Phase 2
22 Heat Killed Probiotics in the Prevention of Necrotizing Enterocolitis (NEC) in Premature Neonates Unknown status NCT02796703 Phase 2
23 Prebiotics vs. Placebo in the Prevention of Necrotizing Enterocolitis in Premature Neonates Unknown status NCT00437567 Phase 2
24 Pentoxifylline in the Treatment of Necrotizing Enterocolitis in Premature Neonates Unknown status NCT00271336 Phase 2 Pentoxifylline
25 Enteral Granulocyte Colony Stimulating Factor and Erythropoietin Early in Life Increases Feeding Tolerance in Preterm Infants: A Randomized Controlled Trial Completed NCT01441427 Phase 1, Phase 2 recombinant human G-CSF, and rhEPO;rh G-CSF;rh EPO;rh G-GSF and rh EPO together;Placebo
26 Efficacy of Enteral Administration of the Docosahexaenoic Acid on Necrotizing Enterocolitis, Cytokines and Hospital Stay in Preterm Neonates Completed NCT01745510 Phase 1, Phase 2
27 Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus in Preterm infants-a Multicenter Trial Completed NCT01958320 Phase 2 NSAID
28 Comparison of 2 Different Indomethacin Dosing Protocols to Treat Infants Delivered at <28 Weeks Gestation With a Persistent Patent Ductus Arteriosus Completed NCT00187447 Phase 2 indomethacin (two different dosing regimens)
29 Incidence of Severe Necrotizing Enterocolitis in Preterm Newborns <1500g Using Probiotics Lactobacillus Boucardii. Completed NCT02226263 Phase 2
30 Erythropoietin Protects Very Preterm Infants Against Necrotizing Enterocolitis Completed NCT03919500 Phase 2 EPO;Normal saline
31 Multiple Dose Pharmacokinetic Study of Meropenem in Young Infants (<91 Days) With Suspected or Complicated Intra-abdominal Infections Completed NCT00621192 Phase 1, Phase 2 meropenem
32 A Randomized, Double Blind, Parallel-group, Dose Escalation Placebo-controlled Multicenter Study to Investigate the Safety and Tolerability of IBP-9414 Administered in Preterm Infants. Completed NCT02472769 Phase 2 IBP-9414;Placebo
33 The Effects of Lactulose Supplementation to Enteral Feedings in Premature Infants - A Pilot Study Completed NCT00616876 Phase 2 Lactulose
34 Antibiotic Effects on the Developing Microbiome, Metabolome and Morbidities in Preterm Neonates Completed NCT02784821 Phase 2 Antibiotic;Antibiotics - pre-emptive
35 Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies Completed NCT01674478 Phase 2
36 Prophylactic Probiotics to Extremely Low Birth Weight Prematures Completed NCT01603368 Phase 2
37 The Role of Lactobacillus Reuteri (L. Reuteri) in Preventing Necrotizing Enterocolitis (NEC) in Pre-term Infants Less Than 34 Weeks of Gestation Not yet recruiting NCT04541771 Phase 2 Lactobacillus Reuteri DSM 17938;Placebo
38 Phase 2 Study of Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis for Very Low Birth Weight Infants -Multi-Center Randomized Control Trial Terminated NCT00540033 Phase 2
39 An Assessment of Urinary Intestinal Fatty Acid Binding Protein as a Early Predictor of Necrotizing Enterocolitis Withdrawn NCT01805206 Phase 2
40 Enteral Administration of a Simulated Amniotic Fluid In Preventing Feeding Intolerance And Necrotizing Enterocolitis In Very Low Birth Weight Neonates Unknown status NCT02405637 Phase 1 simulated amniotic fluid 20cc/kg/day enterally;distilled water
41 Simulated Amniotic Fluid Like Solution Enterally Administrated in Neonates Recovering From GIT Surgeries Unknown status NCT03302338 Phase 1 SAFE group;placebo group
42 Safety and Effectiveness Phase 1 Study of Autologous Umbilical Cord Blood Transfusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
43 A Phase Ib Randomized, Placebo Controlled Study of the Safety and Efficacy of Once Daily Dosing of STP206 in Premature Very Low Birth Weight and Extremely Low Birth Weight Neonates Completed NCT01954017 Phase 1
44 Safety and Pharmacokinetics of Multiple Dose Metronidazole in Premature Infants Completed NCT01222585 Phase 1 Metronidazole
45 Effects of Delayed Cord Clamping in Very Low Birth Weight (VLBW) Infants Completed NCT00840983 Phase 1
46 Clostridium and Neonatal Necrotizing Enterocolitis Pathophysiology : Clinical and Molecular Approaches Unknown status NCT02444624
47 The Efficacy and Mechanisms of Oral Probiotics in Preventing Necrotizing Enterocolitis Among Very Low Birth Weight Infants With Formula-feeding Unknown status NCT02552706
48 Administration of Arginine Supplementation in Preterm Infants and Measurement of Fecal Calprotectin as an Inflammatory Marker of the Intestine Unknown status NCT01336998
49 Evaluation of the Risk of Necrotizing Enterocolitis in Fetuses With Intrauterine Growth Restriction. Unknown status NCT03869827
50 Proximal Remnant Intestinal Colonization in Newborn Infants With Enterostomy: a Longitudinal Study Unknown status NCT03340259

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Cochrane evidence based reviews: enterocolitis, necrotizing

Genetic Tests for Perinatal Necrotizing Enterocolitis

Anatomical Context for Perinatal Necrotizing Enterocolitis

MalaCards organs/tissues related to Perinatal Necrotizing Enterocolitis:

40
Heart, Bone, Liver, Neutrophil, Colon, Skin, Lung

Publications for Perinatal Necrotizing Enterocolitis

Articles related to Perinatal Necrotizing Enterocolitis:

(show top 50) (show all 7084)
# Title Authors PMID Year
1
Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis. 54 61
20485148 2010
2
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. 61 54
20464748 2010
3
A systematic review of serologic tests in the diagnosis of necrotizing enterocolitis. 54 61
19944232 2009
4
Heat susceptibility of interleukin-10 and other cytokines in donor human milk. 54 61
19366315 2009
5
Heparin-binding EGF-like growth factor is a potent dilator of terminal mesenteric arterioles. 54 61
19389413 2009
6
Can lactoferrin prevent neonatal sepsis and necrotizing enterocolitis? 61 54
19485792 2009
7
Preclinical neonatal rat studies of heparin-binding EGF-like growth factor in protection of the intestines from necrotizing enterocolitis. 54 61
19127210 2009
8
Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates. 61 54
19160324 2009
9
Effects of sepsis on neonatal thrombopoiesis. 54 61
18552713 2008
10
Heparin-binding epidermal growth factor-like growth factor gene disruption is associated with delayed intestinal restitution, impaired angiogenesis, and poor survival after intestinal ischemia in mice. 61 54
18558204 2008
11
Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation. 61 54
18239063 2008
12
Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis. 54 61
18346534 2008
13
Tissue distribution and plasma clearance of heparin-binding EGF-like growth factor (HB-EGF) in adult and newborn rats. 61 54
16364500 2006
14
Heparin-binding EGF-like growth factor (HB-EGF) and necrotizing enterocolitis. 61 54
16084404 2005
15
Lactoferrin-enhanced anoikis: a defense against neonatal necrotizing enterocolitis. 61 54
15950395 2005
16
Epidermal growth factor and necrotizing enterocolitis. 54 61
15183666 2004
17
Heparin-binding epidermal growth factor-like growth factor and intestinal ischemia-reperfusion injury. 61 54
14765365 2004
18
Intraluminal casein model of necrotizing enterocolitis for assessment of mucosal destruction, bacterial translocation, and the effects of allopurinol and N-acetylcysteine. 61 54
12598971 2002
19
Diminished epidermal growth factor levels in infants with necrotizing enterocolitis. 61 54
10693661 2000
20
Klebsiella pneumoniae with extended spectrum beta-lactamase activity associated with a necrotizing enterocolitis outbreak. 61 54
10571430 1999
21
Plasma intestinal fatty acid binding protein in neonates with necrotizing enterocolitis: a pilot study. 61 54
10549746 1999
22
Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation. 54 61
10483903 1999
23
The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis. 61 54
9396557 1997
24
Clinical applications of epidermal growth factor. 54 61
8590139 1995
25
Presence of platelet-activating factor-acetylhydrolase in milk. 54 61
8228643 1993
26
Effect of necrotizing enterocolitis on urinary epidermal growth factor levels. 54 61
2058613 1991
27
Early total enteral feeding in stable preterm infants: a systematic review and meta-analysis. 61
31248308 2021
28
The relationship between histologic chorioamnionitis and decidual macrophage polarization and their influence on outcomes of neonates born before the 32nd gestational week. 61
31258026 2021
29
Dynamics of the preterm gut microbiome in health and disease. 61
33439103 2021
30
Untwisting the complexity of midgut malrotation and volvulus ultrasound. 61
33398405 2021
31
Epidemiology of coronavirus disease 2019 in pregnancy: risk factors and associations with adverse maternal and neonatal outcomes. 61
32986989 2021
32
Prophylactic efficacy of enteral antifungal administration of miconazole for intestinal perforation, especially for necrotizing enterocolitis: a historical cohort study at a single institution. 61
32886209 2021
33
Gastrointestinal Zygomycosis in a Preterm Neonate Associated With Contaminated Probiotics. 61
33464011 2021
34
The Use of Fecal Calprotectin Testing in Paediatric Disorders: A Position Paper of the European Society for Paediatric Gastroenterology and Nutrition Gastroenterology Committee. 61
33716293 2021
35
Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo. 61
33085904 2021
36
Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada. 61
33747317 2021
37
Challenge in diagnosis of late onset necrotizing enterocolitis in a term infant: a case report. 61
33784988 2021
38
Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis. 61
33809097 2021
39
Plasma citrulline during the first 48 h after onset of necrotizing enterocolitis in preterm infants. 61
33276973 2021
40
Hepatic oxidative injury: role of mitochondrial dysfunction in necrotizing enterocolitis. 61
33547933 2021
41
Doppler ultrasound assessment of splanchnic perfusion and heart rate for the detection of necrotizing enterocolitis. 61
33580271 2021
42
Perinatal Outcome of Selective Intrauterine Growth Restriction in Monochorionic Twins: Evaluation of a Retrospective Cohort in a Developing Country. 61
33745489 2021
43
Prophylactic versus therapeutic caffeine for apnea of prematurity: a randomized controlled trial. 61
33771081 2021
44
[Clinical effect of multi-oil fat emulsion for parenteral nutrition support in extremely low birth weight infants]. 61
33691914 2021
45
[Clinical features of very preterm small-for-gestational-age infants born due to severe preeclampsia]. 61
33691918 2021
46
Anemia of prematurity: how low is too low? 61
33664467 2021
47
Causative role of mast cell and mast cell-regulatory function of disialyllacto-N-tetraose in necrotizing enterocolitis. 61
33812262 2021
48
Hematological predictors of mortality in neonates with fulminant necrotizing enterocolitis. 61
33772112 2021
49
Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. 61
33785202 2021
50
The decrease of fucosylation in intestinal epithelium is related to the development of necrotizing enterocolitis. 61
33465592 2021

Variations for Perinatal Necrotizing Enterocolitis

Expression for Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for Perinatal Necrotizing Enterocolitis

Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 TNF TLR4 TLR2 SIGIRR LTF IL6
2
Show member pathways
13.85 TNF THPO IL6 IL1B IL10 HBEGF
3
Show member pathways
13.46 TNF TLR4 TLR2 THPO IL6 IL1B
4
Show member pathways
13.38 TNF IL6 IL1B IL10 HBEGF EGF
5
Show member pathways
13.32 TNF THPO PLA2G7 IL6 IL1B IL10
6
Show member pathways
13.17 TNF TLR4 TLR2 SIGIRR OCLN IL6
7
Show member pathways
12.99 TNF TLR4 TLR2 IL6 IL1B CXCL8
8
Show member pathways
12.89 TNF TLR4 TLR2 IL6 IL1B CXCL8
9
Show member pathways
12.87 TNF IL6 IL1B IL10 CXCL8
10
Show member pathways
12.82 TNF TLR4 TLR2 OCLN IL6 IL1B
11
Show member pathways
12.77 TNF TLR4 TLR2 THPO IL6 IL1B
12
Show member pathways
12.68 TNF TLR4 TLR2 IL6 IL1B IL10
13
Show member pathways
12.68 TNF TLR4 TLR2 IL6 IL1B IL10
14
Show member pathways
12.52 TNF TLR4 TLR2 IL6 IL1B CXCL8
15
Show member pathways
12.43 THPO IL6 IL10 EGF
16 12.42 TNF TLR4 IL1B CXCL8
17
Show member pathways
12.42 TNF TLR2 IL6 IL1B CXCL8
18
Show member pathways
12.42 TNF IL6 IL10 CXCL8 CCR6
19
Show member pathways
12.4 TNF TLR4 IL6 IL1B CXCL8
20
Show member pathways
12.36 TNF IL6 IL1B CRP
21
Show member pathways
12.35 TNF TLR4 TLR2 IL6 CXCL8
22
Show member pathways
12.34 TNF TLR4 TLR2 IL1B IL10
23
Show member pathways
12.34 TNF THPO IL6 IL1B IL10 HBEGF
24 12.33 TNF TLR4 TLR2 HBEGF
25 12.32 TNF TLR4 IL6 IL1B CXCL8
26 12.3 TNF TLR4 TLR2 IL6 IL1B IL10
27 12.27 TNF TLR4 TLR2 IL6 EGF
28
Show member pathways
12.27 TNF TLR2 SIGIRR IL6 IL1B CXCL8
29
Show member pathways
12.26 TNF IL6 IL1B IL10
30 12.26 TNF IL6 IL1B IL10 CXCL8
31
Show member pathways
12.23 TNF TLR4 TLR2 IL6 IL1B CXCL8
32 12.11 TNF TLR4 IL6 IL1B CXCL8
33 12.11 TNF TLR4 IL6 IL1B IL10 CXCL8
34 12.08 TNF IL6 IL1B IL10 CXCL8
35 12.07 TNF THPO IL6 IL10
36 12.02 TNF TLR4 IL1B CXCL8
37 12 TNF IL6 IL1B CXCL8
38 11.99 TNF THPO IL6 IL1B
39 11.97 THPO IL6 HBEGF EGF
40
Show member pathways
11.95 TLR4 TLR2 IL6 IL1B
41 11.88 TNF IL1B IL10 CCR6
42 11.88 TNF TLR4 TLR2 IL6 IL1B CXCL8
43 11.85 TNF IL6 IL1B IL10
44 11.77 HBEGF EGF CXCL8
45
Show member pathways
11.76 TNF IL6 IL1B CXCL8
46
Show member pathways
11.73 TNF TLR4 TLR2 IL6 IL1B IL10
47 11.71 IL6 HBEGF CXCL8
48 11.71 TNF IL6 IL1B EGF CXCL8
49 11.68 TNF TLR4 IL6 IL1B IL10 CXCL8
50 11.62 TNF TLR4 TLR2 IL1B

GO Terms for Perinatal Necrotizing Enterocolitis

Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF THPO TFF3 PLA2G7 LTF IL6
2 cell surface GO:0009986 9.7 TNF TLR4 TLR2 LTF HBEGF GOT2
3 extracellular space GO:0005615 9.44 TNF THPO TFF3 PLA2G7 LTF IL6

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.26 TLR4 TLR2 THPO SIGIRR IL6 IL1B
2 negative regulation of cell proliferation GO:0008285 10.09 TLR2 IL6 IL1B IL10 CXCL8
3 cytokine-mediated signaling pathway GO:0019221 10.04 TNF IL6 IL1B IL10 CXCL8
4 positive regulation of protein kinase B signaling GO:0051897 9.98 TNF THPO HBEGF EGF
5 inflammatory response GO:0006954 9.98 TNF TLR4 TLR2 IL6 IL1B CXCL8
6 response to lipopolysaccharide GO:0032496 9.97 TLR4 TLR2 IL1B IL10
7 activation of MAPK activity GO:0000187 9.93 TNF TLR4 IL1B EGF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.92 TNF IL6 IL1B IL10
9 defense response to Gram-positive bacterium GO:0050830 9.91 TNF TLR2 IL6 CRP
10 response to insulin GO:0032868 9.88 TLR2 IL10 GOT2
11 regulation of insulin secretion GO:0050796 9.87 TNF IL6 IL1B
12 negative regulation of interleukin-6 production GO:0032715 9.87 TNF TLR4 IL10
13 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL10
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 TNF TLR4 TLR2 IL1B
15 positive regulation of interferon-gamma production GO:0032729 9.86 TNF TLR4 IL1B
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 TNF IL6 HBEGF
17 positive regulation of interleukin-1 beta production GO:0032731 9.85 TNF TLR4 IL6
18 humoral immune response GO:0006959 9.85 TNF LTF IL6 CCR6
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 TNF TLR4 IL1B
20 acute-phase response GO:0006953 9.83 SIGIRR IL6 CRP
21 positive regulation of interleukin-10 production GO:0032733 9.82 TLR4 TLR2 IL6
22 positive regulation of JAK-STAT cascade GO:0046427 9.8 TNF IL6 IL10
23 positive regulation of chemokine production GO:0032722 9.8 TNF TLR4 TLR2 IL6
24 positive regulation of inflammatory response GO:0050729 9.8 TNF TLR4 TLR2 PLA2G7 IL1B
25 cellular response to lipopolysaccharide GO:0071222 9.8 TNF TLR4 IL6 IL1B IL10 CXCL8
26 negative regulation of neurogenesis GO:0050768 9.77 TNF IL6 IL1B
27 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.77 TNF TLR4 IL6
28 positive regulation of interleukin-6 production GO:0032755 9.77 TNF TLR4 TLR2 IL6 IL1B
29 positive regulation of glial cell proliferation GO:0060252 9.76 TNF IL6 IL1B
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TNF TLR4 TLR2 IL1B
31 immune response GO:0006955 9.76 TNF TLR4 TLR2 IL6 IL1B IL10
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.75 TNF IL1B IL10
33 positive regulation of neuroinflammatory response GO:0150078 9.73 TNF IL6 IL1B
34 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 TNF TLR4 TLR2 LTF IL6 IL1B
35 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 TLR4 IL10
36 negative regulation of chemokine production GO:0032682 9.71 SIGIRR IL6
37 negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 9.71 SIGIRR LTF
38 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.71 TNF TLR4
39 response to molecule of bacterial origin GO:0002237 9.71 TLR2 IL10 CXCL8
40 regulation of establishment of endothelial barrier GO:1903140 9.7 TNF IL1B
41 cellular response to lipoteichoic acid GO:0071223 9.7 TLR4 TLR2
42 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
43 negative regulation of lipid storage GO:0010888 9.69 TNF IL6 CRP
44 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
45 positive regulation of fever generation GO:0031622 9.67 TNF IL1B
46 negative regulation by host of viral process GO:0044793 9.66 LTF CRP
47 sequestering of triglyceride GO:0030730 9.65 TNF IL1B
48 vascular endothelial growth factor production GO:0010573 9.65 TNF IL6 IL1B
49 positive regulation of matrix metallopeptidase secretion GO:1904466 9.64 TLR4 TLR2
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 TNF IL1B

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 THPO IL6 IL10 HBEGF EGF
2 lipopolysaccharide binding GO:0001530 9.33 TLR4 TLR2 LTF
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
4 cytokine activity GO:0005125 9.1 TNF THPO IL6 IL1B IL10 CXCL8

Sources for Perinatal Necrotizing Enterocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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