NEC
MCID: PRN019
MIFTS: 59

Perinatal Necrotizing Enterocolitis (NEC)

Categories: Fetal diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

MalaCards integrated aliases for Perinatal Necrotizing Enterocolitis:

Name: Perinatal Necrotizing Enterocolitis 12 15
Necrotizing Enterocolitis 12 52 58 15 17 71
Enterocolitis, Necrotizing 52 43
Enterocolitis Necrotizing 12 54
Necrotizing Enterocolitis in Fetus or Newborn 12
Pseudomembranous Enterocolitis in Newborn 12
Perinatal Necrotising Enterocolitis 12
Nec 52

Characteristics:

Orphanet epidemiological data:

58
necrotizing enterocolitis
Prevalence: 1-5/10000 (Worldwide); Age of onset: Neonatal; Age of death: infantile;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Disease Ontology 12 DOID:8677
MeSH 43 D020345
ICD10 32 K55.3 P77
ICD10 via Orphanet 33 P77
UMLS via Orphanet 72 C0520459
Orphanet 58 ORPHA391673
UMLS 71 C0520459

Summaries for Perinatal Necrotizing Enterocolitis

NIH Rare Diseases : 52 Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue . The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray . Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics . Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.

MalaCards based summary : Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to intestinal obstruction and periventricular leukomalacia. An important gene associated with Perinatal Necrotizing Enterocolitis is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and heart, and related phenotypes are vomiting and edema

Related Diseases for Perinatal Necrotizing Enterocolitis

Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 849)
# Related Disease Score Top Affiliating Genes
1 intestinal obstruction 31.3 TNF IL6 CRP
2 periventricular leukomalacia 31.2 TNF IL6 CPVL
3 cytomegalovirus infection 31.1 TNF IL6 IL1B CXCL8
4 compartment syndrome 31.0 TNF IL6 CRP
5 intestinal perforation 30.8 TNF TLR4 IL6 FABP2 CRP
6 milk allergy 30.7 TNF IL10 CSN1S1
7 cerebral palsy 30.7 TNF TLR4 IL6 IL1B IL10 CXCL8
8 newborn respiratory distress syndrome 30.7 PLA2G7 IL6 IL1B CXCL8 CRP
9 congestive heart failure 30.7 TNF IL6 IL1B CRP
10 liver disease 30.7 TNF THPO IL6 IL1B CXCL8
11 ileus 30.6 TNF IL6 IL1B IL10 CRP
12 clostridium difficile colitis 30.6 LTF IL1B CCR6
13 diphtheria 30.6 TNF IL1B HBEGF EGF
14 peptic esophagitis 30.6 TNF IL6 IL1B CXCL8
15 gastroenteritis 30.6 TNF TLR9 IL6 IL1B IL10 CXCL8
16 pre-eclampsia 30.6 TNF TLR4 IL6 IL1B IL10 HBEGF
17 vasculitis 30.5 TNF LTF IL6 IL10 CRP
18 meconium aspiration syndrome 30.5 TNF IL6 CXCL8
19 cow milk allergy 30.5 TNF IL10 CSN1S1
20 genital herpes 30.5 TLR2 IL10 CCR6
21 disseminated intravascular coagulation 30.5 TNF IL6 IL10 CRP
22 food allergy 30.5 TNF TLR4 TLR2 IL10 CXCL8 CSN1S1
23 cyclic neutropenia 30.5 TNF IL1B CXCL8
24 gastroesophageal reflux 30.5 TNF IL6 IL1B EGF CXCL8
25 portal hypertension 30.4 TNF TLR4 THPO CXCL8
26 neutropenia 30.4 TNF TLR4 THPO IL6 IL1B IL10
27 necrotizing fasciitis 30.4 IL6 IL1B CXCL8 CRP
28 fasciitis 30.4 TNF IL6 CXCL8 CRP
29 deficiency anemia 30.2 TNF THPO LTF IL6 CRP
30 pertussis 30.2 TNF TLR4 IL6 IL1B IL10 CXCL8
31 coronavirus infectious disease 30.2 TNF IL6 CXCL8 CRP CCR6
32 esophagitis 30.2 TNF IL6 IL1B IL10 EGF CXCL8
33 cellulitis 30.2 TNF IL6 IL1B IL10 CRP CCR6
34 funisitis 30.2 TNF IL6 IL1B IL10 CXCL8 CRP
35 bone resorption disease 30.2 TNF IL6 IL1B CRP CCR6
36 mouth disease 30.2 TLR4 IL6 IL10 CRP CCR6
37 myocarditis 30.2 TNF TLR4 IL6 IL1B IL10
38 mucositis 30.2 IL1B IL10 EGF
39 immune deficiency disease 30.1 TNF TLR9 TLR2 IL6 IL10 CCR6
40 sudden infant death syndrome 30.1 TNF IL6 IL1B IL10 CXCL8
41 toxic shock syndrome 30.1 TNF TLR4 TLR2 IL6 IL1B IL10
42 peritonitis 30.1 TNF TLR4 TLR2 IL6 IL1B IL10
43 osteomyelitis 30.1 TNF TLR4 TLR2 IL6 IL1B IL10
44 hemophagocytic lymphohistiocytosis 30.1 TNF IL10 CXCL8
45 shigellosis 30.0 TNF TLR4 LTF IL1B IL10 CXCL8
46 herpes simplex 30.0 TNF TLR9 TLR2 IL6
47 inherited metabolic disorder 30.0 TNF TLR4 IL6 IL1B CRP CCR6
48 appendicitis 30.0 TNF TLR4 IL6 IL1B IL10 CXCL8
49 placenta disease 30.0 TNF TLR4 IL6 IL1B CXCL8 CRP
50 chorioamnionitis 30.0 TNF TLR4 IL6 IL1B IL10 CXCL8

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to Perinatal Necrotizing Enterocolitis

Symptoms & Phenotypes for Perinatal Necrotizing Enterocolitis

Human phenotypes related to Perinatal Necrotizing Enterocolitis:

58 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 vomiting 58 Occasional (29-5%)
2 edema 58 Occasional (29-5%)
3 ascites 58 Occasional (29-5%)
4 thrombocytopenia 58 Occasional (29-5%)
5 increased serum lactate 58 Occasional (29-5%)
6 hyponatremia 58 Frequent (79-30%)
7 apnea 58 Occasional (29-5%)
8 neutropenia 58 Frequent (79-30%)
9 premature birth 58 Very frequent (99-80%)
10 lethargy 58 Occasional (29-5%)
11 metabolic acidosis 58 Occasional (29-5%)
12 abnormal heart morphology 58 Occasional (29-5%)
13 hypotension 58 Occasional (29-5%)
14 diarrhea 58 Frequent (79-30%)
15 small for gestational age 58 Frequent (79-30%)
16 gastroschisis 58 Occasional (29-5%)
17 abdominal distention 58 Frequent (79-30%)
18 peritonitis 58 Occasional (29-5%)
19 leukocytosis 58 Frequent (79-30%)
20 hyperglycemia 58 Occasional (29-5%)
21 disseminated intravascular coagulation 58 Occasional (29-5%)
22 temperature instability 58 Occasional (29-5%)
23 acidosis 58 Occasional (29-5%)
24 food intolerance 58 Frequent (79-30%)
25 bradycardia 58 Occasional (29-5%)
26 bloody diarrhea 58 Frequent (79-30%)
27 neonatal sepsis 58 Occasional (29-5%)
28 shock 58 Occasional (29-5%)
29 abnormal glucose homeostasis 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 CCR6 CPVL CRP FABP2 HBEGF IL10
2 immune system MP:0005387 10.03 CCR6 CPVL CRP EGF IL10 IL1B
3 digestive/alimentary MP:0005381 9.92 EGF IL10 IL6 OCLN TLR2 TLR4
4 integument MP:0010771 9.61 CPVL EGF HBEGF IL10 IL1B IL6
5 neoplasm MP:0002006 9.17 IL10 IL1B IL6 LTF TLR2 TLR4

Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

Drugs for Perinatal Necrotizing Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 220)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Histamine Approved, Investigational Phase 4 51-45-6 774
4
Famotidine Approved Phase 4 76824-35-6 3325
5
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
6
Zinc Approved, Investigational Phase 4 7440-66-6 32051
7
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
8 Beractant Approved Phase 4 108778-82-1
9 Poractant alfa Approved Phase 4 129069-19-8
10
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
11 Coconut Approved Phase 4
12
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
13
Sorbitol Approved Phase 4 50-70-4 5780
14
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
15
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
16
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
17
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
18
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
19 Tocotrienol Investigational Phase 4 6829-55-6
20 Immunologic Factors Phase 4
21 Immunoglobulins Phase 4
22 Antibodies Phase 4
23 Immunoglobulins, Intravenous Phase 4
24 Rho(D) Immune Globulin Phase 4
25 gamma-Globulins Phase 4
26 Antioxidants Phase 4
27 Protective Agents Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29 Carotenoids Phase 4
30
Picolinic acid Phase 4 98-98-6 1018
31 Provitamins Phase 4
32 Chelating Agents Phase 4
33 Iron Chelating Agents Phase 4
34 Calciferol Phase 4
35 Antacids Phase 4
36 Anti-Ulcer Agents Phase 4
37 Histamine Antagonists Phase 4
38 Histamine H2 Antagonists Phase 4
39
Histamine Phosphate Phase 4 51-74-1 65513
40 Pharmaceutical Solutions Phase 4
41 Vitamins Phase 4
42 Gentamicins Phase 4
43 Dermatologic Agents Phase 4
44 Anti-Inflammatory Agents Phase 4
45 Gastrointestinal Agents Phase 4
46 Hormones Phase 4
47 Hormone Antagonists Phase 4
48 glucocorticoids Phase 4
49 Respiratory System Agents Phase 4
50 Pulmonary Surfactants Phase 4

Interventional clinical trials:

(show top 50) (show all 345)
# Name Status NCT ID Phase Drugs
1 The Effect of Withholding Feeds During Red Blood Cell Transfusion on Development of TRAGI in Very Low Birth Weight Infants Unknown status NCT02132819 Phase 4
2 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of Inflammation Unknown status NCT01765998 Phase 4 Probiotic;Placebo
3 THE EFFECT OF SUSTAINED LUNG INFLATION MANEUVER APPLIED THROUGH NASAL PRONG ON EARLY AND LATE RESPIRATORY MORBIDITIES IN PRETERM INFANTS Unknown status NCT02887924 Phase 4
4 Effect of Melatonin on Feeding Intolerance and Incidence of Necrotizing Enterocolitis in Preterm Infants Completed NCT04304807 Phase 4 Melatonin 20 mg;Traditional antibiotic treatment
5 Early Sodium Intake in Preterm Newborns; Randomized Clinical Trial Completed NCT04035564 Phase 4 Sodium < 1mEq/kg/day;Sodium 5mEq/kg/day
6 Systematic Randomized , Single Blinded, Placebo-Controlled Trial of Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
7 Randomized Evaluation of the Use of Plastic Bags to Prevent Neonatal Hypothermia in Developing Countries-Part IV Completed NCT01604447 Phase 4
8 A Randomized Trial to Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates in Developing Countries Completed NCT01403623 Phase 4
9 A Randomized Double-Blinded Study Comparing the Impact of One Versus Two Courses of Antenatal Steroids on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
10 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
11 Phase 4 Study of Use of High-dose Intravenous Immune Globulin for Prevent Hyperbilirubinemia Due Rh Hemolytic Disease in Newborns Infants Completed NCT00288600 Phase 4 Intravenous Immunoglobulin;Normal saline solution
12 The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
13 Stress Ulcer Prophylaxis Versus Placebo - a Blinded Randomized Control Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease Recruiting NCT03667703 Phase 4 Famotidine;Placebo
14 Oral Zinc Supplementation Improving Growth and Reducing Morbidity on Very Low Birth Weight Infant Not yet recruiting NCT04050488 Phase 4 Zinc Sulfate;Placebos
15 NICU Antibiotics and Outcomes Trial Not yet recruiting NCT03997266 Phase 4 Ampicillin;Gentamycin;Normal saline
16 Personalized Versus Standardized Parenteral Nutrition for Preterm Infants With a Birth Weight Greater Than 1250 Grams: a Multicenter Randomized Phase IV Clinical Trial Not yet recruiting NCT03693287 Phase 4 Standardized-parenteral nutrition (S-PN);Personalized-parenteral nutrition (P-PN)
17 Impact of Early Postnatal Sodium Supplementation on Weight Gain in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4 Sodium chloride;Placebo
18 Phase 4 Study of Curosurf (Poractant) and Survanta (Beractant) Surfactant Treatment in Very Premature Infants With Respiratory Distress Syndrome. Terminated NCT00767039 Phase 4 Survanta (beractant);Curosurf (poractant)
19 Effects of the Use of a Bottle and a Cup on Breast Sucking Patterns of Premature Infants: Safety and Efficacy Terminated NCT00703950 Phase 4
20 Incidence and Severity of Parenteral Nutrition Associated Cholestasis in Neonates Subjected to Major Surgery, Using Two Mixed Intravenous Lipid Emulsions Terminated NCT02633384 Phase 4
21 Randomized Trial on Efficacy and Safety of the Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth (ACG Trial) Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)
22 A Pilot Study to Compare the Use of Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Withdrawn NCT02774317 Phase 4
23 Role Of Saccharomyces Boulardii in Preventin Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3 Saccharomyces boulardii;Placebo
24 Effect of Cysteine Supplementation on Glutathione Production in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
25 Efficacy and Safety of Probiotics in Neonatal Hyperbilirubinemia Unknown status NCT03266913 Phase 3 Probiotic
26 Nasal Intermittent Mandatory Ventilation Versus Continuous Positive Airway Pressure After Extubation of Very Low Birth Weight Infants of the NEOCOSUR Network. Unknown status NCT01778829 Phase 3
27 Role Of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis in Very Low Birth Weight Infants Completed NCT01531179 Phase 3 Lactobacillus reuteri;Placebo
28 Role of Probiotics for Prevention of Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants: A Double Blind Randomized Controlled Trial Completed NCT02650869 Phase 3
29 Effect of Vitamin A in the Treatment of Sepsis and Necrotizing Enterocolitis in Hospitalized Neonates Completed NCT00707785 Phase 3
30 Nosocomial Infections and Necrotizing Enterocolitis in Preterm Neonates Treated With Lactobacillus Acidophilus and Bifidobacterium Infantis in An Intensive Care Unit : A Randomized Controlled Study Completed NCT01340469 Phase 3
31 The Efficacy of Symbiotic Preparation on Cytokines Which Act on Necrotising Enterocolitis Pathogenesis in Very Low Birth Weight Infants Completed NCT01899677 Phase 3 symbiotic
32 The Use of Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature and Very-low Birth Weight Infants Completed NCT01868737 Phase 3
33 Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) Completed NCT00009646 Phase 3 indomethacin;Indomethacin;Placebo
34 Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth Completed NCT02350231 Phase 2, Phase 3 The progesterone vaginal pessary;Tonics group
35 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
36 Pentoxifylline Therapy of Late-onset Sepsis in Preterm Infants: A Randomized Controlled Trial. Completed NCT02163174 Phase 3 Pentoxifylline (PTX);Placebo
37 A Single Blinded Study on the Effect of Saccharomyces Boulardii CNCM I-745 on Growth and Development in Preterm Infants Completed NCT02310425 Phase 3 S. boulardii;Placebo
38 Decreasing Rates of Illnesses in Kids (DRINK) Completed NCT00356382 Phase 3 Lactobacillus (L.) casei
39 Inhaled NO in Prevention of Chronic Lung Disease Completed NCT00000548 Phase 3
40 Early Vitamin D Supplementation for Prevention of Respiratory Morbidity in Extremely Preterm Infants: A Randomized Clinical Trial Completed NCT01600430 Phase 2, Phase 3
41 Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy/Safety of CY-1503 (Cylexin) in Prevention of Reperfusion Injury in Neonates/Infants Undergoing Hypothermic Cardiopulmonary Bypass Completed NCT00226369 Phase 2, Phase 3 CY-1503
42 Comparison of Intravenous Ibuprofen vs. Continuous Indomethacin in the Treatment of Patent Ductus Arteriosus Completed NCT00485160 Phase 3 Continuous indomethacin;ibuprofen
43 Randomized Clinical Trial of Dexamethasone Therapy in Very-Low-Birth-Weight Infants at Risk for Chronic Lung Disease (CLD) Completed NCT00011362 Phase 3 Dexamethasone Early;Dexamethasone Late
44 Effect of Early Enteral Supplementation of L-arginine and Glutamine on Preterm Neonate Completed NCT01263041 Phase 2, Phase 3 Glutamine;l-arginine
45 A Randomized Controlled Trial on the Effectiveness of Inhaled Nitrous Oxide for Pain Relief During ROP Screening Exam in the Pre-term Infant Completed NCT00623220 Phase 3
46 High-dose Ibuprofen for Patent Ductus Arteriosus in Extremely Preterm Infants: a Randomized Controlled Study Completed NCT01243996 Phase 2, Phase 3 Ibuprofen
47 A Randomized, Double Blind, Parallel-group, Placebo Controlled Study to Evaluate the Efficacy and Safety of IBP-9414 in Premature Infants 500-1500g Birth Weight in the Prevention of Necrotizing Enterocolitis - The Connection Study Recruiting NCT03978000 Phase 3 IBP-9414;Placebo
48 Nordic Study on Human Milk Fortification in Extremely Preterm Infants: a Randomized Controlled Trial Recruiting NCT03797157 Phase 2, Phase 3
49 Can Bovine Lactoferrin Prevent Neonatal Infections in Low Birth Weight Babies in Karachi, Sindh, Pakistan. Recruiting NCT03431558 Phase 3 Glucon-D 99.4% (Placebo)
50 Phase III Clinical Trial, Randomized, Multicentre, Double Blind to Evaluate Two Guidelines for the Administration of Ibuprofen in the Treatment of Persistent Ductus Arteriosus Eco-guided: Impact in the Intestinal Prognosis Recruiting NCT04282941 Phase 3 Ibuprofen in continuous (24 hours) iv infusion and EchoG;IV bolus Ibuprofen slow (15 minutes) and EchoG

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Cochrane evidence based reviews: enterocolitis, necrotizing

Genetic Tests for Perinatal Necrotizing Enterocolitis

Anatomical Context for Perinatal Necrotizing Enterocolitis

MalaCards organs/tissues related to Perinatal Necrotizing Enterocolitis:

40
Colon, Breast, Heart, Lung, Liver, Brain, Neutrophil

Publications for Perinatal Necrotizing Enterocolitis

Articles related to Perinatal Necrotizing Enterocolitis:

(show top 50) (show all 6707)
# Title Authors PMID Year
1
Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis. 54 61
20485148 2010
2
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. 54 61
20464748 2010
3
A systematic review of serologic tests in the diagnosis of necrotizing enterocolitis. 54 61
19944232 2009
4
Heat susceptibility of interleukin-10 and other cytokines in donor human milk. 54 61
19366315 2009
5
Heparin-binding EGF-like growth factor is a potent dilator of terminal mesenteric arterioles. 61 54
19389413 2009
6
Can lactoferrin prevent neonatal sepsis and necrotizing enterocolitis? 54 61
19485792 2009
7
Preclinical neonatal rat studies of heparin-binding EGF-like growth factor in protection of the intestines from necrotizing enterocolitis. 61 54
19127210 2009
8
Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates. 54 61
19160324 2009
9
Effects of sepsis on neonatal thrombopoiesis. 54 61
18552713 2008
10
Heparin-binding epidermal growth factor-like growth factor gene disruption is associated with delayed intestinal restitution, impaired angiogenesis, and poor survival after intestinal ischemia in mice. 54 61
18558204 2008
11
Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis. 61 54
18346534 2008
12
Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation. 61 54
18239063 2008
13
Tissue distribution and plasma clearance of heparin-binding EGF-like growth factor (HB-EGF) in adult and newborn rats. 61 54
16364500 2006
14
Heparin-binding EGF-like growth factor (HB-EGF) and necrotizing enterocolitis. 54 61
16084404 2005
15
Lactoferrin-enhanced anoikis: a defense against neonatal necrotizing enterocolitis. 61 54
15950395 2005
16
Epidermal growth factor and necrotizing enterocolitis. 61 54
15183666 2004
17
Heparin-binding epidermal growth factor-like growth factor and intestinal ischemia-reperfusion injury. 61 54
14765365 2004
18
Intraluminal casein model of necrotizing enterocolitis for assessment of mucosal destruction, bacterial translocation, and the effects of allopurinol and N-acetylcysteine. 61 54
12598971 2002
19
Diminished epidermal growth factor levels in infants with necrotizing enterocolitis. 61 54
10693661 2000
20
Klebsiella pneumoniae with extended spectrum beta-lactamase activity associated with a necrotizing enterocolitis outbreak. 54 61
10571430 1999
21
Plasma intestinal fatty acid binding protein in neonates with necrotizing enterocolitis: a pilot study. 61 54
10549746 1999
22
Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation. 54 61
10483903 1999
23
The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis. 61 54
9396557 1997
24
Clinical applications of epidermal growth factor. 54 61
8590139 1995
25
Presence of platelet-activating factor-acetylhydrolase in milk. 54 61
8228643 1993
26
Effect of necrotizing enterocolitis on urinary epidermal growth factor levels. 54 61
2058613 1991
27
Cytotoxin-producing Klebsiella oxytoca in the preterm gut and its association with necrotizing enterocolitis. 61
32525754 2020
28
A randomized controlled trial comparing the effect of fortification of human milk with an infant formula powder versus unfortified human milk on the growth of preterm very low birth weight infants. 61
30486700 2020
29
The effects of latency period in PPROM cases managed expectantly. 61
32089027 2020
30
Outcomes in preterm small versus appropriate for gestation infants after Bifidobacterium breve M-16 V supplementation. 61
30394171 2020
31
Incidence, risk factors, and outcomes of acute kidney injury in neonates after surgical procedures. 61
32232634 2020
32
The Role of Human Coronavirus Infection in Pediatric Acute Gastroenteritis. 61
32433226 2020
33
Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis. 61
32319640 2020
34
Novel useful markers for follow-up of necrotizing enterocolitis: endocan and interleukin-33. 61
30431380 2020
35
Reduced fetal movements at term in singleton low risk pregnancies-Is there an association with placental histopathological findings? 61
31960411 2020
36
Less invasive surfactant administration versus endotracheal surfactant instillation followed by limited peak pressure ventilation in preterm infants with respiratory distress syndrome in China: study protocol for a randomized controlled trial. 61
32527290 2020
37
Intracerebral large artery disease in Aicardi-Goutières syndrome with TREX1 mutation: a case report. 61
32524323 2020
38
Asymmetric retinopathy of prematurity in presumed fungal endophthalmitis. 61
32382688 2020
39
Survival Without Major Morbidity Among Very Low Birth Weight Infants in California. 61
32554813 2020
40
Outcomes of truncus arteriosus repair and predictors of mortality. 61
32557823 2020
41
Neutrophil extracellular trap inhibition increases inflammation, bacteraemia and mortality in murine necrotizing enterocolitis. 61
32515131 2020
42
Transperineal Intracath Meconiolysis and Evacuation Technique of "Distended" Bowel Evacuation for One-Stage Laparoscopic Anorectoplasty for High Anorectal Malformations in Males. 61
32216702 2020
43
Impact of Early-Onset Sepsis and Antibiotic Use on Death or Survival with Neurodevelopmental Impairment at 2 Years of Age among Extremely Preterm Infants. 61
32446491 2020
44
Chyme recycling in the management of small bowel double enterostomy in pediatric and neonatal populations: A systematic review. 61
32359729 2020
45
Antenatal Corticosteroids and Outcomes in Preterm Twins. 61
32459431 2020
46
Beneficial effects of butyrate in intestinal injury. 61
32234318 2020
47
Surgical ligation of patent ductus arteriosus in preterm neonates weighing less than 1500g: a 9-year single center experience. 61
32552772 2020
48
Preventative and therapeutic effects of fennel (Foeniculum vulgare) seed extracts against necrotizing enterocolitis. 61
32510653 2020
49
Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants: Neomune-NeoNutriNet Cohort Study. 61
32553865 2020
50
[Ready-to-use parenteral nutrition in a preterm infant with necrotizing enterocolitis and related complications: case report]. 61
32573561 2020

Variations for Perinatal Necrotizing Enterocolitis

Expression for Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for Perinatal Necrotizing Enterocolitis

Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 TNF TLR9 TLR4 TLR2 LTF IL6
2
Show member pathways
13.86 TNF THPO IL6 IL1B IL10 HBEGF
3
Show member pathways
13.45 TNF TLR9 TLR4 TLR2 THPO IL6
4
Show member pathways
13.39 TNF IL6 IL1B IL10 HBEGF EGF
5
Show member pathways
13.37 TNF THPO PLA2G7 IL6 IL1B IL10
6
Show member pathways
13.26 TNF TLR9 TLR4 TLR2 IL1B HBEGF
7
Show member pathways
13.04 TNF TLR9 TLR4 TLR2 OCLN IL6
8
Show member pathways
12.99 TNF TLR4 TLR2 IL6 IL1B CXCL8
9
Show member pathways
12.91 TNF TLR9 TLR4 TLR2 IL6 IL1B
10
Show member pathways
12.88 TNF IL6 IL1B IL10 CXCL8
11 12.82 TNF TLR9 TLR2 IL6 IL1B
12
Show member pathways
12.82 TNF TLR9 TLR4 TLR2 IL6 IL1B
13
Show member pathways
12.78 TNF TLR9 TLR4 TLR2 THPO IL6
14
Show member pathways
12.69 TNF TLR4 TLR2 IL6 IL1B IL10
15
Show member pathways
12.65 TNF TLR9 TLR4 TLR2 IL1B
16
Show member pathways
12.65 TNF TLR9 TLR4 TLR2 IL6 IL1B
17 12.63 TNF TLR9 TLR2 IL1B IL10
18
Show member pathways
12.43 TNF TLR2 IL6 IL1B CXCL8
19 12.42 TNF TLR4 IL1B CXCL8
20
Show member pathways
12.42 TNF IL6 IL10 CXCL8 CCR6
21
Show member pathways
12.4 TNF TLR4 IL6 IL1B CXCL8
22 12.39 TNF TLR4 OCLN IL6 IL1B CXCL8
23
Show member pathways
12.38 TNF TLR9 TLR4 TLR2 IL6 CXCL8
24 12.38 TNF TLR9 TLR4 TLR2 IL6 IL1B
25
Show member pathways
12.37 TNF THPO IL6 IL1B IL10 HBEGF
26
Show member pathways
12.36 TNF IL6 IL1B CRP
27
Show member pathways
12.36 TNF TLR4 TLR2 IL1B IL10
28 12.34 TNF TLR4 TLR2 HBEGF
29 12.33 TNF TLR4 IL6 IL1B CXCL8
30
Show member pathways
12.31 TNF TLR9 IL6 IL1B IL10
31 12.29 TNF TLR9 TLR4 TLR2 IL6 EGF
32 12.27 TNF IL6 IL1B IL10 CXCL8
33 12.2 TNF TLR9 TLR4 TLR2 IL6 IL1B
34 12.13 TNF TLR4 IL6 IL1B CXCL8
35
Show member pathways
12.13 TNF TLR9 TLR4 TLR2 IL6 IL1B
36
Show member pathways
12.11 TLR9 TLR4 TLR2 IL1B
37 12.1 TNF IL6 IL1B IL10 CXCL8
38 12.09 TNF TLR4 IL6 IL1B IL10 CXCL8
39 12.07 TNF THPO IL6 IL10
40 12.02 TNF TLR4 IL1B CXCL8
41 12 TNF IL6 IL1B CXCL8
42 11.99 TNF THPO IL6 IL1B
43
Show member pathways
11.99 TLR9 TLR4 TLR2 IL6 IL1B
44 11.97 THPO IL6 HBEGF EGF
45 11.92 TNF TLR4 TLR2 IL6 IL1B CXCL8
46 11.89 TNF IL1B IL10 CCR6
47 11.87 TNF TLR9 IL6 IL1B IL10
48 11.77 HBEGF EGF CXCL8
49
Show member pathways
11.77 TNF IL6 IL1B CXCL8
50 11.77 TNF IL6 IL1B EGF CXCL8

GO Terms for Perinatal Necrotizing Enterocolitis

Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF TLR9 THPO PLA2G7 LTF IL6
2 cell surface GO:0009986 9.7 TNF TLR4 TLR2 LTF HBEGF GOT2
3 extracellular space GO:0005615 9.4 TNF THPO PLA2G7 LTF IL6 IL1B

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.3 TLR9 TLR4 TLR2 THPO IL6 IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.28 TNF TLR9 TLR4 TLR2 IL6 IL1B
3 negative regulation of cell proliferation GO:0008285 10.14 TLR2 IL6 IL1B IL10 CXCL8
4 cytokine-mediated signaling pathway GO:0019221 10.09 TNF IL6 IL1B IL10 CXCL8
5 defense response to bacterium GO:0042742 10.06 TNF TLR9 TLR4 LTF IL10
6 inflammatory response GO:0006954 10.06 TNF TLR9 TLR4 TLR2 IL6 IL1B
7 positive regulation of protein kinase B signaling GO:0051897 10.02 TNF THPO HBEGF EGF
8 response to lipopolysaccharide GO:0032496 10.02 TLR4 TLR2 IL1B IL10
9 immune response GO:0006955 10.02 TNF TLR9 TLR4 TLR2 IL6 IL1B
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.01 TNF TLR9 TLR4 LTF IL1B
11 activation of MAPK activity GO:0000187 9.99 TNF TLR4 IL1B EGF
12 positive regulation of MAPK cascade GO:0043410 9.98 TLR9 THPO IL6 EGF
13 positive regulation of DNA-binding transcription factor activity GO:0051091 9.97 TNF IL6 IL1B IL10
14 defense response to Gram-positive bacterium GO:0050830 9.97 TNF TLR2 IL6 CRP
15 cellular response to lipopolysaccharide GO:0071222 9.97 TNF TLR4 IL6 IL1B IL10 CXCL8
16 positive regulation of gene expression GO:0010628 9.97 TNF TLR9 TLR4 TLR2 OCLN IL6
17 defense response to Gram-negative bacterium GO:0050829 9.93 TLR9 TLR4 LTF IL6
18 positive regulation of JNK cascade GO:0046330 9.93 TNF TLR9 TLR4 IL1B
19 response to insulin GO:0032868 9.92 TLR2 IL10 GOT2
20 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.91 TNF TLR9 TLR4
21 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL10
22 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 TNF IL6 HBEGF
23 positive regulation of tumor necrosis factor production GO:0032760 9.89 TLR9 TLR4 TLR2
24 positive regulation of interferon-gamma production GO:0032729 9.88 TNF TLR4 IL1B
25 toll-like receptor signaling pathway GO:0002224 9.88 TLR9 TLR4 TLR2
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF TLR4 IL1B
27 humoral immune response GO:0006959 9.88 TNF LTF IL6 CCR6
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TNF TLR9 TLR4 TLR2 IL1B
29 positive regulation of inflammatory response GO:0050729 9.88 TNF TLR9 TLR4 TLR2 PLA2G7 IL1B
30 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.85 TLR9 TLR4 TLR2
31 positive regulation of JAK-STAT cascade GO:0046427 9.85 TNF IL6 IL10
32 negative regulation of neurogenesis GO:0050768 9.84 TNF IL6 IL1B
33 positive regulation of interleukin-6 secretion GO:2000778 9.84 TNF TLR4 TLR2 IL1B
34 positive regulation of interferon-beta production GO:0032728 9.83 TLR9 TLR4 TLR2
35 negative regulation of interleukin-6 production GO:0032715 9.83 TNF TLR9 TLR4 IL10
36 positive regulation of interleukin-12 production GO:0032735 9.82 TLR9 TLR4 TLR2
37 positive regulation of interleukin-10 production GO:0032733 9.82 TLR9 TLR4 TLR2
38 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.81 TNF TLR4 IL6
39 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF TLR4 TLR2 IL1B
40 positive regulation of glial cell proliferation GO:0060252 9.8 TNF IL6 IL1B
41 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TNF TLR9 TLR4 TLR2 LTF IL6
42 positive regulation of interleukin-8 secretion GO:2000484 9.79 TNF TLR4 TLR2
43 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.78 TNF IL1B IL10
44 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.77 TLR9 TLR4 TLR2
45 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.77 TNF TLR9 TLR4
46 positive regulation of neuroinflammatory response GO:0150078 9.75 TNF IL6 IL1B
47 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 TLR9 IL1B
48 cellular response to lipoteichoic acid GO:0071223 9.74 TLR4 TLR2
49 positive regulation of MHC class II biosynthetic process GO:0045348 9.74 TLR4 IL10
50 negative regulation of interleukin-8 production GO:0032717 9.74 TLR9 IL10

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 THPO IL6 IL10 HBEGF EGF
2 lipopolysaccharide binding GO:0001530 9.33 TLR4 TLR2 LTF
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
4 cytokine activity GO:0005125 9.1 TNF THPO IL6 IL1B IL10 CXCL8

Sources for Perinatal Necrotizing Enterocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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