MCID: PRN007
MIFTS: 37

Perinephritis

Categories: Nephrological diseases

Aliases & Classifications for Perinephritis

MalaCards integrated aliases for Perinephritis:

Name: Perinephritis 12 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2982
MeSH 45 D010501
UMLS 74 C0031065

Summaries for Perinephritis

MalaCards based summary : Perinephritis is related to autosomal dominant polycystic kidney disease and tempi syndrome. An important gene associated with Perinephritis is ADRA2C (Adrenoceptor Alpha 2C), and among its related pathways/superpathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Affiliated tissues include kidney, smooth muscle and colon, and related phenotypes are Decreased substrate adherent cell growth and cardiovascular system

Related Diseases for Perinephritis

Diseases related to Perinephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 autosomal dominant polycystic kidney disease 29.5 EDN1 EDNRA EDNRB REN
2 tempi syndrome 11.9
3 pyelonephritis 10.3
4 ocular hypotension 10.3 ADRB1 ADRB2
5 horner's syndrome 10.3 ADRA1A ADRA2A
6 meningococcal infection 10.3 ADRB1 ADRB2
7 malignant hypertensive renal disease 10.2 EDN1 REN
8 malignant renovascular hypertension 10.2 EDN1 REN
9 renal cell carcinoma, nonpapillary 10.2
10 malignant secondary hypertension 10.2 EDN1 REN
11 polyarteritis nodosa 10.2
12 resting heart rate, variation in 10.2 ADRA2B ADRB1 ADRB2
13 raynaud phenomenon 10.2 ADRA2C EDN1
14 angiomyolipoma 10.2
15 malignant hypertension 10.1 EDN1 REN
16 benign essential hypertension 10.1 MGAM REN
17 mandibulofacial dysostosis with alopecia 10.1 EDN1 EDNRA
18 renal tuberculosis 10.1 EDN1 REN
19 xanthogranulomatous pyelonephritis 10.1
20 bullous impetigo 10.1 EDNRA EDNRB
21 hepatorenal syndrome 10.1 EDN1 REN
22 ritter's disease 10.1 EDNRA EDNRB
23 scarlet fever 10.1 EDNRA EDNRB
24 renal hypertension 10.1 EDN1 REN
25 aortic coarctation 10.1 ADRB1 ADRB2 EDN1
26 hydronephrosis 10.1
27 clear cell renal cell carcinoma 10.1
28 radiation proctitis 10.1 EDNRA EDNRB
29 coronary artery anomaly 10.0 ADRB1 ADRB2 EDN1
30 acute poststreptococcal glomerulonephritis 10.0 EDN1 EDNRB
31 liposarcoma 10.0
32 ureteral obstruction 10.0
33 adenoma 10.0
34 kidney angiomyolipoma 10.0
35 coronary artery vasospasm 10.0 EDN1 MGAM
36 persistent fetal circulation syndrome 10.0 EDN1 EDNRA
37 space motion sickness 9.9 MGAM REN
38 oncocytoma 9.9
39 nephrolithiasis 9.9
40 renal oncocytoma 9.9
41 lymphoma 9.9
42 neurogenic bladder 9.9
43 ureterolithiasis 9.9
44 splenic abscess 9.9
45 cystic kidney disease 9.9
46 kidney disease 9.9
47 acute pyelonephritis 9.9
48 appendicitis 9.9
49 polycystic kidney disease 9.9
50 lymphangiomatosis 9.9

Graphical network of the top 20 diseases related to Perinephritis:



Diseases related to Perinephritis

Symptoms & Phenotypes for Perinephritis

GenomeRNAi Phenotypes related to Perinephritis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.92 ADRA1A ADRA1B ADRA1D ADRA2B

MGI Mouse Phenotypes related to Perinephritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
2 behavior/neurological MP:0005386 10.2 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
3 homeostasis/metabolism MP:0005376 10.13 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB1
4 growth/size/body region MP:0005378 10.02 ADRA1B ADRA2B ADRB1 ADRB2 ADRB3 EDN1
5 mortality/aging MP:0010768 9.96 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB1
6 endocrine/exocrine gland MP:0005379 9.95 ADRA1B ADRB1 ADRB2 ADRB3 EDN1 EDNRA
7 muscle MP:0005369 9.85 ADRA1A ADRA1B ADRA1D ADRA2B ADRB1 ADRB2
8 nervous system MP:0003631 9.61 ADRA1B ADRA1D ADRA2A ADRA2C ADRB2 EDN1
9 renal/urinary system MP:0005367 9.17 ADRA1A ADRA1B ADRA2B EDN1 EDNRA EDNRB

Drugs & Therapeutics for Perinephritis

Search Clinical Trials , NIH Clinical Center for Perinephritis

Cochrane evidence based reviews: perinephritis

Genetic Tests for Perinephritis

Anatomical Context for Perinephritis

MalaCards organs/tissues related to Perinephritis:

42
Kidney, Smooth Muscle, Colon, Skeletal Muscle, B Cells, Cortex

Publications for Perinephritis

Articles related to Perinephritis:

(show all 41)
# Title Authors Year
1
Bilateral xanthogranulomatous perinephritis without renal parenchymal involvement. ( 10879698 )
2000
2
Page kidney with constrictive perinephritis. ( 8341012 )
1993
3
Effects of endothelin upon blood pressure in normotensive rabbits and in perinephritis hypertension. ( 1325511 )
1992
4
Noradrenaline and endothelin-stimulated inositol phosphate formation in arterial smooth muscle from rabbits with perinephritis hypertension. ( 1794209 )
1991
5
Inositol phosphate formation in arterial smooth muscle from rabbits with perinephritis hypertension. ( 1962806 )
1990
6
Noradrenaline sensitivity and calcium fluxes in arteries from rabbits with perinephritis hypertension. ( 2208798 )
1990
7
Skeletal muscle beta 2-adrenoreceptors and the effect of adrenergic drugs on plasma potassium in perinephritis hypertension in rabbits. ( 2541134 )
1989
8
Platelet cytosolic free calcium before and after antihypertensive treatment in perinephritis hypertension of the rabbit. ( 2571432 )
1989
9
Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey): studies of the renin-angiotensin-aldosterone axis and renal hemodynamic function. ( 2677140 )
1989
10
Desensitization of vascular and platelet alpha 2-adrenoceptors in rabbits with perinephritis hypertension. ( 2897989 )
1988
11
Electrophysiological properties of the mesenteric artery of the rabbit with perinephritis hypertension. ( 3390614 )
1988
12
45Ca uptake and the actions of Bay K 8644 on aortic strips from rabbits with perinephritis hypertension. ( 2448370 )
1987
13
Perisplenitis and perinephritis in the Curtis-Fitz-Hugh syndrome. ( 3815024 )
1987
14
Alterations of the glomerular beta-adrenoceptor-linked adenylate cyclase system in perinephritis hypertension. ( 2419695 )
1986
15
Cardiac and lymphocyte beta-adrenoceptors in perinephritis hypertension in the rabbit. ( 2425174 )
1986
16
Studies on alpha 2-adrenoceptors in rabbits with perinephritis hypertension. ( 2870119 )
1986
17
Systemic and regional haemodynamic profile of captopril in conscious rabbits with bilateral cellophane perinephritis hypertension. ( 3912085 )
1985
18
Xanthogranulomatous perinephritis: unusual cause of renal vein and vena caval thrombosis. ( 3984116 )
1985
19
Alpha adrenoceptors and autonomic mechanisms in perinephritis hypertension in the rabbit. ( 6317553 )
1983
20
Systemic and regional hemodynamic characteristics of bilateral cellophane perinephritis hypertension in conscious rabbits. ( 6883748 )
1983
21
Serum angiotensin converting enzyme activity and the capacity to develop hypertention-associated arterial disease. Studies during the induction phase of one-kidney perinephritis hypertension in rabbits. ( 213977 )
1978
22
Hemodynamic effects of an angiotensin II antagonist in rabbits with perinephritis hypertension. ( 866354 )
1977
23
Perinephritis hypertension in monkeys. I. An increase of plasma renin activity associated with increased permeability of retinal vessels and angionecrosis. ( 6807 )
1976
24
Role of the renin-angiotensin system in dogs with perinephritis hypertension. ( 967886 )
1976
25
Colonic changes secondary to left perinephritis: new observations. ( 4828982 )
1974
26
Increased serum cholesterol and non-esterified fatty acid levels in rats with constrictive perinephritis and maintained on normal diet. ( 4841653 )
1974
27
Cellophane perinephritis hypertension and its reversal in rabbits. Effect on plasma renin, renin substrate, and renal mass. ( 4358201 )
1973
28
Renal cortical abscess, perinephritis and perinephric abscess in diabetes. ( 4713176 )
1973
29
A case of perinephritis with renal artery stenosis and hypertension. ( 5654387 )
1968
30
Hypertension associated with traumatic perinephritis. ( 13988619 )
1963
31
Perinephritis plastica. ( 13234106 )
1955
32
Perinephritis plastica. ( 13216975 )
1954
33
II. Establishment of hypertension in rats; hypertension caused by perinephritis. ( 13002117 )
1952
34
Perinephritis and perinephric abscess; a study of 37 cases. ( 18135670 )
1949
35
Latex rubber capsule for producing hypertension in rats by perinephritis. ( 20239439 )
1947
36
Perinephritis with and without operation. ( 20247050 )
1946
37
Perinephritis and perirenal abscess. ( 20279545 )
1946
38
The pathological anatomy of cellophane perinephritis. ( 19970495 )
1940
39
Perinephritis - Suppurative and Nonsuppurative. ( 18742440 )
1933
40
Perinephritis. ( 18742659 )
1933
41
Acute Non-Suppurative Perinephritis. ( 20760378 )
1902

Variations for Perinephritis

Expression for Perinephritis

Search GEO for disease gene expression data for Perinephritis.

Pathways for Perinephritis

Pathways related to Perinephritis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
2
Show member pathways
13.44 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
3
Show member pathways
13.38 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
4
Show member pathways
12.85 ADRA1A ADRA1B ADRA1D ADRB1 ADRB2
5
Show member pathways
12.77 ADRA1A ADRA1B ADRA2A ADRA2B ADRB1 ADRB2
6
Show member pathways
12.55 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
7
Show member pathways
12.48 ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3
8
Show member pathways
12.41 ADRA2A ADRA2B ADRA2C ADRB2
9
Show member pathways
12.21 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
10
Show member pathways
12.17 ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3
11
Show member pathways
12.14 ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3
12 11.96 ADRB1 ADRB2 ADRB3
13
Show member pathways
11.87 ADRA1A ADRA1B ADRA1D
14 11.78 ADRA1D ADRB2 EDNRA
15
Show member pathways
11.76 ADRA2A ADRA2B ADRA2C
16 11.69 ADRB1 ADRB2 ADRB3 EDNRA REN
17
Show member pathways
11.65 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
18 11.57 ADRA1D ADRA2A ADRB1 ADRB2
19 11.49 ADRB1 ADRB2 ADRB3
20 11.47 EDN1 EDNRA EDNRB
21 11.33 ADRA1A ADRA1B ADRA2A ADRA2B ADRB1 ADRB2
22 11.3 ADRA1A ADRB1 EDN1 EDNRA EDNRB
23 11.21 EDN1 EDNRA EDNRB
24
Show member pathways
11.04 EDN1 EDNRA
25 10.59 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C

GO Terms for Perinephritis

Cellular components related to Perinephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.93 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
2 plasma membrane GO:0005886 9.77 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
3 integral component of plasma membrane GO:0005887 9.36 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
4 membrane GO:0016020 10.07 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C

Biological processes related to Perinephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.95 ADRA1A ADRA1B EDN1 EDNRA EDNRB
2 cell-cell signaling GO:0007267 9.95 ADRA1A ADRA1B ADRA1D ADRA2B ADRA2C EDN1
3 positive regulation of MAPK cascade GO:0043410 9.91 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB2
4 response to lipopolysaccharide GO:0032496 9.88 EDN1 EDNRB REN
5 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.88 ADRA2A ADRB1 ADRB2 ADRB3
6 platelet activation GO:0030168 9.86 ADRA2A ADRA2B ADRA2C
7 regulation of blood pressure GO:0008217 9.86 EDN1 EDNRA EDNRB REN
8 positive regulation of cold-induced thermogenesis GO:0120162 9.85 ADRB1 ADRB2 ADRB3
9 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.83 ADRA2A EDN1 EDNRA
10 activation of adenylate cyclase activity GO:0007190 9.83 ADRB1 ADRB2 ADRB3 EDNRA
11 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.82 ADRA1A ADRA1B EDNRB
12 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.81 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
13 activation of protein kinase B activity GO:0032148 9.8 ADRA2A ADRA2B ADRA2C
14 regulation of sensory perception of pain GO:0051930 9.8 ADRA2C EDN1 EDNRB
15 positive regulation of vasoconstriction GO:0045907 9.79 ADRA1A ADRA1B ADRA2C
16 positive regulation of smooth muscle contraction GO:0045987 9.75 ADRA1A ADRA1B EDN1
17 vasoconstriction GO:0042310 9.74 EDN1 EDNRA EDNRB
18 regulation of smooth muscle contraction GO:0006940 9.73 ADRA2A ADRA2B ADRA2C ADRB2
19 regulation of vasoconstriction GO:0019229 9.73 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C EDN1
20 activation of phospholipase C activity GO:0007202 9.71 ADRA1A EDNRA
21 branching involved in blood vessel morphogenesis GO:0001569 9.71 EDN1 EDNRA
22 brown fat cell differentiation GO:0050873 9.71 ADRB1 ADRB2
23 positive regulation of cardiac muscle hypertrophy GO:0010613 9.71 ADRA1A EDN1
24 negative regulation of norepinephrine secretion GO:0010700 9.71 ADRA2A ADRA2B ADRA2C
25 neural crest cell development GO:0014032 9.7 EDN1 EDNRA
26 positive regulation of heart rate GO:0010460 9.7 ADRA1A EDN1
27 regulation of cardiac muscle contraction GO:0055117 9.7 ADRA1A ADRA1B
28 regulation of pH GO:0006885 9.7 EDN1 EDNRB
29 regulation of muscle contraction GO:0006937 9.69 ADRA1A ADRA1B
30 smooth muscle contraction GO:0006939 9.69 ADRA1A EDNRA
31 negative regulation of epinephrine secretion GO:0032811 9.69 ADRA2A ADRA2B ADRA2C
32 positive regulation of renal sodium excretion GO:0035815 9.68 EDN1 EDNRB
33 positive regulation of urine volume GO:0035810 9.68 EDN1 EDNRB
34 enteric nervous system development GO:0048484 9.68 EDNRA EDNRB
35 negative regulation of multicellular organism growth GO:0040015 9.68 ADRB1 ADRB2
36 artery smooth muscle contraction GO:0014824 9.67 EDN1 EDNRA
37 diet induced thermogenesis GO:0002024 9.67 ADRB1 ADRB2
38 receptor transactivation GO:0035624 9.67 ADRA2A ADRA2B ADRA2C
39 regulation of glucose transmembrane transport GO:0010827 9.66 EDN1 EDNRA
40 epithelial fluid transport GO:0042045 9.65 EDN1 EDNRB
41 negative regulation of cellular protein metabolic process GO:0032269 9.65 EDN1 EDNRB
42 vein smooth muscle contraction GO:0014826 9.64 EDN1 EDNRB
43 desensitization of G protein-coupled receptor signaling pathway by arrestin GO:0002032 9.64 ADRB2 ADRB3
44 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 9.63 ADRA1A ADRA1B
45 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.63 ADRB1 ADRB2 ADRB3
46 endothelin receptor signaling pathway GO:0086100 9.61 EDNRA EDNRB
47 heat generation GO:0031649 9.61 ADRB1 ADRB2
48 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.61 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
49 positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 9.6 ADRA1A ADRB1
50 positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997 9.59 ADRA1A ADRB1

Molecular functions related to Perinephritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.91 ADRA1A ADRA1B ADRA2A ADRA2B ADRB1 ADRB2
2 protein heterodimerization activity GO:0046982 9.88 ADRA1A ADRA1B ADRA2A ADRA2C ADRB1
3 adrenergic receptor activity GO:0004935 9.61 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
4 alpha1-adrenergic receptor activity GO:0004937 9.54 ADRA1A ADRA1B ADRA1D
5 alpha2-adrenergic receptor activity GO:0004938 9.5 ADRA2A ADRA2B ADRA2C
6 alpha-2A adrenergic receptor binding GO:0031694 9.46 ADRA2C ADRB1
7 norepinephrine binding GO:0051380 9.46 ADRA2A ADRB1 ADRB2 ADRB3
8 beta-adrenergic receptor activity GO:0004939 9.43 ADRB1 ADRB3
9 endothelin receptor activity GO:0004962 9.4 EDNRA EDNRB
10 epinephrine binding GO:0051379 9.1 ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3
11 protein binding GO:0005515 10.34 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C

Sources for Perinephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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