MCID: PRN007
MIFTS: 38

Perinephritis

Categories: Nephrological diseases

Aliases & Classifications for Perinephritis

MalaCards integrated aliases for Perinephritis:

Name: Perinephritis 12 44 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2982
MeSH 44 D010501
SNOMED-CT 67 111404004
UMLS 71 C0031065

Summaries for Perinephritis

MalaCards based summary : Perinephritis is related to hypertension, essential and pulmonary arterial hypertension associated with connective tissue disease. An important gene associated with Perinephritis is REN (Renin), and among its related pathways/superpathways are PEDF Induced Signaling and p70S6K Signaling. The drugs Parathyroid hormone and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include kidney, colon and smooth muscle, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Perinephritis is an infection of the surroundings of the kidney either right or left. It can be the... more...

Related Diseases for Perinephritis

Diseases related to Perinephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 hypertension, essential 28.7 REN PRKCA PIK3C2A EDNRB EDNRA EDN1
2 pulmonary arterial hypertension associated with connective tissue disease 10.4 EDNRB EDNRA
3 bullous impetigo 10.3 EDNRB EDNRA
4 hypoaldosteronism 10.3 REN ACE
5 renal artery obstruction 10.3 REN ACE
6 radiation proctitis 10.3 EDNRB EDNRA
7 orthostatic proteinuria 10.3 REN ACE
8 femoral cancer 10.3 EDNRA EDN1
9 hypertension, diastolic 10.3 REN ACE
10 mandibulofacial dysostosis with alopecia 10.3 EDNRA EDN1
11 anhidrosis, isolated, with normal sweat glands 10.3 EDNRA EDN1
12 cholesterol embolism 10.3 REN ACE
13 generalized atherosclerosis 10.3 REN ACE
14 potter's syndrome 10.3 REN ACE
15 ritter's disease 10.3 EDNRB EDNRA
16 severe nonproliferative diabetic retinopathy 10.3 REN ACE
17 hypertensive retinopathy 10.3 REN ACE
18 kidney hypertrophy 10.3 REN ACE
19 nephrogenic systemic fibrosis 10.3 EDNRA EDN1
20 idiopathic edema 10.3 EDN1 ACE
21 fibromuscular dysplasia 10.3 REN ACE
22 idiopathic hypercalciuria 10.3 REN EDN1
23 malignant renovascular hypertension 10.3 REN EDNRA EDN1
24 malignant secondary hypertension 10.3 REN EDNRA EDN1
25 scarlet fever 10.3 EDNRB EDNRA
26 renal artery disease 10.2 REN ACE
27 acquired color blindness 10.2 EDNRB EDNRA EDN1
28 transient refractive change 10.2 EDNRB EDNRA EDN1
29 diffuse scleroderma 10.2 EDN1 ACE
30 hepatopulmonary syndrome 10.2 EDNRB EDNRA EDN1
31 pure autonomic failure 10.2 REN ACE
32 renovascular hypertension 10.2 REN EDN1 ACE
33 hypertensive encephalopathy 10.2 REN EDN1 ACE
34 kidney papillary necrosis 10.2 REN EDN1 ACE
35 pulmonary valve insufficiency 10.2 REN EDN1 ACE
36 benign essential hypertension 10.2 REN CYGB
37 tricuspid valve disease 10.2 REN EDN1 ACE
38 mitral valve stenosis 10.2 REN EDN1 ACE
39 inappropriate adh syndrome 10.2 REN ACE
40 hepatorenal syndrome 10.2 REN EDN1 ACE
41 malignant hypertension 10.2 REN EDN1 ACE
42 apnea, obstructive sleep 10.2 REN EDN1 ACE
43 sexual disorder 10.2 REN EDN1 ACE
44 renal hypertension 10.2 REN EDN1 ACE
45 oligohydramnios 10.2 REN EDN1 ACE
46 limited scleroderma 10.2 EDNRA EDN1 ACE
47 eclampsia 10.2 REN EDN1 ACE
48 background diabetic retinopathy 10.2 EDN1 ACE
49 patent ductus arteriosus 1 10.2 REN EDN1 ACE
50 diaphragmatic hernia, congenital 10.2 EDNRB EDNRA EDN1

Graphical network of the top 20 diseases related to Perinephritis:



Diseases related to Perinephritis

Symptoms & Phenotypes for Perinephritis

GenomeRNAi Phenotypes related to Perinephritis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.37 PIK3C2A
2 Decreased viability GR00055-A-2 10.37 PIK3C2A
3 Decreased viability GR00055-A-3 10.37 PIK3C2A MST1R
4 Decreased viability GR00107-A-1 10.37 PRKCA
5 Decreased viability GR00221-A-1 10.37 ALK PIK3C2A PRKCA MST1R ROS1
6 Decreased viability GR00221-A-2 10.37 PIK3C2A PRKCA TTN MST1R ROS1
7 Decreased viability GR00221-A-4 10.37 ALK PIK3C2A PRKCA TTN
8 Decreased viability GR00240-S-1 10.37 PIK3C2A
9 Decreased viability GR00249-S 10.37 ALK PIK3C2A PRKCA ROS1
10 Decreased viability GR00301-A 10.37 MST1R
11 Decreased viability GR00342-S-1 10.37 PIK3C2A PRKCA TTN ROS1
12 Decreased viability GR00342-S-2 10.37 PIK3C2A PRKCA ADRB2
13 Decreased viability GR00342-S-3 10.37 PIK3C2A PRKCA TTN ADRB2
14 Decreased viability GR00381-A-1 10.37 ADRB2
15 Decreased viability GR00381-A-3 10.37 ADRB2
16 Decreased viability GR00402-S-2 10.37 MST1R
17 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.13 ALK MST1R TTN

MGI Mouse Phenotypes related to Perinephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ACE ADRB2 CYGB EDN1 EDNRA EDNRB
2 homeostasis/metabolism MP:0005376 9.93 ACE ADRB2 ALK CYGB EDN1 EDNRA
3 endocrine/exocrine gland MP:0005379 9.86 ACE ADRB2 ALK CYGB EDN1 EDNRA
4 muscle MP:0005369 9.56 ADRB2 CYGB EDN1 EDNRA EDNRB PRKCA
5 renal/urinary system MP:0005367 9.17 ACE CYGB EDN1 EDNRA EDNRB PIK3C2A

Drugs & Therapeutics for Perinephritis

Drugs for Perinephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational 9002-64-6
2 Immunoglobulins
3 Antibodies
4 Anesthetics
5 Insulin, Globin Zinc
6 insulin
7 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Role of Immunohistochemical Markers , Geminin and Mcm2 in Prognosis of Renal Cell Carcinoma, and Its Clinicopathological Correlation. A Prospective Controlled Study Unknown status NCT03692533
2 The Physiology of Human Brown Adipose Tissue Recruiting NCT04352244
3 Comparative Effectiveness of Patient-Specific Simulated Rehearsal for Percutaneous Nephrolithotomy (PCNL) Recruiting NCT03272529
4 Prospective Study of Oncologic Outcomes After Laparoscopic Modified Complete Mesocolic Excision for Non-metastatic Right Colon Cancer [PIONEER Study]: Multicenter, Single-Arm Study Enrolling by invitation NCT03992599

Search NIH Clinical Center for Perinephritis

Cochrane evidence based reviews: perinephritis

Genetic Tests for Perinephritis

Anatomical Context for Perinephritis

MalaCards organs/tissues related to Perinephritis:

40
Kidney, Colon, Smooth Muscle, Skeletal Muscle

Publications for Perinephritis

Articles related to Perinephritis:

(show top 50) (show all 122)
# Title Authors PMID Year
1
Page Kidney Complicating Kidney Biopsy after Stopping Apixaban: A Physician's Dilemma. 61
33013072 2020
2
Post-Renal Biopsy Acute Kidney Injury and Page Kidney from Intra-Renal Hematoma Aggravated by Reversible Contrast-Induced Nephropathy Following Renal Arterial Embolization. 61
31964858 2020
3
Perinephric stranding and bulky psoas mimicking pyelonephritis in a case of non-Hodgkin lymphoma of kidney. 61
25813655 2015
4
The production process of "Étude sur le Rein des Urinaires", doctoral thesis of Joaquin María Albarrán at the Faculty of Medicine in Paris. 61
24210656 2014
5
[A case of renal arteriovenous fistula complicated with pyelonephritis]. 61
21832877 2011
6
Retroperitoneal perirenal pseudocyst in a Massese breed ram. 61
15945391 2005
7
[Xanthrogranulomatous pyelonephritis with nephrocutaneous fistula]. 61
12765065 2003
8
Apex-to-base dispersion of refractoriness underlies the proarrhythmic effect of hypokalaemia/hypomagnesaemia in the rabbit heart. 61
12122615 2002
9
Regional electrophysiological effects of left ventricular hypertrophy in isolated rabbit hearts under normal and ischaemic conditions. 61
11033114 2000
10
[Imaging of acute urinary infections in adults. Radiologic findings and strategy for imaging procedures]. 61
10995488 2000
11
Bilateral xanthogranulomatous perinephritis without renal parenchymal involvement. 61
10879698 2000
12
Hyperreninemic hypertension secondary to a subcapsular perinephric hematoma in a patient with polyarteritis nodosa. 61
9740170 1998
13
Laparoscopic nephrectomy: the experience of the laparoscopy working group of the German Urologic Association. 61
9628596 1998
14
Action potential prolongation and potassium currents in left-ventricular myocytes isolated from hypertrophied rabbit hearts. 61
9500863 1998
15
Development of severe secondary hypertension in a patient with systemic entomophthoromycosis. 61
9100054 1997
16
[Perinephritis--perinephric abscess, perirenal abscess]. 61
9278014 1997
17
Role of endogenous endothelin-1 in experimental renal hypertension in dogs. 61
7788903 1995
18
[Useful abdominal ultrasonography for diagnosis of Fitz-Hugh-Curtis syndrome: two case reports]. 61
7745311 1995
19
[Lumbar endoscopy: analysis and evaluation of 10 primary operations]. 61
7719361 1995
20
Effects of contraction-excitation feedback on electrophysiology and arrhythmogenesis in rabbits with experimental left ventricular hypertrophy. 61
7954651 1994
21
A characterized model of left ventricular hypertrophy in the rabbit. 61
7919055 1994
22
[Abscess of single kidney complicated by acute perinephritis and diffuse peritonitis]. 61
7823515 1994
23
Page kidney with constrictive perinephritis. 61
8341012 1993
24
Effects of endothelin upon blood pressure in normotensive rabbits and in perinephritis hypertension. 61
1325511 1992
25
Noradrenaline and endothelin-stimulated inositol phosphate formation in arterial smooth muscle from rabbits with perinephritis hypertension. 61
1794209 1991
26
Inositol phosphate formation in arterial smooth muscle from rabbits with perinephritis hypertension. 61
1962806 1990
27
[Chylous peritonitis associated with right-side perinephritis]. 61
2079804 1990
28
Noradrenaline sensitivity and calcium fluxes in arteries from rabbits with perinephritis hypertension. 61
2208798 1990
29
[The sequela of peri-hepatitis due to Chlamydia trachomatis (Fitz-Hugh-Curtis syndrome) seen during an ectopic pregnancy]. 61
2389107 1990
30
Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey): studies of the renin-angiotensin-aldosterone axis and renal hemodynamic function. 61
2677140 1989
31
Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. 61
2524288 1989
32
Skeletal muscle beta 2-adrenoreceptors and the effect of adrenergic drugs on plasma potassium in perinephritis hypertension in rabbits. 61
2541134 1989
33
Platelet cytosolic free calcium before and after antihypertensive treatment in perinephritis hypertension of the rabbit. 61
2571432 1989
34
[Emphysematous pyelonephritis and perinephritis]. 61
2619267 1989
35
[Ultrasound-guided puncture for renal cyst and instillation of povidone iodine]. 61
3245521 1988
36
Desensitization of vascular and platelet alpha 2-adrenoceptors in rabbits with perinephritis hypertension. 61
2897989 1988
37
Electrophysiological properties of the mesenteric artery of the rabbit with perinephritis hypertension. 61
3390614 1988
38
45Ca uptake and the actions of Bay K 8644 on aortic strips from rabbits with perinephritis hypertension. 61
2448370 1987
39
Splenic abscess as complication of perinephric abscess. 61
3629772 1987
40
Myocardial hypertrophy in Macaca fascicularis. Structural remodeling of the collagen matrix. 61
2955170 1987
41
The effects of calcium antagonists on blood pressure and responses to alpha-adrenoceptor agonists in hypertensive rabbits. 61
2886240 1987
42
Perisplenitis and perinephritis in the Curtis-Fitz-Hugh syndrome. 61
3815024 1987
43
Collagen in the hypertrophied, pressure-overloaded myocardium. 61
2947751 1987
44
Effects of long-term administration of propyldazine on blood pressure and counter-regulatory systems in conscious hypertensive dogs. 61
3827411 1986
45
Effects of drugs that activate or inhibit calcium channels on contraction of the aorta from hypertensive rabbits. 61
2434744 1986
46
Cardiac and lymphocyte beta-adrenoceptors in perinephritis hypertension in the rabbit. 61
2425174 1986
47
Effects of hypertension and hypercholesterolemia on vasodilatation in the rabbit. 61
3699879 1986
48
Studies on alpha 2-adrenoceptors in rabbits with perinephritis hypertension. 61
2870119 1986
49
Alterations of the glomerular beta-adrenoceptor-linked adenylate cyclase system in perinephritis hypertension. 61
2419695 1986
50
[An experience in the treatment of severe surgical infectious diseases with combination of antibiotics and human gammaglobulin (SM-4300)]. 61
4079026 1985

Variations for Perinephritis

Expression for Perinephritis

Search GEO for disease gene expression data for Perinephritis.

Pathways for Perinephritis

Pathways related to Perinephritis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 ROS1 PRKCA MST1R GH1 EDNRB EDNRA
2
Show member pathways
12.78 REN PRKCA GH1 ALK ACE
3 12.56 PRKCA EDNRB EDNRA EDN1 ALK
4
Show member pathways
12.41 PRKCA GH1 EDNRB EDN1
5
Show member pathways
12.28 PRKCA EDNRB EDNRA ADRB2
6 12.03 PRKCA MST1R EDNRB EDNRA ADRB2
7 11.87 ROS1 MST1R ALK
8 11.18 PRKCA EDNRB EDNRA EDN1
9 11.16 ROS1 PIK3C2A ALK
10 11.02 EDNRB EDNRA EDN1
11
Show member pathways
10.91 PRKCA EDNRA EDN1
12 10.86 REN EDNRA EDN1 ADRB2 ACE
13 10.79 PRKCA EDNRB EDNRA EDN1

GO Terms for Perinephritis

Cellular components related to Perinephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 TTN ROS1 REN PRKCA PIK3C2A MST1R
2 integral component of plasma membrane GO:0005887 9.63 ROS1 MST1R EDNRB EDNRA ALK ADRB2
3 receptor complex GO:0043235 8.92 ROS1 MST1R ALK ADRB2

Biological processes related to Perinephritis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.14 ROS1 MST1R GH1 EDNRB EDNRA ALK
2 protein phosphorylation GO:0006468 9.91 TTN ROS1 PRKCA MST1R ALK
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 EDNRB EDNRA EDN1
4 phosphorylation GO:0016310 9.8 TTN ROS1 PRKCA PIK3C2A MST1R ALK
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.76 ROS1 MST1R ALK
6 positive regulation of kinase activity GO:0033674 9.67 ROS1 MST1R ALK
7 neural crest cell development GO:0014032 9.62 EDNRA EDN1
8 regulation of blood vessel diameter GO:0097746 9.62 ADRB2 ACE
9 positive regulation of cardiac muscle hypertrophy GO:0010613 9.61 PRKCA EDN1
10 regulation of vasoconstriction GO:0019229 9.61 EDN1 ACE
11 positive regulation of MAP kinase activity GO:0043406 9.61 MST1R GH1 EDN1
12 regulation of pH GO:0006885 9.59 EDNRB EDN1
13 enteric nervous system development GO:0048484 9.58 EDNRB EDNRA
14 amyloid-beta metabolic process GO:0050435 9.57 REN ACE
15 positive regulation of renal sodium excretion GO:0035815 9.56 EDNRB EDN1
16 peptidyl-tyrosine phosphorylation GO:0018108 9.56 TTN ROS1 MST1R ALK
17 positive regulation of urine volume GO:0035810 9.55 EDNRB EDN1
18 angiotensin maturation GO:0002003 9.54 REN ACE
19 artery smooth muscle contraction GO:0014824 9.52 EDNRA EDN1
20 regulation of glucose transmembrane transport GO:0010827 9.48 EDNRA EDN1
21 epithelial fluid transport GO:0042045 9.46 EDNRB EDN1
22 negative regulation of cellular protein metabolic process GO:0032269 9.4 EDNRB EDN1
23 vein smooth muscle contraction GO:0014826 9.37 EDNRB EDN1
24 vasoconstriction GO:0042310 9.33 EDNRB EDNRA EDN1
25 endothelin receptor signaling pathway GO:0086100 9.13 EDNRB EDNRA EDN1
26 regulation of blood pressure GO:0008217 9.02 REN EDNRB EDNRA EDN1 ACE

Molecular functions related to Perinephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.72 TTN ROS1 PRKCA MST1R ALK
2 enzyme binding GO:0019899 9.67 TTN PRKCA MST1R ADRB2
3 kinase activity GO:0016301 9.63 TTN ROS1 PRKCA PIK3C2A MST1R ALK
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 ROS1 MST1R ALK
5 protein tyrosine kinase activity GO:0004713 9.26 TTN ROS1 MST1R ALK
6 endothelin receptor activity GO:0004962 8.62 EDNRB EDNRA

Sources for Perinephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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