MCID: PRN007
MIFTS: 33

Perinephritis

Categories: Nephrological diseases

Aliases & Classifications for Perinephritis

MalaCards integrated aliases for Perinephritis:

Name: Perinephritis 12 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2982
MeSH 43 D010501
UMLS 71 C0031065

Summaries for Perinephritis

MalaCards based summary : Perinephritis is related to hypertension, essential and tempi syndrome. An important gene associated with Perinephritis is REN (Renin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Activation of cAMP-Dependent PKA. Affiliated tissues include kidney, colon and heart, and related phenotypes are Decreased substrate adherent cell growth and behavior/neurological

Wikipedia : 74 Perinephritis is an infection of the surroundings of the kidney either right or left. It can be the... more...

Related Diseases for Perinephritis

Diseases related to Perinephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 hypertension, essential 27.5 REN ADRA2C ADRA2B ADRA1B ADRA1A
2 tempi syndrome 12.1
3 renal cell carcinoma, nonpapillary 10.6
4 pyelonephritis 10.5
5 angiomyolipoma 10.4
6 acute cystitis 10.4
7 hydronephrosis 10.3
8 nephrolithiasis, calcium oxalate 10.3
9 liposarcoma 10.3
10 kidney disease 10.3
11 cystic kidney disease 10.2
12 polyarteritis nodosa 10.2
13 xanthogranulomatous pyelonephritis 10.2
14 acute kidney failure 10.2
15 ureteral obstruction 10.2
16 urinary tract obstruction 10.2
17 acute pyelonephritis 10.2
18 peritonitis 10.2
19 appendicitis 10.1
20 hydrops, lactic acidosis, and sideroblastic anemia 10.1
21 chronic pyelonephritis 10.1
22 toxic shock syndrome 10.1
23 pyuria 10.1
24 erdheim-chester disease 10.1
25 clear cell renal cell carcinoma 10.1
26 well-differentiated liposarcoma 10.1
27 end stage renal failure 10.1
28 vasculitis 10.1
29 oncocytoma 10.0
30 polycystic kidney disease 10.0
31 neurogenic bladder 10.0
32 candidiasis 10.0
33 pleural empyema 10.0
34 renal oncocytoma 10.0
35 adenoma 10.0
36 kidney angiomyolipoma 10.0
37 47,xyy 10.0
38 lymphangiomatosis 10.0
39 retroperitoneal fibrosis 10.0
40 aneurysm 10.0
41 back pain 10.0
42 uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis 9.9
43 varicose veins 9.9
44 vesicoureteral reflux 1 9.9
45 body mass index quantitative trait locus 1 9.9
46 microvascular complications of diabetes 3 9.9
47 microvascular complications of diabetes 4 9.9
48 microvascular complications of diabetes 6 9.9
49 microvascular complications of diabetes 7 9.9
50 aspergillosis 9.9

Graphical network of the top 20 diseases related to Perinephritis:



Diseases related to Perinephritis

Symptoms & Phenotypes for Perinephritis

GenomeRNAi Phenotypes related to Perinephritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.8 ADRA1A ADRA1B ADRA2B

MGI Mouse Phenotypes related to Perinephritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.72 ADRA1A ADRA1B ADRA2B ADRA2C REN
2 cardiovascular system MP:0005385 9.65 ADRA1A ADRA1B ADRA2B ADRA2C REN
3 homeostasis/metabolism MP:0005376 9.55 ADRA1A ADRA1B ADRA2B ADRA2C REN
4 muscle MP:0005369 9.26 ADRA1A ADRA1B ADRA2B REN
5 renal/urinary system MP:0005367 8.92 ADRA1A ADRA1B ADRA2B REN

Drugs & Therapeutics for Perinephritis

Search Clinical Trials , NIH Clinical Center for Perinephritis

Cochrane evidence based reviews: perinephritis

Genetic Tests for Perinephritis

Anatomical Context for Perinephritis

MalaCards organs/tissues related to Perinephritis:

40
Kidney, Colon, Heart, Liver, Uterus, B Cells, Smooth Muscle

Publications for Perinephritis

Articles related to Perinephritis:

(show top 50) (show all 116)
# Title Authors PMID Year
1
Post-Renal Biopsy Acute Kidney Injury and Page Kidney from Intra-Renal Hematoma Aggravated by Reversible Contrast-Induced Nephropathy Following Renal Arterial Embolization. 61
31964858 2020
2
Perinephric stranding and bulky psoas mimicking pyelonephritis in a case of non-Hodgkin lymphoma of kidney. 61
25813655 2015
3
The production process of "Étude sur le Rein des Urinaires", doctoral thesis of Joaquin María Albarrán at the Faculty of Medicine in Paris. 61
24210656 2014
4
[A case of renal arteriovenous fistula complicated with pyelonephritis]. 61
21832877 2011
5
Retroperitoneal perirenal pseudocyst in a Massese breed ram. 61
15945391 2005
6
[Xanthrogranulomatous pyelonephritis with nephrocutaneous fistula]. 61
12765065 2003
7
Apex-to-base dispersion of refractoriness underlies the proarrhythmic effect of hypokalaemia/hypomagnesaemia in the rabbit heart. 61
12122615 2002
8
Regional electrophysiological effects of left ventricular hypertrophy in isolated rabbit hearts under normal and ischaemic conditions. 61
11033114 2000
9
[Imaging of acute urinary infections in adults. Radiologic findings and strategy for imaging procedures]. 61
10995488 2000
10
Bilateral xanthogranulomatous perinephritis without renal parenchymal involvement. 61
10879698 2000
11
Hyperreninemic hypertension secondary to a subcapsular perinephric hematoma in a patient with polyarteritis nodosa. 61
9740170 1998
12
Laparoscopic nephrectomy: the experience of the laparoscopy working group of the German Urologic Association. 61
9628596 1998
13
Action potential prolongation and potassium currents in left-ventricular myocytes isolated from hypertrophied rabbit hearts. 61
9500863 1998
14
Development of severe secondary hypertension in a patient with systemic entomophthoromycosis. 61
9100054 1997
15
[Perinephritis--perinephric abscess, perirenal abscess]. 61
9278014 1997
16
Role of endogenous endothelin-1 in experimental renal hypertension in dogs. 61
7788903 1995
17
[Useful abdominal ultrasonography for diagnosis of Fitz-Hugh-Curtis syndrome: two case reports]. 61
7745311 1995
18
[Lumbar endoscopy: analysis and evaluation of 10 primary operations]. 61
7719361 1995
19
Effects of contraction-excitation feedback on electrophysiology and arrhythmogenesis in rabbits with experimental left ventricular hypertrophy. 61
7954651 1994
20
A characterized model of left ventricular hypertrophy in the rabbit. 61
7919055 1994
21
[Abscess of single kidney complicated by acute perinephritis and diffuse peritonitis]. 61
7823515 1994
22
Page kidney with constrictive perinephritis. 61
8341012 1993
23
Effects of endothelin upon blood pressure in normotensive rabbits and in perinephritis hypertension. 61
1325511 1992
24
Noradrenaline and endothelin-stimulated inositol phosphate formation in arterial smooth muscle from rabbits with perinephritis hypertension. 61
1794209 1991
25
Inositol phosphate formation in arterial smooth muscle from rabbits with perinephritis hypertension. 61
1962806 1990
26
[Chylous peritonitis associated with right-side perinephritis]. 61
2079804 1990
27
Noradrenaline sensitivity and calcium fluxes in arteries from rabbits with perinephritis hypertension. 61
2208798 1990
28
[The sequela of peri-hepatitis due to Chlamydia trachomatis (Fitz-Hugh-Curtis syndrome) seen during an ectopic pregnancy]. 61
2389107 1990
29
Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey): studies of the renin-angiotensin-aldosterone axis and renal hemodynamic function. 61
2677140 1989
30
Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. 61
2524288 1989
31
Skeletal muscle beta 2-adrenoreceptors and the effect of adrenergic drugs on plasma potassium in perinephritis hypertension in rabbits. 61
2541134 1989
32
Platelet cytosolic free calcium before and after antihypertensive treatment in perinephritis hypertension of the rabbit. 61
2571432 1989
33
[Emphysematous pyelonephritis and perinephritis]. 61
2619267 1989
34
[Ultrasound-guided puncture for renal cyst and instillation of povidone iodine]. 61
3245521 1988
35
Desensitization of vascular and platelet alpha 2-adrenoceptors in rabbits with perinephritis hypertension. 61
2897989 1988
36
Electrophysiological properties of the mesenteric artery of the rabbit with perinephritis hypertension. 61
3390614 1988
37
45Ca uptake and the actions of Bay K 8644 on aortic strips from rabbits with perinephritis hypertension. 61
2448370 1987
38
Splenic abscess as complication of perinephric abscess. 61
3629772 1987
39
Myocardial hypertrophy in Macaca fascicularis. Structural remodeling of the collagen matrix. 61
2955170 1987
40
The effects of calcium antagonists on blood pressure and responses to alpha-adrenoceptor agonists in hypertensive rabbits. 61
2886240 1987
41
Perisplenitis and perinephritis in the Curtis-Fitz-Hugh syndrome. 61
3815024 1987
42
Collagen in the hypertrophied, pressure-overloaded myocardium. 61
2947751 1987
43
Effects of long-term administration of propyldazine on blood pressure and counter-regulatory systems in conscious hypertensive dogs. 61
3827411 1986
44
Effects of drugs that activate or inhibit calcium channels on contraction of the aorta from hypertensive rabbits. 61
2434744 1986
45
Cardiac and lymphocyte beta-adrenoceptors in perinephritis hypertension in the rabbit. 61
2425174 1986
46
Effects of hypertension and hypercholesterolemia on vasodilatation in the rabbit. 61
3699879 1986
47
Studies on alpha 2-adrenoceptors in rabbits with perinephritis hypertension. 61
2870119 1986
48
Alterations of the glomerular beta-adrenoceptor-linked adenylate cyclase system in perinephritis hypertension. 61
2419695 1986
49
[An experience in the treatment of severe surgical infectious diseases with combination of antibiotics and human gammaglobulin (SM-4300)]. 61
4079026 1985
50
Effects of two forms of hypertension on atherosclerosis in the hyperlipidemic baboon. 61
3899070 1985

Variations for Perinephritis

Expression for Perinephritis

Search GEO for disease gene expression data for Perinephritis.

Pathways for Perinephritis

Pathways related to Perinephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 ADRA2C ADRA2B ADRA1B ADRA1A
2
Show member pathways
12.92 ADRA2C ADRA2B ADRA1B ADRA1A
3
Show member pathways
12.24 ADRA2B ADRA1B ADRA1A
4
Show member pathways
12.06 ADRA2C ADRA2B ADRA1B ADRA1A
5
Show member pathways
11.69 ADRA1B ADRA1A
6
Show member pathways
11.69 ADRA2C ADRA2B ADRA1B ADRA1A
7
Show member pathways
11.54 ADRA1B ADRA1A
8
Show member pathways
11.4 ADRA2C ADRA2B
9
Show member pathways
11.3 ADRA2C ADRA2B ADRA1B ADRA1A
10 10.29 ADRA2C ADRA2B ADRA1B ADRA1A

GO Terms for Perinephritis

Cellular components related to Perinephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.65 REN ADRA2C ADRA2B ADRA1B ADRA1A
2 integral component of plasma membrane GO:0005887 9.26 ADRA2C ADRA2B ADRA1B ADRA1A
3 caveola GO:0005901 9.16 ADRA1B ADRA1A
4 integral component of postsynaptic membrane GO:0099055 8.62 ADRA2C ADRA1A

Biological processes related to Perinephritis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.91 ADRA2C ADRA2B ADRA1B ADRA1A
2 G protein-coupled receptor signaling pathway GO:0007186 9.87 ADRA2C ADRA2B ADRA1B ADRA1A
3 cell-cell signaling GO:0007267 9.71 ADRA2C ADRA2B ADRA1B ADRA1A
4 positive regulation of MAPK cascade GO:0043410 9.62 ADRA2C ADRA2B ADRA1B ADRA1A
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.61 ADRA1B ADRA1A
6 platelet activation GO:0030168 9.6 ADRA2C ADRA2B
7 positive regulation of neuron differentiation GO:0045666 9.59 ADRA2C ADRA2B
8 female pregnancy GO:0007565 9.58 ADRA2C ADRA2B
9 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.58 ADRA1B ADRA1A
10 activation of protein kinase B activity GO:0032148 9.56 ADRA2C ADRA2B
11 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.56 ADRA2C ADRA2B ADRA1B ADRA1A
12 regulation of cardiac muscle contraction GO:0055117 9.55 ADRA1B ADRA1A
13 positive regulation of smooth muscle contraction GO:0045987 9.54 ADRA1B ADRA1A
14 positive regulation of vasoconstriction GO:0045907 9.54 ADRA2C ADRA1B ADRA1A
15 regulation of smooth muscle contraction GO:0006940 9.52 ADRA2C ADRA2B
16 regulation of muscle contraction GO:0006937 9.51 ADRA1B ADRA1A
17 negative regulation of norepinephrine secretion GO:0010700 9.49 ADRA2C ADRA2B
18 receptor transactivation GO:0035624 9.48 ADRA2C ADRA2B
19 negative regulation of epinephrine secretion GO:0032811 9.46 ADRA2C ADRA2B
20 regulation of vasoconstriction GO:0019229 9.46 ADRA2C ADRA2B ADRA1B ADRA1A
21 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 9.43 ADRA1B ADRA1A
22 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.26 ADRA2C ADRA2B ADRA1B ADRA1A
23 adrenergic receptor signaling pathway GO:0071875 8.92 ADRA2C ADRA2B ADRA1B ADRA1A

Molecular functions related to Perinephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.54 ADRA2B ADRA1B ADRA1A
2 protein heterodimerization activity GO:0046982 9.5 ADRA2C ADRA1B ADRA1A
3 epinephrine binding GO:0051379 9.26 ADRA2C ADRA2B
4 alpha2-adrenergic receptor activity GO:0004938 9.16 ADRA2C ADRA2B
5 alpha1-adrenergic receptor activity GO:0004937 8.96 ADRA1B ADRA1A
6 adrenergic receptor activity GO:0004935 8.92 ADRA2C ADRA2B ADRA1B ADRA1A

Sources for Perinephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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