MCID: PRN007
MIFTS: 36

Perinephritis

Categories: Nephrological diseases

Aliases & Classifications for Perinephritis

MalaCards integrated aliases for Perinephritis:

Name: Perinephritis 12 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:2982
MeSH 44 D010501
UMLS 72 C0031065

Summaries for Perinephritis

MalaCards based summary : Perinephritis is related to renovascular hypertension and malignant hypertension. An important gene associated with Perinephritis is ADRA2C (Adrenoceptor Alpha 2C), and among its related pathways/superpathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Affiliated tissues include kidney, colon and heart, and related phenotypes are Decreased substrate adherent cell growth and cardiovascular system

Related Diseases for Perinephritis

Diseases related to Perinephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 renovascular hypertension 30.0 REN EDN1
2 malignant hypertension 29.8 REN EDN1
3 renal tuberculosis 29.8 REN EDN1
4 autosomal dominant polycystic kidney disease 28.4 REN EDNRB EDNRA EDN1
5 pulmonary hypertension 28.1 REN EDNRB EDNRA EDN1
6 hypertension, essential 25.8 REN EDNRB EDNRA EDN1 ADRB3 ADRB2
7 tempi syndrome 12.2
8 renal cell carcinoma, nonpapillary 10.6
9 pyelonephritis 10.5
10 horner's syndrome 10.5 ADRA2A ADRA1A
11 ocular hypotension 10.5 ADRB2 ADRB1
12 meningococcal infection 10.4 ADRB2 ADRB1
13 angiomyolipoma 10.4
14 acute cystitis 10.4
15 hydronephrosis 10.3
16 nephrolithiasis, calcium oxalate 10.3
17 liposarcoma 10.3
18 kidney disease 10.3
19 resting heart rate, variation in 10.2 ADRB2 ADRB1 ADRA2B
20 cystic kidney disease 10.2
21 polyarteritis nodosa 10.2
22 malignant renovascular hypertension 10.2 REN EDN1
23 malignant hypertensive renal disease 10.2 REN EDN1
24 xanthogranulomatous pyelonephritis 10.2
25 acute kidney failure 10.2
26 ureteral obstruction 10.2
27 urinary tract obstruction 10.2
28 acute pyelonephritis 10.2
29 peritonitis 10.2
30 malignant secondary hypertension 10.2 REN EDN1
31 raynaud phenomenon 10.2 EDN1 ADRA2C
32 appendicitis 10.1
33 hydrops, lactic acidosis, and sideroblastic anemia 10.1
34 chronic pyelonephritis 10.1
35 toxic shock syndrome 10.1
36 pyuria 10.1
37 erdheim-chester disease 10.1
38 clear cell renal cell carcinoma 10.1
39 well-differentiated liposarcoma 10.1
40 end stage renal failure 10.1
41 vasculitis 10.1
42 hepatorenal syndrome 10.1 REN EDN1
43 polycystic kidney disease 10.0
44 neurogenic bladder 10.0
45 candidiasis 10.0
46 pleural empyema 10.0
47 adenoma 10.0
48 kidney angiomyolipoma 10.0
49 47,xyy 10.0
50 lymphangiomatosis 10.0

Graphical network of the top 20 diseases related to Perinephritis:



Diseases related to Perinephritis

Symptoms & Phenotypes for Perinephritis

GenomeRNAi Phenotypes related to Perinephritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.92 ADRA1A ADRA1B ADRA1D ADRA2B

MGI Mouse Phenotypes related to Perinephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
2 behavior/neurological MP:0005386 10.22 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
3 homeostasis/metabolism MP:0005376 10.1 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB1
4 growth/size/body region MP:0005378 10.02 ADRA1B ADRA2B ADRB1 ADRB2 ADRB3 EDN1
5 mortality/aging MP:0010768 9.96 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB1
6 endocrine/exocrine gland MP:0005379 9.95 ADRA1B ADRB1 ADRB2 ADRB3 EDN1 EDNRA
7 embryo MP:0005380 9.91 ADRA2A ADRA2B ADRA2C EDN1 EDNRA EDNRB
8 muscle MP:0005369 9.85 ADRA1A ADRA1B ADRA1D ADRA2B ADRB1 ADRB2
9 nervous system MP:0003631 9.61 ADRA1B ADRA1D ADRA2A ADRA2C ADRB2 EDN1
10 renal/urinary system MP:0005367 9.17 ADRA1A ADRA1B ADRA2B EDN1 EDNRA EDNRB

Drugs & Therapeutics for Perinephritis

Search Clinical Trials , NIH Clinical Center for Perinephritis

Cochrane evidence based reviews: perinephritis

Genetic Tests for Perinephritis

Anatomical Context for Perinephritis

MalaCards organs/tissues related to Perinephritis:

41
Kidney, Colon, Heart, Smooth Muscle, Skeletal Muscle

Publications for Perinephritis

Articles related to Perinephritis:

(show top 50) (show all 115)
# Title Authors PMID Year
1
Perinephric stranding and bulky psoas mimicking pyelonephritis in a case of non-Hodgkin lymphoma of kidney. 38
25813655 2015
2
The production process of "Étude sur le Rein des Urinaires", doctoral thesis of Joaquin María Albarrán at the Faculty of Medicine in Paris. 38
24210656 2014
3
[A case of renal arteriovenous fistula complicated with pyelonephritis]. 38
21832877 2011
4
Retroperitoneal perirenal pseudocyst in a Massese breed ram. 38
15945391 2005
5
[Xanthrogranulomatous pyelonephritis with nephrocutaneous fistula]. 38
12765065 2003
6
Apex-to-base dispersion of refractoriness underlies the proarrhythmic effect of hypokalaemia/hypomagnesaemia in the rabbit heart. 38
12122615 2002
7
Regional electrophysiological effects of left ventricular hypertrophy in isolated rabbit hearts under normal and ischaemic conditions. 38
11033114 2000
8
[Imaging of acute urinary infections in adults. Radiologic findings and strategy for imaging procedures]. 38
10995488 2000
9
Bilateral xanthogranulomatous perinephritis without renal parenchymal involvement. 38
10879698 2000
10
Hyperreninemic hypertension secondary to a subcapsular perinephric hematoma in a patient with polyarteritis nodosa. 38
9740170 1998
11
Laparoscopic nephrectomy: the experience of the laparoscopy working group of the German Urologic Association. 38
9628596 1998
12
Action potential prolongation and potassium currents in left-ventricular myocytes isolated from hypertrophied rabbit hearts. 38
9500863 1998
13
Development of severe secondary hypertension in a patient with systemic entomophthoromycosis. 38
9100054 1997
14
[Perinephritis--perinephric abscess, perirenal abscess]. 38
9278014 1997
15
Role of endogenous endothelin-1 in experimental renal hypertension in dogs. 38
7788903 1995
16
[Useful abdominal ultrasonography for diagnosis of Fitz-Hugh-Curtis syndrome: two case reports]. 38
7745311 1995
17
[Lumbar endoscopy: analysis and evaluation of 10 primary operations]. 38
7719361 1995
18
Effects of contraction-excitation feedback on electrophysiology and arrhythmogenesis in rabbits with experimental left ventricular hypertrophy. 38
7954651 1994
19
A characterized model of left ventricular hypertrophy in the rabbit. 38
7919055 1994
20
[Abscess of single kidney complicated by acute perinephritis and diffuse peritonitis]. 38
7823515 1994
21
Page kidney with constrictive perinephritis. 38
8341012 1993
22
Effects of endothelin upon blood pressure in normotensive rabbits and in perinephritis hypertension. 38
1325511 1992
23
Noradrenaline and endothelin-stimulated inositol phosphate formation in arterial smooth muscle from rabbits with perinephritis hypertension. 38
1794209 1991
24
[Chylous peritonitis associated with right-side perinephritis]. 38
2079804 1990
25
Inositol phosphate formation in arterial smooth muscle from rabbits with perinephritis hypertension. 38
1962806 1990
26
Noradrenaline sensitivity and calcium fluxes in arteries from rabbits with perinephritis hypertension. 38
2208798 1990
27
[The sequela of peri-hepatitis due to Chlamydia trachomatis (Fitz-Hugh-Curtis syndrome) seen during an ectopic pregnancy]. 38
2389107 1990
28
Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey): studies of the renin-angiotensin-aldosterone axis and renal hemodynamic function. 38
2677140 1989
29
Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. 38
2524288 1989
30
Skeletal muscle beta 2-adrenoreceptors and the effect of adrenergic drugs on plasma potassium in perinephritis hypertension in rabbits. 38
2541134 1989
31
Platelet cytosolic free calcium before and after antihypertensive treatment in perinephritis hypertension of the rabbit. 38
2571432 1989
32
[Emphysematous pyelonephritis and perinephritis]. 38
2619267 1989
33
[Ultrasound-guided puncture for renal cyst and instillation of povidone iodine]. 38
3245521 1988
34
Desensitization of vascular and platelet alpha 2-adrenoceptors in rabbits with perinephritis hypertension. 38
2897989 1988
35
Electrophysiological properties of the mesenteric artery of the rabbit with perinephritis hypertension. 38
3390614 1988
36
45Ca uptake and the actions of Bay K 8644 on aortic strips from rabbits with perinephritis hypertension. 38
2448370 1987
37
Splenic abscess as complication of perinephric abscess. 38
3629772 1987
38
Myocardial hypertrophy in Macaca fascicularis. Structural remodeling of the collagen matrix. 38
2955170 1987
39
The effects of calcium antagonists on blood pressure and responses to alpha-adrenoceptor agonists in hypertensive rabbits. 38
2886240 1987
40
Perisplenitis and perinephritis in the Curtis-Fitz-Hugh syndrome. 38
3815024 1987
41
Collagen in the hypertrophied, pressure-overloaded myocardium. 38
2947751 1987
42
Effects of long-term administration of propyldazine on blood pressure and counter-regulatory systems in conscious hypertensive dogs. 38
3827411 1986
43
Effects of drugs that activate or inhibit calcium channels on contraction of the aorta from hypertensive rabbits. 38
2434744 1986
44
Cardiac and lymphocyte beta-adrenoceptors in perinephritis hypertension in the rabbit. 38
2425174 1986
45
Effects of hypertension and hypercholesterolemia on vasodilatation in the rabbit. 38
3699879 1986
46
Studies on alpha 2-adrenoceptors in rabbits with perinephritis hypertension. 38
2870119 1986
47
Alterations of the glomerular beta-adrenoceptor-linked adenylate cyclase system in perinephritis hypertension. 38
2419695 1986
48
Effects of two forms of hypertension on atherosclerosis in the hyperlipidemic baboon. 38
3899070 1985
49
[An experience in the treatment of severe surgical infectious diseases with combination of antibiotics and human gammaglobulin (SM-4300)]. 38
4079026 1985
50
Systemic and regional haemodynamic profile of captopril in conscious rabbits with bilateral cellophane perinephritis hypertension. 38
3912085 1985

Variations for Perinephritis

Expression for Perinephritis

Search GEO for disease gene expression data for Perinephritis.

Pathways for Perinephritis

Pathways related to Perinephritis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 EDNRB EDNRA EDN1 ADRB3 ADRB2 ADRB1
2
Show member pathways
13.43 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3
Show member pathways
13.32 EDNRB EDNRA EDN1 ADRB3 ADRB2 ADRB1
4
Show member pathways
12.74 EDNRA EDN1 ADRB2 ADRB1 ADRA2B ADRA2A
5
Show member pathways
12.73 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
6
Show member pathways
12.46 ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
7
Show member pathways
12.38 ADRB2 ADRA2C ADRA2B ADRA2A
8
Show member pathways
12.19 ADRA2C ADRA2B ADRA2A ADRA1D ADRA1B ADRA1A
9
Show member pathways
12.13 ADRB3 ADRB2 ADRB1
10 12.13 EDNRA ADRB2 ADRB1
11
Show member pathways
12.13 ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
12
Show member pathways
12.05 EDNRB EDNRA ADRB3 ADRB2 ADRB1 ADRA1D
13 11.95 ADRB3 ADRB2 ADRB1
14
Show member pathways
11.86 ADRA1D ADRA1B ADRA1A
15 11.78 EDNRA ADRB2 ADRA1D
16
Show member pathways
11.76 ADRA2C ADRA2B ADRA2A
17 11.69 REN EDNRA ADRB3 ADRB2 ADRB1
18 11.56 ADRB2 ADRB1 ADRA2A ADRA1D
19 11.49 ADRB3 ADRB2 ADRB1
20 11.47 EDNRB EDNRA EDN1
21
Show member pathways
11.32 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
22 11.29 EDNRA ADRB2 ADRB1 ADRA2B ADRA2A ADRA1B
23 11.25 EDNRB EDNRA EDN1 ADRB1 ADRA1A
24 11.2 EDN1 ADRB1
25 11.2 EDNRB EDNRA EDN1
26
Show member pathways
11.03 EDNRA EDN1
27 10.92 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1D

GO Terms for Perinephritis

Cellular components related to Perinephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.9 EDNRB EDNRA ADRB3 ADRB2 ADRB1 ADRA2C
2 plasma membrane GO:0005886 9.73 REN EDNRB EDNRA ADRB3 ADRB2 ADRB1
3 receptor complex GO:0043235 9.5 ADRB3 ADRB2 ADRA2A
4 integral component of plasma membrane GO:0005887 9.36 EDNRB EDNRA ADRB3 ADRB2 ADRB1 ADRA2C
5 membrane GO:0016020 10.03 REN EDNRB EDNRA ADRB3 ADRB2 ADRB1

Biological processes related to Perinephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.95 EDNRB EDNRA EDN1 ADRA1B ADRA1A
2 cell-cell signaling GO:0007267 9.95 EDN1 ADRA2C ADRA2B ADRA1D ADRA1B ADRA1A
3 positive regulation of MAPK cascade GO:0043410 9.91 ADRB3 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1B
4 response to lipopolysaccharide GO:0032496 9.88 REN EDNRB EDN1
5 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.88 ADRB3 ADRB2 ADRB1 ADRA2A
6 platelet activation GO:0030168 9.86 ADRA2C ADRA2B ADRA2A
7 regulation of blood pressure GO:0008217 9.86 REN EDNRB EDNRA EDN1
8 positive regulation of cold-induced thermogenesis GO:0120162 9.85 ADRB3 ADRB2 ADRB1
9 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.83 EDNRA EDN1 ADRA2A
10 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.82 EDNRB ADRA1B ADRA1A
11 activation of protein kinase B activity GO:0032148 9.8 ADRA2C ADRA2B ADRA2A
12 regulation of sensory perception of pain GO:0051930 9.8 EDNRB EDN1 ADRA2C
13 activation of adenylate cyclase activity GO:0007190 9.8 EDNRA ADRB3 ADRB2 ADRB1
14 positive regulation of vasoconstriction GO:0045907 9.79 ADRA2C ADRA1B ADRA1A
15 positive regulation of smooth muscle contraction GO:0045987 9.75 EDN1 ADRA1B ADRA1A
16 vasoconstriction GO:0042310 9.74 EDNRB EDNRA EDN1
17 regulation of smooth muscle contraction GO:0006940 9.73 ADRB2 ADRA2C ADRA2B ADRA2A
18 regulation of vasoconstriction GO:0019229 9.73 EDN1 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
19 response to cold GO:0009409 9.72 ADRB2 ADRB1
20 respiratory gaseous exchange GO:0007585 9.72 EDNRA EDN1
21 activation of phospholipase C activity GO:0007202 9.71 EDNRA ADRA1A
22 brown fat cell differentiation GO:0050873 9.71 ADRB2 ADRB1
23 branching involved in blood vessel morphogenesis GO:0001569 9.71 EDNRA EDN1
24 positive regulation of cardiac muscle hypertrophy GO:0010613 9.71 EDN1 ADRA1A
25 negative regulation of norepinephrine secretion GO:0010700 9.71 ADRA2C ADRA2B ADRA2A
26 neural crest cell development GO:0014032 9.7 EDNRA EDN1
27 positive regulation of heart rate GO:0010460 9.7 EDN1 ADRA1A
28 regulation of cardiac muscle contraction GO:0055117 9.7 ADRA1B ADRA1A
29 regulation of pH GO:0006885 9.7 EDNRB EDN1
30 receptor transactivation GO:0035624 9.7 ADRA2C ADRA2B ADRA2A
31 adrenergic receptor signaling pathway GO:0071875 9.7 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1D ADRA1B
32 regulation of muscle contraction GO:0006937 9.69 ADRA1B ADRA1A
33 smooth muscle contraction GO:0006939 9.69 EDNRA ADRA1A
34 positive regulation of urine volume GO:0035810 9.69 EDNRB EDN1
35 negative regulation of epinephrine secretion GO:0032811 9.69 ADRA2C ADRA2B ADRA2A
36 positive regulation of renal sodium excretion GO:0035815 9.68 EDNRB EDN1
37 negative regulation of multicellular organism growth GO:0040015 9.68 ADRB2 ADRB1
38 enteric nervous system development GO:0048484 9.68 EDNRB EDNRA
39 artery smooth muscle contraction GO:0014824 9.67 EDNRA EDN1
40 diet induced thermogenesis GO:0002024 9.67 ADRB2 ADRB1
41 regulation of glucose transmembrane transport GO:0010827 9.66 EDNRA EDN1
42 negative regulation of cellular protein metabolic process GO:0032269 9.66 EDNRB EDN1
43 epithelial fluid transport GO:0042045 9.65 EDNRB EDN1
44 vein smooth muscle contraction GO:0014826 9.64 EDNRB EDN1
45 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 9.64 ADRA1B ADRA1A
46 desensitization of G protein-coupled receptor signaling pathway by arrestin GO:0002032 9.63 ADRB3 ADRB2
47 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.63 ADRB3 ADRB2 ADRB1
48 positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997 9.61 ADRB1 ADRA1A
49 positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 9.61 ADRB1 ADRA1A
50 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.61 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A

Molecular functions related to Perinephritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.91 EDNRB EDNRA ADRB3 ADRB2 ADRB1 ADRA2B
2 protein heterodimerization activity GO:0046982 9.89 ADRB1 ADRA2C ADRA2A ADRA1B ADRA1A
3 alpha2-adrenergic receptor activity GO:0004938 9.54 ADRA2C ADRA2B ADRA2A
4 alpha1-adrenergic receptor activity GO:0004937 9.5 ADRA1D ADRA1B ADRA1A
5 alpha-2A adrenergic receptor binding GO:0031694 9.48 ADRB1 ADRA2C
6 norepinephrine binding GO:0051380 9.46 ADRB3 ADRB2 ADRB1 ADRA2A
7 endothelin receptor activity GO:0004962 9.43 EDNRB EDNRA
8 epinephrine binding GO:0051379 9.43 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
9 beta-adrenergic receptor activity GO:0004939 9.4 ADRB3 ADRB1
10 adrenergic receptor activity GO:0004935 9.28 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
11 protein binding GO:0005515 10.27 REN EDNRB EDNRA EDN1 ADRB3 ADRB2

Sources for Perinephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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