MCID: PRD002
MIFTS: 36

Periodic Limb Movement Disorder

Categories: Mental diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Periodic Limb Movement Disorder

MalaCards integrated aliases for Periodic Limb Movement Disorder:

Name: Periodic Limb Movement Disorder 11 75 53 14 16 33
Nocturnal Myoclonus Syndrome 43 71
Nocturnal Myoclonus 11

Classifications:



External Ids:

Disease Ontology 11 DOID:9207
ICD9CM 34 327.51
MeSH 43 D020189
SNOMED-CT 68 418763003
ICD11 33 1846518306
UMLS 71 C0751774

Summaries for Periodic Limb Movement Disorder

Disease Ontology: 11 A sleep disorder that involves involuntary limb movement during sleep.

MalaCards based summary: Periodic Limb Movement Disorder, also known as nocturnal myoclonus syndrome, is related to restless legs syndrome and hypersomnia. An important gene associated with Periodic Limb Movement Disorder is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Melatonin metabolism and effects and Methylphenidate Pathway, Pharmacodynamics. The drugs Iron and Iron Supplement have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, globus pallidus and brain, and related phenotypes are nervous system and muscle

Wikipedia: 75 Periodic limb movement disorder (PLMD) is a sleep disorder where the patient moves limbs involuntarily... more...

Related Diseases for Periodic Limb Movement Disorder

Diseases related to Periodic Limb Movement Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 restless legs syndrome 31.9 SLC6A3 SKOR1 HCRT DRD2 BTBD9
2 hypersomnia 30.9 HLA-DQB1 HCRT
3 idiopathic hypersomnia 30.9 HLA-DQB1 HCRT
4 narcolepsy 1 30.4 HLA-DQB1 HCRT
5 attention deficit-hyperactivity disorder 30.4 SLC6A3 PER2 HCRT DRD2
6 narcolepsy 30.2 SLC6A3 HLA-DQB1 HCRTR2 HCRT DRD2
7 rem sleep behavior disorder 30.1 SLC6A3 PER2 PDSS2 HCRT
8 sleep disorder 29.8 SLC6A3 PER3 PER2 PDSS2 HLA-DQB1 HCRTR2
9 delayed sleep phase disorder 29.8 PER3 PER2 HCRT
10 stiff-person syndrome 29.8 GLRB GLRA1
11 hyperekplexia 29.7 SLC6A5 SLC6A3 GLRB GLRA1
12 movement disease 11.0
13 sleep apnea 10.6
14 apnea, obstructive sleep 10.5
15 restless legs syndrome 6 10.5
16 iron metabolism disease 10.4
17 narcolepsy 2 10.3 HLA-DQB1 HCRT
18 kleine-levin hibernation syndrome 10.3 HLA-DQB1 HCRT
19 osgood-schlatter's disease 10.3 SKOR1 BTBD9
20 chronic tic disorder 10.2 DRD2 BTBD9
21 kleptomania 10.2 SLC6A3 DRD2
22 drug psychosis 10.2 SLC6A3 DRD2
23 drug-induced mental disorder 10.2 SLC6A3 DRD2
24 polyneuropathy 10.2
25 uremia 10.2
26 pathological gambling 10.2 SLC6A3 DRD2
27 lingual-facial-buccal dyskinesia 10.2 SLC6A3 DRD2
28 substance-induced psychosis 10.2 SLC6A3 DRD2
29 delusional disorder 10.2 SLC6A3 DRD2
30 central sleep apnea 10.2 ZNF221 HCRT
31 impulse control disorder 10.2 SLC6A3 DRD2
32 dysthymic disorder 10.1 SLC6A3 HCRT
33 striatonigral degeneration 10.1 SLC6A3 DRD2
34 opiate dependence 10.1 SLC6A3 HCRT DRD2
35 withdrawal disorder 10.1 SLC6A3 HCRT DRD2
36 tic disorder 10.1 SLC6A3 DRD2 BTBD9
37 post-traumatic stress disorder 10.1 SLC6A3 HCRT DRD2
38 substance abuse 10.1 SLC6A3 HCRT DRD2
39 supranuclear palsy, progressive, 1 10.1 SLC6A3 HCRT DRD2
40 eating disorder 10.1 SLC6A3 HCRT DRD2
41 gilles de la tourette syndrome 10.1 SLC6A3 DRD2 BTBD9
42 articulation disorder 10.1 SLC6A3 DRD2
43 specific developmental disorder 10.1 SLC6A3 HCRT DRD2
44 oppositional defiant disorder 10.1 SLC6A3 DRD2
45 phobic disorder 10.1 SLC6A3 GLRB DRD2
46 recurrent hypersomnia 10.1 HLA-DQB1 HCRTR2 HCRT
47 melkersson-rosenthal syndrome 10.1
48 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 10.1
49 anxiety 10.1
50 spinal disease 10.1

Graphical network of the top 20 diseases related to Periodic Limb Movement Disorder:



Diseases related to Periodic Limb Movement Disorder

Symptoms & Phenotypes for Periodic Limb Movement Disorder

MGI Mouse Phenotypes related to Periodic Limb Movement Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.93 BTBD9 DRD2 GLRA1 GLRB HCRT HCRTR2
2 muscle MP:0005369 9.61 DRD2 GLRA1 GLRB HCRT HCRTR2 HLA-DQB1
3 behavior/neurological MP:0005386 9.4 BTBD9 DRD2 GLRA1 GLRB HCRT HCRTR2

Drugs & Therapeutics for Periodic Limb Movement Disorder

Drugs for Periodic Limb Movement Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 29936
2 Iron Supplement Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Frequency and Timing of Oral Iron Administration for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder Enrolling by invitation NCT04610827 Phase 4 Ferrous sulfate
2 Periodic Limb Movement Syndrome in Patients With Cerebral Small Vessel Disease: a Clinical and Neuropsychological Study. Unknown status NCT04569643
3 Consequences of Post Stroke Polysomnographic Abnormalities on Functionnal Recovery and Survival After an Ischemic Stroke Completed NCT04816136
4 Periodic Leg Movement's Diagnosis in Spinal Cord Injury: Actigraphy as an Alternative for Polysomnography? Recruiting NCT04618978
5 Examining the Link Between Clinical and Physiological Sleep Data and Health-related Outcomes Active, not recruiting NCT03383354

Search NIH Clinical Center for Periodic Limb Movement Disorder

Cochrane evidence based reviews: nocturnal myoclonus syndrome

Genetic Tests for Periodic Limb Movement Disorder

Anatomical Context for Periodic Limb Movement Disorder

Organs/tissues related to Periodic Limb Movement Disorder:

MalaCards : Spinal Cord, Globus Pallidus, Brain, Eye, Kidney, Heart, Tongue

Publications for Periodic Limb Movement Disorder

Articles related to Periodic Limb Movement Disorder:

(show top 50) (show all 394)
# Title Authors PMID Year
1
Lamotrigine in the treatment of nocturnal myoclonus syndrome (NMS): two case reports. 53 62
8739847 1996
2
Single photon emission tomography (SPET) imaging of dopamine D2 receptors in the course of dopamine replacement therapy in patients with nocturnal myoclonus syndrome (NMS). 53 62
8579804 1995
3
Nocturnal myoclonus syndrome (periodic movements in sleep) related to central dopamine D2-receptor alteration. 53 62
7786913 1995
4
Sleep disorders and polysomnography findings in patients with autoimmune encephalitis. 62
36454441 2022
5
Trazodone affects periodic leg movements and chin muscle tone during sleep less than selective serotonin reuptake inhibitor antidepressants in children. 62
35975551 2022
6
More than sleepiness: prevalence and relevance of nonclassical symptoms of obstructive sleep apnea. 62
36101923 2022
7
Intravenous iron therapy in the pediatric sleep clinic: a single institution experience. 62
35912699 2022
8
Practice recommendations for the role of physiotherapy in the management of sleep disorders: the 2022 Brazilian Sleep Association Guidelines. 62
36419815 2022
9
Deep Learning for Automatic Detection of Periodic Limb Movement Disorder Based on Electrocardiogram Signals. 62
36140550 2022
10
Restless sleep disorder, restless legs syndrome, and periodic limb movement disorder-Sleep in motion! 62
33527761 2022
11
Large body movements on video polysomnography are associated with daytime dysfunction in children with restless sleep disorder. 62
35022768 2022
12
Interbeat interval-based sleep staging: work in progress toward real-time implementation. 62
35297780 2022
13
Nocturnal Hypoxia and Sleep Fragmentation May Drive Neurodegenerative Processes: The Compared Effects of Obstructive Sleep Apnea Syndrome and Periodic Limb Movement Disorder on Alzheimer's Disease Biomarkers. 62
35570484 2022
14
Periodic limb movements during sleep: a narrative review. 62
34992826 2021
15
Clinical efficacy and safety of intravenous ferric carboxymaltose treatment of pediatric restless legs syndrome and periodic limb movement disorder. 62
34562823 2021
16
Clinical manifestations and polysomnography-based analysis in nine cases of probable sporadic Creutzfeldt-Jakob disease. 62
33559029 2021
17
Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters. 62
35186202 2021
18
Nocturnal eye movements in patients with idiopathic rapid eye movement sleep behaviour disorder and patients with Parkinson's disease. 62
32860309 2021
19
Pediatric Restless Legs Syndrome. 62
33985655 2021
20
Artificial Neural Networks Analysis of polysomnographic and clinical features in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): from sleep alteration to "Brain Fog". 62
34326674 2021
21
Prevalence of sleep disorders among medical students of Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. 62
33575230 2020
22
Prevalence of narcolepsy and other sleep disorders and frequency of diagnostic tests from 2013-2016 in insured patients actively seeking care. 62
32807293 2020
23
Overview of sleep disturbances and their management in Parkinson plus disorders. 62
32446010 2020
24
Sleep-Wake Disorders in Childhood. 62
32756235 2020
25
Not what it seems to be: Depression versus periodic limb movement disorder. 62
33165358 2020
26
Subjective and objective features of sleep disorders in patients with acute ischemic or haemorrhagic stroke: It is not only sleep apnoea which is important. 62
31837521 2020
27
Retrospective Analysis of Risk Factors for Periodic Limb Movements in a Large Cohort of Insomnia and Chronic Fatigue Patients. 62
31454848 2020
28
High prevalence of periodic limb movements of sleep in children with Down syndrome. 62
31992397 2020
29
Utility of the Sleep Disorders Inventory for Students in Clinically Referred Youth With Insomnia: Risk Identification and Relationship With Polysomnographic Measures. 62
30793972 2020
30
Comorbidities in children with elevated periodic limb movement index during sleep. 62
31555831 2020
31
Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review. 62
31678660 2019
32
Clinical presentation, diagnosis and polysomnographic findings in children with migraine referred to sleep clinics. 62
31606650 2019
33
Objective measures of sleep disturbances in children with Potocki-Lupski syndrome. 62
31342617 2019
34
Can body position and sleep stages influence motor patterns in periodic limb movement disorder? 62
31526968 2019
35
How does one choose the correct pharmacotherapy for a pediatric patient with restless legs syndrome and periodic limb movement disorder?: Expert Guidance. 62
31177869 2019
36
Sleep and Limb Movement Characteristics of Children With Atopic Dermatitis Coincidentally Undergoing Clinical Polysomnography. 62
31482832 2019
37
Validation of the REM sleep behavior disorder screening questionnaire in the Czech population. 62
31164104 2019
38
Improvement of Parasomnias After Treatment of Restless Leg Syndrome/ Periodic Limb Movement Disorder in Children. 62
31053208 2019
39
Confirmatory factor analysis of the SLEEP-50 Questionnaire in Trichotillomania (Hair-Pulling Disorder) and Excoriation (Skin-Picking) Disorder. 62
30654305 2019
40
Sleep Disorders. 62
30292731 2019
41
Depression is differently associated with sleep measurement in obstructive sleep apnea, restless leg syndrome and periodic limb movement disorder. 62
30639562 2019
42
Ullanlinna Narcolepsy Scale in diagnosis of narcolepsy. 62
30476331 2019
43
Polysomnography. 62
31277862 2019
44
Validation of a new data-driven automated algorithm for muscular activity detection in REM sleep behavior disorder. 62
30468824 2019
45
Subjective and objective assessments of sleep problems in children with attention deficit/hyperactivity disorder and the effects of methylphenidate treatment. 62
30709577 2018
46
Comparison of computerized methods for rapid eye movement sleep without atonia detection. 62
30011023 2018
47
Probabilistic Data-Driven Method for Limb Movement Detection during Sleep. 62
30440364 2018
48
Sleeping chILD: Neuroendocrine cell hyperplasia of infancy and polysomnography. 62
29766677 2018
49
Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline. 62
29991437 2018
50
Sleep disorders in the elderly: a growing challenge. 62
29878472 2018

Variations for Periodic Limb Movement Disorder

Expression for Periodic Limb Movement Disorder

Search GEO for disease gene expression data for Periodic Limb Movement Disorder.

Pathways for Periodic Limb Movement Disorder

Pathways related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.65 PER3 PER2
2
Show member pathways
10.32 SLC6A3 DRD2
3 9.53 HCRTR2 HCRT

GO Terms for Periodic Limb Movement Disorder

Cellular components related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005887 10.21 DRD2 GLRA1 GLRB HCRTR2 SLC6A3 SLC6A5
2 plasma membrane GO:0005886 10.21 DRD2 GLRA1 GLRB HCRTR2 SLC6A3 SLC6A5
3 presynaptic membrane GO:0042734 9.67 SLC6A5 SLC6A3 DRD2
4 postsynaptic membrane GO:0045211 9.63 SLC6A3 GLRB GLRA1 DRD2
5 dopaminergic synapse GO:0098691 9.62 SLC6A3 DRD2
6 obsolete integral component of presynaptic membrane GO:0099056 9.13 SLC6A5 SLC6A3 DRD2
7 glycinergic synapse GO:0098690 9.1 SLC6A5 GLRB GLRA1

Biological processes related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 10.02 SLC6A5 HCRTR2 HCRT GLRB GLRA1
2 circadian regulation of gene expression GO:0032922 10.01 PER3 PER2 DRD2
3 acrosome reaction GO:0007340 9.88 GLRB GLRA1
4 adult walking behavior GO:0007628 9.88 DRD2 GLRA1 GLRB
5 response to iron ion GO:0010039 9.87 SLC6A3 DRD2
6 neuropeptide signaling pathway GO:0007218 9.86 GLRA1 GLRB HCRT HCRTR2
7 prepulse inhibition GO:0060134 9.85 SLC6A3 DRD2
8 righting reflex GO:0060013 9.81 GLRA1 GLRB
9 adenohypophysis development GO:0021984 9.8 SLC6A3 DRD2
10 hyaloid vascular plexus regression GO:1990384 9.78 SLC6A3 DRD2
11 dopamine uptake involved in synaptic transmission GO:0051583 9.76 SLC6A3 DRD2
12 excitatory postsynaptic potential GO:0060079 9.76 HCRT GLRB GLRA1 DRD2
13 negative regulation of transmission of nerve impulse GO:0051970 9.73 HCRT GLRA1
14 feeding behavior GO:0007631 9.67 HCRTR2 HCRT DRD2
15 nitrogen compound transport GO:0071705 9.56 SLC6A5 SLC6A3
16 neurotransmitter uptake GO:0001504 9.52 SLC6A5 SLC6A3
17 startle response GO:0001964 9.35 GLRB GLRA1 DRD2
18 synaptic transmission, glycinergic GO:0060012 9.1 SLC6A5 GLRB GLRA1

Molecular functions related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heterocyclic compound binding GO:1901363 9.56 SLC6A3 DRD2
2 glycine binding GO:0016594 9.46 GLRB GLRA1
3 dopamine binding GO:0035240 9.26 SLC6A3 DRD2
4 extracellularly glycine-gated chloride channel activity GO:0016934 8.92 GLRB GLRA1

Sources for Periodic Limb Movement Disorder

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....