MCID: PRD002
MIFTS: 33

Periodic Limb Movement Disorder

Categories: Mental diseases

Aliases & Classifications for Periodic Limb Movement Disorder

MalaCards integrated aliases for Periodic Limb Movement Disorder:

Name: Periodic Limb Movement Disorder 12 73 54 15 17
Nocturnal Myoclonus Syndrome 44 70
Nocturnal Myoclonus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9207
ICD9CM 34 327.51
MeSH 44 D020189
SNOMED-CT 67 418763003
ICD10 32 G47.61
UMLS 70 C0751774

Summaries for Periodic Limb Movement Disorder

Disease Ontology : 12 A sleep disorder that involves involuntary limb movement during sleep.

MalaCards based summary : Periodic Limb Movement Disorder, also known as nocturnal myoclonus syndrome, is related to restless legs syndrome and sleep disorder. An important gene associated with Periodic Limb Movement Disorder is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Circadian rythm related genes and Ligand-gated ion channel transport. The drugs Iron and Iron Supplement have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, eye and globus pallidus, and related phenotype is muscle.

Wikipedia : 73 Periodic limb movement disorder (PLMD) is a sleep disorder where the patient moves limbs involuntarily... more...

Related Diseases for Periodic Limb Movement Disorder

Diseases related to Periodic Limb Movement Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 restless legs syndrome 31.8 SKOR1 HCRT DRD2 BTBD9
2 sleep disorder 31.0 HCRTR2 HCRT BTBD9
3 narcolepsy 30.4 HCRTR2 HCRT DRD2
4 stiff-person syndrome 30.1 GLRB GLRA1
5 hyperekplexia 29.8 SLC6A5 GLRB GLRA1
6 sleep apnea 10.6
7 attention deficit-hyperactivity disorder 10.4
8 apnea, obstructive sleep 10.3
9 iron metabolism disease 10.3
10 hypersomnia 10.3
11 polyneuropathy 10.2
12 uremia 10.2
13 movement disease 10.2
14 rem sleep behavior disorder 10.2
15 phobic disorder 10.1 GLRB DRD2
16 rohhad 10.1 HCRTR2 HCRT
17 hyperekplexia 3 10.1 SLC6A5 GLRA1
18 von economo's disease 10.1 HCRTR2 HCRT
19 delayed sleep phase disorder 10.1
20 spinal disease 10.1
21 venous insufficiency 10.1
22 generalized anxiety disorder 10.1
23 epilepsy 10.1
24 focal epilepsy 10.1
25 somatoform disorder 10.1
26 fibromyalgia 10.1
27 chronic fatigue syndrome 10.1
28 myoclonus 10.1
29 bruxism 10.1 HCRT DRD2
30 advanced sleep phase syndrome 10.0 HCRTR2 HCRT BTBD9
31 cardiac arrhythmia 9.9
32 dystonia 11, myoclonic 9.9
33 jumping frenchmen of maine 9.9
34 polyradiculoneuropathy 9.9
35 chronic inflammatory demyelinating polyradiculoneuropathy 9.9
36 peripheral nervous system disease 9.9
37 neuropathy 9.9
38 central sleep apnea 9.9 ZSWIM1 ZNF221 MIR3157 HCRT
39 migraine with or without aura 1 9.7 HCRTR2 HCRT DRD2
40 benign epilepsy with centrotemporal spikes 8.7 ZSWIM1 ZNF221 MIR6134 MIR5186 MIR4537 MIR3157

Graphical network of the top 20 diseases related to Periodic Limb Movement Disorder:



Diseases related to Periodic Limb Movement Disorder

Symptoms & Phenotypes for Periodic Limb Movement Disorder

MGI Mouse Phenotypes related to Periodic Limb Movement Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.1 DRD2 GLRA1 GLRB HCRT HCRTR2 SLC6A5

Drugs & Therapeutics for Periodic Limb Movement Disorder

Drugs for Periodic Limb Movement Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925 29936
2 Iron Supplement Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Frequency and Timing of Oral Iron Administration for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder Enrolling by invitation NCT04610827 Phase 4 Ferrous sulfate
2 Consequences of Post Stroke Polysomnographic Abnormalities on Functionnal Recovery and Survival After an Ischemic Stroke Completed NCT04816136
3 Examining the Link Between Clinical and Physiological Sleep Data and Health-related Outcomes Active, not recruiting NCT03383354
4 Periodic Limb Movement Syndrome in Patients With Cerebral Small Vessel Disease: a Clinical and Neuropsychological Study. Enrolling by invitation NCT04569643
5 Periodic Leg Movement's Diagnosis in Spinal Cord Injury: Actigraphy as an Alternative for Polysomnography? Not yet recruiting NCT04618978
6 The Association Between Sleep Duration and Sleep Disorders and Proteinuria in Children Not yet recruiting NCT03933046

Search NIH Clinical Center for Periodic Limb Movement Disorder

Cochrane evidence based reviews: nocturnal myoclonus syndrome

Genetic Tests for Periodic Limb Movement Disorder

Anatomical Context for Periodic Limb Movement Disorder

MalaCards organs/tissues related to Periodic Limb Movement Disorder:

40
Spinal Cord, Eye, Globus Pallidus

Publications for Periodic Limb Movement Disorder

Articles related to Periodic Limb Movement Disorder:

(show top 50) (show all 284)
# Title Authors PMID Year
1
Lamotrigine in the treatment of nocturnal myoclonus syndrome (NMS): two case reports. 61 54
8739847 1996
2
Single photon emission tomography (SPET) imaging of dopamine D2 receptors in the course of dopamine replacement therapy in patients with nocturnal myoclonus syndrome (NMS). 54 61
8579804 1995
3
Nocturnal myoclonus syndrome (periodic movements in sleep) related to central dopamine D2-receptor alteration. 61 54
7786913 1995
4
Clinical manifestations and polysomnography-based analysis in nine cases of probable sporadic Creutzfeldt-Jakob disease. 61
33559029 2021
5
Restless sleep disorder, restless legs syndrome, and periodic limb movement disorder-Sleep in motion! 61
33527761 2021
6
Prevalence of sleep disorders among medical students of Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. 61
33575230 2020
7
Prevalence of narcolepsy and other sleep disorders and frequency of diagnostic tests from 2013-2016 in insured patients actively seeking care. 61
32807293 2020
8
Nocturnal eye movements in patients with idiopathic rapid eye movement sleep behaviour disorder and patients with Parkinson's disease. 61
32860309 2020
9
Overview of sleep disturbances and their management in Parkinson plus disorders. 61
32446010 2020
10
Sleep-Wake Disorders in Childhood. 61
32756235 2020
11
Not what it seems to be: Depression versus periodic limb movement disorder. 61
33165358 2020
12
Retrospective Analysis of Risk Factors for Periodic Limb Movements in a Large Cohort of Insomnia and Chronic Fatigue Patients. 61
31454848 2020
13
Utility of the Sleep Disorders Inventory for Students in Clinically Referred Youth With Insomnia: Risk Identification and Relationship With Polysomnographic Measures. 61
30793972 2020
14
High prevalence of periodic limb movements of sleep in children with Down syndrome. 61
31992397 2020
15
Subjective and objective features of sleep disorders in patients with acute ischemic or haemorrhagic stroke: It is not only sleep apnoea which is important. 61
31837521 2020
16
Comorbidities in children with elevated periodic limb movement index during sleep. 61
31555831 2020
17
Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review. 61
31678660 2019
18
Clinical presentation, diagnosis and polysomnographic findings in children with migraine referred to sleep clinics. 61
31606650 2019
19
Objective measures of sleep disturbances in children with Potocki-Lupski syndrome. 61
31342617 2019
20
Can body position and sleep stages influence motor patterns in periodic limb movement disorder? 61
31526968 2019
21
How does one choose the correct pharmacotherapy for a pediatric patient with restless legs syndrome and periodic limb movement disorder?: Expert Guidance. 61
31177869 2019
22
Sleep and Limb Movement Characteristics of Children With Atopic Dermatitis Coincidentally Undergoing Clinical Polysomnography. 61
31482832 2019
23
Validation of the REM sleep behavior disorder screening questionnaire in the Czech population. 61
31164104 2019
24
Improvement of Parasomnias After Treatment of Restless Leg Syndrome/ Periodic Limb Movement Disorder in Children. 61
31053208 2019
25
Ullanlinna Narcolepsy Scale in diagnosis of narcolepsy. 61
30476331 2019
26
Sleep Disorders. 61
30292731 2019
27
Confirmatory factor analysis of the SLEEP-50 Questionnaire in Trichotillomania (Hair-Pulling Disorder) and Excoriation (Skin-Picking) Disorder. 61
30654305 2019
28
Depression is differently associated with sleep measurement in obstructive sleep apnea, restless leg syndrome and periodic limb movement disorder. 61
30639562 2019
29
Polysomnography. 61
31277862 2019
30
Validation of a new data-driven automated algorithm for muscular activity detection in REM sleep behavior disorder. 61
30468824 2019
31
Subjective and objective assessments of sleep problems in children with attention deficit/hyperactivity disorder and the effects of methylphenidate treatment. 61
30709577 2018
32
Comparison of computerized methods for rapid eye movement sleep without atonia detection. 61
30011023 2018
33
Sleeping chILD: Neuroendocrine cell hyperplasia of infancy and polysomnography. 61
29766677 2018
34
Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline. 61
29991437 2018
35
Probabilistic Data-Driven Method for Limb Movement Detection during Sleep. 61
30440364 2018
36
Sleep disorders in the elderly: a growing challenge. 61
29878472 2018
37
The impact of sleep disorders on driving safety-findings from the Second Strategic Highway Research Program naturalistic driving study. 61
29408974 2018
38
Sleep patterns among patients with chronic fatigue: A polysomnography-based study. 61
28752613 2018
39
Sleep Disorders and Their Management in Children With Ehlers-Danlos Syndrome Referred to Sleep Clinics. 61
29609717 2018
40
Pharmacological Management of Restless Legs Syndrome and Periodic Limb Movement Disorder in Children. 61
28831753 2018
41
Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. 61
29425576 2018
42
The first night effect in multiple sclerosis patients undergoing home-based polysomnography. 61
30498381 2018
43
Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder. 61
29780335 2018
44
Quality of Sleep and Sleep Disorders in Patients with Parkinsonism: A Polysomnography Based Study from Rural South India. 61
29456351 2018
45
Attention deficit hyperactivity disorder symptom severity and sleep problems in adult participants of the Netherlands sleep registry. 61
29221785 2017
46
Idiopathic REM sleep behavior disorder in the elderly Spanish community: a primary care center study with a two-stage design using video-polysomnography. 61
29042180 2017
47
Sleep-dependent motor sequence memory consolidation in individuals with periodic limb movements. 61
29221774 2017
48
European guideline for the diagnosis and treatment of insomnia. 61
28875581 2017
49
[Sleep apnoea-hypopnoea syndrome and narcolepsy. Description of a series of hospital patients]. 61
28929470 2017
50
Restless Legs Syndrome and Sleep-Related Movement Disorders. 61
28777173 2017

Variations for Periodic Limb Movement Disorder

Expression for Periodic Limb Movement Disorder

Search GEO for disease gene expression data for Periodic Limb Movement Disorder.

Pathways for Periodic Limb Movement Disorder

Pathways related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2
Show member pathways
10.58 GLRB GLRA1

GO Terms for Periodic Limb Movement Disorder

Cellular components related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.56 SKOR1 GLRB GLRA1 DRD2
2 synapse GO:0045202 9.55 HCRTR2 HCRT GLRB GLRA1 DRD2
3 chloride channel complex GO:0034707 9.32 GLRB GLRA1
4 integral component of presynaptic membrane GO:0099056 9.13 SLC6A5 GLRA1 DRD2
5 glycinergic synapse GO:0098690 8.8 SLC6A5 GLRB GLRA1

Biological processes related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.65 SLC6A5 HCRTR2 HCRT GLRB GLRA1
2 neuropeptide signaling pathway GO:0007218 9.62 HCRTR2 HCRT GLRB GLRA1
3 feeding behavior GO:0007631 9.58 HCRTR2 HCRT DRD2
4 response to amino acid GO:0043200 9.54 GLRB GLRA1
5 adult walking behavior GO:0007628 9.54 GLRB GLRA1 DRD2
6 long-term memory GO:0007616 9.52 DRD2 BTBD9
7 neuromuscular process GO:0050905 9.51 GLRB GLRA1
8 temperature homeostasis GO:0001659 9.49 HCRT DRD2
9 acrosome reaction GO:0007340 9.48 GLRB GLRA1
10 righting reflex GO:0060013 9.46 GLRB GLRA1
11 negative regulation of transmission of nerve impulse GO:0051970 9.43 HCRT GLRA1
12 startle response GO:0001964 9.33 GLRB GLRA1 DRD2
13 excitatory postsynaptic potential GO:0060079 9.26 HCRT GLRB GLRA1 DRD2
14 synaptic transmission, glycinergic GO:0060012 8.8 SLC6A5 GLRB GLRA1

Molecular functions related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular ligand-gated ion channel activity GO:0005230 9.32 GLRB GLRA1
2 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 9.26 GLRB GLRA1
3 glycine binding GO:0016594 9.16 GLRB GLRA1
4 extracellularly glycine-gated chloride channel activity GO:0016934 8.96 GLRB GLRA1
5 extracellularly glycine-gated ion channel activity GO:0016933 8.62 GLRB GLRA1

Sources for Periodic Limb Movement Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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