MCID: PRD002
MIFTS: 41

Periodic Limb Movement Disorder

Categories: Mental diseases

Aliases & Classifications for Periodic Limb Movement Disorder

MalaCards integrated aliases for Periodic Limb Movement Disorder:

Name: Periodic Limb Movement Disorder 12 76 55 15
Nocturnal Myoclonus Syndrome 44 73
Nocturnal Myoclonus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9207
ICD10 33 G47.61
ICD9CM 35 327.51
MeSH 44 D020189
UMLS 73 C0751774

Summaries for Periodic Limb Movement Disorder

Disease Ontology : 12 A sleep disorder that involves involuntary limb movement during sleep.

MalaCards based summary : Periodic Limb Movement Disorder, also known as nocturnal myoclonus syndrome, is related to apnea, obstructive sleep and attention deficit-hyperactivity disorder. An important gene associated with Periodic Limb Movement Disorder is GLRA1 (Glycine Receptor Alpha 1), and among its related pathways/superpathways are Circadian rythm related genes and cAMP signaling pathway. The drugs Acetylcholine and onabotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and globus pallidus, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Periodic limb movement disorder (PLMD), or periodic limb movements in sleep (PLMS), previously known as... more...

Related Diseases for Periodic Limb Movement Disorder

Diseases related to Periodic Limb Movement Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 apnea, obstructive sleep 30.0 CTNNBL1 FXYD1 HTR2A
2 attention deficit-hyperactivity disorder 29.9 DRD2 HTR1A HTR2A HTR2C SLC6A4
3 restless legs syndrome 11.5
4 sleep apnea 10.4
5 myoclonus 10.3
6 tic disorder 10.3 DRD2 HTR2A
7 early-onset schizophrenia 10.2 DRD2 HTR2A
8 sexual disorder 10.2 HTR1A SLC6A4
9 tardive dyskinesia 10.2 DRD2 HTR2A
10 schizoid personality disorder 10.2 HTR1A HTR2A
11 hypoactive sexual desire disorder 10.2 HTR1A HTR2A
12 alcohol-induced mental disorder 10.2 DRD2 SLC6A4
13 atypical depressive disorder 10.2 HTR2A SLC6A4
14 neuroleptic malignant syndrome 10.2 DRD2 HTR1A
15 oppositional defiant disorder 10.1 DRD2 SLC6A4
16 dysthymic disorder 10.1 HTR2A SLC6A4
17 phobic disorder 10.1 HTR1A SLC6A4
18 kleptomania 10.1 HTR1A SLC6A4
19 substance-induced psychosis 10.1 DRD2 HTR1A HTR2A
20 drug-induced mental disorder 10.1 DRD2 HTR1A HTR2A
21 drug psychosis 10.1 DRD2 HTR1A HTR2A
22 alcoholic psychosis 10.1 DRD2 HTR2A SLC6A4
23 eating disorder 10.1 DRD2 HTR2C SLC6A4
24 pathological gambling 10.1 DRD2 HTR2A SLC6A4
25 migraine with aura 10.1 DRD2 HTR2C SLC6A4
26 social phobia 10.1 DRD2 HTR1A SLC6A4
27 intermittent explosive disorder 10.1 HTR1A SLC6A4
28 post-traumatic stress disorder 10.1 DRD2 HTR2A SLC6A4
29 restless legs syndrome 6 10.1
30 alexithymia 10.1 DRD2 HTR1A SLC6A4
31 schizoaffective disorder 10.1 DRD2 HTR2A SLC6A4
32 migraine without aura 10.1 DRD2 HTR1A SLC6A4
33 premature ejaculation 10.1 HTR1A HTR2C SLC6A4
34 agoraphobia 10.1 HTR1A SLC6A4
35 alcohol abuse 10.1 DRD2 HTR2A SLC6A4
36 bruxism 10.1 DRD2 HTR2A
37 tobacco addiction 10.1 DRD2 HTR2A SLC6A4
38 brunner syndrome 10.1 HTR1A SLC6A4
39 fibromyalgia 10.1 HTR2A SLC6A4
40 serotonin syndrome 10.1 HTR1A HTR2A SLC6A4
41 endogenous depression 10.1 HTR1A HTR2A SLC6A4
42 chronic fatigue syndrome 10.0 HTR1A HTR2A SLC6A4
43 antisocial personality disorder 10.0 DRD2 SLC6A4
44 auditory agnosia 10.0 CTNNBL1 KANTR
45 sudden infant death syndrome 10.0 HTR1A HTR2A SLC6A4
46 generalized anxiety disorder 10.0 DRD2 HTR1A HTR2A SLC6A4
47 psychosexual disorder 10.0 HTR1A HTR2A HTR2C SLC6A4
48 borderline personality disorder 10.0 HTR1A HTR2A HTR2C SLC6A4
49 bipolar i disorder 10.0 HTR1A HTR2A HTR2C SLC6A4
50 mental depression 10.0 HTR1A HTR2A HTR2C SLC6A4

Graphical network of the top 20 diseases related to Periodic Limb Movement Disorder:



Diseases related to Periodic Limb Movement Disorder

Symptoms & Phenotypes for Periodic Limb Movement Disorder

GenomeRNAi Phenotypes related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

26 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.84 FXYD1 HTR2C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.84 HTR2C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.84 HTR2C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.84 CTNNBL1 DRD2 FXYD1 HTR2C SLC6A4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.84 CTNNBL1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.84 FXYD1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.84 CTNNBL1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.84 DRD2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.84 CTNNBL1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.84 DRD2 FXYD1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.84 CTNNBL1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.84 SLC6A4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.84 DRD2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.84 HTR2C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.84 SLC6A4
16 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.84 FXYD1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.84 FXYD1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.84 CTNNBL1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.84 FXYD1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.84 DRD2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.84 DRD2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.84 SLC6A4
23 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.84 HTR2C
24 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.84 HTR2C
25 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.84 DRD2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.84 SLC6A4
27 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.84 CTNNBL1

MGI Mouse Phenotypes related to Periodic Limb Movement Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 DRD2 GLRA1 HTR1A HTR2A HTR2C PER1
2 muscle MP:0005369 9.56 DRD2 FXYD1 GLRA1 HTR2A HTR2C SLC6A4
3 taste/olfaction MP:0005394 8.8 DRD2 TP63 ZEB1

Drugs & Therapeutics for Periodic Limb Movement Disorder

Drugs for Periodic Limb Movement Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 onabotulinumtoxinA Phase 4
3 Botulinum Toxins Phase 4
4 Botulinum Toxins, Type A Phase 4
5 Cholinergic Agents Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 abobotulinumtoxinA Phase 4
9 Acetylcholine Release Inhibitors Phase 4
10 Neuromuscular Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
2 Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome in End Stage Renal Disease Patients Completed NCT01860209 Not Applicable
3 Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx) Completed NCT02020642 Not Applicable
4 Sleep Disturbance in Patients With End-Stage Renal Disease Recruiting NCT02583347
5 Effect of Beginning a Renal Replacement Therapy on Obstructive Sleep Apnea in End Stage Renal Disease Patients Recruiting NCT02073344 Not Applicable
6 The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes Recruiting NCT03383354

Search NIH Clinical Center for Periodic Limb Movement Disorder

Cochrane evidence based reviews: nocturnal myoclonus syndrome

Genetic Tests for Periodic Limb Movement Disorder

Anatomical Context for Periodic Limb Movement Disorder

MalaCards organs/tissues related to Periodic Limb Movement Disorder:

41
Testes, Brain, Globus Pallidus

Publications for Periodic Limb Movement Disorder

Articles related to Periodic Limb Movement Disorder:

(show top 50) (show all 77)
# Title Authors Year
1
Pharmacological Management of Restless Legs Syndrome and Periodic Limb Movement Disorder in Children. ( 28831753 )
2017
2
Should oral iron be first-line therapy for pediatric restless legs syndrome and periodic limb movement disorder? ( 28279575 )
2017
3
Periodic Limb Movements During Sleep Mimicking REM Sleep Behavior Disorder: A New Form of Periodic Limb Movement Disorder. ( 28364416 )
2017
4
While Isolated Periodic Limb Movement Disorder Significantly Impacts Sleep Depth and Efficiency, Co-Morbid Restless Leg Syndrome Mainly Exacerbates Perceived Sleep Quality. ( 28391285 )
2017
5
Obstructive sleep apnea and periodic limb movement disorder in a population of children with hypertension and/or nocturnal nondipping blood pressures. ( 26725017 )
2016
6
Outcomes of long-term iron supplementation in pediatric restless legs syndrome/periodic limb movement disorder (RLS/PLMD). ( 27282843 )
2016
7
Rotigotine effect on sleep in a de novo Parkinson's Disease patient affected by periodic limb movement disorder. ( 26578038 )
2015
8
The validity of the PAM-RL device for evaluating periodic limb movements in sleep and an investigation on night-to-night variability of periodic limb movements during sleep in patients with restless legs syndrome or periodic limb movement disorder using this system. ( 24269130 )
2014
9
Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy. ( 25667887 )
2014
10
Relationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome. ( 25008988 )
2014
11
Bilateral globus pallidus internus deep brain stimulation in Parkinson's disease with periodic limb movement disorder. ( 23344876 )
2013
12
Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose. ( 23993871 )
2013
13
Night-to-night variability of periodic leg movements during sleep in restless legs syndrome and periodic limb movement disorder: comparison between the periodicity index and the PLMS index. ( 23068780 )
2013
14
Impaired driving simulation in patients with Periodic Limb Movement Disorder and patients with Obstructive Sleep Apnea Syndrome. ( 22353445 )
2012
15
Update to the AASM Clinical Practice Guideline: "The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses". ( 22851800 )
2012
16
Clinical Inquiry. What drugs are effective for periodic limb movement disorder? ( 22577635 )
2012
17
The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. ( 22851801 )
2012
18
Pediatric periodic limb movement disorder: sleep symptom and polysomnographic correlates compared to obstructive sleep apnea. ( 22171198 )
2011
19
Restless legs syndrome, periodic leg movements, and periodic limb movement disorder in children. ( 21600344 )
2011
20
Ropinirole in restless legs syndrome and periodic limb movement disorder. ( 20421915 )
2010
21
All the wrong moves: a clinical review of restless legs syndrome, periodic limb movements of sleep and wake, and periodic limb movement disorder. ( 20488295 )
2010
22
Behavioral Sleep Medicine Interventions for Restless Legs Syndrome and Periodic Limb Movement Disorder. ( 20161553 )
2009
23
Pediatric restless legs syndrome and periodic limb movement disorder: parent-child pairs. ( 19332386 )
2009
24
Parents of children with periodic limb movement disorder versus sleep-disordered breathing report greater daytime mood and behavior difficulties in their child: the importance of using ICSD-2nd Edition criteria to define a PLMD study group. ( 19568964 )
2009
25
Periodic leg movements during sleep and periodic limb movement disorder in patients presenting with unexplained insomnia. ( 19109055 )
2009
26
Restless legs syndrome and periodic limb movement disorder in children and adolescents. ( 18555195 )
2008
27
Periodic limb movements in sleep and periodic limb movement disorder. ( 17235435 )
2007
28
EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep. ( 16987157 )
2006
29
Periodic limb movement disorder in children. ( 16798596 )
2006
30
Selected sleep disorders: restless legs syndrome and periodic limb movement disorder, sleep apnea syndrome, and narcolepsy. ( 17118276 )
2006
31
Periodic leg movements in sleep and periodic limb movement disorder: prevalence, clinical significance and treatment. ( 16762807 )
2006
32
Periodic limb movement disorder: an unusual mechanism of twiddling and potential benefit from cardiac resynchronization therapy. ( 15733189 )
2005
33
Abnormal H-reflexes in periodic limb movement disorder; impact on understanding the pathophysiology of the disorder. ( 15589198 )
2005
34
An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. ( 15164915 )
2004
35
Periodic limb movement disorder and restless legs syndrome in dialysis patients. ( 15663636 )
2004
36
Restless legs syndrome and periodic limb movement disorder. ( 15087209 )
2004
37
The restless legs syndrome and periodic limb movement disorder: a review of management. ( 15449218 )
2004
38
Activity patterns of leg muscles in periodic limb movement disorder. ( 14742617 )
2004
39
SLEEP year in review 2003--insomnia, sleep in psychiatric disorders, periodic limb movement disorder/restless legs syndrome, sleep in medical disorders. ( 15532215 )
2004
40
Restless legs syndrome and periodic limb movement disorder in the elderly. ( 15172211 )
2004
41
Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. ( 15164914 )
2004
42
Can periodic limb movement disorder be diagnosed without polysomnography? A case-control study. ( 14592358 )
2003
43
Cognitive and behavioral anomalies among insomnia patients with mixed restless legs and periodic limb movement disorder. ( 15600136 )
2003
44
The KickStrip: a novel testing device for periodic limb movement disorder. ( 12841376 )
2003
45
Different sleep characteristics in restless legs syndrome and periodic limb movement disorder. ( 14592346 )
2003
46
Periodic limb movement disorder of sleep in children. ( 12603789 )
2003
47
Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. ( 12127170 )
2002
48
EEG mapping, psychometric, and polysomnographic studies in restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) patients as compared with normal controls. ( 14592166 )
2002
49
Clinical symptomatology and treatment of restless legs syndrome and periodic limb movement disorder. ( 12531131 )
2002
50
Subjective sleep quality and suggested immobilization test in restless leg syndrome and periodic limb movement disorder. ( 12047601 )
2002

Variations for Periodic Limb Movement Disorder

Expression for Periodic Limb Movement Disorder

Search GEO for disease gene expression data for Periodic Limb Movement Disorder.

Pathways for Periodic Limb Movement Disorder

GO Terms for Periodic Limb Movement Disorder

Cellular components related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 DRD2 FXYD1 GLRA1 HTR1A HTR2A HTR2C
2 dendrite GO:0030425 9.43 DRD2 GLRA1 HTR1A HTR2A HTR2C TP63
3 integral component of postsynaptic membrane GO:0099055 9.33 DRD2 HTR2A SLC6A4
4 integral component of presynaptic membrane GO:0099056 8.92 DRD2 GLRA1 HTR2A SLC6A4

Biological processes related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.76 DRD2 HTR2A HTR2C SLC6A4
2 aging GO:0007568 9.74 HAMP HTR2A TP63
3 chemical synaptic transmission GO:0007268 9.71 GLRA1 HTR1A HTR2A HTR2C
4 feeding behavior GO:0007631 9.6 DRD2 HTR2C
5 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.59 HTR1A HTR2A
6 adult walking behavior GO:0007628 9.58 DRD2 GLRA1
7 behavioral fear response GO:0001662 9.58 HTR1A HTR2C
8 response to light stimulus GO:0009416 9.56 DRD2 PER1
9 temperature homeostasis GO:0001659 9.55 DRD2 HTR2A
10 behavioral response to cocaine GO:0048148 9.54 DRD2 HTR2A
11 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.54 HTR1A HTR2A HTR2C
12 regulation of sodium ion transport GO:0002028 9.52 DRD2 PER1
13 response to iron ion GO:0010039 9.51 DRD2 HAMP
14 startle response GO:0001964 9.49 DRD2 GLRA1
15 vasoconstriction GO:0042310 9.48 HTR1A SLC6A4
16 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.43 DRD2 HTR2A
17 release of sequestered calcium ion into cytosol GO:0051209 9.43 DRD2 HTR2A HTR2C
18 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.32 HTR2A HTR2C
19 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.16 HTR2A HTR2C
20 behavior GO:0007610 9.13 HTR1A HTR2A HTR2C
21 serotonin receptor signaling pathway GO:0007210 8.8 HTR1A HTR2A HTR2C

Molecular functions related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.5 DRD2 HTR2A HTR2C
2 neurotransmitter receptor activity GO:0030594 9.43 HTR1A HTR2A HTR2C
3 G protein-coupled serotonin receptor activity GO:0004993 9.33 HTR1A HTR2A HTR2C
4 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 8.96 HTR2A HTR2C
5 serotonin binding GO:0051378 8.92 HTR1A HTR2A HTR2C SLC6A4

Sources for Periodic Limb Movement Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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