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MCID: PRD008
MIFTS: 66

Periodontitis

Categories: Oral diseases, Gastrointestinal diseases, Blood diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Periodontitis

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MalaCards integrated aliases for Periodontitis:

Name: Periodontitis 12 76 29 6 44 15 73
Chronic Pericementitis 12
Chronic Periodontitis 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:824
ICD10 33 K05.3
MeSH 44 D010518
NCIt 50 C34918
Sources

Summaries for Periodontitis

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MalaCards based summary : Periodontitis, also known as chronic pericementitis, is related to periodontitis, aggressive, 1 and periapical periodontitis, and has symptoms including halitosis, snoring and tenderness of gums. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1
The large non-coding RNA ANRIL,which is associated with atherosclerosis,periodontitis and several forms of cancer,regulates ADIPOR1,VAMP3 and C11ORF10.
Dysfunction Pattern: Expression [differentially expressed]), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Hyaluronic acid and Menthol have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and heart, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 76 Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the... more...

Sources

Related Diseases for Periodontitis

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Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 623)
# Related Disease Score Top Affiliating Genes
1 periodontitis, aggressive, 1 34.7 CTSC FPR1 IL1A MMP1 MMP8
2 periapical periodontitis 33.8 IL1B IL6 MMP8 TLR2 TNFRSF11B TNFSF11
3 periodontosis 33.6 CXCL8 MMP9 TLR4 TNFSF11
4 periodontitis, chronic 33.4 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
5 gingivitis 32.7 CXCL8 IL1A IL1B IL6 MMP8 MMP9
6 aggressive periodontitis 32.5 CTSC CXCL8 FPR1 IL10 IL1A IL1B
7 root resorption 31.5 IL1A IL1B TNFRSF11B TNFSF11
8 gingival overgrowth 31.3 IL1A MMP1 TIMP1
9 diabetes mellitus 31.0 CDKN2B-AS1 CRP IL1A IL1B IL6 TNF
10 familial mediterranean fever 31.0 CRP IL1B TNF
11 apnea, obstructive sleep 30.9 CRP IL6 TNF
12 ischemic heart disease 30.8 CRP IL6 TNF
13 aphthous stomatitis 30.7 IL10 IL1B IL6 TNF
14 sleep apnea 30.6 CRP CXCL8 IL6 TNF
15 spondyloarthropathy 1 30.6 CRP TNF TNFRSF11B
16 prostatitis 30.6 CXCL8 IL10 IL1B IL6 TNF
17 spondylitis 30.6 CRP IL6 TNF
18 osteoporosis 30.6 CRP IL1A IL1B IL6 TNF TNFRSF11B
19 pulpitis 30.6 CXCL8 IL1A IL1B IL6 MMP1 TNF
20 hematopoietic stem cell transplantation 30.6 IL10 IL6 TNF
21 coronary artery anomaly 30.6 CDKN2B-AS1 CRP IL6 MMP9 TNFRSF11B
22 peptic ulcer disease 30.6 CXCL8 IL10 IL1B TNF
23 autoimmune myocarditis 30.5 IL1B TNF
24 fasciitis 30.5 CXCL8 IL6 TNF
25 palindromic rheumatism 30.5 CRP IL1B TNF
26 osteoporotic fracture 30.5 IL6 TNFRSF11B
27 peripheral artery disease 30.5 CDKN2B-AS1 CRP IL6 TNFRSF11B
28 pyoderma 30.4 CXCL8 MMP1 TNF
29 esophagitis 30.4 CXCL8 IL1B IL6
30 adult-onset still's disease 30.4 CRP IL1B IL6 TNF
31 duodenal ulcer 30.4 CXCL8 IL1B TNF
32 aortic valve disease 2 30.3 CRP TNFRSF11B TNFSF11
33 cytomegalovirus infection 30.3 CXCL8 IL10 IL6 TNF
34 periodontal disease 30.3 CRP CTSC CXCL8 IL1A IL1B IL6
35 vascular disease 30.2 CRP IL6 MMP9 TNF TNFRSF11B
36 arthritis 30.1 CXCL8 IL10 IL1A IL1B IL6 MMP1
37 brucellosis 30.1 CRP CXCL8 IL10 IL6 TLR4 TNF
38 helicobacter pylori infection 30.1 CXCL8 IL10 IL1B TLR4 TNF
39 cerebrovascular disease 30.0 CRP IL6 MMP9 TNF
40 arteriosclerosis 30.0 CRP IL10 IL6 MMP9
41 arteries, anomalies of 30.0 CRP IL1B IL6 MMP9 TLR9 TNF
42 gingival disease 29.8 IL1B IL6 MMP1 MMP8 TIMP1
43 pulmonary emphysema 29.8 MMP1 MMP8 MMP9 TIMP1
44 bronchiectasis 29.6 CXCL8 MMP8 TLR2
45 common variable immunodeficiency 29.6 IL10 IL6 TLR9 TNF
46 psoriasis 29.5 CXCL8 IL10 IL1A IL1B IL6 TLR9
47 glucose metabolism disease 29.5 CRP IL1B IL6 TLR9 TNF
48 paracoccidioidomycosis 29.3 IL10 IL6 TLR2 TLR4 TNF
49 bacterial vaginosis 29.2 CXCL8 IL1A IL1B IL6 TLR2 TLR4
50 ulcerative colitis 29.2 CRP CXCL8 IL10 IL1B IL6 TLR4

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to Periodontitis
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Symptoms & Phenotypes for Periodontitis

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UMLS symptoms related to Periodontitis:


halitosis, snoring, tenderness of gums, leukorrhea, purulent discharge

MGI Mouse Phenotypes related to Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 MMP9 IL1A IL1B CRP CTSC IL6
2 immune system MP:0005387 10.3 IL1A IL1B CRP CTSC IL6 FPR1
3 hematopoietic system MP:0005397 10.28 MMP9 IL1A IL1B CTSC IL6 FPR1
4 cardiovascular system MP:0005385 10.2 MMP9 IL1A IL1B CRP IL6 IL10
5 integument MP:0010771 10.02 MMP9 IL1A IL1B CTSC IL6 IL10
6 neoplasm MP:0002006 9.93 IL1B TIMP1 IL6 IL10 MMP1 MMP8
7 limbs/digits/tail MP:0005371 9.8 MMP9 IL10 TNFSF11 TLR4 TIMP1 TNF
8 respiratory system MP:0005388 9.56 MMP9 IL6 IL10 TLR2 TNFSF11 TLR4
9 skeleton MP:0005390 9.32 MMP9 IL1B IL6 IL10 TLR2 TNFSF11
Sources

Drugs & Therapeutics for Periodontitis

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Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 367)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 9004-61-9 53477741
2
Menthol Approved Phase 4,Not Applicable,Early Phase 1 2216-51-5 16666
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Not Applicable 85721-33-1 2764
4
Azithromycin Approved Phase 4,Phase 2,Not Applicable 83905-01-5 55185 447043
5
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
6 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 22916-47-8 4189
8
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 443-48-1 4173
9 sodium fluoride Approved Phase 4,Phase 3,Not Applicable 7681-49-4
10
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
11
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 9552079 2713
12
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
13
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
14
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
15
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
16
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
17
Hexetidine Approved, Investigational Phase 4 141-94-6
18
Polyestradiol phosphate Approved Phase 4 28014-46-2
19
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
20
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
21
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
22
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
23
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
24
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
25
Zoledronic acid Approved Phase 4 118072-93-8 68740
26
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81103-11-9 84029
27
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 1 10118-90-8 5281021
28
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-78-2 2244
29
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088
30
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
31
Montelukast Approved Phase 4 158966-92-8 5281040
32
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Not Applicable 15687-27-1 3672
33
Edetic Acid Approved, Vet_approved Phase 4,Not Applicable 60-00-4, 62-33-9 6049
34
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
35
Povidone Approved Phase 4,Not Applicable 9003-39-8
36
Coal tar Approved Phase 4,Phase 3,Not Applicable 8007-45-2
37
Pentetic acid Approved Phase 4,Not Applicable 67-43-6
38
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
39
Testosterone Approved, Investigational Phase 4 58-22-0 6013
40
Methyltestosterone Approved Phase 4 58-18-4 6010
41
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
42
Testosterone enanthate Approved Phase 4 315-37-7 9416
43
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
44 Lycopene Approved, Investigational, Nutraceutical Phase 4,Phase 1,Phase 2 502-65-8 446925
45
Lactitol Investigational Phase 4 585-86-4 3871
46 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Fluorides Phase 4,Phase 3,Not Applicable
48 Risedronate Sodium Phase 4 115436-72-1
49 calcium channel blockers Phase 4
50 Fluoroquinolones Phase 4

Interventional clinical trials:

(show top 50) (show all 652)
# Name Status NCT ID Phase Drugs
1 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
2 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
3 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
4 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
5 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
6 Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
7 Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets Unknown status NCT02391974 Phase 4
8 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
9 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
10 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
11 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
12 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
13 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
14 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
15 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
16 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
17 Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis Completed NCT01034501 Phase 4
18 Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis Completed NCT02014532 Phase 4 Montelukast;Placebo
19 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
20 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
21 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
22 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis Completed NCT02794506 Phase 4 Propolis;Placebo
23 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed NCT02355977 Phase 4 minocycline
24 Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
25 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
26 Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis Completed NCT03419429 Phase 4 Simvastatin
27 Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
28 Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization Completed NCT00707369 Phase 4 Amoxicillin and Metronidazole;Placebo
29 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Completed NCT00297518 Phase 4
30 Moxifloxacin in Situ Gel to Treat Periodontal Pocket. Completed NCT02016157 Phase 4 Moxifloxacin
31 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
32 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
33 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
34 Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease Completed NCT02901743 Phase 4
35 Melatonin as an Adjunctive Therapy for Chronic Periodontitis. Completed NCT03368430 Phase 4 Placebo
36 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours Completed NCT02215460 Phase 4 FMS chlorhexidine rinse;FMS placebo rinse;FMS azithromycin tablets;FMS placebo tablets;QS azithromycin tablets;QS placebo tablets;QS chlorhexidine rinse;QS placebo rinse
37 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
38 Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
39 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling Completed NCT03498404 Phase 4
40 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
41 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
42 The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis Completed NCT02023840 Phase 4 metronidazole gel;placebo
43 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology Completed NCT02030470 Phase 4
44 EFFECT OF SELECTIVE COX-2 INHIBITOR (ETORICOXIB) ALONG WITH SCALING AND ROOT PLANING (SRP) ON CLINICAL PARAMETERS AND SALIVARY LEVEL OF SUPEROXIDE DISMUTASE IN CHRONIC GENERALIZED PERIODONTITIS A DOUBLE-BLIND, PLACEBO-CONTROLLED, DOUBLE-MASKED RANDOMIZED Completed NCT02149758 Phase 4 Etoricoxib
45 MTZ Plus AMX in the Treatment of Smokers and Non-smokers Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
46 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
47 A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
48 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin Completed NCT02641210 Phase 4 Albendazole
49 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4 Doxicicline
50 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4 Sodium alendronate

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: periodontitis

Sources

Genetic Tests for Periodontitis

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Genetic tests related to Periodontitis:

# Genetic test Affiliating Genes
1 Periodontitis 29
Sources

Anatomical Context for Periodontitis

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MalaCards organs/tissues related to Periodontitis:

41
Bone, Neutrophil, Heart, Testes, Endothelial, Kidney, Monocytes
Sources

Publications for Periodontitis

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Articles related to Periodontitis:

(show top 50) (show all 4734)
# Title Authors Year
1
Squamous Cell Carcinoma of the Gingiva Mimicking Periodontal Disease: A Diagnostic Challenge and Therapeutic Dilemma. ( 29447319 )
2018
2
Prevalence of Periodontitis and Soft Tissue Lesions among Human Immunodeficiency Virus-positive Patients on Antiretroviral Therapy in Raichur Taluk, Karnataka, India. ( 29358533 )
2018
3
Antimicrobial peptide gene expression in periodontitis patients: a pilot study. ( 29446150 )
2018
4
Fulminant presentation of oral mucosal leishmaniasis as severe stomatitis and periodontitis. ( 29380732 )
2018
5
Lipopolysaccharide can modify differentiation and immunomodulatory potential of periodontal ligament stem cells via ERK1,2 signaling. ( 28295277 )
2018
6
Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan. ( 29734656 )
2018
7
The immunopathogenic and immunomodulatory effects of interleukin-12 in periodontal disease. ( 29411897 )
2018
8
Effect of Initial Periodontal Therapy on Salivary Trefoil Factor (TFF3) in otherwise Healthy Patients with Gingivitis and Chronic Periodontitis. ( 29962757 )
2018
9
Discrepancy of Clinical Parameters between the First and Second Molars Can Help to Differentiate Subjects with Aggressive Periodontitis from Chronic Periodontitis: a Cross-sectional Study Based on a Large Chinese Population. ( 29808177 )
2018
10
Association between obstructive sleep apnea and comorbidities with periodontal disease in adults. ( 29962700 )
2018
11
Risk of colorectal cancer in patients with periodontal disease severity: a nationwide, population-based cohort study. ( 29397431 )
2018
12
Expression of Osteoprotegrin and Osteoclast Level in Chronic Apical Periodontitis Induced with East Java Propolis Extract. ( 29692834 )
2018
13
Diagnosis of aggressive periodontitis: A dilemma? ( 29363676 )
2018
14
Consanguinity increases the risk for aggressive periodontitis. ( 29947052 )
2018
15
Feasibility of using allograft bone with resorbable collagen membrane for alveolar ridge vertical defect augmentation for dental implant placement in Patient with Aggressive Periodontitis: A case report. ( 29942111 )
2018
16
The Subgingival Microbiome of Periodontal Pockets With Different Probing Depths in Chronic and Aggressive Periodontitis: A Pilot Study. ( 29765908 )
2018
17
Evaluating periodontal disease misclassification mechanisms under partial-mouth recording protocols. ( 29385644 )
2018
18
The effect of periodontal disease treatment in patients with continuous ambulatory peritoneal dialysis. ( 29926368 )
2018
19
Periodontal bacteria DNA findings in human cardiac tissue - Is there a link of periodontitis to heart valve disease? ( 29197463 )
2018
20
12 years' preservation of maxillary permanent incisors with cervical root fractures adjacent to aggressive periodontitis: Report of a case. ( 29786703 )
2018
21
Salivary and Serum Antioxidants in Women with Preeclampsia with or Without Periodontal Disease. ( 29391673 )
2018
22
Assessment of Lipid Peroxidation Levels and Total Antioxidant Status in Chronic and Aggressive Periodontitis Patients: An in vivo Study. ( 29603700 )
2018
23
<i>Porphyromonas gingivalis</i> , a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice. ( 29422938 )
2018
24
Association of Tumor Necrosis Factor-I+ (TNF-I+) Gene Promoter Polymorphisms with Aggressive and Chronic Periodontitis in Eastern Indian population. ( 29449347 )
2018
25
Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment. ( 28427824 )
2018
26
Periodontal disease: What nurses need to know. ( 29923917 )
2018
27
Antimicrobial activity of amixicile against treponema denticola and other oral spirochetes associated with periodontal disease. ( 29958324 )
2018
28
Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study. ( 29394286 )
2018
29
Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease -Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase. ( 29441048 )
2018
30
Analysis of metabolic profiles of generalized aggressive periodontitis. ( 29974463 )
2018
31
Management of localized aggressive periodontitis: A 30-year follow-up. ( 29930995 )
2018
32
Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis. ( 29980169 )
2018
33
B cell subset distribution is altered in patients with severe periodontitis. ( 29447240 )
2018
34
Definition of aggressive periodontitis in periodontal research. A systematic review. ( 29226356 )
2018
35
Clinical efficacy of subgingivally-delivered 0.75% boric acid gel as an adjunct to mechanotherapy in chronic periodontitis: A randomized, controlled clinical trial. ( 28474437 )
2018
36
Effect of a comprehensive plan for periodontal disease care on oral health-related quality of life in patients with periodontal disease in Taiwan. ( 29384859 )
2018
37
Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy. ( 29426362 )
2018
38
Methodological issues in assessing the association between periodontitis and caries among adolescents. ( 29446848 )
2018
39
Factors affecting periodontal disease referral and the adherence to guidelines among general dentists. ( 29947419 )
2018
40
Independent determinants of periodontitis in Yemeni adults: A case-control study. ( 29963753 )
2018
41
Severe periodontitis and higher cirrhosis mortality. ( 29435316 )
2018
42
Development, optimization and evaluation of curcumin loaded biodegradable crosslinked gelatin film for the effective treatment of periodontitis. ( 29429364 )
2018
43
Are cardiovascular risk parameters and glycemic levels associated with periodontitis in type 2 diabetes patients? A clinical study. ( 29961463 )
2018
44
Efficacy of local phytotherapy in the nonsurgical treatment of periodontal disease: A systematic review. ( 29352465 )
2018
45
Radiographic morphology of intrabony defects in the first molars of patients with localized aggressive periodontitis: Comparison with health and chronic periodontitis. ( 29660823 )
2018
46
Classification and diagnosis of aggressive periodontitis. ( 29926487 )
2018
47
Morphometric and histopathological evaluation of the effect of grape seed proanthocyanidin on alveolar bone loss in experimental diabetes and periodontitis. ( 29446089 )
2018
48
Dickkopf-1 may regulate bone coupling by attenuating wnt/I^-catenin signaling in chronic apical periodontitis. ( 29216526 )
2018
49
Periodontal disease and susceptibility to breast cancer: a meta-analysis of observational studies. ( 29974484 )
2018
50
Contribution of Diabetes to the Incidence and Prevalence of Comorbid Conditions (Cancer, Periodontal Disease, Fracture, Impaired Cognitive Function, and Depression): A Systematic Review of Epidemiological Studies in Japanese Populations. ( 29937469 )
2018
Sources

Variations for Periodontitis

About this section

ClinVar genetic disease variations for Periodontitis:

6
(show all 26)
# Gene Variation Type Significance SNP ID Assembly Location
1 FPR1 NM_002029.3(FPR1): c.993C> T (p.Thr331=) single nucleotide variant Benign rs17849971 GRCh38 Chromosome 19, 51746002: 51746002
2 FPR1 NM_002029.3(FPR1): c.993C> T (p.Thr331=) single nucleotide variant Benign rs17849971 GRCh37 Chromosome 19, 52249255: 52249255
3 FPR1 NM_002029.3(FPR1): c.488G> A (p.Arg163His) single nucleotide variant Benign rs111768566 GRCh38 Chromosome 19, 51746507: 51746507
4 FPR1 NM_002029.3(FPR1): c.488G> A (p.Arg163His) single nucleotide variant Benign rs111768566 GRCh37 Chromosome 19, 52249760: 52249760
5 FPR1 NM_002029.3(FPR1): c.306T> C (p.Phe102=) single nucleotide variant Benign rs28930680 GRCh38 Chromosome 19, 51746689: 51746689
6 FPR1 NM_002029.3(FPR1): c.306T> C (p.Phe102=) single nucleotide variant Benign rs28930680 GRCh37 Chromosome 19, 52249942: 52249942
7 FPR1 NM_002029.3(FPR1): c.26C> T (p.Thr9Met) single nucleotide variant Likely benign rs148095693 GRCh38 Chromosome 19, 51746969: 51746969
8 FPR1 NM_002029.3(FPR1): c.26C> T (p.Thr9Met) single nucleotide variant Likely benign rs148095693 GRCh37 Chromosome 19, 52250222: 52250222
9 FPR1 NM_002029.3(FPR1): c.348C> T (p.Ile116=) single nucleotide variant Benign rs5030879 GRCh37 Chromosome 19, 52249900: 52249900
10 FPR1 NM_002029.3(FPR1): c.348C> T (p.Ile116=) single nucleotide variant Benign rs5030879 GRCh38 Chromosome 19, 51746647: 51746647
11 FPR1 NM_002029.3(FPR1): c.177C> T (p.Val59=) single nucleotide variant Benign rs61736491 GRCh37 Chromosome 19, 52250071: 52250071
12 FPR1 NM_002029.3(FPR1): c.177C> T (p.Val59=) single nucleotide variant Benign rs61736491 GRCh38 Chromosome 19, 51746818: 51746818
13 FPR1 NM_002029.3(FPR1): c.1037_1038delAGinsCA (p.Glu346Ala) indel Benign GRCh38 Chromosome 19, 51745957: 51745958
14 FPR1 NM_002029.3(FPR1): c.1037_1038delAGinsCA (p.Glu346Ala) indel Benign GRCh37 Chromosome 19, 52249210: 52249211
15 FPR1 NM_002029.3(FPR1): c.827A> G (p.Tyr276Cys) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 52249421: 52249421
16 FPR1 NM_002029.3(FPR1): c.827A> G (p.Tyr276Cys) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 51746168: 51746168
17 FPR1 NM_002029.3(FPR1): c.806G> A (p.Arg269His) single nucleotide variant Benign rs142210016 GRCh37 Chromosome 19, 52249442: 52249442
18 FPR1 NM_002029.3(FPR1): c.806G> A (p.Arg269His) single nucleotide variant Benign rs142210016 GRCh38 Chromosome 19, 51746189: 51746189
19 FPR1 NM_002029.3(FPR1): c.674C> T (p.Ala225Val) single nucleotide variant Uncertain significance rs141913828 GRCh38 Chromosome 19, 51746321: 51746321
20 FPR1 NM_002029.3(FPR1): c.674C> T (p.Ala225Val) single nucleotide variant Uncertain significance rs141913828 GRCh37 Chromosome 19, 52249574: 52249574
21 FPR1 NM_002029.3(FPR1): c.289C> A (p.Leu97Met) single nucleotide variant Benign rs78488639 GRCh38 Chromosome 19, 51746706: 51746706
22 FPR1 NM_002029.3(FPR1): c.289C> A (p.Leu97Met) single nucleotide variant Benign rs78488639 GRCh37 Chromosome 19, 52249959: 52249959
23 FPR1 NM_002029.3(FPR1): c.645C> T (p.Ser215=) single nucleotide variant Benign rs35264765 GRCh38 Chromosome 19, 51746350: 51746350
24 FPR1 NM_002029.3(FPR1): c.645C> T (p.Ser215=) single nucleotide variant Benign rs35264765 GRCh37 Chromosome 19, 52249603: 52249603
25 FPR1 NM_002029.3(FPR1): c.117C> T (p.Leu39=) single nucleotide variant Benign rs149382837 GRCh37 Chromosome 19, 52250131: 52250131
26 FPR1 NM_002029.3(FPR1): c.117C> T (p.Leu39=) single nucleotide variant Benign rs149382837 GRCh38 Chromosome 19, 51746878: 51746878
Sources

Expression for Periodontitis

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Search GEO for disease gene expression data for Periodontitis.
Sources

Pathways for Periodontitis

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Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.98 CRP CTSC CXCL8 FPR1 IL10 IL1A
2
PEDF Induced Signaling 64
Show member pathways
 13.76 CXCL8 IL10 IL1A IL1B IL6 TIMP1
3
Akt Signaling 64
Show member pathways
 13.52 CXCL8 IL10 IL1A IL1B IL6 TIMP1
4
Cytokine Signaling in Immune system 66
Show member pathways
 13.44 CXCL8 FPR1 IL10 IL1A IL1B IL6
5
PAK Pathway 64
Show member pathways
 13.38 CXCL8 IL10 IL1A IL1B IL6 TIMP1
6
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.14 CXCL8 IL10 IL1B IL6 TLR2 TLR4
7
Allograft rejection 1 37
Show member pathways
 12.95 CXCL8 IL10 IL1A IL1B IL6 TNF
8
Influenza A 37
Show member pathways
 12.93 CXCL8 IL1A IL1B IL6 TLR2 TLR4
9
IL-2 Pathway 64
Show member pathways
 12.88 IL1A IL1B TLR2 TLR4 TLR9 TNF
10
NF-KappaB Family Pathway 64
Show member pathways
 12.84 IL1A IL1B IL6 TIMP1 TLR2 TLR4
11
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.81 CXCL8 IL1B IL6 TLR4 TNF
12
Regulation of IFNA signaling 66
Show member pathways
 12.77 CXCL8 IL10 IL1A IL1B IL6 TNF
13
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.7 CXCL8 IL6 MMP9 TLR2 TLR4 TNF
14
NF-kappaB Signaling 4
12.69 IL10 IL1B TLR2 TLR9 TNF TNFSF11
15
Immune response IL-23 signaling pathway 22
Show member pathways
 12.66 IL10 IL1B IL6 TIMP1 TNF
16
TRAF Pathway 64
Show member pathways
 12.66 IL1A IL1B TLR2 TLR4 TLR9 TNF
17
Th17 cell differentiation 37
Show member pathways
 12.59 IL10 IL1A IL1B IL6 TLR2 TLR4
18
T cell receptor signaling pathway 37
Show member pathways
 12.52 IL10 IL1A IL1B IL6 TNF
19
IL-17 Family Signaling Pathways 65
Show member pathways
 12.49 CXCL8 IL1B IL6 MMP1 MMP9 TLR2
20
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.43 CXCL8 IL1A IL6 TLR2 TLR4 TLR9
21
Toll Comparative Pathway 64
Show member pathways
 12.42 CXCL8 IL1A IL1B IL6 TLR4 TNF
22
Th1 Differentiation Pathway 65
Show member pathways
 12.42 IL10 IL1B IL6 TLR2 TLR4 TLR9
23
Toxoplasmosis 37
Show member pathways
 12.41 IL10 IL1A IL1B TLR2 TLR4 TNF
24
Folate Metabolism 1
Show member pathways
 12.38 CRP IL1B IL6 TNF
25
IL-1 Family Signaling Pathways 65
Show member pathways
 12.38 CXCL8 IL1A IL1B IL6 TLR2 TNF
26
Proteoglycans in cancer 37
12.35 MMP9 TLR2 TLR4 TNF
27
C-type lectin receptor signaling pathway 37
Show member pathways
 12.34 IL10 IL1B IL6 TLR9 TNF
28
Bacterial infections in CF airways 22
Show member pathways
 12.34 CXCL8 IL1B IL6 TLR2 TLR4 TLR9
29
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.33 CXCL8 IL10 IL1A IL1B IL6 TNF
30
Colorectal Cancer Metastasis 64
12.33 IL6 MMP1 MMP9 TLR2 TLR4 TLR9
31
Tuberculosis 37
12.31 IL10 IL1A IL1B IL6 TLR2 TLR4
32
Necroptosis 37
Show member pathways
 12.28 IL1A IL1B TLR4 TNF
33
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.2 CXCL8 IL10 IL1A IL1B IL6 TIMP1
34
Osteoclast differentiation 37
12.19 IL1A IL1B TNF TNFRSF11B TNFSF11
35
MAPK Pathway 72
Show member pathways
 12.18 IL1A IL1B TLR2 TLR4 TLR9
36
Fluid shear stress and atherosclerosis 37
12.17 IL1A IL1B MMP9 TNF
37
Spinal Cord Injury 1
12.15 CXCL8 IL1A IL1B IL6 MMP9 TLR4
38
AGE-RAGE signaling pathway in diabetic complications 37
12.07 CXCL8 IL1A IL1B IL6 TNF
39
Matrix Metalloproteinases 1
Show member pathways
 12.07 MMP1 MMP8 MMP9 TIMP1 TNF
40
TNF signaling pathway 37
12.05 IL1B IL6 MMP9 TNF
41
Senescence and Autophagy in Cancer 1
12.04 CXCL8 IL1A IL1B IL6
42
NF-kappa B signaling pathway 37
12.04 CXCL8 IL1B TLR4 TNF TNFSF11
43
Hematopoietic cell lineage 37
12 IL1A IL1B IL6 TNF
44
Salmonella infection (KEGG) 37
12 CXCL8 IL1A IL1B IL6 TLR4
45
Amoebiasis 37
12 CXCL8 IL10 IL1B IL6 TLR2 TLR4
46
Interleukin-4 and 13 signaling 66
11.97 CXCL8 IL10 IL1A IL1B IL6 MMP1
47
IL6-mediated signaling events 1
Show member pathways
 11.94 CRP IL6 TIMP1 TNFSF11
48
Dendritic Cells Developmental Lineage Pathway 65
11.91 IL10 IL1B IL6 TLR9 TNF
49
Phagocytosis of Microbes 64
11.86 TLR2 TLR4 TLR9
50
Glucocorticoid receptor regulatory network 1
11.84 CXCL8 IL6 MMP1
Sources

GO Terms for Periodontitis

About this section

Cellular components related to Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 CRP CTSC CXCL8 IL10 IL1A IL1B
2 extracellular space GO:0005615 9.47 CRP CTSC CXCL8 IL10 IL1A IL1B
3 extracellular matrix GO:0031012 9.46 MMP1 MMP8 MMP9 TIMP1

Biological processes related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.99 CXCL8 IL10 IL6 TLR4 TNF
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.97 IL10 IL1B IL6 TNF TNFSF11
3 activation of MAPK activity GO:0000187 9.96 FPR1 IL1B TLR4 TNF
4 response to organic substance GO:0010033 9.95 CTSC IL10 TIMP1 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.95 CRP IL6 TLR2 TNF
6 extracellular matrix disassembly GO:0022617 9.92 MMP1 MMP8 MMP9 TIMP1
7 apoptotic signaling pathway GO:0097190 9.91 TLR4 TNF TNFRSF11B
8 positive regulation of inflammatory response GO:0050729 9.91 TLR2 TLR4 TLR9
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 IL1B TLR2 TLR4 TLR9 TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL1B IL6 TLR2 TLR4 TLR9 TNF
11 response to glucocorticoid GO:0051384 9.9 IL10 IL6 TNF
12 collagen catabolic process GO:0030574 9.9 MMP1 MMP8 MMP9
13 positive regulation of tumor necrosis factor production GO:0032760 9.88 TLR2 TLR4 TLR9
14 positive regulation of JNK cascade GO:0046330 9.88 IL1A IL1B TLR4 TLR9 TNF TNFSF11
15 toll-like receptor signaling pathway GO:0002224 9.87 TLR2 TLR4 TLR9
16 positive regulation of interferon-gamma production GO:0032729 9.87 IL1B TLR4 TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 IL1B TLR4 TNF
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.86 IL1B TLR2 TLR4 TNF
19 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.85 IL10 MMP9 TNF
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.85 IL1A IL1B TNF
21 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.84 TLR2 TLR4 TLR9
22 negative regulation of interleukin-6 production GO:0032715 9.84 IL10 TLR4 TLR9 TNF
23 positive regulation of cytokine secretion GO:0050715 9.83 IL10 IL1A TNF
24 positive regulation of interferon-beta production GO:0032728 9.83 TLR2 TLR4 TLR9
25 positive regulation of interleukin-8 production GO:0032757 9.83 IL1B TLR2 TLR4 TLR9 TNF
26 positive regulation of interleukin-12 production GO:0032735 9.82 TLR2 TLR4 TLR9
27 positive regulation of interleukin-10 production GO:0032733 9.81 TLR2 TLR4 TLR9
28 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.79 TLR2 TLR4 TLR9
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 IL10 IL1B TNF
30 I-kappaB phosphorylation GO:0007252 9.78 TLR2 TLR4 TLR9
31 response to molecule of bacterial origin GO:0002237 9.78 CXCL8 IL10 TLR2 TLR9
32 regulation of cytokine secretion GO:0050707 9.77 TLR2 TLR4 TLR9
33 negative regulation of lipid storage GO:0010888 9.75 CRP IL6 TNF
34 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.74 IL1A IL1B
35 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.74 IL1A IL1B