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MCID: PRD008
MIFTS: 66

Periodontitis

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Periodontitis

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MalaCards integrated aliases for Periodontitis:

Name: Periodontitis 12 77 30 6 45 15 17 74
Chronic Pericementitis 12
Chronic Periodontitis 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:824
MeSH 45 D010518
NCIt 51 C34918
SNOMED-CT 69 41565005
ICD10 34 K05.3
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Summaries for Periodontitis

About this section
MalaCards based summary : Periodontitis, also known as chronic pericementitis, is related to periodontitis, chronic and periapical periodontitis, and has symptoms including snoring, halitosis and tenderness of gums. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs sodium fluoride and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the... more...

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Related Diseases for Periodontitis

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Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 803)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 34.0 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
2 periapical periodontitis 33.9 IL1B IL6 MMP8 TLR2 TNF TNFRSF11B
3 aggressive periodontitis 33.4 CTSC CXCL8 FPR1 IL10 IL1A IL1B
4 periodontosis 33.3 CXCL8 MMP9 TLR4 TNF TNFSF11
5 gingivitis 32.2 CXCL8 IL1A IL1B IL6 MMP8 MMP9
6 periodontal disease 32.1 CRP CTSC CXCL8 IL17A IL1A IL1B
7 bone resorption disease 31.6 IL6 TNFRSF11B TNFSF11
8 diabetes mellitus 31.5 CDKN2B-AS1 CRP IL1A IL1B IL6 TNF
9 osteoporosis 31.1 IL1A IL1B IL6 TNF TNFRSF11B TNFSF11
10 gingival overgrowth 31.1 IL1A IL6 MMP1 TIMP1
11 root resorption 31.1 IL1A IL1B TNFRSF11B TNFSF11
12 heart disease 31.0 CRP CXCL8 IL10 IL1B IL6 TNF
13 human immunodeficiency virus infectious disease 30.8 IL10 IL6 TNF
14 familial mediterranean fever 30.8 CRP IL1B TNF
15 arteries, anomalies of 30.7 CRP IL1B IL6 MMP9 TNF
16 end stage renal failure 30.6 CRP IL6 TNF
17 apnea, obstructive sleep 30.5 CRP IL6 TNF
18 ischemic heart disease 30.5 CRP IL6 TNF
19 arthritis 30.5 CXCL8 IL10 IL17A IL1A IL1B IL6
20 autoimmune myocarditis 30.5 IL6 TNF
21 vascular disease 30.4 CRP IL6 MMP9 TNF TNFRSF11B
22 spondylitis 30.4 CRP IL17A IL6 TNF
23 cerebral palsy 30.4 IL1B IL6 MMP8 TNF
24 pulpitis 30.4 CXCL8 IL1A IL1B IL6 MMP1 TNF
25 sleep apnea 30.4 CRP CXCL8 IL1B IL6 TNF
26 purpura 30.4 CRP IL6 TNF
27 fatty liver disease 30.4 CXCL8 IL1A IL1B IL6 TNF
28 juvenile rheumatoid arthritis 30.4 CRP IL1B IL6 TNF
29 atherosclerosis susceptibility 30.3 CDKN2B-AS1 CRP IL6 TLR4 TNF
30 hematopoietic stem cell transplantation 30.3 IL10 IL6 TNF
31 placenta disease 30.3 CXCL8 IL1B IL6
32 cytomegalovirus infection 30.3 CXCL8 IL1B IL6 TNF
33 aortic valve disease 2 30.3 CRP TNFRSF11B TNFSF11
34 autoimmune disease 30.2 IL10 IL17A IL1B IL6 TNF
35 leprosy 3 30.2 IL10 TLR2 TNF
36 acquired immunodeficiency syndrome 30.2 IL10 IL1B IL6 TNF
37 osteoporotic fracture 30.2 IL6 TNFRSF11B
38 endometriosis 30.2 CDKN2B-AS1 CXCL8 IL1B IL6
39 spondyloarthropathy 1 30.1 CRP IL17A TLR4 TNF TNFRSF11B
40 gingival disease 30.1 IL1A IL1B IL6 MMP1 MMP8 TIMP1
41 esophagitis 30.1 CXCL8 IL1B IL6
42 crohn's colitis 30.1 CXCL8 IL1B TNF
43 duodenal ulcer 30.1 CXCL8 IL1B TNF
44 palindromic rheumatism 30.1 CRP IL1B TNF
45 temporal arteritis 30.1 CRP IL6 TNF
46 fasciitis 30.1 CXCL8 IL6 TNF
47 myocardial infarction 30.0 CDKN2B-AS1 CRP IL10 IL1B IL6 MMP9
48 osteomyelitis 30.0 CXCL8 IL10 IL1A IL1B IL6 TNF
49 connective tissue disease 30.0 IL10 IL1A IL6 TNF
50 prostatitis 30.0 CXCL8 IL10 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to Periodontitis
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Symptoms & Phenotypes for Periodontitis

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UMLS symptoms related to Periodontitis:


snoring, halitosis, tenderness of gums, leukorrhea, purulent discharge

GenomeRNAi Phenotypes related to Periodontitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CXCL8 IL10 IL17A IL1A IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CXCL8 IL10 IL17A IL1A IL1B TNF

MGI Mouse Phenotypes related to Periodontitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 CRP CTSC FPR1 IL10 IL17A IL1A
2 immune system MP:0005387 10.3 CRP CTSC FPR1 IL10 IL17A IL1A
3 hematopoietic system MP:0005397 10.28 CTSC FPR1 IL10 IL17A IL1A IL1B
4 growth/size/body region MP:0005378 10.23 CTSC IL10 IL17A IL1B IL6 MMP9
5 cardiovascular system MP:0005385 10.22 CRP IL10 IL1A IL1B IL6 MMP9
6 integument MP:0010771 10.02 CTSC IL10 IL1A IL1B IL6 MMP9
7 neoplasm MP:0002006 9.93 IL10 IL1A IL1B IL6 MMP1 MMP8
8 limbs/digits/tail MP:0005371 9.8 IL10 MMP9 TIMP1 TLR4 TNF TNFRSF11B
9 respiratory system MP:0005388 9.61 IL10 IL17A IL6 MMP9 TIMP1 TLR2
10 skeleton MP:0005390 9.36 IL10 IL17A IL1B IL6 MMP9 TIMP1
Sources

Drugs & Therapeutics for Periodontitis

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Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 396)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 3,Not Applicable 7681-49-4
2
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 443-48-1 4173
3
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 26787-78-0 33613
4
Polyestradiol phosphate Approved Phase 4 28014-46-2
5
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
8
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
9
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 2713 9552079
10
Coal tar Approved Phase 4,Phase 3,Not Applicable 8007-45-2
11
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 9004-61-9 53477741
12
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
13
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
14
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
15
Hexetidine Approved, Investigational Phase 4 141-94-6
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 22916-47-8 4189
17
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
18
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Not Applicable 85721-33-1 2764
19
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 10118-90-8 5281021
20
Azithromycin Approved Phase 4,Phase 2,Not Applicable 83905-01-5 55185 447043
21
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-78-2 2244
22
Neomycin Approved, Vet_approved Phase 4,Not Applicable 1404-04-2 8378
23
Bacitracin Approved, Vet_approved Phase 4,Not Applicable 1405-87-4 439542 10909430
24
Polymyxin B Approved, Vet_approved Phase 4,Not Applicable 1404-26-8
25
Montelukast Approved Phase 4 158966-92-8 5281040
26
Turmeric Approved, Experimental, Investigational Phase 4,Not Applicable
27
Edetic Acid Approved, Vet_approved Phase 4,Not Applicable 62-33-9, 60-00-4 6049
28
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
29
Pentetic acid Approved Phase 4,Not Applicable 67-43-6
30
Triclosan Approved, Investigational Phase 4,Phase 3 3380-34-5 5564
31
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
32
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
33 Lycopene Approved, Investigational Phase 4,Phase 1,Phase 2 502-65-8 53477748
34
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 564-25-0 54671203
35
Alendronate Approved Phase 4,Phase 2,Phase 3 66376-36-1, 121268-17-5 2088
36
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 137-58-6 3676
37
Zoledronic Acid Approved Phase 4 118072-93-8 68740
38
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81103-11-9 84029
39
Atorvastatin Approved Phase 4,Phase 2,Phase 3 134523-00-5 60823
40
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Not Applicable 15687-27-1 3672
41
Acetaminophen Approved Phase 4,Phase 2,Not Applicable 103-90-2 1983
42
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
43
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
44
Povidone Approved Phase 4,Not Applicable 9003-39-8
45
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
46
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
47
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
48
Methyltestosterone Approved Phase 4 58-18-4 6010
49
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 6013 10204
50
Testosterone enanthate Approved Phase 4 315-37-7 9416

Interventional clinical trials:

(show top 50) (show all 756)
# Name Status NCT ID Phase Drugs
1 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
2 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
3 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
4 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
5 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
6 Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
7 Treatment of Periodontitis in Obese Individuals Unknown status NCT03103204 Phase 4
8 Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets Unknown status NCT02391974 Phase 4
9 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
10 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
11 Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
12 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
13 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
14 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
15 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
16 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
17 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
18 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
19 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
20 Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis Completed NCT01034501 Phase 4
21 Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis Completed NCT02014532 Phase 4 Montelukast;Placebo
22 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
23 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
24 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
25 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis Completed NCT02794506 Phase 4 Propolis;Placebo
26 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed NCT02355977 Phase 4 minocycline
27 Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
28 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
29 Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis Completed NCT03419429 Phase 4 Simvastatin
30 Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization Completed NCT00707369 Phase 4 Amoxicillin and Metronidazole;Placebo
31 Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
32 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Completed NCT00297518 Phase 4
33 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. Completed NCT03642353 Phase 4 Triclosan;Placebo
34 Moxifloxacin in Situ Gel to Treat Periodontal Pocket. Completed NCT02016157 Phase 4 Moxifloxacin
35 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
36 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
37 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
38 Melatonin as an Adjunctive Therapy for Chronic Periodontitis. Completed NCT03368430 Phase 4 Placebo
39 Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease Completed NCT02901743 Phase 4
40 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours Completed NCT02215460 Phase 4 FMS chlorhexidine rinse;FMS placebo rinse;FMS azithromycin tablets;FMS placebo tablets;QS azithromycin tablets;QS placebo tablets;QS chlorhexidine rinse;QS placebo rinse
41 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
42 Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
43 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling Completed NCT03498404 Phase 4
44 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
45 The Effects of Periodontal Therapy on Glycemic Control in Diabetic Patients Completed NCT03783845 Phase 4 amoxicillin and metronidazole
46 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
47 The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis Completed NCT02023840 Phase 4 metronidazole gel;placebo
48 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology Completed NCT02030470 Phase 4
49 EFFECT OF SELECTIVE COX-2 INHIBITOR (ETORICOXIB) ALONG WITH SCALING AND ROOT PLANING (SRP) ON CLINICAL PARAMETERS AND SALIVARY LEVEL OF SUPEROXIDE DISMUTASE IN CHRONIC GENERALIZED PERIODONTITIS A DOUBLE-BLIND, PLACEBO-CONTROLLED, DOUBLE-MASKED RANDOMIZED CONTROLLED TRIAL (RCT). Completed NCT02149758 Phase 4 Etoricoxib
50 MTZ Plus AMX in the Treatment of Smokers and Non-smokers Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: periodontitis

Sources

Genetic Tests for Periodontitis

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Genetic tests related to Periodontitis:

# Genetic test Affiliating Genes
1 Periodontitis 30
Sources

Anatomical Context for Periodontitis

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MalaCards organs/tissues related to Periodontitis:

42
Bone, Neutrophil, Heart, Testes, Endothelial, Kidney, Liver
Sources

Publications for Periodontitis

About this section

Articles related to Periodontitis:

(show top 50) (show all 5939)
# Title Authors Year
1
Six-month clinical outcomes of non-surgical periodontal treatment with antibiotics on apoptosis markers in aggressive periodontitis. ( 30614174 )
2019
2
One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis. ( 30684915 )
2019
3
Protein carbonyl levels in serum, saliva and gingival crevicular fluid in patients with chronic and aggressive periodontitis. ( 30705565 )
2019
4
Comparison of the oral microbiome of patients with generalized aggressive periodontitis and periodontitis-free subjects. ( 30710838 )
2019
5
A Double-Crown Concept for Restorations in Patients with Generalized Aggressive Periodontitis: Two Case Reports with 22- and 25-Year Follow-ups. ( 30794256 )
2019
6
Regeneration of the Periodontal Apparatus in Aggressive Periodontitis Patients. ( 30857253 )
2019
7
Response to "Identification of genetic risk factors of aggressive periodontitis using genome-wide association studies in association with those of chronic periodontitis". ( 30900245 )
2019
8
Management of periodontic-endodontic lesion in aggressive periodontitis-9 months follow-up: Report of a case. ( 30900677 )
2019
9
Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls. ( 30909081 )
2019
10
Comparison of Subgingival and Buccal Mucosa Microbiome in Chronic and Aggressive Periodontitis: A Pilot Study. ( 30915280 )
2019
11
Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. ( 30834192 )
2019
12
Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case-control study. ( 30658685 )
2019
13
Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signalling pathway. ( 30636333 )
2019
14
Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis-A pilot study. ( 30399509 )
2019
15
microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. ( 30125982 )
2019
16
Micro-CT analysis of chronic apical periodontitis induced by several specific pathogens. ( 30734930 )
2019
17
Endothelial Dysfunction Marker Variation in Young Adults with Chronic Apical Periodontitis before and after Endodontic Treatment. ( 30910354 )
2019
18
Association of Chronic Periodontitis on Alzheimer's Disease or Vascular Dementia. ( 30874308 )
2019
19
Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor. ( 30530235 )
2019
20
Probiotics as an Adjunct Therapy for the Treatment of Halitosis, Dental Caries and Periodontitis. ( 30729452 )
2019
21
Is there an association between depression and periodontitis? A birth cohort study. ( 30499588 )
2019
22
Correlation between Diabetes Mellitus and Periodontitis in Taiwan: A Nationwide Cohort Study. ( 30880092 )
2019
23
Proinflammatory (CD14+CD16++) monocytes in type 2 diabetes mellitus patients with/without chronic periodontitis. ( 30820203 )
2019
24
Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus. ( 30755772 )
2019
25
A comparative evaluation of the micronutrient profile in the serum of diabetes mellitus Type II patients and healthy individuals with periodontitis. ( 30692737 )
2019
26
Cyclosporine A - Induced gingival overgrowth and proliferating cell nuclear antigen expression in experimental periodontitis. ( 30386719 )
2019
27
Evidence-Based Update on Diagnosis and Management of Gingivitis and Periodontitis. ( 30447793 )
2019
28
Real time detection and quantification of Epstein Barr virus in different grades of oral gingivitis and periodontitis patients. ( 30658021 )
2019
29
High-fat diet aggravates the liver disease caused by periodontitis in rats. ( 30801719 )
2019
30
Periodontitis as a risk factor for lung cancer among women: A nationwide matched cohort study. ( 30848030 )
2019
31
Association of Periodontitis with Oral Cancer: A Case-Control Study. ( 30779879 )
2019
32
Zoledronate Treatment Duration Is Linked to Bisphosphonate-Related ONJ Prevalence in Rice Rats with Generalized Periodontitis. ( 30712276 )
2019
33
Clinically Relevant Doses of Sclerostin Antibody Do Not Induce Osteonecrosis of the Jaw (ONJ) in Rats with Experimental Periodontitis. ( 30184271 )
2019
34
The potential effect of Bruton's tyrosine kinase in refractory periapical periodontitis. ( 30818138 )
2019
35
Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. ( 30863409 )
2019
36
Bacteremia after professional mechanical plaque removal in patients with chronic periodontitis. ( 30680855 )
2019
37
NLRP12 Attenuates Inflammatory Bone Loss in Experimental Apical Periodontitis. ( 30681895 )
2019
38
Study suggesting an association between periodontitis and periodontal inflammation and mild cognitive impairment in elderly patients has high risk of bias. ( 30683302 )
2019
39
UTILISATION OF ANTIMICROBIAL PHOTODYNAMIC THERAPY AS AN ADJUNCTIVE TOOL FOR OPEN FLAP DEBRIDEMENT IN THE MANAGEMENT OF CHRONIC PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL. ( 30684674 )
2019
40
Nuclear morphological changes in gingival epithelial cells of patients with periodontitis. ( 30685794 )
2019
41
Functional assessment of peptide-modified PLGA nanoparticles against oral biofilms in a murine model of periodontitis. ( 30690103 )
2019
42
Interleukin-21 and its association with chronic periodontitis. ( 30692738 )
2019
43
Evaluation of Long-Term Effects of Diode Laser Application in Periodontal Treatment of Poor Controlled Type-2 Diabetic Patients with Chronic Periodontitis. ( 30697968 )
2019
44
Long-term Association of Periodontitis With Decreased Kidney Function. ( 30704881 )
2019
45
Comparative analysis of prevalence of apical periodontitis in smokers and non-smokers using cone-beam computed tomography. ( 30705569 )
2019
46
Cross Talk between Apical Periodontitis and Metabolic Disorders: Experimental Evidence on the Role of Intestinal Adipokines and Akkermansia muciniphila. ( 30711174 )
2019
47
Chronic periodontitis and reduced respiratory function. ( 30712268 )
2019
48
Topical application of cashew gum or chlorhexidine gel reduces overexpression of proinflammatory genes in experimental periodontitis. ( 30716373 )
2019
49
Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer's disease. ( 30728914 )
2019
50
Effect of maternal periodontitis on GLUT4 and inflammatory pathway in adult offspring. ( 30729535 )
2019
Sources

Variations for Periodontitis

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ClinVar genetic disease variations for Periodontitis:

6 (show all 32)
# Gene Variation Type Significance SNP ID Assembly Location
1 FPR1 NM_002029.3(FPR1): c.993C> T (p.Thr331=) single nucleotide variant Benign rs17849971 GRCh38 Chromosome 19, 51746002: 51746002
2 FPR1 NM_002029.3(FPR1): c.993C> T (p.Thr331=) single nucleotide variant Benign rs17849971 GRCh37 Chromosome 19, 52249255: 52249255
3 FPR1 NM_002029.3(FPR1): c.488G> A (p.Arg163His) single nucleotide variant Benign rs111768566 GRCh38 Chromosome 19, 51746507: 51746507
4 FPR1 NM_002029.3(FPR1): c.488G> A (p.Arg163His) single nucleotide variant Benign rs111768566 GRCh37 Chromosome 19, 52249760: 52249760
5 FPR1 NM_002029.3(FPR1): c.306T> C (p.Phe102=) single nucleotide variant Benign rs28930680 GRCh37 Chromosome 19, 52249942: 52249942
6 FPR1 NM_002029.3(FPR1): c.306T> C (p.Phe102=) single nucleotide variant Benign rs28930680 GRCh38 Chromosome 19, 51746689: 51746689
7 FPR1 NM_002029.3(FPR1): c.26C> T (p.Thr9Met) single nucleotide variant Likely benign rs148095693 GRCh37 Chromosome 19, 52250222: 52250222
8 FPR1 NM_002029.3(FPR1): c.26C> T (p.Thr9Met) single nucleotide variant Likely benign rs148095693 GRCh38 Chromosome 19, 51746969: 51746969
9 FPR1 NM_002029.3(FPR1): c.348C> T (p.Ile116=) single nucleotide variant Benign rs5030879 GRCh37 Chromosome 19, 52249900: 52249900
10 FPR1 NM_002029.3(FPR1): c.348C> T (p.Ile116=) single nucleotide variant Benign rs5030879 GRCh38 Chromosome 19, 51746647: 51746647
11 FPR1 NM_002029.3(FPR1): c.177C> T (p.Val59=) single nucleotide variant Benign rs61736491 GRCh37 Chromosome 19, 52250071: 52250071
12 FPR1 NM_002029.3(FPR1): c.177C> T (p.Val59=) single nucleotide variant Benign rs61736491 GRCh38 Chromosome 19, 51746818: 51746818
13 FPR1 NM_002029.3(FPR1): c.1037_1038delAGinsCA (p.Glu346Ala) indel Benign rs1555796329 GRCh38 Chromosome 19, 51745957: 51745958
14 FPR1 NM_002029.3(FPR1): c.1037_1038delAGinsCA (p.Glu346Ala) indel Benign rs1555796329 GRCh37 Chromosome 19, 52249210: 52249211
15 FPR1 NM_002029.3(FPR1): c.827A> G (p.Tyr276Cys) single nucleotide variant Uncertain significance rs1555796364 GRCh38 Chromosome 19, 51746168: 51746168
16 FPR1 NM_002029.3(FPR1): c.827A> G (p.Tyr276Cys) single nucleotide variant Uncertain significance rs1555796364 GRCh37 Chromosome 19, 52249421: 52249421
17 FPR1 NM_002029.3(FPR1): c.806G> A (p.Arg269His) single nucleotide variant Benign rs142210016 GRCh38 Chromosome 19, 51746189: 51746189
18 FPR1 NM_002029.3(FPR1): c.806G> A (p.Arg269His) single nucleotide variant Benign rs142210016 GRCh37 Chromosome 19, 52249442: 52249442
19 FPR1 NM_002029.3(FPR1): c.674C> T (p.Ala225Val) single nucleotide variant Uncertain significance rs141913828 GRCh38 Chromosome 19, 51746321: 51746321
20 FPR1 NM_002029.3(FPR1): c.674C> T (p.Ala225Val) single nucleotide variant Uncertain significance rs141913828 GRCh37 Chromosome 19, 52249574: 52249574
21 FPR1 NM_002029.3(FPR1): c.289C> A (p.Leu97Met) single nucleotide variant Benign rs78488639 GRCh37 Chromosome 19, 52249959: 52249959
22 FPR1 NM_002029.3(FPR1): c.289C> A (p.Leu97Met) single nucleotide variant Benign rs78488639 GRCh38 Chromosome 19, 51746706: 51746706
23 FPR1 NM_002029.3(FPR1): c.645C> T (p.Ser215=) single nucleotide variant Benign rs35264765 GRCh38 Chromosome 19, 51746350: 51746350
24 FPR1 NM_002029.3(FPR1): c.645C> T (p.Ser215=) single nucleotide variant Benign rs35264765 GRCh37 Chromosome 19, 52249603: 52249603
25 FPR1 NM_002029.3(FPR1): c.117C> T (p.Leu39=) single nucleotide variant Benign rs149382837 GRCh38 Chromosome 19, 51746878: 51746878
26 FPR1 NM_002029.3(FPR1): c.117C> T (p.Leu39=) single nucleotide variant Benign rs149382837 GRCh37 Chromosome 19, 52250131: 52250131
27 FPR1 NM_002029.3(FPR1): c.805C> T (p.Arg269Cys) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 52249443: 52249443
28 FPR1 NM_002029.3(FPR1): c.805C> T (p.Arg269Cys) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 51746190: 51746190
29 FPR1 NM_002029.3(FPR1): c.409C> T (p.Arg137Cys) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 52249839: 52249839
30 FPR1 NM_002029.3(FPR1): c.409C> T (p.Arg137Cys) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 51746586: 51746586
31 FPR1 NM_002029.3(FPR1): c.534T> A (p.Phe178Leu) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 52249714: 52249714
32 FPR1 NM_002029.3(FPR1): c.534T> A (p.Phe178Leu) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 51746461: 51746461
Sources

Expression for Periodontitis

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Search GEO for disease gene expression data for Periodontitis.
Sources

Pathways for Periodontitis

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Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.98 CRP CTSC CXCL8 FPR1 IL10 IL17A
2
PEDF Induced Signaling 65
Show member pathways
 13.79 CXCL8 IL10 IL17A IL1A IL1B IL6
3
TGF-Beta Pathway 65
Show member pathways
 13.6 CXCL8 IL10 IL17A IL1A IL1B IL6
4
Akt Signaling 65
Show member pathways
 13.51 CXCL8 IL10 IL17A IL1A IL1B IL6
5
PAK Pathway 65
Show member pathways
 13.43 CXCL8 IL10 IL17A IL1A IL1B IL6
6
Cytokine Signaling in Immune system 67
Show member pathways
 13.38 CXCL8 FPR1 IL10 IL17A IL1A IL1B
7
Toll-like Receptor Signaling Pathway 38 1
Show member pathways
 13.29 CXCL8 IL10 IL1B IL6 TLR2 TLR4
8
Human cytomegalovirus infection 38
Show member pathways
 13.07 CXCL8 IL1B IL6 MMP9 TLR2 TLR4
9
Allograft rejection 1 38
Show member pathways
 13 CXCL8 IL10 IL17A IL1A IL1B IL6
10
NF-KappaB Family Pathway 65
Show member pathways
 12.85 IL1A IL1B IL6 TIMP1 TLR2 TLR4
11
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.82 CXCL8 IL1B IL6 TLR4 TNF
12
TRAF Pathway 65
Show member pathways
 12.77 IL1A IL1B TLR2 TLR4 TNF TNFRSF11B
13
Th17 cell differentiation 38
Show member pathways
 12.74 IL10 IL17A IL1A IL1B IL6 TLR2
14
Immune response IL-23 signaling pathway 23
Show member pathways
 12.73 IL10 IL17A IL1B IL6 TIMP1 TNF
15
Influenza A 38
Show member pathways
 12.73 CXCL8 IL1A IL1B IL6 TLR2 TLR4
16
NF-kappaB Signaling 4
12.7 IL10 IL17A IL1B TLR2 TNF TNFSF11
17
T cell receptor signaling pathway 38
Show member pathways
 12.58 IL10 IL17A IL1A IL1B IL6 TNF
18
Toll Comparative Pathway 65
Show member pathways
 12.47 CXCL8 IL1A IL1B IL6 TLR4 TNF
19
IL-17 Family Signaling Pathways 66
Show member pathways
 12.46 CXCL8 IL17A IL1B IL6 MMP1 MMP9
20
Diseases associated with the TLR signaling cascade 67
Show member pathways