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MCID: PRD008
MIFTS: 63

Periodontitis

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Periodontitis

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MalaCards integrated aliases for Periodontitis:

Name: Periodontitis 12 73 29 6 44 15 17 70
Chronic Pericementitis 12
Chronic Periodontitis 70

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:824
MeSH 44 D010518
NCIt 50 C34918
SNOMED-CT 67 266491004
ICD10 32 K05.3
UMLS 70 C0031099 C0266929
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Summaries for Periodontitis

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MalaCards based summary : Periodontitis, also known as chronic pericementitis, is related to periodontitis, chronic and periodontitis, aggressive, 1, and has symptoms including leukorrhea and purulent discharge. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ethanol and Risedronate have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 73 Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the... more...

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Related Diseases for Periodontitis

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Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1112)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 33.3 TNFSF11 MMP8 MMP1 IL6 IL1B
2 periodontitis, aggressive, 1 33.2 MMP8 MMP1 IL1A FPR1 CTSC
3 suppurative periapical periodontitis 32.6 IL6 IL1B CXCL8 CRP
4 chronic apical periodontitis 32.5 TNFSF11 MIR146A IL1B
5 acute pericementitis 32.4 IL1B CXCL8
6 periapical periodontitis 32.2 TNFSF11 TNF TLR2 MMP9 MMP8 IL6
7 aggressive periodontitis 32.2 TNFSF11 TNF TLR4 TLR2 PDON2 MMP9
8 bone resorption disease 31.8 TNFSF11 TNF IL6 IL1B CTSK CRP
9 gingivitis 31.6 TNF TLR2 MMP9 MMP8 MMP1 IL6
10 gingival recession 31.5 TNFSF11 TNF MMP8 IL6 IL1B CRP
11 dental pulp necrosis 31.3 TNFSF11 TNF IL1B
12 pulpitis 31.2 TNF MMP1 IL6 IL1B IL1A CXCL8
13 gingival overgrowth 31.2 TNF MMP8 MMP1 IL6 IL1A CXCL8
14 atherosclerosis susceptibility 31.1 TNF TLR4 MMP9 IL6 IL1B CXCL8
15 root resorption 31.0 TNFSF11 MMP9 IL6 IL1B IL1A CTSK
16 gingival disease 31.0 TNFSF11 TNF TLR4 TLR2 SIGLEC5 MMP9
17 osteonecrosis 30.9 TNFSF11 TNF IL1B
18 fatty liver disease 30.9 TNF IL6 IL1B IL1A CXCL8
19 stomatitis 30.9 TNF IL6 IL1B IL10 CXCL8
20 periapical granuloma 30.9 TNFSF11 TLR2 MMP8 CXCL8
21 arteries, anomalies of 30.9 TNF MIR146A IL6 IL1B CRP
22 end stage renal disease 30.9 TNF IL6 IL1B IL10 CRP
23 chronic kidney disease 30.9 TNFSF11 TNF TLR4 MMP9 IL6 IL1B
24 type 1 diabetes mellitus 30.8 TNF TLR4 IL6 IL1B IL10 CXCL8
25 gastritis 30.8 TNF TLR4 IL6 IL1B IL10 CXCL8
26 infective endocarditis 30.8 TNF TLR2 IL6 CRP
27 pre-eclampsia 30.8 TNF TLR4 MMP9 IL6 IL1B IL10
28 neutropenia 30.7 TNF IL6 IL1B IL10 CXCL8 CRP
29 helicobacter pylori infection 30.7 TNF IL1B IL10 CXCL8
30 bacterial infectious disease 30.7 TNF TLR4 TLR2 IL6 IL1B IL1A
31 lichen planus 30.7 TNF IL6 IL1B IL10 CXCL8
32 cyclic neutropenia 30.7 TNF IL1B CXCL8
33 non-alcoholic fatty liver disease 30.7 TNF TLR4 IL6 IL1B IL1A IL10
34 pustulosis of palm and sole 30.7 TNF SIGLEC5 CXCL8 CRP
35 liver disease 30.7 TNF IL6 IL1B IL1A CXCL8
36 proteasome-associated autoinflammatory syndrome 1 30.7 TNF TLR4 TLR2 MMP9 IL6 IL1B
37 ulcerative colitis 30.7 TNF TLR4 IL6 IL1B IL10 CXCL8
38 endocarditis 30.7 TNF TLR2 IL6 IL1A IL10 CXCL8
39 haemophilus influenzae 30.7 TNF TLR2 CXCL8
40 allergic disease 30.6 TNF TLR4 TLR2 IL6 IL1B IL10
41 sleep apnea 30.6 TNF IL6 IL1B IL10 CXCL8 CRP
42 type 2 diabetes mellitus 30.6 TNFSF11 TNF TLR4 MMP9 MMP8 MMP1
43 stroke, ischemic 30.6 TNF TLR4 MMP9 IL6 IL1B CRP
44 cerebrovascular disease 30.6 TNF TLR4 MMP9 IL6 CRP
45 juvenile rheumatoid arthritis 30.6 TNF IL6 IL1B IL10 CXCL8 CRP
46 peripheral artery disease 30.6 TNF IL6 CRP CDKN2B-AS1
47 actinomycosis 30.6 TNF IL6 IL1B IL10 CRP
48 migraine with or without aura 1 30.6 TNF IL6 IL1B IL10 CRP
49 vascular disease 30.6 TNF TLR4 MMP9 MIR146A IL6 IL1A
50 peptic ulcer disease 30.6 TNF IL1B IL10 CXCL8

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to Periodontitis
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Symptoms & Phenotypes for Periodontitis

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UMLS symptoms related to Periodontitis:


leukorrhea; purulent discharge

MGI Mouse Phenotypes related to Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 CRP CTSC CTSK FPR1 IL10 IL1A
2 hematopoietic system MP:0005397 10.15 CTSC CTSK FPR1 IL10 IL1A IL1B
3 immune system MP:0005387 10.13 CRP CTSC CTSK FPR1 IL10 IL1A
4 integument MP:0010771 9.85 CTSC IL10 IL1A IL1B IL6 MMP9
5 neoplasm MP:0002006 9.7 IL10 IL1A IL1B IL6 MMP1 MMP8
6 respiratory system MP:0005388 9.23 CTSK IL10 IL6 MMP9 TLR2 TLR4
Sources

Drugs & Therapeutics for Periodontitis

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Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 384)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
3
Cetylpyridinium Approved Phase 4 7773-52-6
4
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
5
Menthol Approved Phase 4 2216-51-5 16666
6
Lactitol Approved, Investigational Phase 4 585-86-4 157355
7
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
8
Licorice Approved Phase 4
9
Zoledronic Acid Approved Phase 4 118072-93-8 68740
10
Coal tar Approved Phase 4 8007-45-2
11
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
12
Lovastatin Approved, Investigational Phase 4 75330-75-5 53232
13
Simvastatin Approved Phase 4 79902-63-9 54454
14
Turmeric Approved, Experimental, Investigational Phase 4
15
Atorvastatin Approved Phase 4 134523-00-5 60823
16
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
17
Racepinephrine Approved Phase 4 329-65-7 838
18
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
19
Polyestradiol phosphate Approved Phase 4 28014-46-2
20
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
21
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
22
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
23
sodium fluoride Approved Phase 4 7681-49-4
24
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
25
Montelukast Approved Phase 4 158966-92-8 5281040
26
Clarithromycin Approved Phase 4 81103-11-9 84029
27
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
28
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
29
Ofloxacin Approved Phase 4 82419-36-1 4583
30
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
31
Prilocaine Approved Phase 4 721-50-6 4906
32
Hexetidine Approved, Investigational Phase 4 141-94-6
33
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
34
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
35
Sodium citrate Approved, Investigational Phase 4 68-04-2
36
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
37
Potassium citrate Approved, Investigational, Vet_approved Phase 4 866-84-2
38
Zinc oxide Approved Phase 4 1314-13-2
39
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
40
Eugenol Approved Phase 4 97-53-0 3314
41
Metronidazole Approved Phase 4 443-48-1 4173
42
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
43
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
44
Azithromycin Approved Phase 4 83905-01-5 55185 447043
45
Edetic Acid Approved, Vet_approved Phase 4 60-00-4, 62-33-9 6049
46
Pentetic acid Approved Phase 4 67-43-6
47
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
48
Ibuprofen Approved Phase 4 15687-27-1 3672
49
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
50
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311

Interventional clinical trials:

(show top 50) (show all 1282)
# Name Status NCT ID Phase Drugs
1 Effect of Probiotic Lactobacillus Reuteri-containing Lozenges (Prodentis) on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
2 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
3 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
4 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
5 Preparation and Analysis of Material, Biological and Clinical Parameters of Metronidazole-loaded Porous Matrices for Local Periodontitis Treatment Unknown status NCT03791099 Phase 4 Metronidazole
6 Filling of Periodontal Pockets With a Commercially Available Injectable Cross-linked Hyaluronic Acid Dental Filler Versus Oral Hygiene Alone, After Scaling and Root Planing and Chlorhexidine Disinfection, for the Treatment of Periodontitis: A Single-blinded, Multi Center, Prospective, Randomized Controlled Trial Unknown status NCT02391974 Phase 4
7 Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection: Randomized Clinical Trial. Unknown status NCT03863249 Phase 4 ADJUNTIVE ANTIBIOTICS
8 Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone Unknown status NCT00296881 Phase 4
9 Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis Unknown status NCT00297531 Phase 4
10 Evaluating the Adjunctive Effect of Stress Reduction Protocol in the Non-Surgical Periodontal Therapy of Chronic Periodontitis Subjects Associated With Stress: A Randomized Control Pilot Study Unknown status NCT02487862 Phase 4
11 The Efficacy of Cyanoacrylate (PeriAcryl®90 HV) in Its Adhesive Post-Operative Properties on Periodontal Wound Healing and Patient Discomfort After Non-Surgical Periodontal Treatment: A Pilot Randomized Clinical Trial Unknown status NCT02826109 Phase 4
12 Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial Unknown status NCT02135952 Phase 4 MTZ+AMX
13 A Clinical and Radiographic Evaluation of DFDBA (Demineralised Freeze Dried Bone Allograft) With Amniotic Membrane (AM) in the Treatment of Periodontal Osseous Defects-12 Month Randomized Controlled Clinical Trial Unknown status NCT02635529 Phase 4
14 Phase IV Study to Evaluate and Compare the Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Rinse With Regards to Managing Post-surgical Inflammation Associated With Dental Implant Surgery Unknown status NCT02987634 Phase 4
15 Methodology of Application and Immediate Effect of the Essential Oils and 0.2% Chlorhexidine on Oral Biofilm: Immersion Versus Mouthwash. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
16 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. A Randomized Clinical Trial Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
17 Essential Oils With and Without Alcohol: in Vivo Antibacterial Effect Unknown status NCT03146390 Phase 4 Essential oils;Alcohol free essential oils
18 Evaluation of Platelet Rich Fibrin Efficacy on Reduction of Periodontal Problems Unknown status NCT01583491 Phase 4
19 The Treatment of Periodontal Diseases. A Randomized, Blinded, Five Years Follow-up, Four-arm, Placebo Controlled Clinical Intervention Trial Unknown status NCT01318928 Phase 4 Metronidazol
20 Mouthwashes as Positive Modulators of Periodontal Response During Orthodontic Treatment: a 6-month Randomized Placebo Controlled Clinical Trial Unknown status NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
21 Efficacy of Complex Phytoadaptogenes as an Adjunct to Non-surgical Periodontal Treatment in Patients With Chronic Periodontitis: a Randomized Clinical Trial Completed NCT04623164 Phase 4 Cocktail from complex phytoadaptogens (CFA)
22 Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study Completed NCT02808988 Phase 4
23 Efficacy of Adjunctive Photodynamic Therapy in Non-surgical Treatment of Chronic Periodontitis: a Randomized , Controlled Clinical Trial Completed NCT01034501 Phase 4
24 Effects of Application Injectable Platelet-Rich Fibrin (i-PRF) as Adjunct Therapy in the Initial Treatment of Periodontitis Completed NCT04178590 Phase 4 SRP + Injectable Platelet-Rich Fibrin;SRP + placebo
25 Effects of Ultrasonic Debridement With PVP-iodine Irrigation on Post-treatment Bacteraemia Compared to Ultrasonic Debridement With Water Completed NCT01647347 Phase 4 Supra- and subgingival rinsing with 10% PVP-iodine
26 Influence of Pre-procedural Oral Rinse in the Induced Bacteremia by Periodontal Instrumentation: a Randomized Clinical Trial Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
27 The Local Application of Curcumin in Conjunction With the Surgical Treatment of Intrabony Periodontal Defects "Controlled Clinical Study With Evaluation of Curcumin Release Profile" Completed NCT04032132 Phase 4 curcumin paste
28 Curcumin-Simvastatin Release Profile in the Gingival Crevicular Fluid Following EDTA Root Surface Etching in the Surgical Treatment of Intrabony Periodontal Defects - A Biochemical and Clinical Study Completed NCT04044417 Phase 4 curcumin simvastatin paste;EDTA root conditioning
29 The Use of Erythritol Powder and Locally Derived Metronidazole for the Non-surgical Treatment of Periodontitis: a Split-mouth Randomized Controlled Clinical Trial Completed NCT02023840 Phase 4 metronidazole gel;placebo
30 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
31 "Comparative Evaluation Of The Efficacy Of Atorvastatin Gel As An Adjunct To Allografts In The Treatment Of Intrabony Defects" - A Clinico Radiological Study Completed NCT03009097 Phase 4 DFDBA with atorvastatin
32 Effect of Scaling & Root Planing (SRP) Combined With Therapy Of Omega-3 Fatty Acid on Clinical Parameters and Serum Levels of C-Reactive Protein (CRP) in Chronic Periodontitis - A Randomised Control Trial. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
33 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling in Patients With Advanced Chronic Periodontitis Completed NCT03498404 Phase 4
34 Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase Completed NCT04675385 Phase 4 0.2% hyaluronic acid gel
35 The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial) Completed NCT03783845 Phase 4
36 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis: Randomized Clinical Trial Completed NCT03025204 Phase 4
37 Clinical and Microbiological of Antimicrobial Photodynamic Therapy on Surgical Treatment of Chronic Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial. Completed NCT02734784 Phase 4
38 Systemic Lycopene as an Adjunct to Scaling and Rootplaning in Chronic Periodontitis Patients With Type 2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
39 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)
40 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole as Adjunctive Therapy to Mechanical Treatment of Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
41 The Use of Simvastatin Gel With Perforated Resorbable Membranes in the Treatment of Intrabony Defects in Chronic Periodontitis Patients (Clinical and Biochemical Study) Completed NCT03419429 Phase 4 Simvastatin
42 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin: a Clinical Trial Completed NCT02641210 Phase 4 Albendazole
43 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
44 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
45 The Response of Periodontal Pathogens to the Respective or Combined Treatment of Scaling and Root Planning and Locally Delivered Minocycline in Patients With Chronic Periodontitis- a Short-term Randomized Clinical Trial Completed NCT02355977 Phase 4 minocycline
46 The Effect Of SRP With Adjunctive Systemic Therapy Of Leukotriene Receptor Antagonist-Montelukast On The Serum C Reactive Protein Levels & Clinical Parameters In Chronic Periodontitis Patients - A Randomized Controlled Trial Completed NCT02014532 Phase 4 Montelukast;Placebo
47 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
48 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
49 EFFECT OF SRP WITH ADJUNCTIVE THERAPY OF HERBAL IMMUNOMODULATORS ON THE SERUM C REACTIVE PROTEIN (CRP) LEVELS & CLINICAL PARAMETERS IN CHRONIC PERIODONTITIS PATIENTS - A RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED, CLINICAL TRIAL. Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
50 Clinical and Microbiological Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers. Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


carbamide peroxide

Cochrane evidence based reviews: periodontitis

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Genetic Tests for Periodontitis

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Genetic tests related to Periodontitis:

# Genetic test Affiliating Genes
1 Periodontitis 29
Sources

Anatomical Context for Periodontitis

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MalaCards organs/tissues related to Periodontitis:

40
Bone, Neutrophil, Endothelial, T Cells, Tongue, Monocytes, Heart
Sources

Publications for Periodontitis

About this section

Articles related to Periodontitis:

(show top 50) (show all 27499)
# Title Authors PMID Year
1
Electrosprayed minocycline hydrochloride-loaded microsphere/SAIB hybrid depot for periodontitis treatment. 61
33779441 2021
2
Prevalence of oral conditions among methamphetamine users: NHANES 2009-2014. 61
32812220 2021
3
Etiology of aggressive periodontitis in individuals of African descent. 61
33737991 2021
4
Impact of Green Tea (Camellia Sinensis) on periodontitis and caries. Systematic review and meta-analysis. 61
33737989 2021
5
The protective effect of tetrahedral framework nucleic acids on periodontium under inflammatory conditions. 61
33313447 2021
6
Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review). 61
33728046 2021
7
Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review). 61
33760138 2021
8
The role of adiponectin in periodontitis: Current state and future prospects. 61
33561644 2021
9
Risk factors for bisphosphonate-associated osteonecrosis of the jaw in the prospective randomized trial of adjuvant bisphosphonates for early-stage breast cancer (SWOG 0307). 61
32929540 2021
10
Hyperresponsiveness of human gingival fibroblasts from patients with aggressive periodontitis against bacterial lipopolysaccharide. 61
33747158 2021
11
Soluble neuropilin-1 in gingival crevicular fluid is associated with rheumatoid arthritis: An exploratory case-control study. 61
33747759 2021
12
Adipokines and periodontal markers as risk indicators of early rheumatoid arthritis: a cross-sectional study. 61
32740810 2021
13
Clinical and microbiological effects of non-surgical periodontal treatment in individuals with rheumatoid arthritis: a controlled clinical trial. 61
33145632 2021
14
[Periodontal rehabilitation in a deaf patient with symptomatic epilepsy in Sturge-Weber syndrome - a case report]. 61
33789417 2021
15
Periodontal inflammation triggers a site-specific and wide radius of calcium metabolic effects on alveolar bone. 61
33314132 2021
16
Knockout of NRAGE promotes autophagy-related gene expression and the periodontitis process in mice. 61
32750749 2021
17
Effects of the Association of Periodontitis and Type 1 Diabetes Mellitus Induced on Periodontal Tissues and the Duodenal Mucosa of Wistar Rats. 61
33174137 2021
18
Adjunctive systemic antimicrobials in the treatment of chronic periodontitis: A systematic review and network meta-analysis. 61
33314159 2021
19
Two patients with Papillon-Lefèvre syndrome without periodontal involvement of the permanent dentition. 61
33580910 2021
20
Effects of smoking on the gingival crevicular fluid levels of interleukin-17A, interleukin-17E, and oxidative stress following periodontal treatment process. 61
33458831 2021
21
Periodontal status in children with primary immunodeficiencies. 61
33811759 2021
22
Porphyromonas gingivalis facilitated the foam cell formation via lysosomal integral membrane protein 2 (LIMP2). 61
33372271 2021
23
1α,25-dihydroxyvitamin D3 promotes early osteogenic differentiation of PDLSCs and a 12-year follow-up case of early-onset vitamin D deficiency periodontitis. 61
33486080 2021
24
Effect of endodontic treatment on periodontal healing of grade 3 endo-periodontal lesions without root damage in periodontally compromised patients-a retrospective pilot study. 61
32948927 2021
25
Periodontal Pathogens' strategies disarm neutrophils to promote dysregulated inflammation. 61
33128827 2021
26
Molecular Strategies Underlying Porphyromonas gingivalis Virulence. 61
33539891 2021
27
Systemic inflammatory response to non-surgical treatment in hypertensive patients with periodontal infection. 61
33787581 2021
28
Evaluation of Temperature Increase From Joule Heat in Numerical Tooth Model by Applying 500 kHz Current for Apical Periodontitis Treatment-Effect of Applied Voltage and Tooth Conductivity. 61
33537989 2021
29
Is systemic inflammation a missing link between periodontitis and hypertension? Results from two large population-based surveys. 61
32969093 2021
30
Influence of a High-fat Diet in the Progression of Apical Periodontitis. 61
33387552 2021
31
Evaluation of the effect of periodontitis on quality of life using Oral-Dental Health-Related Quality of Life-United Kingdom scale. 61
33797852 2021
32
Direct MALDI-TOF profiling of gingival crevicular fluid sediments for periodontitis diagnosis. 61
33592711 2021
33
Impact of root canal treatment on high-sensitivity C-reactive protein levels in systemically healthy adults with apical periodontitis - a preliminary prospective, longitudinal interventional study. 61
33185278 2021
34
The effect of treated apical periodontitis before heart valve surgery on C-reactive protein levels. 61
32710519 2021
35
Microbiological analysis of endodontically treated teeth with apical periodontitis before and after endodontic retreatment. 61
32860137 2021
36
Finding distinctions between oral cancer and periodontitis using saliva metabolites and machine learning. 61
32762095 2021
37
Effect of adjuvant bisphosphonates on treatment of periodontitis: Systematic review with meta-analyses. 61
33537188 2021
38
Renal alterations caused by ligature-induced periodontitis persist after ligature removal in rats. 61
33296521 2021
39
Expression profile of lipoxygenases in gingival tissues of human periodontitis. 61
32677134 2021
40
Mechanisms involved in regulation of periodontal ligament cell production of pro-inflammatory cytokines: Implications in periodontitis. 61
33305420 2021
41
Oral microbiome interactions with gingival gene expression patterns for apoptosis, autophagy and hypoxia pathways in progressing periodontitis. 61
33314069 2021
42
Circ_0081572 inhibits the progression of periodontitis through regulating the miR-378h/RORA axis. 61
33524877 2021
43
Long non-coding RNA TUG1 participates in LPS-induced periodontitis by regulating miR-498/RORA pathway. 61
32762066 2021
44
Cellular composition and cytomorphological characteristics of periodontal pockets of patients with periodontitis using Leishman-Giemsa cocktail staining. 61
32986287 2021
45
Competing interplay between systemic and periodontal inflammation: obesity overrides the impact of oral periphery. 61
32827080 2021
46
The impact of maternal periodontitis in the development of asthma in the offspring. 61
32314681 2021
47
Anti-inflammatory effect of glycyrrhizin with Equisetum arvense extract. 61
33141307 2021
48
Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice. 61
33512709 2021
49
Influence of photodynamic therapy on the periodontitis-induced bone resorption in rat. 61
32808146 2021
50
Relationship between periodontal disease and male infertility: A case-control study. 61
32702140 2021
Sources

Variations for Periodontitis

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ClinVar genetic disease variations for Periodontitis:

6 (show top 50) (show all 63)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CTSK NM_000396.4(CTSK):c.905G>A (p.Trp302Ter) SNV Uncertain significance 684727 rs1571122183 GRCh37: 1:150769360-150769360
GRCh38: 1:150796884-150796884
2 FPR1 NC_000019.10:g.(?_51745922)_(51759909_?)dup Duplication Uncertain significance 831452 GRCh37: 19:52249175-52263162
GRCh38:
3 FPR1 NM_002029.4(FPR1):c.898C>G (p.Leu300Val) SNV Uncertain significance 835264 GRCh37: 19:52249350-52249350
GRCh38: 19:51746097-51746097
4 FPR1 NM_002029.4(FPR1):c.736G>T (p.Val246Phe) SNV Uncertain significance 836559 GRCh37: 19:52249512-52249512
GRCh38: 19:51746259-51746259
5 FPR1 NM_002029.4(FPR1):c.40G>A (p.Gly14Arg) SNV Uncertain significance 838179 GRCh37: 19:52250208-52250208
GRCh38: 19:51746955-51746955
6 FPR1 NM_002029.4(FPR1):c.952G>A (p.Ala318Thr) SNV Uncertain significance 840695 GRCh37: 19:52249296-52249296
GRCh38: 19:51746043-51746043
7 FPR1 NM_002029.4(FPR1):c.440T>C (p.Ile147Thr) SNV Uncertain significance 841167 GRCh37: 19:52249808-52249808
GRCh38: 19:51746555-51746555
8 FPR1 NM_002029.4(FPR1):c.79A>G (p.Ile27Val) SNV Uncertain significance 841693 GRCh37: 19:52250169-52250169
GRCh38: 19:51746916-51746916
9 FPR1 NM_002029.4(FPR1):c.713G>A (p.Arg238His) SNV Uncertain significance 844349 GRCh37: 19:52249535-52249535
GRCh38: 19:51746282-51746282
10 FPR1 NM_002029.4(FPR1):c.955A>C (p.Ser319Arg) SNV Uncertain significance 847520 GRCh37: 19:52249293-52249293
GRCh38: 19:51746040-51746040
11 FPR1 NM_002029.4(FPR1):c.934C>T (p.Leu312=) SNV Uncertain significance 848388 GRCh37: 19:52249314-52249314
GRCh38: 19:51746061-51746061
12 FPR1 NM_002029.4(FPR1):c.613C>T (p.Arg205Trp) SNV Uncertain significance 851750 GRCh37: 19:52249635-52249635
GRCh38: 19:51746382-51746382
13 FPR1 NM_002029.4(FPR1):c.826T>C (p.Tyr276His) SNV Uncertain significance 852538 GRCh37: 19:52249422-52249422
GRCh38: 19:51746169-51746169
14 FPR1 NM_002029.4(FPR1):c.570G>C (p.Arg190Ser) SNV Uncertain significance 856172 GRCh37: 19:52249678-52249678
GRCh38: 19:51746425-51746425
15 FPR1 NM_002029.4(FPR1):c.331G>A (p.Gly111Arg) SNV Uncertain significance 860414 GRCh37: 19:52249917-52249917
GRCh38: 19:51746664-51746664
16 FPR1 NM_002029.4(FPR1):c.654T>A (p.Ala218=) SNV Uncertain significance 937938 GRCh37: 19:52249594-52249594
GRCh38: 19:51746341-51746341
17 FPR1 NM_002029.4(FPR1):c.721C>T (p.Arg241Trp) SNV Uncertain significance 938975 GRCh37: 19:52249527-52249527
GRCh38: 19:51746274-51746274
18 FPR1 NM_002029.4(FPR1):c.596C>T (p.Thr199Met) SNV Uncertain significance 946253 GRCh37: 19:52249652-52249652
GRCh38: 19:51746399-51746399
19 FPR1 NM_002029.4(FPR1):c.722G>A (p.Arg241Gln) SNV Uncertain significance 950010 GRCh37: 19:52249526-52249526
GRCh38: 19:51746273-51746273
20 FPR1 NM_002029.4(FPR1):c.664G>A (p.Gly222Arg) SNV Uncertain significance 951604 GRCh37: 19:52249584-52249584
GRCh38: 19:51746331-51746331
21 FPR1 NM_002029.4(FPR1):c.823A>G (p.Met275Val) SNV Uncertain significance 952169 GRCh37: 19:52249425-52249425
GRCh38: 19:51746172-51746172
22 FPR1 NM_002029.4(FPR1):c.751T>C (p.Phe251Leu) SNV Uncertain significance 956161 GRCh37: 19:52249497-52249497
GRCh38: 19:51746244-51746244
23 FPR1 NM_002029.4(FPR1):c.943G>A (p.Ala315Thr) SNV Uncertain significance 958537 GRCh37: 19:52249305-52249305
GRCh38: 19:51746052-51746052
24 FPR1 NM_002029.4(FPR1):c.919G>A (p.Asp307Asn) SNV Uncertain significance 960581 GRCh37: 19:52249329-52249329
GRCh38: 19:51746076-51746076
25 FPR1 NM_002029.4(FPR1):c.634G>A (p.Ala212Thr) SNV Uncertain significance 963210 GRCh37: 19:52249614-52249614
GRCh38: 19:51746361-51746361
26 FPR1 NM_002029.4(FPR1):c.160C>T (p.Arg54Trp) SNV Uncertain significance 965936 GRCh37: 19:52250088-52250088
GRCh38: 19:51746835-51746835
27 FPR1 NM_002029.4(FPR1):c.497C>T (p.Thr166Ile) SNV Uncertain significance 966326 GRCh37: 19:52249751-52249751
GRCh38: 19:51746498-51746498
28 FPR1 NM_002029.4(FPR1):c.976G>A (p.Glu326Lys) SNV Uncertain significance 1009944 GRCh37: 19:52249272-52249272
GRCh38: 19:51746019-51746019
29 FPR1 NM_002029.4(FPR1):c.80T>A (p.Ile27Asn) SNV Uncertain significance 1021976 GRCh37: 19:52250168-52250168
GRCh38: 19:51746915-51746915
30 FPR1 NM_002029.4(FPR1):c.121G>A (p.Val41Ile) SNV Uncertain significance 1025583 GRCh37: 19:52250127-52250127
GRCh38: 19:51746874-51746874
31 FPR1 NM_002029.4(FPR1):c.824T>C (p.Met275Thr) SNV Uncertain significance 1026436 GRCh37: 19:52249424-52249424
GRCh38: 19:51746171-51746171
32 FPR1 NM_002029.4(FPR1):c.926G>A (p.Arg309Gln) SNV Uncertain significance 1036271 GRCh37: 19:52249322-52249322
GRCh38: 19:51746069-51746069
33 FPR1 NM_002029.4(FPR1):c.407A>C (p.His136Pro) SNV Uncertain significance 1056255 GRCh37: 19:52249841-52249841
GRCh38: 19:51746588-51746588
34 FPR1 NM_002029.3(FPR1):c.827A>G (p.Tyr276Cys) SNV Uncertain significance 526508 rs1555796364 GRCh37: 19:52249421-52249421
GRCh38: 19:51746168-51746168
35 FPR1 NM_002029.3(FPR1):c.674C>T (p.Ala225Val) SNV Uncertain significance 526509 rs141913828 GRCh37: 19:52249574-52249574
GRCh38: 19:51746321-51746321
36 FPR1 NM_002029.3(FPR1):c.534T>A (p.Phe178Leu) SNV Uncertain significance 566652 rs747450344 GRCh37: 19:52249714-52249714
GRCh38: 19:51746461-51746461
37 FPR1 NM_002029.3(FPR1):c.409C>T (p.Arg137Cys) SNV Uncertain significance 575041 rs139132326 GRCh37: 19:52249839-52249839
GRCh38: 19:51746586-51746586
38 FPR1 NM_002029.3(FPR1):c.805C>T (p.Arg269Cys) SNV Uncertain significance 575332 rs771446051 GRCh37: 19:52249443-52249443
GRCh38: 19:51746190-51746190
39 FPR1 NM_002029.3(FPR1):c.559C>T (p.Pro187Ser) SNV Uncertain significance 640589 rs139760904 GRCh37: 19:52249689-52249689
GRCh38: 19:51746436-51746436
40 FPR1 NM_002029.3(FPR1):c.710G>A (p.Ser237Asn) SNV Uncertain significance 641997 rs1302309228 GRCh37: 19:52249538-52249538
GRCh38: 19:51746285-51746285
41 FPR1 NM_002029.3(FPR1):c.511A>C (p.Thr171Pro) SNV Uncertain significance 646664 rs771064181 GRCh37: 19:52249737-52249737
GRCh38: 19:51746484-51746484
42 FPR1 NM_002029.3(FPR1):c.439A>G (p.Ile147Val) SNV Uncertain significance 651669 rs183314714 GRCh37: 19:52249809-52249809
GRCh38: 19:51746556-51746556
43 FPR1 NM_002029.3(FPR1):c.379G>A (p.Val127Ile) SNV Uncertain significance 652351 rs186613919 GRCh37: 19:52249869-52249869
GRCh38: 19:51746616-51746616
44 FPR1 NM_002029.3(FPR1):c.274C>A (p.Pro92Thr) SNV Uncertain significance 656419 rs750324912 GRCh37: 19:52249974-52249974
GRCh38: 19:51746721-51746721
45 FPR1 NM_002029.3(FPR1):c.205G>A (p.Val69Met) SNV Uncertain significance 660114 rs199534146 GRCh37: 19:52250043-52250043
GRCh38: 19:51746790-51746790
46 FPR1 NM_002029.3(FPR1):c.198C>A (p.Asn66Lys) SNV Uncertain significance 660315 rs371282377 GRCh37: 19:52250050-52250050
GRCh38: 19:51746797-51746797
47 FPR1 NM_002029.3(FPR1):c.542C>T (p.Ser181Leu) SNV Uncertain significance 660454 rs146075164 GRCh37: 19:52249706-52249706
GRCh38: 19:51746453-51746453
48 FPR1 NM_002029.3(FPR1):c.744A>C (p.Ala248=) SNV Likely benign 716687 rs145578657 GRCh37: 19:52249504-52249504
GRCh38: 19:51746251-51746251
49 FPR1 NM_002029.3(FPR1):c.582C>T (p.Ala194=) SNV Likely benign 726546 rs747540806 GRCh37: 19:52249666-52249666
GRCh38: 19:51746413-51746413
50 FPR1 NM_002029.3(FPR1):c.607A>G (p.Ile203Val) SNV Likely benign 783851 rs150239733 GRCh37: 19:52249641-52249641
GRCh38: 19:51746388-51746388
Sources

Expression for Periodontitis

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Search GEO for disease gene expression data for Periodontitis.
Sources

Pathways for Periodontitis

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Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.02 TNFSF11 TNF TLR4 TLR2 SIGLEC5 MMP9
2
Akt Signaling 63
Show member pathways
 13.5 TNFSF11 TNF TLR4 TLR2 IL6 IL1B
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.46 TNFSF11 TNF MMP9 MMP1 IL6 IL1B
4
PAK Pathway 63
Show member pathways
 13.35 TNFSF11 TNF IL6 IL1B IL1A IL10
5
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.26 TNF TLR4 TLR2 MMP9 MMP1 IL6
6
Human cytomegalovirus infection 36
Show member pathways
 13 TNF TLR4 TLR2 IL6 IL1B CXCL8
7
Allograft rejection 36 1
Show member pathways
 12.93 TNF IL6 IL1B IL1A IL10 CXCL8
8
Measles 36
Show member pathways
 12.93 TNF TLR4 TLR2 IL6 IL1B IL1A
9
Salmonella infection (KEGG) 36
Show member pathways
 12.83 TNF TLR4 TLR2 IL6 IL1B CXCL8
10
NF-KappaB Family Pathway 63
Show member pathways
 12.8 TNF TLR4 TLR2 IL6 IL1B IL1A
11
RANK Signaling in Osteoclasts 63
Show member pathways
 12.75 TNFSF11 TNF IL1B IL1A IL10 CTSK
12
T cell receptor signaling pathway 36
Show member pathways
 12.72 TNF TLR4 TLR2 IL6 IL1B IL1A
13
Th17 cell differentiation 36
Show member pathways
 12.71 TNF TLR4 TLR2 IL6 IL1B IL1A
14
TRAF Pathway 63
Show member pathways
 12.69 TNFSF11 TNF TLR4 TLR2 IL1B IL1A
15
NF-kappaB Signaling 4
12.64 TNFSF11 TNF TLR2 IL1B IL10
16
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.55 TNF TLR4 TLR2 IL6 IL1B CXCL8
17
Toll Comparative Pathway 63
Show member pathways
 12.45 TNF TLR4 IL6 IL1B IL1A CXCL8
18
Shigellosis 36
12.44 TNF TLR4 IL1B CXCL8
19
IL-17 Family Signaling Pathways 64
Show member pathways
 12.43 TNF TLR2 MMP9 MMP1 IL6 IL1B
20
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.4 TNF TLR4 TLR2 IL6 IL1A CXCL8
21
Toxoplasmosis 36
Show member pathways
 12.39 TNF TLR4 TLR2