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MCID: PRD008
MIFTS: 66

Periodontitis

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Periodontitis

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MalaCards integrated aliases for Periodontitis:

Name: Periodontitis 12 77 30 6 45 15 17 74
Chronic Pericementitis 12
Chronic Periodontitis 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:824
MeSH 45 D010518
NCIt 51 C34918
SNOMED-CT 69 41565005
ICD10 34 K05.3
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Summaries for Periodontitis

About this section
MalaCards based summary : Periodontitis, also known as chronic pericementitis, is related to periodontitis, chronic and periapical periodontitis, and has symptoms including leukorrhea and purulent discharge. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs sodium fluoride and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the... more...

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Related Diseases for Periodontitis

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Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 810)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 34.1 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
2 periapical periodontitis 34.0 IL1B IL6 MMP8 TLR2 TNF TNFRSF11B
3 aggressive periodontitis 33.5 CTSC CXCL8 FPR1 IL10 IL1A IL1B
4 periodontosis 33.3 CXCL8 MMP9 TLR4 TNF TNFSF11
5 periodontal disease 32.5 CRP CTSC CXCL8 IL17A IL1A IL1B
6 gingivitis 32.3 CXCL8 IL1A IL1B IL6 MMP8 MMP9
7 diabetes mellitus 31.5 CDKN2B-AS1 CRP IL1A IL1B IL6 TNF
8 gingival overgrowth 31.5 IL1A IL6 MMP1
9 bone resorption disease 31.1 CTSK IL6 TNFRSF11B TNFSF11
10 heart disease 31.0 CRP CXCL8 IL10 IL1B IL6 TNF
11 root resorption 30.9 CTSK IL1A IL1B TNFRSF11B TNFSF11
12 human immunodeficiency virus infectious disease 30.9 IL10 IL6 TNF
13 familial mediterranean fever 30.8 CRP IL1B TNF
14 arteries, anomalies of 30.8 CRP IL1B IL6 MMP9 TNF
15 end stage renal failure 30.8 CRP IL6 TNF
16 osteoporosis 30.7 CTSK IL1A IL1B IL6 TNF TNFRSF11B
17 juvenile rheumatoid arthritis 30.7 CRP IL1B IL6 TNF
18 apnea, obstructive sleep 30.5 CRP IL6 TNF
19 ischemic heart disease 30.5 CRP IL6 TNF
20 arthritis 30.5 CXCL8 IL10 IL17A IL1A IL1B IL6
21 autoimmune myocarditis 30.5 IL6 TNF
22 vascular disease 30.5 CRP IL6 MMP9 TNF TNFRSF11B
23 cerebral palsy 30.5 IL1B IL6 MMP8 TNF
24 spondylitis 30.5 CRP IL17A IL6 TNF
25 pulpitis 30.4 CXCL8 IL1A IL1B IL6 MMP1 TNF
26 sleep apnea 30.4 CRP CXCL8 IL1B IL6 TNF
27 purpura 30.4 CRP IL6 TNF
28 atherosclerosis susceptibility 30.4 CDKN2B-AS1 CRP IL6 TLR4 TNF
29 fatty liver disease 30.4 CXCL8 IL1A IL1B IL6 TNF
30 tooth resorption 30.4 CTSK TNFRSF11B TNFSF11
31 hematopoietic stem cell transplantation 30.4 IL10 IL6 TNF
32 placenta disease 30.3 CXCL8 IL1B IL6
33 myocardial infarction 30.3 CDKN2B-AS1 CRP IL10 IL1B IL6 MMP9
34 gingival disease 30.3 IL1A IL1B IL6 MMP1 MMP8
35 aortic valve disease 2 30.3 CRP TNFRSF11B TNFSF11
36 autoimmune disease 30.2 IL10 IL17A IL1B IL6 TNF
37 leprosy 3 30.2 IL10 TLR2 TNF
38 acquired immunodeficiency syndrome 30.2 IL10 IL1B IL6 TNF
39 osteoarthritis 30.2 IL1B IL6 MMP1 TNF
40 osteoporotic fracture 30.2 IL6 TNFRSF11B
41 endometriosis 30.2 CDKN2B-AS1 CXCL8 IL1B IL6
42 spondyloarthropathy 1 30.1 CRP IL17A TLR4 TNF TNFRSF11B
43 esophagitis 30.1 CXCL8 IL1B IL6
44 crohn's colitis 30.1 CXCL8 IL1B TNF
45 duodenal ulcer 30.1 CXCL8 IL1B TNF
46 palindromic rheumatism 30.1 CRP IL1B TNF
47 temporal arteritis 30.1 CRP IL6 TNF
48 fasciitis 30.1 CXCL8 IL6 TNF
49 aortic aneurysm, familial abdominal, 1 30.0 CDKN2B-AS1 MMP1 MMP8 MMP9
50 connective tissue disease 30.0 IL10 IL1A IL6 TNF

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to Periodontitis
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Symptoms & Phenotypes for Periodontitis

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UMLS symptoms related to Periodontitis:


leukorrhea, purulent discharge

GenomeRNAi Phenotypes related to Periodontitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CXCL8 IL10 IL17A IL1A IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CXCL8 IL10 IL17A IL1A IL1B TNF

MGI Mouse Phenotypes related to Periodontitis:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 CRP CTSC CTSK FPR1 IL10 IL17A
2 immune system MP:0005387 10.3 CRP CTSC CTSK FPR1 IL10 IL17A
3 hematopoietic system MP:0005397 10.28 CTSC CTSK FPR1 IL10 IL17A IL1A
4 growth/size/body region MP:0005378 10.23 CTSC CTSK IL10 IL17A IL1B IL6
5 cardiovascular system MP:0005385 10.21 CRP IL10 IL1A IL1B IL6 MMP9
6 digestive/alimentary MP:0005381 10.08 CTSK IL10 IL17A IL6 MMP9 TLR2
7 craniofacial MP:0005382 10.04 CTSK IL10 IL17A IL1B TNF TNFRSF11B
8 integument MP:0010771 10.02 CTSC IL10 IL1A IL1B IL6 MMP9
9 neoplasm MP:0002006 9.9 IL10 IL1A IL1B IL6 MMP1 MMP8
10 limbs/digits/tail MP:0005371 9.8 CTSK IL10 MMP9 TLR4 TNF TNFRSF11B
11 respiratory system MP:0005388 9.61 CTSK IL10 IL17A IL6 MMP9 TLR2
12 skeleton MP:0005390 9.36 CTSK IL10 IL17A IL1B IL6 MMP9
Sources

Drugs & Therapeutics for Periodontitis

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Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 401)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 3,Not Applicable 7681-49-4
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 26787-78-0 33613
3
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 443-48-1 4173
4
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
5
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
6
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
7
Polyestradiol phosphate Approved Phase 4 28014-46-2
8
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
9
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 2713 9552079
10
Coal tar Approved Phase 4,Phase 3,Not Applicable 8007-45-2
11
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 9004-61-9 53477741
12
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
13
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
14
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
15
Hexetidine Approved, Investigational Phase 4 141-94-6
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 22916-47-8 4189
17
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
18
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Not Applicable 85721-33-1 2764
19
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 10118-90-8 5281021
20
Azithromycin Approved Phase 4,Phase 2,Not Applicable 83905-01-5 447043 55185
21
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-78-2 2244
22
Bacitracin Approved, Vet_approved Phase 4,Not Applicable 1405-87-4 10909430 439542
23
Neomycin Approved, Vet_approved Phase 4,Not Applicable 1404-04-2 8378
24
Polymyxin B Approved, Vet_approved Phase 4,Not Applicable 1404-26-8
25
Montelukast Approved Phase 4 158966-92-8 5281040
26
Turmeric Approved, Experimental, Investigational Phase 4,Not Applicable
27
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
28
Pentetic acid Approved Phase 4,Not Applicable 67-43-6
29
Edetic Acid Approved, Vet_approved Phase 4,Not Applicable 60-00-4, 62-33-9 6049
30
Triclosan Approved, Investigational Phase 4,Phase 3 3380-34-5 5564
31
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
32
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
33 Lycopene Approved, Investigational Phase 4,Phase 1,Phase 2 502-65-8 53477748
34
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 564-25-0 54671203
35
Alendronate Approved Phase 4,Phase 2,Phase 3 66376-36-1, 121268-17-5 2088
36
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 137-58-6 3676
37
Zoledronic Acid Approved Phase 4 118072-93-8 68740
38
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81103-11-9 84029
39
Atorvastatin Approved Phase 4,Phase 2,Phase 3 134523-00-5 60823
40
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Not Applicable 15687-27-1 3672
41
Acetaminophen Approved Phase 4,Phase 2,Not Applicable 103-90-2 1983
42
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
43
Povidone Approved Phase 4,Not Applicable 9003-39-8
44
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
45
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
46
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
47
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
48
Methyltestosterone Approved Phase 4 58-18-4 6010
49
Testosterone enanthate Approved Phase 4 315-37-7 9416
50
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013

Interventional clinical trials:

(show top 50) (show all 773)
# Name Status NCT ID Phase Drugs
1 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
2 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
3 Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis Unknown status NCT02735395 Phase 4 Metronidazole 250 (7 days);Metronidazole 400 (7 days);Metronidazole 250 (14 days);Metronidazole 400 (14 days);Amoxicillin
4 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
5 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
6 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
7 Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
8 Treatment of Periodontitis in Obese Individuals Unknown status NCT03103204 Phase 4
9 Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets Unknown status NCT02391974 Phase 4
10 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
11 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
12 Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
13 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
14 Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect Unknown status NCT03146390 Phase 4 Essential oils;Alcohol free essential oils
15 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
16 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
17 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
18 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
19 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
20 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
21 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
22 Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis Completed NCT01034501 Phase 4
23 Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis Completed NCT02014532 Phase 4 Montelukast;Placebo
24 Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment Completed NCT03933501 Phase 4 amoxicillin and metronidazole;Placebos
25 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
26 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
27 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
28 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis Completed NCT02794506 Phase 4 Propolis;Placebo
29 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed NCT02355977 Phase 4 minocycline
30 Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
31 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
32 Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis Completed NCT03419429 Phase 4 Simvastatin
33 Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization Completed NCT00707369 Phase 4 Amoxicillin and Metronidazole;Placebo
34 Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
35 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Completed NCT00297518 Phase 4
36 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. Completed NCT03642353 Phase 4 Triclosan;Placebo
37 Moxifloxacin in Situ Gel to Treat Periodontal Pocket. Completed NCT02016157 Phase 4 Moxifloxacin
38 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
39 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
40 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
41 Melatonin as an Adjunctive Therapy for Chronic Periodontitis. Completed NCT03368430 Phase 4 Placebo
42 Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease Completed NCT02901743 Phase 4
43 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours Completed NCT02215460 Phase 4 FMS chlorhexidine rinse;FMS placebo rinse;FMS azithromycin tablets;FMS placebo tablets;QS azithromycin tablets;QS placebo tablets;QS chlorhexidine rinse;QS placebo rinse
44 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
45 Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
46 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling Completed NCT03498404 Phase 4
47 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
48 The Effects of Periodontal Therapy on Glycemic Control in Diabetic Patients Completed NCT03783845 Phase 4 amoxicillin and metronidazole
49 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
50 The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis Completed NCT02023840 Phase 4 metronidazole gel;placebo

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: periodontitis

Sources

Genetic Tests for Periodontitis

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Genetic tests related to Periodontitis:

# Genetic test Affiliating Genes
1 Periodontitis 30
Sources

Anatomical Context for Periodontitis

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MalaCards organs/tissues related to Periodontitis:

42
Bone, Neutrophil, Heart, Testes, Kidney, Endothelial, T Cells
Sources

Publications for Periodontitis

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Articles related to Periodontitis:

(show top 50) (show all 6065)
# Title Authors Year
1
Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis. ( 30303256 )
2019
2
Assessment of microRNA-146a in generalized aggressive periodontitis and its association with disease severity. ( 30328616 )
2019
3
Comparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis. ( 30350903 )
2019
4
Effect of periodontal treatment on Aggregatibacter actinomycetemcomitans colonization and serum IgG levels against A. actinomycetemcomitans serotypes and Omp29 of aggressive periodontitis patients. ( 30506613 )
2019
5
6-months Clinical Outcomes of Non-Surgical Periodontal Treatment with Antibiotics on Apoptosis Markers in Aggressive Periodontitis. ( 30614174 )
2019
6
One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis. ( 30684915 )
2019
7
Protein carbonyl levels in serum, saliva and gingival crevicular fluid in patients with chronic and aggressive periodontitis. ( 30705565 )
2019
8
Comparison of the oral microbiome of patients with generalized aggressive periodontitis and periodontitis-free subjects. ( 30710838 )
2019
9
A Double-Crown Concept for Restorations in Patients with Generalized Aggressive Periodontitis: Two Case Reports with 22- and 25-Year Follow-ups. ( 30794256 )
2019
10
Regeneration of the Periodontal Apparatus in Aggressive Periodontitis Patients. ( 30857253 )
2019
11
Response to "Identification of genetic risk factors of aggressive periodontitis using genome-wide association studies in association with those of chronic periodontitis". ( 30900245 )
2019
12
Management of periodontic-endodontic lesion in aggressive periodontitis-9 months follow-up: Report of a case. ( 30900677 )
2019
13
Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls. ( 30909081 )
2019
14
Comparison of Subgingival and Buccal Mucosa Microbiome in Chronic and Aggressive Periodontitis: A Pilot Study. ( 30915280 )
2019
15
Periodontal Regeneration with Enamel Matrix Derivative in the Management of Generalized Aggressive Periodontitis: A Case Report with 11-Year Follow-up and Literature Review. ( 30923688 )
2019
16
Clinical and radiographic peri-implant outcomes of short dental implants placed in posterior jaws of patients with treated generalized aggressive periodontitis: A 3-year follow-up study. ( 30938040 )
2019
17
Periodontal tissue destruction in aggressive periodontitis: Determination of gene or environmental factors. ( 30983842 )
2019
18
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status. ( 31032950 )
2019
19
Aggregatibacter actinomycetemcomitans (Aa) Under the Radar: Myths and Misunderstandings of Aa and Its Role in Aggressive Periodontitis. ( 31040843 )
2019
20
Exome sequencing identifies a novel missense variant in CTSC causing nonsyndromic aggressive periodontitis. ( 31068678 )
2019
21
A novel U-shaped relationship between BMI and risk of generalized aggressive periodontitis in Chinese: A cross-sectional study. ( 29944736 )
2019
22
Validation of reported GLT6D1 (rs1537415), IL10 (rs6667202), and ANRIL (rs1333048) single nucleotide polymorphisms for aggressive periodontitis in a Brazilian population. ( 30030838 )
2019
23
Efficacy of adjunctive photodynamic therapy in the treatment of generalized aggressive periodontitis: A randomized controlled clinical trial. ( 30095173 )
2019
24
Vitamin D deficiency in patients with aggressive periodontitis. ( 30169905 )
2019
25
Effects of tofacitinib on the clinical features of periodontitis in patients with rheumatoid arthritis: two case reports. ( 31020271 )
2019
26
Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. ( 30834192 )
2019
27
Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case-control study. ( 30658685 )
2019
28
Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signalling pathway. ( 30636333 )
2019
29
Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis-A pilot study. ( 30399509 )
2019
30
Chlamydia pneumoniae is present in the dental plaque of periodontitis patients and stimulates an inflammatory response in gingival epithelial cells. ( 30956972 )
2019
31
microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. ( 30125982 )
2019
32
Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4. ( 30189157 )
2019
33
Micro-CT analysis of chronic apical periodontitis induced by several specific pathogens. ( 30734930 )
2019
34
Endothelial Dysfunction Marker Variation in Young Adults with Chronic Apical Periodontitis before and after Endodontic Treatment. ( 30910354 )
2019
35
Periodontitis to dementia or converse? ( 31076670 )
2019
36
Association of Chronic Periodontitis on Alzheimer's Disease or Vascular Dementia. ( 30874308 )
2019
37
Probiotics as an Adjunct Therapy for the Treatment of Halitosis, Dental Caries and Periodontitis. ( 30729452 )
2019
38
Effect of Initial Periodontal Therapy on Serum Nitric Oxide Levels in Chronic Periodontitis Patients with or without Type 2 Diabetes Mellitus. ( 31058635 )
2019
39
Effect of scaling and root planing on gingival crevicular fluid levels of adrenomedullin in chronic periodontitis patients with and without diabetes mellitus type 2: A clinico-biochemical study. ( 31070151 )
2019
40
Evaluation of the Relationship Between Type II Diabetes Mellitus and the Prevalence of Apical Periodontitis in Root-Filled Teeth Using Cone Beam Computed Tomography: An Observational Cross-Sectional Study. ( 30999319 )
2019
41
Relevance of single-nucleotide polymorphism to the expression of resistin gene affecting serum and gingival crevicular fluid resistin levels in chronic periodontitis and type 2 diabetes mellitus: A randomized control clinical trial. ( 30983784 )
2019
42
Correlation between Diabetes Mellitus and Periodontitis in Taiwan: A Nationwide Cohort Study. ( 30880092 )
2019
43
Proinflammatory (CD14+CD16++) monocytes in type 2 diabetes mellitus patients with/without chronic periodontitis. ( 30820203 )
2019
44
Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus. ( 30755772 )
2019
45
A comparative evaluation of the micronutrient profile in the serum of diabetes mellitus Type II patients and healthy individuals with periodontitis. ( 30692737 )
2019
46
Quantitative gingival crevicular fluid proteome in type 2 diabetes mellitus and chronic periodontitis. ( 30362201 )
2019
47
The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled trial. ( 30328031 )
2019
48
Cyclosporine A - Induced gingival overgrowth and proliferating cell nuclear antigen expression in experimental periodontitis. ( 30386719 )
2019
49
Characterization and comparison of neutrophil extracellular traps in gingival samples of periodontitis and gingivitis: A pilot study. ( 30298590 )
2019
50
Evidence-Based Update on Diagnosis and Management of Gingivitis and Periodontitis. ( 30447793 )
2019
Sources

Variations for Periodontitis

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ClinVar genetic disease variations for Periodontitis:

6 (show all 32)
# Gene Variation Type Significance SNP ID Assembly Location
1 FPR1 NM_002029.3(FPR1): c.993C> T (p.Thr331=) single nucleotide variant Benign rs17849971 GRCh38 Chromosome 19, 51746002: 51746002
2 FPR1 NM_002029.3(FPR1): c.993C> T (p.Thr331=) single nucleotide variant Benign rs17849971 GRCh37 Chromosome 19, 52249255: 52249255
3 FPR1 NM_002029.3(FPR1): c.488G> A (p.Arg163His) single nucleotide variant Benign rs111768566 GRCh38 Chromosome 19, 51746507: 51746507
4 FPR1 NM_002029.3(FPR1): c.488G> A (p.Arg163His) single nucleotide variant Benign rs111768566 GRCh37 Chromosome 19, 52249760: 52249760
5 FPR1 NM_002029.3(FPR1): c.306T> C (p.Phe102=) single nucleotide variant Benign rs28930680 GRCh38 Chromosome 19, 51746689: 51746689
6 FPR1 NM_002029.3(FPR1): c.306T> C (p.Phe102=) single nucleotide variant Benign rs28930680 GRCh37 Chromosome 19, 52249942: 52249942
7 FPR1 NM_002029.3(FPR1): c.26C> T (p.Thr9Met) single nucleotide variant Likely benign rs148095693 GRCh38 Chromosome 19, 51746969: 51746969
8 FPR1 NM_002029.3(FPR1): c.26C> T (p.Thr9Met) single nucleotide variant Likely benign rs148095693 GRCh37 Chromosome 19, 52250222: 52250222
9 FPR1 NM_002029.3(FPR1): c.348C> T (p.Ile116=) single nucleotide variant Benign rs5030879 GRCh37 Chromosome 19, 52249900: 52249900
10 FPR1 NM_002029.3(FPR1): c.348C> T (p.Ile116=) single nucleotide variant Benign rs5030879 GRCh38 Chromosome 19, 51746647: 51746647
11 FPR1 NM_002029.3(FPR1): c.177C> T (p.Val59=) single nucleotide variant Benign rs61736491 GRCh37 Chromosome 19, 52250071: 52250071
12 FPR1 NM_002029.3(FPR1): c.177C> T (p.Val59=) single nucleotide variant Benign rs61736491 GRCh38 Chromosome 19, 51746818: 51746818
13 FPR1 NM_002029.3(FPR1): c.1037_1038delAGinsCA (p.Glu346Ala) indel Benign rs1555796329 GRCh38 Chromosome 19, 51745957: 51745958
14 FPR1 NM_002029.3(FPR1): c.1037_1038delAGinsCA (p.Glu346Ala) indel Benign rs1555796329 GRCh37 Chromosome 19, 52249210: 52249211
15 FPR1 NM_002029.3(FPR1): c.827A> G (p.Tyr276Cys) single nucleotide variant Uncertain significance rs1555796364 GRCh38 Chromosome 19, 51746168: 51746168
16 FPR1 NM_002029.3(FPR1): c.827A> G (p.Tyr276Cys) single nucleotide variant Uncertain significance rs1555796364 GRCh37 Chromosome 19, 52249421: 52249421
17 FPR1 NM_002029.3(FPR1): c.806G> A (p.Arg269His) single nucleotide variant Benign rs142210016 GRCh37 Chromosome 19, 52249442: 52249442
18 FPR1 NM_002029.3(FPR1): c.806G> A (p.Arg269His) single nucleotide variant Benign rs142210016 GRCh38 Chromosome 19, 51746189: 51746189
19 FPR1 NM_002029.3(FPR1): c.674C> T (p.Ala225Val) single nucleotide variant Uncertain significance rs141913828 GRCh38 Chromosome 19, 51746321: 51746321
20 FPR1 NM_002029.3(FPR1): c.674C> T (p.Ala225Val) single nucleotide variant Uncertain significance rs141913828 GRCh37 Chromosome 19, 52249574: 52249574
21 FPR1 NM_002029.3(FPR1): c.289C> A (p.Leu97Met) single nucleotide variant Benign rs78488639 GRCh37 Chromosome 19, 52249959: 52249959
22 FPR1 NM_002029.3(FPR1): c.289C> A (p.Leu97Met) single nucleotide variant Benign rs78488639 GRCh38 Chromosome 19, 51746706: 51746706
23 FPR1 NM_002029.3(FPR1): c.645C> T (p.Ser215=) single nucleotide variant Benign rs35264765 GRCh38 Chromosome 19, 51746350: 51746350
24 FPR1 NM_002029.3(FPR1): c.645C> T (p.Ser215=) single nucleotide variant Benign rs35264765 GRCh37 Chromosome 19, 52249603: 52249603
25 FPR1 NM_002029.3(FPR1): c.117C> T (p.Leu39=) single nucleotide variant Benign rs149382837 GRCh38 Chromosome 19, 51746878: 51746878
26 FPR1 NM_002029.3(FPR1): c.117C> T (p.Leu39=) single nucleotide variant Benign rs149382837 GRCh37 Chromosome 19, 52250131: 52250131
27 FPR1 NM_002029.3(FPR1): c.805C> T (p.Arg269Cys) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 52249443: 52249443
28 FPR1 NM_002029.3(FPR1): c.805C> T (p.Arg269Cys) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 51746190: 51746190
29 FPR1 NM_002029.3(FPR1): c.409C> T (p.Arg137Cys) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 52249839: 52249839
30 FPR1 NM_002029.3(FPR1): c.409C> T (p.Arg137Cys) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 51746586: 51746586
31 FPR1 NM_002029.3(FPR1): c.534T> A (p.Phe178Leu) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 51746461: 51746461
32 FPR1 NM_002029.3(FPR1): c.534T> A (p.Phe178Leu) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 52249714: 52249714
Sources

Expression for Periodontitis

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Search GEO for disease gene expression data for Periodontitis.
Sources

Pathways for Periodontitis

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Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.98 CRP CTSC CTSK CXCL8 FPR1 IL10
2
PEDF Induced Signaling 65
Show member pathways
 13.77 CXCL8 IL10 IL17A IL1A IL1B IL6
3
Akt Signaling 65
Show member pathways
 13.53 CXCL8 IL10 IL17A IL1A IL1B IL6
4
Cytokine Signaling in Immune system 67
Show member pathways
 13.46 CXCL8 FPR1 IL10 IL17A IL1A IL1B
5
PAK Pathway 65
Show member pathways
 13.39 CXCL8 IL10 IL17A IL1A IL1B IL6
6
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 13.23 CTSK CXCL8 IL10 IL1B IL6 TLR2
7
Human cytomegalovirus infection 38
Show member pathways
 13.06 CXCL8 IL1B IL6 MMP9 TLR2 TLR4
8
Allograft rejection 38 1
Show member pathways
 12.99 CXCL8 IL10 IL17A IL1A IL1B IL6
9
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.82 CXCL8 IL1B IL6 TLR4 TNF
10
NF-KappaB Family Pathway 65
Show member pathways
 12.81 IL1A IL1B IL6 TLR2 TLR4 TNF
11
TRAF Pathway 65
Show member pathways
 12.76 IL1A IL1B TLR2 TLR4 TNF TNFRSF11B
12
Th17 cell differentiation 38
Show member pathways
 12.73 IL10 IL17A IL1A IL1B IL6 TLR2
13
T cell receptor signaling pathway 38
Show member pathways
 12.71 IL10 IL17A IL1A IL1B IL6 TNF
14
NF-kappaB Signaling 4
12.69 IL10 IL17A IL1B TLR2 TNF TNFSF11
15
Immune response IL-23 signaling pathway 23
Show member pathways
 12.67 IL10 IL17A IL1B IL6 TNF
16
RANK Signaling in Osteoclasts 65
Show member pathways
 12.46 CTSK IL10 TNFRSF11B TNFSF11
17
Toll Comparative Pathway 65
Show member pathways
 12.46 CXCL8 IL1A IL1B IL6 TLR4 TNF
18
IL-17 Family Signaling Pathways 66
Show member pathways
 12.44 CXCL8 IL17A IL1B IL6 MMP1 MMP9
19
Diseases associated with the TLR signaling cascade 67
Show member pathways