MCID: PRD008
MIFTS: 61

Periodontitis

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
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Aliases & Classifications for Periodontitis

MalaCards integrated aliases for Periodontitis:

Name: Periodontitis 11 75 28 5 43 14 16 71 75
Chronic Pericementitis 11
Chronic Periodontitis 71

Classifications:



External Ids:

Disease Ontology 11 DOID:824
MeSH 43 D010518
NCIt 49 C34918
SNOMED-CT 68 266491004
ICD10 31 K05.3
UMLS 71 C0031099 C0266929

Summaries for Periodontitis

MalaCards based summary: Periodontitis, also known as chronic pericementitis, is related to periodontitis, chronic and periodontitis, aggressive, 1, and has symptoms including leukorrhea and purulent discharge. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Sodium fluoride and Menthol have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia: 75 Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the... more...

Related Diseases for Periodontitis

Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1339)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 33.4 TNFSF11 MMP8 MMP1 IL6 IL1B
2 periodontitis, aggressive, 1 33.3 MMP8 MMP1 IL1A CTSC
3 chronic apical periodontitis 32.8 TNFSF11 TNF MMP8 IL6 IL1B
4 periapical periodontitis 32.8 TNFSF11 TNF TLR2 MMP9 MMP8 IL6
5 acute pericementitis 32.7 TNFSF11 MMP8 IL6 IL1B CXCL8
6 aggressive periodontitis 32.5 TNFSF11 TNF TLR4 TLR2 PDON2 MMP8
7 suppurative periapical periodontitis 32.5 SIGLEC5 IL6 IL1B CXCL8
8 necrotizing ulcerative gingivitis 32.4 IL6 IL1B CXCL8
9 gingivitis 31.8 TNF TLR2 MMP9 MMP8 MMP1 IL6
10 gingival recession 31.7 TNFSF11 TNF MMP8 IL6 IL1B
11 pulpitis 31.3 TNF MMP1 IL6 IL1B IL1A CXCL8
12 adult syndrome 31.3 TNF IL6 CRP
13 gingival disease 31.3 TNFSF11 TNF TLR4 TLR2 SIGLEC5 MMP9
14 leptin deficiency or dysfunction 31.2 TNF IL6 IL1B IL10 CRP
15 chronic kidney disease 31.2 TNFSF11 TNF IL6 IL1B CRP
16 lipid metabolism disorder 31.2 TNF TLR4 IL6 IL1B IL10 CRP
17 gingival overgrowth 31.2 TNF MMP8 MMP1 IL6 IL1A IL10
18 cardiovascular system disease 31.2 TNF TLR4 TLR2 IL6 IL17A CRP
19 type 2 diabetes mellitus 31.2 TNF TLR4 TLR2 MMP9 IL6 IL4
20 root resorption 31.1 TNFSF11 MMP9 IL6 IL4 IL1B IL1A
21 atherosclerosis susceptibility 31.1 TNF TLR4 MMP9 IL6 IL1B IL10
22 arteries, anomalies of 31.1 TNF IL6 IL1B CRP
23 type 1 diabetes mellitus 31.1 TNFSF11 TNF IL6 IL4 IL1B IL17A
24 gestational diabetes 31.0 TNF IL6 IL1B CRP
25 mucositis 31.0 TLR4 IL1B IL10
26 non-alcoholic fatty liver disease 31.0 TNF TLR4 IL6 IL1B CRP
27 diabetes mellitus 31.0 TNFSF11 TNF TLR4 TLR2 MMP9 MMP1
28 bowel dysfunction 31.0 TNF IL6 IL1B IL10 CRP
29 actinomycosis 31.0 TNF IL10 CRP
30 henoch-schoenlein purpura 31.0 TNF IL6 CRP
31 rheumatoid arthritis 31.0 TNFSF11 TNF TLR4 TLR2 MMP9 MMP8
32 peripheral vascular disease 30.9 TNF IL6 IL1B CRP
33 alcohol use disorder 30.9 TNF TLR4 IL6 IL1B CRP
34 kidney disease 30.9 TNFSF11 TNF IL6 IL1B IL10 CXCL8
35 alzheimer disease, familial, 1 30.9 TNF TLR4 TLR2 IL6 IL1B IL1A
36 periapical granuloma 30.9 TNFSF11 TLR2 MMP8 IL4 CXCL8
37 arthritis 30.9 TNFSF11 TNF TLR4 TLR2 MMP9 MMP8
38 angina pectoris 30.9 TNF IL6 CRP
39 apnea, obstructive sleep 30.9 TNF IL6 IL1B IL10 CXCL8 CRP
40 deficiency anemia 30.9 TNF IL6 IL1B IL10 CRP
41 stomatitis 30.9 TNF IL6 IL4 IL1B IL10 CXCL8
42 amyloidosis 30.9 TNF IL6 IL1B CRP
43 stroke, ischemic 30.9 TNF TLR4 MMP9 IL6 IL1B CRP
44 cerebrovascular disease 30.9 TNF IL6 IL1B CRP
45 autoimmune disease 30.8 TNF TLR4 MMP9 IL6 IL4 IL1B
46 osteonecrosis 30.8 MMP9 IL17A IL10
47 histiocytosis 30.8 TNF IL4 IL17A
48 pre-eclampsia 30.8 TNF TLR4 MMP9 IL6 IL4 IL1B
49 acquired immunodeficiency syndrome 30.8 TNF IL6 IL1B IL10 CRP
50 sleep apnea 30.8 TNF MMP9 IL6 IL1B IL10 CXCL8

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to Periodontitis

Symptoms & Phenotypes for Periodontitis

UMLS symptoms related to Periodontitis:


leukorrhea; purulent discharge

MGI Mouse Phenotypes related to Periodontitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 CRP CTSC IL10 IL17A IL1A IL1B
2 immune system MP:0005387 10.22 CRP CTSC IL10 IL17A IL1A IL1B
3 neoplasm MP:0002006 10.17 IL10 IL1A IL1B IL6 MMP1 MMP8
4 digestive/alimentary MP:0005381 9.97 IL10 IL17A IL4 IL6 MMP9 TLR2
5 respiratory system MP:0005388 9.96 IL10 IL17A IL4 IL6 MMP9 SIGLEC5
6 skeleton MP:0005390 9.85 IL10 IL17A IL1B IL4 IL6 MMP9
7 hematopoietic system MP:0005397 9.77 CTSC IL10 IL17A IL1A IL1B IL4
8 integument MP:0010771 9.4 CTSC IL10 IL17A IL1A IL1B IL4

Drugs & Therapeutics for Periodontitis

Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 376)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium fluoride Approved Phase 4 7681-49-4
2
Menthol Approved, Experimental Phase 4 1490-04-6, 2216-51-5, 15356-60-2 1254 16666 165675
3
Moxifloxacin Approved, Investigational Phase 4 186826-86-8, 354812-41-2, 151096-09-2 152946
4
Metronidazole Approved Phase 4 443-48-1, 69198-10-3 4173
5
Azithromycin Approved Phase 4 83905-01-5 447043
6
Curcumin Approved, Investigational Phase 4 458-37-7, 84765-67-3 969516
7
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
8
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
9
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
10
Simvastatin Approved Phase 4 79902-63-9 54454
11
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
12
Metamfetamine Approved, Illicit, Withdrawn Phase 4 537-46-2 10836
13
Acetylsalicylic acid Approved, Vet_approved Phase 4 50-78-2 2244
14
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
15
Licorice Approved Phase 4
16
Ethanol Approved Phase 4 64-17-5 702
17
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
18
Montelukast Approved Phase 4 158966-92-8 5281040
19
Clarithromycin Approved Phase 4 81103-11-9 84029
20
Alendronic acid Approved Phase 4 121268-17-5, 66376-36-1 2088
21
Lovastatin Approved, Investigational Phase 4 75330-75-5 53232
22
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
23
Turmeric Approved, Experimental, Investigational Phase 4
24
Lycopene Approved, Investigational Phase 4 502-65-8 446925
25
Zoledronic acid Approved Phase 4 118072-93-8 68740
26
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
27
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
28
Ofloxacin Approved Phase 4 82419-36-1 4583
29
Acetaminophen Approved Phase 4 103-90-2 1983
30
Coal tar Approved Phase 4 8007-45-2
31
Hexetidine Approved, Investigational Phase 4 141-94-6 3607
32
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
33
Minocycline Approved, Investigational Phase 4 10118-90-8, 13614-98-7 54675783 5281021
34
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 4 55-56-1 2713 9552079
35
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
36
Ibuprofen Approved Phase 4 15687-27-1 3672
37
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
38
Erythritol Experimental Phase 4 149-32-6 222285
39
Phenothiazine Experimental, Vet_approved Phase 4 92-84-2 7108
40
Triacetin Experimental Phase 4 102-76-1 5541
41 Protective Agents Phase 4
42 Fluorides Phase 4
43 Listerine Phase 4
44 Immunologic Factors Phase 4
45 Anesthetics, Local Phase 4
46 Antibiotics, Antitubercular Phase 4
47 Mitogens Phase 4
48
Tolonium Chloride Phase 4
49 Norgestimate, ethinyl estradiol drug combination Phase 4
50 Adjuvants, Immunologic Phase 4

Interventional clinical trials:

(show top 50) (show all 1034)
# Name Status NCT ID Phase Drugs
1 Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial Unknown status NCT02735395 Phase 4 Metronidazole 250 (7 days);Metronidazole 400 (7 days);Metronidazole 250 (14 days);Metronidazole 400 (14 days);Amoxicillin
2 Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% (Hyadent BG®) and Enamel Matrix Derivative (Emdogain®) in Periodontal Regeneration: A Randomized Clinical Trial Unknown status NCT04274244 Phase 4 Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML;Enamel Matrix Proteins (Active comparator group)
3 Outcome of Endodontic Treatment in Patient Treated With a Hydraulic Sealer Unknown status NCT04249206 Phase 4
4 Effect of Probiotic Lactobacillus Reuteri-containing Lozenges (Prodentis) on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
5 Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection: Randomized Clinical Trial. Unknown status NCT03863249 Phase 4 ADJUNTIVE ANTIBIOTICS
6 Preparation and Analysis of Material, Biological and Clinical Parameters of Metronidazole-loaded Porous Matrices for Local Periodontitis Treatment Unknown status NCT03791099 Phase 4 Metronidazole
7 Filling of Periodontal Pockets With a Commercially Available Injectable Cross-linked Hyaluronic Acid Dental Filler Versus Oral Hygiene Alone, After Scaling and Root Planing and Chlorhexidine Disinfection, for the Treatment of Periodontitis: A Single-blinded, Multi Center, Prospective, Randomized Controlled Trial Unknown status NCT02391974 Phase 4
8 Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis Unknown status NCT00297531 Phase 4
9 Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone Unknown status NCT00296881 Phase 4
10 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
11 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
12 Efficacy of Moxifloxacin, Amoxicillin+Metronidazole for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
13 Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial Unknown status NCT02135952 Phase 4 MTZ+AMX
14 Effects of Tongue Bacterial Dysbiosis Related to Periodontal Therapy on Arterial Pressure Control Based on Salivary Nitrite Availability: a Periodontitis Patients Randomized Controlled Clinical Trial Unknown status NCT04027179 Phase 4 0.12% chlorhexidine digluconate mouthwash;Placebo mouthwash
15 Evaluating the Adjunctive Effect of Stress Reduction Protocol in the Non-Surgical Periodontal Therapy of Chronic Periodontitis Subjects Associated With Stress: A Randomized Control Pilot Study Unknown status NCT02487862 Phase 4
16 Clinical Performance of Two 0.2% Chlorhexidine Mouth Rinses After Periodontal Surgery. A Blinded, Intra-individual Cross-over Clinical Trial Unknown status NCT04223076 Phase 4 Chlorhexidine 0.2%, Corsodyl;Chlorhexidine 0.2%, Curasept
17 Methodology of Application and Immediate Effect of the Essential Oils and 0.2% Chlorhexidine on Oral Biofilm: Immersion Versus Mouthwash. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
18 Essential Oils With and Without Alcohol: in Vivo Antibacterial Effect Unknown status NCT03146390 Phase 4 Essential oils;Alcohol free essential oils
19 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. A Randomized Clinical Trial Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
20 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis: Randomized Clinical Trial Completed NCT03025204 Phase 4
21 Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
22 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole as Adjunctive Therapy to Mechanical Treatment of Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
23 Clinical and Microbiological Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers. Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
24 Long-term Safety Evaluation of Minocycline Resistance After Treatment With Minocycline HCl Microspheres, 1 mg in Subjects With Chronic Periodontitis Completed NCT00668746 Phase 4 Minocycline HCl microspheres
25 The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial) Completed NCT03783845 Phase 4
26 Comparative Evaluation of Treatment Of Infrabony Defects With and Without 1.2% Rosuvastatin Gel: In-Vivo Study Completed NCT03677297 Phase 4 Rosuvastatin
27 Regenerative Potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) Bone Graft in the Treatment of Intrabony Defects; A Comparative Clinico Radiographic Study. Completed NCT04767243 Phase 4 open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
28 Propolis Improves Periodontal Status and Glycemic Control in Subjects With Type 2 Diabetes Mellitus and Chronic Periodontitis: a Randomized Clinical Trial Completed NCT02794506 Phase 4 Propolis;Placebo
29 Clinical, Microbiological and Immunological Effects of Antimicrobial Photodynamic Therapy on Non-surgical Treatment of Aggressive Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial. Completed NCT02049008 Phase 4
30 Effects of Photodynamic Therapy on Clinical and Immunological Parameters in a Group of Periodontal Patients Undergoing Supportive Periodontal Therapy Completed NCT02666573 Phase 4
31 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis: Double-blind Controlled Clinical Trial Completed NCT02125812 Phase 4
32 Efficacy of Locally Delivered Minocycline in Advanced Periodontitis. A Clinico-microbiological Study Completed NCT04076098 Phase 4 Minocycline Hydrochloride
33 Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase Completed NCT04675385 Phase 4 0.2% hyaluronic acid gel
34 Effect of Scaling & Root Planing (SRP) Combined With Therapy Of Omega-3 Fatty Acid on Clinical Parameters and Serum Levels of C-Reactive Protein (CRP) in Chronic Periodontitis - A Randomised Control Trial. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
35 EFFECT OF SRP WITH ADJUNCTIVE THERAPY OF HERBAL IMMUNOMODULATORS ON THE SERUM C REACTIVE PROTEIN (CRP) LEVELS & CLINICAL PARAMETERS IN CHRONIC PERIODONTITIS PATIENTS - A RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED, CLINICAL TRIAL. Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
36 Efficacy of Complex Phytoadaptogenes as an Adjunct to Non-surgical Periodontal Treatment in Patients With Chronic Periodontitis: a Randomized Clinical Trial Completed NCT04623164 Phase 4 Cocktail from complex phytoadaptogens (CFA)
37 Clinical and Microbiological of Antimicrobial Photodynamic Therapy on Surgical Treatment of Chronic Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial. Completed NCT02734784 Phase 4
38 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin: a Clinical Trial Completed NCT02641210 Phase 4 Albendazole
39 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
40 The Effect Of SRP With Adjunctive Systemic Therapy Of Leukotriene Receptor Antagonist-Montelukast On The Serum C Reactive Protein Levels & Clinical Parameters In Chronic Periodontitis Patients - A Randomized Controlled Trial Completed NCT02014532 Phase 4 Montelukast;Placebo
41 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)
42 The Use of Simvastatin Gel With Perforated Resorbable Membranes in the Treatment of Intrabony Defects in Chronic Periodontitis Patients (Clinical and Biochemical Study) Completed NCT03419429 Phase 4 Simvastatin
43 Evaluation of Gingival Crevicular Fluid Interleukin-1β and Interleukin-17 Levels and Periodontal Pathogens After Full-Mouth Disinfection Initial Periodontal Treatment in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and spray
44 The Response of Periodontal Pathogens to the Respective or Combined Treatment of Scaling and Root Planning and Locally Delivered Minocycline in Patients With Chronic Periodontitis- a Short-term Randomized Clinical Trial Completed NCT02355977 Phase 4 minocycline
45 Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial. Completed NCT03368430 Phase 4 Placebo
46 Efficacy of β-glucan in Treatment of Localized Aggressive Periodontitis: A Short Term Double-blinded, Placebo-controlled, Randomized Clinical Trial Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
47 Custom Tray Application of Peroxide Gel as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis: A 6-Month Randomized Trial Completed NCT03262701 Phase 4 Hydrogen Peroxide Gel, 13 weeks;Hydrogen Peroxide Gel, 26 weeks
48 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. A Controlled and Randomized Clinical Trial. Completed NCT03642353 Phase 4 Triclosan;Placebo
49 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
50 Efficacy of Adjunctive Photodynamic Therapy in Non-surgical Treatment of Chronic Periodontitis: a Randomized , Controlled Clinical Trial Completed NCT01034501 Phase 4

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


carbamide peroxide

Cochrane evidence based reviews: periodontitis

Genetic Tests for Periodontitis

Genetic tests related to Periodontitis:

# Genetic test Affiliating Genes
1 Periodontitis 28

Anatomical Context for Periodontitis

Organs/tissues related to Periodontitis:

MalaCards : Bone, Neutrophil, Endothelial, Bone Marrow, Tongue, Heart, Kidney

Publications for Periodontitis

Articles related to Periodontitis:

(show top 50) (show all 30002)
# Title Authors PMID Year
1
Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration. 62
36185747 2023
2
Characterization, Quantification, and Visualization of Neutrophil Extracellular Traps. 62
36418704 2023
3
Saliva Diagnosis Using Small Extracellular Vesicles and Salivaomics. 62
36418680 2023
4
Correlation of salivary visfatin levels in obese and NON-OBESE population with periodontal status. 62
36465888 2023
5
Efficacy confirmation of Scutellaria baicalensis Georgi in the treatment of periodontitis via topical administration and active ingredients screening. 62
36113679 2023
6
Serum metabolomics provides clues in understanding colitis exacerbating experimental periodontitis in female mice. 62
36395563 2023
7
Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissues. 62
35574052 2023
8
Gut microbiota may mediate the impact of chronic apical periodontitis on atherosclerosis in apolipoprotein E-deficient mice. 62
36208054 2023
9
Methods to Study Antagonistic Activities Among Oral Bacteria. 62
36418688 2023
10
Statherin and alpha-amylase levels in saliva from patients with gingivitis and periodontitis. 62
36395562 2023
11
Downregulation of odontogenic ameloblast-associated protein in the progression of periodontal disease affects cell adhesion, proliferation, and migration. 62
36442302 2023
12
Genetic polymorphism in the tumour necrosis factor alpha gene (G-308A) is associated with persistent apical periodontitis in Brazilians. 62
36183324 2023
13
Patient-centric outcome assessment of endodontic microsurgery using periapical radiography versus cone beam computed tomography: A randomized clinical trial. 62
36135595 2023
14
Endodontic Microsurgery of Mandibular Second Molars Using the Bony Lid Approach: A Case Series. 62
36243177 2022
15
Supplementary use of the XP-endo Finisher on postoperative pain in posterior teeth with periapical lesions: a randomized clinical trial. 62
36454357 2022
16
Comparison of EASYDO ACTIVATOR, passive ultrasonic, and needle irrigation techniques on the treatment of apical periodontitis: a study in rats. 62
36053353 2022
17
Pathogenic associations between oral and gastrointestinal diseases. 62
35691866 2022
18
Oral-gut bacterial profiles discriminate between periodontal health and diseases. 62
36261869 2022
19
Oral biofilm dysbiosis during experimental periodontitis. 62
36189827 2022
20
Simple flowcharts for periodontal diagnosis based on the 2018 new periodontal classification increased accuracy and clinician confidence in making a periodontal diagnosis: a randomized crossover trial. 62
35945292 2022
21
Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis. 62
35986791 2022
22
Personality traits, oral health beliefs, and periodontal parameters in patients with periodontitis. 62
36472887 2022
23
Access to dental care barriers and poor clinical oral health in Australian regional populations. 62
35765724 2022
24
Chitosan-based therapeutic systems and their potentials in treatment of oral diseases. 62
36244538 2022
25
Regenerative endodontic treatment of dens in dente in maxillary lateral incisor with immature root: a case report. 62
36416326 2022
26
Role of miRNA-155 in the regulation of osteoclast differentiation mediated by MITF in stage III/IV periodontitis: a case-control study. 62
36459254 2022
27
An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH® and Cytrans® granules for severe periodontitis with intrabony defects. 62
35785043 2022
28
Smoking negatively impacts the clinical, microbiological, and immunological treatment response of young adults with Grade C periodontitis. 62
36050890 2022
29
Digital photometric analysis of gingival response to periodontal treatment. 62
36252859 2022
30
Association of Chronic Systemic Medications with the Incidence, Prevalence, or Healing of Endodontic Disease: A Systematic Review. 62
36244516 2022
31
Colitis induced by dextran sulphate sodium causes histopathological and immunological changes in the periodontal tissues of Wistar rats. 62
36253900 2022
32
The preventive effects of probiotic Akkermansia muciniphila on D-galactose/AlCl3 mediated Alzheimer's disease-like rats. 62
36152776 2022
33
Pilus PilA of the naturally competent HACEK group pathogen Aggregatibacter actinomycetemcomitans stimulates human leukocytes and interacts with both DNA and proinflammatory cytokines. 62
36374775 2022
34
Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions. 62
36453574 2022
35
Effect of vitamin D receptor gene polymorphisms on the risk of chronic and aggressive periodontitis: A systematic review and meta-analysis of the Chinese population. 62
36279828 2022
36
Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony. 62
36067033 2022
37
Altered expression of SOCS genes periodontitis. 62
36456933 2022
38
Mechanisms and Therapeutic Modulation of Neutrophil-Mediated Inflammation. 62
35786033 2022
39
Association of periodontitis with lipid profile: an updated systematic review and meta-analysis. 62
36404817 2022
40
The elevation of fibroblast growth factor 21 is associated with generalized periodontitis in patients with treated metabolic syndrome. 62
36474191 2022
41
Oral health status of adult hypophosphatasia patients: A cross-sectional study. 62
36054522 2022
42
Periodontitis prevalence in patients with ulcerative colitis and Crohn's disease - PPCC: A case-control study. 62
35781889 2022
43
The link between total antioxidant status, total oxidant status, arylesterase activity, and subgingival microbiota in psoriasis patients. 62
35906956 2022
44
Hyper-IgE syndrome caused by DOCK8 mutation with a tumour-like lesion of the lip: a case report. 62
35393256 2022
45
Poor dental health and risk of pancreatic cancer: a nationwide registry-based cohort study in Sweden, 2009-2016. 62
36273086 2022
46
Periodontal Treatment for Chronic Periodontitis With Rheumatoid Arthritis. 62
35810012 2022
47
Emerging technologies and potential applications of algae in dentistry - A critical review. 62
36195207 2022
48
Calcium ions and vitamin B12 are growth factors for Porphyromonas gingivalis. 62
36103977 2022
49
Imipramine prevents Porphyromonas gingivalis lipopolysaccharide-induced microglial neurotoxicity. 62
36240654 2022
50
Coaxial TP/APR electrospun nanofibers for programmed controlling inflammation and promoting bone regeneration in periodontitis-related alveolar bone defect models. 62
36193342 2022

Variations for Periodontitis

ClinVar genetic disease variations for Periodontitis:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 FPR1 NM_002029.4(FPR1):c.534T>A (p.Phe178Leu) SNV Uncertain Significance
566652 rs747450344 GRCh37: 19:52249714-52249714
GRCh38: 19:51746461-51746461
2 FPR1 NM_002029.4(FPR1):c.198C>A (p.Asn66Lys) SNV Uncertain Significance
660315 rs371282377 GRCh37: 19:52250050-52250050
GRCh38: 19:51746797-51746797
3 FPR1 NC_000019.10:g.(?_51745922)_(51759909_?)dup DUP Uncertain Significance
831452 GRCh37: 19:52249175-52263162
GRCh38:
4 FPR1 NM_002029.4(FPR1):c.664G>A (p.Gly222Arg) SNV Uncertain Significance
951604 rs1192119303 GRCh37: 19:52249584-52249584
GRCh38: 19:51746331-51746331
5 FPR1 NM_002029.4(FPR1):c.497C>T (p.Thr166Ile) SNV Uncertain Significance
966326 rs2083746502 GRCh37: 19:52249751-52249751
GRCh38: 19:51746498-51746498
6 CTSK NM_000396.4(CTSK):c.905G>A (p.Trp302Ter) SNV Uncertain Significance
684727 rs1571122183 GRCh37: 1:150769360-150769360
GRCh38: 1:150796884-150796884
7 FPR1 NM_002029.4(FPR1):c.1037_1038delinsCA (p.Glu346Ala) INDEL Benign
526513 rs1555796329 GRCh37: 19:52249210-52249211
GRCh38: 19:51745957-51745958

Expression for Periodontitis

Search GEO for disease gene expression data for Periodontitis.

Pathways for Periodontitis

Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 CRP CTSC CXCL8 IL10 IL17A IL1A
2
Show member pathways
13.87 CXCL8 IL10 IL17A IL1A IL1B IL4
3
Show member pathways
13.74 CXCL8 IL10 IL17A IL1A IL1B IL4
4
Show member pathways
13.59 TNF IL6 IL4 IL1B IL1A IL17A
5
Show member pathways
13.52 CXCL8 IL10 IL17A IL1A IL1B IL4
6
Show member pathways
13.44 TNFSF11 TNF MMP9 MMP1 IL6 IL4
7
Show member pathways
13.41 TNFSF11 TNF IL6 IL4 IL1B IL1A
8
Show member pathways
12.99 TNF TLR4 TLR2 MMP9 IL6 IL1B
9
Show member pathways
12.81 TNF TLR4 TLR2 IL6 IL1B IL1A
10
Show member pathways
12.78 TNF IL6 IL4 IL1B IL1A IL17A
11
Show member pathways
12.73 IL1A IL1B TLR2 TLR4 TNF TNFSF11
12
Show member pathways
12.73 TNF TLR2 IL6 IL1B IL1A CXCL8
13 12.72 IL10 IL17A IL1B IL4 TLR2 TNF
14
Show member pathways
12.66 TNF IL6 IL1B IL17A IL10
15
Show member pathways
12.66 CXCL8 IL1B IL6 TLR2 TLR4 TNF
16
Show member pathways
12.55 CXCL8 IL1A IL1B IL4 IL6 TLR2
17
Show member pathways
12.46 TNF TLR4 IL6 IL1B IL1A CXCL8
18
Show member pathways
12.44 TNF TLR2 MMP9 MMP1 IL6 IL17A
19 12.35 TNF TLR4 TLR2 MMP9 MMP1 IL6
20 12.33 TNF IL6 IL1B IL1A IL10 CXCL8
21 12.26 TNF IL6 IL4 IL1B IL1A IL10
22
Show member pathways
12.22 TNF IL4 IL17A IL10
23
Show member pathways
12.11 TLR4 TLR2 IL1B IL1A
24 12.09 TNF IL6 IL4 IL10
25
Show member pathways
12.07 TNF TLR4 TLR2 IL6 IL1B IL17A
26 12.04 CXCL8 IL1A IL1B IL6
27
Show member pathways
12.04 TLR4 TLR2 IL6 IL4 IL1B IL17A
28
Show member pathways
12.02 TNF MMP9 MMP8 MMP1
29 12.02 TNF IL4 IL1B IL1A IL17A IL10
30
Show member pathways
11.98 TLR4 IL6 IL17A CXCL8
31 11.97 TNF IL4 IL1B IL17A IL10
32 11.91 CRP IL10 IL4 IL6 TLR4 TNF
33 11.89 MMP1 IL6 IL4 CXCL8
34 11.89 MMP9 MMP1 IL6 IL4 IL10 CXCL8
35 11.88 TLR4 MMP9 IL6 IL10
36 11.88 TNF TLR4 MMP9 MMP1 IL6 IL1B
37 11.87 TNF IL6 IL1B IL10
38 11.84 IL6 IL4 IL1B IL17A
39 11.84 TNF MMP9 IL6 IL4 IL1B CXCL8
40 11.83 TNF TLR4 IL6 IL1A IL10 CXCL8
41
Show member pathways
11.82 IL6 CXCL8 CRP
42 11.82 TNF TLR4 MMP9 IL6 IL4 IL1B
43
Show member pathways
11.75 TNF IL4 CXCL8
44 11.71 MMP9 MMP1 CXCL8
45
Show member pathways
11.71 TNF MMP9 MMP1 IL6 IL1B IL1A
46 11.7 TNF TLR4 IL6 CXCL8
47 11.69 TNF IL6 IL1B IL1A IL10 CXCL8
48 11.68 TNFSF11 TNF IL6 IL1B IL1A
49 11.67 TNF TLR4 TLR2 IL1B
50 11.66 MMP1 IL6 CXCL8

GO Terms for Periodontitis

Cellular components related to Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 CRP CTSC CXCL8 IL10 IL17A IL1A
2 extracellular space GO:0005615 9.74 TNFSF11 TNF MMP9 MMP8 IL6 IL4

Biological processes related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.64 IL10 IL17A IL1A IL1B IL4 IL6
2 apoptotic process GO:0006915 10.53 TNF TLR2 MMP9 IL1B IL1A IL17A
3 negative regulation of cell population proliferation GO:0008285 10.44 CXCL8 IL10 IL1A IL1B IL6 TLR2
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.38 TNFSF11 TNF TLR4 IL1B IL1A
5 positive regulation of inflammatory response GO:0050729 10.31 TNF TLR4 TLR2 IL1B
6 positive regulation of DNA-binding transcription factor activity GO:0051091 10.3 TNFSF11 TNF IL6 IL1B IL10
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.28 TNFSF11 TNF TLR4 TLR2 IL6 IL1B
8 inflammatory response GO:0006954 10.28 TNF TLR4 TLR2 IL6 IL1B IL1A
9 positive regulation of MAP kinase activity GO:0043406 10.27 TNFSF11 TNF TLR4 IL1B
10 positive regulation of interleukin-1 beta production GO:0032731 10.26 IL17A IL6 TLR4 TNF
11 defense response to Gram-positive bacterium GO:0050830 10.26 TNF TLR2 IL6 IL1B IL17A CRP
12 JNK cascade GO:0007254 10.24 IL1B TLR4 TNF TNFSF11
13 positive regulation of tumor necrosis factor production GO:0032760 10.23 IL17A IL1A IL6 MMP8 TLR2 TLR4
14 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 10.21 TNF MMP9 IL10
15 positive regulation of interleukin-12 production GO:0032735 10.21 TLR4 TLR2 IL17A
16 positive regulation of cytokine production GO:0001819 10.21 TNF IL1B IL1A IL10
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.21 IL1B MMP8 TLR2 TLR4 TNF
18 collagen catabolic process GO:0030574 10.2 MMP1 MMP8 MMP9
19 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.19 IL10 IL6 TNF
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.19 IL1A IL1B TNF
21 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 10.19 IL4 IL1B IL1A
22 I-kappaB kinase/NF-kappaB signaling GO:0007249 10.19 TNFSF11 TNF TLR4 IL1B
23 positive regulation of nitric oxide biosynthetic process GO:0045429 10.19 TNF TLR4 MMP8 IL1B
24 positive regulation of interleukin-8 production GO:0032757 10.19 TNF TLR4 TLR2 IL6 IL1B
25 positive regulation of mitotic nuclear division GO:0045840 10.18 TNF IL1B IL1A
26 liver regeneration GO:0097421 10.18 TNF IL6 IL10
27 positive regulation of interleukin-10 production GO:0032733 10.18 TLR4 TLR2 IL6 IL4
28 positive regulation of JNK cascade GO:0046330 10.18 TNFSF11 TNF TLR4 MMP8 IL1B IL1A
29 cellular response to lipopolysaccharide GO:0071222 10.18 CXCL8 IL10 IL1A IL1B IL6 TLR4
30 positive regulation of vascular endothelial growth factor production GO:0010575 10.17 IL6 IL1B IL1A
31 lipopolysaccharide-mediated signaling pathway GO:0031663 10.17 TNF TLR4 TLR2 IL1B
32 microglial cell activation GO:0001774 10.16 IL4 TLR2 TNF
33 negative regulation of neurogenesis GO:0050768 10.16 TNF IL6 IL1B
34 positive regulation of osteoclast differentiation GO:0045672 10.15 TNFSF11 TNF IL17A
35 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.15 TNF TLR4 IL6 IL17A
36 positive regulation of glial cell proliferation GO:0060252 10.14 TNF IL6 IL1B
37 response to lipopolysaccharide GO:0032496 10.13 TNF TLR4 TLR2 IL1B IL1A IL10
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.12 TNF IL1B IL10
39 positive regulation of MHC class II biosynthetic process GO:0045348 10.11 TLR4 IL4 IL10
40 regulation of neuroinflammatory response GO:0150077 10.09 MMP9 MMP8 IL6
41 positive regulation of chemokine production GO:0032722 10.09 TNF TLR4 TLR2 IL6 IL1B
42 negative regulation of lipid storage GO:0010888 10.07 CRP IL6 TNF
43 positive regulation of interleukin-6 production GO:0032755 10.06 TNF TLR4 TLR2 MMP8 IL6 IL1B
44 positive regulation of oxidative stress-induced neuron death GO:1903223 10.04 TNF TLR4
45 positive regulation of immature T cell proliferation in thymus GO:0033092 10.03 IL1B IL1A
46 positive regulation of mononuclear cell migration GO:0071677 10.03 TNF IL4
47 negative regulation of cytokine production involved in immune response GO:0002719 10.03 TNF IL10
48 vascular endothelial growth factor production GO:0010573 10.03 IL1B IL6 TNF
49 intestinal epithelial structure maintenance GO:0060729 10.02 TLR4 IL17A
50 positive regulation of fever generation GO:0031622 10.02 TNF IL1B

Molecular functions related to Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.55 TNFSF11 TNF IL6 IL4 IL1B IL1A
2 lipopolysaccharide immune receptor activity GO:0001875 9.26 TLR4 TLR2

Sources for Periodontitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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