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MCID: PRD008
MIFTS: 66

Periodontitis

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Periodontitis

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MalaCards integrated aliases for Periodontitis:

Name: Periodontitis 12 76 29 6 44 15 73
Chronic Pericementitis 12
Chronic Periodontitis 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:824
ICD10 33 K05.3
MeSH 44 D010518
NCIt 50 C34918
SNOMED-CT 68 41565005
Sources

Summaries for Periodontitis

About this section
MalaCards based summary : Periodontitis, also known as chronic pericementitis, is related to periapical periodontitis and periodontitis, chronic, and has symptoms including snoring, halitosis and tenderness of gums. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs sodium fluoride and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the... more...

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Related Diseases for Periodontitis

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Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 757)
# Related Disease Score Top Affiliating Genes
1 periapical periodontitis 33.9 IL1B IL6 MMP8 TLR2 TNF TNFRSF11B
2 periodontitis, chronic 33.9 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
3 aggressive periodontitis 33.4 CTSC CXCL8 FPR1 IL10 IL1A IL1B
4 periodontosis 33.1 CXCL8 MMP9 TLR4 TNF TNFSF11
5 periodontal disease 32.8 CRP CTSC CXCL8 IL17A IL1A IL1B
6 gingivitis 32.2 CXCL8 IL1A IL1B IL6 MMP8 MMP9
7 diabetes mellitus 31.2 CDKN2B-AS1 CRP IL1A IL1B IL6 TNF
8 bone resorption disease 31.1 IL6 TNFRSF11B TNFSF11
9 gingival overgrowth 31.1 IL1A IL6 MMP1
10 root resorption 30.8 IL1A IL1B TNFRSF11B TNFSF11
11 heart disease 30.6 CRP CXCL8 IL10 IL1B IL6 TNF
12 familial mediterranean fever 30.5 CRP IL1B TNF
13 osteoporosis 30.5 CRP IL1A IL1B IL6 TNF TNFRSF11B
14 arthritis 30.5 CXCL8 IL10 IL17A IL1A IL1B IL6
15 pulpitis 30.3 CXCL8 IL1A IL1B IL6 MMP1 TNF
16 arteries, anomalies of 30.2 CRP IL1B IL6 MMP9 TLR9 TNF
17 apnea, obstructive sleep 30.2 CRP IL6 TNF
18 gingival disease 30.2 IL1A IL1B IL6 MMP1 MMP8
19 vascular disease 30.2 CRP IL6 MMP9 TNF TNFRSF11B
20 fatty liver disease 30.2 CXCL8 IL1A IL1B IL6 TNF
21 sleep apnea 30.1 CRP CXCL8 IL1B IL6 TNF
22 purpura 30.1 CRP IL6 TNF
23 myocardial infarction 30.1 CDKN2B-AS1 CRP IL10 IL1B IL6 MMP9
24 hematopoietic stem cell transplantation 30.0 IL10 IL6 TNF
25 end stage renal failure 30.0 CRP IL6 TNF
26 ischemic heart disease 30.0 CRP IL6 TNF
27 crohn's disease 30.0 CRP IL10 TLR9 TNF
28 atherosclerosis susceptibility 30.0 CDKN2B-AS1 CRP IL6 TLR4 TNF
29 spondylitis 30.0 CRP IL17A IL6 TNF
30 aortic valve disease 2 30.0 CRP TNFRSF11B TNFSF11
31 cerebral palsy 30.0 IL1B IL6 MMP8 TNF
32 juvenile rheumatoid arthritis 29.9 CRP IL1B IL6 TNF
33 osteoporotic fracture 29.9 IL6 TNFRSF11B
34 human immunodeficiency virus infectious disease 29.9 IL10 IL6 TLR9 TNF
35 leprosy 3 29.8 IL10 TLR2 TNF
36 esophagitis 29.8 CXCL8 IL1B IL6
37 crohn's colitis 29.8 CXCL8 IL1B TNF
38 duodenal ulcer 29.8 CXCL8 IL1B TNF
39 palindromic rheumatism 29.8 CRP IL1B TNF
40 temporal arteritis 29.8 CRP IL6 TNF
41 prostatitis 29.8 CXCL8 IL10 IL1B IL6 TNF
42 psoriasis 29.8 CXCL8 IL10 IL17A IL1A IL1B IL6
43 fasciitis 29.8 CXCL8 IL6 TNF
44 pulmonary disease, chronic obstructive 29.8 CRP CXCL8 IL17A IL6 MMP1 MMP9
45 spondyloarthropathy 1 29.8 CRP IL17A TLR4 TNF TNFRSF11B
46 rheumatoid arthritis 29.8 CRP CXCL8 IL10 IL17A IL1A IL1B
47 pyoderma 29.8 CXCL8 MMP1 TNF
48 endocarditis 29.7 CRP CXCL8 IL10 IL6 TLR2 TNF
49 aphthous stomatitis 29.7 IL10 IL1B IL6 TLR2 TNF
50 pulmonary emphysema 29.7 MMP1 MMP8 MMP9

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to Periodontitis
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Symptoms & Phenotypes for Periodontitis

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UMLS symptoms related to Periodontitis:


snoring, halitosis, tenderness of gums, leukorrhea, purulent discharge

GenomeRNAi Phenotypes related to Periodontitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CXCL8 IL10 IL17A IL1A IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CXCL8 IL10 IL17A IL1A IL1B TNF

MGI Mouse Phenotypes related to Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 CRP CTSC FPR1 IL10 IL17A IL1A
2 hematopoietic system MP:0005397 10.25 CTSC FPR1 IL10 IL17A IL1A IL1B
3 immune system MP:0005387 10.25 CRP CTSC FPR1 IL10 IL17A IL1A
4 cardiovascular system MP:0005385 10.16 CRP IL10 IL1A IL1B IL6 MMP9
5 digestive/alimentary MP:0005381 10.03 IL10 IL17A IL6 MMP9 TLR2 TLR4
6 integument MP:0010771 9.96 CTSC IL10 IL1A IL1B IL6 MMP9
7 neoplasm MP:0002006 9.9 IL10 IL1A IL1B IL6 MMP1 MMP8
8 respiratory system MP:0005388 9.56 IL10 IL17A IL6 MMP9 TLR2 TLR4
9 skeleton MP:0005390 9.32 IL10 IL17A IL1B IL6 MMP9 TLR2
Sources

Drugs & Therapeutics for Periodontitis

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Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 382)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 3,Not Applicable 7681-49-4
2
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 443-48-1 4173
3
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 26787-78-0 33613
4
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
5
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
6 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
7
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
8
Polyestradiol phosphate Approved Phase 4 28014-46-2
9
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
10
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 2713 9552079
11
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 9004-61-9 53477741
12
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
13
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
14
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
15
Hexetidine Approved, Investigational Phase 4 141-94-6
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 22916-47-8 4189
17
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Not Applicable 85721-33-1 2764
18
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 10118-90-8 5281021
19
Azithromycin Approved Phase 4,Phase 2,Not Applicable 83905-01-5 55185 447043
20
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-78-2 2244
21
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6
22
Neomycin Approved, Vet_approved Phase 4,Not Applicable 1404-04-2 8378
23
Bacitracin Approved, Vet_approved Phase 4,Not Applicable 1405-87-4 10909430 439542
24
Montelukast Approved Phase 4 158966-92-8 5281040
25
Turmeric Approved, Experimental, Investigational Phase 4,Not Applicable
26
Edetic Acid Approved, Vet_approved Phase 4,Not Applicable 62-33-9, 60-00-4 6049
27
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
28
Pentetic acid Approved Phase 4,Not Applicable 67-43-6
29
Triclosan Approved, Investigational Phase 4,Phase 3 3380-34-5 5564
30
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
31
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
32 Lycopene Approved, Investigational Phase 4,Phase 1,Phase 2 502-65-8 446925
33
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 564-25-0 54671203
34
Alendronate Approved Phase 4,Phase 2,Phase 3 66376-36-1, 121268-17-5 2088
35
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 137-58-6 3676
36
Zoledronic acid Approved Phase 4 118072-93-8 68740
37
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81103-11-9 84029
38
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Not Applicable 15687-27-1 3672
39
Acetaminophen Approved Phase 4,Phase 2,Not Applicable 103-90-2 1983
40
Povidone Approved Phase 4,Not Applicable 9003-39-8
41
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
42
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
43
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
44
Coal tar Approved Phase 4,Phase 3,Not Applicable 8007-45-2
45
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
46
Testosterone enanthate Approved Phase 4 315-37-7 9416
47
Testosterone Approved, Investigational Phase 4 58-22-0 6013
48
Methyltestosterone Approved Phase 4 58-18-4 6010
49
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
50
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 73-31-4 896

Interventional clinical trials:

(show top 50) (show all 731)
# Name Status NCT ID Phase Drugs
1 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
2 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
3 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
4 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
5 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
6 Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
7 Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets Unknown status NCT02391974 Phase 4
8 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
9 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
10 Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
11 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
12 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
13 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
14 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
15 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
16 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
17 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
18 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
19 Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis Completed NCT01034501 Phase 4
20 Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis Completed NCT02014532 Phase 4 Montelukast;Placebo
21 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
22 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
23 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
24 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis Completed NCT02794506 Phase 4 Propolis;Placebo
25 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed NCT02355977 Phase 4 minocycline
26 Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
27 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
28 Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis Completed NCT03419429 Phase 4 Simvastatin
29 Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization Completed NCT00707369 Phase 4 Amoxicillin and Metronidazole;Placebo
30 Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
31 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Completed NCT00297518 Phase 4
32 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. Completed NCT03642353 Phase 4 Triclosan;Placebo
33 Moxifloxacin in Situ Gel to Treat Periodontal Pocket. Completed NCT02016157 Phase 4 Moxifloxacin
34 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
35 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
36 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
37 Melatonin as an Adjunctive Therapy for Chronic Periodontitis. Completed NCT03368430 Phase 4 Placebo
38 Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease Completed NCT02901743 Phase 4
39 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours Completed NCT02215460 Phase 4 FMS chlorhexidine rinse;FMS placebo rinse;FMS azithromycin tablets;FMS placebo tablets;QS azithromycin tablets;QS placebo tablets;QS chlorhexidine rinse;QS placebo rinse
40 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
41 Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
42 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling Completed NCT03498404 Phase 4
43 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
44 The Effects of Periodontal Therapy on Glycemic Control in Diabetic Patients Completed NCT03783845 Phase 4 amoxicillin and metronidazole
45 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
46 The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis Completed NCT02023840 Phase 4 metronidazole gel;placebo
47 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology Completed NCT02030470 Phase 4
48 EFFECT OF SELECTIVE COX-2 INHIBITOR (ETORICOXIB) ALONG WITH SCALING AND ROOT PLANING (SRP) ON CLINICAL PARAMETERS AND SALIVARY LEVEL OF SUPEROXIDE DISMUTASE IN CHRONIC GENERALIZED PERIODONTITIS A DOUBLE-BLIND, PLACEBO-CONTROLLED, DOUBLE-MASKED RANDOMIZED CONTROLLED TRIAL (RCT). Completed NCT02149758 Phase 4 Etoricoxib
49 MTZ Plus AMX in the Treatment of Smokers and Non-smokers Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
50 "Efficacy Of 1.2% Rosuvastatin Gel In The Management Of Infrabony Defects" Completed NCT03677297 Phase 4 Rosuvastatin

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: periodontitis

Sources

Genetic Tests for Periodontitis

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Genetic tests related to Periodontitis:

# Genetic test Affiliating Genes
1 Periodontitis 29
Sources

Anatomical Context for Periodontitis

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MalaCards organs/tissues related to Periodontitis:

41
Bone, Neutrophil, Endothelial, Testes, Kidney, Heart, Liver
Sources

Publications for Periodontitis

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Articles related to Periodontitis:

(show top 50) (show all 4296)
# Title Authors Year
1
Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis-A pilot study. ( 30399509 )
2019
2
microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. ( 30125982 )
2019
3
Cyclosporine A - Induced gingival overgrowth and proliferating cell nuclear antigen expression in experimental periodontitis. ( 30386719 )
2019
4
Evidence-Based Update on Diagnosis and Management of Gingivitis and Periodontitis. ( 30447793 )
2019
5
Interleukin-10 polymorphisms (rs1800871, rs1800872 and rs1800896) and periodontitis risk: A meta-analysis. ( 30343215 )
2019
6
Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis. ( 30384155 )
2019
7
Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: Results obtained from a meta-analysis. ( 30388570 )
2019
8
Effect of non-surgical periodontal therapy on salivary metabolic fingerprint of generalized chronic periodontitis using nuclear magnetic resonance spectroscopy. ( 30396039 )
2019
9
DNA methylation profiles of immune response-related genes in apical periodontitis. ( 29904933 )
2019
10
Prevalence of Periodontitis and Soft Tissue Lesions among Human Immunodeficiency Virus-positive Patients on Antiretroviral Therapy in Raichur Taluk, Karnataka, India. ( 29358533 )
2018
11
Antimicrobial peptide gene expression in periodontitis patients: a pilot study. ( 29446150 )
2018
12
Fulminant presentation of oral mucosal leishmaniasis as severe stomatitis and periodontitis. ( 29380732 )
2018
13
Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan. ( 29734656 )
2018
14
Effect of Initial Periodontal Therapy on Salivary Trefoil Factor (TFF3) in otherwise Healthy Patients with Gingivitis and Chronic Periodontitis. ( 29962757 )
2018
15
Discrepancy of Clinical Parameters between the First and Second Molars Can Help to Differentiate Subjects with Aggressive Periodontitis from Chronic Periodontitis: a Cross-sectional Study Based on a Large Chinese Population. ( 29808177 )
2018
16
Expression of Osteoprotegrin and Osteoclast Level in Chronic Apical Periodontitis Induced with East Java Propolis Extract. ( 29692834 )
2018
17
Diagnosis of aggressive periodontitis: A dilemma? ( 29363676 )
2018
18
Consanguinity increases the risk for aggressive periodontitis. ( 29947052 )
2018
19
Feasibility of using allograft bone with resorbable collagen membrane for alveolar ridge vertical defect augmentation for dental implant placement in Patient with Aggressive Periodontitis: A case report. ( 29942111 )
2018
20
The Subgingival Microbiome of Periodontal Pockets With Different Probing Depths in Chronic and Aggressive Periodontitis: A Pilot Study. ( 29765908 )
2018
21
Periodontal bacteria DNA findings in human cardiac tissue - Is there a link of periodontitis to heart valve disease? ( 29197463 )
2018
22
12 years' preservation of maxillary permanent incisors with cervical root fractures adjacent to aggressive periodontitis: Report of a case. ( 29786703 )
2018
23
Assessment of Lipid Peroxidation Levels and Total Antioxidant Status in Chronic and Aggressive Periodontitis Patients: An in vivo Study. ( 29603700 )
2018
24
<i>Porphyromonas gingivalis</i> , a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice. ( 29422938 )
2018
25
Association of Tumor Necrosis Factor-I+ (TNF-I+) Gene Promoter Polymorphisms with Aggressive and Chronic Periodontitis in Eastern Indian population. ( 29449347 )
2018
26
Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study. ( 29394286 )
2018
27
Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease -Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase. ( 29441048 )
2018
28
Analysis of metabolic profiles of generalized aggressive periodontitis. ( 29974463 )
2018
29
Management of localized aggressive periodontitis: A 30-year follow-up. ( 29930995 )
2018
30
Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis. ( 29980169 )
2018
31
B cell subset distribution is altered in patients with severe periodontitis. ( 29447240 )
2018
32
Definition of aggressive periodontitis in periodontal research. A systematic review. ( 29226356 )
2018
33
Clinical efficacy of subgingivally-delivered 0.75% boric acid gel as an adjunct to mechanotherapy in chronic periodontitis: A randomized, controlled clinical trial. ( 28474437 )
2018
34
Methodological issues in assessing the association between periodontitis and caries among adolescents. ( 29446848 )
2018
35
Independent determinants of periodontitis in Yemeni adults: A case-control study. ( 29963753 )
2018
36
Severe periodontitis and higher cirrhosis mortality. ( 29435316 )
2018
37
Development, optimization and evaluation of curcumin loaded biodegradable crosslinked gelatin film for the effective treatment of periodontitis. ( 29429364 )
2018
38
Are cardiovascular risk parameters and glycemic levels associated with periodontitis in type 2 diabetes patients? A clinical study. ( 29961463 )
2018
39
Radiographic morphology of intrabony defects in the first molars of patients with localized aggressive periodontitis: Comparison with health and chronic periodontitis. ( 29660823 )
2018
40
Classification and diagnosis of aggressive periodontitis. ( 29926487 )
2018
41
Morphometric and histopathological evaluation of the effect of grape seed proanthocyanidin on alveolar bone loss in experimental diabetes and periodontitis. ( 29446089 )
2018
42
Dickkopf-1 may regulate bone coupling by attenuating wnt/I^-catenin signaling in chronic apical periodontitis. ( 29216526 )
2018
43
The effects of a desiccant agent in the treatment of chronic periodontitis: a randomized, controlled clinical trial. ( 28624914 )
2018
44
Patients with chronic periodontitis present increased risk for primary SjAPgren syndrome: a nationwide population-based cohort study. ( 29942713 )
2018
45
Saliva and serum biomarkers in periodontitis and coronary artery disease. ( 29972696 )
2018
46
Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis. ( 29736149 )
2018
47
Indocyanine green-mediated photothermal therapy in treatment of chronic periodontitis: A clinico-microbiological study. ( 29962701 )
2018
48
A novel U-shaped relationship between BMI and risk of generalized aggressive periodontitis in Chinese: A cross-sectional study. ( 29944736 )
2018
49
Clastic cells are absent around the root surface in pulp-exposed periapical periodontitis lesions in mice. ( 29480630 )
2018
50
Comparative evaluation of subgingivally-delivered 1% metformin and Aloe vera gel in the treatment of intrabony defects in chronic periodontitis patients: A randomized, controlled clinical trial. ( 29981205 )
2018
Sources

Variations for Periodontitis

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ClinVar genetic disease variations for Periodontitis:

6 (show all 32)
# Gene Variation Type Significance SNP ID Assembly Location
1 FPR1 NM_002029.3(FPR1): c.993C> T (p.Thr331=) single nucleotide variant Benign rs17849971 GRCh38 Chromosome 19, 51746002: 51746002
2 FPR1 NM_002029.3(FPR1): c.993C> T (p.Thr331=) single nucleotide variant Benign rs17849971 GRCh37 Chromosome 19, 52249255: 52249255
3 FPR1 NM_002029.3(FPR1): c.488G> A (p.Arg163His) single nucleotide variant Benign rs111768566 GRCh38 Chromosome 19, 51746507: 51746507
4 FPR1 NM_002029.3(FPR1): c.488G> A (p.Arg163His) single nucleotide variant Benign rs111768566 GRCh37 Chromosome 19, 52249760: 52249760
5 FPR1 NM_002029.3(FPR1): c.306T> C (p.Phe102=) single nucleotide variant Benign rs28930680 GRCh38 Chromosome 19, 51746689: 51746689
6 FPR1 NM_002029.3(FPR1): c.306T> C (p.Phe102=) single nucleotide variant Benign rs28930680 GRCh37 Chromosome 19, 52249942: 52249942
7 FPR1 NM_002029.3(FPR1): c.26C> T (p.Thr9Met) single nucleotide variant Likely benign rs148095693 GRCh38 Chromosome 19, 51746969: 51746969
8 FPR1 NM_002029.3(FPR1): c.26C> T (p.Thr9Met) single nucleotide variant Likely benign rs148095693 GRCh37 Chromosome 19, 52250222: 52250222
9 FPR1 NM_002029.3(FPR1): c.348C> T (p.Ile116=) single nucleotide variant Benign rs5030879 GRCh37 Chromosome 19, 52249900: 52249900
10 FPR1 NM_002029.3(FPR1): c.348C> T (p.Ile116=) single nucleotide variant Benign rs5030879 GRCh38 Chromosome 19, 51746647: 51746647
11 FPR1 NM_002029.3(FPR1): c.177C> T (p.Val59=) single nucleotide variant Benign rs61736491 GRCh37 Chromosome 19, 52250071: 52250071
12 FPR1 NM_002029.3(FPR1): c.177C> T (p.Val59=) single nucleotide variant Benign rs61736491 GRCh38 Chromosome 19, 51746818: 51746818
13 FPR1 NM_002029.3(FPR1): c.1037_1038delAGinsCA (p.Glu346Ala) indel Benign GRCh38 Chromosome 19, 51745957: 51745958
14 FPR1 NM_002029.3(FPR1): c.1037_1038delAGinsCA (p.Glu346Ala) indel Benign GRCh37 Chromosome 19, 52249210: 52249211
15 FPR1 NM_002029.3(FPR1): c.827A> G (p.Tyr276Cys) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 51746168: 51746168
16 FPR1 NM_002029.3(FPR1): c.827A> G (p.Tyr276Cys) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 52249421: 52249421
17 FPR1 NM_002029.3(FPR1): c.806G> A (p.Arg269His) single nucleotide variant Benign rs142210016 GRCh38 Chromosome 19, 51746189: 51746189
18 FPR1 NM_002029.3(FPR1): c.806G> A (p.Arg269His) single nucleotide variant Benign rs142210016 GRCh37 Chromosome 19, 52249442: 52249442
19 FPR1 NM_002029.3(FPR1): c.674C> T (p.Ala225Val) single nucleotide variant Uncertain significance rs141913828 GRCh38 Chromosome 19, 51746321: 51746321
20 FPR1 NM_002029.3(FPR1): c.674C> T (p.Ala225Val) single nucleotide variant Uncertain significance rs141913828 GRCh37 Chromosome 19, 52249574: 52249574
21 FPR1 NM_002029.3(FPR1): c.289C> A (p.Leu97Met) single nucleotide variant Benign rs78488639 GRCh37 Chromosome 19, 52249959: 52249959
22 FPR1 NM_002029.3(FPR1): c.289C> A (p.Leu97Met) single nucleotide variant Benign rs78488639 GRCh38 Chromosome 19, 51746706: 51746706
23 FPR1 NM_002029.3(FPR1): c.645C> T (p.Ser215=) single nucleotide variant Benign rs35264765 GRCh38 Chromosome 19, 51746350: 51746350
24 FPR1 NM_002029.3(FPR1): c.645C> T (p.Ser215=) single nucleotide variant Benign rs35264765 GRCh37 Chromosome 19, 52249603: 52249603
25 FPR1 NM_002029.3(FPR1): c.117C> T (p.Leu39=) single nucleotide variant Benign rs149382837 GRCh37 Chromosome 19, 52250131: 52250131
26 FPR1 NM_002029.3(FPR1): c.117C> T (p.Leu39=) single nucleotide variant Benign rs149382837 GRCh38 Chromosome 19, 51746878: 51746878
27 FPR1 NM_002029.3(FPR1): c.805C> T (p.Arg269Cys) single nucleotide variant Uncertain significance rs771446051 GRCh37 Chromosome 19, 52249443: 52249443
28 FPR1 NM_002029.3(FPR1): c.805C> T (p.Arg269Cys) single nucleotide variant Uncertain significance rs771446051 GRCh38 Chromosome 19, 51746190: 51746190
29 FPR1 NM_002029.3(FPR1): c.409C> T (p.Arg137Cys) single nucleotide variant Uncertain significance rs139132326 GRCh37 Chromosome 19, 52249839: 52249839
30 FPR1 NM_002029.3(FPR1): c.409C> T (p.Arg137Cys) single nucleotide variant Uncertain significance rs139132326 GRCh38 Chromosome 19, 51746586: 51746586
31 FPR1 NM_002029.3(FPR1): c.534T> A (p.Phe178Leu) single nucleotide variant Uncertain significance rs747450344 GRCh38 Chromosome 19, 51746461: 51746461
32 FPR1 NM_002029.3(FPR1): c.534T> A (p.Phe178Leu) single nucleotide variant Uncertain significance rs747450344 GRCh37 Chromosome 19, 52249714: 52249714
Sources

Expression for Periodontitis

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Search GEO for disease gene expression data for Periodontitis.
Sources

Pathways for Periodontitis

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Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.01 CRP CTSC CXCL8 FPR1 IL10 IL17A
2
PEDF Induced Signaling 64
Show member pathways
 13.77 CXCL8 IL10 IL17A IL1A IL1B IL6
3
Akt Signaling 64
Show member pathways
 13.53 CXCL8 IL10 IL17A IL1A IL1B IL6
4
Cytokine Signaling in Immune system 66
Show member pathways
 13.46 CXCL8 FPR1 IL10 IL17A IL1A IL1B
5
PAK Pathway 64
Show member pathways
 13.39 CXCL8 IL10 IL17A IL1A IL1B IL6
6
Human cytomegalovirus infection 37
Show member pathways
 13.15 CXCL8 IL1B IL6 MMP9 TLR2 TLR4
7
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.15 CXCL8 IL10 IL1B IL6 TLR2 TLR4
8
Allograft rejection 1 37
Show member pathways
 13 CXCL8 IL10 IL17A IL1A IL1B IL6
9
Influenza A 37
Show member pathways
 12.94 CXCL8 IL1A IL1B IL6 TLR2 TLR4
10
NF-KappaB Family Pathway 64
Show member pathways
 12.86 IL1A IL1B IL6 TLR2 TLR4 TLR9
11
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.82 CXCL8 IL1B IL6 TLR4 TNF
12
TRAF Pathway 64
Show member pathways
 12.77 IL1A IL1B TLR2 TLR4 TLR9 TNF
13
Th17 cell differentiation 37
Show member pathways
 12.76 IL10 IL17A IL1A IL1B IL6 TLR2
14
NF-kappaB Signaling 4
12.72 IL10 IL17A IL1B TLR2 TLR9 TNF
15
Immune response IL-23 signaling pathway 22
Show member pathways
 12.67 IL10 IL17A IL1B IL6 TNF
16
T cell receptor signaling pathway 37
Show member pathways
 12.59 IL10 IL17A IL1A IL1B IL6 TNF
17
Toll Comparative Pathway 64
Show member pathways
 12.47 CXCL8 IL1A IL1B IL6 TLR4 TNF
18
IL-17 Family Signaling Pathways 65
Show member pathways
 12.47 CXCL8 IL17A IL1B IL6 MMP1 MMP9
19
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.43 CXCL8 IL10 IL17A IL1A IL1B IL6
20
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.43 CXCL8 IL1A IL6 TLR2 TLR4 TLR9
21
Toxoplasmosis 37
Show member pathways