MCID: PRD008
MIFTS: 64

Periodontitis

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Periodontitis

MalaCards integrated aliases for Periodontitis:

Name: Periodontitis 12 74 29 6 44 15 17 71
Chronic Pericementitis 12
Chronic Periodontitis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:824
MeSH 44 D010518
NCIt 50 C34918
SNOMED-CT 67 266491004
ICD10 32 K05.3
UMLS 71 C0031099 C0266929

Summaries for Periodontitis

MalaCards based summary : Periodontitis, also known as chronic pericementitis, is related to periodontitis, chronic and periodontitis, aggressive, 1, and has symptoms including leukorrhea and purulent discharge. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ethanol and Risedronate have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 74 Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the... more...

Related Diseases for Periodontitis

Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1108)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 33.3 TNFSF11 MMP8 MMP1 IL6 IL1B
2 periodontitis, aggressive, 1 33.2 MMP8 MMP1 IL1A FPR1 CTSC
3 suppurative periapical periodontitis 32.6 IL6 IL1B CXCL8 CRP
4 acute pericementitis 32.4 IL1B CXCL8
5 periapical periodontitis 32.3 TNFSF11 TNF TLR2 MMP9 MMP8 IL6
6 aggressive periodontitis 32.2 TNFSF11 TNF TLR4 TLR2 PDON2 MMP9
7 bone resorption disease 31.8 TNFSF11 TNF IL6 IL1B CTSK CRP
8 gingivitis 31.7 TNF TLR2 MMP9 MMP8 MMP1 IL6
9 gingival recession 31.6 TNFSF11 TNF MMP8 IL6 IL1B
10 dental pulp necrosis 31.3 TNFSF11 TNF IL1B
11 pulpitis 31.2 TNF MMP1 IL6 IL1B IL1A CXCL8
12 gingival overgrowth 31.2 TNF MMP8 MMP1 IL6 IL1A CXCL8
13 atherosclerosis susceptibility 31.1 TNF TLR4 MMP9 IL6 IL1B CXCL8
14 gingival disease 31.1 TNFSF11 TNF TLR4 TLR2 SIGLEC5 MMP9
15 root resorption 31.0 TNFSF11 MMP9 IL6 IL1B IL1A CTSK
16 osteonecrosis 31.0 TNFSF11 TNF IL1B
17 periapical granuloma 30.9 TNFSF11 TLR2 MMP8 CXCL8
18 fatty liver disease 30.9 TNF IL6 IL1B IL1A CXCL8
19 stomatitis 30.9 TNF IL6 IL1B IL10 CXCL8
20 end stage renal disease 30.9 TNF IL6 IL1B IL10 CRP
21 arteries, anomalies of 30.9 TNF MIR146A IL6 IL1B CRP
22 type 1 diabetes mellitus 30.9 TNF TLR4 IL6 IL1B IL10 CXCL8
23 gastritis 30.8 TNF TLR4 IL6 IL1B IL10 CXCL8
24 infective endocarditis 30.8 TNF TLR2 IL6 CRP
25 allergic disease 30.8 TNF TLR4 TLR2 IL6 IL1B
26 pre-eclampsia 30.8 TNF TLR4 MMP9 IL6 IL1B IL10
27 pustulosis of palm and sole 30.8 TNF SIGLEC5 CXCL8 CRP
28 helicobacter pylori infection 30.8 TNF IL1B IL10 CXCL8
29 liver disease 30.7 TNF IL6 IL1B IL1A CXCL8
30 bacterial infectious disease 30.7 TNF TLR4 TLR2 IL6 IL1B IL1A
31 lichen planus 30.7 TNF IL6 IL1B IL10 CXCL8
32 non-alcoholic fatty liver disease 30.7 TNF TLR4 IL6 IL1B IL1A IL10
33 cyclic neutropenia 30.7 TNF IL1B CXCL8
34 proteasome-associated autoinflammatory syndrome 1 30.7 TNF TLR4 TLR2 MMP9 IL6 IL1B
35 chronic kidney disease 30.7 TNFSF11 TNF TLR4 MMP9 IL6 IL1B
36 ulcerative colitis 30.7 TNF TLR4 IL6 IL1B IL10 CXCL8
37 haemophilus influenzae 30.7 TNF TLR2 CXCL8
38 endocarditis 30.7 TNF TLR2 IL6 IL1A IL10 CXCL8
39 sleep apnea 30.7 TNF IL6 IL1B IL10 CXCL8 CRP
40 aortic aneurysm 30.6 MMP9 IL6 CRP CDKN2B-AS1
41 conjunctivitis 30.6 TNF MMP9 IL6 IL10 CXCL8
42 cerebrovascular disease 30.6 TNF TLR4 MMP9 IL6 CRP
43 juvenile rheumatoid arthritis 30.6 TNF IL6 IL1B IL10 CXCL8 CRP
44 type 2 diabetes mellitus 30.6 TNFSF11 TNF TLR4 MMP9 MMP8 MMP1
45 stroke, ischemic 30.6 TNF TLR4 MMP9 IL6 IL1B CRP
46 vascular disease 30.6 TNF TLR4 MMP9 MIR146A IL6 IL1A
47 actinomycosis 30.6 TNF IL6 IL1B IL10 CRP
48 spondyloarthropathy 1 30.6 TNFSF11 TNF TLR4 IL6 CRP
49 peptic ulcer disease 30.6 TNF IL1B IL10 CXCL8
50 arthritis 30.6 TNFSF11 TNF TLR4 TLR2 MMP9 MMP8

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to Periodontitis

Symptoms & Phenotypes for Periodontitis

UMLS symptoms related to Periodontitis:


leukorrhea, purulent discharge

MGI Mouse Phenotypes related to Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 CRP CTSC CTSK FPR1 IL10 IL1A
2 hematopoietic system MP:0005397 10.15 CTSC CTSK FPR1 IL10 IL1A IL1B
3 immune system MP:0005387 10.13 CRP CTSC CTSK FPR1 IL10 IL1A
4 integument MP:0010771 9.85 CTSC IL10 IL1A IL1B IL6 MMP9
5 neoplasm MP:0002006 9.7 IL10 IL1A IL1B IL6 MMP1 MMP8
6 respiratory system MP:0005388 9.23 CTSK IL10 IL6 MMP9 TLR2 TLR4

Drugs & Therapeutics for Periodontitis

Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 376)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
3
Cetylpyridinium Approved Phase 4 7773-52-6
4
Menthol Approved Phase 4 2216-51-5 16666
5
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
6
Lactitol Approved, Investigational Phase 4 585-86-4 157355
7
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
8
Licorice Approved Phase 4
9
Zoledronic Acid Approved Phase 4 118072-93-8 68740
10
Coal tar Approved Phase 4 8007-45-2
11
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
12
Turmeric Approved, Experimental, Investigational Phase 4
13
Lovastatin Approved, Investigational Phase 4 75330-75-5 53232
14
Simvastatin Approved Phase 4 79902-63-9 54454
15
Atorvastatin Approved Phase 4 134523-00-5 60823
16
Racepinephrine Approved Phase 4 329-65-7 838
17
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
18
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
19
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
20 sodium fluoride Approved Phase 4 7681-49-4
21
Montelukast Approved Phase 4 158966-92-8 5281040
22
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
23
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
24
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
25
Polyestradiol phosphate Approved Phase 4 28014-46-2
26
Clarithromycin Approved Phase 4 81103-11-9 84029
27
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
28
Ofloxacin Approved Phase 4 82419-36-1 4583
29
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
30
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
31
Prilocaine Approved Phase 4 721-50-6 4906
32
Hexetidine Approved, Investigational Phase 4 141-94-6
33
Sodium citrate Approved, Investigational Phase 4 68-04-2
34
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
35
Potassium citrate Approved, Investigational, Vet_approved Phase 4 866-84-2
36
Zinc oxide Approved Phase 4 1314-13-2
37
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
38
Eugenol Approved Phase 4 97-53-0 3314
39
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
40
Metronidazole Approved Phase 4 443-48-1 4173
41
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
42
Azithromycin Approved Phase 4 83905-01-5 55185 447043
43
Pentetic acid Approved Phase 4 67-43-6
44
Edetic Acid Approved, Vet_approved Phase 4 60-00-4, 62-33-9 6049
45
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
46
Ibuprofen Approved Phase 4 15687-27-1 3672
47
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
48
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
49
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
50
Imidacloprid Vet_approved Phase 4 105827-78-9 86418

Interventional clinical trials:

(show top 50) (show all 1246)
# Name Status NCT ID Phase Drugs
1 Effect of Probiotic Lactobacillus Reuteri-containing Lozenges (Prodentis) on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
2 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
3 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
4 Preparation and Analysis of Material, Biological and Clinical Parameters of Metronidazole-loaded Porous Matrices for Local Periodontitis Treatment Unknown status NCT03791099 Phase 4 Metronidazole
5 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
6 Filling of Periodontal Pockets With a Commercially Available Injectable Cross-linked Hyaluronic Acid Dental Filler Versus Oral Hygiene Alone, After Scaling and Root Planing and Chlorhexidine Disinfection, for the Treatment of Periodontitis: A Single-blinded, Multi Center, Prospective, Randomized Controlled Trial Unknown status NCT02391974 Phase 4
7 Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis Unknown status NCT00297531 Phase 4
8 Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone Unknown status NCT00296881 Phase 4
9 Evaluating the Adjunctive Effect of Stress Reduction Protocol in the Non-Surgical Periodontal Therapy of Chronic Periodontitis Subjects Associated With Stress: A Randomized Control Pilot Study Unknown status NCT02487862 Phase 4
10 The Efficacy of Cyanoacrylate (PeriAcryl®90 HV) in Its Adhesive Post-Operative Properties on Periodontal Wound Healing and Patient Discomfort After Non-Surgical Periodontal Treatment: A Pilot Randomized Clinical Trial Unknown status NCT02826109 Phase 4
11 Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial Unknown status NCT02135952 Phase 4 MTZ+AMX
12 A Clinical and Radiographic Evaluation of DFDBA (Demineralised Freeze Dried Bone Allograft) With Amniotic Membrane (AM) in the Treatment of Periodontal Osseous Defects-12 Month Randomized Controlled Clinical Trial Unknown status NCT02635529 Phase 4
13 Phase IV Study to Evaluate and Compare the Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Rinse With Regards to Managing Post-surgical Inflammation Associated With Dental Implant Surgery Unknown status NCT02987634 Phase 4
14 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. A Randomized Clinical Trial Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
15 Essential Oils With and Without Alcohol: in Vivo Antibacterial Effect Unknown status NCT03146390 Phase 4 Essential oils;Alcohol free essential oils
16 Methodology of Application and Immediate Effect of the Essential Oils and 0.2% Chlorhexidine on Oral Biofilm: Immersion Versus Mouthwash. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
17 The Treatment of Periodontal Diseases. A Randomized, Blinded, Five Years Follow-up, Four-arm, Placebo Controlled Clinical Intervention Trial Unknown status NCT01318928 Phase 4 Metronidazol
18 Evaluation of Platelet Rich Fibrin Efficacy on Reduction of Periodontal Problems Unknown status NCT01583491 Phase 4
19 Mouthwashes as Positive Modulators of Periodontal Response During Orthodontic Treatment: a 6-month Randomized Placebo Controlled Clinical Trial Unknown status NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
20 Efficacy of Complex Phytoadaptogenes as an Adjunct to Non-surgical Periodontal Treatment in Patients With Chronic Periodontitis: a Randomized Clinical Trial Completed NCT04623164 Phase 4 Cocktail from complex phytoadaptogens (CFA)
21 Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study Completed NCT02808988 Phase 4
22 Efficacy of Adjunctive Photodynamic Therapy in Non-surgical Treatment of Chronic Periodontitis: a Randomized , Controlled Clinical Trial Completed NCT01034501 Phase 4
23 The Use of Erythritol Powder and Locally Derived Metronidazole for the Non-surgical Treatment of Periodontitis: a Split-mouth Randomized Controlled Clinical Trial Completed NCT02023840 Phase 4 metronidazole gel;placebo
24 Effects of Ultrasonic Debridement With PVP-iodine Irrigation on Post-treatment Bacteraemia Compared to Ultrasonic Debridement With Water Completed NCT01647347 Phase 4 Supra- and subgingival rinsing with 10% PVP-iodine
25 Influence of Pre-procedural Oral Rinse in the Induced Bacteremia by Periodontal Instrumentation: a Randomized Clinical Trial Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
26 The Local Application of Curcumin in Conjunction With the Surgical Treatment of Intrabony Periodontal Defects "Controlled Clinical Study With Evaluation of Curcumin Release Profile" Completed NCT04032132 Phase 4 curcumin paste
27 Effects of Application Injectable Platelet-Rich Fibrin (i-PRF) as Adjunct Therapy in the Initial Treatment of Periodontitis Completed NCT04178590 Phase 4 SRP + Injectable Platelet-Rich Fibrin;SRP + placebo
28 Curcumin-Simvastatin Release Profile in the Gingival Crevicular Fluid Following EDTA Root Surface Etching in the Surgical Treatment of Intrabony Periodontal Defects - A Biochemical and Clinical Study Completed NCT04044417 Phase 4 curcumin simvastatin paste;EDTA root conditioning
29 Effect of Scaling & Root Planing (SRP) Combined With Therapy Of Omega-3 Fatty Acid on Clinical Parameters and Serum Levels of C-Reactive Protein (CRP) in Chronic Periodontitis - A Randomised Control Trial. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
30 "Comparative Evaluation Of The Efficacy Of Atorvastatin Gel As An Adjunct To Allografts In The Treatment Of Intrabony Defects" - A Clinico Radiological Study Completed NCT03009097 Phase 4 DFDBA with atorvastatin
31 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
32 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling in Patients With Advanced Chronic Periodontitis Completed NCT03498404 Phase 4
33 Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase Completed NCT04675385 Phase 4 0.2% hyaluronic acid gel
34 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis: Randomized Clinical Trial Completed NCT03025204 Phase 4
35 The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial) Completed NCT03783845 Phase 4
36 Clinical and Microbiological of Antimicrobial Photodynamic Therapy on Surgical Treatment of Chronic Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial. Completed NCT02734784 Phase 4
37 Systemic Lycopene as an Adjunct to Scaling and Rootplaning in Chronic Periodontitis Patients With Type 2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
38 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
39 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin: a Clinical Trial Completed NCT02641210 Phase 4 Albendazole
40 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
41 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
42 Clinical and Microbiological Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers. Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
43 The Effect Of SRP With Adjunctive Systemic Therapy Of Leukotriene Receptor Antagonist-Montelukast On The Serum C Reactive Protein Levels & Clinical Parameters In Chronic Periodontitis Patients - A Randomized Controlled Trial Completed NCT02014532 Phase 4 Montelukast;Placebo
44 EFFECT OF SRP WITH ADJUNCTIVE THERAPY OF HERBAL IMMUNOMODULATORS ON THE SERUM C REACTIVE PROTEIN (CRP) LEVELS & CLINICAL PARAMETERS IN CHRONIC PERIODONTITIS PATIENTS - A RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED, CLINICAL TRIAL. Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
45 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)
46 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
47 The Response of Periodontal Pathogens to the Respective or Combined Treatment of Scaling and Root Planning and Locally Delivered Minocycline in Patients With Chronic Periodontitis- a Short-term Randomized Clinical Trial Completed NCT02355977 Phase 4 minocycline
48 The Use of Simvastatin Gel With Perforated Resorbable Membranes in the Treatment of Intrabony Defects in Chronic Periodontitis Patients (Clinical and Biochemical Study) Completed NCT03419429 Phase 4 Simvastatin
49 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole as Adjunctive Therapy to Mechanical Treatment of Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
50 Propolis Improves Periodontal Status and Glycemic Control in Subjects With Type 2 Diabetes Mellitus and Chronic Periodontitis: a Randomized Clinical Trial Completed NCT02794506 Phase 4 Propolis;Placebo

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


carbamide peroxide

Cochrane evidence based reviews: periodontitis

Genetic Tests for Periodontitis

Genetic tests related to Periodontitis:

# Genetic test Affiliating Genes
1 Periodontitis 29

Anatomical Context for Periodontitis

MalaCards organs/tissues related to Periodontitis:

40
Bone, Neutrophil, Endothelial, T Cells, Tongue, Monocytes, Bone Marrow

Publications for Periodontitis

Articles related to Periodontitis:

(show top 50) (show all 27111)
# Title Authors PMID Year
1
The protective effect of tetrahedral framework nucleic acids on periodontium under inflammatory conditions. 61
33313447 2021
2
Direct MALDI-TOF profiling of gingival crevicular fluid sediments for periodontitis diagnosis. 61
33592711 2021
3
Effect of adjuvant bisphosphonates on treatment of periodontitis: Systematic review with meta-analyses. 61
33537188 2021
4
Quercetin reverses TNF‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway. 61
33537804 2021
5
Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment. 61
33486152 2021
6
Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. 61
33359765 2021
7
CXCL5, CXCL8, and CXCL10 regulation by bacteria and mechanical forces in periodontium. 61
33221386 2021
8
The effect of keratinized mucosa on the severity of peri-implant mucositis differs between periodontally healthy subjects and the general population: a cross-sectional study. 61
32607828 2021
9
Combination of Nonsurgical Endodontic and Vital Pulp Therapy for Management of Mature Permanent Mandibular Molar Teeth with Symptomatic Irreversible Pulpitis and Apical Periodontitis. 61
33091455 2021
10
Palatal root surgery of a maxillary molar using a piezosurgery transantral approach with simultaneous sinus lift grafting: a case report. 61
33012051 2021
11
Studies on antimicrobial peptide-loaded nanomaterial for root caries restorations to inhibit periodontitis related pathogens in periodontitis care. 61
33153344 2021
12
Success, Survival Rate, and Soft Tissue Esthetic of Tooth Autotransplantation. 61
33245974 2021
13
Acceptability of a community health worker intervention to improve the oral health of older Chinese Americans: A pilot study. 61
33368603 2021
14
Preterm birth associated with periodontal and dental indicators: a pilot case-control study in a developing country. 61
31035800 2021
15
Periodontitis and diabetes reshape neuronal dendritic arborization in the thalamus and nucleus oralis in the rat. 61
32810328 2021
16
Use of 3-dimensional-Printed Guide in Hemisection and Autotransplantation of a Fusion Tooth: A Case Report. 61
33352149 2021
17
Microcirculation and somatosensory profiling of patients with periodontitis: a preliminary case control report. 61
32613435 2021
18
The influence of apical periodontitis on the concentration of inflammatory mediators in peripheral blood plasma and the metagenomic profiling of endodontic infections: Study design and protocol. 61
33490705 2021
19
Role of Wnt5a in periodontal tissue development, maintenance, and periodontitis: Implications for periodontal regeneration (Review). 61
33398377 2021
20
Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trial. 61
32556659 2021
21
Effect of environmental tobacco smoke on COX-2 and SHP-2 expression in a periodontitis rat model. 61
32640491 2021
22
Salivary and serum markers of angiogenesis in periodontitis in relation to smoking. 61
32643086 2021
23
Pathogenic Microbial Profile and Antibiotic Resistance Associated with Periodontitis. 61
33505093 2021
24
Associations between osteoporosis and risk of periodontitis: A pooled analysis of observational studies. 61
32615008 2021
25
Localisation of citrullinated and carbamylated proteins in inflamed gingival tissues from rheumatoid arthritis patients. 61
32656595 2021
26
Preserving the Neurovascular Bundle in Targeted Endodontic Microsurgery: A Case Series. 61
33096194 2021
27
Four-year Outcome of Nonsurgical Root Canal Retreatment Using Cone-beam Computed Tomography: A Prospective Cohort Study. 61
33130061 2021
28
Effects of melatonin in wound healing of dental pulp and periodontium: Evidence from in vitro, in vivo and clinical studies. 61
33440268 2021
29
Odontogenic causes complicating the chronic rhinosinusitis diagnosis. 61
32500403 2021
30
Diagnostic accuracy of periapical radiograph, cone beam computed tomography, and intrasurgical linear measurement techniques for assessing furcation defects: a longitudinal randomised controlled trial. 61
32535703 2021
31
Probiotic strains of Lactobacillus brevis and Lactobacillus plantarum as adjunct to non-surgical periodontal therapy: 3-month results of a randomized controlled clinical trial. 61
32666349 2021
32
Peripheral memory T-cell profile is modified in patients undergoing periodontal management. 61
33131124 2021
33
Aqueous extract of Chrysanthemum morifolium Ramat. inhibits RANKL-induced osteoclast differentiation by suppressing the c-fos/NFATc1 pathway. 61
33387850 2021
34
Survival rate and potential risk indicators of implant loss in non-smokers and systemically healthy periodontitis patients: An up to 9-year retrospective study. 61
33522612 2021
35
Proteomic analysis of human immunodeficiency virus and periodontitis. 61
33470147 2021
36
Two patients with Papillon-Lefèvre syndrome without periodontal involvement of the permanent dentition. 61
33580910 2021
37
Polymorphisms in the interleukin genes and chronic periodontitis: A field synopsis and revaluation by Bayesian approaches. 61
33223448 2021
38
Efficacy of (-)-epigallocatechin gallate delivered by a new-type scaler tip during scaling and root planing on chronic periodontitis: a split-mouth, randomized clinical trial. 61
33602197 2021
39
Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity. 61
33541200 2021
40
Levels of low-molecular-weight hyaluronan in periodontitis-treated patients and its immunostimulatory effects on CD4+ T lymphocytes. 61
33544199 2021
41
Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms. 61
32034564 2021
42
Cyclophilin A: a key player for etiological agent infection. 61
33492451 2021
43
Effect of preoperative oral administration of steroids in comparison to an anti-inflammatory drug on postoperative pain following single-visit root canal treatment - a double-blind, randomized clinical trial. 61
32976660 2021
44
Association between periodontitis and severity of COVID-19 infection: A case-control study. 61
33527378 2021
45
Assessment of reference areas for superimposition of serial 3D models of patients with advanced periodontitis for volumetric soft tissue evaluation. 61
33576011 2021
46
Relationship between cerebral atrophy and number of present teeth in elderly individuals with cognitive decline. 61
33285222 2021
47
Investigation of Genetic Polymorphisms in BMP2, BMP4, SMAD6, and RUNX2 and Persistent Apical Periodontitis. 61
33245975 2021
48
Prospective clinical investigations of children with periodontal Ehlers-Danlos syndrome identify generalized lack of attached gingiva as a pathognomonic feature. 61
33005042 2021
49
Otolaryngeal and Oropharyngeal Conditions: Common Nontraumatic Dental Conditions. 61
33595265 2021
50
Idiopathic Bone Cavity: Clinicopathologic Features from a Case Series with Emphasis on Differential Diagnosis of Chronic Apical Periodontitis. 61
33217470 2021

Variations for Periodontitis

ClinVar genetic disease variations for Periodontitis:

6 (show top 50) (show all 57)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FPR1 NM_002029.3(FPR1):c.827A>G (p.Tyr276Cys) SNV Uncertain significance 526508 rs1555796364 19:52249421-52249421 19:51746168-51746168
2 FPR1 NM_002029.3(FPR1):c.674C>T (p.Ala225Val) SNV Uncertain significance 526509 rs141913828 19:52249574-52249574 19:51746321-51746321
3 FPR1 NM_002029.3(FPR1):c.534T>A (p.Phe178Leu) SNV Uncertain significance 566652 rs747450344 19:52249714-52249714 19:51746461-51746461
4 FPR1 NM_002029.3(FPR1):c.409C>T (p.Arg137Cys) SNV Uncertain significance 575041 rs139132326 19:52249839-52249839 19:51746586-51746586
5 FPR1 NM_002029.3(FPR1):c.805C>T (p.Arg269Cys) SNV Uncertain significance 575332 rs771446051 19:52249443-52249443 19:51746190-51746190
6 FPR1 NM_002029.3(FPR1):c.559C>T (p.Pro187Ser) SNV Uncertain significance 640589 rs139760904 19:52249689-52249689 19:51746436-51746436
7 FPR1 NM_002029.3(FPR1):c.710G>A (p.Ser237Asn) SNV Uncertain significance 641997 rs1302309228 19:52249538-52249538 19:51746285-51746285
8 FPR1 NM_002029.3(FPR1):c.511A>C (p.Thr171Pro) SNV Uncertain significance 646664 rs771064181 19:52249737-52249737 19:51746484-51746484
9 FPR1 NM_002029.3(FPR1):c.439A>G (p.Ile147Val) SNV Uncertain significance 651669 rs183314714 19:52249809-52249809 19:51746556-51746556
10 FPR1 NM_002029.3(FPR1):c.379G>A (p.Val127Ile) SNV Uncertain significance 652351 rs186613919 19:52249869-52249869 19:51746616-51746616
11 FPR1 NM_002029.3(FPR1):c.274C>A (p.Pro92Thr) SNV Uncertain significance 656419 rs750324912 19:52249974-52249974 19:51746721-51746721
12 FPR1 NM_002029.3(FPR1):c.205G>A (p.Val69Met) SNV Uncertain significance 660114 rs199534146 19:52250043-52250043 19:51746790-51746790
13 FPR1 NM_002029.3(FPR1):c.198C>A (p.Asn66Lys) SNV Uncertain significance 660315 rs371282377 19:52250050-52250050 19:51746797-51746797
14 FPR1 NM_002029.3(FPR1):c.542C>T (p.Ser181Leu) SNV Uncertain significance 660454 rs146075164 19:52249706-52249706 19:51746453-51746453
15 CTSK NM_000396.4(CTSK):c.905G>A (p.Trp302Ter) SNV Uncertain significance 684727 rs1571122183 1:150769360-150769360 1:150796884-150796884
16 FPR1 NC_000019.10:g.(?_51745922)_(51759909_?)dup Duplication Uncertain significance 831452 19:52249175-52263162
17 FPR1 NM_002029.4(FPR1):c.898C>G (p.Leu300Val) SNV Uncertain significance 835264 19:52249350-52249350 19:51746097-51746097
18 FPR1 NM_002029.4(FPR1):c.736G>T (p.Val246Phe) SNV Uncertain significance 836559 19:52249512-52249512 19:51746259-51746259
19 FPR1 NM_002029.4(FPR1):c.40G>A (p.Gly14Arg) SNV Uncertain significance 838179 19:52250208-52250208 19:51746955-51746955
20 FPR1 NM_002029.4(FPR1):c.952G>A (p.Ala318Thr) SNV Uncertain significance 840695 19:52249296-52249296 19:51746043-51746043
21 FPR1 NM_002029.4(FPR1):c.440T>C (p.Ile147Thr) SNV Uncertain significance 841167 19:52249808-52249808 19:51746555-51746555
22 FPR1 NM_002029.4(FPR1):c.79A>G (p.Ile27Val) SNV Uncertain significance 841693 19:52250169-52250169 19:51746916-51746916
23 FPR1 NM_002029.4(FPR1):c.713G>A (p.Arg238His) SNV Uncertain significance 844349 19:52249535-52249535 19:51746282-51746282
24 FPR1 NM_002029.4(FPR1):c.955A>C (p.Ser319Arg) SNV Uncertain significance 847520 19:52249293-52249293 19:51746040-51746040
25 FPR1 NM_002029.4(FPR1):c.934C>T (p.Leu312=) SNV Uncertain significance 848388 19:52249314-52249314 19:51746061-51746061
26 FPR1 NM_002029.4(FPR1):c.613C>T (p.Arg205Trp) SNV Uncertain significance 851750 19:52249635-52249635 19:51746382-51746382
27 FPR1 NM_002029.4(FPR1):c.826T>C (p.Tyr276His) SNV Uncertain significance 852538 19:52249422-52249422 19:51746169-51746169
28 FPR1 NM_002029.4(FPR1):c.570G>C (p.Arg190Ser) SNV Uncertain significance 856172 19:52249678-52249678 19:51746425-51746425
29 FPR1 NM_002029.4(FPR1):c.331G>A (p.Gly111Arg) SNV Uncertain significance 860414 19:52249917-52249917 19:51746664-51746664
30 FPR1 NM_002029.4(FPR1):c.654T>A (p.Ala218=) SNV Uncertain significance 937938 19:52249594-52249594 19:51746341-51746341
31 FPR1 NM_002029.4(FPR1):c.721C>T (p.Arg241Trp) SNV Uncertain significance 938975 19:52249527-52249527 19:51746274-51746274
32 FPR1 NM_002029.4(FPR1):c.596C>T (p.Thr199Met) SNV Uncertain significance 946253 19:52249652-52249652 19:51746399-51746399
33 FPR1 NM_002029.4(FPR1):c.722G>A (p.Arg241Gln) SNV Uncertain significance 950010 19:52249526-52249526 19:51746273-51746273
34 FPR1 NM_002029.4(FPR1):c.664G>A (p.Gly222Arg) SNV Uncertain significance 951604 19:52249584-52249584 19:51746331-51746331
35 FPR1 NM_002029.4(FPR1):c.823A>G (p.Met275Val) SNV Uncertain significance 952169 19:52249425-52249425 19:51746172-51746172
36 FPR1 NM_002029.4(FPR1):c.751T>C (p.Phe251Leu) SNV Uncertain significance 956161 19:52249497-52249497 19:51746244-51746244
37 FPR1 NM_002029.4(FPR1):c.943G>A (p.Ala315Thr) SNV Uncertain significance 958537 19:52249305-52249305 19:51746052-51746052
38 FPR1 NM_002029.4(FPR1):c.919G>A (p.Asp307Asn) SNV Uncertain significance 960581 19:52249329-52249329 19:51746076-51746076
39 FPR1 NM_002029.4(FPR1):c.634G>A (p.Ala212Thr) SNV Uncertain significance 963210 19:52249614-52249614 19:51746361-51746361
40 FPR1 NM_002029.4(FPR1):c.160C>T (p.Arg54Trp) SNV Uncertain significance 965936 19:52250088-52250088 19:51746835-51746835
41 FPR1 NM_002029.4(FPR1):c.497C>T (p.Thr166Ile) SNV Uncertain significance 966326 19:52249751-52249751 19:51746498-51746498
42 FPR1 NM_002029.3(FPR1):c.744A>C (p.Ala248=) SNV Likely benign 716687 rs145578657 19:52249504-52249504 19:51746251-51746251
43 FPR1 NM_002029.3(FPR1):c.582C>T (p.Ala194=) SNV Likely benign 726546 rs747540806 19:52249666-52249666 19:51746413-51746413
44 FPR1 NM_002029.3(FPR1):c.607A>G (p.Ile203Val) SNV Likely benign 783851 rs150239733 19:52249641-52249641 19:51746388-51746388
45 FPR1 NM_002029.3(FPR1):c.368G>A (p.Arg123His) SNV Likely benign 785829 rs149931707 19:52249880-52249880 19:51746627-51746627
46 FPR1 NM_002029.3(FPR1):c.26C>T (p.Thr9Met) SNV Likely benign 456364 rs148095693 19:52250222-52250222 19:51746969-51746969
47 FPR1 NM_002029.3(FPR1):c.488G>A (p.Arg163His) SNV Benign 456367 rs111768566 19:52249760-52249760 19:51746507-51746507
48 FPR1 NM_002029.3(FPR1):c.822C>T (p.Gly274=) SNV Benign 712949 rs547725110 19:52249426-52249426 19:51746173-51746173
49 FPR1 NM_002029.3(FPR1):c.117C>T (p.Leu39=) SNV Benign 526510 rs149382837 19:52250131-52250131 19:51746878-51746878
50 FPR1 NM_002029.3(FPR1):c.806G>A (p.Arg269His) SNV Benign 526511 rs142210016 19:52249442-52249442 19:51746189-51746189

Expression for Periodontitis

Search GEO for disease gene expression data for Periodontitis.

Pathways for Periodontitis

Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TNFSF11 TNF TLR4 TLR2 SIGLEC5 MMP9
2
Show member pathways
13.5 TNFSF11 TNF TLR4 TLR2 IL6 IL1B
3
Show member pathways
13.45 TNFSF11 TNF MMP9 MMP1 IL6 IL1B
4
Show member pathways
13.35 TNFSF11 TNF IL6 IL1B IL1A IL10
5
Show member pathways
13.15 TNF TLR4 TLR2 MMP9 IL6 IL1B
6
Show member pathways
13 TNF TLR4 TLR2 IL6 IL1B CXCL8
7
Show member pathways
12.93 TNF IL6 IL1B IL1A IL10 CXCL8
8
Show member pathways
12.93 TNF TLR4 TLR2 IL6 IL1B IL1A
9
Show member pathways
12.84 TNF TLR4 TLR2 IL6 IL1B IL1A
10
Show member pathways
12.83 TNF TLR4 TLR2 IL6 IL1B CXCL8
11
Show member pathways
12.8 TNF TLR4 TLR2 IL6 IL1B IL1A
12
Show member pathways
12.71 TNF TLR4 TLR2 IL6 IL1B IL1A
13
Show member pathways
12.7 TNF TLR4 TLR2 IL6 IL1B IL1A
14
Show member pathways
12.69 TNFSF11 TNF TLR4 TLR2 IL1B IL1A
15 12.64 TNFSF11 TNF TLR2 IL1B IL10
16 12.44 TNF TLR4 IL1B CXCL8
17
Show member pathways
12.44 TNF TLR4 IL6 IL1B IL1A CXCL8
18
Show member pathways
12.43 TNF TLR2 MMP9 MMP1 IL6 IL1B
19
Show member pathways
12.39 TNF TLR4 TLR2 IL6 IL1A CXCL8
20
Show member pathways
12.39 TNF TLR4 TLR2 IL1B IL1A IL10
21
Show member pathways
12.38 TNF IL6 IL10 CXCL8
22
Show member pathways
12.38 TNF IL6 IL1B CRP
23
Show member pathways
12.37 TNF IL6 IL1B IL1A IL10 CXCL8
24 12.35 TNF TLR4 TLR2 MMP9
25 12.35 TNF TLR4 IL6 IL1B CXCL8
26 12.34 TNF TLR4 TLR2 IL6 IL1B IL1A
27 12.31 TNF TLR4 TLR2 MMP9 MMP1 IL6
28
Show member pathways
12.31 TNF TLR4 TLR2 IL6 IL1B CXCL8
29 12.29 TNF IL6 IL1B