Periodontitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRD008 MIFTS: 64	Periodontitis Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Periodontitis

MalaCards integrated aliases for Periodontitis:

Name: Periodontitis ¹² ⁷⁴ ²⁹ ⁶ ⁴⁴ ¹⁵ ¹⁷ ⁷¹

Chronic Pericementitis ¹²

Chronic Periodontitis ⁷¹

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases Gastrointestinal diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the digestive system

Diseases of oral cavity, salivary glands and jaws

Gingivitis and periodontal diseases

Chronic periodontitis

External Ids:

Disease Ontology ¹² DOID:824

MeSH ⁴⁴ D010518

NCIt ⁵⁰ C34918

SNOMED-CT ⁶⁷ 266491004

ICD10 ³² K05.3

EFO ¹⁷ EFO_0000649

UMLS ⁷¹ C0031099 C0266929

Sources

Summaries for Periodontitis

MalaCards based summary : Periodontitis, also known as chronic pericementitis, is related to periodontitis, chronic and periodontitis, aggressive, 1, and has symptoms including leukorrhea and purulent discharge. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ethanol and Risedronate have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : ⁷⁴ Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the... more...

Sources

Related Diseases for Periodontitis

Diseases in the Periodontitis family:

Periodontitis, Chronic

Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1108)

#	Related Disease	Score	Top Affiliating Genes
1	periodontitis, chronic	33.3	TNFSF11 MMP8 MMP1 IL6 IL1B
2	periodontitis, aggressive, 1	33.2	MMP8 MMP1 IL1A FPR1 CTSC
3	suppurative periapical periodontitis	32.6	IL6 IL1B CXCL8 CRP
4	acute pericementitis	32.4	IL1B CXCL8
5	periapical periodontitis	32.3	TNFSF11 TNF TLR2 MMP9 MMP8 IL6
6	aggressive periodontitis	32.2	TNFSF11 TNF TLR4 TLR2 PDON2 MMP9
7	bone resorption disease	31.8	TNFSF11 TNF IL6 IL1B CTSK CRP
8	gingivitis	31.7	TNF TLR2 MMP9 MMP8 MMP1 IL6
9	gingival recession	31.6	TNFSF11 TNF MMP8 IL6 IL1B
10	dental pulp necrosis	31.3	TNFSF11 TNF IL1B
11	pulpitis	31.2	TNF MMP1 IL6 IL1B IL1A CXCL8
12	gingival overgrowth	31.2	TNF MMP8 MMP1 IL6 IL1A CXCL8
13	atherosclerosis susceptibility	31.1	TNF TLR4 MMP9 IL6 IL1B CXCL8
14	gingival disease	31.1	TNFSF11 TNF TLR4 TLR2 SIGLEC5 MMP9
15	root resorption	31.0	TNFSF11 MMP9 IL6 IL1B IL1A CTSK
16	osteonecrosis	31.0	TNFSF11 TNF IL1B
17	periapical granuloma	30.9	TNFSF11 TLR2 MMP8 CXCL8
18	fatty liver disease	30.9	TNF IL6 IL1B IL1A CXCL8
19	stomatitis	30.9	TNF IL6 IL1B IL10 CXCL8
20	end stage renal disease	30.9	TNF IL6 IL1B IL10 CRP
21	arteries, anomalies of	30.9	TNF MIR146A IL6 IL1B CRP
22	type 1 diabetes mellitus	30.9	TNF TLR4 IL6 IL1B IL10 CXCL8
23	gastritis	30.8	TNF TLR4 IL6 IL1B IL10 CXCL8
24	infective endocarditis	30.8	TNF TLR2 IL6 CRP
25	allergic disease	30.8	TNF TLR4 TLR2 IL6 IL1B
26	pre-eclampsia	30.8	TNF TLR4 MMP9 IL6 IL1B IL10
27	pustulosis of palm and sole	30.8	TNF SIGLEC5 CXCL8 CRP
28	helicobacter pylori infection	30.8	TNF IL1B IL10 CXCL8
29	liver disease	30.7	TNF IL6 IL1B IL1A CXCL8
30	bacterial infectious disease	30.7	TNF TLR4 TLR2 IL6 IL1B IL1A
31	lichen planus	30.7	TNF IL6 IL1B IL10 CXCL8
32	non-alcoholic fatty liver disease	30.7	TNF TLR4 IL6 IL1B IL1A IL10
33	cyclic neutropenia	30.7	TNF IL1B CXCL8
34	proteasome-associated autoinflammatory syndrome 1	30.7	TNF TLR4 TLR2 MMP9 IL6 IL1B
35	chronic kidney disease	30.7	TNFSF11 TNF TLR4 MMP9 IL6 IL1B
36	ulcerative colitis	30.7	TNF TLR4 IL6 IL1B IL10 CXCL8
37	haemophilus influenzae	30.7	TNF TLR2 CXCL8
38	endocarditis	30.7	TNF TLR2 IL6 IL1A IL10 CXCL8
39	sleep apnea	30.7	TNF IL6 IL1B IL10 CXCL8 CRP
40	aortic aneurysm	30.6	MMP9 IL6 CRP CDKN2B-AS1
41	conjunctivitis	30.6	TNF MMP9 IL6 IL10 CXCL8
42	cerebrovascular disease	30.6	TNF TLR4 MMP9 IL6 CRP
43	juvenile rheumatoid arthritis	30.6	TNF IL6 IL1B IL10 CXCL8 CRP
44	type 2 diabetes mellitus	30.6	TNFSF11 TNF TLR4 MMP9 MMP8 MMP1
45	stroke, ischemic	30.6	TNF TLR4 MMP9 IL6 IL1B CRP
46	vascular disease	30.6	TNF TLR4 MMP9 MIR146A IL6 IL1A
47	actinomycosis	30.6	TNF IL6 IL1B IL10 CRP
48	spondyloarthropathy 1	30.6	TNFSF11 TNF TLR4 IL6 CRP
49	peptic ulcer disease	30.6	TNF IL1B IL10 CXCL8
50	arthritis	30.6	TNFSF11 TNF TLR4 TLR2 MMP9 MMP8

Graphical network of the top 20 diseases related to Periodontitis:

Sources

Symptoms & Phenotypes for Periodontitis

UMLS symptoms related to Periodontitis:

leukorrhea, purulent discharge

MGI Mouse Phenotypes related to Periodontitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.2	CRP CTSC CTSK FPR1 IL10 IL1A
2	hematopoietic system	MP:0005397	10.15	CTSC CTSK FPR1 IL10 IL1A IL1B
3	immune system	MP:0005387	10.13	CRP CTSC CTSK FPR1 IL10 IL1A
4	integument	MP:0010771	9.85	CTSC IL10 IL1A IL1B IL6 MMP9
5	neoplasm	MP:0002006	9.7	IL10 IL1A IL1B IL6 MMP1 MMP8
6	respiratory system	MP:0005388	9.23	CTSK IL10 IL6 MMP9 TLR2 TLR4

Sources

Drugs & Therapeutics for Periodontitis

Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 376)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ethanol

Approved

Phase 4

64-17-5

702

Risedronate

Approved, Investigational

Phase 4

105462-24-6

5245

Cetylpyridinium

Approved

Phase 4

7773-52-6

Menthol

Approved

Phase 4

2216-51-5

16666

Methyl salicylate

Approved, Vet_approved

Phase 4

119-36-8

4133

Lactitol

Approved, Investigational

Phase 4

585-86-4

157355

Aspirin

Approved, Vet_approved

Phase 4

50-78-2

2244

Licorice

Approved

Phase 4

Zoledronic Acid

Approved

Phase 4

118072-93-8

68740

Coal tar

Approved

Phase 4

8007-45-2

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Turmeric

Approved, Experimental, Investigational

Phase 4

Lovastatin

Approved, Investigational

Phase 4

75330-75-5

53232

Simvastatin

Approved

Phase 4

79902-63-9

54454

Atorvastatin

Approved

Phase 4

134523-00-5

60823

Racepinephrine

Approved

Phase 4

329-65-7

838

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Alendronate

Approved

Phase 4

121268-17-5, 66376-36-1

2088

Albendazole

Approved, Vet_approved

Phase 4

54965-21-8

2082

sodium fluoride

Approved

Phase 4

7681-49-4

Montelukast

Approved

Phase 4

158966-92-8

5281040

Ethinyl Estradiol

Approved

Phase 4

57-63-6

5991

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Norgestimate

Approved, Investigational

Phase 4

35189-28-7

6540478

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Clarithromycin

Approved

Phase 4

81103-11-9

84029

Triclosan

Approved, Investigational

Phase 4

3380-34-5

5564

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Etoricoxib

Approved, Investigational

Phase 4

202409-33-4

123619

Prilocaine

Approved

Phase 4

721-50-6

4906

Hexetidine

Approved, Investigational

Phase 4

141-94-6

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

Penicillin V

Approved, Vet_approved

Phase 4

87-08-1

6869

Potassium citrate

Approved, Investigational, Vet_approved

Phase 4

866-84-2

Zinc oxide

Approved

Phase 4

1314-13-2

Moxifloxacin

Approved, Investigational

Phase 4

151096-09-2, 354812-41-2

152946

Eugenol

Approved

Phase 4

97-53-0

3314

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Metronidazole

Approved

Phase 4

443-48-1

4173

Hyaluronic acid

Approved, Vet_approved

Phase 4

9004-61-9

53477741

Azithromycin

Approved

Phase 4

83905-01-5

55185 447043

Pentetic acid

Approved

Phase 4

67-43-6

Edetic Acid

Approved, Vet_approved

Phase 4

60-00-4, 62-33-9

6049

Doxycycline

Approved, Investigational, Vet_approved

Phase 4

564-25-0

54671203

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Melatonin

Approved, Nutraceutical, Vet_approved

Phase 4

73-31-4

896

Aspartic acid

Approved, Nutraceutical

Phase 4

56-84-8

5960

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

Imidacloprid

Vet_approved

Phase 4

105827-78-9

86418

Interventional clinical trials:

(show top 50) (show all 1246)

#	Name	Status	NCT ID	Phase	Drugs
1	Effect of Probiotic Lactobacillus Reuteri-containing Lozenges (Prodentis) on Halitosis in Patients With Chronic Periodontitis	Unknown status	NCT02789436	Phase 4	L. reuteri Prodentis® lozenges
2	Effect of Actonel on Periodontal Health of Postmenopausal Women	Unknown status	NCT00594334	Phase 4	Risedronate
3	Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy	Unknown status	NCT01532674	Phase 4
4	Preparation and Analysis of Material, Biological and Clinical Parameters of Metronidazole-loaded Porous Matrices for Local Periodontitis Treatment	Unknown status	NCT03791099	Phase 4	Metronidazole
5	Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care	Unknown status	NCT01195493	Phase 4
6	Filling of Periodontal Pockets With a Commercially Available Injectable Cross-linked Hyaluronic Acid Dental Filler Versus Oral Hygiene Alone, After Scaling and Root Planing and Chlorhexidine Disinfection, for the Treatment of Periodontitis: A Single-blinded, Multi Center, Prospective, Randomized Controlled Trial	Unknown status	NCT02391974	Phase 4
7	Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis	Unknown status	NCT00297531	Phase 4
8	Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone	Unknown status	NCT00296881	Phase 4
9	Evaluating the Adjunctive Effect of Stress Reduction Protocol in the Non-Surgical Periodontal Therapy of Chronic Periodontitis Subjects Associated With Stress: A Randomized Control Pilot Study	Unknown status	NCT02487862	Phase 4
10	The Efficacy of Cyanoacrylate (PeriAcryl®90 HV) in Its Adhesive Post-Operative Properties on Periodontal Wound Healing and Patient Discomfort After Non-Surgical Periodontal Treatment: A Pilot Randomized Clinical Trial	Unknown status	NCT02826109	Phase 4
11	Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial	Unknown status	NCT02135952	Phase 4	MTZ+AMX
12	A Clinical and Radiographic Evaluation of DFDBA (Demineralised Freeze Dried Bone Allograft) With Amniotic Membrane (AM) in the Treatment of Periodontal Osseous Defects-12 Month Randomized Controlled Clinical Trial	Unknown status	NCT02635529	Phase 4
13	Phase IV Study to Evaluate and Compare the Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Rinse With Regards to Managing Post-surgical Inflammation Associated With Dental Implant Surgery	Unknown status	NCT02987634	Phase 4
14	Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. A Randomized Clinical Trial	Unknown status	NCT02946801	Phase 4	Essential oils;Essential oils without alcohol;Sterile water
15	Essential Oils With and Without Alcohol: in Vivo Antibacterial Effect	Unknown status	NCT03146390	Phase 4	Essential oils;Alcohol free essential oils
16	Methodology of Application and Immediate Effect of the Essential Oils and 0.2% Chlorhexidine on Oral Biofilm: Immersion Versus Mouthwash.	Unknown status	NCT02267239	Phase 4	essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
17	The Treatment of Periodontal Diseases. A Randomized, Blinded, Five Years Follow-up, Four-arm, Placebo Controlled Clinical Intervention Trial	Unknown status	NCT01318928	Phase 4	Metronidazol
18	Evaluation of Platelet Rich Fibrin Efficacy on Reduction of Periodontal Problems	Unknown status	NCT01583491	Phase 4
19	Mouthwashes as Positive Modulators of Periodontal Response During Orthodontic Treatment: a 6-month Randomized Placebo Controlled Clinical Trial	Unknown status	NCT03179735	Phase 4	Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
20	Efficacy of Complex Phytoadaptogenes as an Adjunct to Non-surgical Periodontal Treatment in Patients With Chronic Periodontitis: a Randomized Clinical Trial	Completed	NCT04623164	Phase 4	Cocktail from complex phytoadaptogens (CFA)
21	Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study	Completed	NCT02808988	Phase 4
22	Efficacy of Adjunctive Photodynamic Therapy in Non-surgical Treatment of Chronic Periodontitis: a Randomized , Controlled Clinical Trial	Completed	NCT01034501	Phase 4
23	The Use of Erythritol Powder and Locally Derived Metronidazole for the Non-surgical Treatment of Periodontitis: a Split-mouth Randomized Controlled Clinical Trial	Completed	NCT02023840	Phase 4	metronidazole gel;placebo
24	Effects of Ultrasonic Debridement With PVP-iodine Irrigation on Post-treatment Bacteraemia Compared to Ultrasonic Debridement With Water	Completed	NCT01647347	Phase 4	Supra- and subgingival rinsing with 10% PVP-iodine
25	Influence of Pre-procedural Oral Rinse in the Induced Bacteremia by Periodontal Instrumentation: a Randomized Clinical Trial	Completed	NCT02215473	Phase 4	Chlorhexidine gluconate mouth rinse
26	The Local Application of Curcumin in Conjunction With the Surgical Treatment of Intrabony Periodontal Defects "Controlled Clinical Study With Evaluation of Curcumin Release Profile"	Completed	NCT04032132	Phase 4	curcumin paste
27	Effects of Application Injectable Platelet-Rich Fibrin (i-PRF) as Adjunct Therapy in the Initial Treatment of Periodontitis	Completed	NCT04178590	Phase 4	SRP + Injectable Platelet-Rich Fibrin;SRP + placebo
28	Curcumin-Simvastatin Release Profile in the Gingival Crevicular Fluid Following EDTA Root Surface Etching in the Surgical Treatment of Intrabony Periodontal Defects - A Biochemical and Clinical Study	Completed	NCT04044417	Phase 4	curcumin simvastatin paste;EDTA root conditioning
29	Effect of Scaling & Root Planing (SRP) Combined With Therapy Of Omega-3 Fatty Acid on Clinical Parameters and Serum Levels of C-Reactive Protein (CRP) in Chronic Periodontitis - A Randomised Control Trial.	Completed	NCT01997853	Phase 4	Omega 3 fatty acid;Placebo
30	"Comparative Evaluation Of The Efficacy Of Atorvastatin Gel As An Adjunct To Allografts In The Treatment Of Intrabony Defects" - A Clinico Radiological Study	Completed	NCT03009097	Phase 4	DFDBA with atorvastatin
31	Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients	Completed	NCT02442453	Phase 4	Topical application of curenext gel;Placebo
32	Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling in Patients With Advanced Chronic Periodontitis	Completed	NCT03498404	Phase 4
33	Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase	Completed	NCT04675385	Phase 4	0.2% hyaluronic acid gel
34	Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis: Randomized Clinical Trial	Completed	NCT03025204	Phase 4
35	The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial)	Completed	NCT03783845	Phase 4
36	Clinical and Microbiological of Antimicrobial Photodynamic Therapy on Surgical Treatment of Chronic Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial.	Completed	NCT02734784	Phase 4
37	Systemic Lycopene as an Adjunct to Scaling and Rootplaning in Chronic Periodontitis Patients With Type 2 Diabetes Mellitus	Completed	NCT02263352	Phase 4	Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
38	Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects	Completed	NCT02886676	Phase 4	Spirulina capsules
39	Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin: a Clinical Trial	Completed	NCT02641210	Phase 4	Albendazole
40	"Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial."	Completed	NCT02583841	Phase 4
41	Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis.	Completed	NCT01211223	Phase 4	Administration of Metronidazole plus Amoxicillin
42	Clinical and Microbiological Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers.	Completed	NCT01837199	Phase 4	Metronidazole plus Amoxicillin
43	The Effect Of SRP With Adjunctive Systemic Therapy Of Leukotriene Receptor Antagonist-Montelukast On The Serum C Reactive Protein Levels & Clinical Parameters In Chronic Periodontitis Patients - A Randomized Controlled Trial	Completed	NCT02014532	Phase 4	Montelukast;Placebo
44	EFFECT OF SRP WITH ADJUNCTIVE THERAPY OF HERBAL IMMUNOMODULATORS ON THE SERUM C REACTIVE PROTEIN (CRP) LEVELS & CLINICAL PARAMETERS IN CHRONIC PERIODONTITIS PATIENTS - A RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED, CLINICAL TRIAL.	Completed	NCT01997814	Phase 4	herbal immunomodulator;Placebo
45	Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients	Completed	NCT01647282	Phase 4	locally-applied minocycline HCl (1 mg)
46	Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response	Completed	NCT02197260	Phase 4	3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
47	The Response of Periodontal Pathogens to the Respective or Combined Treatment of Scaling and Root Planning and Locally Delivered Minocycline in Patients With Chronic Periodontitis- a Short-term Randomized Clinical Trial	Completed	NCT02355977	Phase 4	minocycline
48	The Use of Simvastatin Gel With Perforated Resorbable Membranes in the Treatment of Intrabony Defects in Chronic Periodontitis Patients (Clinical and Biochemical Study)	Completed	NCT03419429	Phase 4	Simvastatin
49	Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole as Adjunctive Therapy to Mechanical Treatment of Patients With Chronic Periodontitis	Completed	NCT00805558	Phase 4	moxifloxacin;Ciprofloxacin plus metronidazole
50	Propolis Improves Periodontal Status and Glycemic Control in Subjects With Type 2 Diabetes Mellitus and Chronic Periodontitis: a Randomized Clinical Trial	Completed	NCT02794506	Phase 4	Propolis;Placebo

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵¹ :

carbamide peroxide

Cochrane evidence based reviews: periodontitis

Sources

Genetic Tests for Periodontitis

Genetic tests related to Periodontitis:

#	Genetic test	Affiliating Genes
1	Periodontitis ²⁹

Sources

Anatomical Context for Periodontitis

MalaCards organs/tissues related to Periodontitis:

⁴⁰

Bone, Neutrophil, Endothelial, T Cells, Tongue, Monocytes, Bone Marrow

Sources

Publications for Periodontitis

Articles related to Periodontitis:

(show top 50) (show all 27111)

#	Title	Authors	PMID	Year
1	The protective effect of tetrahedral framework nucleic acids on periodontium under inflammatory conditions. ⁶¹	Zhou M...Cai X	33313447	2021
2	Direct MALDI-TOF profiling of gingival crevicular fluid sediments for periodontitis diagnosis. ⁶¹	Yi J...Wang Y	33592711	2021
3	Effect of adjuvant bisphosphonates on treatment of periodontitis: Systematic review with meta-analyses. ⁶¹	Muniz FWMG...Martins TM	33537188	2021
4	Quercetin reverses TNF‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway. ⁶¹	Zhang W...Xu X	33537804	2021
5	Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment. ⁶¹	Weng Y...Wang Z	33486152	2021
6	Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. ⁶¹	Nakao Y...Nishimura F	33359765	2021
7	CXCL5, CXCL8, and CXCL10 regulation by bacteria and mechanical forces in periodontium. ⁶¹	Rath-Deschner B...Nogueira AVB	33221386	2021
8	The effect of keratinized mucosa on the severity of peri-implant mucositis differs between periodontally healthy subjects and the general population: a cross-sectional study. ⁶¹	Kabir L...Grischke J	32607828	2021
9	Combination of Nonsurgical Endodontic and Vital Pulp Therapy for Management of Mature Permanent Mandibular Molar Teeth with Symptomatic Irreversible Pulpitis and Apical Periodontitis. ⁶¹	Koli B...Sharma S	33091455	2021
10	Palatal root surgery of a maxillary molar using a piezosurgery transantral approach with simultaneous sinus lift grafting: a case report. ⁶¹	Silberman JJ...Sanabria-Liviac D	33012051	2021
11	Studies on antimicrobial peptide-loaded nanomaterial for root caries restorations to inhibit periodontitis related pathogens in periodontitis care. ⁶¹	Hu Y...Wu B	33153344	2021
12	Success, Survival Rate, and Soft Tissue Esthetic of Tooth Autotransplantation. ⁶¹	de Freitas Coutinho NB...Frozoni M	33245974	2021
13	Acceptability of a community health worker intervention to improve the oral health of older Chinese Americans: A pilot study. ⁶¹	Northridge ME...Yi S	33368603	2021
14	Preterm birth associated with periodontal and dental indicators: a pilot case-control study in a developing country. ⁶¹	Marquez-Corona ML...Medina-Solis CE	31035800	2021
15	Periodontitis and diabetes reshape neuronal dendritic arborization in the thalamus and nucleus oralis in the rat. ⁶¹	Flores-Tochihuitl J...Morales-Medina JC	32810328	2021
16	Use of 3-dimensional-Printed Guide in Hemisection and Autotransplantation of a Fusion Tooth: A Case Report. ⁶¹	Sato M...Chen IP	33352149	2021
17	Microcirculation and somatosensory profiling of patients with periodontitis: a preliminary case control report. ⁶¹	Fan R...Wang K	32613435	2021
18	The influence of apical periodontitis on the concentration of inflammatory mediators in peripheral blood plasma and the metagenomic profiling of endodontic infections: Study design and protocol. ⁶¹	Georgiou AC...van der Waal SV	33490705	2021
19	Role of Wnt5a in periodontal tissue development, maintenance, and periodontitis: Implications for periodontal regeneration (Review). ⁶¹	Wei X...Wu Y	33398377	2021
20	Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trial. ⁶¹	Isola G...Leonardi R	32556659	2021
21	Effect of environmental tobacco smoke on COX-2 and SHP-2 expression in a periodontitis rat model. ⁶¹	Li X...Yang D	32640491	2021
22	Salivary and serum markers of angiogenesis in periodontitis in relation to smoking. ⁶¹	Yilmaz Sastim C...Dogan B	32643086	2021
23	Pathogenic Microbial Profile and Antibiotic Resistance Associated with Periodontitis. ⁶¹	Ansiliero R...Locatelli C	33505093	2021
24	Associations between osteoporosis and risk of periodontitis: A pooled analysis of observational studies. ⁶¹	Xu S...Tan YH	32615008	2021
25	Localisation of citrullinated and carbamylated proteins in inflamed gingival tissues from rheumatoid arthritis patients. ⁶¹	Lee YH...Vaithilingam RD	32656595	2021
26	Preserving the Neurovascular Bundle in Targeted Endodontic Microsurgery: A Case Series. ⁶¹	Benjamin G...Diogenes A	33096194	2021
27	Four-year Outcome of Nonsurgical Root Canal Retreatment Using Cone-beam Computed Tomography: A Prospective Cohort Study. ⁶¹	Zhang MM...Liang YH	33130061	2021
28	Effects of melatonin in wound healing of dental pulp and periodontium: Evidence from in vitro, in vivo and clinical studies. ⁶¹	Vaseenon S...Chattipakorn SC	33440268	2021
29	Odontogenic causes complicating the chronic rhinosinusitis diagnosis. ⁶¹	Wuokko-Landen A...Valimaa H	32500403	2021
30	Diagnostic accuracy of periapical radiograph, cone beam computed tomography, and intrasurgical linear measurement techniques for assessing furcation defects: a longitudinal randomised controlled trial. ⁶¹	Yusof NAM...Yusof MYPM	32535703	2021
31	Probiotic strains of Lactobacillus brevis and Lactobacillus plantarum as adjunct to non-surgical periodontal therapy: 3-month results of a randomized controlled clinical trial. ⁶¹	Pudgar P...Gaspersic R	32666349	2021
32	Peripheral memory T-cell profile is modified in patients undergoing periodontal management. ⁶¹	Medara N...O'Brien-Simpson NM	33131124	2021
33	Aqueous extract of Chrysanthemum morifolium Ramat. inhibits RANKL-induced osteoclast differentiation by suppressing the c-fos/NFATc1 pathway. ⁶¹	Jang HY...Lee YR	33387850	2021
34	Survival rate and potential risk indicators of implant loss in non-smokers and systemically healthy periodontitis patients: An up to 9-year retrospective study. ⁶¹	Wang Y...Xie Y	33522612	2021
35	Proteomic analysis of human immunodeficiency virus and periodontitis. ⁶¹	Tsuchida S...Nakayama T	33470147	2021
36	Two patients with Papillon-Lefèvre syndrome without periodontal involvement of the permanent dentition. ⁶¹	Umlauft J...Gruber R	33580910	2021
37	Polymorphisms in the interleukin genes and chronic periodontitis: A field synopsis and revaluation by Bayesian approaches. ⁶¹	da Silva FRP...Pereira ACTDC	33223448	2021
38	Efficacy of (-)-epigallocatechin gallate delivered by a new-type scaler tip during scaling and root planing on chronic periodontitis: a split-mouth, randomized clinical trial. ⁶¹	Wang Y...Luan Q	33602197	2021
39	Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity. ⁶¹	Hasiakos S...Nishimura I	33541200	2021
40	Levels of low-molecular-weight hyaluronan in periodontitis-treated patients and its immunostimulatory effects on CD4+ T lymphocytes. ⁶¹	Castillo F...Vernal R	33544199	2021
41	Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms. ⁶¹	Hallikainen J...Frosen J	32034564	2021
42	Cyclophilin A: a key player for etiological agent infection. ⁶¹	Liao Y...Zeng Y	33492451	2021
43	Effect of preoperative oral administration of steroids in comparison to an anti-inflammatory drug on postoperative pain following single-visit root canal treatment - a double-blind, randomized clinical trial. ⁶¹	Suresh N...Natanasabapathy V	32976660	2021
44	Association between periodontitis and severity of COVID-19 infection: A case-control study. ⁶¹	Marouf N...Tamimi F	33527378	2021
45	Assessment of reference areas for superimposition of serial 3D models of patients with advanced periodontitis for volumetric soft tissue evaluation. ⁶¹	Kuralt M...Fidler A	33576011	2021
46	Relationship between cerebral atrophy and number of present teeth in elderly individuals with cognitive decline. ⁶¹	Egashira R...Naito T	33285222	2021
47	Investigation of Genetic Polymorphisms in BMP2, BMP4, SMAD6, and RUNX2 and Persistent Apical Periodontitis. ⁶¹	Kuchler EC...Baratto-Filho F	33245975	2021
48	Prospective clinical investigations of children with periodontal Ehlers-Danlos syndrome identify generalized lack of attached gingiva as a pathognomonic feature. ⁶¹	Kapferer-Seebacher I...van Dijk FS	33005042	2021
49	Otolaryngeal and Oropharyngeal Conditions: Common Nontraumatic Dental Conditions. ⁶¹	Stoker AJ...Gauer RL	33595265	2021
50	Idiopathic Bone Cavity: Clinicopathologic Features from a Case Series with Emphasis on Differential Diagnosis of Chronic Apical Periodontitis. ⁶¹	Roma LG...Pires FR	33217470	2021

Sources

Genes for Periodontitis

Genes related to Periodontitis (0 elite genes):

(show all 44)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CDKN2B-AS1	CDKN2B Antisense RNA 1	RNA Gene	172.14	Experimental evidence: Expression ³⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)	19214202 23813974
2	CTSC	Cathepsin C	Protein Coding	44.89	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
3	FPR1	Formyl Peptide Receptor 1	Protein Coding	23.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
4	CTSK	Cathepsin K	Protein Coding	22.17	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
5	IL1B	Interleukin 1 Beta	Protein Coding	18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	SIGLEC5	Sialic Acid Binding Ig Like Lectin 5	Protein Coding	17.72	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL6	Interleukin 6	Protein Coding	17.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TNF	Tumor Necrosis Factor	Protein Coding	17.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	TNFSF11	TNF Superfamily Member 11	Protein Coding	17.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	MMP8	Matrix Metallopeptidase 8	Protein Coding	17.04	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	IL1A	Interleukin 1 Alpha	Protein Coding	16.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	16.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	IL10	Interleukin 10	Protein Coding	16.48	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	TLR4	Toll Like Receptor 4	Protein Coding	16.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	TLR2	Toll Like Receptor 2	Protein Coding	16.14	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	CRP	C-Reactive Protein	Protein Coding	16.04	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	MIR146A	MicroRNA 146a	RNA Gene	15.96	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
18	PDON2	Periodontitis, Localized Aggressive	Genetic Locus	15.88	GeneCards inferred via : Publications Gene name (show sections)
19	MMP1	Matrix Metallopeptidase 1	Protein Coding	15.82	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	MMP9	Matrix Metallopeptidase 9	Protein Coding	15.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	IL4	Interleukin 4	Protein Coding	15.77	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	IL17A	Interleukin 17A	Protein Coding	15.72	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	IFNG	Interferon Gamma	Protein Coding	15.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	15.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
25	SERPINA3	Serpin Family A Member 3	Protein Coding	15.01	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
26	MMP2	Matrix Metallopeptidase 2	Protein Coding	14.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
27	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	14.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
28	MMP3	Matrix Metallopeptidase 3	Protein Coding	14.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
29	ELANE	Elastase, Neutrophil Expressed	Protein Coding	14.84	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
30	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	14.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
31	DEFB1	Defensin Beta 1	Protein Coding	14.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
32	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	14.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
33	MMP13	Matrix Metallopeptidase 13	Protein Coding	14.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
34	IL18	Interleukin 18	Protein Coding	14.67	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
35	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	14.65	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
36	GLT6D1	Glycosyltransferase 6 Domain Containing 1	Protein Coding	14.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
37	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	14.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
38	MIR125A	MicroRNA 125a	RNA Gene	14.48	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
39	MIR21	MicroRNA 21	RNA Gene	14.46	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
40	VDR	Vitamin D Receptor	Protein Coding	14.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
41	IL2	Interleukin 2	Protein Coding	14.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
42	FCGR2A	Fc Fragment Of IgG Receptor IIa	Protein Coding	14.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
43	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	14.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
44	DEFB4A	Defensin Beta 4A	Protein Coding	14.32	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Periodontitis

ClinVar genetic disease variations for Periodontitis:

⁶ (show top 50) (show all 57)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	FPR1	NM_002029.3(FPR1):c.827A>G (p.Tyr276Cys)	SNV	Uncertain significance	526508	rs1555796364	19:52249421-52249421	19:51746168-51746168
2	FPR1	NM_002029.3(FPR1):c.674C>T (p.Ala225Val)	SNV	Uncertain significance	526509	rs141913828	19:52249574-52249574	19:51746321-51746321
3	FPR1	NM_002029.3(FPR1):c.534T>A (p.Phe178Leu)	SNV	Uncertain significance	566652	rs747450344	19:52249714-52249714	19:51746461-51746461
4	FPR1	NM_002029.3(FPR1):c.409C>T (p.Arg137Cys)	SNV	Uncertain significance	575041	rs139132326	19:52249839-52249839	19:51746586-51746586
5	FPR1	NM_002029.3(FPR1):c.805C>T (p.Arg269Cys)	SNV	Uncertain significance	575332	rs771446051	19:52249443-52249443	19:51746190-51746190
6	FPR1	NM_002029.3(FPR1):c.559C>T (p.Pro187Ser)	SNV	Uncertain significance	640589	rs139760904	19:52249689-52249689	19:51746436-51746436
7	FPR1	NM_002029.3(FPR1):c.710G>A (p.Ser237Asn)	SNV	Uncertain significance	641997	rs1302309228	19:52249538-52249538	19:51746285-51746285
8	FPR1	NM_002029.3(FPR1):c.511A>C (p.Thr171Pro)	SNV	Uncertain significance	646664	rs771064181	19:52249737-52249737	19:51746484-51746484
9	FPR1	NM_002029.3(FPR1):c.439A>G (p.Ile147Val)	SNV	Uncertain significance	651669	rs183314714	19:52249809-52249809	19:51746556-51746556
10	FPR1	NM_002029.3(FPR1):c.379G>A (p.Val127Ile)	SNV	Uncertain significance	652351	rs186613919	19:52249869-52249869	19:51746616-51746616
11	FPR1	NM_002029.3(FPR1):c.274C>A (p.Pro92Thr)	SNV	Uncertain significance	656419	rs750324912	19:52249974-52249974	19:51746721-51746721
12	FPR1	NM_002029.3(FPR1):c.205G>A (p.Val69Met)	SNV	Uncertain significance	660114	rs199534146	19:52250043-52250043	19:51746790-51746790
13	FPR1	NM_002029.3(FPR1):c.198C>A (p.Asn66Lys)	SNV	Uncertain significance	660315	rs371282377	19:52250050-52250050	19:51746797-51746797
14	FPR1	NM_002029.3(FPR1):c.542C>T (p.Ser181Leu)	SNV	Uncertain significance	660454	rs146075164	19:52249706-52249706	19:51746453-51746453
15	CTSK	NM_000396.4(CTSK):c.905G>A (p.Trp302Ter)	SNV	Uncertain significance	684727	rs1571122183	1:150769360-150769360	1:150796884-150796884
16	FPR1	NC_000019.10:g.(?_51745922)_(51759909_?)dup	Duplication	Uncertain significance	831452		19:52249175-52263162
17	FPR1	NM_002029.4(FPR1):c.898C>G (p.Leu300Val)	SNV	Uncertain significance	835264		19:52249350-52249350	19:51746097-51746097
18	FPR1	NM_002029.4(FPR1):c.736G>T (p.Val246Phe)	SNV	Uncertain significance	836559		19:52249512-52249512	19:51746259-51746259
19	FPR1	NM_002029.4(FPR1):c.40G>A (p.Gly14Arg)	SNV	Uncertain significance	838179		19:52250208-52250208	19:51746955-51746955
20	FPR1	NM_002029.4(FPR1):c.952G>A (p.Ala318Thr)	SNV	Uncertain significance	840695		19:52249296-52249296	19:51746043-51746043
21	FPR1	NM_002029.4(FPR1):c.440T>C (p.Ile147Thr)	SNV	Uncertain significance	841167		19:52249808-52249808	19:51746555-51746555
22	FPR1	NM_002029.4(FPR1):c.79A>G (p.Ile27Val)	SNV	Uncertain significance	841693		19:52250169-52250169	19:51746916-51746916
23	FPR1	NM_002029.4(FPR1):c.713G>A (p.Arg238His)	SNV	Uncertain significance	844349		19:52249535-52249535	19:51746282-51746282
24	FPR1	NM_002029.4(FPR1):c.955A>C (p.Ser319Arg)	SNV	Uncertain significance	847520		19:52249293-52249293	19:51746040-51746040
25	FPR1	NM_002029.4(FPR1):c.934C>T (p.Leu312=)	SNV	Uncertain significance	848388		19:52249314-52249314	19:51746061-51746061
26	FPR1	NM_002029.4(FPR1):c.613C>T (p.Arg205Trp)	SNV	Uncertain significance	851750		19:52249635-52249635	19:51746382-51746382
27	FPR1	NM_002029.4(FPR1):c.826T>C (p.Tyr276His)	SNV	Uncertain significance	852538		19:52249422-52249422	19:51746169-51746169
28	FPR1	NM_002029.4(FPR1):c.570G>C (p.Arg190Ser)	SNV	Uncertain significance	856172		19:52249678-52249678	19:51746425-51746425
29	FPR1	NM_002029.4(FPR1):c.331G>A (p.Gly111Arg)	SNV	Uncertain significance	860414		19:52249917-52249917	19:51746664-51746664
30	FPR1	NM_002029.4(FPR1):c.654T>A (p.Ala218=)	SNV	Uncertain significance	937938		19:52249594-52249594	19:51746341-51746341
31	FPR1	NM_002029.4(FPR1):c.721C>T (p.Arg241Trp)	SNV	Uncertain significance	938975		19:52249527-52249527	19:51746274-51746274
32	FPR1	NM_002029.4(FPR1):c.596C>T (p.Thr199Met)	SNV	Uncertain significance	946253		19:52249652-52249652	19:51746399-51746399
33	FPR1	NM_002029.4(FPR1):c.722G>A (p.Arg241Gln)	SNV	Uncertain significance	950010		19:52249526-52249526	19:51746273-51746273
34	FPR1	NM_002029.4(FPR1):c.664G>A (p.Gly222Arg)	SNV	Uncertain significance	951604		19:52249584-52249584	19:51746331-51746331
35	FPR1	NM_002029.4(FPR1):c.823A>G (p.Met275Val)	SNV	Uncertain significance	952169		19:52249425-52249425	19:51746172-51746172
36	FPR1	NM_002029.4(FPR1):c.751T>C (p.Phe251Leu)	SNV	Uncertain significance	956161		19:52249497-52249497	19:51746244-51746244
37	FPR1	NM_002029.4(FPR1):c.943G>A (p.Ala315Thr)	SNV	Uncertain significance	958537		19:52249305-52249305	19:51746052-51746052
38	FPR1	NM_002029.4(FPR1):c.919G>A (p.Asp307Asn)	SNV	Uncertain significance	960581		19:52249329-52249329	19:51746076-51746076
39	FPR1	NM_002029.4(FPR1):c.634G>A (p.Ala212Thr)	SNV	Uncertain significance	963210		19:52249614-52249614	19:51746361-51746361
40	FPR1	NM_002029.4(FPR1):c.160C>T (p.Arg54Trp)	SNV	Uncertain significance	965936		19:52250088-52250088	19:51746835-51746835
41	FPR1	NM_002029.4(FPR1):c.497C>T (p.Thr166Ile)	SNV	Uncertain significance	966326		19:52249751-52249751	19:51746498-51746498
42	FPR1	NM_002029.3(FPR1):c.744A>C (p.Ala248=)	SNV	Likely benign	716687	rs145578657	19:52249504-52249504	19:51746251-51746251
43	FPR1	NM_002029.3(FPR1):c.582C>T (p.Ala194=)	SNV	Likely benign	726546	rs747540806	19:52249666-52249666	19:51746413-51746413
44	FPR1	NM_002029.3(FPR1):c.607A>G (p.Ile203Val)	SNV	Likely benign	783851	rs150239733	19:52249641-52249641	19:51746388-51746388
45	FPR1	NM_002029.3(FPR1):c.368G>A (p.Arg123His)	SNV	Likely benign	785829	rs149931707	19:52249880-52249880	19:51746627-51746627
46	FPR1	NM_002029.3(FPR1):c.26C>T (p.Thr9Met)	SNV	Likely benign	456364	rs148095693	19:52250222-52250222	19:51746969-51746969
47	FPR1	NM_002029.3(FPR1):c.488G>A (p.Arg163His)	SNV	Benign	456367	rs111768566	19:52249760-52249760	19:51746507-51746507
48	FPR1	NM_002029.3(FPR1):c.822C>T (p.Gly274=)	SNV	Benign	712949	rs547725110	19:52249426-52249426	19:51746173-51746173
49	FPR1	NM_002029.3(FPR1):c.117C>T (p.Leu39=)	SNV	Benign	526510	rs149382837	19:52250131-52250131	19:51746878-51746878
50	FPR1	NM_002029.3(FPR1):c.806G>A (p.Arg269His)	SNV	Benign	526511	rs142210016	19:52249442-52249442	19:51746189-51746189

Sources

Expression for Periodontitis

Search GEO for disease gene expression data for Periodontitis.

Sources

Pathways for Periodontitis

Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.02	TNFSF11 TNF TLR4 TLR2 SIGLEC5 MMP9
2	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.5	TNFSF11 TNF TLR4 TLR2 IL6 IL1B
3	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.45	TNFSF11 TNF MMP9 MMP1 IL6 IL1B
4	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.35	TNFSF11 TNF IL6 IL1B IL1A IL10
5	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.15	TNF TLR4 TLR2 MMP9 IL6 IL1B
6	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	13	TNF TLR4 TLR2 IL6 IL1B CXCL8
7	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.93	TNF IL6 IL1B IL1A IL10 CXCL8
8	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.93	TNF TLR4 TLR2 IL6 IL1B IL1A
9	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²³ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²³ NOD-like Receptor Signaling Pathways ⁶⁴	12.84	TNF TLR4 TLR2 IL6 IL1B IL1A
10	Salmonella infection (KEGG) ³⁶ Show member pathways Salmonella infection ³⁶	12.83	TNF TLR4 TLR2 IL6 IL1B CXCL8
11	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.8	TNF TLR4 TLR2 IL6 IL1B IL1A
12	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.71	TNF TLR4 TLR2 IL6 IL1B IL1A
13	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.7	TNF TLR4 TLR2 IL6 IL1B IL1A
14	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.69	TNFSF11 TNF TLR4 TLR2 IL1B IL1A
15	NF-kappaB Signaling ⁴	12.64	TNFSF11 TNF TLR2 IL1B IL10
16	Shigellosis ³⁶	12.44	TNF TLR4 IL1B CXCL8
17	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²³ iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.44	TNF TLR4 IL6 IL1B IL1A CXCL8
18	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.43	TNF TLR2 MMP9 MMP1 IL6 IL1B
19	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.39	TNF TLR4 TLR2 IL6 IL1A CXCL8
20	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.39	TNF TLR4 TLR2 IL1B IL1A IL10
21	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.38	TNF IL6 IL10 CXCL8
22	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.38	TNF IL6 IL1B CRP
23	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.37	TNF IL6 IL1B IL1A IL10 CXCL8
24	Proteoglycans in cancer ³⁶	12.35	TNF TLR4 TLR2 MMP9
25	NOD-like receptor signaling pathway ³⁶	12.35	TNF TLR4 IL6 IL1B CXCL8
26	Tuberculosis ³⁶	12.34	TNF TLR4 TLR2 IL6 IL1B IL1A
27	Colorectal Cancer Metastasis ⁶³	12.31	TNF TLR4 TLR2 MMP9 MMP1 IL6
28	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.31	TNF TLR4 TLR2 IL6 IL1B CXCL8
29	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.29	TNF IL6 IL1B

Periodontitis

Aliases & Classifications for Periodontitis

MalaCards integrated aliases for Periodontitis:

Classifications:

External Ids:

Summaries for Periodontitis

Related Diseases for Periodontitis

Diseases in the Periodontitis family:

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Periodontitis:

Symptoms & Phenotypes for Periodontitis

UMLS symptoms related to Periodontitis:

MGI Mouse Phenotypes related to Periodontitis:

Drugs & Therapeutics for Periodontitis

Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 51 :

Cochrane evidence based reviews: periodontitis

Genetic Tests for Periodontitis

Genetic tests related to Periodontitis:

Anatomical Context for Periodontitis

MalaCards organs/tissues related to Periodontitis:

Publications for Periodontitis

Articles related to Periodontitis:

Genes for Periodontitis

Genes related to Periodontitis (0 elite genes):

Variations for Periodontitis

ClinVar genetic disease variations for Periodontitis:

Expression for Periodontitis

Pathways for Periodontitis

Pathways related to Periodontitis according to GeneCards Suite gene sharing:

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵¹ :