Periodontitis, Chronic

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Aliases & Classifications for Periodontitis, Chronic

MalaCards integrated aliases for Periodontitis, Chronic:

Name: Periodontitis, Chronic 57
Chronic Periodontitis 53 16 71 75 31
Periodontitis, Adult 57



Autosomal recessive 57


External Ids:

OMIM® 57 260950
ICD10 31 K05.3
MedGen 40 C0266929
UMLS 71 C0266929

Summaries for Periodontitis, Chronic

OMIM®: 57 Chronic periodontitis, formerly called adult periodontitis, is the most frequently occurring form of periodontitis and is characterized by slowly progressing alveolar bone destruction and attachment loss. Although chronic periodontitis is most prevalent in adults and has a slow progression, it can occur in children and adolescents and may have periods of rapid progression (Armitage, 1999). (260950) (Updated 08-Dec-2022)

MalaCards based summary: Periodontitis, Chronic, also known as chronic periodontitis, is related to gingival recession and acute pericementitis. An important gene associated with Periodontitis, Chronic is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Metronidazole and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and bone marrow, and related phenotype is neoplasm.

Wikipedia: 75 Chronic periodontitis is one of the seven categories of periodontitis as defined by the American Academy... more...

Related Diseases for Periodontitis, Chronic

Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis, Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 500)
# Related Disease Score Top Affiliating Genes
1 gingival recession 30.4 TNFSF11 MMP8 IL6 IL1B
2 acute pericementitis 30.2 TNFSF11 MMP8 IL6 IL1B
3 inflammatory bowel disease 1 29.9 IL6 IL1B
4 gingival overgrowth 29.9 MMP8 MMP1 IL6
5 necrotizing ulcerative gingivitis 29.9 IL6 IL1B
6 suppurative periapical periodontitis 29.8 IL6 IL1B
7 vaginitis 29.8 IL6 IL1B
8 complex regional pain syndrome 29.8 IL6 IL1B
9 bronchiectasis 29.8 MMP8 IL6 IL1B
10 chronic kidney disease 29.8 TNFSF11 TNFRSF11B IL6 IL1B
11 gastroesophageal reflux 29.8 IL6 IL1B DPP7
12 spondylitis 29.7 TNFSF11 IL6 IL1B
13 periodontitis, aggressive, 1 29.7 MMP8 MMP1
14 dry eye syndrome 29.7 IL6 IL1B
15 pulmonary disease, chronic obstructive 29.7 MMP8 MMP1 IL6 IL1B
16 pain agnosia 29.6 IL6 IL1B
17 lung disease 29.6 MMP8 IL6 IL1B
18 kidney disease 29.6 TNFSF11 TNFRSF11B IL6 IL1B
19 periapical periodontitis 29.5 TNFSF11 MMP8 IL6 IL1B
20 immune deficiency disease 29.5 TNFSF11 MMP8 IL6 IL1B
21 peptic ulcer disease 29.5 IL6 IL1B
22 arthritis 29.5 TNFSF11 MMP8 MMP1 IL6 IL1B
23 chronic apical periodontitis 29.4 TNFSF11 MMP8 IL6 IL1B
24 root resorption 29.4 TNFSF11 TNFRSF11B IL6 IL1B
25 spondyloarthropathy 1 29.4 TNFSF11 TNFRSF11B IL6 IL1B
26 bone disease 29.3 TNFSF11 TNFRSF11B IL6
27 pulpitis 29.2 MMP1 IL6 IL1B
28 type 1 diabetes mellitus 29.2 TNFSF11 TNFRSF11B IL6 IL1B
29 osteomyelitis 29.2 TNFSF11 MMP1 IL6 IL1B
30 rheumatoid arthritis 29.1 TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B
31 gingivitis 28.9 MMP8 MMP1 IL6 IL1B
32 cerebral palsy 28.9 MMP8 MMP1 IL6 IL1B
33 periodontitis 28.9 TNFSF11 MMP8 MMP1 IL6 IL1B
34 aggressive periodontitis 28.8 TNFSF11 MMP8 MMP1 IL6 IL1B
35 arthropathy 28.6 TNFSF11 TNFRSF11B MMP1 IL6 IL1B
36 gingival disease 28.6 TNFSF11 MMP8 MMP1 IL6 IL1B
37 osteoporosis 28.5 TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B
38 psoriatic arthritis 28.4 TNFSF11 TNFRSF11B MMP1 IL6 IL1B
39 osteoarthritis 28.4 TNFSF11 TNFRSF11B MMP1 IL6 IL1B
40 type 2 diabetes mellitus 10.8
41 diabetes mellitus 10.7
42 oto-palatal-digital syndrome 10.6
43 rickets 10.5
44 cytokine deficiency 10.5
45 coronary heart disease 1 10.4
46 rapidly involuting congenital hemangioma 10.4
47 leptin deficiency or dysfunction 10.4
48 active peptic ulcer disease 10.4
49 hair whorl 10.4
50 tobacco addiction 10.4

Comorbidity relations with Periodontitis, Chronic via Phenotypic Disease Network (PDN):

Acute Cystitis Dental Caries
Heart Disease

Graphical network of the top 20 diseases related to Periodontitis, Chronic:

Diseases related to Periodontitis, Chronic

Symptoms & Phenotypes for Periodontitis, Chronic

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
gingival inflammation

alveolar bone destruction

adolescent onset

Clinical features from OMIM®:

260950 (Updated 08-Dec-2022)

MGI Mouse Phenotypes related to Periodontitis, Chronic:

# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 IL1B IL6 MMP1 MMP8 TNFSF11

Drugs & Therapeutics for Periodontitis, Chronic

Drugs for Periodontitis, Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 235)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Metronidazole Approved Phase 4 443-48-1, 69198-10-3 4173
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1, 93107-08-5 2764
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
Ethinylestradiol Approved Phase 4 57-63-6 5991
Polyestradiol phosphate Approved Phase 4 28014-46-2
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
Moxifloxacin Approved, Investigational Phase 4 186826-86-8, 354812-41-2, 151096-09-2 152946
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Minocycline Approved, Investigational Phase 4 10118-90-8, 13614-98-7 54675783 5281021
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 4 55-56-1 2713 9552079
Simvastatin Approved Phase 4 79902-63-9 54454
Lycopene Approved, Investigational Phase 4 502-65-8 446925
Licorice Approved Phase 4
Ethanol Approved Phase 4 64-17-5 702
Montelukast Approved Phase 4 158966-92-8 5281040
Turmeric Approved, Experimental, Investigational Phase 4
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
Metamfetamine Approved, Illicit, Withdrawn Phase 4 537-46-2 10836
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
Zoledronic acid Approved Phase 4 118072-93-8 68740
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
Phenothiazine Experimental, Vet_approved Phase 4 92-84-2 7108
26 Immunologic Factors Phase 4
27 Anti-Bacterial Agents Phase 4
28 Anti-Infective Agents Phase 4
29 Antiprotozoal Agents Phase 4
30 Antiparasitic Agents Phase 4
31 Adjuvants, Immunologic Phase 4
32 Viscosupplements Phase 4
33 Protective Agents Phase 4
34 Aloe Phase 4
35 Hormones Phase 4
36 Estradiol 3-benzoate Phase 4
37 Estradiol 17 beta-cypionate Phase 4
38 Contraceptives, Oral, Combined Phase 4
39 Contraceptives, Oral Phase 4
40 Contraceptive Agents Phase 4
41 Cytochrome P-450 Enzyme Inhibitors Phase 4
42 Norgestimate, ethinyl estradiol drug combination Phase 4
43 Antioxidants Phase 4
44 Superoxide Dismutase Phase 4
45 Anti-Infective Agents, Local Phase 4
46 Chlorhexidine gluconate Phase 4
Rosuvastatin Calcium Phase 4 147098-20-2
48 Antimetabolites Phase 4
49 Hypolipidemic Agents Phase 4
50 Anticholesteremic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 363)
# Name Status NCT ID Phase Drugs
1 Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial Unknown status NCT02735395 Phase 4 Metronidazole 250 (7 days);Metronidazole 400 (7 days);Metronidazole 250 (14 days);Metronidazole 400 (14 days);Amoxicillin
2 Effect of Probiotic Lactobacillus Reuteri-containing Lozenges (Prodentis) on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
3 Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis Unknown status NCT00297531 Phase 4
4 Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone Unknown status NCT00296881 Phase 4
5 Evaluating the Adjunctive Effect of Stress Reduction Protocol in the Non-Surgical Periodontal Therapy of Chronic Periodontitis Subjects Associated With Stress: A Randomized Control Pilot Study Unknown status NCT02487862 Phase 4
6 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
7 Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% (Hyadent BG®) and Enamel Matrix Derivative (Emdogain®) in Periodontal Regeneration: A Randomized Clinical Trial Unknown status NCT04274244 Phase 4 Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML;Enamel Matrix Proteins (Active comparator group)
8 Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection: Randomized Clinical Trial. Unknown status NCT03863249 Phase 4 ADJUNTIVE ANTIBIOTICS
9 Preparation and Analysis of Material, Biological and Clinical Parameters of Metronidazole-loaded Porous Matrices for Local Periodontitis Treatment Unknown status NCT03791099 Phase 4 Metronidazole
10 Filling of Periodontal Pockets With a Commercially Available Injectable Cross-linked Hyaluronic Acid Dental Filler Versus Oral Hygiene Alone, After Scaling and Root Planing and Chlorhexidine Disinfection, for the Treatment of Periodontitis: A Single-blinded, Multi Center, Prospective, Randomized Controlled Trial Unknown status NCT02391974 Phase 4
11 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
12 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole as Adjunctive Therapy to Mechanical Treatment of Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
13 Clinical and Microbiological Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers. Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
14 Long-term Safety Evaluation of Minocycline Resistance After Treatment With Minocycline HCl Microspheres, 1 mg in Subjects With Chronic Periodontitis Completed NCT00668746 Phase 4 Minocycline HCl microspheres
15 Propolis Improves Periodontal Status and Glycemic Control in Subjects With Type 2 Diabetes Mellitus and Chronic Periodontitis: a Randomized Clinical Trial Completed NCT02794506 Phase 4 Propolis;Placebo
16 Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase Completed NCT04675385 Phase 4 0.2% hyaluronic acid gel
17 Effect of Scaling & Root Planing (SRP) Combined With Therapy Of Omega-3 Fatty Acid on Clinical Parameters and Serum Levels of C-Reactive Protein (CRP) in Chronic Periodontitis - A Randomised Control Trial. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
19 Systemic Lycopene as an Adjunct to Scaling and Rootplaning in Chronic Periodontitis Patients With Type 2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
20 Clinical and Laboratory Effect of 0.8% Hyaluronic Acid Gel in Conventional Treatment of Moderate to Severe Chronic Periodontitis Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
21 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis: Randomized Clinical Trial Completed NCT03025204 Phase 4
22 Efficacy of Complex Phytoadaptogenes as an Adjunct to Non-surgical Periodontal Treatment in Patients With Chronic Periodontitis: a Randomized Clinical Trial Completed NCT04623164 Phase 4 Cocktail from complex phytoadaptogens (CFA)
23 Clinical and Microbiological of Antimicrobial Photodynamic Therapy on Surgical Treatment of Chronic Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial. Completed NCT02734784 Phase 4
24 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
25 The Effect Of SRP With Adjunctive Systemic Therapy Of Leukotriene Receptor Antagonist-Montelukast On The Serum C Reactive Protein Levels & Clinical Parameters In Chronic Periodontitis Patients - A Randomized Controlled Trial Completed NCT02014532 Phase 4 Montelukast;Placebo
26 The Use of Simvastatin Gel With Perforated Resorbable Membranes in the Treatment of Intrabony Defects in Chronic Periodontitis Patients (Clinical and Biochemical Study) Completed NCT03419429 Phase 4 Simvastatin
27 The Response of Periodontal Pathogens to the Respective or Combined Treatment of Scaling and Root Planning and Locally Delivered Minocycline in Patients With Chronic Periodontitis- a Short-term Randomized Clinical Trial Completed NCT02355977 Phase 4 minocycline
28 Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial. Completed NCT03368430 Phase 4 Placebo
29 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
30 Efficacy of Adjunctive Photodynamic Therapy in Non-surgical Treatment of Chronic Periodontitis: a Randomized , Controlled Clinical Trial Completed NCT01034501 Phase 4
31 A Multicenter, Randomized, Examiner Blinded Study of Photoactivated Disinfection With Scaling and Root Planing in the Treatment of Chronic Periodontitis Completed NCT00297518 Phase 4
32 Local Drug Delivery of Aloe Vera Gel in Chronic Periodontitis Patients With Controlled Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
33 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
34 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
35 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling in Patients With Advanced Chronic Periodontitis Completed NCT03498404 Phase 4
36 Clinically Evaluating the Effects of Topical Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis Completed NCT04964167 Phase 4
37 The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial) Completed NCT03783845 Phase 4
38 Regenerative Potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) Bone Graft in the Treatment of Intrabony Defects; A Comparative Clinico Radiographic Study. Completed NCT04767243 Phase 4 open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
39 Effects of Photodynamic Therapy on Clinical and Immunological Parameters in a Group of Periodontal Patients Undergoing Supportive Periodontal Therapy Completed NCT02666573 Phase 4
40 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin: a Clinical Trial Completed NCT02641210 Phase 4 Albendazole
41 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)
42 Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study Completed NCT02808988 Phase 4
43 "Efficacy of Nonsurgical Periodontal Therapy in Patients With Chronic Renal Disease and Periodontitis: A Biochemical and Microbiological Assay" Completed NCT02901743 Phase 4
44 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
45 Evaluation of Gingival Crevicular Fluid Transforming Growth Factor-β1 Level After Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft Completed NCT02218515 Phase 4
46 Comparative Evaluation of Treatment Of Infrabony Defects With and Without 1.2% Rosuvastatin Gel: In-Vivo Study Completed NCT03677297 Phase 4 Rosuvastatin
47 Efficacy of Locally Delivered Minocycline in Advanced Periodontitis. A Clinico-microbiological Study Completed NCT04076098 Phase 4 Minocycline Hydrochloride
48 Custom Tray Application of Peroxide Gel as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis: A 6-Month Randomized Trial Completed NCT03262701 Phase 4 Hydrogen Peroxide Gel, 13 weeks;Hydrogen Peroxide Gel, 26 weeks
49 Biochemical Efficacy of Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in the Treatment of Stage II Periodontitis: A Randomized Controlled Clinical Trial Completed NCT05241509 Phase 4 Cymbopogon citratus (lemongrass) oil gel
50 Efficacy of Adjunctive Photodynamic Therapy Using Light-emitting Diode in the Treatment of Chronic Periodontitis Unknown status NCT01330082 Phase 2, Phase 3

Search NIH Clinical Center for Periodontitis, Chronic

Genetic Tests for Periodontitis, Chronic

Anatomical Context for Periodontitis, Chronic

Organs/tissues related to Periodontitis, Chronic:

MalaCards : Bone, Neutrophil, Bone Marrow, Heart, Kidney, Ovary, Liver

Publications for Periodontitis, Chronic

Articles related to Periodontitis, Chronic:

(show top 50) (show all 6209)
# Title Authors PMID Year
Evidence of a substantial genetic basis for risk of adult periodontitis. 57
11128917 2000
Self-reported periodontal disease in a Virginia twin population. 57
8106947 1993
Gingival crevicular fluid levels of oncostatin M in periodontal conditions. 53 62
20189410 2010
RANKL and OPG mRNA level after non-surgical periodontal treatment. 53 62
20033478 2010
Periodontitis, periodontopathic bacteria and lactoferrin. 53 62
20155438 2010
Serum levels of oncostatin M (a gp 130 cytokine): an inflammatory biomarker in periodontal disease. 53 62
20408777 2010
In vivo expression of Toll-like receptor 2, Toll-like receptor 4, CSF2 and LY64 in Chinese chronic periodontitis patients. 53 62
20233331 2010
Interleukin-6 (G-174C) and tumour necrosis factor-alpha (G-308A) gene polymorphisms in geriatric patients with chronic periodontitis. 53 62
19555357 2010
The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus. 53 62
20498757 2010
Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. 53 62
19602107 2010
Association of single nucleotide gene polymorphism at interleukin-1beta +3954, -511, and -31 in chronic periodontitis and aggressive periodontitis in Dravidian ethnicity. 53 62
20059418 2010
IL-1beta, TNF-alpha, total antioxidative status and microbiological findings in chronic periodontitis treated with fluorescence-controlled Er:YAG laser radiation. 53 62
20077495 2010
Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade. 53 62
19929954 2009
Genetic risk factors for periodontitis in a Japanese population. 53 62
19892918 2009
Alanine aminopeptidase and dipeptidyl peptidase IV in saliva of chronic periodontitis patients. 53 62
19905950 2009
Association among interleukin-6 gene polymorphism, diabetes and periodontitis in a Chinese population. 53 62
19549135 2009
Tumor necrosis factor-alpha -308G/A single nucleotide polymorphism and red-complex periodontopathogens are independently associated with increased levels of tumor necrosis factor-alpha in diseased periodontal tissues. 53 62
19076989 2009
Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. 53 62
19664151 2009
DNA methylation status of the IL8 gene promoter in oral cells of smokers and non-smokers with chronic periodontitis. 53 62
19659670 2009
Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in blood as markers for early atherosclerosis in subjects with chronic periodontitis. 53 62
18973519 2009
Interleukin-17, RANKL, and osteoprotegerin levels in gingival crevicular fluid from smoking and non-smoking patients with chronic periodontitis during initial periodontal treatment. 53 62
19656027 2009
Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes. 53 62
19712472 2009
Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease. 53 62
19576791 2009
Interleukin-10 (-592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. 53 62
19210338 2009
MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy. 53 62
19453573 2009
Salivary cytokine levels in subjects with chronic periodontitis and in periodontally healthy individuals: a cross-sectional study. 53 62
19210336 2009
Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. 53 62
19419438 2009
Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis. 53 62
20407653 2009
Microbiological composition associated with vitamin D receptor gene polymorphism in chronic periodontitis. 53 62
19684957 2009
TLR4 as a risk factor for periodontal disease: a reappraisal. 53 62
19426173 2009
The influence of chronic periodontitis on serum TNF-alpha, IL-6 and hs-CRP concentrations, and function of graft and survival of kidney transplant recipients. 53 62
19191811 2009
[The correlation between interleukin-1 receptor antagonist genotype and coronary heart disease in patients with chronic periodontitis]. 53 62
19290417 2009
Increased expression of extracellular matrix metalloproteinase inducer is associated with matrix metalloproteinase-1 and -2 in gingival tissues from patients with periodontitis. 53 62
19515022 2009
Assessment of aprotinin influence on periodontal clinical status and matrix metalloproteinases 1, 2 and their tissue inhibitors saliva concentrations in patients with chronic periodontitis. 53 62
19758971 2009
Analysis of the association between interleukin-1beta (+3954) gene polymorphism and chronic periodontitis in a sample of the south Indian population. 53 62
19336858 2009
TLR4 and IL-18 gene variants in chronic periodontitis: impact on disease susceptibility and severity. 53 62
19811440 2009
The impact of the IL-11:IL-17 ratio on the chronic periodontitis pathogenesis: a preliminary report. 53 62
18992017 2009
Increase of gingival matured dendritic cells number in elderly patients with chronic periodontitis. 53 62
18771763 2009
The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome. 53 62
18725394 2008
Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis. 53 62
18710412 2008
Saliva concentrations of RANKL and osteoprotegerin in smoker versus non-smoker chronic periodontitis patients. 53 62
18727653 2008
Lack of association between the TNF-alpha -308 (G/A) genetic polymorphism and periodontal disease in Brazilians. 53 62
19148387 2008
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. 53 62
18634923 2008
An interleukin-1beta (IL-1beta) single-nucleotide polymorphism at position 3954 and red complex periodontopathogens independently and additively modulate the levels of IL-1beta in diseased periodontal tissues. 53 62
18541658 2008
Formation of osteoclast-like cells from peripheral blood of periodontitis patients occurs without supplementation of macrophage colony-stimulating factor. 53 62
18435789 2008
[Relationship between interleukin-6 gene-572C/G polymorphism and chronic periodontitis]. 53 62
19031817 2008
Genetic markers of tumour necrosis factor alpha in aggressive and chronic periodontitis. 53 62
18363738 2008
Prevotella intermedia induces matrix metalloproteinase-9 expression in human periodontal ligament cells. 53 62
18400000 2008
The effect of periodontal treatment on IL-6 production of peripheral blood monocytes in aggressive periodontitis and chronic periodontitis patients. 53 62
18523355 2008
Interleukin-11, interleukin-1beta, interleukin-12 and the pathogenesis of inflammatory periodontal diseases. 53 62
18433382 2008

Variations for Periodontitis, Chronic

Expression for Periodontitis, Chronic

Search GEO for disease gene expression data for Periodontitis, Chronic.

Pathways for Periodontitis, Chronic

Pathways related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
3 11.64 MMP1 IL6 IL1B
4 11.48 TNFSF11 TNFRSF11B IL6
5 11.42 MMP1 IL6 IL1B
6 11.29 TNFSF11 IL6
7 11.27 IL6 IL1B
8 11.24 TNFSF11 IL6
Show member pathways
11.23 MMP1 IL6 IL1B
Show member pathways
11.22 TNFRSF11B IL1B
11 11.12 MMP1 IL6
12 11.12 TNFSF11 IL6 IL1B
13 11.11 IL6 IL1B
14 11.08 TNFSF11 TNFRSF11B
15 11.05 IL6 IL1B
16 11 IL6 IL1B
17 10.97 IL6 IL1B
18 10.83 IL6 IL1B
19 10.73 IL6 IL1B
20 10.61 MMP1 IL6 IL1B
21 10.58 TNFSF11 TNFRSF11B IL6 IL1B
22 10.56 IL6 IL1B

GO Terms for Periodontitis, Chronic

Cellular components related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.47 TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B

Biological processes related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.11 TNFSF11 MMP8 IL6 IL1B
2 extracellular matrix organization GO:0030198 10 TNFRSF11B MMP8 MMP1
3 cytokine-mediated signaling pathway GO:0019221 9.95 TNFSF11 IL6 IL1B
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNFSF11 IL6 IL1B
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 TNFSF11 IL6 IL1B
6 negative regulation of neurogenesis GO:0050768 9.84 IL6 IL1B
7 positive regulation of interleukin-6 production GO:0032755 9.8 MMP8 IL6 IL1B
8 positive regulation of glial cell proliferation GO:0060252 9.76 IL6 IL1B
9 negative regulation of bone resorption GO:0045779 9.73 IL6 TNFRSF11B
10 positive regulation of JNK cascade GO:0046330 9.73 TNFSF11 MMP8 IL1B
11 regulation of neuroinflammatory response GO:0150077 9.67 MMP8 IL6
12 vascular endothelial growth factor production GO:0010573 9.46 IL6 IL1B
13 regulation of microglial cell activation GO:1903978 9.26 MMP8 IL6
14 positive regulation of neuroinflammatory response GO:0150078 9.1 MMP8 IL6 IL1B

Molecular functions related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 TNFSF11 TNFRSF11B IL6 IL1B

Sources for Periodontitis, Chronic

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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