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MCID: PRD040
MIFTS: 52

Periodontitis, Chronic

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Periodontitis, Chronic

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MalaCards integrated aliases for Periodontitis, Chronic:

Name: Periodontitis, Chronic 57
Chronic Periodontitis 54 17 70 32
Periodontitis, Adult 57

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal recessive


HPO:

31
periodontitis, chronic:
Inheritance autosomal recessive inheritance
Onset and clinical course onset


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Blood diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

OMIM® 57 260950
ICD10 32 K05.3
MedGen 41 C0266929
UMLS 70 C0266929
Sources

Summaries for Periodontitis, Chronic

About this section
OMIM® : 57 Chronic periodontitis, formerly called adult periodontitis, is the most frequently occurring form of periodontitis and is characterized by slowly progressing alveolar bone destruction and attachment loss. Although chronic periodontitis is most prevalent in adults and has a slow progression, it can occur in children and adolescents and may have periods of rapid progression (Armitage, 1999). (260950) (Updated 20-May-2021)

MalaCards based summary : Periodontitis, Chronic, also known as chronic periodontitis, is related to gingival recession and bone resorption disease. An important gene associated with Periodontitis, Chronic is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Simvastatin and Turmeric have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are gingivitis and periodontitis

Wikipedia : 73 Chronic periodontitis is one of the seven categories of periodontitis as defined by the American Academy... more...

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Related Diseases for Periodontitis, Chronic

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Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis, Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)
# Related Disease Score Top Affiliating Genes
1 gingival recession 30.4 TNFSF11 MMP8 IL6 IL1B
2 bone resorption disease 30.2 TNFSF11 TNFRSF11B IL6 IL1B
3 diabetes mellitus 29.9 TNFSF11 MMP8 MMP1 IL6 IL1B
4 gingival overgrowth 29.9 MMP8 MMP1 IL6
5 suppurative periapical periodontitis 29.9 IL6 IL1B
6 chlamydia pneumonia 29.9 IL6 IL1B
7 pain agnosia 29.8 IL6 IL1B
8 osteomyelitis 29.7 TNFSF11 IL6 IL1B
9 spondylitis 29.7 TNFSF11 IL6 IL1B
10 leukemia, acute monocytic 29.7 IL6 IL1B
11 chronic apical periodontitis 29.6 TNFSF11 TNFRSF11B IL1B
12 spondyloarthropathy 1 29.6 TNFSF11 TNFRSF11B IL6
13 chronic kidney disease 29.5 TNFSF11 TNFRSF11B IL6 IL1B
14 pulmonary disease, chronic obstructive 29.5 MMP8 MMP1 IL6 IL1B
15 lung disease 29.5 MMP8 IL6 IL1B
16 type 2 diabetes mellitus 29.4 TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B
17 root resorption 29.3 TNFSF11 TNFRSF11B IL6 IL1B
18 arthritis 29.3 TNFSF11 MMP8 MMP1 IL6 IL1B
19 rheumatoid arthritis 29.0 TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B
20 bone disease 29.0 TNFSF11 TNFRSF11B IL6 IL1B
21 gingivitis 28.9 MMP8 MMP1 IL6 IL1B
22 cerebral palsy 28.9 MMP8 MMP1 IL6 IL1B
23 psoriatic arthritis 28.8 TNFSF11 MMP1 IL6 IL1B
24 periodontitis 28.7 TNFSF11 MMP8 MMP1 IL6 IL1B
25 osteoporosis 28.5 TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B
26 gingival disease 28.5 TNFSF11 MMP8 MMP1 IL6 IL1B
27 aggressive periodontitis 28.5 TNFSF11 MMP8 MMP1 IL6 IL1B
28 osteoarthritis 28.3 TNFSF11 TNFRSF11B MMP1 IL6 IL1B
29 cytokine deficiency 10.5
30 rapidly involuting congenital hemangioma 10.4
31 coronary heart disease 1 10.4
32 active peptic ulcer disease 10.4
33 disease by infectious agent 10.4
34 hair whorl 10.3
35 atherosclerosis susceptibility 10.3
36 impotence 10.3
37 heart disease 10.3
38 triiodothyronine receptor auxiliary protein 10.3
39 deficiency anemia 10.3
40 vascular disease 10.2
41 herpes simplex 10.2
42 proteasome-associated autoinflammatory syndrome 1 10.2
43 body mass index quantitative trait locus 11 10.2
44 body mass index quantitative trait locus 9 10.2
45 body mass index quantitative trait locus 8 10.2
46 body mass index quantitative trait locus 4 10.2
47 body mass index quantitative trait locus 10 10.2
48 body mass index quantitative trait locus 7 10.2
49 body mass index quantitative trait locus 12 10.2
50 body mass index quantitative trait locus 14 10.2

Comorbidity relations with Periodontitis, Chronic via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries
Heart Disease

Graphical network of the top 20 diseases related to Periodontitis, Chronic:



Diseases related to Periodontitis, Chronic
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Symptoms & Phenotypes for Periodontitis, Chronic

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Human phenotypes related to Periodontitis, Chronic:

31
# Description HPO Frequency HPO Source Accession
1 gingivitis 31 HP:0000230
2 periodontitis 31 HP:0000704

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Teeth:
periodontitis
periodontosis
gingival inflammation

Skull:
alveolar bone destruction

Misc:
adolescent onset

Clinical features from OMIM®:

260950 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Periodontitis, Chronic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 IL1B IL6 MMP1 MMP8 TNFSF11
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Drugs & Therapeutics for Periodontitis, Chronic

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Drugs for Periodontitis, Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 231)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Turmeric Approved, Experimental, Investigational Phase 4
3
Atorvastatin Approved Phase 4 134523-00-5 60823
4
Ethanol Approved Phase 4 64-17-5 702
5
Licorice Approved Phase 4
6
Zoledronic Acid Approved Phase 4 118072-93-8 68740
7
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
8
Polyestradiol phosphate Approved Phase 4 28014-46-2
9
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
10
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
11
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
12
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
13
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
14
Montelukast Approved Phase 4 158966-92-8 5281040
15
Lycopene Approved, Investigational Phase 4 502-65-8 446925
16
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
17
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
18
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
19
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
20
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
21
Edetic Acid Approved, Vet_approved Phase 4 60-00-4, 62-33-9 6049
22
Pentetic acid Approved Phase 4 67-43-6
23
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
24
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
25
Phenothiazine Experimental, Vet_approved Phase 4 92-84-2
26 Antioxidants Phase 4
27 Viscosupplements Phase 4
28 Adjuvants, Immunologic Phase 4
29 Protective Agents Phase 4
30 Immunologic Factors Phase 4
31 Omega 3 Fatty Acid Phase 4
32 Antibiotics, Antitubercular Phase 4
33 Anticholesteremic Agents Phase 4
34 Rosuvastatin Calcium Phase 4 147098-20-2
35 Antimetabolites Phase 4
36 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
37 Hypolipidemic Agents Phase 4
38 Lipid Regulating Agents Phase 4
39 Calcium, Dietary Phase 4
40 Fluorides Phase 4
41 Tolonium Chloride Phase 4
42 Turmeric extract Phase 4
43 Superoxide Dismutase Phase 4
44 Mitogens Phase 4
45 Aloe Phase 4
46 Photosensitizing Agents Phase 4
47 Diphosphonates Phase 4
48 Contraceptive Agents Phase 4
49 Contraceptives, Oral, Combined Phase 4
50 Estradiol 3-benzoate Phase 4

Interventional clinical trials:

(show top 50) (show all 342)
# Name Status NCT ID Phase Drugs
1 Effect of Probiotic Lactobacillus Reuteri-containing Lozenges (Prodentis) on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
2 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
3 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
4 Preparation and Analysis of Material, Biological and Clinical Parameters of Metronidazole-loaded Porous Matrices for Local Periodontitis Treatment Unknown status NCT03791099 Phase 4 Metronidazole
5 Filling of Periodontal Pockets With a Commercially Available Injectable Cross-linked Hyaluronic Acid Dental Filler Versus Oral Hygiene Alone, After Scaling and Root Planing and Chlorhexidine Disinfection, for the Treatment of Periodontitis: A Single-blinded, Multi Center, Prospective, Randomized Controlled Trial Unknown status NCT02391974 Phase 4
6 Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection: Randomized Clinical Trial. Unknown status NCT03863249 Phase 4 ADJUNTIVE ANTIBIOTICS
7 Evaluating the Adjunctive Effect of Stress Reduction Protocol in the Non-Surgical Periodontal Therapy of Chronic Periodontitis Subjects Associated With Stress: A Randomized Control Pilot Study Unknown status NCT02487862 Phase 4
8 Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone Unknown status NCT00296881 Phase 4
9 Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis Unknown status NCT00297531 Phase 4
10 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
11 "Comparative Evaluation Of The Efficacy Of Atorvastatin Gel As An Adjunct To Allografts In The Treatment Of Intrabony Defects" - A Clinico Radiological Study Completed NCT03009097 Phase 4 DFDBA with atorvastatin
12 Effect of Scaling & Root Planing (SRP) Combined With Therapy Of Omega-3 Fatty Acid on Clinical Parameters and Serum Levels of C-Reactive Protein (CRP) in Chronic Periodontitis - A Randomised Control Trial. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
13 Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase Completed NCT04675385 Phase 4 0.2% hyaluronic acid gel
14 Efficacy of Complex Phytoadaptogenes as an Adjunct to Non-surgical Periodontal Treatment in Patients With Chronic Periodontitis: a Randomized Clinical Trial Completed NCT04623164 Phase 4 Cocktail from complex phytoadaptogens (CFA)
15 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)
16 The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial) Completed NCT03783845 Phase 4
17 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling in Patients With Advanced Chronic Periodontitis Completed NCT03498404 Phase 4
18 Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study Completed NCT02808988 Phase 4
19 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole as Adjunctive Therapy to Mechanical Treatment of Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
20 Efficacy of Adjunctive Photodynamic Therapy in Non-surgical Treatment of Chronic Periodontitis: a Randomized , Controlled Clinical Trial Completed NCT01034501 Phase 4
21 The Use of Simvastatin Gel With Perforated Resorbable Membranes in the Treatment of Intrabony Defects in Chronic Periodontitis Patients (Clinical and Biochemical Study) Completed NCT03419429 Phase 4 Simvastatin
22 Clinical and Microbiological of Antimicrobial Photodynamic Therapy on Surgical Treatment of Chronic Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial. Completed NCT02734784 Phase 4
23 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin: a Clinical Trial Completed NCT02641210 Phase 4 Albendazole
24 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
25 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
26 The Response of Periodontal Pathogens to the Respective or Combined Treatment of Scaling and Root Planning and Locally Delivered Minocycline in Patients With Chronic Periodontitis- a Short-term Randomized Clinical Trial Completed NCT02355977 Phase 4 minocycline
27 The Effect Of SRP With Adjunctive Systemic Therapy Of Leukotriene Receptor Antagonist-Montelukast On The Serum C Reactive Protein Levels & Clinical Parameters In Chronic Periodontitis Patients - A Randomized Controlled Trial Completed NCT02014532 Phase 4 Montelukast;Placebo
28 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
29 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
30 EFFECT OF SRP WITH ADJUNCTIVE THERAPY OF HERBAL IMMUNOMODULATORS ON THE SERUM C REACTIVE PROTEIN (CRP) LEVELS & CLINICAL PARAMETERS IN CHRONIC PERIODONTITIS PATIENTS - A RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED, CLINICAL TRIAL. Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
31 Clinical and Microbiological Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers. Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
32 Long-term Safety Evaluation of Minocycline Resistance After Treatment With Minocycline HCl Microspheres, 1 mg in Subjects With Chronic Periodontitis Completed NCT00668746 Phase 4 Minocycline HCl microspheres
33 Propolis Improves Periodontal Status and Glycemic Control in Subjects With Type 2 Diabetes Mellitus and Chronic Periodontitis: a Randomized Clinical Trial Completed NCT02794506 Phase 4 Propolis;Placebo
34 Local Drug Delivery of Aloe Vera Gel in Chronic Periodontitis Patients With Controlled Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
35 Systemic Lycopene as an Adjunct to Scaling and Rootplaning in Chronic Periodontitis Patients With Type 2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
36 Clinical and Laboratory Effect of 0.8% Hyaluronic Acid Gel in Conventional Treatment of Moderate to Severe Chronic Periodontitis Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
37 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis: Randomized Clinical Trial Completed NCT03025204 Phase 4
38 A Multicenter, Randomized, Examiner Blinded Study of Photoactivated Disinfection With Scaling and Root Planing in the Treatment of Chronic Periodontitis Completed NCT00297518 Phase 4
39 Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial. Completed NCT03368430 Phase 4 Placebo
40 Effects of Photodynamic Therapy on Clinical and Immunological Parameters in a Group of Periodontal Patients Undergoing Supportive Periodontal Therapy Completed NCT02666573 Phase 4
41 Comparative Evaluation of Treatment Of Infrabony Defects With and Without 1.2% Rosuvastatin Gel: In-Vivo Study Completed NCT03677297 Phase 4 Rosuvastatin
42 Evaluation of Gingival Crevicular Fluid Transforming Growth Factor-β1 Level After Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft Completed NCT02218515 Phase 4
43 "Efficacy of Nonsurgical Periodontal Therapy in Patients With Chronic Renal Disease and Periodontitis: A Biochemical and Microbiological Assay" Completed NCT02901743 Phase 4
44 Custom Tray Application of Peroxide Gel as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis: A 6-Month Randomized Trial Recruiting NCT03262701 Phase 4 Hydrogen Peroxide Gel, 13 weeks;Hydrogen Peroxide Gel, 26 weeks
45 Efficacy of Locally Delivered Minocycline in Advanced Periodontitis. A Clinico-microbiological Study Recruiting NCT04076098 Phase 4 Minocycline Hydrochloride
46 Regenerative Potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) Bone Graft in the Treatment of Intrabony Defects; A Comparative Clinico Radiographic Study. Recruiting NCT04767243 Phase 4 open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
47 Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial Active, not recruiting NCT02735395 Phase 4 Metronidazole 250 (7 days);Metronidazole 400 (7 days);Metronidazole 250 (14 days);Metronidazole 400 (14 days);Amoxicillin
48 Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% (Hyadent BG®) and Enamel Matrix Derivative (Emdogain®) in Periodontal Regeneration: A Randomized Clinical Trial Not yet recruiting NCT04274244 Phase 4 Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML;Enamel Matrix Proteins (Active comparator group)
49 Efficacy of Adjunctive Photodynamic Therapy Using Light-emitting Diode in the Treatment of Chronic Periodontitis Unknown status NCT01330082 Phase 2, Phase 3
50 Control of Periodontal Infections Completed NCT01098448 Phase 3 local tetracycline;systemic metronidazole and amoxicillin;local antibiotics and systemic metronidazole and amoxicillin

Search NIH Clinical Center for Periodontitis, Chronic

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Genetic Tests for Periodontitis, Chronic

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Anatomical Context for Periodontitis, Chronic

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MalaCards organs/tissues related to Periodontitis, Chronic:

40
Bone, Neutrophil, Endothelial, Kidney, Ovary, T Cells, Brain
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Publications for Periodontitis, Chronic

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Articles related to Periodontitis, Chronic:

(show top 50) (show all 5771)
# Title Authors PMID Year
1
Evidence of a substantial genetic basis for risk of adult periodontitis. 57
11128917 2000
2
Self-reported periodontal disease in a Virginia twin population. 57
8106947 1993
3
Gingival crevicular fluid levels of oncostatin M in periodontal conditions. 61 54
20189410 2010
4
RANKL and OPG mRNA level after non-surgical periodontal treatment. 61 54
20033478 2010
5
Periodontitis, periodontopathic bacteria and lactoferrin. 61 54
20155438 2010
6
In vivo expression of Toll-like receptor 2, Toll-like receptor 4, CSF2 and LY64 in Chinese chronic periodontitis patients. 61 54
20233331 2010
7
Serum levels of oncostatin M (a gp 130 cytokine): an inflammatory biomarker in periodontal disease. 54 61
20408777 2010
8
Interleukin-6 (G-174C) and tumour necrosis factor-alpha (G-308A) gene polymorphisms in geriatric patients with chronic periodontitis. 54 61
19555357 2010
9
The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus. 54 61
20498757 2010
10
Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. 61 54
19602107 2010
11
IL-1beta, TNF-alpha, total antioxidative status and microbiological findings in chronic periodontitis treated with fluorescence-controlled Er:YAG laser radiation. 61 54
20077495 2010
12
Association of single nucleotide gene polymorphism at interleukin-1beta +3954, -511, and -31 in chronic periodontitis and aggressive periodontitis in Dravidian ethnicity. 54 61
20059418 2010
13
Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade. 54 61
19929954 2009
14
Genetic risk factors for periodontitis in a Japanese population. 61 54
19892918 2009
15
Alanine aminopeptidase and dipeptidyl peptidase IV in saliva of chronic periodontitis patients. 61 54
19905950 2009
16
Association among interleukin-6 gene polymorphism, diabetes and periodontitis in a Chinese population. 61 54
19549135 2009
17
Tumor necrosis factor-alpha -308G/A single nucleotide polymorphism and red-complex periodontopathogens are independently associated with increased levels of tumor necrosis factor-alpha in diseased periodontal tissues. 54 61
19076989 2009
18
DNA methylation status of the IL8 gene promoter in oral cells of smokers and non-smokers with chronic periodontitis. 54 61
19659670 2009
19
Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. 54 61
19664151 2009
20
Interleukin-17, RANKL, and osteoprotegerin levels in gingival crevicular fluid from smoking and non-smoking patients with chronic periodontitis during initial periodontal treatment. 54 61
19656027 2009
21
Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in blood as markers for early atherosclerosis in subjects with chronic periodontitis. 54 61
18973519 2009
22
Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes. 54 61
19712472 2009
23
Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease. 61 54
19576791 2009
24
MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy. 54 61
19453573 2009
25
Salivary cytokine levels in subjects with chronic periodontitis and in periodontally healthy individuals: a cross-sectional study. 61 54
19210336 2009
26
Interleukin-10 (-592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. 54 61
19210338 2009
27
Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis. 61 54
20407653 2009
28
Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. 61 54
19419438 2009
29
Microbiological composition associated with vitamin D receptor gene polymorphism in chronic periodontitis. 54 61
19684957 2009
30
TLR4 as a risk factor for periodontal disease: a reappraisal. 61 54
19426173 2009
31
The influence of chronic periodontitis on serum TNF-alpha, IL-6 and hs-CRP concentrations, and function of graft and survival of kidney transplant recipients. 61 54
19191811 2009
32
[The correlation between interleukin-1 receptor antagonist genotype and coronary heart disease in patients with chronic periodontitis]. 54 61
19290417 2009
33
Increased expression of extracellular matrix metalloproteinase inducer is associated with matrix metalloproteinase-1 and -2 in gingival tissues from patients with periodontitis. 61 54
19515022 2009
34
TLR4 and IL-18 gene variants in chronic periodontitis: impact on disease susceptibility and severity. 54 61
19811440 2009
35
Assessment of aprotinin influence on periodontal clinical status and matrix metalloproteinases 1, 2 and their tissue inhibitors saliva concentrations in patients with chronic periodontitis. 54 61
19758971 2009
36
Increase of gingival matured dendritic cells number in elderly patients with chronic periodontitis. 61 54
18771763 2009
37
Analysis of the association between interleukin-1beta (+3954) gene polymorphism and chronic periodontitis in a sample of the south Indian population. 61 54
19336858 2009
38
The impact of the IL-11:IL-17 ratio on the chronic periodontitis pathogenesis: a preliminary report. 61 54
18992017 2009
39
The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome. 54 61
18725394 2008
40
Saliva concentrations of RANKL and osteoprotegerin in smoker versus non-smoker chronic periodontitis patients. 61 54
18727653 2008
41
Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis. 54 61
18710412 2008
42
Lack of association between the TNF-alpha -308 (G/A) genetic polymorphism and periodontal disease in Brazilians. 61 54
19148387 2008
43
An interleukin-1beta (IL-1beta) single-nucleotide polymorphism at position 3954 and red complex periodontopathogens independently and additively modulate the levels of IL-1beta in diseased periodontal tissues. 61 54
18541658 2008
44
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. 54 61
18634923 2008
45
[Relationship between interleukin-6 gene-572C/G polymorphism and chronic periodontitis]. 61 54
19031817 2008
46
Formation of osteoclast-like cells from peripheral blood of periodontitis patients occurs without supplementation of macrophage colony-stimulating factor. 61 54
18435789 2008
47
Genetic markers of tumour necrosis factor alpha in aggressive and chronic periodontitis. 61 54
18363738 2008
48
The effect of periodontal treatment on IL-6 production of peripheral blood monocytes in aggressive periodontitis and chronic periodontitis patients. 54 61
18523355 2008
49
Prevotella intermedia induces matrix metalloproteinase-9 expression in human periodontal ligament cells. 61 54
18400000 2008
50
Interleukin-11, interleukin-1beta, interleukin-12 and the pathogenesis of inflammatory periodontal diseases. 54 61
18433382 2008
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Variations for Periodontitis, Chronic

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Expression for Periodontitis, Chronic

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Search GEO for disease gene expression data for Periodontitis, Chronic.
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Pathways for Periodontitis, Chronic

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Pathways related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.39 TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B
2
Cytokine Signaling in Immune system 65
Show member pathways
 12.91 TNFSF11 TNFRSF11B MMP1 IL6 IL1B
3
TRAF Pathway 63
Show member pathways
 12.28 TNFSF11 TNFRSF11B IL1B
4
IL-17 Family Signaling Pathways 64
Show member pathways
 11.99 MMP1 IL6 IL1B
5
Interleukin-4 and 13 signaling 65
11.55 MMP1 IL6 IL1B
6
Malaria 36
11.3 IL6 IL1B
7
Interleukin-10 signaling 65
11.29 IL6 IL1B
8
Hematopoietic Stem Cell Differentiation 1
11.27 IL6 IL1B
9
Differentiation Pathway 1
11.27 TNFSF11 IL6
10
Rheumatoid arthritis 36
11.23 TNFSF11 MMP1 IL6 IL1B
11
Monoamine Transport 1
Show member pathways
 11.2 TNFRSF11B IL1B
12
African trypanosomiasis 36
11.13 IL6 IL1B
13
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.13 MMP1 IL6 IL1B
14
IL-10 Pathway 63
11.09 IL6 IL1B
15
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.07 MMP1 IL6
16
Development and heterogeneity of the ILC family 1
11.03 IL6 IL1B
17
Antifolate resistance 36
11 IL6 IL1B
18
Cytokines and Inflammatory Response 1
10.96 IL6 IL1B
19
Osteoclast Signaling 1
10.66 TNFSF11 TNFRSF11B
20
Osteoblast Signaling 1
10.58 TNFSF11 TNFRSF11B
21
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
10.58 TNFSF11 TNFRSF11B IL6 IL1B
22
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.45 IL6 IL1B
Sources

GO Terms for Periodontitis, Chronic

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Cellular components related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 TNFSF11 TNFRSF11B MMP8 IL6 IL1B
2 extracellular matrix GO:0031012 9.33 TNFRSF11B MMP8 MMP1
3 extracellular region GO:0005576 9.17 TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B

Biological processes related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.76 TNFSF11 MMP8 IL6 IL1B
2 extracellular matrix organization GO:0030198 9.72 TNFRSF11B MMP8 MMP1
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 TNFSF11 IL6 IL1B
4 positive regulation of epithelial to mesenchymal transition GO:0010718 9.58 IL6 IL1B
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 MMP8 IL1B
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.58 TNFSF11 IL6 IL1B
7 monocyte chemotaxis GO:0002548 9.57 TNFSF11 IL6
8 collagen catabolic process GO:0030574 9.56 MMP8 MMP1
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.54 IL6 IL1B
10 negative regulation of neurogenesis GO:0050768 9.52 IL6 IL1B
11 positive regulation of glial cell proliferation GO:0060252 9.51 IL6 IL1B
12 positive regulation of interleukin-6 production GO:0032755 9.5 MMP8 IL6 IL1B
13 negative regulation of bone resorption GO:0045779 9.49 TNFRSF11B IL6
14 cytokine-mediated signaling pathway GO:0019221 9.46 TNFSF11 MMP1 IL6 IL1B
15 regulation of neuroinflammatory response GO:0150077 9.43 MMP8 IL6
16 positive regulation of JNK cascade GO:0046330 9.43 TNFSF11 MMP8 IL1B
17 vascular endothelial growth factor production GO:0010573 9.37 IL6 IL1B
18 regulation of microglial cell activation GO:1903978 8.96 MMP8 IL6
19 positive regulation of neuroinflammatory response GO:0150078 8.8 MMP8 IL6 IL1B

Molecular functions related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNFSF11 TNFRSF11B IL6 IL1B
Sources

Sources for Periodontitis, Chronic

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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