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MCID: PRD040
MIFTS: 59

Periodontitis, Chronic

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Periodontitis, Chronic

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MalaCards integrated aliases for Periodontitis, Chronic:

Name: Periodontitis, Chronic 57 29
Chronic Periodontitis 55 73
Periodontitis, Adult 57

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
periodontitis, chronic:
Inheritance autosomal recessive inheritance
Onset and clinical course onset


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

OMIM 57 260950
MedGen 42 C0266929
ICD10 33 K05.3
UMLS 73 C0266929
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Summaries for Periodontitis, Chronic

About this section
OMIM : 57 Chronic periodontitis, formerly called adult periodontitis, is the most frequently occurring form of periodontitis and is characterized by slowly progressing alveolar bone destruction and attachment loss. Although chronic periodontitis is most prevalent in adults and has a slow progression, it can occur in children and adolescents and may have periods of rapid progression (Armitage, 1999). (260950)

MalaCards based summary : Periodontitis, Chronic, also known as chronic periodontitis, is related to chronic apical periodontitis and periodontitis. An important gene associated with Periodontitis, Chronic is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs sodium fluoride and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and testes, and related phenotypes are gingivitis and periodontitis

Wikipedia : 76 Chronic periodontitis is a common disease of the oral cavity consisting of chronic inflammation of the... more...

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Related Diseases for Periodontitis, Chronic

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Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis, Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 chronic apical periodontitis 32.1 TNFRSF11B TNFSF11
2 periodontitis 30.9 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
3 aggressive periodontitis 29.8 IL1B IL6 MMP1 MMP8 TNFSF11
4 arthritis 29.8 IL1B IL6 MMP1 TNFSF11
5 root resorption 29.7 IL1B TNFRSF11B TNFSF11
6 pulmonary disease, chronic obstructive 29.5 IL6 MMP1 TLR2
7 osteoporosis 29.4 IL1B IL6 TNFRSF11B TNFSF11
8 cerebral palsy 29.3 IL1B IL6 MMP8
9 rheumatoid arthritis 29.2 IL1B IL6 MMP1 TLR2 TNFRSF11B TNFSF11
10 gingivitis 29.0 IL1B IL6 MMP8 TLR2
11 psoriatic arthritis 28.7 IL1B IL6 MMP1 TNFRSF11B TNFSF11
12 periapical periodontitis 28.5 IL1B IL6 MMP8 TLR2 TNFRSF11B TNFSF11
13 periodontal disease 28.1 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
14 necrotizing ulcerative gingivitis 11.4
15 periodontosis 11.1
16 diabetes mellitus 10.5
17 diabetes mellitus, noninsulin-dependent 10.4
18 periapical granuloma 10.2 MMP8 TNFSF11
19 erdheim-chester disease 10.2 IL1B TNFSF11
20 fungal keratitis 10.1 MMP8 TLR2
21 idiopathic hypercalciuria 10.1 IL1B TNFSF11
22 haemophilus influenzae 10.1 IL1B TLR2
23 congenital cytomegalovirus 10.1 IL1B TLR2
24 suppurative otitis media 10.1 IL1B TLR2
25 polyarticular onset juvenile idiopathic arthritis 10.1 TNFRSF11B TNFSF11
26 hemophilic arthropathy 10.1 TNFRSF11B TNFSF11
27 primary systemic mycosis 10.1 IL1B TLR2
28 multicentric reticulohistiocytosis 10.1 TNFRSF11B TNFSF11
29 kummell's disease 10.1 TNFRSF11B TNFSF11
30 paget disease of bone 5, juvenile-onset 10.1 TNFRSF11B TNFSF11
31 familial expansile osteolysis 10.1 TNFRSF11B TNFSF11
32 impotence 10.1
33 scrub typhus 10.1 IL1B TLR2
34 tendinopathy 10.1 MMP1 MMP8
35 extrapulmonary tuberculosis 10.1 IL1B TLR2
36 multicentric carpotarsal osteolysis syndrome 10.1 TNFRSF11B TNFSF11
37 tooth resorption 10.1 TNFRSF11B TNFSF11
38 chronic ulcer of skin 10.1 MMP1 MMP8
39 glucocorticoid-induced osteoporosis 10.1 TNFRSF11B TNFSF11
40 ischemic bone disease 10.1 TNFRSF11B TNFSF11
41 kashin-beck disease 10.1 IL1B MMP1
42 pelvic organ prolapse 10.1 MMP1 MMP8
43 corneal edema 10.1 IL1B MMP1
44 legionellosis 10.1 IL1B TLR2
45 keratitis, hereditary 10.1 IL1B TLR2
46 endosteal hyperostosis, autosomal dominant 10.1 TNFRSF11B TNFSF11
47 bone remodeling disease 10.1 TNFRSF11B TNFSF11
48 pulmonary emphysema 10.0 MMP1 MMP8
49 septic arthritis 10.0 MMP1 TLR2
50 recurrent corneal erosion 10.0 IL1B IL6

Comorbidity relations with Periodontitis, Chronic via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries
Heart Disease

Graphical network of the top 20 diseases related to Periodontitis, Chronic:



Diseases related to Periodontitis, Chronic
Sources

Symptoms & Phenotypes for Periodontitis, Chronic

About this section

Symptoms via clinical synopsis from OMIM:

57
Teeth:
periodontitis
periodontosis
gingival inflammation

Skull:
alveolar bone destruction

Misc:
adolescent onset


Clinical features from OMIM:

260950

Human phenotypes related to Periodontitis, Chronic:

32
# Description HPO Frequency HPO Source Accession
1 gingivitis 32 HP:0000230
2 periodontitis 32 HP:0000704

MGI Mouse Phenotypes related to Periodontitis, Chronic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
2 neoplasm MP:0002006 9.43 IL1B IL6 MMP1 MMP8 TLR2 TNFSF11
3 skeleton MP:0005390 9.02 IL1B IL6 TLR2 TNFRSF11B TNFSF11
Sources

Drugs & Therapeutics for Periodontitis, Chronic

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Drugs for Periodontitis, Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 252)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 3 7681-49-4
2
Racepinephrine Approved Phase 4,Phase 1,Phase 2,Not Applicable 329-65-7 838
3
Epinephrine Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 51-43-4 5816
4
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 2713 9552079
5
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Not Applicable 9004-61-9 53477741
6
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable 443-48-1 4173
7
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
8
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
9
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
10
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
11
Polyestradiol phosphate Approved Phase 4 28014-46-2
12
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
13
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
14 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
15
Montelukast Approved Phase 4 158966-92-8 5281040
16
Minocycline Approved, Investigational Phase 4,Phase 3 10118-90-8 5281021
17
Turmeric Approved, Experimental, Investigational Phase 4,Not Applicable
18
Edetic Acid Approved, Vet_approved Phase 4 62-33-9, 60-00-4 6049
19
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
20
Pentetic acid Approved Phase 4 67-43-6
21
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
22
Zoledronic acid Approved Phase 4 118072-93-8 68740
23 Lycopene Approved, Investigational Phase 4,Phase 1,Phase 2 502-65-8 446925
24
Alendronate Approved Phase 4,Phase 2,Phase 3 66376-36-1, 121268-17-5 2088
25
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
26
Coal tar Approved Phase 4,Not Applicable 8007-45-2
27
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
28
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 73-31-4 896
29 Pharmaceutical Solutions Phase 4,Phase 3,Not Applicable
30 Listerine Phase 4,Phase 3
31 Acidophilus Phase 4,Phase 3,Phase 2,Not Applicable
32 Photosensitizing Agents Phase 4,Phase 2,Phase 3,Not Applicable
33 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Epinephryl borate Phase 4,Phase 1,Phase 2,Not Applicable
35 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
37 Immunologic Factors Phase 4,Phase 2,Not Applicable
38 Adjuvants, Immunologic Phase 4,Phase 2,Not Applicable
39 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
40 Viscosupplements Phase 4,Phase 2,Not Applicable
41 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
44 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
45 Omega 3 Fatty Acid Phase 4,Phase 2,Not Applicable,Early Phase 1
46 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
47 Bee Products Phase 4,Not Applicable
48 Propolis Phase 4,Not Applicable
49 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Not Applicable
50 Dermatologic Agents Phase 4,Phase 2,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 364)
# Name Status NCT ID Phase Drugs
1 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
2 Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
3 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
4 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
5 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
6 Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets Unknown status NCT02391974 Phase 4
7 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
8 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
9 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
10 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
11 Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis Completed NCT02014532 Phase 4 Montelukast;Placebo
12 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed NCT02355977 Phase 4 minocycline
13 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
14 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
15 Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis Completed NCT03419429 Phase 4 Simvastatin
16 Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
17 Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
18 Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis Completed NCT01034501 Phase 4
19 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
20 Melatonin as an Adjunctive Therapy for Chronic Periodontitis. Completed NCT03368430 Phase 4 Placebo
21 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis Completed NCT02794506 Phase 4 Propolis;Placebo
22 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
23 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
24 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling Completed NCT03498404 Phase 4
25 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Completed NCT00297518 Phase 4
26 MTZ Plus AMX in the Treatment of Smokers and Non-smokers Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
27 Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease Completed NCT02901743 Phase 4
28 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
29 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin Completed NCT02641210 Phase 4 Albendazole
30 Moxifloxacin in Situ Gel to Treat Periodontal Pocket. Completed NCT02016157 Phase 4 Moxifloxacin
31 "Efficacy Of 1.2% Rosuvastatin Gel In The Management Of Infrabony Defects" Completed NCT03677297 Phase 4 Rosuvastatin
32 The Effects of Periodontal Therapy on Glycemic Control in Diabetic Patients Completed NCT03783845 Phase 4 amoxicillin and metronidazole
33 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
34 Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft Completed NCT02218515 Phase 4
35 Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis Completed NCT02808988 Phase 4
36 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)
37 A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
38 Atorvastatin as an Adjunct to DFDBA in Intrabony Defects Completed NCT03009097 Phase 4 DFDBA with atorvastatin
39 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
40 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
41 Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
42 Full-mouth and Partial-mouth Scaling and Root Planing in Type 2 Diabetic Subjects Completed NCT02062047 Phase 4 Chlorhexidine
43 Photodynamic Therapy During Supportive Periodontal Therapy Completed NCT02666573 Phase 4
44 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4 Sodium alendronate
45 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4 Doxicicline
46 Adjunctive Hydrogen Peroxide for Periodontal Therapy Recruiting NCT03262701 Phase 4 Hydrogen Peroxide Gel, 13 weeks;Hydrogen Peroxide Gel, 26 weeks
47 Treatment of Periodontitis in Obese Individuals Recruiting NCT03103204 Phase 4
48 Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis Active, not recruiting NCT02735395 Phase 4 Metronidazole 250 (7 days);Metronidazole 400 (7 days);Metronidazole 250 (14 days);Metronidazole 400 (14 days);Amoxicillin
49 Porous Metronidazole Loaded Matrix for Local Treatment of Periodontitis. Active, not recruiting NCT03791099 Phase 4 Metronidazole
50 Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg Not yet recruiting NCT03762915 Phase 4 minocycline HCl microspheres

Search NIH Clinical Center for Periodontitis, Chronic

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Genetic Tests for Periodontitis, Chronic

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Genetic tests related to Periodontitis, Chronic:

# Genetic test Affiliating Genes
1 Periodontitis, Chronic 29
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Anatomical Context for Periodontitis, Chronic

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MalaCards organs/tissues related to Periodontitis, Chronic:

41
Bone, Endothelial, Testes, Ovary, Neutrophil, Kidney, Heart
Sources

Publications for Periodontitis, Chronic

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Articles related to Periodontitis, Chronic:

(show top 50) (show all 663)
# Title Authors Year
1
Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis. ( 30384155 )
2019
2
Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: Results obtained from a meta-analysis. ( 30388570 )
2019
3
Effect of non-surgical periodontal therapy on salivary metabolic fingerprint of generalized chronic periodontitis using nuclear magnetic resonance spectroscopy. ( 30396039 )
2019
4
The effect of periodontal therapy on neopterin and vascular cell adhesion molecule-1 levels in chronic periodontitis patients with and without acute myocardial infarction: a case-control study. ( 29641752 )
2018
5
Aggressive periodontitis presents a higher degree of bilateral symmetry in comparison with chronic periodontitis. ( 29576581 )
2018
6
Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis. ( 29576773 )
2018
7
Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis. ( 30303256 )
2018
8
Serum, salivary, and tissue levels of plasminogen in familial Mediterranean fever, amyloidosis, and chronic periodontitis. ( 29520774 )
2018
9
Quantitative gingival crevicular fluid proteome in type 2 diabetes mellitus and chronic periodontitis. ( 30362201 )
2018
10
The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled trial. ( 30328031 )
2018
11
Differences in the subgingival microbial population of chronic periodontitis in subjects with and without type 2 diabetes mellitus-a systematic review. ( 30306333 )
2018
12
Absence of cytomegalovirus in gingivitis and chronic periodontitis in HIV-1 patients in Northern Brazil. ( 30517535 )
2018
13
Shared genetic and epigenetic mechanisms between chronic periodontitis and oral squamous cell carcinoma. ( 30409304 )
2018
14
Is dietary melatonin supplementation a viable adjunctive therapy for chronic periodontitis?-A randomized controlled clinical trial. ( 30298556 )
2018
15
IFN-γR2 is strongly expressed on endothelial cells of gingival tissues from patients with chronic periodontitis. ( 30304122 )
2018
16
Detection of antibodies against Aggregatibacter actinomycetemcomitans in serum and saliva through ELISA in periodontally healthy individuals and individuals with chronic periodontitis. ( 30312650 )
2018
17
Polymorphisms of the vitamin D receptor gene (FOKI, CDX2, and GATA) and susceptibility to chronic periodontitis in diabetic and non-diabetic individuals: A case-control study. ( 30338675 )
2018
18
Chronic periodontitis impairs polymorphonuclear leucocyte-endothelium cell interactions and oxidative stress in humans. ( 30362144 )
2018
19
Dietary therapy and non-surgical periodontal treatment in obese patients with chronic periodontitis. ( 30362611 )
2018
20
Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis. ( 30364037 )
2018
21
Differential expression of periostin, sclerostin, receptor activator of nuclear factor-κB, and receptor activator of nuclear factor-κB ligand genes in severe chronic periodontitis. ( 30375186 )
2018
22
The effects of smoking on the expression of gelatinases in chronic periodontitis: a cross-sectional study. ( 30379214 )
2018
23
Multiple sessions of antimicrobial photodynamic therapy associated with surgical periodontal treatment in patients with chronic periodontitis. ( 30383298 )
2018
24
Twenty years later: Oral health-related quality of life and standard of treatment in patients with chronic periodontitis. ( 30383303 )
2018
25
Comparative evaluation of cathepsin K levels in gingival crevicular fluid among smoking and nonsmoking patients with chronic periodontitis. ( 30409937 )
2018
26
Influence of mouth breathing on outcome of scaling and root planing in chronic periodontitis. ( 30425839 )
2018
27
Evaluation of the effect of IL-36γ expression on chronic periodontitis by enhancing the MAPK and TLR4 signaling pathways: A basic research. ( 30443300 )
2018
28
Effect of periodontal therapy on maxillary sinus mucous membrane thickening in chronic periodontitis: A split-mouth study. ( 30443301 )
2018
29
Assessment of microRNA-144-5p and its putative targets in inflamed gingiva from chronic periodontitis patients. ( 30450635 )
2018
30
Association between Diabetic Retinopathy and Chronic Periodontitis-A Cross-Sectional Study. ( 30477167 )
2018
31
Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial. ( 30076613 )
2018
32
Oral Candida colonization in patients with chronic periodontitis. Is there any relationship? ( 30082174 )
2018
33
Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study. ( 30083446 )
2018
34
Association of vitamin D binding protein and vitamin D receptor gene polymorphisms in Iranian patients with chronic periodontitis. ( 30083974 )
2018
35
Oral hygiene instruction does not seem to have a distinct effect in patients with chronic periodontitis and high caries experience. ( 30097159 )
2018
36
Evaluation of peri-implant marginal tissues around tissue-level and bone-level implants in patients with a history of chronic periodontitis. ( 30107048 )
2018
37
Periopathogens in atherosclerotic plaques of patients with both cardiovascular disease and chronic periodontitis. ( 30108636 )
2018
38
Effects of non-surgical periodontal therapy on clinical and immunological profile and oral colonization of Candida spp in HIV-infected patients with chronic periodontitis. ( 30118537 )
2018
39
Estimation of Toll-like receptor 9 in gingival tissues of patients with chronic periodontitis with or without hyperlipidemia and its association with the presence of Porphyromonas gingivalis. ( 30131620 )
2018
40
Effect of nonsurgical periodontal therapy on plasma-reactive oxygen metabolite and gingival crevicular fluid resistin and serum resistin levels in obese and normal weight individuals with chronic periodontitis. ( 30131622 )
2018
41
Molecular Detection of Porphyromonas gingivalis in Chronic Periodontitis Patients. ( 30150503 )
2018
42
A Qualitative Analysis of Periodontal Pathogens in Chronic Periodontitis Patients after Nonsurgical Periodontal Therapy with and without Diode Laser Disinfection Using Benzoyl-DL Arginine-2-Naphthylamide Test: A Randomized Clinical Trial. ( 30166831 )
2018
43
Efficacy of Acacia arabica gum as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A randomized controlled clinical trial. ( 30166872 )
2018
44
Effect of Omega-3 Fatty Acids on Chronic Periodontitis Patients in Postmenopausal Women: A Randomised Controlled Clinical Study. ( 30175329 )
2018
45
Effects of Systemic Simvastatin on the Concentrations of Visfatin, Tumor Necrosis Factor-α, and Interleukin-6 in Gingival Crevicular Fluid in Patients with Type 2 Diabetes and Chronic Periodontitis. ( 30186882 )
2018
46
IL4 gene VNTR polymorphism in chronic periodontitis in end-stage renal disease patients. ( 30194905 )
2018
47
Assessment of Pyrexia and Associated Sickness Behavior in Patients with Chronic Periodontitis. ( 30199858 )
2018
48
Periodontal status in chronic periodontitis depressed patients on desvenlafaxine: An observational study. ( 30210195 )
2018
49
Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci. ( 30218097 )
2018
50
Evaluation of Association of Vitamin D Receptor Genetic Polymorphism with Severe Chronic Periodontitis in an Ethnic Tamilian Population. ( 30234384 )
2018
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Variations for Periodontitis, Chronic

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Expression for Periodontitis, Chronic

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Search GEO for disease gene expression data for Periodontitis, Chronic.
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Pathways for Periodontitis, Chronic

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Pathways related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.57 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.04 IL1B IL6 MMP1 TNFRSF11B TNFSF11
3
Th17 cell differentiation 37
Show member pathways
 12.39 IL1B IL6 TLR2
4
NF-kappaB Signaling 4
12.35 IL1B TLR2 TNFSF11
5
TRAF Pathway 64
Show member pathways
 12.29 IL1B TLR2 TNFRSF11B TNFSF11
6
Tuberculosis 37
12.03 IL1B IL6 TLR2
7
IL-1 Family Signaling Pathways 65
Show member pathways
 12.01 IL1B IL6 TLR2
8
Bacterial infections in CF airways 22
Show member pathways
 11.98 IL1B IL6 TLR2
9
Colorectal Cancer Metastasis 64
11.97 IL6 MMP1 TLR2
10
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 11.96 IL1B MMP1 MMP8 TLR2
11
Th1 Differentiation Pathway 65
Show member pathways
 11.81 IL1B IL6 TLR2
12
Osteoclast differentiation 37
11.79 IL1B TNFRSF11B TNFSF11
13
IL-17 Family Signaling Pathways 65
Show member pathways
 11.79 IL1B IL6 MMP1 TLR2
14
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.77 IL1B IL6 TLR2
15
Interleukin-4 and 13 signaling 66
11.71 IL1B IL6 MMP1
16
Amoebiasis 37
11.56 IL1B IL6 TLR2
17
Hepatitis C and Hepatocellular Carcinoma 1
11.39 IL6 MMP1
18
Interleukin-10 signaling 66
11.36 IL1B IL6
19
Differentiation Pathway 1
11.35 IL6 TNFSF11
20
Hematopoietic Stem Cell Differentiation 1
11.35 IL1B IL6
21
MSP-RON Signaling 64
11.34 IL1B TLR2
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.34 IL1B IL6 MMP1
23
Monoamine Transport 1
Show member pathways
 11.29 IL1B TNFRSF11B
24
Legionellosis 37
11.24 IL1B IL6 TLR2
25
African trypanosomiasis 37
11.19 IL1B IL6
26
IL-10 Pathway 64
11.19 IL1B IL6
27
Prion diseases 37
11.19 IL1B IL6
28
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.17 IL6 MMP1
29
Development and heterogeneity of the ILC family 1
11.14 IL1B IL6
30
Antifolate resistance 37
11.12 IL1B IL6
31
Malaria 37
11.12 IL1B IL6 TLR2
32
TNFs bind their physiological receptors 66
11.1 TNFRSF11B TNFSF11
33
Cytokines and Inflammatory Response 1
11.08 IL1B IL6
34
IL1 and megakaryocytes in obesity 1
11.01 IL1B TLR2
35
G-protein signaling_RhoB regulation pathway 22
11.01 IL1B IL6 TNFSF11
36
Rheumatoid arthritis 37
10.98 IL1B IL6 MMP1 TLR2 TNFSF11
37
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.91 IL1B IL6 TNFRSF11B TNFSF11
38
Osteoclast Signaling 1
10.77 TNFRSF11B TNFSF11
39
Osteoblast Signaling 1
10.69 TNFRSF11B TNFSF11
Sources

GO Terms for Periodontitis, Chronic

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Cellular components related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 IL1B IL6 MMP8 TNFRSF11B TNFSF11
2 extracellular matrix GO:0031012 9.33 MMP1 MMP8 TNFRSF11B
3 extracellular region GO:0005576 9.1 IL1B IL6 MMP1 MMP8 TNFRSF11B TNFSF11

Biological processes related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 IL1B IL6 TLR2 TNFSF11
2 immune response GO:0006955 9.78 IL1B IL6 TLR2 TNFSF11
3 inflammatory response GO:0006954 9.77 IL1B IL6 TLR2
4 regulation of signaling receptor activity GO:0010469 9.76 IL1B IL6 TNFRSF11B TNFSF11
5 cytokine-mediated signaling pathway GO:0019221 9.67 IL1B IL6 MMP1 TNFSF11
6 positive regulation of T cell proliferation GO:0042102 9.62 IL1B IL6
7 extracellular matrix disassembly GO:0022617 9.61 MMP1 MMP8
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.61 IL1B IL6 TNFSF11
9 positive regulation of tumor necrosis factor production GO:0032760 9.59 MMP8 TLR2
10 monocyte chemotaxis GO:0002548 9.58 IL6 TNFSF11
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B MMP8
12 positive regulation of JNK cascade GO:0046330 9.58 IL1B MMP8 TNFSF11
13 collagen catabolic process GO:0030574 9.57 MMP1 MMP8
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 IL1B TLR2
15 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.56 IL1B IL6 TLR2 TNFSF11
16 positive regulation of interleukin-8 production GO:0032757 9.55 IL1B TLR2
17 positive regulation of gene expression GO:0010628 9.55 IL1B IL6 MMP8 TLR2 TNFSF11
18 negative regulation of neurogenesis GO:0050768 9.54 IL1B IL6
19 positive regulation of chemokine production GO:0032722 9.52 IL6 TLR2
20 positive regulation of glial cell proliferation GO:0060252 9.51 IL1B IL6
21 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.5 IL1B MMP8 TLR2
22 negative regulation of bone resorption GO:0045779 9.49 IL6 TNFRSF11B
23 positive regulation of interleukin-6 production GO:0032755 9.26 IL1B IL6 MMP8 TLR2
24 positive regulation of neuroinflammatory response GO:0150078 8.8 IL1B IL6 MMP8

Molecular functions related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IL1B IL6 TNFRSF11B TNFSF11
Sources

Sources for Periodontitis, Chronic

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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