Periodontitis, Chronic disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRD040 MIFTS: 51	Periodontitis, Chronic Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Periodontitis, Chronic

MalaCards integrated aliases for Periodontitis, Chronic:

Name: Periodontitis, Chronic ⁵⁷

Chronic Periodontitis ⁵³ ¹⁶ ⁷¹ ⁷⁵ ³¹

Periodontitis, Adult ⁵⁷

Characteristics:

Inheritance:

Autosomal recessive ⁵⁷

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the digestive system

Diseases of oral cavity, salivary glands and jaws

Gingivitis and periodontal diseases

Chronic periodontitis

External Ids:

OMIM® ⁵⁷ 260950

ICD10 ³¹ K05.3

MedGen ⁴⁰ C0266929

EFO ¹⁶ EFO_0006343

UMLS ⁷¹ C0266929

Sources

Summaries for Periodontitis, Chronic

OMIM®: ⁵⁷ Chronic periodontitis, formerly called adult periodontitis, is the most frequently occurring form of periodontitis and is characterized by slowly progressing alveolar bone destruction and attachment loss. Although chronic periodontitis is most prevalent in adults and has a slow progression, it can occur in children and adolescents and may have periods of rapid progression (Armitage, 1999). (260950) (Updated 08-Dec-2022)

MalaCards based summary: Periodontitis, Chronic, also known as chronic periodontitis, is related to gingival recession and acute pericementitis. An important gene associated with Periodontitis, Chronic is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Metronidazole and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and bone marrow, and related phenotype is neoplasm.

Wikipedia: ⁷⁵ Chronic periodontitis is one of the seven categories of periodontitis as defined by the American Academy... more...

Sources

Related Diseases for Periodontitis, Chronic

Diseases in the Periodontitis family:

Periodontitis, Chronic

Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis, Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 500)

#	Related Disease	Score	Top Affiliating Genes
1	gingival recession	30.4	TNFSF11 MMP8 IL6 IL1B
2	acute pericementitis	30.2	TNFSF11 MMP8 IL6 IL1B
3	inflammatory bowel disease 1	29.9	IL6 IL1B
4	gingival overgrowth	29.9	MMP8 MMP1 IL6
5	necrotizing ulcerative gingivitis	29.9	IL6 IL1B
6	suppurative periapical periodontitis	29.8	IL6 IL1B
7	vaginitis	29.8	IL6 IL1B
8	complex regional pain syndrome	29.8	IL6 IL1B
9	bronchiectasis	29.8	MMP8 IL6 IL1B
10	chronic kidney disease	29.8	TNFSF11 TNFRSF11B IL6 IL1B
11	gastroesophageal reflux	29.8	IL6 IL1B DPP7
12	spondylitis	29.7	TNFSF11 IL6 IL1B
13	periodontitis, aggressive, 1	29.7	MMP8 MMP1
14	dry eye syndrome	29.7	IL6 IL1B
15	pulmonary disease, chronic obstructive	29.7	MMP8 MMP1 IL6 IL1B
16	pain agnosia	29.6	IL6 IL1B
17	lung disease	29.6	MMP8 IL6 IL1B
18	kidney disease	29.6	TNFSF11 TNFRSF11B IL6 IL1B
19	periapical periodontitis	29.5	TNFSF11 MMP8 IL6 IL1B
20	immune deficiency disease	29.5	TNFSF11 MMP8 IL6 IL1B
21	peptic ulcer disease	29.5	IL6 IL1B
22	arthritis	29.5	TNFSF11 MMP8 MMP1 IL6 IL1B
23	chronic apical periodontitis	29.4	TNFSF11 MMP8 IL6 IL1B
24	root resorption	29.4	TNFSF11 TNFRSF11B IL6 IL1B
25	spondyloarthropathy 1	29.4	TNFSF11 TNFRSF11B IL6 IL1B
26	bone disease	29.3	TNFSF11 TNFRSF11B IL6
27	pulpitis	29.2	MMP1 IL6 IL1B
28	type 1 diabetes mellitus	29.2	TNFSF11 TNFRSF11B IL6 IL1B
29	osteomyelitis	29.2	TNFSF11 MMP1 IL6 IL1B
30	rheumatoid arthritis	29.1	TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B
31	gingivitis	28.9	MMP8 MMP1 IL6 IL1B
32	cerebral palsy	28.9	MMP8 MMP1 IL6 IL1B
33	periodontitis	28.9	TNFSF11 MMP8 MMP1 IL6 IL1B
34	aggressive periodontitis	28.8	TNFSF11 MMP8 MMP1 IL6 IL1B
35	arthropathy	28.6	TNFSF11 TNFRSF11B MMP1 IL6 IL1B
36	gingival disease	28.6	TNFSF11 MMP8 MMP1 IL6 IL1B
37	osteoporosis	28.5	TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B
38	psoriatic arthritis	28.4	TNFSF11 TNFRSF11B MMP1 IL6 IL1B
39	osteoarthritis	28.4	TNFSF11 TNFRSF11B MMP1 IL6 IL1B
40	type 2 diabetes mellitus	10.8
41	diabetes mellitus	10.7
42	oto-palatal-digital syndrome	10.6
43	rickets	10.5
44	cytokine deficiency	10.5
45	coronary heart disease 1	10.4
46	rapidly involuting congenital hemangioma	10.4
47	leptin deficiency or dysfunction	10.4
48	active peptic ulcer disease	10.4
49	hair whorl	10.4
50	tobacco addiction	10.4

Comorbidity relations with Periodontitis, Chronic via Phenotypic Disease Network (PDN):

Acute Cystitis	Dental Caries
Heart Disease

Graphical network of the top 20 diseases related to Periodontitis, Chronic:

Sources

Symptoms & Phenotypes for Periodontitis, Chronic

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 08-Dec-2022)

Teeth:
periodontitis
periodontosis
gingival inflammation

Skull:
alveolar bone destruction

Misc:
adolescent onset

Clinical features from OMIM®:

260950 (Updated 08-Dec-2022)

MGI Mouse Phenotypes related to Periodontitis, Chronic:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.02	IL1B IL6 MMP1 MMP8 TNFSF11

Sources

Drugs & Therapeutics for Periodontitis, Chronic

Drugs for Periodontitis, Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 235)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Metronidazole

Approved

Phase 4

443-48-1, 69198-10-3

4173

Hyaluronic acid

Approved, Vet_approved

Phase 4

9004-61-9

53477741

Ciprofloxacin

Approved, Investigational

Phase 4

85721-33-1, 93107-08-5

2764

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Ethinylestradiol

Approved

Phase 4

57-63-6

5991

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Norgestimate

Approved, Investigational

Phase 4

35189-28-7

6540478

Moxifloxacin

Approved, Investigational

Phase 4

186826-86-8, 354812-41-2, 151096-09-2

152946

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Minocycline

Approved, Investigational

Phase 4

10118-90-8, 13614-98-7

54675783 5281021

Chlorhexidine

Approved, Vet_approved, Withdrawn

Phase 4

55-56-1

2713 9552079

Simvastatin

Approved

Phase 4

79902-63-9

54454

Lycopene

Approved, Investigational

Phase 4

502-65-8

446925

Licorice

Approved

Phase 4

Ethanol

Approved

Phase 4

64-17-5

702

Montelukast

Approved

Phase 4

158966-92-8

5281040

Turmeric

Approved, Experimental, Investigational

Phase 4

Dopamine

Approved

Phase 4

62-31-7, 51-61-6

681

Metamfetamine

Approved, Illicit, Withdrawn

Phase 4

537-46-2

10836

Albendazole

Approved, Vet_approved

Phase 4

54965-21-8

2082

Zoledronic acid

Approved

Phase 4

118072-93-8

68740

Hydrogen peroxide

Approved, Vet_approved

Phase 4

7722-84-1

784

Aspartic acid

Approved, Nutraceutical

Phase 4

56-84-8

5960

Melatonin

Approved, Nutraceutical, Vet_approved

Phase 4

73-31-4

896

Phenothiazine

Experimental, Vet_approved

Phase 4

92-84-2

7108

Immunologic Factors

Phase 4

Anti-Bacterial Agents

Phase 4

Anti-Infective Agents

Phase 4

Antiprotozoal Agents

Phase 4

Antiparasitic Agents

Phase 4

Adjuvants, Immunologic

Phase 4

Viscosupplements

Phase 4

Protective Agents

Phase 4

Aloe

Phase 4

Hormones

Phase 4

Estradiol 3-benzoate

Phase 4

Estradiol 17 beta-cypionate

Phase 4

Contraceptives, Oral, Combined

Phase 4

Contraceptives, Oral

Phase 4

Contraceptive Agents

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Norgestimate, ethinyl estradiol drug combination

Phase 4

Antioxidants

Phase 4

Superoxide Dismutase

Phase 4

Anti-Infective Agents, Local

Phase 4

Chlorhexidine gluconate

Phase 4

Rosuvastatin Calcium

Phase 4

147098-20-2

Antimetabolites

Phase 4

Hypolipidemic Agents

Phase 4

Anticholesteremic Agents

Phase 4

Interventional clinical trials:

(show top 50) (show all 363)

#	Name	Status	NCT ID	Phase	Drugs
1	Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial	Unknown status	NCT02735395	Phase 4	Metronidazole 250 (7 days);Metronidazole 400 (7 days);Metronidazole 250 (14 days);Metronidazole 400 (14 days);Amoxicillin
2	Effect of Probiotic Lactobacillus Reuteri-containing Lozenges (Prodentis) on Halitosis in Patients With Chronic Periodontitis	Unknown status	NCT02789436	Phase 4	L. reuteri Prodentis® lozenges
3	Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis	Unknown status	NCT00297531	Phase 4
4	Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone	Unknown status	NCT00296881	Phase 4
5	Evaluating the Adjunctive Effect of Stress Reduction Protocol in the Non-Surgical Periodontal Therapy of Chronic Periodontitis Subjects Associated With Stress: A Randomized Control Pilot Study	Unknown status	NCT02487862	Phase 4
6	Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care	Unknown status	NCT01195493	Phase 4
7	Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% (Hyadent BG®) and Enamel Matrix Derivative (Emdogain®) in Periodontal Regeneration: A Randomized Clinical Trial	Unknown status	NCT04274244	Phase 4	Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML;Enamel Matrix Proteins (Active comparator group)
8	Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection: Randomized Clinical Trial.	Unknown status	NCT03863249	Phase 4	ADJUNTIVE ANTIBIOTICS
9	Preparation and Analysis of Material, Biological and Clinical Parameters of Metronidazole-loaded Porous Matrices for Local Periodontitis Treatment	Unknown status	NCT03791099	Phase 4	Metronidazole
10	Filling of Periodontal Pockets With a Commercially Available Injectable Cross-linked Hyaluronic Acid Dental Filler Versus Oral Hygiene Alone, After Scaling and Root Planing and Chlorhexidine Disinfection, for the Treatment of Periodontitis: A Single-blinded, Multi Center, Prospective, Randomized Controlled Trial	Unknown status	NCT02391974	Phase 4
11	Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy	Unknown status	NCT01532674	Phase 4
12	Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole as Adjunctive Therapy to Mechanical Treatment of Patients With Chronic Periodontitis	Completed	NCT00805558	Phase 4	moxifloxacin;Ciprofloxacin plus metronidazole
13	Clinical and Microbiological Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers.	Completed	NCT01837199	Phase 4	Metronidazole plus Amoxicillin
14	Long-term Safety Evaluation of Minocycline Resistance After Treatment With Minocycline HCl Microspheres, 1 mg in Subjects With Chronic Periodontitis	Completed	NCT00668746	Phase 4	Minocycline HCl microspheres
15	Propolis Improves Periodontal Status and Glycemic Control in Subjects With Type 2 Diabetes Mellitus and Chronic Periodontitis: a Randomized Clinical Trial	Completed	NCT02794506	Phase 4	Propolis;Placebo
16	Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase	Completed	NCT04675385	Phase 4	0.2% hyaluronic acid gel
17	Effect of Scaling & Root Planing (SRP) Combined With Therapy Of Omega-3 Fatty Acid on Clinical Parameters and Serum Levels of C-Reactive Protein (CRP) in Chronic Periodontitis - A Randomised Control Trial.	Completed	NCT01997853	Phase 4	Omega 3 fatty acid;Placebo
18	EFFECT OF SRP WITH ADJUNCTIVE THERAPY OF HERBAL IMMUNOMODULATORS ON THE SERUM C REACTIVE PROTEIN (CRP) LEVELS & CLINICAL PARAMETERS IN CHRONIC PERIODONTITIS PATIENTS - A RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED, CLINICAL TRIAL.	Completed	NCT01997814	Phase 4	herbal immunomodulator;Placebo
19	Systemic Lycopene as an Adjunct to Scaling and Rootplaning in Chronic Periodontitis Patients With Type 2 Diabetes Mellitus	Completed	NCT02263352	Phase 4	Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
20	Clinical and Laboratory Effect of 0.8% Hyaluronic Acid Gel in Conventional Treatment of Moderate to Severe Chronic Periodontitis	Completed	NCT03311906	Phase 4	0.8% Hyaluronic Acid
21	Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis: Randomized Clinical Trial	Completed	NCT03025204	Phase 4
22	Efficacy of Complex Phytoadaptogenes as an Adjunct to Non-surgical Periodontal Treatment in Patients With Chronic Periodontitis: a Randomized Clinical Trial	Completed	NCT04623164	Phase 4	Cocktail from complex phytoadaptogens (CFA)
23	Clinical and Microbiological of Antimicrobial Photodynamic Therapy on Surgical Treatment of Chronic Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial.	Completed	NCT02734784	Phase 4
24	"Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial."	Completed	NCT02583841	Phase 4
25	The Effect Of SRP With Adjunctive Systemic Therapy Of Leukotriene Receptor Antagonist-Montelukast On The Serum C Reactive Protein Levels & Clinical Parameters In Chronic Periodontitis Patients - A Randomized Controlled Trial	Completed	NCT02014532	Phase 4	Montelukast;Placebo
26	The Use of Simvastatin Gel With Perforated Resorbable Membranes in the Treatment of Intrabony Defects in Chronic Periodontitis Patients (Clinical and Biochemical Study)	Completed	NCT03419429	Phase 4	Simvastatin
27	The Response of Periodontal Pathogens to the Respective or Combined Treatment of Scaling and Root Planning and Locally Delivered Minocycline in Patients With Chronic Periodontitis- a Short-term Randomized Clinical Trial	Completed	NCT02355977	Phase 4	minocycline
28	Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial.	Completed	NCT03368430	Phase 4	Placebo
29	Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients	Completed	NCT02442453	Phase 4	Topical application of curenext gel;Placebo
30	Efficacy of Adjunctive Photodynamic Therapy in Non-surgical Treatment of Chronic Periodontitis: a Randomized , Controlled Clinical Trial	Completed	NCT01034501	Phase 4
31	A Multicenter, Randomized, Examiner Blinded Study of Photoactivated Disinfection With Scaling and Root Planing in the Treatment of Chronic Periodontitis	Completed	NCT00297518	Phase 4
32	Local Drug Delivery of Aloe Vera Gel in Chronic Periodontitis Patients With Controlled Diabetes Mellitus	Completed	NCT02437747	Phase 4	SRP + Aloe
33	Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects	Completed	NCT02886676	Phase 4	Spirulina capsules
34	Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis.	Completed	NCT01211223	Phase 4	Administration of Metronidazole plus Amoxicillin
35	Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling in Patients With Advanced Chronic Periodontitis	Completed	NCT03498404	Phase 4
36	Clinically Evaluating the Effects of Topical Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis	Completed	NCT04964167	Phase 4
37	The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial)	Completed	NCT03783845	Phase 4
38	Regenerative Potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) Bone Graft in the Treatment of Intrabony Defects; A Comparative Clinico Radiographic Study.	Completed	NCT04767243	Phase 4	open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
39	Effects of Photodynamic Therapy on Clinical and Immunological Parameters in a Group of Periodontal Patients Undergoing Supportive Periodontal Therapy	Completed	NCT02666573	Phase 4
40	Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin: a Clinical Trial	Completed	NCT02641210	Phase 4	Albendazole
41	Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients	Completed	NCT01647282	Phase 4	locally-applied minocycline HCl (1 mg)
42	Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study	Completed	NCT02808988	Phase 4
43	"Efficacy of Nonsurgical Periodontal Therapy in Patients With Chronic Renal Disease and Periodontitis: A Biochemical and Microbiological Assay"	Completed	NCT02901743	Phase 4
44	Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response	Completed	NCT02197260	Phase 4	3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
45	Evaluation of Gingival Crevicular Fluid Transforming Growth Factor-β1 Level After Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft	Completed	NCT02218515	Phase 4
46	Comparative Evaluation of Treatment Of Infrabony Defects With and Without 1.2% Rosuvastatin Gel: In-Vivo Study	Completed	NCT03677297	Phase 4	Rosuvastatin
47	Efficacy of Locally Delivered Minocycline in Advanced Periodontitis. A Clinico-microbiological Study	Completed	NCT04076098	Phase 4	Minocycline Hydrochloride
48	Custom Tray Application of Peroxide Gel as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis: A 6-Month Randomized Trial	Completed	NCT03262701	Phase 4	Hydrogen Peroxide Gel, 13 weeks;Hydrogen Peroxide Gel, 26 weeks
49	Biochemical Efficacy of Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in the Treatment of Stage II Periodontitis: A Randomized Controlled Clinical Trial	Completed	NCT05241509	Phase 4	Cymbopogon citratus (lemongrass) oil gel
50	Efficacy of Adjunctive Photodynamic Therapy Using Light-emitting Diode in the Treatment of Chronic Periodontitis	Unknown status	NCT01330082	Phase 2, Phase 3

Search NIH Clinical Center for Periodontitis, Chronic

Sources

Genetic Tests for Periodontitis, Chronic

Sources

Anatomical Context for Periodontitis, Chronic

Organs/tissues related to Periodontitis, Chronic:

MalaCards : Bone, Neutrophil, Bone Marrow, Heart, Kidney, Ovary, Liver

Sources

Publications for Periodontitis, Chronic

Articles related to Periodontitis, Chronic:

(show top 50) (show all 6209)

#	Title	Authors	PMID	Year
1	Evidence of a substantial genetic basis for risk of adult periodontitis. ⁵⁷	Michalowicz BS...Schenkein HA	11128917	2000
2	Self-reported periodontal disease in a Virginia twin population. ⁵⁷	Corey LA...Schenkein HA	8106947	1993
3	Gingival crevicular fluid levels of oncostatin M in periodontal conditions. ⁵³ ⁶²	Thorat Manojkumar S...Raju A	20189410	2010
4	RANKL and OPG mRNA level after non-surgical periodontal treatment. ⁵³ ⁶²	Dereka XE...Vrotsos IA	20033478	2010
5	Periodontitis, periodontopathic bacteria and lactoferrin. ⁵³ ⁶²	Wakabayashi H...Yoshie H	20155438	2010
6	Serum levels of oncostatin M (a gp 130 cytokine): an inflammatory biomarker in periodontal disease. ⁵³ ⁶²	Pradeep AR...Raju A	20408777	2010
7	In vivo expression of Toll-like receptor 2, Toll-like receptor 4, CSF2 and LY64 in Chinese chronic periodontitis patients. ⁵³ ⁶²	Sun Y...Shu R	20233331	2010
8	Interleukin-6 (G-174C) and tumour necrosis factor-alpha (G-308A) gene polymorphisms in geriatric patients with chronic periodontitis. ⁵³ ⁶²	Costa AM...Bezerra AC	19555357	2010
9	The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus. ⁵³ ⁶²	Shin DS...Lee JM	20498757	2010
10	Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. ⁵³ ⁶²	Nakajima T...Yamazaki K	19602107	2010
11	Association of single nucleotide gene polymorphism at interleukin-1beta +3954, -511, and -31 in chronic periodontitis and aggressive periodontitis in Dravidian ethnicity. ⁵³ ⁶²	Shete AR...Banerjee M	20059418	2010
12	IL-1beta, TNF-alpha, total antioxidative status and microbiological findings in chronic periodontitis treated with fluorescence-controlled Er:YAG laser radiation. ⁵³ ⁶²	Dominguez A...Garcia-Nunez JA	20077495	2010
13	Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade. ⁵³ ⁶²	Hernandez Rios M...Gamonal J	19929954	2009
14	Genetic risk factors for periodontitis in a Japanese population. ⁵³ ⁶²	Kobayashi T...Yoshie H	19892918	2009
15	Alanine aminopeptidase and dipeptidyl peptidase IV in saliva of chronic periodontitis patients. ⁵³ ⁶²	Aemaimanan P...Taweechaisupapong S	19905950	2009
16	Association among interleukin-6 gene polymorphism, diabetes and periodontitis in a Chinese population. ⁵³ ⁶²	Xiao LM...Zhang JC	19549135	2009
17	Tumor necrosis factor-alpha -308G/A single nucleotide polymorphism and red-complex periodontopathogens are independently associated with increased levels of tumor necrosis factor-alpha in diseased periodontal tissues. ⁵³ ⁶²	Trombone AP...Garlet GP	19076989	2009
18	Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. ⁵³ ⁶²	Bostanci N...Belibasakis GN	19664151	2009
19	DNA methylation status of the IL8 gene promoter in oral cells of smokers and non-smokers with chronic periodontitis. ⁵³ ⁶²	Oliveira NF...de Souza AP	19659670	2009
20	Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in blood as markers for early atherosclerosis in subjects with chronic periodontitis. ⁵³ ⁶²	Soder PO...Soder B	18973519	2009
21	Interleukin-17, RANKL, and osteoprotegerin levels in gingival crevicular fluid from smoking and non-smoking patients with chronic periodontitis during initial periodontal treatment. ⁵³ ⁶²	Buduneli N...Kutukculer N	19656027	2009
22	Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes. ⁵³ ⁶²	Kalus AA...Dale BA	19712472	2009
23	Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease. ⁵³ ⁶²	Pradeep AR...Hadge P	19576791	2009
24	Interleukin-10 (-592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. ⁵³ ⁶²	Hu KF...Tsai CC	19210338	2009
25	MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy. ⁵³ ⁶²	Pirhan D...Berdeli A	19453573	2009
26	Salivary cytokine levels in subjects with chronic periodontitis and in periodontally healthy individuals: a cross-sectional study. ⁵³ ⁶²	Teles RP...Haffajee AD	19210336	2009
27	Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. ⁵³ ⁶²	Dutzan N...Vernal R	19419438	2009
28	Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis. ⁵³ ⁶²	Gani DK...Emmadi P	20407653	2009
29	Microbiological composition associated with vitamin D receptor gene polymorphism in chronic periodontitis. ⁵³ ⁶²	Borges MA...Feres M	19684957	2009
30	TLR4 as a risk factor for periodontal disease: a reappraisal. ⁵³ ⁶²	Ozturk A...Vieira AR	19426173	2009
31	The influence of chronic periodontitis on serum TNF-alpha, IL-6 and hs-CRP concentrations, and function of graft and survival of kidney transplant recipients. ⁵³ ⁶²	Blach A...Wiecek A	19191811	2009
32	[The correlation between interleukin-1 receptor antagonist genotype and coronary heart disease in patients with chronic periodontitis]. ⁵³ ⁶²	Chu M...Jiang H	19290417	2009
33	Increased expression of extracellular matrix metalloproteinase inducer is associated with matrix metalloproteinase-1 and -2 in gingival tissues from patients with periodontitis. ⁵³ ⁶²	Dong W...Huang Z	19515022	2009
34	Assessment of aprotinin influence on periodontal clinical status and matrix metalloproteinases 1, 2 and their tissue inhibitors saliva concentrations in patients with chronic periodontitis. ⁵³ ⁶²	Pietruska M...Wysocka J	19758971	2009
35	Analysis of the association between interleukin-1beta (+3954) gene polymorphism and chronic periodontitis in a sample of the south Indian population. ⁵³ ⁶²	Kaarthikeyan G...Anandan B	19336858	2009
36	TLR4 and IL-18 gene variants in chronic periodontitis: impact on disease susceptibility and severity. ⁵³ ⁶²	Noack B...Hoffmann T	19811440	2009
37	The impact of the IL-11:IL-17 ratio on the chronic periodontitis pathogenesis: a preliminary report. ⁵³ ⁶²	Yetkin Ay Z...Berker E	18992017	2009
38	Increase of gingival matured dendritic cells number in elderly patients with chronic periodontitis. ⁵³ ⁶²	Bodineau A...Seguier S	18771763	2009
39	The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome. ⁵³ ⁶²	Claudino M...Garlet GP	18725394	2008
40	Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis. ⁵³ ⁶²	Pirhan D...Berdeli A	18710412	2008
41	Saliva concentrations of RANKL and osteoprotegerin in smoker versus non-smoker chronic periodontitis patients. ⁵³ ⁶²	Buduneli N...Lappin DF	18727653	2008
42	Lack of association between the TNF-alpha -308 (G/A) genetic polymorphism and periodontal disease in Brazilians. ⁵³ ⁶²	Menezes NG...Colombo AP	19148387	2008
43	Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. ⁵³ ⁶²	Menezes R...Garlet GP	18634923	2008
44	An interleukin-1beta (IL-1beta) single-nucleotide polymorphism at position 3954 and red complex periodontopathogens independently and additively modulate the levels of IL-1beta in diseased periodontal tissues. ⁵³ ⁶²	Ferreira SB...Garlet GP	18541658	2008
45	Formation of osteoclast-like cells from peripheral blood of periodontitis patients occurs without supplementation of macrophage colony-stimulating factor. ⁵³ ⁶²	Tjoa ST...Everts V	18435789	2008
46	[Relationship between interleukin-6 gene-572C/G polymorphism and chronic periodontitis]. ⁵³ ⁶²	Guan ZM...Huang GQ	19031817	2008
47	Genetic markers of tumour necrosis factor alpha in aggressive and chronic periodontitis. ⁵³ ⁶²	Schulz S...Reichert S	18363738	2008
48	Prevotella intermedia induces matrix metalloproteinase-9 expression in human periodontal ligament cells. ⁵³ ⁶²	Guan SM...Wu JZ	18400000	2008
49	The effect of periodontal treatment on IL-6 production of peripheral blood monocytes in aggressive periodontitis and chronic periodontitis patients. ⁵³ ⁶²	Radvar M...Arab HR	18523355	2008
50	Interleukin-11, interleukin-1beta, interleukin-12 and the pathogenesis of inflammatory periodontal diseases. ⁵³ ⁶²	Yucel OO...Otlu H	18433382	2008

Sources

Genes for Periodontitis, Chronic

Genes related to Periodontitis, Chronic (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	MMP8	Matrix Metallopeptidase 8	Protein Coding	8.98	Novoseek inferred ⁵³	17122880 18360660 17076603 (more) 15025222 14687223 11846190
2	DPP7	Dipeptidyl Peptidase 7	Protein Coding	8.02	Novoseek inferred ⁵³	8884640
3	IL1B	Interleukin 1 Beta	Protein Coding	7.94	Novoseek inferred ⁵³	17348213 17093844 20059418 (more) 16896836 18360660 19336858 15460419 17458053 16022023 18433382 11495136 20077495 18541658 18315432 16708852 19664151 15002890 17116158 19419438
4	TNFSF11	TNF Superfamily Member 11	Protein Coding	7.76	Novoseek inferred ⁵³	17559623 17539720 17032122 (more) 18727653 19419438 19656027 18435789 18634923 17355365 20033478
5	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	7.54	Novoseek inferred ⁵³	17559623 19656027 17711477 (more) 18727653 20033478 18725394 18634923 16827732 17355365
6	MMP1	Matrix Metallopeptidase 1	Protein Coding	7.39	Novoseek inferred ⁵³	15257748 12622858 19758971 (more) 18710412 16774538 18973519 17590156 16899023 9933437
7	IL6	Interleukin 6	Protein Coding	7.33	Novoseek inferred ⁵³	16708852 19555357 15025214 (more) 19191811 15863389 15088881 17076613 20407653 18523355 15663749 15016034 15613080 16838563 19031817 14687223 17559636 15619685 12716337 19602107 16642902 17209781 19210336 19549135

Sources

Variations for Periodontitis, Chronic

Sources

Expression for Periodontitis, Chronic

Search GEO for disease gene expression data for Periodontitis, Chronic.

Sources

Pathways for Periodontitis, Chronic

Pathways related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.42	TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.93	IL1B IL6 MMP1 TNFRSF11B TNFSF11
3	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.64	MMP1 IL6 IL1B
4	Clock-controlled autophagy in bone metabolism ⁷⁴	11.48	TNFSF11 TNFRSF11B IL6
5	Burn wound healing ⁷⁴	11.42	MMP1 IL6 IL1B
6	Pluripotent stem cell differentiation pathway ⁷⁴	11.29	TNFSF11 IL6
7	Interleukin-10 signaling ⁶⁶	11.27	IL6 IL1B
8	IL6-mediated signaling events ⁶¹	11.24	TNFSF11 IL6
9	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.23	MMP1 IL6 IL1B
10	Monoamine transport ⁷⁴ Show member pathways Serotonin transporter activity ⁷⁴	11.22	TNFRSF11B IL1B
11	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ⁶¹	11.12	MMP1 IL6
12	IL 10 signaling pathway ⁶⁷	11.12	TNFSF11 IL6 IL1B
13	IL-10 Pathway ⁶⁴	11.11	IL6 IL1B
14	Type I collagen synthesis in the context of osteogenesis imperfecta ⁷⁴	11.08	TNFSF11 TNFRSF11B
15	Development and heterogeneity of the ILC family ⁷⁴	11.05	IL6 IL1B
16	Cytokines and inflammatory response ⁷⁴	11	IL6 IL1B
17	Prostaglandin signaling ⁷⁴	10.97	IL6 IL1B
18	LDL- influence on CD14 and TLR4 ⁷⁴	10.83	IL6 IL1B
19	NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence ⁷⁴	10.73	IL6 IL1B
20	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	10.61	MMP1 IL6 IL1B
21	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.58	TNFSF11 TNFRSF11B IL6 IL1B
22	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.56	IL6 IL1B

Sources

GO Terms for Periodontitis, Chronic

Cellular components related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.47	TNFSF11 TNFRSF11B MMP8 MMP1 IL6 IL1B

Biological processes related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	10.11	TNFSF11 MMP8 IL6 IL1B
2	extracellular matrix organization	GO:0030198	10	TNFRSF11B MMP8 MMP1
3	cytokine-mediated signaling pathway	GO:0019221	9.95	TNFSF11 IL6 IL1B
4	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.89	TNFSF11 IL6 IL1B
5	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.88	TNFSF11 IL6 IL1B
6	negative regulation of neurogenesis	GO:0050768	9.84	IL6 IL1B
7	positive regulation of interleukin-6 production	GO:0032755	9.8	MMP8 IL6 IL1B
8	positive regulation of glial cell proliferation	GO:0060252	9.76	IL6 IL1B
9	negative regulation of bone resorption	GO:0045779	9.73	IL6 TNFRSF11B
10	positive regulation of JNK cascade	GO:0046330	9.73	TNFSF11 MMP8 IL1B
11	regulation of neuroinflammatory response	GO:0150077	9.67	MMP8 IL6
12	vascular endothelial growth factor production	GO:0010573	9.46	IL6 IL1B
13	regulation of microglial cell activation	GO:1903978	9.26	MMP8 IL6
14	positive regulation of neuroinflammatory response	GO:0150078	9.1	MMP8 IL6 IL1B