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MCID: PRD040
MIFTS: 59

Periodontitis, Chronic

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Periodontitis, Chronic

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MalaCards integrated aliases for Periodontitis, Chronic:

Name: Periodontitis, Chronic 58 30
Chronic Periodontitis 56 17 74
Periodontitis, Adult 58

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
periodontitis, chronic:
Inheritance autosomal recessive inheritance
Onset and clinical course onset


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

OMIM 58 260950
ICD10 34 K05.3
MedGen 43 C0266929
UMLS 74 C0266929
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Summaries for Periodontitis, Chronic

About this section
OMIM : 58 Chronic periodontitis, formerly called adult periodontitis, is the most frequently occurring form of periodontitis and is characterized by slowly progressing alveolar bone destruction and attachment loss. Although chronic periodontitis is most prevalent in adults and has a slow progression, it can occur in children and adolescents and may have periods of rapid progression (Armitage, 1999). (260950)

MalaCards based summary : Periodontitis, Chronic, also known as chronic periodontitis, is related to chronic apical periodontitis and periodontitis. An important gene associated with Periodontitis, Chronic is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs sodium fluoride and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and neutrophil, and related phenotypes are gingivitis and periodontitis

Wikipedia : 77 Chronic periodontitis is a common disease of the oral cavity consisting of chronic inflammation of the... more...

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Related Diseases for Periodontitis, Chronic

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Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis, Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 chronic apical periodontitis 32.8 TNFRSF11B TNFSF11
2 periodontitis 30.3 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
3 root resorption 29.7 IL1B TNFRSF11B TNFSF11
4 arthritis 29.6 IL1B IL6 MMP1 TNFSF11
5 aggressive periodontitis 29.5 IL1B IL6 MMP1 MMP8 TNFSF11
6 osteomyelitis 29.4 IL1B IL6 TNFSF11
7 pulmonary disease, chronic obstructive 29.3 IL6 MMP1 TLR2
8 cerebral palsy 29.3 IL1B IL6 MMP8
9 osteoporosis 29.2 IL1B IL6 TNFRSF11B TNFSF11
10 inflammatory bowel disease 29.1 IL1B IL6 TLR2
11 bone resorption disease 29.1 IL6 TNFRSF11B TNFSF11
12 gingivitis 29.1 IL1B IL6 MMP8 TLR2
13 rheumatoid arthritis 28.7 IL1B IL6 MMP1 TLR2 TNFRSF11B TNFSF11
14 psoriatic arthritis 28.2 IL1B IL6 MMP1 TNFRSF11B TNFSF11
15 periapical periodontitis 28.0 IL1B IL6 MMP8 TLR2 TNFRSF11B TNFSF11
16 periodontal disease 27.4 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
17 necrotizing ulcerative gingivitis 11.4
18 periodontosis 11.1
19 diabetes mellitus 10.6
20 periapical granuloma 10.3 MMP8 TNFSF11
21 impotence 10.2
22 fungal keratitis 10.2 MMP8 TLR2
23 idiopathic hypercalciuria 10.2 IL1B TNFSF11
24 haemophilus influenzae 10.2 IL1B TLR2
25 congenital cytomegalovirus 10.2 IL1B TLR2
26 suppurative otitis media 10.2 IL1B TLR2
27 polyarticular onset juvenile idiopathic arthritis 10.2 TNFRSF11B TNFSF11
28 hemophilic arthropathy 10.2 TNFRSF11B TNFSF11
29 primary systemic mycosis 10.2 IL1B TLR2
30 multicentric reticulohistiocytosis 10.2 TNFRSF11B TNFSF11
31 kummell's disease 10.2 TNFRSF11B TNFSF11
32 paget disease of bone 5, juvenile-onset 10.2 TNFRSF11B TNFSF11
33 familial expansile osteolysis 10.2 TNFRSF11B TNFSF11
34 scrub typhus 10.2 IL1B TLR2
35 extrapulmonary tuberculosis 10.2 IL1B TLR2
36 tendinopathy 10.2 MMP1 MMP8
37 multicentric carpotarsal osteolysis syndrome 10.2 TNFRSF11B TNFSF11
38 tooth resorption 10.2 TNFRSF11B TNFSF11
39 heart disease 10.2
40 chronic ulcer of skin 10.2 MMP1 MMP8
41 glucocorticoid-induced osteoporosis 10.2 TNFRSF11B TNFSF11
42 ischemic bone disease 10.2 TNFRSF11B TNFSF11
43 pelvic organ prolapse 10.2 MMP1 MMP8
44 kashin-beck disease 10.2 IL1B MMP1
45 corneal edema 10.1 IL1B MMP1
46 legionellosis 10.1 IL1B TLR2
47 keratitis, hereditary 10.1 IL1B TLR2
48 endosteal hyperostosis, autosomal dominant 10.1 TNFRSF11B TNFSF11
49 coronary heart disease 1 10.1
50 bone remodeling disease 10.1 TNFRSF11B TNFSF11

Comorbidity relations with Periodontitis, Chronic via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries
Heart Disease

Graphical network of the top 20 diseases related to Periodontitis, Chronic:



Diseases related to Periodontitis, Chronic
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Symptoms & Phenotypes for Periodontitis, Chronic

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Human phenotypes related to Periodontitis, Chronic:

33
# Description HPO Frequency HPO Source Accession
1 gingivitis 33 HP:0000230
2 periodontitis 33 HP:0000704

Symptoms via clinical synopsis from OMIM:

58
Teeth:
periodontitis
periodontosis
gingival inflammation

Skull:
alveolar bone destruction

Misc:
adolescent onset

Clinical features from OMIM:

260950

MGI Mouse Phenotypes related to Periodontitis, Chronic:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
2 neoplasm MP:0002006 9.43 IL1B IL6 MMP1 MMP8 TLR2 TNFSF11
3 skeleton MP:0005390 9.02 IL1B IL6 TLR2 TNFRSF11B TNFSF11
Sources

Drugs & Therapeutics for Periodontitis, Chronic

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Drugs for Periodontitis, Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 265)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 3 7681-49-4
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
3
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable 443-48-1 4173
4
Epinephrine Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 51-43-4 5816
5
Racepinephrine Approved Phase 4,Phase 1,Phase 2,Not Applicable 329-65-7 838
6
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 2713 9552079
7
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Not Applicable 9004-61-9 53477741
8
Coal tar Approved Phase 4,Not Applicable 8007-45-2
9
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
10
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
11
Polyestradiol phosphate Approved Phase 4 28014-46-2
12
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
13
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
14
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
15
Montelukast Approved Phase 4 158966-92-8 5281040
16
Minocycline Approved, Investigational Phase 4,Phase 3 10118-90-8 5281021
17
Turmeric Approved, Experimental, Investigational Phase 4,Not Applicable
18
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
19
Pentetic acid Approved Phase 4 67-43-6
20
Edetic Acid Approved, Vet_approved Phase 4 60-00-4, 62-33-9 6049
21
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
22
Zoledronic Acid Approved Phase 4 118072-93-8 68740
23 Lycopene Approved, Investigational Phase 4,Phase 1,Phase 2 502-65-8 53477748
24
Atorvastatin Approved Phase 4,Phase 2,Phase 3 134523-00-5 60823
25
Alendronate Approved Phase 4,Phase 2,Phase 3 66376-36-1, 121268-17-5 2088
26
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
27
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
28
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 7440-70-2 271
29
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 73-31-4 896
30 Pharmaceutical Solutions Phase 4,Phase 3,Not Applicable
31 Listerine Phase 4,Phase 3
32 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
33 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
36 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Acidophilus Phase 4,Phase 3,Phase 2,Not Applicable
38 Epinephryl borate Phase 4,Phase 1,Phase 2,Not Applicable
39 Photosensitizing Agents Phase 4,Phase 2,Phase 3,Not Applicable
40 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
41 Immunologic Factors Phase 4,Phase 2,Not Applicable
42 Adjuvants, Immunologic Phase 4,Phase 2,Not Applicable
43 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Viscosupplements Phase 4,Phase 2,Not Applicable
45 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
46 Dermatologic Agents Phase 4,Phase 2,Phase 3,Not Applicable
47 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Not Applicable
48 Disinfectants Phase 4,Phase 3,Phase 2,Not Applicable
49 Omega 3 Fatty Acid Phase 4,Phase 2,Not Applicable,Early Phase 1
50 Hormones Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 373)
# Name Status NCT ID Phase Drugs
1 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
2 Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis Unknown status NCT02735395 Phase 4 Metronidazole 250 (7 days);Metronidazole 400 (7 days);Metronidazole 250 (14 days);Metronidazole 400 (14 days);Amoxicillin
3 Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
4 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
5 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
6 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
7 Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets Unknown status NCT02391974 Phase 4
8 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
9 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
10 Treatment of Periodontitis in Obese Individuals Unknown status NCT03103204 Phase 4
11 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
12 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
13 Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis Completed NCT02014532 Phase 4 Montelukast;Placebo
14 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed NCT02355977 Phase 4 minocycline
15 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
16 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
17 Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis Completed NCT03419429 Phase 4 Simvastatin
18 Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
19 Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
20 Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis Completed NCT01034501 Phase 4
21 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
22 Melatonin as an Adjunctive Therapy for Chronic Periodontitis. Completed NCT03368430 Phase 4 Placebo
23 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis Completed NCT02794506 Phase 4 Propolis;Placebo
24 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
25 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
26 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling Completed NCT03498404 Phase 4
27 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Completed NCT00297518 Phase 4
28 MTZ Plus AMX in the Treatment of Smokers and Non-smokers Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
29 Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease Completed NCT02901743 Phase 4
30 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
31 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin Completed NCT02641210 Phase 4 Albendazole
32 Moxifloxacin in Situ Gel to Treat Periodontal Pocket. Completed NCT02016157 Phase 4 Moxifloxacin
33 "Efficacy Of 1.2% Rosuvastatin Gel In The Management Of Infrabony Defects" Completed NCT03677297 Phase 4 Rosuvastatin
34 The Effects of Periodontal Therapy on Glycemic Control in Diabetic Patients Completed NCT03783845 Phase 4 amoxicillin and metronidazole
35 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
36 Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft Completed NCT02218515 Phase 4
37 Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis Completed NCT02808988 Phase 4
38 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)
39 A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
40 Atorvastatin as an Adjunct to DFDBA in Intrabony Defects Completed NCT03009097 Phase 4 DFDBA with atorvastatin
41 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
42 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
43 Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
44 Full-mouth and Partial-mouth Scaling and Root Planing in Type 2 Diabetic Subjects Completed NCT02062047 Phase 4 Chlorhexidine
45 Photodynamic Therapy During Supportive Periodontal Therapy Completed NCT02666573 Phase 4
46 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4 Sodium alendronate
47 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4 Doxicicline
48 Adjunctive Hydrogen Peroxide for Periodontal Therapy Recruiting NCT03262701 Phase 4 Hydrogen Peroxide Gel, 13 weeks;Hydrogen Peroxide Gel, 26 weeks
49 Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection. Recruiting NCT03863249 Phase 4 ADJUNTIVE ANTIBIOTICS
50 Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg Recruiting NCT03762915 Phase 4 minocycline HCl microspheres

Search NIH Clinical Center for Periodontitis, Chronic

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Genetic Tests for Periodontitis, Chronic

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Genetic tests related to Periodontitis, Chronic:

# Genetic test Affiliating Genes
1 Periodontitis, Chronic 30
Sources

Anatomical Context for Periodontitis, Chronic

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MalaCards organs/tissues related to Periodontitis, Chronic:

42
Bone, Heart, Neutrophil, Testes, Ovary, Endothelial, Kidney
Sources

Publications for Periodontitis, Chronic

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Articles related to Periodontitis, Chronic:

(show top 50) (show all 1973)
# Title Authors Year
1
Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis. ( 30303256 )
2019
2
Response to "Identification of genetic risk factors of aggressive periodontitis using genome-wide association studies in association with those of chronic periodontitis". ( 30900245 )
2019
3
Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. ( 30834192 )
2019
4
Association of Chronic Periodontitis on Alzheimer's Disease or Vascular Dementia. ( 30874308 )
2019
5
Effect of Initial Periodontal Therapy on Serum Nitric Oxide Levels in Chronic Periodontitis Patients with or without Type 2 Diabetes Mellitus. ( 31058635 )
2019
6
Effect of scaling and root planing on gingival crevicular fluid levels of adrenomedullin in chronic periodontitis patients with and without diabetes mellitus type 2: A clinico-biochemical study. ( 31070151 )
2019
7
Relevance of single-nucleotide polymorphism to the expression of resistin gene affecting serum and gingival crevicular fluid resistin levels in chronic periodontitis and type 2 diabetes mellitus: A randomized control clinical trial. ( 30983784 )
2019
8
Proinflammatory (CD14+CD16++) monocytes in type 2 diabetes mellitus patients with/without chronic periodontitis. ( 30820203 )
2019
9
Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus. ( 30755772 )
2019
10
Quantitative gingival crevicular fluid proteome in type 2 diabetes mellitus and chronic periodontitis. ( 30362201 )
2019
11
The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled trial. ( 30328031 )
2019
12
Disease severity, debridement approach and timing of drug modify outcomes of adjunctive azithromycin in non-surgical management of chronic periodontitis: a multivariate meta-analysis. ( 31029129 )
2019
13
Adipokine gene variability and plasma levels in patients with chronic periodontitis -a case-control study. ( 31038568 )
2019
14
Clinical efficacy of photodynamic therapy as an adjunct to scaling and root planing in the treatment of chronic periodontitis among cigarette smokers: A systematic review and meta-analysis. ( 31048015 )
2019
15
Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes. ( 31049901 )
2019
16
IL-37- and IL-35/IL-37-Producing Plasma Cells in Chronic Periodontitis. ( 31050915 )
2019
17
Clinical and Microbiological Effects of the Use of Erbium: Yttrium-Aluminum-Garnet Laser on Chronic Periodontitis in Addition to Nonsurgical Periodontal Treatment: A Randomized Clinical Trial-6 Months Follow-Up. ( 31050949 )
2019
18
There are probably no benefits from using ozone as an adjuvant to scaling and root planing in patients with chronic periodontitis. ( 31053236 )
2019
19
Association between Interleukin-10 Gene Polymorphisms and Severe Chronic Periodontitis. ( 31055876 )
2019
20
Association of receptor for advanced glycation end products g82s polymorphism with chronic periodontitis in type II diabetic and non-diabetic South Indians. ( 31078654 )
2019
21
Impact of Severe Chronic Periodontitis on Oral Health-related Quality of Life. ( 31093611 )
2019
22
Evaluation of prognosis related to compliance with supportive periodontal treatment in patients with chronic periodontitis: a clinical retrospective study. ( 31098329 )
2019
23
Association of Fc gamma-receptor genes polymorphisms with chronic periodontitis and Peri-Implantitis. ( 30887566 )
2019
24
Serum microRNAs and chronic periodontitis: A case-control study. ( 30889506 )
2019
25
Correlation of ABO Blood Groups and Rh Factor with The Severity of Generalized Chronic Periodontitis: Across Sectional Study in Riyadh, Saudi Arabia. ( 30894924 )
2019
26
Gingival crevicular fluid resistin levels in chronic periodontitis with type 2 diabetes before and after non-surgical periodontal therapy: A clinico-biochemical study. ( 30900656 )
2019
27
Do adjunctive statins improve periodontal treatment outcomes in patients with chronic periodontitis? ( 30903122 )
2019
28
Association of - 757T > C polymorphism of C-reactive protein gene with chronic periodontitis of South Indian population. ( 30903199 )
2019
29
Exosomal microRNA-155-5p from PDLSCs regulated Th17/Treg balance by targeting sirtuin-1 in chronic periodontitis. ( 31016751 )
2019
30
Effectiveness of scaling and root planning with and without adjunct antimicrobial photodynamic therapy in the treatment of chronic periodontitis among cigarette-smokers and never-smokers: A randomized controlled clinical trial. ( 30625398 )
2019
31
Polyhexamethylene guanidine phosphate irrigation as an adjunctive to scaling and root planing in the treatment of chronic periodontitis. ( 30632852 )
2019
32
Lycopene solid lipid microparticles with enhanced effect on gingival crevicular fluid protein carbonyl as a biomarker of oxidative stress in patients with chronic periodontitis. ( 30633595 )
2019
33
Molecular signatures of chronic periodontitis in gingiva: A genomic and proteomic analysis. ( 30653263 )
2019
34
Effect of local probiotic (Lactobacillus reuteri) vs systemic antibiotic therapy as an adjunct to non-surgical periodontal treatment in chronic periodontitis. ( 30663271 )
2019
35
Use of photobiomodulation induced by polarized polychromatic non-coherent light in the management of adult chronic periodontitis. ( 30666859 )
2019
36
Potential Effect of Tobacco Consumption Through Smoking and Chewing Tobacco on IL1beta Protein Expression in Chronic Periodontitis Patients: In Silico Molecular Docking Study. ( 30676974 )
2019
37
Bacteremia after professional mechanical plaque removal in patients with chronic periodontitis. ( 30680855 )
2019
38
UTILISATION OF ANTIMICROBIAL PHOTODYNAMIC THERAPY AS AN ADJUNCTIVE TOOL FOR OPEN FLAP DEBRIDEMENT IN THE MANAGEMENT OF CHRONIC PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL. ( 30684674 )
2019
39
Interleukin-21 and its association with chronic periodontitis. ( 30692738 )
2019
40
Evaluation of long-term effects of diode laser application in periodontal treatment of poorly controlled type 2 diabetic patients with chronic periodontitis. ( 30697968 )
2019
41
Chronic periodontitis and reduced respiratory function. ( 30712268 )
2019
42
Association between quality of sleep and chronic periodontitis: A case-control study in Malaysian population. ( 30745916 )
2019
43
Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview. ( 30755190 )
2019
44
Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis. ( 30765789 )
2019
45
Immediate Augmentation of Compromised Extraction Sockets in Chronic Periodontitis Patients: 1-Year Results of a Case Series on Volumetric and Histologic Response. ( 30794260 )
2019
46
Indocyanine green-based adjunctive antimicrobial photodynamic therapy for treating chronic periodontitis: A randomized clinical trial. ( 30807835 )
2019
47
Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis. ( 30814594 )
2019
48
Clinical, in vitro and phytochemical, studies of Scrophularia striata mouthwash on chronic periodontitis disease. ( 30991136 )
2019
49
Oxidative stress-related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta-analysis. ( 30989678 )
2019
50
Ozone application as adjunctive therapy in chronic periodontitis: Clinical, microbiological and biochemical aspects. ( 30988877 )
2019
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Variations for Periodontitis, Chronic

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Expression for Periodontitis, Chronic

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Search GEO for disease gene expression data for Periodontitis, Chronic.
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Pathways for Periodontitis, Chronic

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Pathways related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.57 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
2
Cytokine Signaling in Immune system 67
Show member pathways
 13.04 IL1B IL6 MMP1 TNFRSF11B TNFSF11
3
Th17 cell differentiation 38
Show member pathways
 12.39 IL1B IL6 TLR2
4
NF-kappaB Signaling 4
12.35 IL1B TLR2 TNFSF11
5
TRAF Pathway 65
Show member pathways
 12.29 IL1B TLR2 TNFRSF11B TNFSF11
6
Tuberculosis 38
12.03 IL1B IL6 TLR2
7
IL-1 Family Signaling Pathways 66
Show member pathways
 12.01 IL1B IL6 TLR2
8
Bacterial infections in CF airways 23
Show member pathways
 11.98 IL1B IL6 TLR2
9
Colorectal Cancer Metastasis 65
11.97 IL6 MMP1 TLR2
10
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 11.96 IL1B MMP1 MMP8 TLR2
11
Th1 Differentiation Pathway 66
Show member pathways
 11.81 IL1B IL6 TLR2
12
Osteoclast differentiation 38
11.79 IL1B TNFRSF11B TNFSF11
13
IL-17 Family Signaling Pathways 66
Show member pathways
 11.79 IL1B IL6 MMP1 TLR2
14
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.77 IL1B IL6 TLR2
15
Interleukin-4 and 13 signaling 67
11.71 IL1B IL6 MMP1
16
Amoebiasis 38
11.56 IL1B IL6 TLR2
17
Hepatitis C and Hepatocellular Carcinoma 1
11.39 IL6 MMP1
18
Interleukin-10 signaling 67
11.36 IL1B IL6
19
Differentiation Pathway 1
11.35 IL6 TNFSF11
20
Hematopoietic Stem Cell Differentiation 1
11.35 IL1B IL6
21
MSP-RON Signaling 65
11.34 IL1B TLR2
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.34 IL1B IL6 MMP1
23
Monoamine Transport 1
Show member pathways
 11.29 IL1B TNFRSF11B
24
Legionellosis 38
11.24 IL1B IL6 TLR2
25
African trypanosomiasis 38
11.22 IL1B IL6
26
IL-10 Pathway 65
11.19 IL1B IL6
27
Prion diseases 38
11.19 IL1B IL6
28
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.17 IL6 MMP1
29
Development and heterogeneity of the ILC family 1
11.14 IL1B IL6
30
Antifolate resistance 38
11.12 IL1B IL6
31
Malaria 38
11.12 IL1B IL6 TLR2
32
TNFs bind their physiological receptors 67
11.1 TNFRSF11B TNFSF11
33
Cytokines and Inflammatory Response 1
11.08 IL1B IL6
34
IL1 and megakaryocytes in obesity 1
11.01 IL1B TLR2
35
G-protein signaling_RhoB regulation pathway 23
11.01 IL1B IL6 TNFSF11
36
Rheumatoid arthritis 38
10.98 IL1B IL6 MMP1 TLR2 TNFSF11
37
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
10.91 IL1B IL6 TNFRSF11B TNFSF11
38
Osteoclast Signaling 1
10.77 TNFRSF11B TNFSF11
39
Osteoblast Signaling 1
10.69 TNFRSF11B TNFSF11
Sources

GO Terms for Periodontitis, Chronic

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Cellular components related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 IL1B IL6 MMP8 TNFRSF11B TNFSF11
2 extracellular matrix GO:0031012 9.33 MMP1 MMP8 TNFRSF11B
3 extracellular region GO:0005576 9.1 IL1B IL6 MMP1 MMP8 TNFRSF11B TNFSF11

Biological processes related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 IL1B IL6 TLR2 TNFSF11
2 immune response GO:0006955 9.78 IL1B IL6 TLR2 TNFSF11
3 inflammatory response GO:0006954 9.77 IL1B IL6 TLR2
4 regulation of signaling receptor activity GO:0010469 9.76 IL1B IL6 TNFRSF11B TNFSF11
5 cytokine-mediated signaling pathway GO:0019221 9.67 IL1B IL6 MMP1 TNFSF11
6 positive regulation of T cell proliferation GO:0042102 9.62 IL1B IL6
7 extracellular matrix disassembly GO:0022617 9.61 MMP1 MMP8
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.61 IL1B IL6 TNFSF11
9 monocyte chemotaxis GO:0002548 9.58 IL6 TNFSF11
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B MMP8
11 positive regulation of JNK cascade GO:0046330 9.58 IL1B MMP8 TNFSF11
12 collagen catabolic process GO:0030574 9.57 MMP1 MMP8
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 IL1B TLR2
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.56 IL1B IL6 TLR2 TNFSF11
15 positive regulation of interleukin-8 production GO:0032757 9.55 IL1B TLR2
16 positive regulation of gene expression GO:0010628 9.55 IL1B IL6 MMP8 TLR2 TNFSF11
17 negative regulation of neurogenesis GO:0050768 9.54 IL1B IL6
18 positive regulation of chemokine production GO:0032722 9.52 IL6 TLR2
19 positive regulation of glial cell proliferation GO:0060252 9.51 IL1B IL6
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.5 IL1B MMP8 TLR2
21 negative regulation of bone resorption GO:0045779 9.49 IL6 TNFRSF11B
22 positive regulation of tumor necrosis factor production GO:0032760 9.29 TLR2
23 positive regulation of interleukin-6 production GO:0032755 9.26 IL1B IL6 MMP8 TLR2
24 positive regulation of neuroinflammatory response GO:0150078 8.8 IL1B IL6 MMP8

Molecular functions related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IL1B IL6 TNFRSF11B TNFSF11
Sources

Sources for Periodontitis, Chronic

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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