MCID: PRD040
MIFTS: 60

Periodontitis, Chronic

Categories: Blood diseases, Gastrointestinal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Periodontitis, Chronic

MalaCards integrated aliases for Periodontitis, Chronic:

Name: Periodontitis, Chronic 58 30
Chronic Periodontitis 56 17 74
Periodontitis, Adult 58

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
periodontitis, chronic:
Inheritance autosomal recessive inheritance
Onset and clinical course onset


Classifications:



External Ids:

OMIM 58 260950
ICD10 34 K05.3
MedGen 43 C0266929
UMLS 74 C0266929

Summaries for Periodontitis, Chronic

OMIM : 58 Chronic periodontitis, formerly called adult periodontitis, is the most frequently occurring form of periodontitis and is characterized by slowly progressing alveolar bone destruction and attachment loss. Although chronic periodontitis is most prevalent in adults and has a slow progression, it can occur in children and adolescents and may have periods of rapid progression (Armitage, 1999). (260950)

MalaCards based summary : Periodontitis, Chronic, also known as chronic periodontitis, is related to chronic apical periodontitis and periodontitis. An important gene associated with Periodontitis, Chronic is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs sodium fluoride and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and neutrophil, and related phenotypes are gingivitis and periodontitis

Wikipedia : 77 Chronic periodontitis is a common disease of the oral cavity consisting of chronic inflammation of the... more...

Related Diseases for Periodontitis, Chronic

Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis, Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 chronic apical periodontitis 32.3 TNFRSF11B TNFSF11
2 periodontitis 30.2 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
3 root resorption 29.7 IL1B TNFRSF11B TNFSF11
4 arthritis 29.6 IL1B IL6 MMP1 TNFSF11
5 aggressive periodontitis 29.4 IL1B IL6 MMP1 MMP8 TNFSF11
6 osteomyelitis 29.4 IL1B IL6 TNFSF11
7 pulmonary disease, chronic obstructive 29.3 IL6 MMP1 TLR2
8 cerebral palsy 29.3 IL1B IL6 MMP8
9 osteoporosis 29.2 IL1B IL6 TNFRSF11B TNFSF11
10 inflammatory bowel disease 29.1 IL1B IL6 TLR2
11 bone resorption disease 29.1 IL6 TNFRSF11B TNFSF11
12 gingivitis 29.0 IL1B IL6 MMP8 TLR2
13 rheumatoid arthritis 28.7 IL1B IL6 MMP1 TLR2 TNFRSF11B TNFSF11
14 psoriatic arthritis 28.2 IL1B IL6 MMP1 TNFRSF11B TNFSF11
15 periapical periodontitis 28.0 IL1B IL6 MMP8 TLR2 TNFRSF11B TNFSF11
16 periodontal disease 27.4 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
17 necrotizing ulcerative gingivitis 11.4
18 periodontosis 11.1
19 diabetes mellitus 10.6
20 periapical granuloma 10.3 MMP8 TNFSF11
21 impotence 10.2
22 fungal keratitis 10.2 MMP8 TLR2
23 idiopathic hypercalciuria 10.2 IL1B TNFSF11
24 haemophilus influenzae 10.2 IL1B TLR2
25 congenital cytomegalovirus 10.2 IL1B TLR2
26 suppurative otitis media 10.2 IL1B TLR2
27 polyarticular onset juvenile idiopathic arthritis 10.2 TNFRSF11B TNFSF11
28 hemophilic arthropathy 10.2 TNFRSF11B TNFSF11
29 primary systemic mycosis 10.2 IL1B TLR2
30 multicentric reticulohistiocytosis 10.2 TNFRSF11B TNFSF11
31 kummell's disease 10.2 TNFRSF11B TNFSF11
32 paget disease of bone 5, juvenile-onset 10.2 TNFRSF11B TNFSF11
33 familial expansile osteolysis 10.2 TNFRSF11B TNFSF11
34 scrub typhus 10.2 IL1B TLR2
35 extrapulmonary tuberculosis 10.2 IL1B TLR2
36 tendinopathy 10.2 MMP1 MMP8
37 multicentric carpotarsal osteolysis syndrome 10.2 TNFRSF11B TNFSF11
38 tooth resorption 10.2 TNFRSF11B TNFSF11
39 chronic ulcer of skin 10.2 MMP1 MMP8
40 glucocorticoid-induced osteoporosis 10.2 TNFRSF11B TNFSF11
41 heart disease 10.2
42 ischemic bone disease 10.2 TNFRSF11B TNFSF11
43 pelvic organ prolapse 10.1 MMP1 MMP8
44 kashin-beck disease 10.1 IL1B MMP1
45 corneal edema 10.1 IL1B MMP1
46 legionellosis 10.1 IL1B TLR2
47 keratitis, hereditary 10.1 IL1B TLR2
48 endosteal hyperostosis, autosomal dominant 10.1 TNFRSF11B TNFSF11
49 coronary heart disease 1 10.1
50 bone remodeling disease 10.1 TNFRSF11B TNFSF11

Comorbidity relations with Periodontitis, Chronic via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries
Heart Disease

Graphical network of the top 20 diseases related to Periodontitis, Chronic:



Diseases related to Periodontitis, Chronic

Symptoms & Phenotypes for Periodontitis, Chronic

Human phenotypes related to Periodontitis, Chronic:

33
# Description HPO Frequency HPO Source Accession
1 gingivitis 33 HP:0000230
2 periodontitis 33 HP:0000704

Symptoms via clinical synopsis from OMIM:

58
Teeth:
periodontitis
periodontosis
gingival inflammation

Skull:
alveolar bone destruction

Misc:
adolescent onset

Clinical features from OMIM:

260950

MGI Mouse Phenotypes related to Periodontitis, Chronic:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
2 neoplasm MP:0002006 9.43 IL1B IL6 MMP1 MMP8 TLR2 TNFSF11
3 skeleton MP:0005390 9.02 IL1B IL6 TLR2 TNFRSF11B TNFSF11

Drugs & Therapeutics for Periodontitis, Chronic

Drugs for Periodontitis, Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 263)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 3 7681-49-4
2
Racepinephrine Approved Phase 4,Phase 1,Phase 2,Not Applicable 329-65-7 838
3
Epinephrine Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 51-43-4 5816
4
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Not Applicable 9004-61-9 53477741
5
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 2713 9552079
6
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable 443-48-1 4173
7
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
8
Coal tar Approved Phase 4,Not Applicable 8007-45-2
9
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
10
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
11
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
12
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
13
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
14
Polyestradiol phosphate Approved Phase 4 28014-46-2
15
Montelukast Approved Phase 4 158966-92-8 5281040
16
Minocycline Approved, Investigational Phase 4,Phase 3 10118-90-8 5281021
17
Turmeric Approved, Experimental, Investigational Phase 4,Not Applicable
18
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
19
Pentetic acid Approved Phase 4 67-43-6
20
Edetic Acid Approved, Vet_approved Phase 4 62-33-9, 60-00-4 6049
21
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
22
Zoledronic Acid Approved Phase 4 118072-93-8 68740
23 Lycopene Approved, Investigational Phase 4,Phase 1,Phase 2 502-65-8 53477748
24
Atorvastatin Approved Phase 4,Phase 2,Phase 3 134523-00-5 60823
25
Alendronate Approved Phase 4,Phase 2,Phase 3 66376-36-1, 121268-17-5 2088
26
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
27
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
28
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 7440-70-2 271
29
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 73-31-4 896
30 Listerine Phase 4,Phase 3
31 Pharmaceutical Solutions Phase 4,Phase 3,Not Applicable
32 Acidophilus Phase 4,Phase 3,Phase 2,Not Applicable
33 Photosensitizing Agents Phase 4,Phase 2,Phase 3,Not Applicable
34 Epinephryl borate Phase 4,Phase 1,Phase 2,Not Applicable
35 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
38 Adjuvants, Immunologic Phase 4,Phase 2,Not Applicable
39 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Viscosupplements Phase 4,Phase 2,Not Applicable
41 Immunologic Factors Phase 4,Phase 2,Not Applicable
42 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
43 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
44 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
45 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
46 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Not Applicable
47 Disinfectants Phase 4,Phase 3,Phase 2,Not Applicable
48 Dermatologic Agents Phase 4,Phase 2,Phase 3,Not Applicable
49 Omega 3 Fatty Acid Phase 4,Phase 2,Not Applicable,Early Phase 1
50 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 370)
# Name Status NCT ID Phase Drugs
1 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
2 Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
3 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
4 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
5 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
6 Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets Unknown status NCT02391974 Phase 4
7 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
8 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
9 Treatment of Periodontitis in Obese Individuals Unknown status NCT03103204 Phase 4
10 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
11 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
12 Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis Completed NCT02014532 Phase 4 Montelukast;Placebo
13 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed NCT02355977 Phase 4 minocycline
14 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
15 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
16 Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis Completed NCT03419429 Phase 4 Simvastatin
17 Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
18 Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
19 Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis Completed NCT01034501 Phase 4
20 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
21 Melatonin as an Adjunctive Therapy for Chronic Periodontitis. Completed NCT03368430 Phase 4 Placebo
22 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis Completed NCT02794506 Phase 4 Propolis;Placebo
23 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
24 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
25 Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling Completed NCT03498404 Phase 4
26 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Completed NCT00297518 Phase 4
27 MTZ Plus AMX in the Treatment of Smokers and Non-smokers Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
28 Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease Completed NCT02901743 Phase 4
29 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
30 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin Completed NCT02641210 Phase 4 Albendazole
31 Moxifloxacin in Situ Gel to Treat Periodontal Pocket. Completed NCT02016157 Phase 4 Moxifloxacin
32 "Efficacy Of 1.2% Rosuvastatin Gel In The Management Of Infrabony Defects" Completed NCT03677297 Phase 4 Rosuvastatin
33 The Effects of Periodontal Therapy on Glycemic Control in Diabetic Patients Completed NCT03783845 Phase 4 amoxicillin and metronidazole
34 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
35 Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft Completed NCT02218515 Phase 4
36 Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis Completed NCT02808988 Phase 4
37 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)
38 A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
39 Atorvastatin as an Adjunct to DFDBA in Intrabony Defects Completed NCT03009097 Phase 4 DFDBA with atorvastatin
40 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
41 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
42 Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
43 Full-mouth and Partial-mouth Scaling and Root Planing in Type 2 Diabetic Subjects Completed NCT02062047 Phase 4 Chlorhexidine
44 Photodynamic Therapy During Supportive Periodontal Therapy Completed NCT02666573 Phase 4
45 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4 Sodium alendronate
46 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4 Doxicicline
47 Adjunctive Hydrogen Peroxide for Periodontal Therapy Recruiting NCT03262701 Phase 4 Hydrogen Peroxide Gel, 13 weeks;Hydrogen Peroxide Gel, 26 weeks
48 Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection. Recruiting NCT03863249 Phase 4 ADJUNTIVE ANTIBIOTICS
49 Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis Active, not recruiting NCT02735395 Phase 4 Metronidazole 250 (7 days);Metronidazole 400 (7 days);Metronidazole 250 (14 days);Metronidazole 400 (14 days);Amoxicillin
50 Porous Metronidazole Loaded Matrix for Local Treatment of Periodontitis. Active, not recruiting NCT03791099 Phase 4 Metronidazole

Search NIH Clinical Center for Periodontitis, Chronic

Genetic Tests for Periodontitis, Chronic

Genetic tests related to Periodontitis, Chronic:

# Genetic test Affiliating Genes
1 Periodontitis, Chronic 30

Anatomical Context for Periodontitis, Chronic

MalaCards organs/tissues related to Periodontitis, Chronic:

42
Bone, Testes, Neutrophil, Endothelial, Heart, Ovary, Liver

Publications for Periodontitis, Chronic

Articles related to Periodontitis, Chronic:

(show top 50) (show all 1932)
# Title Authors Year
1
Response to "Identification of genetic risk factors of aggressive periodontitis using genome-wide association studies in association with those of chronic periodontitis". ( 30900245 )
2019
2
Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. ( 30834192 )
2019
3
Association of Chronic Periodontitis on Alzheimer's Disease or Vascular Dementia. ( 30874308 )
2019
4
Proinflammatory (CD14+CD16++) monocytes in type 2 diabetes mellitus patients with/without chronic periodontitis. ( 30820203 )
2019
5
Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus. ( 30755772 )
2019
6
Bacteremia after professional mechanical plaque removal in patients with chronic periodontitis. ( 30680855 )
2019
7
UTILISATION OF ANTIMICROBIAL PHOTODYNAMIC THERAPY AS AN ADJUNCTIVE TOOL FOR OPEN FLAP DEBRIDEMENT IN THE MANAGEMENT OF CHRONIC PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL. ( 30684674 )
2019
8
Interleukin-21 and its association with chronic periodontitis. ( 30692738 )
2019
9
Evaluation of Long-Term Effects of Diode Laser Application in Periodontal Treatment of Poor Controlled Type-2 Diabetic Patients with Chronic Periodontitis. ( 30697968 )
2019
10
Chronic periodontitis and reduced respiratory function. ( 30712268 )
2019
11
Association between quality of sleep and chronic periodontitis: A case-control study in Malaysian population. ( 30745916 )
2019
12
Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview. ( 30755190 )
2019
13
Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis. ( 30765789 )
2019
14
Immediate Augmentation of Compromised Extraction Sockets in Chronic Periodontitis Patients: 1-Year Results of a Case Series on Volumetric and Histologic Response. ( 30794260 )
2019
15
Indocyanine green-based adjunctive antimicrobial photodynamic therapy for treating chronic periodontitis: A randomized clinical trial. ( 30807835 )
2019
16
Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis. ( 30814594 )
2019
17
A randomized, double-blind, placebo-controlled multicenter study for evaluating the effects of fixed-dose combinations of vitamin C, vitamin E, lysozyme, and carbazochrome on gingival inflammation in chronic periodontitis patients. ( 30845920 )
2019
18
Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis. ( 30863202 )
2019
19
Macrophage Migration Inhibitory Factor Levels in Gingival Crevicular Fluid, Saliva, and Serum of Chronic Periodontitis Patients. ( 30868074 )
2019
20
The effect of nonsurgical periodontal therapy on pentraxin 3 levels in smokers and nonsmokers with chronic periodontitis. ( 30875312 )
2019
21
Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study. ( 30875931 )
2019
22
Periodontal Regenerative Therapy Using Enamel Matrix Derivative for Treatment of Generalized Severe Chronic Periodontitis: A 2-year Case Report. ( 30880297 )
2019
23
Periodontal Regenerative Therapy with Enamel Matrix Derivative in Patient with Chronic Periodontitis: A 3.5-year Follow-up Report. ( 30880299 )
2019
24
Association of Fc gamma-receptor genes polymorphisms with chronic periodontitis and Peri-Implantitis. ( 30887566 )
2019
25
Serum microRNAs and chronic periodontitis: A case-control study. ( 30889506 )
2019
26
Correlation of ABO Blood Groups and Rh Factor with The Severity of Generalized Chronic Periodontitis: Across Sectional Study in Riyadh, Saudi Arabia. ( 30894924 )
2019
27
Gingival crevicular fluid resistin levels in chronic periodontitis with type 2 diabetes before and after non-surgical periodontal therapy: A clinico-biochemical study. ( 30900656 )
2019
28
Do adjunctive statins improve periodontal treatment outcomes in patients with chronic periodontitis? ( 30903122 )
2019
29
Association of - 757T > C polymorphism of C-reactive protein gene with chronic periodontitis of South Indian population. ( 30903199 )
2019
30
DEFB1 rs11362 Polymorphism and Risk of Chronic Periodontitis: A Meta-Analysis of Unadjusted and Adjusted Data. ( 30915104 )
2019
31
Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis. ( 30384155 )
2019
32
Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: Results obtained from a meta-analysis. ( 30388570 )
2019
33
Effect of non-surgical periodontal therapy on salivary metabolic fingerprint of generalized chronic periodontitis using nuclear magnetic resonance spectroscopy. ( 30396039 )
2019
34
The effect of leukocyte-platelet-rich fibrin on bone morphogenetic protein-2 and insulin-like growth factor-1 levels in patients with chronic periodontitis: a randomized split mouth clinical trail. ( 30624092 )
2019
35
Effectiveness of scaling and root planning with and without adjunct antimicrobial photodynamic therapy in the treatment of chronic periodontitis among cigarette-smokers and never-smokers: A randomized controlled clinical trial. ( 30625398 )
2019
36
Polyhexamethylene guanidine phosphate irrigation as an adjunctive to scaling and root planing in the treatment of chronic periodontitis. ( 30632852 )
2019
37
Lycopene solid lipid microparticles with enhanced effect on gingival crevicular fluid protein carbonyl as a biomarker of oxidative stress in patients with chronic periodontitis. ( 30633595 )
2019
38
Molecular signatures of chronic periodontitis in gingiva: A genomic and proteomic analysis. ( 30653263 )
2019
39
Effect of local probiotic (Lactobacillus reuteri) vs systemic antibiotic therapy as an adjunct to non-surgical periodontal treatment in chronic periodontitis. ( 30663271 )
2019
40
Use of photobiomodulation induced by polarized polychromatic non-coherent light in the management of adult chronic periodontitis. ( 30666859 )
2019
41
Potential Effect of Tobacco Consumption Through Smoking and Chewing Tobacco on IL1beta Protein Expression in Chronic Periodontitis Patients: In Silico Molecular Docking Study. ( 30676974 )
2019
42
The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2 diabetes and/or smoking habit. ( 29737428 )
2019
43
Effect of Initial Periodontal Therapy on Salivary Trefoil Factor (TFF3) in otherwise Healthy Patients with Gingivitis and Chronic Periodontitis. ( 29962757 )
2018
44
Discrepancy of Clinical Parameters between the First and Second Molars Can Help to Differentiate Subjects with Aggressive Periodontitis from Chronic Periodontitis: a Cross-sectional Study Based on a Large Chinese Population. ( 29808177 )
2018
45
Association of Tumor Necrosis Factor-I+ (TNF-I+) Gene Promoter Polymorphisms with Aggressive and Chronic Periodontitis in Eastern Indian population. ( 29449347 )
2018
46
Clinical efficacy of subgingivally-delivered 0.75% boric acid gel as an adjunct to mechanotherapy in chronic periodontitis: A randomized, controlled clinical trial. ( 28474437 )
2018
47
Radiographic morphology of intrabony defects in the first molars of patients with localized aggressive periodontitis: Comparison with health and chronic periodontitis. ( 29660823 )
2018
48
The effects of a desiccant agent in the treatment of chronic periodontitis: a randomized, controlled clinical trial. ( 28624914 )
2018
49
Patients with chronic periodontitis present increased risk for primary SjAPgren syndrome: a nationwide population-based cohort study. ( 29942713 )
2018
50
Indocyanine green-mediated photothermal therapy in treatment of chronic periodontitis: A clinico-microbiological study. ( 29962701 )
2018

Variations for Periodontitis, Chronic

Expression for Periodontitis, Chronic

Search GEO for disease gene expression data for Periodontitis, Chronic.

Pathways for Periodontitis, Chronic

Pathways related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
2
Show member pathways
13.04 IL1B IL6 MMP1 TNFRSF11B TNFSF11
3
Show member pathways
12.39 IL1B IL6 TLR2
4 12.35 IL1B TLR2 TNFSF11
5
Show member pathways
12.29 IL1B TLR2 TNFRSF11B TNFSF11
6 12.03 IL1B IL6 TLR2
7
Show member pathways
12.01 IL1B IL6 TLR2
8
Show member pathways
11.98 IL1B IL6 TLR2
9 11.97 IL6 MMP1 TLR2
10
Show member pathways
11.96 IL1B MMP1 MMP8 TLR2
11
Show member pathways
11.81 IL1B IL6 TLR2
12 11.79 IL1B TNFRSF11B TNFSF11
13
Show member pathways
11.79 IL1B IL6 MMP1 TLR2
14
Show member pathways
11.77 IL1B IL6 TLR2
15 11.71 IL1B IL6 MMP1
16 11.56 IL1B IL6 TLR2
17 11.39 IL6 MMP1
18 11.36 IL1B IL6
19 11.35 IL6 TNFSF11
20 11.35 IL1B IL6
21 11.34 IL1B TLR2
22
Show member pathways
11.34 IL1B IL6 MMP1
23
Show member pathways
11.29 IL1B TNFRSF11B
24 11.24 IL1B IL6 TLR2
25 11.22 IL1B IL6
26 11.19 IL1B IL6
27 11.19 IL1B IL6
28 11.17 IL6 MMP1
29 11.14 IL1B IL6
30 11.12 IL1B IL6
31 11.12 IL1B IL6 TLR2
32 11.1 TNFRSF11B TNFSF11
33 11.08 IL1B IL6
34 11.01 IL1B TLR2
35 11.01 IL1B IL6 TNFSF11
36 10.98 IL1B IL6 MMP1 TLR2 TNFSF11
37 10.91 IL1B IL6 TNFRSF11B TNFSF11
38 10.77 TNFRSF11B TNFSF11
39 10.69 TNFRSF11B TNFSF11

GO Terms for Periodontitis, Chronic

Cellular components related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 IL1B IL6 MMP8 TNFRSF11B TNFSF11
2 extracellular matrix GO:0031012 9.33 MMP1 MMP8 TNFRSF11B
3 extracellular region GO:0005576 9.1 IL1B IL6 MMP1 MMP8 TNFRSF11B TNFSF11

Biological processes related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 IL1B IL6 TLR2 TNFSF11
2 immune response GO:0006955 9.78 IL1B IL6 TLR2 TNFSF11
3 inflammatory response GO:0006954 9.77 IL1B IL6 TLR2
4 regulation of signaling receptor activity GO:0010469 9.76 IL1B IL6 TNFRSF11B TNFSF11
5 cytokine-mediated signaling pathway GO:0019221 9.67 IL1B IL6 MMP1 TNFSF11
6 positive regulation of T cell proliferation GO:0042102 9.62 IL1B IL6
7 extracellular matrix disassembly GO:0022617 9.61 MMP1 MMP8
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.61 IL1B IL6 TNFSF11
9 monocyte chemotaxis GO:0002548 9.58 IL6 TNFSF11
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B MMP8
11 positive regulation of JNK cascade GO:0046330 9.58 IL1B MMP8 TNFSF11
12 collagen catabolic process GO:0030574 9.57 MMP1 MMP8
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 IL1B TLR2
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.56 IL1B IL6 TLR2 TNFSF11
15 positive regulation of interleukin-8 production GO:0032757 9.55 IL1B TLR2
16 positive regulation of gene expression GO:0010628 9.55 IL1B IL6 MMP8 TLR2 TNFSF11
17 negative regulation of neurogenesis GO:0050768 9.54 IL1B IL6
18 positive regulation of chemokine production GO:0032722 9.52 IL6 TLR2
19 positive regulation of glial cell proliferation GO:0060252 9.51 IL1B IL6
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.5 IL1B MMP8 TLR2
21 negative regulation of bone resorption GO:0045779 9.49 IL6 TNFRSF11B
22 positive regulation of tumor necrosis factor production GO:0032760 9.29 TLR2
23 positive regulation of interleukin-6 production GO:0032755 9.26 IL1B IL6 MMP8 TLR2
24 positive regulation of neuroinflammatory response GO:0150078 8.8 IL1B IL6 MMP8

Molecular functions related to Periodontitis, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IL1B IL6 TNFRSF11B TNFSF11

Sources for Periodontitis, Chronic

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