MCID: PRD003
MIFTS: 46

Periodontosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Periodontosis

MalaCards integrated aliases for Periodontosis:

Name: Periodontosis 12 15 73
Periodontitis, Juvenile 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9893
ICD10 33 K05.4
ICD9CM 35 523.5
MeSH 44 D010520
UMLS 73 C0600298

Summaries for Periodontosis

MalaCards based summary : Periodontosis, also known as periodontitis, juvenile, is related to periodontitis and gingivitis. An important gene associated with Periodontosis is F12 (Coagulation Factor XII), and among its related pathways/superpathways are Innate Immune System and Kaposi's sarcoma-associated herpesvirus infection. The drugs Moxifloxacin and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and monocytes, and related phenotypes are Increased shRNA abundance and hematopoietic system

Wikipedia : 76 Periodontosis is an obsolete term that was used to describe what was once thought to be certain type of... more...

Related Diseases for Periodontosis

Diseases related to Periodontosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 periodontitis 30.5 CXCL8 MMP9 TLR4 TNFSF11
2 gingivitis 30.4 CD79A CXCL8 ELANE MMP9
3 periodontal disease 28.5 CD79A CXCL8 ELANE MMP9 TLR4 TNFSF11
4 papillon-lefevre syndrome 11.4
5 ehlers-danlos syndrome, periodontal type, 1 11.1
6 selective igg deficiency disease 11.0 CD40LG CD79A
7 c1q nephropathy 11.0 CD40LG CD79A
8 meningovascular neurosyphilis 10.9 CD40LG CD79A
9 alpha chain disease 10.9 CD40LG CD79A
10 brill-zinsser disease 10.9 CD40LG CD79A
11 cork-handlers' disease 10.9 CD40LG CD79A
12 salpingo-oophoritis 10.9 CD40LG CD79A
13 early yaws 10.9 CD40LG CD79A
14 ventilation pneumonitis 10.9 CD40LG CD79A
15 chronic interstitial cystitis 10.9 CD40LG CD79A
16 axillary adenitis 10.9 CD40LG CD79A
17 cryofibrinogenemia 10.9 CD40LG CD79A
18 trichostrongyloidiasis 10.9 CD40LG CD79A
19 toxicodendron dermatitis 10.9 CXCL8 SELL
20 subacute bacterial endocarditis 10.9 CD40LG CD79A
21 periodontal ehlers-danlos syndrome 10.9
22 heterophyiasis 10.9 CD40LG CD79A
23 immunoglobulin g deficiency 10.9 CD40LG CD79A
24 granulocytopenia 10.9 ITGAM SELL
25 orbital granuloma 10.9 CD40LG CD79A
26 transient hypogammaglobulinemia of infancy 10.9 CD40LG CD79A
27 hyperglobulinemic purpura 10.9 CD40LG CD79A
28 gastroduodenitis 10.9 CD40LG CD79A
29 bacterial conjunctivitis 10.9 CD40LG CD79A
30 heavy chain disease 10.9 CD40LG CD79A
31 ophthalmia neonatorum 10.9 CD40LG CD79A
32 immunoglobulin a deficiency 1 10.9 CD40LG CD79A
33 cerebral arteritis 10.9 CD40LG CD79A
34 selective immunoglobulin deficiency disease 10.9 CD40LG CD79A
35 geniculate herpes zoster 10.8 CD40LG CD79A
36 sporotrichosis 10.8 CD40LG CD79A
37 fallopian tube disease 10.8 CD40LG CD79A
38 hyperimmunoglobulin syndrome 10.8 CD40LG CD79A
39 chronic follicular conjunctivitis 10.8 CD79A MMP9
40 congenital syphilis 10.8 CD40LG CD79A
41 polyclonal hypergammaglobulinemia 10.8 CD40LG CD79A
42 salpingitis 10.8 CD40LG CD79A
43 juvenile dermatitis herpetiformis 10.8 CD79A HLA-A
44 ocular toxoplasmosis 10.8 CD40LG CD79A
45 dysgammaglobulinemia 10.8 CD40LG CD79A
46 vibratory urticaria 10.7 CXCL8 MMP9
47 congenital hypogammaglobulinemia 10.7 CD40LG CD79A
48 acute maxillary sinusitis 10.7 CD40LG CD79A
49 blepharochalasis 10.7 CD79A MMP9
50 chronic polyneuropathy 10.7 CD40LG CD79A

Comorbidity relations with Periodontosis via Phenotypic Disease Network (PDN):


Dental Caries

Graphical network of the top 20 diseases related to Periodontosis:



Diseases related to Periodontosis

Symptoms & Phenotypes for Periodontosis

GenomeRNAi Phenotypes related to Periodontosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 CD79A CTSS ITGAM SELL

MGI Mouse Phenotypes related to Periodontosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 TNFSF11 ELANE ITGAM MMP9 MPO PTGES
2 homeostasis/metabolism MP:0005376 10 ELANE F12 ITGAM KLK4 MMP9 MPO
3 immune system MP:0005387 9.7 TNFSF11 ELANE ITGAM MMP9 MPO PTGES
4 neoplasm MP:0002006 9.1 TNFSF11 ELANE MMP9 SELL CD79A TLR4

Drugs & Therapeutics for Periodontosis

Drugs for Periodontosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
2 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
3
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
4
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
5
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
8
Polyestradiol phosphate Approved Phase 4 28014-46-2
9
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
10 Fluoroquinolones Phase 4
11 Contraceptive Agents Phase 4
12 Contraceptives, Oral Phase 4
13 Contraceptives, Oral, Combined Phase 4
14 Anesthetics Phase 4
15 Topoisomerase Inhibitors Phase 4
16 Norgestimate, ethinyl estradiol drug combination Phase 4
17 Nucleic Acid Synthesis Inhibitors Phase 4
18 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
19 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
20 Estradiol 17 beta-cypionate Phase 4
21 Estradiol 3-benzoate Phase 4
22 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
23 Antiparasitic Agents Phase 4,Phase 2,Phase 3
24 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
25 Chlorhexidine gluconate Phase 4
26 Anesthetics, Local Phase 4
27
Clarithromycin Approved Phase 2, Phase 3,Phase 3,Not Applicable 81103-11-9 84029
28
Aspirin Approved, Vet_approved Phase 2, Phase 3,Phase 3 50-78-2 2244
29 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
30 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
31 Analgesics Phase 2, Phase 3,Phase 3
32 Fibrinolytic Agents Phase 2, Phase 3,Phase 3
33 Cyclooxygenase Inhibitors Phase 2, Phase 3,Phase 3
34 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
35 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
36 Platelet Aggregation Inhibitors Phase 2, Phase 3,Phase 3
37 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3
38 Antipyretics Phase 2, Phase 3,Phase 3
39 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 3
40 Antirheumatic Agents Phase 2, Phase 3,Phase 3
41 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3,Phase 3
42
Nitric Oxide Approved 10102-43-9 145068 160954
43
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
44
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
45 Micronutrients
46 Tolonium Chloride Not Applicable
47 Trace Elements
48 Dihydroxycholecalciferols
49 Ergocalciferols
50 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
2 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
3 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
4 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
5 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
6 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
7 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Recruiting NCT03025204 Phase 4
8 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
9 Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
10 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093207 Phase 2, Phase 3 Aspirin
11 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093246 Phase 2, Phase 3 Aspirin
12 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
13 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307 Not Applicable
14 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596 Not Applicable
15 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
16 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533
17 Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis Completed NCT03512938 Not Applicable
18 Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis Completed NCT03412331 Not Applicable
19 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 Completed NCT02927704
20 Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP Completed NCT02817568
21 Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels Completed NCT03034824 Not Applicable
22 Clarithromycin as Adjuvant to Periodontal Debridement Completed NCT02829983 Not Applicable Clarithromycin;Placebo
23 Smoking Influence on Apoptosis in Periodontitis Completed NCT02111005
24 Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy Completed NCT03142776 Not Applicable systemic clarithromycin
25 Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System Completed NCT02190773
26 Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease Completed NCT03128502
27 Nitro-oxidative Stress in Periodontitis Completed NCT02127203
28 TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases Completed NCT03558906
29 Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease Completed NCT03527901
30 The Importance of Periostin in Periodontal Health and Disease Completed NCT01180920
31 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3 Completed NCT03078595
32 Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects Completed NCT03399279 Not Applicable
33 Immediate Implant Placement in Aggressive Periodontitis Recruiting NCT03218228 Not Applicable
34 Mechanisms and Treatment Response of Aggressive Periodontitis in Children Recruiting NCT01330719 Not Applicable
35 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Recruiting NCT03090282
36 EMD for Treatment of Proximal Class-II Furcation Involvements Recruiting NCT03320135 Not Applicable
37 B Cell Functions in Periodontitis Recruiting NCT02833285
38 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Recruiting NCT03225950
39 Comparison Between Surgical Access and Repeated Applications of APDT Active, not recruiting NCT03140059 Not Applicable
40 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045
41 Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis Not yet recruiting NCT03340012 Not Applicable
42 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Terminated NCT01993368 Not Applicable

Search NIH Clinical Center for Periodontosis

Genetic Tests for Periodontosis

Anatomical Context for Periodontosis

MalaCards organs/tissues related to Periodontosis:

41
Bone, B Cells, Monocytes, Testes, Whole Blood, Neutrophil

Publications for Periodontosis

Articles related to Periodontosis:

(show top 50) (show all 139)
# Title Authors Year
1
Xyloglucan Based In Situ Gel of Lidocaine HCl for the Treatment of Periodontosis. ( 27034908 )
2016
2
Periodontosis: A Ninety-Year History: The Legacy of Professor Bernhard Gottlieb. ( 25152003 )
2014
3
An evaluation of statistical methods for the determination of age of death using dental root translucency and periodontosis. ( 20345796 )
2010
4
Long term evaluation of biomaterial application in surgical treatment of periodontosis. ( 19075328 )
2008
5
Polymorphisms within the IL-1 gene cluster: effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. ( 17335371 )
2007
6
Periodontal and hematological characteristics associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. ( 16460255 )
2006
7
Cytokine profiles in peripheral blood and whole blood cell cultures associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. ( 16332240 )
2005
8
Regenerative treatment of serious periodontosis with grafting of cancellous iliac bone and gingival flaps and replanting of patients' teeth. ( 12040204 )
2002
9
Reconstruction of the severely atrophic maxilla in a young adult with periodontosis. ( 10363501 )
1999
10
Hereditary palmoplantar keratoderma with nail changes and periodontosis in a father and son. ( 10071731 )
1999
11
Hypertension medication and periodontosis. ( 9153848 )
1997
12
Juvenile periodontitis (periodontosis)--Part 1. ( 1810674 )
1991
13
Periodontosis case report: 20-year follow-up with laboratory findings. ( 3269551 )
1988
14
Juvenile periodontitis (periodontosis) in a Nigerian teaching hospital. ( 3135397 )
1988
15
Treatment of localized juvenile periodontitis (periodontosis). A review. ( 3543283 )
1987
16
Radiographic evaluation of juvenile periodontitis (periodontosis). ( 3473226 )
1987
17
A syndrome of keratosis palmo-plantaris congenita, pes planus, onychogryphosis, periodontosis, arachnodactyly and a peculiar acro-osteolysis. ( 2943312 )
1986
18
Juvenile periodontitis (periodontosis) and inheritance patterns. ( 3855787 )
1985
19
Hyperkeratosis, periodontosis, and chronic pyogenic infections in a 15-year-old boy. Part One. ( 6742519 )
1984
20
Clinical, microbiological and immunological features associated with the treatment of active periodontosis lesions. ( 6386896 )
1984
21
Hyperkeratosis palmoplantaris with periodontosis. "Papillon-LeFevre syndrome". Report of three cases in the same family. ( 6241143 )
1984
22
Hyperkeratosis, periodontosis, and chronic pyogenic infections in a 15-year-old boy. Part Two. ( 6742526 )
1984
23
Periodontosis - a sixteen year case report. ( 6964151 )
1982
24
Juvenile periodontitis (periodontosis). Literature review and case reports. ( 6960334 )
1982
25
Early diagnosis and successful management of periodontosis. ( 7050211 )
1982
26
Autogenous transplants in the treatment of juvenile periodontitis (periodontosis). ( 6957470 )
1982
27
Clinical evaluation of localized periodontosis defects treated with freeze-dried bone allografts combined with local and systemic tetracyclines. ( 6757167 )
1982
28
Bacterial interference in the oral ecology of Actinobacillus actinomycetemcomitans and its relationship to human periodontosis. ( 6951532 )
1982
29
Juvenile periodontitis/periodontosis: historical overview and update. ( 6751882 )
1982
30
Gingival crevice neutrophil function in periodontosis. ( 6752372 )
1982
31
Periodontosis. Part II: Diagnosis and classification. ( 7026005 )
1981
32
An update on periodontosis. ( 6944157 )
1981
33
A rational approach to the management of periodontosis. ( 6954140 )
1981
34
Periodontosis. Part III: Barbados study. ( 6115707 )
1981
35
Immunologic study of human periodontosis (juvenile periodontitis). ( 6782228 )
1981
36
Periodontosis. Case, analysis and treatment. ( 7047428 )
1981
37
Periodontosis - a positive prognosis. ( 6954141 )
1981
38
IgG and IgG subclasses in human periodontosis (juvenile periodontitis). Serum concentrations. ( 6785410 )
1981
39
Tooth transplantation--a treatment modality in periodontosis. ( 7026004 )
1981
40
A comparison of identical twins in relation to three dental anomalies: multiple supernumerary teeth, juvenile periodontosis, and zero caries incidence. ( 6946362 )
1981
41
Periodontosis (Part 1: Review of literature; discussion). ( 7018645 )
1981
42
An analysis and clarification of the status of periodontosis as a disease entity. ( 6928954 )
1980
43
Humoral immunologic responses in idiopathic juvenile periodontitis (periodontosis). ( 6928468 )
1980
44
Serum immunoglobulins in periodontosis patients. ( 6930473 )
1980
45
Immunoglobulins in periodontal tissues. II. Concentrations of immunoglobulins in granulation tissue from pockets of periodontosis and periodontitis patients. ( 6928466 )
1980
46
The distribution of HLA-A and -B antigens in patients and their families with periodontosis. ( 6155463 )
1980
47
Clinical and biochemical assessment of lincomycin with a view to its use in periodontosis treatment. ( 6780434 )
1980
48
Periodontosis of the primary dentition: a case report. ( 6933419 )
1980
49
Periodontosis: semantics or syndrome? An analysis and new model system. ( 296103 )
1979
50
Hyperkeratosis palmoplantaris with periodontosis (Papillon-Lefevre syndrome): report of three cases, two occurring in siblings. ( 155154 )
1979

Variations for Periodontosis

Expression for Periodontosis

Search GEO for disease gene expression data for Periodontosis.

Pathways for Periodontosis

Pathways related to Periodontosis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CD40LG CD79A CTSS CXCL8 ELANE HLA-A
2
Show member pathways
12.4 CXCL8 HLA-A MMP9 TLR4
3 12.38 CD40LG CD79A MPO TNFSF11
4 11.92 CD40LG HLA-A ITGAM SELL
5 11.92 CXCL8 ELANE ITGAM MMP9 MPO
6 11.9 CD40LG HLA-A SELL
7 11.85 CXCL8 MMP9 TLR4
8 11.82 CXCL8 ITGAM MMP9
9 11.77 CD79A ITGAM MPO SELL
10 11.74 CTSS HLA-A ITGAM MPO TLR4
11 11.72 CXCL8 ITGAM TLR4
12 11.68 CXCL8 TLR4 TNFSF11
13 11.65 CD40LG CXCL8 TLR4 TNFSF11
14 11.59 CXCL8 ITGAM TLR4
15
Show member pathways
11.5 CD40LG CXCL8 MMP9
16 11.43 CXCL8 ITGAM TLR4
17 11.36 CD40LG CXCL8 TLR4
18 11.24 ELANE MMP9 SELL
19 11.11 CD40LG MMP9 TLR4
20 10.94 ELANE ITGAM MMP9 MPO
21 10.61 F12 ITGAM KLK4 TLR4

GO Terms for Periodontosis

Cellular components related to Periodontosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 CD40LG CTSS CXCL8 ELANE F12 KLK4
2 cell surface GO:0009986 9.63 CD40LG ELANE HLA-A ITGAM SELL TLR4
3 secretory granule GO:0030141 9.5 ELANE KLK4 MPO
4 external side of plasma membrane GO:0009897 9.35 CD40LG CD79A ITGAM SELL TLR4
5 extracellular space GO:0005615 9.28 CD40LG CTSS CXCL8 ELANE F12 ITGAM

Biological processes related to Periodontosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.89 CTSS ELANE F12 KLK4 MMP9
2 cytokine-mediated signaling pathway GO:0019221 9.76 CXCL8 ITGAM MMP9 TNFSF11
3 immune response GO:0006955 9.73 CD40LG CTSS CXCL8 HLA-A TLR4 TNFSF11
4 leukocyte migration GO:0050900 9.67 ELANE ITGAM MMP9 SELL
5 neutrophil degranulation GO:0043312 9.63 CTSS ELANE ITGAM MMP9 MPO SELL
6 toll-like receptor 4 signaling pathway GO:0034142 9.48 ITGAM TLR4
7 negative regulation of growth of symbiont in host GO:0044130 9.43 ELANE MPO
8 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.4 ELANE TLR4
9 response to yeast GO:0001878 9.32 ELANE MPO
10 extracellular matrix disassembly GO:0022617 9.26 CTSS ELANE KLK4 MMP9
11 response to lipopolysaccharide GO:0032496 9.02 CXCL8 ELANE MPO PTGES TLR4

Molecular functions related to Periodontosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.35 CTSS ELANE F12 KLK4 MMP9
2 serine-type endopeptidase activity GO:0004252 9.02 CTSS ELANE F12 KLK4 MMP9

Sources for Periodontosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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