MCID: PRD003
MIFTS: 40

Periodontosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Periodontosis

MalaCards integrated aliases for Periodontosis:

Name: Periodontosis 12 15 73
Periodontitis, Juvenile 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9893
ICD10 33 K05.4
ICD9CM 35 523.5
MeSH 44 D010520

Summaries for Periodontosis

MalaCards based summary : Periodontosis, also known as periodontitis, juvenile, is related to periodontitis and periodontal disease. An important gene associated with Periodontosis is F12 (Coagulation Factor XII), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ethinyl Estradiol and Moxifloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and whole blood, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 76 Periodontosis is an obsolete term that was used to describe what was once thought to be certain type of... more...

Related Diseases for Periodontosis

Diseases related to Periodontosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 periodontitis 30.8 CXCL8 MMP9 TLR4 TNF TNFSF11
2 periodontal disease 29.7 CXCL8 ELANE MMP9 TLR4 TNF TNFSF11
3 papillon-lefevre syndrome 11.6
4 ehlers-danlos syndrome, periodontal type, 1 11.2
5 periodontal ehlers-danlos syndrome 11.1
6 toxicodendron dermatitis 10.3 CXCL8 SELL
7 vibratory urticaria 10.2 CXCL8 MMP9
8 acute transverse myelitis 10.2 CXCL8 MMP9
9 villonodular synovitis 10.2 MMP9 TNFSF11
10 exudative glomerulonephritis 10.2 CXCL8 TNF
11 chronic venous insufficiency 10.2 ITGAM MMP9 SELL
12 chronic monocytic leukemia 10.2 ITGAM MPO
13 keratosis 10.2
14 pouchitis 10.2 CXCL8 TLR4
15 cryptogenic organizing pneumonia 10.2 CXCL8 MMP9
16 chromoblastomycosis 10.2 HLA-A MMP9
17 cerebral aneurysms 10.2 ELANE MPO
18 tungiasis 10.1 CXCL8 TNF
19 streptococcal toxic-shock syndrome 10.1 CXCL8 TNF
20 pasteurellosis 10.1 ELANE MPO
21 boutonneuse fever 10.1 SELL TLR4
22 cardiac rupture 10.1 CXCL8 ELANE
23 shwartzman phenomenon 10.1 F12 ITGAM TNF
24 fungal keratitis 10.1 MMP9 TLR4
25 trichuriasis 10.1 CXCL8 TNF
26 cardiac sarcoidosis 10.1 CXCL8 TNF
27 farmer's lung 10.1 ELANE TNF
28 microscopic polyangiitis 10.1 MPO TNF
29 scleritis 10.1 MMP9 TNF
30 pustular psoriasis 10.1 ELANE TNF
31 haemophilus influenzae 10.1 CXCL8 TNF
32 trench fever 10.1 TLR4 TNF
33 bronchiectasis 10.1 CXCL8 ELANE MPO
34 bronchopulmonary dysplasia 10.1 CXCL8 ELANE ITGAM SELL
35 bacterial pneumonia 10.1 CXCL8 ELANE TLR4
36 glaucomatocyclitic crisis 10.1 CXCL8 HLA-A TNF
37 opisthorchiasis 10.1 CXCL8 TNF
38 arthus reaction 10.1 ELANE SELL TNF
39 transverse myelitis 10.1 CXCL8 MMP9 TNF
40 monocytic leukemia 10.1 CXCL8 ITGAM TNF
41 tuberculous meningitis 10.1 CXCL8 MMP9 TNF
42 meningitis 10.1 CXCL8 MMP9 TNF
43 dengue hemorrhagic fever 10.1 CXCL8 HLA-A TNF
44 acute pancreatitis 10.1 CXCL8 ELANE MPO
45 retinitis pigmentosa 60 10.1 SELL TNF
46 bronchiolitis obliterans 10.1 CXCL8 MMP9 TNF
47 anca-associated vasculitis 10.1 MPO TNF
48 bacterial meningitis 10.1 CXCL8 MMP9 TNF
49 cytomegalovirus infection 10.1 CXCL8 HLA-A TNF
50 acute respiratory distress syndrome 10.1 CXCL8 ELANE TNF

Comorbidity relations with Periodontosis via Phenotypic Disease Network (PDN):


Dental Caries

Graphical network of the top 20 diseases related to Periodontosis:



Diseases related to Periodontosis

Symptoms & Phenotypes for Periodontosis

MGI Mouse Phenotypes related to Periodontosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CTSS DECR1 ELANE F12 ITGAM KLK4
2 hematopoietic system MP:0005397 10.02 CTSS ELANE ITGAM MMP9 MPO PTGES
3 immune system MP:0005387 9.85 CTSS ELANE ITGAM MMP9 MPO PTGES
4 neoplasm MP:0002006 9.43 ELANE MMP9 SELL TLR4 TNF TNFSF11
5 respiratory system MP:0005388 9.1 CTSS MMP9 SELL TLR4 TNF TNFSF11

Drugs & Therapeutics for Periodontosis

Drugs for Periodontosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
2
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
3
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 26787-78-0 33613
4 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
5
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
6
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
7
Polyestradiol phosphate Approved Phase 4 28014-46-2
8
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
9
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
10
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
11 sodium fluoride Approved Phase 4 7681-49-4
12 Contraceptives, Oral, Combined Phase 4
13 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 Contraceptives, Oral Phase 4
15 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 Estradiol 3-benzoate Phase 4
17 Norgestimate, ethinyl estradiol drug combination Phase 4
18 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
19 Contraceptive Agents Phase 4
20 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
21 Anesthetics Phase 4,Not Applicable
22 Estradiol 17 beta-cypionate Phase 4
23 Topoisomerase Inhibitors Phase 4
24 Nucleic Acid Synthesis Inhibitors Phase 4
25 Fluoroquinolones Phase 4
26 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
27 Chlorhexidine gluconate Phase 4
28 Cariostatic Agents Phase 4
29 Listerine Phase 4
30 Lipid Regulating Agents Phase 4
31 Protective Agents Phase 4
32 Antimetabolites Phase 4
33 Anti-Infective Agents, Local Phase 4
34 Hypolipidemic Agents Phase 4
35 Fluorides Phase 4
36 Anesthetics, Local Phase 4
37
Clarithromycin Approved Phase 2, Phase 3,Phase 3,Not Applicable 81103-11-9 84029
38
Aspirin Approved, Vet_approved Phase 2, Phase 3,Phase 3 50-78-2 2244
39 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
40 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
41 Cyclooxygenase Inhibitors Phase 2, Phase 3,Phase 3
42 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 3
43 Analgesics Phase 2, Phase 3,Phase 3
44 Omega 3 Fatty Acid Phase 2, Phase 3,Phase 3
45 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
46 Antirheumatic Agents Phase 2, Phase 3,Phase 3
47 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
48 Antipyretics Phase 2, Phase 3,Phase 3
49 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3
50 Fibrinolytic Agents Phase 2, Phase 3,Phase 3

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
2 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
3 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
4 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
5 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. Completed NCT03642353 Phase 4 Triclosan;Placebo
6 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
7 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
8 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
9 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
10 Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
11 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093207 Phase 2, Phase 3 Aspirin
12 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093246 Phase 2, Phase 3 Aspirin
13 Doxycycline in the Treatment of Aggressive Periodontitis Completed NCT03727620 Phase 1, Phase 2 amoxicillin plus metronidazole;Doxycycline
14 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
15 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307 Not Applicable
16 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596 Not Applicable
17 B Cell Functions in Periodontitis Unknown status NCT02833285
18 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
19 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533
20 Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis Completed NCT03512938 Not Applicable
21 Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis Completed NCT03412331 Not Applicable
22 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 Completed NCT02927704
23 Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP Completed NCT02817568
24 Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels Completed NCT03034824 Not Applicable
25 Clarithromycin as Adjuvant to Periodontal Debridement Completed NCT02829983 Not Applicable Clarithromycin;Placebo
26 Smoking Influence on Apoptosis in Periodontitis Completed NCT02111005
27 Tissue Alterations in Aggressive and Chronic Periodontitis Completed NCT03625414
28 Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy Completed NCT03142776 Not Applicable systemic clarithromycin
29 Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System Completed NCT02190773
30 Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease Completed NCT03128502
31 Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis Completed NCT03713567 Not Applicable
32 Nitro-oxidative Stress in Periodontitis Completed NCT02127203
33 TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases Completed NCT03558906
34 Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease Completed NCT03527901
35 The Importance of Periostin in Periodontal Health and Disease Completed NCT01180920
36 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3 Completed NCT03078595
37 Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects Completed NCT03399279 Not Applicable
38 Immediate Implant Placement in Aggressive Periodontitis Recruiting NCT03218228 Not Applicable
39 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Recruiting NCT03090282
40 EMD for Treatment of Proximal Class-II Furcation Involvements Recruiting NCT03320135 Not Applicable
41 Mechanisms and Treatment Response of Aggressive Periodontitis in Children Active, not recruiting NCT01330719 Not Applicable
42 Comparison Between Surgical Access and Repeated Applications of APDT Active, not recruiting NCT03140059 Not Applicable
43 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Active, not recruiting NCT03225950
44 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045
45 Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis Not yet recruiting NCT03340012 Not Applicable
46 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Terminated NCT01993368 Not Applicable

Search NIH Clinical Center for Periodontosis

Genetic Tests for Periodontosis

Anatomical Context for Periodontosis

MalaCards organs/tissues related to Periodontosis:

41
Bone, Neutrophil, Whole Blood, Lung, Tongue, Spinal Cord, Monocytes

Publications for Periodontosis

Articles related to Periodontosis:

(show top 50) (show all 143)
# Title Authors Year
1
Xyloglucan Based In Situ Gel of Lidocaine HCl for the Treatment of Periodontosis. ( 27034908 )
2016
2
Periodontosis: A Ninety-Year History: The Legacy of Professor Bernhard Gottlieb. ( 25152003 )
2014
3
An evaluation of statistical methods for the determination of age of death using dental root translucency and periodontosis. ( 20345796 )
2010
4
Long term evaluation of biomaterial application in surgical treatment of periodontosis. ( 19075328 )
2008
5
Polymorphisms within the IL-1 gene cluster: effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. ( 17335371 )
2007
6
Periodontal and hematological characteristics associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. ( 16460255 )
2006
7
Regenerative treatment of serious periodontosis with grafting of cancellous iliac bone and gingival flaps and replanting of patients' teeth. ( 12040204 )
2002
8
Reconstruction of the severely atrophic maxilla in a young adult with periodontosis. ( 10363501 )
1999
9
Hereditary palmoplantar keratoderma with nail changes and periodontosis in a father and son. ( 10071731 )
1999
10
Hypertension medication and periodontosis. ( 9153848 )
1997
11
Juvenile periodontitis (periodontosis)--Part 1. ( 1810674 )
1991
12
Periodontosis case report: 20-year follow-up with laboratory findings. ( 3269551 )
1988
13
Juvenile periodontitis (periodontosis) in a Nigerian teaching hospital. ( 3135397 )
1988
14
Treatment of localized juvenile periodontitis (periodontosis). A review. ( 3543283 )
1987
15
Radiographic evaluation of juvenile periodontitis (periodontosis). ( 3473226 )
1987
16
A syndrome of keratosis palmo-plantaris congenita, pes planus, onychogryphosis, periodontosis, arachnodactyly and a peculiar acro-osteolysis. ( 2943312 )
1986
17
Serum IgA and IgG antibodies to Treponema vincentii and Treponema denticola in adult periodontitis, juvenile periodontitis and periodontally healthy subjects. ( 3464620 )
1986
18
Juvenile periodontitis (periodontosis) and inheritance patterns. ( 3855787 )
1985
19
Hyperkeratosis, periodontosis, and chronic pyogenic infections in a 15-year-old boy. Part One. ( 6742519 )
1984
20
Clinical, microbiological and immunological features associated with the treatment of active periodontosis lesions. ( 6386896 )
1984
21
Hyperkeratosis palmoplantaris with periodontosis. "Papillon-LeFevre syndrome". Report of three cases in the same family. ( 6241143 )
1984
22
Hyperkeratosis, periodontosis, and chronic pyogenic infections in a 15-year-old boy. Part Two. ( 6742526 )
1984
23
Periodontosis - a sixteen year case report. ( 6964151 )
1982
24
Juvenile periodontitis (periodontosis). Literature review and case reports. ( 6960334 )
1982
25
Early diagnosis and successful management of periodontosis. ( 7050211 )
1982
26
The prevalence of juvenile periodontitis ("periodontosis") in a dental school patient population. ( 6976982 )
1982
27
Autogenous transplants in the treatment of juvenile periodontitis (periodontosis). ( 6957470 )
1982
28
Clinical evaluation of localized periodontosis defects treated with freeze-dried bone allografts combined with local and systemic tetracyclines. ( 6757167 )
1982
29
Bacterial interference in the oral ecology of Actinobacillus actinomycetemcomitans and its relationship to human periodontosis. ( 6951532 )
1982
30
Juvenile periodontitis/periodontosis: historical overview and update. ( 6751882 )
1982
31
Gingival crevice neutrophil function in periodontosis. ( 6752372 )
1982
32
Periodontosis. Part II: Diagnosis and classification. ( 7026005 )
1981
33
An update on periodontosis. ( 6944157 )
1981
34
A rational approach to the management of periodontosis. ( 6954140 )
1981
35
Periodontosis. Part III: Barbados study. ( 6115707 )
1981
36
Immunologic study of human periodontosis (juvenile periodontitis). ( 6782228 )
1981
37
Periodontosis. Case, analysis and treatment. ( 7047428 )
1981
38
Periodontosis - a positive prognosis. ( 6954141 )
1981
39
IgG and IgG subclasses in human periodontosis (juvenile periodontitis). Serum concentrations. ( 6785410 )
1981
40
Tooth transplantation--a treatment modality in periodontosis. ( 7026004 )
1981
41
A comparison of identical twins in relation to three dental anomalies: multiple supernumerary teeth, juvenile periodontosis, and zero caries incidence. ( 6946362 )
1981
42
Periodontosis (Part 1: Review of literature; discussion). ( 7018645 )
1981
43
An analysis and clarification of the status of periodontosis as a disease entity. ( 6928954 )
1980
44
Humoral immunologic responses in idiopathic juvenile periodontitis (periodontosis). ( 6928468 )
1980
45
Serum immunoglobulins in periodontosis patients. ( 6930473 )
1980
46
Immunoglobulins in periodontal tissues. II. Concentrations of immunoglobulins in granulation tissue from pockets of periodontosis and periodontitis patients. ( 6928466 )
1980
47
The distribution of HLA-A and -B antigens in patients and their families with periodontosis. ( 6155463 )
1980
48
Clinical and biochemical assessment of lincomycin with a view to its use in periodontosis treatment. ( 6780434 )
1980
49
Periodontosis of the primary dentition: a case report. ( 6933419 )
1980
50
Periodontosis: treatment results in 15-year-old girl. ( 6935270 )
1980

Variations for Periodontosis

Expression for Periodontosis

Search GEO for disease gene expression data for Periodontosis.

Pathways for Periodontosis

Pathways related to Periodontosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 CTSS CXCL8 ELANE HLA-A ITGAM MMP9
2
Show member pathways
13.2 CXCL8 HLA-A ITGAM MMP9 TNF TNFSF11
3
Show member pathways
12.91 CXCL8 HLA-A MMP9 TLR4 TNF
4 12.12 CTSS ITGAM TLR4 TNF
5
Show member pathways
12.08 CTSS CXCL8 TLR4 TNF
6 11.99 CXCL8 ELANE ITGAM MMP9 MPO
7 11.97 HLA-A ITGAM SELL
8
Show member pathways
11.93 ITGAM MMP9 TLR4 TNF
9 11.89 CXCL8 MMP9 TLR4 TNF
10 11.86 ITGAM MPO SELL TNF
11 11.84 CXCL8 ITGAM MMP9 TNF
12
Show member pathways
11.78 ELANE MMP9 TNF
13 11.74 CXCL8 ITGAM TLR4 TNF
14 11.74 CTSS HLA-A ITGAM MPO TLR4
15 11.71 CXCL8 TLR4 TNF TNFSF11
16 11.66 CXCL8 TLR4 TNF TNFSF11
17 11.64 ITGAM SELL TNF
18 11.57 CXCL8 MMP9 TNF
19
Show member pathways
11.56 CXCL8 MMP9 TNF
20 11.55 CXCL8 ITGAM TLR4 TNF
21 11.44 CXCL8 TLR4 TNF
22 11.31 ELANE MMP9 SELL
23 11.3 CXCL8 ITGAM TLR4 TNF
24 11.03 ELANE ITGAM MMP9 MPO TNF
25 10.91 CXCL8 TNF
26 10.82 MPO TNF
27 10.7 F12 ITGAM KLK4 TLR4 TNF

GO Terms for Periodontosis

Cellular components related to Periodontosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 CTSS CXCL8 ELANE F12 KLK4 MMP9
2 external side of plasma membrane GO:0009897 9.62 ITGAM SELL TLR4 TNF
3 secretory granule GO:0030141 9.43 ELANE KLK4 MPO
4 cell surface GO:0009986 9.43 ELANE HLA-A ITGAM SELL TLR4 TNF
5 extracellular space GO:0005615 9.28 CTSS CXCL8 ELANE F12 ITGAM MMP9

Biological processes related to Periodontosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.93 CTSS ELANE F12 KLK4 MMP9
2 immune response GO:0006955 9.85 CTSS CXCL8 HLA-A TLR4 TNF TNFSF11
3 defense response to bacterium GO:0042742 9.8 ELANE MPO TLR4 TNF
4 cytokine-mediated signaling pathway GO:0019221 9.8 CXCL8 ITGAM MMP9 TNF TNFSF11
5 neutrophil degranulation GO:0043312 9.8 CTSS ELANE ITGAM MMP9 MPO SELL
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.78 TLR4 TNF TNFSF11
7 defense response GO:0006952 9.77 CXCL8 MPO TNF
8 response to lipopolysaccharide GO:0032496 9.73 ELANE MPO PTGES TLR4
9 positive regulation of JNK cascade GO:0046330 9.69 TLR4 TNF TNFSF11
10 positive regulation of MAP kinase activity GO:0043406 9.65 ELANE TNF TNFSF11
11 positive regulation of osteoclast differentiation GO:0045672 9.59 TNF TNFSF11
12 positive regulation of chemokine production GO:0032722 9.58 TLR4 TNF
13 microglial cell activation GO:0001774 9.58 ITGAM TNF
14 embryonic digestive tract development GO:0048566 9.57 CXCL8 TNF
15 leukocyte tethering or rolling GO:0050901 9.56 SELL TNF
16 toll-like receptor 4 signaling pathway GO:0034142 9.55 ITGAM TLR4
17 leukocyte migration GO:0050900 9.55 ELANE ITGAM MMP9 SELL TNF
18 regulation of osteoclast differentiation GO:0045670 9.52 TNF TNFSF11
19 response to yeast GO:0001878 9.46 ELANE MPO
20 negative regulation of growth of symbiont in host GO:0044130 9.43 ELANE MPO TNF
21 extracellular matrix disassembly GO:0022617 9.26 CTSS ELANE KLK4 MMP9
22 positive regulation of interleukin-8 biosynthetic process GO:0045416 8.8 ELANE TLR4 TNF

Molecular functions related to Periodontosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.35 CTSS ELANE F12 KLK4 MMP9
2 protease binding GO:0002020 9.33 ELANE SELL TNF
3 serine-type endopeptidase activity GO:0004252 9.02 CTSS ELANE F12 KLK4 MMP9

Sources for Periodontosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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