MCID: PRS016
MIFTS: 37

Periosteal Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Periosteal Chondrosarcoma

MalaCards integrated aliases for Periosteal Chondrosarcoma:

Name: Periosteal Chondrosarcoma 12 15
Juxtacortical Chondrosarcoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5859
UMLS 73 C0334549

Summaries for Periosteal Chondrosarcoma

MalaCards based summary : Periosteal Chondrosarcoma, also known as juxtacortical chondrosarcoma, is related to chondrosarcoma and meninges hemangiopericytoma, and has symptoms including pain An important gene associated with Periosteal Chondrosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are Human cytomegalovirus infection and PI3K-Akt signaling pathway. Affiliated tissues include bone, lung and skin, and related phenotypes are cellular and growth/size/body region

Related Diseases for Periosteal Chondrosarcoma

Diseases related to Periosteal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.6 EXT1 IDH1 IDH2 NCOA2 PTHLH
2 meninges hemangiopericytoma 10.2 HEY1 NCOA2
3 enchondroma 10.2 IDH1 IDH2
4 mesenchymal chondrosarcoma 10.2 HEY1 NCOA2
5 interval angle-closure glaucoma 10.2 IDH1 IDH2
6 adult oligodendroglioma 10.2 IDH1 IDH2
7 intracranial chondrosarcoma 10.2 IDH1 IDH2
8 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
9 chondroblastic osteosarcoma 10.2 IDH1 IDH2
10 intraductal papilloma 10.2 IDH1 IDH2
11 pilocytic astrocytoma of cerebellum 10.2 IDH1 IDH2
12 spindle cell hemangioma 10.2 IDH1 IDH2
13 glioma susceptibility 1 10.2 IDH1 IDH2
14 adult astrocytic tumour 10.2 IDH1 IDH2
15 fibrillary astrocytoma 10.2 IDH1 IDH2
16 diffuse infiltrative lymphocytosis syndrome 10.1 IDH1 IDH2
17 drug-induced mental disorder 10.1 IDH1 IDH2
18 drug psychosis 10.1 IDH1 IDH2
19 lymphoepithelioma-like thymic carcinoma 10.1 CDKN2A IDH1
20 undifferentiated pleomorphic sarcoma 10.1 IDH1 IDH2
21 2-hydroxyglutaric aciduria 10.1 IDH1 IDH2
22 anaplastic oligodendroglioma 10.1 CDKN2A IDH2
23 juxtacortical chondroma 10.1 EXT1 PTHLH
24 d-2-hydroxyglutaric aciduria 1 10.1 IDH1 IDH2
25 gallbladder adenoma 10.1 CDKN2A RB1
26 bile duct adenocarcinoma 10.1 IDH1 IDH2
27 childhood oligodendroglioma 10.1 IDH1 MDM2
28 suppressor of tumorigenicity 3 10.1 CDKN2A RB1
29 gliomatosis cerebri 10.1 IDH1 MDM2
30 multiple enchondromatosis, maffucci type 10.1 EXT1 IDH1 IDH2
31 adult medulloblastoma 10.0 IDH1 MDM2
32 pleomorphic liposarcoma 10.0 CDKN2A MDM2
33 osteochondroma 10.0 EXT1 PTHLH
34 chondroma 10.0
35 central nervous system cancer 10.0 CDKN2A IDH1 IDH2
36 oligodendroglioma 10.0 CDKN2A IDH1 IDH2
37 chondromyxoid fibroma 10.0 CDKN2A PTHLH
38 cornea cancer 10.0 CDK4 CDKN2A
39 ring chromosome 7 9.9 CDK4 MDM2
40 undifferentiated embryonal sarcoma of the liver 9.9 CDK4 MDM2
41 embryonal sarcoma 9.9 CDK4 MDM2
42 cellular myxoid liposarcoma 9.9 CDK4 MDM2
43 inflammatory mfh 9.9 CDK4 MDM2
44 lipoblastoma 9.9 CDK4 MDM2
45 malignant fibrous histiocytoma of bone 9.9 CDK4 MDM2
46 bone osteosarcoma 9.9 CDK4 MDM2
47 li-fraumeni syndrome 9.9 CDKN2A IDH1 MDM2
48 mixed liposarcoma 9.9 CDK4 MDM2
49 chondroid lipoma 9.9 CDK4 MDM2
50 brain stem glioma 9.9 IDH1 IDH2

Graphical network of the top 20 diseases related to Periosteal Chondrosarcoma:



Diseases related to Periosteal Chondrosarcoma

Symptoms & Phenotypes for Periosteal Chondrosarcoma

UMLS symptoms related to Periosteal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Periosteal Chondrosarcoma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 CDK4 CDKN2A EXT1 HEY1 MDM2 NCOA2
2 growth/size/body region MP:0005378 10.18 CDK4 CDKN2A EXT1 HEY1 IDH1 MDM2
3 behavior/neurological MP:0005386 10.14 CDK4 CDKN2A EXT1 MDM2 NCOA2 PTHLH
4 cardiovascular system MP:0005385 10.13 CDK4 CDKN2A HEY1 IDH2 MDM2 PTHLH
5 embryo MP:0005380 10.09 CDK4 CDKN2A EXT1 HEY1 MDM2 NCOA2
6 mortality/aging MP:0010768 10.06 CDK4 CDKN2A EXT1 HEY1 IDH1 MDM2
7 immune system MP:0005387 10.05 CDK4 CDKN2A IDH1 MDM2 NCOA2 PTHLH
8 integument MP:0010771 10.04 CDK4 CDKN2A EXT1 MDM2 NCOA2 PTHLH
9 digestive/alimentary MP:0005381 10.03 CDK4 CDKN2A EXT1 MDM2 PTHLH RB1
10 endocrine/exocrine gland MP:0005379 10.01 CDK4 CDKN2A MDM2 NCOA2 PTHLH RB1
11 craniofacial MP:0005382 9.97 EXT1 HEY1 MDM2 PTHLH RB1
12 neoplasm MP:0002006 9.95 CDK4 CDKN2A EXT1 IDH2 MDM2 PTHLH
13 nervous system MP:0003631 9.91 CDK4 CDKN2A EXT1 HEY1 MDM2 PTHLH
14 liver/biliary system MP:0005370 9.88 CDK4 CDKN2A MDM2 PTHLH RB1
15 muscle MP:0005369 9.83 CDK4 CDKN2A HEY1 MDM2 RB1
16 normal MP:0002873 9.73 CDK4 EXT1 HEY1 MDM2 PTHLH RB1
17 no phenotypic analysis MP:0003012 9.72 CDKN2A EXT1 MDM2 NCOA2 RB1
18 pigmentation MP:0001186 9.46 CDK4 CDKN2A MDM2 RB1
19 reproductive system MP:0005389 9.43 CDK4 CDKN2A MDM2 NCOA2 PTHLH RB1
20 skeleton MP:0005390 9.1 CDKN2A EXT1 IDH1 MDM2 PTHLH RB1

Drugs & Therapeutics for Periosteal Chondrosarcoma

Search Clinical Trials , NIH Clinical Center for Periosteal Chondrosarcoma

Genetic Tests for Periosteal Chondrosarcoma

Anatomical Context for Periosteal Chondrosarcoma

MalaCards organs/tissues related to Periosteal Chondrosarcoma:

41
Bone, Lung, Skin, Brain, Liver, Cerebellum, Myeloid

Publications for Periosteal Chondrosarcoma

Articles related to Periosteal Chondrosarcoma:

(show all 20)
# Title Authors Year
1
Diagnosis and Outcome of Periosteal Chondrosarcoma in Two Cats. ( 27487347 )
2016
2
Periosteal chondrosarcoma: a histopathological and molecular analysis of a rare chondrosarcoma subtype. ( 25648524 )
2015
3
Bony metastases following complete resection of periosteal chondrosarcoma. ( 25889026 )
2015
4
Usefulness of PET/CT for diagnosis of periosteal chondrosarcoma of the femur: A case report. ( 24932240 )
2014
5
The presentation, treatment and outcome of periosteal chondrosarcoma in the Netherlands. ( 24891585 )
2014
6
Periosteal chondrosarcoma of metacarpal bone: Report of a rare entity. ( 23289049 )
2012
7
Periosteal chondrosarcoma of the foot: a case report. ( 20576447 )
2010
8
Periosteal chondrosarcoma. ( 19098166 )
2009
9
Periosteal chondrosarcoma with microscopic cortical invasion. ( 18696199 )
2008
10
Survivorship analysis in patients with periosteal chondrosarcoma. ( 16826117 )
2006
11
Periosteal chondrosarcoma in a 9-year-old girl with osteochondromatosis. ( 15723209 )
2005
12
Periosteal chondrosarcoma. ( 12938935 )
2003
13
Periosteal chondrosarcoma. ( 12195911 )
2002
14
DNA ploidy alterations detected during dedifferentiation of periosteal chondrosarcoma. ( 10472345 )
1999
15
Periosteal chondrosarcoma: a case report and review of the literature. ( 9111097 )
1997
16
Periosteal chondrosarcoma invading the medullary cavity. ( 9229422 )
1997
17
Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. ( 8685228 )
1996
18
MR appearance of periosteal chondrosarcoma of the foot. ( 7822524 )
1995
19
Periosteal chondroma and periosteal chondrosarcoma. ( 4051099 )
1985
20
Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities. ( 7096408 )
1982

Variations for Periosteal Chondrosarcoma

Expression for Periosteal Chondrosarcoma

Search GEO for disease gene expression data for Periosteal Chondrosarcoma.

Pathways for Periosteal Chondrosarcoma

Pathways related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 CDK4 CDKN2A MDM2 RB1
2
Show member pathways
12.79 CDK4 HEY1 MDM2 RB1
3
Show member pathways
12.67 CDK4 CDKN2A MDM2 RB1
4
Show member pathways
12.55 CDK4 CDKN2A MDM2 RB1
5 12.55 CDK4 CDKN2A HEY1 MDM2 RB1
6
Show member pathways
12.53 CDK4 CDKN2A HEY1 RB1
7
Show member pathways
12.36 CDK4 CDKN2A MDM2 RB1
8 12.27 CDK4 CDKN2A MDM2 RB1
9
Show member pathways
12.24 CDK4 CDKN2A RB1
10 12.23 CDK4 CDKN2A RB1
11
Show member pathways
12.16 CDK4 CDKN2A RB1
12
Show member pathways
12.15 CDK4 CDKN2A MDM2 RB1
13 12.12 CDK4 CDKN2A MDM2 RB1
14 12.11 CDK4 MDM2 RB1
15
Show member pathways
12.06 CDK4 MDM2 RB1
16
Show member pathways
12.04 CDK4 CDKN2A RB1
17
Show member pathways
12.02 CDK4 MDM2 RB1
18 12.01 CDK4 CDKN2A MDM2 RB1
19 11.95 CDK4 MDM2 RB1
20 11.86 CDKN2A MDM2 RB1
21 11.83 CDK4 CDKN2A MDM2 RB1
22 11.75 CDKN2A MDM2 RB1
23 11.66 MDM2 NCOA2 RB1
24 11.63 CDK4 MDM2 RB1
25 11.51 CDKN2A MDM2 RB1
26 11.31 CDK4 MDM2
27 11.3 CDK4 CDKN2A MDM2 RB1
28 11.21 CDK4 RB1
29 11.21 CDK4 MDM2 RB1
30 11.03 NCOA2 RB1
31 10.94 CDK4 CDKN2A MDM2
32
Show member pathways
10.93 CDKN2A MDM2
33 10.79 CDK4 CDKN2A MDM2 RB1
34
Show member pathways
10.67 IDH1 IDH2
35 10.67 CDKN2A MDM2 RB1

GO Terms for Periosteal Chondrosarcoma

Cellular components related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.17 CDK4 CDKN2A HEY1 MDM2 NCOA2 PTHLH

Biological processes related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 G1/S transition of mitotic cell cycle GO:0000082 9.61 CDK4 CDKN2A RB1
2 protein destabilization GO:0031648 9.56 CDKN2A MDM2
3 protein sumoylation GO:0016925 9.55 CDKN2A MDM2
4 negative regulation of transcription, DNA-templated GO:0045892 9.55 CDKN2A HEY1 MDM2 NCOA2 RB1
5 tricarboxylic acid cycle GO:0006099 9.54 IDH1 IDH2
6 response to steroid hormone GO:0048545 9.52 IDH1 MDM2
7 negative regulation of cell cycle arrest GO:0071157 9.51 CDK4 MDM2
8 2-oxoglutarate metabolic process GO:0006103 9.49 IDH1 IDH2
9 endocardial cushion morphogenesis GO:0003203 9.48 HEY1 MDM2
10 cardiac septum morphogenesis GO:0060411 9.46 HEY1 MDM2
11 amyloid fibril formation GO:1990000 9.4 CDKN2A MDM2
12 NADP metabolic process GO:0006739 9.37 IDH1 IDH2
13 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.32 CDK4 CDKN2A
14 isocitrate metabolic process GO:0006102 9.26 IDH1 IDH2
15 regulation of gene expression GO:0010468 9.26 CDK4 MDM2 NCOA2 PTHLH
16 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.56 CDKN2A HEY1 NCOA2 RB1
2 NAD binding GO:0051287 9.4 IDH1 IDH2
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.37 IDH1 IDH2
4 disordered domain specific binding GO:0097718 9.33 CDKN2A MDM2 RB1
5 SUMO transferase activity GO:0019789 9.32 CDKN2A MDM2
6 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
7 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Periosteal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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