Aliases & Classifications for Periosteal Chondrosarcoma

MalaCards integrated aliases for Periosteal Chondrosarcoma:

Name: Periosteal Chondrosarcoma 12 15
Juxtacortical Chondrosarcoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5859

Summaries for Periosteal Chondrosarcoma

MalaCards based summary : Periosteal Chondrosarcoma, also known as juxtacortical chondrosarcoma, is related to enchondroma and chondrosarcoma, and has symptoms including pain An important gene associated with Periosteal Chondrosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. Affiliated tissues include bone, and related phenotypes are cellular and growth/size/body region

Related Diseases for Periosteal Chondrosarcoma

Diseases related to Periosteal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 enchondroma 30.8 IDH1 IDH2
2 chondrosarcoma 30.0 EXT1 IDH1 IDH2 NCOA2 PTHLH
3 meninges hemangiopericytoma 10.8 HEY1 NCOA2
4 interval angle-closure glaucoma 10.7 IDH1 IDH2
5 adult oligodendroglioma 10.7 IDH1 IDH2
6 intracranial chondrosarcoma 10.7 IDH1 IDH2
7 mesenchymal chondrosarcoma 10.7 HEY1 NCOA2
8 cytogenetically normal acute myeloid leukemia 10.6 IDH1 IDH2
9 chondroblastic osteosarcoma 10.6 IDH1 IDH2
10 intraductal papilloma 10.6 IDH1 IDH2
11 pilocytic astrocytoma of cerebellum 10.6 IDH1 IDH2
12 spindle cell hemangioma 10.6 IDH1 IDH2
13 glioma susceptibility 1 10.6 IDH1 IDH2
14 adult astrocytic tumour 10.6 IDH1 IDH2
15 fibrillary astrocytoma 10.6 IDH1 IDH2
16 undifferentiated pleomorphic sarcoma 10.6 IDH1 IDH2
17 periostitis 10.5
18 drug-induced mental disorder 10.5 IDH1 IDH2
19 drug psychosis 10.5 IDH1 IDH2
20 diffuse infiltrative lymphocytosis syndrome 10.4 IDH1 IDH2
21 2-hydroxyglutaric aciduria 10.4 IDH1 IDH2
22 brain stem glioma 10.4 IDH1 IDH2
23 breast papillary carcinoma 10.4 IDH1 IDH2
24 childhood oligodendroglioma 10.4 IDH1 MDM2
25 d-2-hydroxyglutaric aciduria 1 10.4 IDH1 IDH2
26 gliomatosis cerebri 10.3 IDH1 MDM2
27 multiple enchondromatosis, maffucci type 10.3 EXT1 IDH1 IDH2
28 clear cell adenoma 10.3 CTNNB1 PTHLH
29 conventional fibrosarcoma 10.2 CTNNB1 MDM2
30 adult medulloblastoma 10.1 IDH1 MDM2
31 ring chromosome 7 10.1 CDK4 MDM2
32 bile duct adenocarcinoma 10.1 IDH1 IDH2
33 undifferentiated embryonal sarcoma of the liver 10.1 CDK4 MDM2
34 extraosseous osteosarcoma 10.1 CDK4 MDM2
35 inflammatory mfh 10.1 CDK4 MDM2
36 bone osteosarcoma 10.1 CDK4 MDM2
37 lipoblastoma 10.1 CDK4 MDM2
38 mixed liposarcoma 10.1 CDK4 MDM2
39 malignant fibrous histiocytoma of bone 10.1 CDK4 MDM2
40 anaplastic oligodendroglioma 10.0 CDKN2A IDH2
41 spindle cell liposarcoma 10.0 CDK4 MDM2
42 chondroid lipoma 10.0 CDK4 MDM2
43 bladder urothelial carcinoma 10.0 CTNNB1 IDH1 RB1
44 small cell sarcoma 10.0 CDK4 MDM2
45 juxtacortical chondroma 10.0 CTNNB1 EXT1 PTHLH
46 infiltrating lipoma 10.0 CDK4 MDM2
47 pleomorphic lipoma 9.9 CDK4 MDM2
48 suppressor of tumorigenicity 3 9.9 CDKN2A RB1
49 gliosarcoma 9.9 CDK4 IDH1 RB1
50 osteochondroma 9.9 EXT1 PTHLH

Graphical network of the top 20 diseases related to Periosteal Chondrosarcoma:



Diseases related to Periosteal Chondrosarcoma

Symptoms & Phenotypes for Periosteal Chondrosarcoma

UMLS symptoms related to Periosteal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Periosteal Chondrosarcoma:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.24 EXT1 MDM2 HEY1 NCOA2 PTHLH RB1
2 growth/size/body region MP:0005378 10.24 EXT1 MDM2 HEY1 NCOA2 IDH1 PTHLH
3 behavior/neurological MP:0005386 10.2 EXT1 MDM2 NCOA2 RB1 PTHLH CTNNB1
4 cardiovascular system MP:0005385 10.19 IDH2 MDM2 HEY1 PTHLH RB1 CDKN2A
5 embryo MP:0005380 10.16 EXT1 MDM2 HEY1 NCOA2 RB1 CDKN2A
6 immune system MP:0005387 10.13 MDM2 IDH1 NCOA2 RB1 PTHLH CTNNB1
7 mortality/aging MP:0010768 10.13 IDH1 EXT1 MDM2 HEY1 RB1 PTHLH
8 digestive/alimentary MP:0005381 10.11 EXT1 MDM2 PTHLH RB1 CDKN2A CDK4
9 integument MP:0010771 10.11 EXT1 MDM2 NCOA2 PTHLH RB1 CDKN2A
10 endocrine/exocrine gland MP:0005379 10.09 MDM2 NCOA2 RB1 PTHLH CTNNB1 CDKN2A
11 craniofacial MP:0005382 10.05 EXT1 MDM2 HEY1 PTHLH RB1 CTNNB1
12 nervous system MP:0003631 10.01 EXT1 MDM2 HEY1 RB1 PTHLH CTNNB1
13 neoplasm MP:0002006 9.98 IDH2 EXT1 MDM2 RB1 CDK4 CTNNB1
14 muscle MP:0005369 9.93 MDM2 HEY1 RB1 CTNNB1 CDKN2A CDK4
15 limbs/digits/tail MP:0005371 9.89 EXT1 MDM2 RB1 PTHLH CTNNB1
16 no phenotypic analysis MP:0003012 9.85 EXT1 MDM2 NCOA2 RB1 CDKN2A CTNNB1
17 normal MP:0002873 9.8 EXT1 MDM2 HEY1 RB1 CTNNB1 CDK4
18 reproductive system MP:0005389 9.7 NCOA2 MDM2 RB1 PTHLH CDKN2A CDK4
19 pigmentation MP:0001186 9.65 MDM2 RB1 CDKN2A CDK4 CTNNB1
20 skeleton MP:0005390 9.5 EXT1 MDM2 IDH1 RB1 PTHLH CDKN2A
21 vision/eye MP:0005391 9.1 EXT1 RB1 PTHLH CTNNB1 CDKN2A CDK4

Drugs & Therapeutics for Periosteal Chondrosarcoma

Search Clinical Trials , NIH Clinical Center for Periosteal Chondrosarcoma

Genetic Tests for Periosteal Chondrosarcoma

Anatomical Context for Periosteal Chondrosarcoma

MalaCards organs/tissues related to Periosteal Chondrosarcoma:

41
Bone

Publications for Periosteal Chondrosarcoma

Articles related to Periosteal Chondrosarcoma:

(show all 21)
# Title Authors Year
1
Diagnosis and Outcome of Periosteal Chondrosarcoma in Two Cats. ( 27487347 )
2016
2
Periosteal chondrosarcoma: a histopathological and molecular analysis of a rare chondrosarcoma subtype. ( 25648524 )
2015
3
Bony metastases following complete resection of periosteal chondrosarcoma. ( 25889026 )
2015
4
Usefulness of PET/CT for diagnosis of periosteal chondrosarcoma of the femur: A case report. ( 24932240 )
2014
5
The presentation, treatment and outcome of periosteal chondrosarcoma in the Netherlands. ( 24891585 )
2014
6
IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas. ( 22074484 )
2012
7
Periosteal chondrosarcoma of metacarpal bone: Report of a rare entity. ( 23289049 )
2012
8
Periosteal chondrosarcoma of the foot: a case report. ( 20576447 )
2010
9
Periosteal chondrosarcoma. ( 19098166 )
2009
10
Periosteal chondrosarcoma with microscopic cortical invasion. ( 18696199 )
2008
11
Survivorship analysis in patients with periosteal chondrosarcoma. ( 16826117 )
2006
12
Periosteal chondrosarcoma in a 9-year-old girl with osteochondromatosis. ( 15723209 )
2005
13
Periosteal chondrosarcoma. ( 12938935 )
2003
14
Periosteal chondrosarcoma. ( 12195911 )
2002
15
DNA ploidy alterations detected during dedifferentiation of periosteal chondrosarcoma. ( 10472345 )
1999
16
Periosteal chondrosarcoma: a case report and review of the literature. ( 9111097 )
1997
17
Periosteal chondrosarcoma invading the medullary cavity. ( 9229422 )
1997
18
Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. ( 8685228 )
1996
19
MR appearance of periosteal chondrosarcoma of the foot. ( 7822524 )
1995
20
Periosteal chondroma and periosteal chondrosarcoma. ( 4051099 )
1985
21
Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities. ( 7096408 )
1982

Variations for Periosteal Chondrosarcoma

Expression for Periosteal Chondrosarcoma

Search GEO for disease gene expression data for Periosteal Chondrosarcoma.

Pathways for Periosteal Chondrosarcoma

Pathways related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 CDK4 CTNNB1 HEY1 MDM2 RB1
2
Show member pathways
12.68 CDK4 CDKN2A CTNNB1 MDM2 RB1
3
Show member pathways
12.6 CDK4 CDKN2A MDM2 RB1
4
Show member pathways
12.54 CDK4 CDKN2A CTNNB1 HEY1 RB1
5
Show member pathways
12.41 CDK4 CDKN2A MDM2 RB1
6 12.35 CDK4 CDKN2A MDM2 RB1
7 12.35 CDK4 CDKN2A CTNNB1 HEY1 MDM2 RB1
8 12.27 CDK4 CDKN2A CTNNB1 RB1
9
Show member pathways
12.22 CDK4 CDKN2A MDM2 RB1
10
Show member pathways
12.18 CDK4 CDKN2A RB1
11 12.18 CDK4 CDKN2A MDM2 RB1
12 12.11 CDK4 CDKN2A MDM2 RB1
13
Show member pathways
12.1 CDK4 MDM2 RB1
14
Show member pathways
12.07 CDK4 CDKN2A RB1
15
Show member pathways
11.97 CTNNB1 MDM2 NCOA2
16 11.94 CDK4 CDKN2A MDM2 RB1
17 11.92 CTNNB1 NCOA2 RB1
18 11.89 CDK4 CTNNB1 MDM2 RB1
19 11.86 CTNNB1 MDM2 NCOA2
20 11.85 CDKN2A CTNNB1 MDM2
21 11.84 CDKN2A CTNNB1 MDM2 RB1
22 11.8 CDKN2A MDM2 RB1
23 11.7 CDK4 MDM2 RB1
24 11.52 CTNNB1 MDM2 NCOA2 RB1
25 11.33 CDK4 MDM2 RB1
26 11.23 CDK4 RB1
27 11.12 CDK4 CDKN2A MDM2 RB1
28 11.07 CDK4 CDKN2A CTNNB1 MDM2 RB1
29 11.05 CDK4 CDKN2A MDM2
30 11.04 NCOA2 RB1
31
Show member pathways
10.98 CDKN2A MDM2
32 10.84 CDKN2A MDM2 RB1
33
Show member pathways
10.72 IDH1 IDH2

GO Terms for Periosteal Chondrosarcoma

Cellular components related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.23 CDK4 CDKN2A CTNNB1 HEY1 MDM2 NCOA2
2 transcription factor complex GO:0005667 9.13 CDK4 CTNNB1 RB1

Biological processes related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.96 CDKN2A CTNNB1 HEY1 NCOA2 RB1
2 positive regulation of cell proliferation GO:0008284 9.87 CDK4 CTNNB1 MDM2 PTHLH
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.83 CTNNB1 HEY1 MDM2 NCOA2 RB1
4 negative regulation of cell proliferation GO:0008285 9.8 CDKN2A CTNNB1 PTHLH RB1
5 negative regulation of gene expression GO:0010629 9.77 CTNNB1 MDM2 RB1
6 skeletal system development GO:0001501 9.7 CTNNB1 EXT1 PTHLH
7 G1/S transition of mitotic cell cycle GO:0000082 9.63 CDK4 CDKN2A RB1
8 response to steroid hormone GO:0048545 9.58 IDH1 MDM2
9 tricarboxylic acid cycle GO:0006099 9.58 IDH1 IDH2
10 regulation of gene expression GO:0010468 9.56 CDK4 CTNNB1 MDM2 PTHLH
11 negative regulation of cell cycle arrest GO:0071157 9.55 CDK4 MDM2
12 2-oxoglutarate metabolic process GO:0006103 9.54 IDH1 IDH2
13 negative regulation of chondrocyte differentiation GO:0032331 9.51 CTNNB1 PTHLH
14 endocardial cushion morphogenesis GO:0003203 9.48 HEY1 MDM2
15 cardiac septum morphogenesis GO:0060411 9.4 HEY1 MDM2
16 amyloid fibril formation GO:1990000 9.37 CDKN2A MDM2
17 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.32 CDK4 CDKN2A
18 isocitrate metabolic process GO:0006102 9.16 IDH1 IDH2
19 negative regulation of transcription, DNA-templated GO:0045892 9.1 CDKN2A CTNNB1 HEY1 MDM2 NCOA2 RB1
20 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2

Molecular functions related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear hormone receptor binding GO:0035257 9.37 CTNNB1 NCOA2
2 transcription factor binding GO:0008134 9.35 CDKN2A CTNNB1 HEY1 NCOA2 RB1
3 SUMO transferase activity GO:0019789 9.32 CDKN2A MDM2
4 isocitrate dehydrogenase activity GO:0004448 9.26 IDH1 IDH2
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.16 IDH1 IDH2
6 disordered domain specific binding GO:0097718 8.92 CDKN2A CTNNB1 MDM2 RB1

Sources for Periosteal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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