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Periosteal Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Periosteal Osteogenic Sarcoma

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MalaCards integrated aliases for Periosteal Osteogenic Sarcoma:

Name: Periosteal Osteogenic Sarcoma 12 15
Periosteal Osteosarcoma 12 70
Parosteal Osteosarcoma 70

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6489
NCIt 50 C8970
SNOMED-CT 67 91242000
UMLS 70 C0206642 C1377843
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Summaries for Periosteal Osteogenic Sarcoma

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MalaCards based summary : Periosteal Osteogenic Sarcoma, also known as periosteal osteosarcoma, is related to juxtacortical osteosarcoma and ossifying fibroma. An important gene associated with Periosteal Osteogenic Sarcoma is OR7C1 (Olfactory Receptor Family 7 Subfamily C Member 1), and among its related pathways/superpathways are DNA Damage and Integrated Cancer Pathway. Affiliated tissues include bone marrow and lymph node, and related phenotypes are Increased BBC3 mRNA expression and endocrine/exocrine gland

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Related Diseases for Periosteal Osteogenic Sarcoma

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Diseases related to Periosteal Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 juxtacortical osteosarcoma 30.0 SATB2 MDM2 GNAS
2 ossifying fibroma 29.9 MDM2 GNAS
3 osteogenic sarcoma 10.4
4 chondrosarcoma 10.3
5 chondroblastic osteosarcoma 10.3
6 periosteal chondrosarcoma 10.3
7 extraosseous osteosarcoma 10.2 SATB2 MDM2
8 myositis ossificans 10.1 SATB2 MDM2
9 conventional central osteosarcoma 10.1 SATB2 MDM2
10 appendiceal neoplasm 10.1 SATB2 GNAS
11 appendix adenocarcinoma 10.1 SATB2 GNAS
12 ring chromosome 7 10.1 TP53 MDM2
13 ring chromosome 10.1 TP53 MDM2
14 actinic cheilitis 10.1 TP53 MDM2
15 cheilitis 10.1 TP53 MDM2
16 esophagus verrucous carcinoma 10.1 TP53 MDM2
17 verrucous carcinoma 10.1 TP53 MDM2
18 undifferentiated embryonal sarcoma of the liver 10.1 TP53 MDM2
19 embryonal sarcoma 10.1 TP53 MDM2
20 pediatric liposarcoma 10.1 TP53 MDM2
21 hypertrophy of breast 10.1 TP53 OR7C1
22 maxillary sinus adenocarcinoma 10.1 TP53 MDM2
23 osteomyelitis 10.1
24 soft tissue sarcoma 10.1 TP53 MDM2
25 sarcoma 10.1
26 spindle cell sarcoma 10.1
27 parameningeal embryonal rhabdomyosarcoma 10.1 TP53 MDM2
28 conventional fibrosarcoma 10.1 TP53 MDM2
29 adult astrocytic tumour 10.1 TP53 MDM2
30 lip cancer 10.1 TP53 MDM2
31 malignant spiradenoma 10.1 TP53 MDM2
32 mandibular cancer 10.1 MDM2 GNAS
33 familial retinoblastoma 10.0 TP53 MDM2
34 anal squamous cell carcinoma 10.0 TP53 MDM2
35 sapho syndrome 10.0 TP53 MDM2
36 sarcomatoid renal cell carcinoma 10.0 TP53 MDM2
37 gliomatosis cerebri 10.0 TP53 MDM2
38 malignant exocrine pancreas neoplasm 10.0 TP53 GNAS
39 pituitary carcinoma 10.0 TP53 GNAS
40 cardia cancer 9.9 TP53 MDM2
41 fibroma 9.9
42 pulmonary edema 9.9
43 mitral valve stenosis 9.9
44 acute kidney failure 9.9
45 pleomorphic adenoma 9.9
46 epulis 9.9
47 kidney disease 9.9
48 juxtacortical chondrosarcoma 9.9
49 pyogenic granuloma 9.9
50 overgrowth syndrome 9.9

Graphical network of the top 20 diseases related to Periosteal Osteogenic Sarcoma:



Diseases related to Periosteal Osteogenic Sarcoma
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Symptoms & Phenotypes for Periosteal Osteogenic Sarcoma

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GenomeRNAi Phenotypes related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased BBC3 mRNA expression GR00389-S-4 8.32 DACH1

MGI Mouse Phenotypes related to Periosteal Osteogenic Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 DACH1 GNAS MDM2 SATB2 TP53 WWOX
2 skeleton MP:0005390 9.23 CRTAP DACH1 EXT2 GNAS MDM2 SATB2
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Drugs & Therapeutics for Periosteal Osteogenic Sarcoma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Parosteal OsTeosarcoma: a Single Istitution Experience Unknown status NCT03768076

Search NIH Clinical Center for Periosteal Osteogenic Sarcoma

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Genetic Tests for Periosteal Osteogenic Sarcoma

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Anatomical Context for Periosteal Osteogenic Sarcoma

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MalaCards organs/tissues related to Periosteal Osteogenic Sarcoma:

40
Bone Marrow, Lymph Node
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Publications for Periosteal Osteogenic Sarcoma

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Articles related to Periosteal Osteogenic Sarcoma:

(show top 50) (show all 119)
# Title Authors PMID Year
1
Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report. 61
32299473 2020
2
[Osteoid-forming bone tumors : Morphology and current translational cell biology]. 61
32078700 2020
3
Late onset hyperplastic callus formation in osteogenesis imperfecta type V simulating osteosarcoma-A case report. 61
32305663 2020
4
Efficacy of a Modified Scoring System to Facilitate Surgical Decision-making for Diaphyseal Malignancies: When is Devitalized Tumor-bearing Autograft of Value? 61
31402605 2019
5
Unusual Focal Muscle FDG Activity Related to Altered Biomechanics. 61
30516674 2019
6
Usefulness of Quantitative Bone Single Photon Emission Computed Tomography/Computed Tomography for Evaluating Response to Neoadjuvant Chemotherapy in a Patient with Periosteal Osteosarcoma. 61
30723654 2018
7
Periosteal Osteosarcoma: A Single-Institutional Study of Factors Related to Oncologic Outcomes. 61
30363676 2018
8
A Case Report of Heel Pain Mimicking Plantar Fasciitis and Osteosarcoma: A Unique Presentation of a Nora's Lesion. 61
28268143 2017
9
Intentional marginal resection of periosteal osteosarcoma in combination with neoadjuvant chemotherapy: A report of two cases and a review of the literature. 61
28454259 2017
10
Bizarre parosteal osteochondromatous proliferation (Nora's lesion) affecting the distal end of the ulna: a case report. 61
26984018 2016
11
Advances in the management of osteosarcoma. 61
27990273 2016
12
Periosteal osteosarcoma and Marfan's syndrome: A case report and literature review. 61
26870209 2016
13
Surface osteosarcoma: Clinical features and therapeutic implications. 61
26730360 2015
14
DACH1 Expresison in Osteosarcoma and Its Relationship with Proliferation and Angiogenesis. 61
26246702 2015
15
Reconstruction of bone defect with autograft fibula and retained part of tibia after marginal resection of periosteal osteosarcoma: a case report. 61
26084574 2015
16
Periosteal osteosarcoma of the mandible: a case report. 61
25795582 2015
17
MDM2 and CDK4 expression in periosteal osteosarcoma. 61
25680902 2015
18
Periosteal osteosarcoma: a review of clinical evidence. 61
25784972 2015
19
[Periosteal osteosarcoma - personal experience with five cases]. 61
26585111 2015
20
Parosteal osteosarcoma: Report of a rare juxtacortical variant of osteosarcoma affecting the maxilla. 61
25949002 2014
21
Periosteal osteosarcoma arising from the rib and scapula: imaging features in two cases. 61
24843242 2014
22
Oncological and functional outcome of periosteal osteosarcoma. 61
24932034 2014
23
Oral medicine case book 45. Periosteal osteosarcoma of the mandible. 61
23957106 2012
24
Case report: periosteal osteosarcoma of the clavicle. 61
22349647 2012
25
Bilateral synchronous tibial periosteal osteosarcoma with familial incidence. 61
22349598 2012
26
Periosteal osteosarcoma of the calcaneum: a case report. 61
22343818 2012
27
The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis. 61
22042095 2012
28
Periosteal osteosarcoma of the fifth metatarsal: a rare pedal tumor. 61
21764608 2011
29
Periosteal osteosarcoma of the mandible: case report and review of the literature. 61
21272969 2011
30
Periosteal osteosarcoma: a single-institution experience. 61
21472720 2011
31
Periosteal osteosarcoma of the shaft of the ulna. 61
21116904 2010
32
Intercalary allograft reconstructions using a compressible intramedullary nail: a preliminary report. 61
20146034 2010
33
Primary bone malignancy: effective treatment with high-intensity focused ultrasound ablation. 61
20501734 2010
34
Periosteal osteoblastoma of the distal femur. 61
19492573 2009
35
Parosteal osteosarcoma. 61
19507652 2009
36
Periosteal osteosarcoma in the hand of a pediatric patient: a case report. 61
18294553 2008
37
Endoprosthetic reconstruction for malignant bone and soft-tissue tumors. 61
17487125 2007
38
Periosteal osteosarcoma: long-term outcome and risk of late recurrence. 61
16906092 2006
39
Three cases with periosteal osteosarcoma arising from the femur. 61
16568399 2006
40
Periosteal osteosarcoma--a European review of outcome. 61
16290134 2005
41
[Application of histochemical staining in diagnosis of osteosarcomas]. 61
16188149 2005
42
A rare case of periosteal osteoblastoma located in the frontal cranial bone. 61
15913430 2005
43
Periosteal osteosarcoma of the mandible. 61
15883947 2005
44
Imaging of periosteal osteosarcoma: radiologic-pathologic comparison. 61
15333772 2004
45
Periosteal osteoblastoma of the distal femur. 61
14714148 2004
46
Periosteal osteosarcoma with secondary bone marrow involvement: a case report. 61
16228687 2004
47
A Phase II Study of Docetaxel for the Treatment of Recurrent Osteosarcoma. 61
18521398 2004
48
Distal recurrence of periosteal osteosarcoma after complete excision of proximal primary tumour with good excision margins. 61
18521373 2003
49
Cortical lesions of the tibia: characteristic appearances at conventional radiography. 61
12533651 2003
50
Periosteal Osteosarcoma: A Review of 17 Cases with Mean Follow-up of 52 Months. 61
18521348 2002
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Variations for Periosteal Osteogenic Sarcoma

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Expression for Periosteal Osteogenic Sarcoma

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Search GEO for disease gene expression data for Periosteal Osteogenic Sarcoma.
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Pathways for Periosteal Osteogenic Sarcoma

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Pathways related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
DNA Damage 4
12.05 WWOX TP53 MDM2
2
Integrated Cancer Pathway 1
11.03 TP53 MDM2
3
DNA damage_ATM/ATR regulation of G1/S checkpoint 23
10.97 TP53 MDM2
4
Oncogene Induced Senescence 65
10.76 TP53 MDM2
5
Aurora A signaling 1
10.65 TP53 MDM2
6
TP53 Network 1
Show member pathways
 10.3 TP53 MDM2
7
Inhibition of Ribosome Biogenesis by p14(ARF) 63
9.97 TP53 MDM2
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GO Terms for Periosteal Osteogenic Sarcoma

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Cellular components related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 TP53 SATB2 DACH1

Biological processes related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.67 TP53 MDM2 GNAS
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.55 WWOX TP53 SATB2 MDM2 DACH1
3 negative regulation of fibroblast proliferation GO:0048147 9.48 TP53 DACH1
4 response to antibiotic GO:0046677 9.46 TP53 MDM2
5 cellular response to gamma radiation GO:0071480 9.43 TP53 MDM2
6 cellular response to organic substance GO:0071310 9.4 SATB2 MDM2
7 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.37 WWOX TP53
8 positive regulation of protein export from nucleus GO:0046827 9.32 TP53 MDM2
9 cardiac septum morphogenesis GO:0060411 9.26 TP53 MDM2
10 cellular response to UV-C GO:0071494 8.96 TP53 MDM2
11 cellular response to actinomycin D GO:0072717 8.62 TP53 MDM2

Molecular functions related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 TP53 MDM2
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Sources for Periosteal Osteogenic Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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