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MCID: PRS029
MIFTS: 37

Periosteal Osteogenic Sarcoma

Categories: Cancer diseases, Bone diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Periosteal Osteogenic Sarcoma

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MalaCards integrated aliases for Periosteal Osteogenic Sarcoma:

Name: Periosteal Osteogenic Sarcoma 12 15
Periosteal Osteosarcoma 12 73
Parosteal Osteosarcoma 73

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6489
NCIt 50 C8970
SNOMED-CT 68 128772005 91242000
UMLS 73 C1377843
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Summaries for Periosteal Osteogenic Sarcoma

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MalaCards based summary : Periosteal Osteogenic Sarcoma, also known as periosteal osteosarcoma, is related to conventional central osteosarcoma and undifferentiated embryonal sarcoma of the liver. An important gene associated with Periosteal Osteogenic Sarcoma is DACH1 (Dachshund Family Transcription Factor 1), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and Endometrial cancer. Affiliated tissues include bone and testes, and related phenotypes are Decreased TP53 mRNA expression and Increased BBC3 mRNA expression

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Related Diseases for Periosteal Osteogenic Sarcoma

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Diseases related to Periosteal Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 conventional central osteosarcoma 10.7 MDM2 SATB2
2 undifferentiated embryonal sarcoma of the liver 10.6 CDK4 MDM2
3 infiltrating angiolipoma 10.6 CDK4 MDM2
4 spindle cell lipoma 10.6 CDK4 MDM2
5 inflammatory mfh 10.6 CDK4 MDM2
6 lipoblastoma 10.5 CDK4 MDM2
7 atypical lipomatous tumor 10.5 CDK4 MDM2
8 well-differentiated liposarcoma 10.4 CDK4 MDM2
9 fibrosarcomatous osteosarcoma 10.4 BGLAP SPARC
10 childhood oligodendroglioma 10.4 IDH1 MDM2
11 chondroid lipoma 10.4 CDK4 MDM2
12 small intestine leiomyosarcoma 10.4 CD34 IGF2
13 bone osteosarcoma 10.4 CDK4 MDM2 SATB2
14 small intestinal sarcoma 10.4 CD34 IGF2
15 conventional fibrosarcoma 10.3 CD34 MDM2
16 papillary cystadenocarcinoma 10.3 BGLAP SPARC
17 periosteal chondrosarcoma 10.3 CDK4 IDH1 MDM2
18 chondroblastic osteosarcoma 10.3 BGLAP IDH1
19 gastric leiomyosarcoma 10.3 CD34 IGF2
20 osteogenic sarcoma 10.3
21 sarcoma 10.3
22 periostitis 10.3
23 intracranial chondrosarcoma 10.1 IDH1 TP53
24 cerebellar astrocytoma 10.1 IDH1 TP53
25 zika virus infection 10.1 MDM2 TP53
26 extraosseous osteosarcoma 10.1 CD34 CDK4 MDM2
27 actinic cheilitis 10.1 MDM2 TP53
28 mixed liposarcoma 10.1 CD34 CDK4 MDM2
29 ischemic fasciitis 10.1 CD34 CDK4 MDM2
30 spindle cell liposarcoma 10.1 CD34 CDK4 MDM2
31 infiltrating lipoma 10.1 CD34 CDK4 MDM2
32 pleomorphic lipoma 10.1 CD34 CDK4 MDM2
33 mixed glioma 10.0 IDH1 TP53
34 lip cancer 10.0 MDM2 TP53
35 glioma susceptibility 1 10.0 IDH1 TP53
36 alveolar periostitis 10.0 BGLAP JUN
37 photokeratitis 10.0 FOS JUN
38 fibrillary astrocytoma 9.9 IDH1 TP53
39 cerebral neuroblastoma 9.9 IGF2 TP53
40 cellular neurofibroma 9.9 CD34 TP53
41 lymph node cancer 9.9 FOS TP53
42 marek disease 9.8 JUN TP53
43 sarcomatoid squamous cell skin carcinoma 9.8 CD34 TP53
44 gliomatosis cerebri 9.8 IDH1 MDM2 TP53
45 adult medulloblastoma 9.8 IDH1 MDM2 TP53
46 giant cell glioblastoma 9.8 IDH1 MDM2 TP53
47 ring chromosome 7 9.7 CDK4 MDM2 TP53
48 li-fraumeni syndrome 9.7 IDH1 MDM2 TP53
49 pleomorphic xanthoastrocytoma 9.7 IDH1 TP53
50 dedifferentiated liposarcoma 9.7 CDK4 MDM2 TP53

Graphical network of the top 20 diseases related to Periosteal Osteogenic Sarcoma:



Diseases related to Periosteal Osteogenic Sarcoma
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Symptoms & Phenotypes for Periosteal Osteogenic Sarcoma

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GenomeRNAi Phenotypes related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 8.96 JUN TP53
2 Increased BBC3 mRNA expression GR00389-S-4 8.62 DACH1 TP53

MGI Mouse Phenotypes related to Periosteal Osteogenic Sarcoma:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 DACH1 CD34 FOS CDK4 IGF2 MDM2
2 homeostasis/metabolism MP:0005376 10.19 IDH1 DACH1 IGF2 CD34 FOS CDK4
3 behavior/neurological MP:0005386 10.18 DACH1 FOS CDK4 JUN IGF2 MDM2
4 growth/size/body region MP:0005378 10.18 IDH1 FOS CDK4 SATB2 JUN IGF2
5 hematopoietic system MP:0005397 10.16 IGF2 CD34 FOS CDK4 IDH1 SPARC
6 endocrine/exocrine gland MP:0005379 10.14 DACH1 IGF2 FOS CDK4 MDM2 JUN
7 immune system MP:0005387 10.13 IDH1 IGF2 CD34 FOS CDK4 SPARC
8 embryo MP:0005380 10.09 FOS CDK4 JUN IGF2 MDM2 SATB2
9 integument MP:0010771 10.06 IGF2 FOS CD34 CDK4 SPARC MDM2
10 mortality/aging MP:0010768 10.06 CDK4 IDH1 DACH1 FOS SATB2 JUN
11 craniofacial MP:0005382 10.03 FOS SATB2 IGF2 MDM2 SPARC TP53
12 nervous system MP:0003631 9.92 CDK4 DACH1 FOS SATB2 JUN IGF2
13 limbs/digits/tail MP:0005371 9.91 FOS IGF2 MDM2 SATB2 SPARC TP53
14 neoplasm MP:0002006 9.85 CD34 FOS CDK4 SPARC MDM2 TP53
15 respiratory system MP:0005388 9.63 IDH1 DACH1 SATB2 JUN IGF2 TP53
16 pigmentation MP:0001186 9.56 CDK4 MDM2 TP53 SPARC
17 skeleton MP:0005390 9.56 IGF2 FOS IDH1 SPARC MDM2 JUN
18 vision/eye MP:0005391 9.1 CDK4 FOS JUN IGF2 TP53 SPARC
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Drugs & Therapeutics for Periosteal Osteogenic Sarcoma

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Search Clinical Trials , NIH Clinical Center for Periosteal Osteogenic Sarcoma

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Genetic Tests for Periosteal Osteogenic Sarcoma

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Anatomical Context for Periosteal Osteogenic Sarcoma

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MalaCards organs/tissues related to Periosteal Osteogenic Sarcoma:

41
Bone, Testes
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Publications for Periosteal Osteogenic Sarcoma

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Articles related to Periosteal Osteogenic Sarcoma:

# Title Authors Year
1
Test and teach. Number fifty-nine. Diagnosis: Periosteal osteogenic sarcoma. ( 2668864 )
1989
2
Periosteal osteogenic sarcoma of the mandible. ( 6588346 )
1984
3
Periosteal osteogenic sarcoma. ( 1063059 )
1976
4
Periosteal osteogenic sarcoma of the right femur following trauma; case report. ( 18875622 )
1948
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Variations for Periosteal Osteogenic Sarcoma

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Expression for Periosteal Osteogenic Sarcoma

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Search GEO for disease gene expression data for Periosteal Osteogenic Sarcoma.
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Pathways for Periosteal Osteogenic Sarcoma

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Pathways related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Cellular Senescence (REACTOME) 66
Show member pathways
 13.04 CDK4 FOS JUN MDM2 TP53
2
Endometrial cancer 37
Show member pathways
 12.76 CDK4 FOS JUN MDM2 TP53
3
Influenza A 37
Show member pathways
 12.71 CDK4 FOS JUN TP53
4
Apoptosis Modulation and Signaling 1
Show member pathways
 12.7 FOS IGF2 JUN MDM2 TP53
5
MAPK signaling pathway 1 37
12.68 FOS IGF2 JUN TP53
6
Glioma 37
Show member pathways
 12.6 CDK4 FOS JUN MDM2 TP53
7
Gastric cancer 37
Show member pathways
 12.59 CDK4 FOS IGF2 JUN TP53
8
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.49 CDK4 FOS JUN TP53
9
Development EGFR signaling pathway 22
Show member pathways
 12.45 FOS JUN MDM2 TP53
10
DNA Damage 4
12.42 CDK4 FOS MDM2 TP53
11
ErbB signaling pathway 1 37
Show member pathways
 12.39 FOS JUN MDM2 TP53
12
HTLV-I infection 37
12.34 CDK4 FOS JUN TP53
13
Toll Comparative Pathway 64
Show member pathways
 12.2 FOS JUN TP53
14
Viral carcinogenesis 37
12.16 CDK4 JUN MDM2 TP53
15
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.15 CDK4 FOS JUN
16
Pathways in cancer 37
12.15 CDK4 FOS IGF2 JUN MDM2 TP53
17
C-type lectin receptor signaling pathway 37
Show member pathways
 12.14 FOS JUN MDM2
18
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.13 FOS JUN TP53
19
Cellular senescence (KEGG) 37
12.09 CDK4 MDM2 TP53
20
p53 Signaling 64
Show member pathways
 12.09 CDK4 FOS MDM2 TP53
21
Immune response Function of MEF2 in T lymphocytes 22
Show member pathways
 12.05 FOS IGF2 JUN
22
Fluid shear stress and atherosclerosis 37
12.02 FOS JUN TP53
23
TGF-beta Signaling Pathway (WikiPathways) 1
11.99 FOS JUN TP53
24
Direct p53 effectors 1
11.99 JUN MDM2 TP53
25
Development IGF-1 receptor signaling 22
Show member pathways
 11.96 IGF2 MDM2 TP53
26
MAPK Pathway 72
Show member pathways
 11.95 FOS JUN TP53
27
Spinal Cord Injury 1
11.94 CDK4 FOS TP53
28
DNA Damage Response (only ATM dependent) 1
11.92 JUN MDM2 TP53
29
Cell cycle Cell cycle (generic schema) 22
Show member pathways
 11.9 CDK4 FOS JUN TP53
30
Integrated Breast Cancer Pathway 1
11.86 CDK4 JUN MDM2 TP53
31
UVA-Induced MAPK Signaling 64
Show member pathways
 11.84 FOS JUN TP53
32
SMAD Signaling Network 64
11.79 FOS JUN MDM2 TP53
33
Retinoblastoma (RB) in Cancer 1
11.78 CDK4 MDM2 TP53
34
ATM Pathway 64
Show member pathways
 11.77 JUN MDM2 TP53
35
Regulation of nuclear SMAD2/3 signaling 1
11.7 CDK4 FOS JUN
36
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.69 CDK4 FOS JUN
37
Bladder cancer 37 1
11.67 CDK4 MDM2 TP53
38
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.63 CDK4 FOS JUN
39
Glioblastoma Multiforme 64
11.6 CDK4 IGF2 MDM2 TP53
40
Regulation of retinoblastoma protein 1
11.54 BGLAP JUN MDM2
41
ATF-2 transcription factor network 1
11.52 CDK4 FOS JUN
42
Copper homeostasis 1
11.5 JUN MDM2 TP53
43
HIF1Alpha Pathway 64
11.49 JUN MDM2 TP53
44
Proteolysis Putative SUMO-1 pathway 22
Show member pathways
 11.48 JUN MDM2 TP53
45
Senescence and Autophagy in Cancer 1
11.48 JUN MDM2 SPARC TP53
46
Photodynamic therapy-induced AP-1 survival signaling. 1
11.43 FOS JUN TP53
47
FGF signaling pathway 1
11.34 BGLAP FOS JUN
48
Integrated Cancer Pathway 1
11.32 CDK4 MDM2 TP53
49
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.29 BGLAP FOS JUN
50
Transcription_Transcription factor Tubby signaling pathways 22
11.25 FOS JUN TP53
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GO Terms for Periosteal Osteogenic Sarcoma

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Cellular components related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.96 BGLAP CD34 CDK4 DACH1 FOS IDH1
2 nuclear matrix GO:0016363 9.33 SATB2 SPARC TP53
3 transcription factor complex GO:0005667 9.02 CDK4 DACH1 FOS JUN SATB2
4 transcription factor AP-1 complex GO:0035976 8.96 FOS JUN

Biological processes related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 DACH1 IGF2 JUN MDM2 SATB2 TP53
2 regulation of gene expression GO:0010468 9.78 CDK4 IGF2 MDM2 SATB2
3 aging GO:0007568 9.77 BGLAP FOS JUN
4 response to toxic substance GO:0009636 9.71 CDK4 FOS MDM2
5 response to organic substance GO:0010033 9.7 CDK4 IGF2 JUN
6 ossification GO:0001503 9.69 BGLAP IGF2 SPARC
7 response to mechanical stimulus GO:0009612 9.67 BGLAP FOS JUN
8 response to cytokine GO:0034097 9.63 FOS JUN SPARC
9 cellular response to gamma radiation GO:0071480 9.61 MDM2 TP53
10 cellular response to growth factor stimulus GO:0071363 9.61 BGLAP MDM2 SPARC
11 negative regulation of cell cycle arrest GO:0071157 9.59 CDK4 MDM2
12 response to lead ion GO:0010288 9.58 CDK4 SPARC
13 RNA polymerase II transcriptional preinitiation complex assembly GO:0051123 9.58 DACH1 TP53
14 response to cAMP GO:0051591 9.58 FOS JUN SPARC
15 positive regulation of protein export from nucleus GO:0046827 9.57 MDM2 TP53
16 osteoblast development GO:0002076 9.56 BGLAP SATB2
17 response to organic cyclic compound GO:0014070 9.56 BGLAP FOS IDH1 JUN
18 response to muscle stretch GO:0035994 9.55 FOS JUN
19 response to drug GO:0042493 9.55 BGLAP CDK4 FOS JUN MDM2
20 cellular response to actinomycin D GO:0072717 9.37 MDM2 TP53
21 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.13 FOS JUN TP53
22 response to gravity GO:0009629 8.8 BGLAP FOS SPARC

Molecular functions related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.46 FOS JUN SATB2 TP53
2 R-SMAD binding GO:0070412 9.32 FOS JUN
3 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190 9.26 FOS JUN
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.26 FOS JUN SATB2 TP53
5 transcription factor binding GO:0008134 8.92 CD34 FOS JUN TP53
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Sources for Periosteal Osteogenic Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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