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MCID: PRS029
MIFTS: 42

Periosteal Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Periosteal Osteogenic Sarcoma

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MalaCards integrated aliases for Periosteal Osteogenic Sarcoma:

Name: Periosteal Osteogenic Sarcoma 12 15
Periosteal Osteosarcoma 12 73
Parosteal Osteosarcoma 73

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6489
NCIt 50 C8970
SNOMED-CT 68 91242000
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Summaries for Periosteal Osteogenic Sarcoma

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MalaCards based summary : Periosteal Osteogenic Sarcoma, also known as periosteal osteosarcoma, is related to sarcoma and periosteal chondrosarcoma. An important gene associated with Periosteal Osteogenic Sarcoma is DACH1 (Dachshund Family Transcription Factor 1), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and Human cytomegalovirus infection. Affiliated tissues include bone, liver and lymph node, and related phenotypes are Decreased TP53 mRNA expression and Increased BBC3 mRNA expression

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Related Diseases for Periosteal Osteogenic Sarcoma

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Diseases related to Periosteal Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 sarcoma 30.1 CDK4 JUN MDM2 TP53
2 periosteal chondrosarcoma 30.0 CDK4 IDH1 MDM2
3 osteogenic sarcoma 10.4
4 extraosseous osteosarcoma 10.2 MDM2 SPARC
5 undifferentiated embryonal sarcoma of the liver 10.2 CDK4 MDM2
6 infiltrating angiolipoma 10.2 CDK4 MDM2
7 spindle cell lipoma 10.2 CDK4 MDM2
8 cellular myxoid liposarcoma 10.2 CDK4 MDM2
9 inflammatory mfh 10.2 CDK4 MDM2
10 childhood oligodendroglioma 10.2 IDH1 MDM2
11 lipoblastoma 10.1 CDK4 MDM2
12 atypical lipomatous tumor 10.1 CDK4 MDM2
13 papillary cystadenocarcinoma 10.1 BGLAP SPARC
14 chondroid lipoma 10.1 CDK4 MDM2
15 chondroblastic osteosarcoma 10.1 BGLAP IDH1
16 small intestine leiomyosarcoma 10.1 CD34 IGF2
17 well-differentiated liposarcoma 10.1 CDK4 MDM2
18 small intestinal sarcoma 10.1 CD34 IGF2
19 conventional fibrosarcoma 10.1 CD34 MDM2
20 fibrosarcomatous osteosarcoma 10.1 BGLAP SPARC
21 chondrosarcoma 10.1
22 intracranial chondrosarcoma 10.0 IDH1 TP53
23 cerebellar astrocytoma 10.0 IDH1 TP53
24 zika virus infection 10.0 MDM2 TP53
25 drug-induced mental disorder 10.0 FOS IDH1
26 actinic cheilitis 10.0 MDM2 TP53
27 mixed glioma 10.0 IDH1 TP53
28 mixed liposarcoma 10.0 CD34 CDK4 MDM2
29 spindle cell liposarcoma 10.0 CD34 CDK4 MDM2
30 ischemic fasciitis 10.0 CD34 CDK4 MDM2
31 infiltrating lipoma 10.0 CD34 CDK4 MDM2
32 drug psychosis 10.0 FOS IDH1
33 lip cancer 10.0 MDM2 TP53
34 alveolar periostitis 10.0 BGLAP JUN
35 glioma susceptibility 1 10.0 IDH1 TP53
36 cerebral neuroblastoma 10.0 IGF2 TP53
37 fibrillary astrocytoma 10.0 IDH1 TP53
38 photokeratitis 10.0 FOS JUN
39 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.0 SATB2 TP53
40 pleomorphic xanthoastrocytoma 10.0 IDH1 TP53
41 cellular neurofibroma 10.0 CD34 TP53
42 spinal cord astrocytoma 10.0 IDH1 TP53
43 lymph node cancer 10.0 FOS TP53
44 conventional central osteosarcoma 9.9 BGLAP MDM2 SATB2 SPARC
45 fibroepithelial basal cell carcinoma 9.9 CD34 TP53
46 soft tissue sarcoma 9.9 MDM2 TP53
47 gliomatosis cerebri 9.9 IDH1 MDM2 TP53
48 adult medulloblastoma 9.9 IDH1 MDM2 TP53
49 giant cell glioblastoma 9.9 IDH1 MDM2 TP53
50 supratentorial cancer 9.9 IDH1 MDM2 TP53

Graphical network of the top 20 diseases related to Periosteal Osteogenic Sarcoma:



Diseases related to Periosteal Osteogenic Sarcoma
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Symptoms & Phenotypes for Periosteal Osteogenic Sarcoma

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GenomeRNAi Phenotypes related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 8.96 JUN TP53
2 Increased BBC3 mRNA expression GR00389-S-4 8.62 DACH1 TP53

MGI Mouse Phenotypes related to Periosteal Osteogenic Sarcoma:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 CD34 CDK4 DACH1 FOS IGF2 JUN
2 homeostasis/metabolism MP:0005376 10.19 CD34 CDK4 DACH1 FOS IDH1 IGF2
3 behavior/neurological MP:0005386 10.18 CDK4 DACH1 FOS IGF2 JUN MDM2
4 growth/size/body region MP:0005378 10.18 CDK4 FOS IDH1 IGF2 JUN MDM2
5 hematopoietic system MP:0005397 10.16 CD34 CDK4 FOS IDH1 IGF2 JUN
6 endocrine/exocrine gland MP:0005379 10.14 CDK4 DACH1 FOS IGF2 JUN MDM2
7 immune system MP:0005387 10.13 CD34 CDK4 FOS IDH1 IGF2 JUN
8 embryo MP:0005380 10.09 CDK4 FOS IGF2 JUN MDM2 SATB2
9 integument MP:0010771 10.06 CD34 CDK4 FOS IGF2 JUN MDM2
10 mortality/aging MP:0010768 10.06 CDK4 DACH1 FOS IDH1 IGF2 JUN
11 craniofacial MP:0005382 10.03 FOS IGF2 MDM2 SATB2 SPARC TP53
12 nervous system MP:0003631 9.92 CDK4 DACH1 FOS IGF2 JUN MDM2
13 limbs/digits/tail MP:0005371 9.91 FOS IGF2 MDM2 SATB2 SPARC TP53
14 neoplasm MP:0002006 9.85 CD34 CDK4 FOS MDM2 SPARC TP53
15 respiratory system MP:0005388 9.63 DACH1 IDH1 IGF2 JUN SATB2 TP53
16 pigmentation MP:0001186 9.56 CDK4 MDM2 SPARC TP53
17 skeleton MP:0005390 9.56 FOS IDH1 IGF2 JUN MDM2 SATB2
18 vision/eye MP:0005391 9.1 CDK4 FOS IGF2 JUN SPARC TP53
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Drugs & Therapeutics for Periosteal Osteogenic Sarcoma

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Search Clinical Trials , NIH Clinical Center for Periosteal Osteogenic Sarcoma

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Genetic Tests for Periosteal Osteogenic Sarcoma

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Anatomical Context for Periosteal Osteogenic Sarcoma

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MalaCards organs/tissues related to Periosteal Osteogenic Sarcoma:

41
Bone, Liver, Lymph Node, Spinal Cord, Prostate, Myeloid, Small Intestine
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Publications for Periosteal Osteogenic Sarcoma

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Articles related to Periosteal Osteogenic Sarcoma:

(show top 50) (show all 57)
# Title Authors Year
1
Periosteal Osteosarcoma: A Single-Institutional Study of Factors Related to Oncologic Outcomes. ( 30363676 )
2018
2
Intentional marginal resection of periosteal osteosarcoma in combination with neoadjuvant chemotherapy: A report of two cases and a review of the literature. ( 28454259 )
2017
3
Periosteal osteosarcoma and Marfan's syndrome: A case report and literature review. ( 26870209 )
2016
4
Periosteal osteosarcoma: a review of clinical evidence. ( 25784972 )
2015
5
Periosteal osteosarcoma of the mandible: a case report. ( 25795582 )
2015
6
Reconstruction of bone defect with autograft fibula and retained part of tibia after marginal resection of periosteal osteosarcoma: a case report. ( 26084574 )
2015
7
Periosteal osteosarcoma arising from the rib and scapula: imaging features in two cases. ( 24843242 )
2014
8
Oncological and functional outcome of periosteal osteosarcoma. ( 24932034 )
2014
9
Periosteal osteosarcoma of the calcaneum: a case report. ( 22343818 )
2012
10
Bilateral synchronous tibial periosteal osteosarcoma with familial incidence. ( 22349598 )
2012
11
Case report: periosteal osteosarcoma of the clavicle. ( 22349647 )
2012
12
Periosteal osteosarcoma of the mandible: case report and review of the literature. ( 21272969 )
2011
13
Periosteal osteosarcoma: a single-institution experience. ( 21472720 )
2011
14
Periosteal osteosarcoma of the fifth metatarsal: a rare pedal tumor. ( 21764608 )
2011
15
Periosteal osteosarcoma of the shaft of the ulna. ( 21116904 )
2010
16
Periosteal osteosarcoma in the hand of a pediatric patient: a case report. ( 18294553 )
2008
17
Periosteal osteosarcoma: long-term outcome and risk of late recurrence. ( 16906092 )
2006
18
Three cases with periosteal osteosarcoma arising from the femur. ( 16568399 )
2006
19
Periosteal osteosarcoma of the mandible. ( 15883947 )
2005
20
Periosteal osteosarcoma--a European review of outcome. ( 16290134 )
2005
21
Imaging of periosteal osteosarcoma: radiologic-pathologic comparison. ( 15333772 )
2004
22
Periosteal osteosarcoma with secondary bone marrow involvement: a case report. ( 16228687 )
2004
23
Distal recurrence of periosteal osteosarcoma after complete excision of proximal primary tumour with good excision margins. ( 18521373 )
2003
24
Periosteal Osteosarcoma: A Review of 17 Cases with Mean Follow-up of 52 Months. ( 18521348 )
2002
25
Periosteal osteosarcoma of the mandible. ( 11803391 )
2002
26
Periosteal osteosarcoma of the jaws: report of 2 cases. ( 10711625 )
2000
27
Quiz case 1. Periosteal osteosarcoma (PO) of the mandible. ( 10772315 )
2000
28
Periosteal osteosarcoma of the cranium. ( 11073335 )
2000
29
Periosteal osteosarcoma. ( 10535561 )
1999
30
Painful mass adjacent to the tibial tubercle of a 14-year-old boy. Periosteal osteosarcoma. ( 9186230 )
1997
31
Periosteal osteosarcoma of the tibia. ( 9308458 )
1997
32
Periosteal osteosarcoma in the long head of the triceps in a dog. ( 7552664 )
1995
33
Periosteal osteosarcoma of the mandible. ( 7594757 )
1995
34
Chondroblastic, grade 3 periosteal osteosarcoma. ( 7709260 )
1995
35
Periosteal osteosarcoma and parosteal chondrosarcoma evaluated by double immunohistochemical staining. Report of 2 cases. ( 7518993 )
1994
36
Case report 852. Periosteal osteosarcoma of femur. ( 7939844 )
1994
37
Misinterpreted periosteal osteosarcoma. A cautionary tale. ( 8041946 )
1994
38
Periosteal osteosarcoma of the femur with bone marrow involvement: a case report. ( 8044311 )
1994
39
Case report 793. Periosteal osteosarcoma of the clavicle. ( 8372368 )
1993
40
Resection of a periosteal osteosarcoma and reconstruction using the Ilizarov technique of segmental transport. ( 8501358 )
1993
41
Periosteal osteosarcoma of the scapula in a horse. ( 17424340 )
1993
42
Periosteal osteosarcoma of the maxilla: a case report and review of literature. ( 2184205 )
1990
43
Radiologic case study. Periosteal osteosarcoma. ( 2197613 )
1990
44
Test and teach. Number fifty-nine. Diagnosis: Periosteal osteogenic sarcoma. ( 2668864 )
1989
45
Periosteal osteosarcoma. ( 3472700 )
1987
46
Bilateral metachronous periosteal osteosarcoma. ( 3460685 )
1986
47
Periosteal osteosarcoma. ( 3965078 )
1985
48
Periosteal osteogenic sarcoma of the mandible. ( 6588346 )
1984
49
Metastatic periosteal osteosarcoma causing cardiac and renal failure. ( 6574700 )
1983
50
Case report 142. Periosteal osteosarcoma of femur. ( 6942510 )
1981
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Variations for Periosteal Osteogenic Sarcoma

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Expression for Periosteal Osteogenic Sarcoma

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Search GEO for disease gene expression data for Periosteal Osteogenic Sarcoma.
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Pathways for Periosteal Osteogenic Sarcoma

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Pathways related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Cellular Senescence (REACTOME) 66
Show member pathways
 13.05 CDK4 FOS JUN MDM2 TP53
2
Human cytomegalovirus infection 37
Show member pathways
 12.97 CDK4 FOS JUN MDM2 TP53
3
Endometrial cancer 37
Show member pathways
 12.77 CDK4 FOS JUN MDM2 TP53
4
Influenza A 37
Show member pathways
 12.71 CDK4 FOS JUN TP53
5
MAPK signaling pathway 37 1
12.68 FOS IGF2 JUN TP53
6
Apoptosis Modulation and Signaling 1
Show member pathways
 12.68 FOS IGF2 JUN MDM2 TP53
7
Glioma 37
Show member pathways
 12.62 CDK4 FOS JUN MDM2 TP53
8
Gastric cancer 37
Show member pathways
 12.6 CDK4 FOS IGF2 JUN TP53
9
Development EGFR signaling pathway 22
Show member pathways
 12.46 FOS JUN MDM2 TP53
10
DNA Damage 4
12.43 CDK4 FOS MDM2 TP53
11
ErbB signaling pathway 1 37
Show member pathways
 12.41 FOS JUN MDM2 TP53
12
WNT Signaling 64
12.35 CDK4 FOS JUN TP53
13
Human T-cell leukemia virus 1 infection 37
12.35 CDK4 FOS JUN TP53
14
Development IGF-1 receptor signaling 22
Show member pathways
 12.31 FOS IGF2 MDM2 TP53
15
Epstein-Barr virus infection 37
12.18 CDK4 JUN MDM2 TP53
16
Viral carcinogenesis 37
12.17 CDK4 JUN MDM2 TP53
17
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.15 CDK4 FOS JUN
18
Pathways in cancer 37
12.15 CDK4 FOS IGF2 JUN MDM2 TP53
19
C-type lectin receptor signaling pathway 37
Show member pathways
 12.14 FOS JUN MDM2
20
Cellular senescence (KEGG) 37
12.1 CDK4 MDM2 TP53
21
AKT Signaling Pathway 67
12.06 CDK4 MDM2 TP53
22
Immune response Function of MEF2 in T lymphocytes 22
Show member pathways
 12.06 FOS IGF2 JUN
23
p53 Signaling 64
Show member pathways
 12.03 CDK4 FOS MDM2 TP53
24
Fluid shear stress and atherosclerosis 37
12.02 FOS JUN TP53
25
TGF-beta Signaling Pathway (WikiPathways) 1
12 FOS JUN TP53
26
Direct p53 effectors 1
11.99 JUN MDM2 TP53
27
UVA-Induced MAPK Signaling 64
Show member pathways
 11.98 FOS JUN TP53
28
MAPK Pathway 72
Show member pathways
 11.96 FOS JUN TP53
29
Spinal Cord Injury 1
11.95 CDK4 FOS TP53
30
DNA Damage Response (only ATM dependent) 1
11.92 JUN MDM2 TP53
31
Cell cycle Cell cycle (generic schema) 22
Show member pathways
 11.91 CDK4 FOS JUN TP53
32
Integrated Breast Cancer Pathway 1
11.86 CDK4 JUN MDM2 TP53
33
SMAD Signaling Network 64
11.82 FOS JUN MDM2 TP53
34
Retinoblastoma (RB) in Cancer 1
11.79 CDK4 MDM2 TP53
35
ATM Pathway 64
Show member pathways
 11.78 JUN MDM2 TP53
36
Regulation of nuclear SMAD2/3 signaling 1
11.71 CDK4 FOS JUN
37
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.7 CDK4 FOS JUN
38
Bladder cancer 37 1
11.68 CDK4 MDM2 TP53
39
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.64 CDK4 FOS JUN
40
Glioblastoma Multiforme 64
11.6 CDK4 IGF2 MDM2 TP53
41
Regulation of retinoblastoma protein 1
11.54 BGLAP JUN MDM2
42
ATF-2 transcription factor network 1
11.53 CDK4 FOS JUN
43
Copper homeostasis 1
11.51 JUN MDM2 TP53
44
HIF1Alpha Pathway 64
11.51 JUN MDM2 TP53
45
Proteolysis Putative SUMO-1 pathway 22
Show member pathways
 11.5 JUN MDM2 TP53
46
Senescence and Autophagy in Cancer 1
11.48 JUN MDM2 SPARC TP53
47
Photodynamic therapy-induced AP-1 survival signaling. 1
11.44 FOS JUN TP53
48
Transcription_P53 signaling pathway 22
11.44 FOS JUN MDM2 TP53
49
FGF signaling pathway 1
11.37 BGLAP FOS JUN
50
Integrated Cancer Pathway 1
11.35 CDK4 MDM2 TP53
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GO Terms for Periosteal Osteogenic Sarcoma

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Cellular components related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear matrix GO:0016363 9.33 SATB2 SPARC TP53
2 transcription factor complex GO:0005667 9.02 CDK4 DACH1 FOS JUN SATB2
3 transcription factor AP-1 complex GO:0035976 8.96 FOS JUN

Biological processes related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 DACH1 IGF2 JUN MDM2 SATB2 TP53
2 aging GO:0007568 9.77 BGLAP FOS JUN
3 response to lipopolysaccharide GO:0032496 9.77 FOS JUN SPARC
4 response to toxic substance GO:0009636 9.69 CDK4 FOS MDM2
5 ossification GO:0001503 9.67 BGLAP IGF2 SPARC
6 response to mechanical stimulus GO:0009612 9.65 BGLAP FOS JUN
7 response to cytokine GO:0034097 9.63 FOS JUN SPARC
8 cellular response to growth factor stimulus GO:0071363 9.61 BGLAP MDM2 SPARC
9 regulation of DNA-binding transcription factor activity GO:0051090 9.58 FOS JUN
10 negative regulation of cell cycle arrest GO:0071157 9.58 CDK4 MDM2
11 response to cAMP GO:0051591 9.58 FOS JUN SPARC
12 RNA polymerase II preinitiation complex assembly GO:0051123 9.57 DACH1 TP53
13 response to lead ion GO:0010288 9.56 CDK4 SPARC
14 response to organic cyclic compound GO:0014070 9.56 BGLAP FOS IDH1 JUN
15 positive regulation of protein export from nucleus GO:0046827 9.55 MDM2 TP53
16 osteoblast development GO:0002076 9.54 BGLAP SATB2
17 response to muscle stretch GO:0035994 9.52 FOS JUN
18 cellular response to actinomycin D GO:0072717 9.37 MDM2 TP53
19 response to drug GO:0042493 9.35 BGLAP CDK4 FOS JUN MDM2
20 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.33 FOS JUN TP53
21 response to gravity GO:0009629 8.8 BGLAP FOS SPARC

Molecular functions related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.46 FOS JUN SATB2 TP53
2 R-SMAD binding GO:0070412 9.26 FOS JUN
3 transcription factor binding GO:0008134 9.26 CD34 FOS JUN TP53
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.02 DACH1 FOS JUN SATB2 TP53
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Sources for Periosteal Osteogenic Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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