MCID: PRS029
MIFTS: 32

Periosteal Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases
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Aliases & Classifications for Periosteal Osteogenic Sarcoma

MalaCards integrated aliases for Periosteal Osteogenic Sarcoma:

Name: Periosteal Osteogenic Sarcoma 11 14
Periosteal Osteosarcoma 11 71
Parosteal Osteosarcoma 71

Classifications:



External Ids:

Disease Ontology 11 DOID:6489
NCIt 49 C8970
SNOMED-CT 68 91242000
UMLS 71 C0206642 C1377843

Summaries for Periosteal Osteogenic Sarcoma

MalaCards based summary: Periosteal Osteogenic Sarcoma, also known as periosteal osteosarcoma, is related to periosteal chondrosarcoma and chondrosarcoma. An important gene associated with Periosteal Osteogenic Sarcoma is WWOX (WW Domain Containing Oxidoreductase), and among its related pathways/superpathways are Defective EXT2 causes exostoses 2 and Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome. Affiliated tissues include bone, bone marrow and lymph node, and related phenotypes are embryo and cellular

Related Diseases for Periosteal Osteogenic Sarcoma

Diseases related to Periosteal Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 periosteal chondrosarcoma 30.6 EXT2 EXT1
2 chondrosarcoma 30.5 MDM2 EXT2 EXT1
3 parosteal osteosarcoma 30.3 SATB2 MDM2
4 conventional osteosarcoma 30.2 USP6 SATB2 MDM2
5 fibroma 30.1 USP6 SATB2
6 chondroblastic osteosarcoma 30.0 SATB2 H3-3B H3-3A
7 ossifying fibroma 29.1 USP6 SATB2 H3-3B H3-3A
8 osteogenic sarcoma 10.4
9 sarcoma 10.2
10 hereditary multiple osteochondromas 10.2 EXT2 EXT1
11 osteochondroma 10.2 EXT2 EXT1
12 ankylosing spondylitis 3 10.2 EXT2 EXT1
13 exostoses, multiple, type i 10.2 EXT2 EXT1
14 juxtacortical chondroma 10.2 EXT2 EXT1
15 charcot-marie-tooth disease, x-linked recessive, 3 10.1 EXT2 EXT1
16 charcot-marie-tooth disease, x-linked recessive, 2 10.1 EXT2 EXT1
17 extraosseous osteosarcoma 10.1 SATB2 MDM2
18 fibrosarcomatous osteosarcoma 10.1 SATB2 MDM2
19 metachondromatosis 10.1 EXT2 EXT1
20 osteomyelitis 10.1
21 osteoblastoma 10.0 USP6 SATB2
22 hereditary multiple exostoses 10.0 EXT2 EXT1
23 exostosis 10.0 EXT2 EXT1
24 osteopoikilosis 10.0 LEMD3 EXT1
25 bone sarcoma 10.0 MDM2 EXT2 EXT1
26 trichorhinophalangeal syndrome, type ii 10.0 EXT2 EXT1
27 marfan syndrome 9.9
28 oculodentodigital dysplasia 9.9
29 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.9
30 osteofibrous dysplasia 9.9
31 pulmonary edema 9.9
32 mitral valve stenosis 9.9
33 bone cancer 9.9
34 acute kidney failure 9.9
35 mesenchymal cell neoplasm 9.9
36 turner syndrome 9.9
37 pleomorphic adenoma 9.9
38 epulis 9.9
39 kidney disease 9.9
40 juxtacortical chondrosarcoma 9.9
41 connective tissue disease 9.9
42 pyogenic granuloma 9.9
43 overgrowth syndrome 9.9
44 enchondromatosis, multiple, ollier type 9.9 EXT2 EXT1
45 giant cell reparative granuloma 9.9 USP6 H3-3A
46 bone giant cell sarcoma 9.9 H3-3B H3-3A
47 brain stem astrocytic neoplasm 9.9 H3-3B H3-3A
48 adult brain stem glioma 9.9 H3-3B H3-3A
49 brain stem glioma 9.9 H3-3B H3-3A
50 idh-wildtype anaplastic astrocytoma 9.9 H3-3B H3-3A

Graphical network of the top 20 diseases related to Periosteal Osteogenic Sarcoma:



Diseases related to Periosteal Osteogenic Sarcoma

Symptoms & Phenotypes for Periosteal Osteogenic Sarcoma

MGI Mouse Phenotypes related to Periosteal Osteogenic Sarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.7 EXT1 EXT2 H3-3A H3-3B LEMD3 MDM2
2 cellular MP:0005384 9.56 EXT1 H3-3A H3-3B IFITM5 LEMD3 MDM2
3 mortality/aging MP:0010768 9.28 EXT1 EXT2 H3-3A H3-3B IFITM5 LEMD3

Drugs & Therapeutics for Periosteal Osteogenic Sarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Parosteal OsTeosarcoma: a Single Istitution Experience Completed NCT03768076
2 Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry) Not yet recruiting NCT05515068

Search NIH Clinical Center for Periosteal Osteogenic Sarcoma

Genetic Tests for Periosteal Osteogenic Sarcoma

Anatomical Context for Periosteal Osteogenic Sarcoma

Organs/tissues related to Periosteal Osteogenic Sarcoma:

MalaCards : Bone, Bone Marrow, Lymph Node, Brain

Publications for Periosteal Osteogenic Sarcoma

Articles related to Periosteal Osteogenic Sarcoma:

(show top 50) (show all 126)
# Title Authors PMID Year
1
Periosteal chondrosarcoma: an unusual juxtacortical sarcoma. 62
36318319 2022
2
Effect of adjuvant chemotherapy on periosteal osteosarcoma: a systematic review. 62
35485208 2022
3
Periosteal osteosarcoma of the clavicle: A case report and review of the literature. 62
35878549 2022
4
Periosteal osteosarcoma of the femur treated with modified capanna procedure: A case report. 62
34555680 2021
5
Chemotherapy in the management of periosteal osteosarcoma: A narrative review. 62
34567961 2021
6
Surface osteosarcoma: Predictors of outcomes. 62
34043244 2021
7
Quantitative bone SPECT/CT applications for primary bone neoplasms. 62
33866337 2021
8
Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report. 62
32299473 2020
9
[Osteoid-forming bone tumors : Morphology and current translational cell biology]. 62
32078700 2020
10
Late onset hyperplastic callus formation in osteogenesis imperfecta type V simulating osteosarcoma-A case report. 62
32305663 2020
11
Efficacy of a Modified Scoring System to Facilitate Surgical Decision-making for Diaphyseal Malignancies: When is Devitalized Tumor-bearing Autograft of Value? 62
31402605 2019
12
Unusual Focal Muscle FDG Activity Related to Altered Biomechanics. 62
30516674 2019
13
Usefulness of Quantitative Bone Single Photon Emission Computed Tomography/Computed Tomography for Evaluating Response to Neoadjuvant Chemotherapy in a Patient with Periosteal Osteosarcoma. 62
30723654 2018
14
Periosteal Osteosarcoma: A Single-Institutional Study of Factors Related to Oncologic Outcomes. 62
30363676 2018
15
A Case Report of Heel Pain Mimicking Plantar Fasciitis and Osteosarcoma: A Unique Presentation of a Nora's Lesion. 62
28268143 2017
16
Intentional marginal resection of periosteal osteosarcoma in combination with neoadjuvant chemotherapy: A report of two cases and a review of the literature. 62
28454259 2017
17
Bizarre parosteal osteochondromatous proliferation (Nora's lesion) affecting the distal end of the ulna: a case report. 62
26984018 2016
18
Advances in the management of osteosarcoma. 62
27990273 2016
19
Periosteal osteosarcoma and Marfan's syndrome: A case report and literature review. 62
26870209 2016
20
Surface osteosarcoma: Clinical features and therapeutic implications. 62
26730360 2015
21
DACH1 Expresison in Osteosarcoma and Its Relationship with Proliferation and Angiogenesis. 62
26246702 2015
22
Reconstruction of bone defect with autograft fibula and retained part of tibia after marginal resection of periosteal osteosarcoma: a case report. 62
26084574 2015
23
MDM2 and CDK4 expression in periosteal osteosarcoma. 62
25680902 2015
24
Periosteal osteosarcoma of the mandible: a case report. 62
25795582 2015
25
Periosteal osteosarcoma: a review of clinical evidence. 62
25784972 2015
26
[Periosteal osteosarcoma - personal experience with five cases]. 62
26585111 2015
27
Parosteal osteosarcoma: Report of a rare juxtacortical variant of osteosarcoma affecting the maxilla. 62
25949002 2014
28
Periosteal osteosarcoma arising from the rib and scapula: imaging features in two cases. 62
24843242 2014
29
Oncological and functional outcome of periosteal osteosarcoma. 62
24932034 2014
30
Oral medicine case book 45. Periosteal osteosarcoma of the mandible. 62
23957106 2012
31
Case report: periosteal osteosarcoma of the clavicle. 62
22349647 2012
32
Bilateral synchronous tibial periosteal osteosarcoma with familial incidence. 62
22349598 2012
33
Periosteal osteosarcoma of the calcaneum: a case report. 62
22343818 2012
34
The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis. 62
22042095 2012
35
Periosteal osteosarcoma of the fifth metatarsal: a rare pedal tumor. 62
21764608 2011
36
Periosteal osteosarcoma of the mandible: case report and review of the literature. 62
21272969 2011
37
Periosteal osteosarcoma: a single-institution experience. 62
21472720 2011
38
Periosteal osteosarcoma of the shaft of the ulna. 62
21116904 2010
39
Intercalary allograft reconstructions using a compressible intramedullary nail: a preliminary report. 62
20146034 2010
40
Primary bone malignancy: effective treatment with high-intensity focused ultrasound ablation. 62
20501734 2010
41
Periosteal osteoblastoma of the distal femur. 62
19492573 2009
42
Parosteal osteosarcoma. 62
19507652 2009
43
Periosteal osteosarcoma in the hand of a pediatric patient: a case report. 62
18294553 2008
44
Endoprosthetic reconstruction for malignant bone and soft-tissue tumors. 62
17487125 2007
45
Periosteal osteosarcoma: long-term outcome and risk of late recurrence. 62
16906092 2006
46
Three cases with periosteal osteosarcoma arising from the femur. 62
16568399 2006
47
Periosteal osteosarcoma--a European review of outcome. 62
16290134 2005
48
[Application of histochemical staining in diagnosis of osteosarcomas]. 62
16188149 2005
49
A rare case of periosteal osteoblastoma located in the frontal cranial bone. 62
15913430 2005
50
Periosteal osteosarcoma of the mandible. 62
15883947 2005

Variations for Periosteal Osteogenic Sarcoma

Expression for Periosteal Osteogenic Sarcoma

Search GEO for disease gene expression data for Periosteal Osteogenic Sarcoma.

Pathways for Periosteal Osteogenic Sarcoma

GO Terms for Periosteal Osteogenic Sarcoma

Biological processes related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 telomere organization GO:0032200 9.81 H3-3B H3-3A
2 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.8 EXT2 EXT1
3 heart contraction GO:0060047 9.78 EXT2 EXT1
4 glycosaminoglycan biosynthetic process GO:0006024 9.76 EXT2 EXT1
5 sodium ion homeostasis GO:0055078 9.73 EXT2 EXT1
6 sulfation GO:0051923 9.71 EXT1 EXT2
7 cellular response to fibroblast growth factor stimulus GO:0044344 9.7 EXT2 EXT1
8 heparin biosynthetic process GO:0030210 9.67 EXT2 EXT1
9 multicellular organismal water homeostasis GO:0050891 9.62 EXT2 EXT1
10 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.56 EXT2 EXT1
11 endochondral bone morphogenesis GO:0060350 9.33 EXT2 EXT1
12 fluid transport GO:0042044 9.26 EXT2 EXT1
13 cellular polysaccharide biosynthetic process GO:0033692 8.92 EXT2 EXT1

Molecular functions related to Periosteal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.86 H3-3B H3-3A EXT2 EXT1
2 glucuronosyltransferase activity GO:0015020 9.71 EXT2 EXT1
3 acetylglucosaminyltransferase activity GO:0008375 9.67 EXT2 EXT1
4 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.62 H3-3B H3-3A
5 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 9.46 EXT2 EXT1
6 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 9.26 EXT2 EXT1
7 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 8.92 EXT2 EXT1

Sources for Periosteal Osteogenic Sarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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