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MCID: PRS037
MIFTS: 38

Periostitis

Categories: Bone diseases
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Aliases & Classifications for Periostitis

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MalaCards integrated aliases for Periostitis:

Name: Periostitis 11 43 14 71 75

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 31


External Ids:

Disease Ontology 11 DOID:9957
MeSH 43 D010522
SNOMED-CT 68 41910004
ICD10 31 M90.1
UMLS 71 C0031111
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Summaries for Periostitis

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Disease Ontology: 11 A connective tissue disease characterized by inflammation located in the periosteum of the bone.

MalaCards based summary: Periostitis is related to alveolar periostitis and psoriasis 14, pustular. An important gene associated with Periostitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. Affiliated tissues include periosteum of the bone, bone and lung, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia: 75 Periostitis, also known as periostalgia, is a medical condition caused by inflammation of the... more...
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Related Diseases for Periostitis

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Diseases related to Periostitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 498)
# Related Disease Score Top Affiliating Genes
1 alveolar periostitis 32.3 TNF CRP
2 psoriasis 14, pustular 30.9 TNF IL36RN IL1RL2 IL1F10
3 secondary syphilis 30.3 TNF CRP
4 interstitial keratitis 30.2 TNF CRP
5 paget disease of bone 2, early-onset 30.2 TNFRSF11A SQSTM1
6 paget disease of bone 5, juvenile-onset 30.2 TNFRSF11B TNFRSF11A
7 spondyloarthropathy 1 30.0 TNFRSF11B TNF IL1RN IL1B CRP
8 familial expansile osteolysis 30.0 TNFRSF11B TNFRSF11A SQSTM1
9 mammary paget's disease 30.0 TNFRSF11B TNFRSF11A SQSTM1
10 paget's disease of bone 30.0 TNFRSF11B TNFRSF11A SQSTM1
11 osteomyelitis 30.0 TNFRSF11A TNF LPIN2 IL1RN IL1B IL1A
12 bone inflammation disease 29.9 TNF IL1B IL1A CRP
13 aspergillosis 29.9 TNF IL1RN IL1B IL1A
14 optic papillitis 29.9 TNF CRP
15 typhoid fever 29.8 TNF IL1B IL1A CRP
16 pericoronitis 29.8 TNF IL1B CRP
17 actinomycosis 29.8 TNF CRP
18 cellulitis 29.8 TNF IL1B CRP
19 meningoencephalitis 29.8 TNF IL1B CRP
20 psoriatic arthritis 29.8 TNFRSF11B TNF IL1RN IL1B IL1A CRP
21 myelofibrosis 29.7 TNFRSF11B TNF IL1B CRP
22 chronic recurrent multifocal osteomyelitis 29.6 TNF PSTPIP2 PSTPIP1 LPIN2 IL1RN IL1B
23 arthropathy 29.6 TNFRSF11B TNFRSF11A TNF IL1RN IL1B CRP
24 sapho syndrome 29.6 TNF PSTPIP2 PSTPIP1 LPIN2 IL1RN CRP
25 smallpox 29.6 TNF IL1RN IL1B
26 bone disease 29.6 TNFRSF11B TNFRSF11A TNF IL11 ALPP
27 pulmonary tuberculosis 29.6 TNF IL1B CRP
28 anterior uveitis 29.6 TNF IL1B CRP
29 exanthem 29.5 TNF IL1B CRP
30 appendicitis 29.5 TNF IL1B CRP
31 lung disease 29.5 TNF IL1RN IL1B IL1A
32 pericarditis 29.5 TNF IL1B CRP
33 bowel dysfunction 29.5 TNF IL1B CRP
34 periapical periodontitis 29.5 TNF IL1B IL1A
35 bronchiolitis 29.4 TNF IL1B IL11 CRP
36 sarcoidosis 1 29.4 TNF IL1RN IL1B IL1A CRP
37 pleurisy 29.4 TNF IL1RN IL1B CRP
38 temporal arteritis 29.4 TNF IL1RN IL1B CRP
39 osteoarthritis 29.3 TNFRSF11B TNF IL1RN IL1B IL1A CRP
40 ulcerative colitis 29.3 TNF IL1RN IL1B CRP
41 erythema nodosum 29.3 TNF IL1RN IL1B IL1A CRP
42 periodontitis 29.3 TNF IL1RN IL1B IL1A CRP
43 meningitis 29.2 TNF IL1B IL1A CRP
44 pharyngitis 29.2 TNF MVK IL1B CRP
45 synovitis 29.1 TNFRSF11B TNF IL1RN IL1B IL1A CRP
46 psoriasis 29.1 TNF IL36RN IL1B IL1A IL11
47 psoriasis 11 29.1 IL36RN IL1RL2 IL1F10 IL1A
48 thrombocytopenia 29.1 TNF IL1RN IL1B IL1A IL11 CRP
49 autoimmune disease 29.1 TNF IL1RN IL1B IL1A CRP
50 juvenile rheumatoid arthritis 29.0 TNF IL1RN IL1B IL1A CRP

Graphical network of the top 20 diseases related to Periostitis:



Diseases related to Periostitis
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Symptoms & Phenotypes for Periostitis

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GenomeRNAi Phenotypes related to Periostitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.1 ALPP CRP HPGD IL11 IL1A IL1B
2 no effect GR00402-S-2 10.1 ALPP CRP HPGD IL1A IL1B IL1RL2

MGI Mouse Phenotypes related to Periostitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 CRP HPGD IL1A IL1B IL1RL2 IL1RN
2 immune system MP:0005387 10 CRP IL1A IL1B IL1F10 IL1RL2 IL1RN
3 hematopoietic system MP:0005397 9.73 IL1A IL1B IL1RL2 IL1RN IL36RN LPIN2
4 integument MP:0010771 9.32 IL1A IL1B IL1RL2 IL1RN IL36RN PSTPIP2
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Drugs & Therapeutics for Periostitis

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Search Clinical Trials, NIH Clinical Center for Periostitis

Cochrane evidence based reviews: periostitis

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Genetic Tests for Periostitis

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Anatomical Context for Periostitis

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Organs/tissues related to Periostitis:

FMA: Periosteum Of The Bone
MalaCards : Bone, Lung, Bone Marrow, Thymus, Liver, Small Intestine, Heart
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Publications for Periostitis

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Articles related to Periostitis:

(show top 50) (show all 955)
# Title Authors PMID Year
1
Musculoskeletal manifestations of syphilis in adults: secondary syphilis presenting with ankle inflammatory arthritis and bone involvement with calvarial and sternal lesions. What the rheumatologist needs to know. 62
36454341 2022
2
Spectrum of voriconazole-associated periostitis in clinical characteristics, diagnosis and management. 62
35288847 2022
3
Voriconazole-Induced Diffuse Periostitis. 62
36189133 2022
4
Radiation-induced osteoradionecrosis of the ribs in a patient with breast cancer: A case report. 62
35721524 2022
5
A Novel Physical Therapy Approach in Pain Management and Enhancement of Performance in Shin Splints Athletes: A Case Report. 62
35949752 2022
6
Clinical Images: Voriconazole-induced synovitis, enthesitis, and periostitis. 62
35137565 2022
7
Chronic venous disease. Part 1: pathophysiology and clinical features. 62
35167156 2022
8
[Bilateral periostitis and arthritis: about a case of hypertrophic osteoarthropathy]. 62
35924493 2022
9
Voriconazole-induced periostitis post lung transplantation. 62
35309380 2022
10
An ancient cranium from Dmanisi: Evidence for interpersonal violence, disease, and possible predation by carnivores on Early Pleistocene Homo. 62
35367913 2022
11
Enlarged Reactional Periostitis of the Peroneal Tubercle Mimicking Osteochondromatosis of the Calcaneus: A Case Report. 62
35774645 2022
12
Simultaneous ocular and osseous syphilis: a case report. 62
34586244 2022
13
Iliac periostitis revealing acute leukemia. 62
35124212 2022
14
Voriconazole-Induced Periostitis in a Transplant Patient. 62
35325905 2022
15
Florid Reactive Periostitis of the Clavicle: A Case Report. 62
36237924 2022
16
Recurrent osteomyelitis with proliferative periostitis after segmental resection and reconstruction of the mandible: a case report. 62
35296946 2022
17
Recurrent Tibial Periostitis Due to Blunt Trauma. 62
35156055 2022
18
Voriconazole-Associated Periostitis: New Insights into Pathophysiology and Management. 62
35229058 2022
19
Prostaglandin E1-induced periostitis in a neonate with congenital heart disease. 62
36134666 2022
20
Chronic Osteomyelitis With Proliferative Periostitis of the Mandible in a Child: Report of a Case Managed by Immunosuppressive Treatment. 62
34711782 2022
21
Osteolytic bone lesions in patients with primary myelofibrosis: A systematic review. 62
35075062 2022
22
A Systematic Approach to Diagnosing Arthritis Based on Radiological Imaging. 62
36062867 2022
23
Magnetic resonance imaging of musculoskeletal infections. 62
35505859 2022
24
Some Reactive Lesions of Bone Are Probably Neoplasms. 62
33946096 2022
25
Association of Inflammatory Periapical Lesions with Maxillary Sinus Abnormalities: a Retrospective Cone-Beam Computed Tomography Study. 62
34904124 2021
26
Focal reactive periostitis ossificans in a long bone: radiologic and pathologic findings. 62
34630790 2021
27
Psoriatic onycho-pachydermo periostitis (POPP): a case report treated successfully with IL-17 blockade and a literature review on characteristics, pathogenesis, and treatment. 62
33830360 2021
28
Garré's Sclerosing Osteomyelitis with Perimandibular Soft Tissue Inflammation and Fistula. 62
35136519 2021
29
Endobronchial actinomycosis in a child. 62
34265174 2021
30
A rare clinical entity: Florid reactive periostitis. Case report and literature review. 62
33971292 2021
31
Pseudoparalysis of parrot - Re-emergence of the great mimicker. 62
33892938 2021
32
Voriconazole-associated periostitis: Pathophysiology, risk factors, clinical manifestations, diagnosis, and management. 62
34631468 2021
33
Editorial Comment on "Fibular Tip Periostitis: New Radiographic Sign Predictive of Chronic Peroneal Tendon Subluxation-Dislocation in Pes Planovalgus". 62
32997509 2021
34
Fibular Tip Periostitis: New Radiographic Sign Predictive of Chronic Peroneal Tendon Subluxation-Dislocation in Pes Planovalgus. 62
32936017 2021
35
Osteolytic lesions in myelofibrosis. 62
34295475 2021
36
Recalcitrant psoriatic onycho-pachydermo-periostitis successfully treated with guselkumab. 62
33619743 2021
37
Diagnostic Challenge Involving Diffuse Mandibular Swelling in Mixed Dentition: Use of Cone-beam Radiography. 62
34720520 2021
38
Costal Osteoma: Report of a Case in an Unusual Site. 62
33864678 2021
39
Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion) in Pediatric Phalanges. 62
32611484 2021
40
Identification of Serum miR-337-3p, miR-484, miR-582, and miR-3677 as Promising Biomarkers for Osteosarcoma. 62
33865271 2021
41
Voriconazole-induced periostitis. 62
33874646 2021
42
Advantage of Hybrid 18F-Fluoride Positron Emission Tomography/Computed Tomography to Diagnose Malignant Rib Invasion by Pleural Metastasis in a Background of Reactive Periostitis. 62
34385805 2021
43
Psoriatic onycho-pachydermo-periostitis: a patient's perspective. 62
32918490 2021
44
Osseous lesions in the distal extremities of dogs with strangulating hair mats. 62
33184951 2021
45
Actinomycotic osteomyelitis with proliferative periostitis arising in the mandibular ramus: an unusual case with spontaneous bone regeneration after coronoidectomy. 62
32607939 2021
46
Bizarre parosteal osteochondromatous proliferation: Rare case affecting distal ulna and review of literature. 62
32977195 2021
47
Histological Evaluation of the Relationships Between Distal Interphalangeal Psoriatic Arthritis and Nail Psoriasis: Correlations With Anatomical Studies of the Normal Nail Unit and the Main Radiological Data Concerning Distal Interphalangeal Psoriatic Arthritis. 62
32889808 2020
48
Correction to: Voriconazole-induced periostitis in stem cell transplant patient. 62
32562086 2020
49
Voriconazole-induced periostitis in stem cell transplant patient. 62
32430648 2020
50
Diagnostic accuracy of MRI with metal artifact reduction for the detection of periprosthetic joint infection and aseptic loosening of total hip arthroplasty. 62
32937252 2020
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Variations for Periostitis

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Expression for Periostitis

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Search GEO for disease gene expression data for Periostitis.
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Pathways for Periostitis

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Pathways related to Periostitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.77 TNFRSF11B TNFRSF11A TNF SQSTM1 PSTPIP1 IL36RN
2
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.48 IL11 IL1A IL1B IL1F10 IL1RN IL36RN
3
TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions 65
Show member pathways
 12.48 TNFRSF11B TNFRSF11A TNF IL1B IL1A
4
NF-kappaB Signaling 3
12.44 TNFRSF11A TNF IL1RN IL1B
5
Cytokine Signaling in Immune system 66
Show member pathways
 12.44 TNFRSF11B TNFRSF11A TNF SQSTM1 IL36RN IL1RN
6
IL-1 Family Signaling Pathways 65
Show member pathways
 12.42 IL1A IL1B IL1F10 IL1RL2 IL1RN IL36RN
7
Bacterial infections in CF airways 22
Show member pathways
 12.31 TNF SQSTM1 IL1RN IL1B IL1A IL11
8
Interleukin-1 family signaling 66
Show member pathways
 12.25 SQSTM1 IL36RN IL1RN IL1RL2 IL1F10 IL1B
9
Sudden infant death syndrome (SIDS) susceptibility pathways 74
12.01 TNF IL1RN IL1B IL1A
10
Spinal cord injury 74
11.87 TNF IL1B IL1A
11
Interleukin-4 and Interleukin-13 signaling 66
11.83 TNF IL1B IL1A
12
Senescence and autophagy in cancer 74
11.81 SQSTM1 IL1B IL1A
13
Inflammasomes 66
Show member pathways
 11.8 PSTPIP1 IL1B IL1A
14
Allograft rejection 74
11.74 TNF IL1B IL1A
15
Clock-controlled autophagy in bone metabolism 74
11.67 TNFRSF11B TNFRSF11A SQSTM1
16
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.61 TNFRSF11A TNF SQSTM1
17
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.53 TNF IL1B IL1A
18
IL 10 signaling pathway 67
11.52 TNF IL1B IL1A
19
Interleukin-10 signaling 66
11.43 IL1A IL1B IL1RN TNF
20
Monoamine transport 74
Show member pathways
 11.33 TNFRSF11B TNF IL1B
21
IL-10 Pathway 64
11.21 TNF IL1B IL1A
22
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.21 TNFRSF11B TNFRSF11A TNF IL1B IL1A
23
Cytokines and inflammatory response 74
11.13 TNF IL1B IL1A IL11
24
Prostaglandin signaling 74
11.1 TNF IL1B IL1A
25
2q13 copy number variation syndrome 74
10.97 IL36RN IL1RN IL1F10 IL1B IL1A
26
LDL Oxidation in Atherogenesis 64
10.83 TNF IL1B
27
Interleukin-1 induced activation of NF-kB 74
10.54 SQSTM1 IL1A
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GO Terms for Periostitis

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Cellular components related to Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.6 TNFRSF11B TNF IL36RN IL1RN IL1F10 IL1B

Biological processes related to Periostitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.16 IL1A IL1B IL1F10 IL1RN IL36RN TNF
2 cytokine-mediated signaling pathway GO:0019221 10.09 IL1RL2 IL1F10 IL1B IL1A
3 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.95 TNF IL1B IL1A
4 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.93 TNF SQSTM1 IL1B
5 positive regulation of interleukin-6 production GO:0032755 9.92 TNF IL1RL2 IL1B IL1A
6 positive regulation of mitotic nuclear division GO:0045840 9.91 TNF IL1B IL1A
7 vascular endothelial growth factor production GO:0010573 9.86 TNF IL1B
8 positive regulation of immature T cell proliferation in thymus GO:0033092 9.84 IL1B IL1A
9 positive regulation of fever generation GO:0031622 9.83 TNF IL1B
10 cellular response to lipopolysaccharide GO:0071222 9.81 IL1A IL1B IL1F10 IL36RN TNF
11 sequestering of triglyceride GO:0030730 9.8 TNF IL1B
12 inflammatory response to antigenic stimulus GO:0002437 9.73 IL36RN IL1RN IL1F10
13 fever generation GO:0001660 9.71 IL1A IL1B
14 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.67 IL1B TNF
15 inflammatory response GO:0006954 9.58 TNF PSTPIP1 IL36RN IL1RN IL1RL2 IL1F10
16 response to lipopolysaccharide GO:0032496 9.56 TNFRSF11A TNF IL1B IL1A HPGD

Molecular functions related to Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.86 TNFRSF11B TNF IL36RN IL1RN IL1F10 IL1B
2 interleukin-1 receptor antagonist activity GO:0005152 9.46 IL36RN IL1RN
3 interleukin-1 receptor binding GO:0005149 9.28 IL36RN IL1RN IL1F10 IL1B IL1A
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Sources for Periostitis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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