MCID: PRP009
MIFTS: 53

Peripartum Cardiomyopathy

Categories: Rare diseases, Reproductive diseases, Cardiovascular diseases

Aliases & Classifications for Peripartum Cardiomyopathy

MalaCards integrated aliases for Peripartum Cardiomyopathy:

Name: Peripartum Cardiomyopathy 57 76 53 59 73
Postpartum Cardiomyopathy 53 59 73
Peripartum Cardiomyopathy, Susceptibility to 57
Cardiomyopathy, Peripartum 40
Ppcm, Susceptibility to 57
Meadows' Syndrome 53
Ppcm 57

Characteristics:

Orphanet epidemiological data:

59
peripartum cardiomyopathy
Age of onset: Adult;

Classifications:



External Ids:

OMIM 57 614670
Orphanet 59 ORPHA563
UMLS via Orphanet 74 C0877208 C0269972
ICD10 via Orphanet 34 O90.3
UMLS 73 C0269972

Summaries for Peripartum Cardiomyopathy

OMIM : 57 Peripartum cardiomyopathy (PPCM) is characterized by systolic heart failure presenting in the last month of pregnancy or the first 5 months postpartum. PPCM affects 1 in 300 to 1 in 3,000 pregnancies, with geographic hot spots of high incidence, such as Nigeria and Haiti. Although approximately half of affected women recover cardiac function postpartum, many patients progress to chronic heart failure, cardiac transplantation, or death. Data have suggested that antiangiogenic prolactin (176760) fragments may have an important role in causing the disease in some patients. Risk factors for PPCM also include preeclampsia (see 189800) and multiple gestation, suggesting a potential mechanistic overlap with these processes (summary by Patten et al., 2012). (614670)

MalaCards based summary : Peripartum Cardiomyopathy, also known as postpartum cardiomyopathy, is related to left ventricular noncompaction and cardiac conduction defect. An important gene associated with Peripartum Cardiomyopathy is PRL (Prolactin), and among its related pathways/superpathways are Circadian entrainment and G-Beta Gamma Signaling. The drugs Selenious acid and Selenium have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and cardiac myocytes, and related phenotypes are cardiovascular system and homeostasis/metabolism

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 563Disease definitionPeripartum cardiomyopathy (PPCM) is an idiopathic, potentially fatal form of dilated cardiomyopathy that develops during the final month of pregnancy or within five months after delivery.Visit the Orphanet disease page for more resources.

Wikipedia : 76 Peripartum cardiomyopathy (PPCM) is a form of dilated cardiomyopathy that is defined as a deterioration... more...

Related Diseases for Peripartum Cardiomyopathy

Diseases related to Peripartum Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 left ventricular noncompaction 30.1 MYH7 SCN5A TTN
2 cardiac conduction defect 29.4 MYH7 SCN5A
3 syncope 29.2 GNB3 SCN5A TTN
4 dilated cardiomyopathy 28.9 ADRB1 CHRM2 MYH7 PDCD1 SCN5A TTN
5 transmitted_by 11.4
6 galactorrhea 10.6 DRD2 PRL
7 meningeal melanomatosis 10.6 NRAS PDCD1
8 schizophreniform disorder 10.5 DRD2 PRL
9 prolactin producing pituitary tumor 10.5 DRD2 PRL
10 social phobia 10.5 DRD2 PRL
11 first-degree atrioventricular block 10.4 MYH7 SCN5A
12 ovarian cyst 10.2 PRL VEGFA
13 adenomyosis 10.2 PRL VEGFA
14 pre-eclampsia 10.1
15 vulvar melanoma 10.1 CD274 NRAS
16 lymphoepithelioma-like carcinoma 10.1 CD274 PDCD1
17 eclampsia 10.1
18 cardiomyopathy, dilated, 1e 10.1 MYH7 SCN5A TTN
19 familial isolated dilated cardiomyopathy 10.1 MYH7 SCN5A TTN
20 angiokeratoma circumscriptum 10.1 FLT1 VEGFA
21 intrinsic cardiomyopathy 10.1 MYH7 SCN5A TTN
22 cardiac arrest 10.0
23 glomeruloid hemangioma 10.0 FLT1 VEGFA
24 hyperprolactinemia 10.0
25 pulmonary edema 10.0
26 heart disease 10.0
27 myocarditis 10.0
28 pulmonary embolism 10.0
29 multiple endocrine neoplasia 10.0
30 cardiogenic shock 10.0
31 microcystic meningioma 10.0 FLT1 VEGFA
32 epithelioid hemangioendothelioma 9.9 FLT1 VEGFA
33 human immunodeficiency virus type 1 9.9
34 multiple endocrine neoplasia, type i 9.9
35 systemic lupus erythematosus 9.9
36 cardiomyopathy, dilated, 1b 9.9
37 ventricular fibrillation, paroxysmal familial, 1 9.9
38 muscular dystrophy, congenital, 1b 9.9
39 myocardial infarction 9.9
40 ventricular septal defect 9.9
41 lupus erythematosus 9.9
42 lipodermatosclerosis 9.9 FLT1 VEGFA
43 cancer-associated retinopathy 9.8 FLT1 VEGFA
44 functioning pituitary adenoma 9.8 DRD2 PRL
45 atrial standstill 1 9.8 ADRB1 MYH7 SCN5A TTN
46 autoimmune disease 9.7
47 progressive familial heart block, type ia 9.7
48 klippel-trenaunay-weber syndrome 9.7
49 schizophrenia 9.7
50 wolff-parkinson-white syndrome 9.7

Graphical network of the top 20 diseases related to Peripartum Cardiomyopathy:



Diseases related to Peripartum Cardiomyopathy

Symptoms & Phenotypes for Peripartum Cardiomyopathy

Clinical features from OMIM:

614670

MGI Mouse Phenotypes related to Peripartum Cardiomyopathy:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 RELA SCN5A TTN VEGFA ADRB1 CHRM2
2 homeostasis/metabolism MP:0005376 10.24 VEGFA ADRB1 CD274 CHRM2 DRD2 FLT1
3 growth/size/body region MP:0005378 10.21 TTN VEGFA ADRB1 CHRM2 DRD2 FLT1
4 behavior/neurological MP:0005386 10.19 CD274 CHRM2 DRD2 FLT1 NRAS PRL
5 mortality/aging MP:0010768 10.14 TTN VEGFA ADRB1 CD274 DRD2 FLT1
6 immune system MP:0005387 10.13 CD274 DRD2 FLT1 NRAS PDCD1 PRL
7 muscle MP:0005369 10.07 ADRB1 CHRM2 DRD2 FLT1 MYH7 PDCD1
8 integument MP:0010771 10 CD274 CHRM2 DRD2 NRAS PRL RELA
9 liver/biliary system MP:0005370 9.98 CHRM2 DRD2 NRAS PDCD1 PRL RELA
10 nervous system MP:0003631 9.97 VEGFA CHRM2 DRD2 FLT1 GNB3 PDCD1
11 no phenotypic analysis MP:0003012 9.73 ADRB1 CD274 DRD2 MYH7 NRAS VEGFA
12 normal MP:0002873 9.7 DRD2 FLT1 NRAS RELA SCN5A TTN
13 skeleton MP:0005390 9.56 ADRB1 CD274 DRD2 NRAS PDCD1 RELA
14 vision/eye MP:0005391 9.23 CHRM2 FLT1 GNB3 NRAS PDCD1 RELA

Drugs & Therapeutics for Peripartum Cardiomyopathy

Drugs for Peripartum Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenious acid Approved, Investigational Phase 4 7783-00-8
2
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
3 Antioxidants Phase 4
4 Micronutrients Phase 4
5 Protective Agents Phase 4
6 Sodium Selenite Phase 4
7 Trace Elements Phase 4
8
Bromocriptine Approved, Investigational Phase 3,Phase 2 25614-03-3 31101
9
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
10
Dalteparin Approved Phase 3 9005-49-6
11
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
12 Antiparkinson Agents Phase 3,Phase 2
13 Dopamine Agents Phase 3,Phase 2
14 Dopamine agonists Phase 3,Phase 2
15 Hormone Antagonists Phase 3,Phase 2
16 Hormones Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
18 Neurotransmitter Agents Phase 3,Phase 2
19 calcium heparin Phase 3
20 Heparin, Low-Molecular-Weight Phase 3
21 Angiotensin-Converting Enzyme Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Peripartum Cardiomyopathy in Nigeria Registry Recruiting NCT03081949 Phase 4 Oral Sodium Selenite 200 µg/day for 3 months
2 Bromocriptine in the Treatment of Peripartum Cardiomyopathy Recruiting NCT02590601 Phase 3 Bromocriptine
3 Effect of Bromocriptine on Left Ventricular Function in Women With Peripartum Cardiomyopathy Completed NCT00998556 Phase 2 Bromocriptine
4 Registry and Survey of Women With Pregnancy Related Cardiomyopathy Unknown status NCT00273637
5 Investigation in Pregnancy Associate Cardiomyopathy Completed NCT01085955
6 The Study of Cardiovascular Outcomes in Women With Preeclampsia Using Echocardiography: The SCOPE Study Completed NCT02357667
7 A Registry of Peripartum Cardiomyopathy in Turkey Recruiting NCT03364140
8 Pregnancy and Dilated Cardiomyopathy Recruiting NCT03235063

Search NIH Clinical Center for Peripartum Cardiomyopathy

Genetic Tests for Peripartum Cardiomyopathy

Anatomical Context for Peripartum Cardiomyopathy

MalaCards organs/tissues related to Peripartum Cardiomyopathy:

41
Heart, T Cells, Cardiac Myocytes, Neutrophil, Monocytes, Testes, Liver

Publications for Peripartum Cardiomyopathy

Articles related to Peripartum Cardiomyopathy:

(show top 50) (show all 608)
# Title Authors Year
1
A Case Report of Recurrent Severe Peripartum Cardiomyopathy Complicated by Factor V Leiden and Multiple Endocrine Neoplasia Type 1: A Management Conundrum. ( 29652683 )
2018
2
Bromocriptine for the Treatment of Peripartum Cardiomyopathy. ( 29892477 )
2018
3
Cardiogenic shock complicating peripartum cardiomyopathy: Importance of early left ventricular unloading and bromocriptine therapy. ( 29792513 )
2018
4
The rationale and design of the national peripartum cardiomyopathy registries in Turkey: The ARTEMIS-I and ARTEMIS-II studies. ( 29339690 )
2018
5
Maternal and fetal prognosis of subsequent pregnancy in black African women with peripartum cardiomyopathy. ( 29914408 )
2018
6
Peripartum Cardiomyopathy and Preeclampsia: Overlapping Diseases of Pregnancy. ( 29971645 )
2018
7
Psychological adaptation after peripartum cardiomyopathy: A qualitative study. ( 29655005 )
2018
8
Etiologies, Predictors, and Economic Impact of 30-Day Readmissions Among Patients With Peripartum Cardiomyopathy. ( 29703438 )
2018
9
June 2018 at a glance: peripartum cardiomyopathy and pathophysiology, prognosis, and device therapy of heart failure. ( 29870145 )
2018
10
A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. ( 29761889 )
2018
11
Anomalous Left Coronary Artery From the Pulmonary Artery: Masquerading as Peripartum Cardiomyopathy. ( 29530774 )
2018
12
Peripartum cardiomyopathy: A systematic review of the literature. ( 29749620 )
2018
13
Predictors of early and delayed recovery in peripartum cardiomyopathy: A prospective study of 52 patients. ( 29945487 )
2018
14
Clinical Profile and Outcome of Peripartum Cardiomyopathy - A Study in a Tertiary Cardiac Hospital of Bangladesh. ( 29769494 )
2018
15
Arrhythmic manifestation of peripartum cardiomyopathy-Case report. ( 29667277 )
2018
16
Initial Right Ventricular Dysfunction Severity Identifies Severe Peripartum Cardiomyopathy Phenotype With Worse Early and Overall Outcomes: A 24-Year Cohort Study. ( 29686029 )
2018
17
Successful management of fatal peripartum cardiomyopathy in a young pregnant woman: A case report. ( 29642207 )
2018
18
Peripartum cardiomyopathy: Status 2018. ( 29451958 )
2018
19
Anticoagulation Therapy in Specific Cardiomyopathies: Isolated Left Ventricular Noncompaction and Peripartum Cardiomyopathy. ( 29911432 )
2018
20
New Insights in Peripartum Cardiomyopathy. ( 29747731 )
2018
21
When baby 'pushed the button': an exceptional peripartum cardiomyopathy-like syndrome. ( 29931056 )
2018
22
Peripartum Serial Echocardiographic Findings in a Patient with Life-threatening Peripartum Cardiomyopathy. ( 29877258 )
2018
23
Subsequent Pregnancy Outcomes in Patients With Peripartum Cardiomyopathy. ( 29324614 )
2018
24
Peripartum cardiomyopathy. ( 29767811 )
2018
25
Circulating T-Cell Subsets, Monocytes, and Natural Killer Cells in Peripartum Cardiomyopathy: Results From the Multicenter IPAC Study. ( 29079307 )
2018
26
The Role of Genetics in Peripartum Cardiomyopathy. ( 28776299 )
2017
27
Peripartum cardiomyopathy: diagnosis and management. ( 29122930 )
2017
28
Peripartum cardiomyopathy in Denmark: a retrospective, population-based study of incidence, management and outcome. ( 28597481 )
2017
29
Peripartum cardiomyopathy is associated with increased uric acid concentrations: A population based study. ( 28779903 )
2017
30
December 2017 at a glance: left ventricular ejection fraction, exercise capacity, peripartum cardiomyopathy. ( 29271589 )
2017
31
Peripartum cardiomyopathy, what if your patient plans to reconceive? ( 28588804 )
2017
32
Understanding Peripartum Cardiomyopathy. ( 28813232 )
2017
33
A Case Report of Recurrent Severe Peripartum Cardiomyopathy Complicated by Factor V Leiden and Multiple Endocrine Neoplasia Type 1: A Management Conundrum. ( 29077664 )
2017
34
Myocardial Recovery in Peripartum Cardiomyopathy After Hyperprolactinemia Treatment on BIVAD. ( 27748657 )
2017
35
Bromocriptine for the treatment of peripartum cardiomyopathy: welcome on BOARD. ( 28934838 )
2017
36
Outcomes and mortality in parturient and non-parturient patients with peripartum cardiomyopathy: A national readmission database study. ( 29153668 )
2017
37
Peripartum Cardiomyopathy: Do Exosomes Play a Role? ( 28936737 )
2017
38
Understanding the association between hypertensive disorders of pregnancy and peripartum cardiomyopathy. ( 28891239 )
2017
39
Peripartum cardiomyopathy for the clinician: the known and the unknown. ( 28653358 )
2017
40
Re: Myocardial Recovery in Peripartum Cardiomyopathy after Hyperprolactinemia Treatment on Biventricular Assist Device. ( 28114195 )
2017
41
Value of the neutrophil-to-lymphocyte ratio in predicting left ventricular recovery in patients with peripartum cardiomyopathy. ( 28702739 )
2017
42
Vasoinhibin Serum Levels Are Required to Demonstrate Their Role in Peripartum Cardiomyopathy Etiopathology. ( 28657930 )
2017
43
Subsequent reproductive outcome among women with peripartum cardiomyopathy: a nationwide study. ( 29211333 )
2017
44
Peripartum Cardiomyopathy in Cardiac MRI: A Case Report. ( 27846644 )
2017
45
A contemporary review of peripartum cardiomyopathy. ( 28765406 )
2017
46
Myofilament remodeling and function is more impaired in peripartum cardiomyopathy compared to dilated cardiomyopathy and ischemic heart disease. ( 28935576 )
2017
47
Poor Outcomes in Poor Patients?: Peripartum Cardiomyopathy-Not Just Black and White. ( 29049487 )
2017
48
Prophylactic use of an intra-aortic balloon pump in a high-risk patient with peripartum cardiomyopathy requiring cesarean delivery. ( 28802997 )
2017
49
Peripartum cardiomyopathy, place of drug therapy, assist devices, and outcome after left ventricular assistance. ( 27776335 )
2017
50
Comparison of Clinical Characteristics and Outcomes of Peripartum Cardiomyopathy Between African American and Non-African American Women. ( 29049825 )
2017

Variations for Peripartum Cardiomyopathy

Expression for Peripartum Cardiomyopathy

Search GEO for disease gene expression data for Peripartum Cardiomyopathy.

Pathways for Peripartum Cardiomyopathy

Pathways related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 CHRM2 DRD2 GNB3 NRAS RELA VEGFA
2
Show member pathways
12.67 ADRB1 DRD2 GNB3 NRAS SCN5A VEGFA
3
Show member pathways
12.34 GNB3 NRAS RELA VEGFA
4
Show member pathways
12.07 DRD2 FLT1 GNB3 NRAS RELA VEGFA
5
Show member pathways
12.06 ADRB1 CHRM2 DRD2 RELA
6
Show member pathways
12 NRAS RELA VEGFA
7
Show member pathways
11.99 CHRM2 FLT1 GNB3 NRAS PRL RELA
8
Show member pathways
11.77 ADRB1 CHRM2 DRD2
9 11.77 CHRM2 GNB3 SCN5A VEGFA
10 11.69 FLT1 RELA VEGFA
11 11.67 NRAS RELA VEGFA
12 11.6 ADRB1 DRD2 NRAS
13 11.36 ADRB1 CHRM2 SCN5A
14 11.26 NRAS RELA VEGFA
15 11 FLT1 VEGFA
16 10.96 FLT1 VEGFA
17 10.96 FLT1 NRAS VEGFA
18 10.9 NRAS RELA
19
Show member pathways
10.75 FLT1 VEGFA

GO Terms for Peripartum Cardiomyopathy

Cellular components related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle myosin complex GO:0005859 8.96 MYH7 TTN
2 Z disc GO:0030018 8.8 MYH7 SCN5A TTN

Biological processes related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 striated muscle contraction GO:0006941 9.52 MYH7 TTN
2 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.49 PRL RELA
3 positive regulation of receptor internalization GO:0002092 9.48 DRD2 VEGFA
4 temperature homeostasis GO:0001659 9.46 ADRB1 DRD2
5 positive regulation of neuroblast proliferation GO:0002052 9.43 DRD2 VEGFA
6 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.4 MIR146A VEGFA
7 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.37 FLT1 VEGFA
8 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 9.33 ADRB1 CHRM2 DRD2
9 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.32 ADRB1 DRD2
10 cardiac muscle fiber development GO:0048739 9.26 TTN VEGFA
11 cardiac muscle contraction GO:0060048 9.13 MYH7 SCN5A TTN
12 regulation of heart rate GO:0002027 8.8 DRD2 MYH7 SCN5A
13 signal transduction GO:0007165 10.05 ADRB1 CD274 CHRM2 DRD2 GNB3 NRAS

Molecular functions related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer activity GO:0004871 9.46 ADRB1 DRD2 GNB3 PDCD1
2 adrenergic receptor activity GO:0004935 8.96 ADRB1 DRD2
3 actinin binding GO:0042805 8.62 RELA TTN

Sources for Peripartum Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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