PPCM
MCID: PRP009
MIFTS: 54

Peripartum Cardiomyopathy (PPCM)

Categories: Blood diseases, Cardiovascular diseases, Muscle diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Peripartum Cardiomyopathy

MalaCards integrated aliases for Peripartum Cardiomyopathy:

Name: Peripartum Cardiomyopathy 57 12 73 20 58 15 17 70
Postpartum Cardiomyopathy 20 58 70
Peripartum Cardiomyopathy, Susceptibility to 57
Antepartum Peripartum Cardiomyopathy 12
Postpartum Peripartum Cardiomyopathy 12
Cardiomyopathy, Peripartum 39
Ppcm, Susceptibility to 57
Meadows' Syndrome 20
Ppcm 57

Characteristics:

Orphanet epidemiological data:

58
peripartum cardiomyopathy
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


Summaries for Peripartum Cardiomyopathy

OMIM® : 57 Peripartum cardiomyopathy (PPCM) is characterized by systolic heart failure presenting in the last month of pregnancy or the first 5 months postpartum. PPCM affects 1 in 300 to 1 in 3,000 pregnancies, with geographic hot spots of high incidence, such as Nigeria and Haiti. Although approximately half of affected women recover cardiac function postpartum, many patients progress to chronic heart failure, cardiac transplantation, or death. Data have suggested that antiangiogenic prolactin (176760) fragments may have an important role in causing the disease in some patients. Risk factors for PPCM also include preeclampsia (see 189800) and multiple gestation, suggesting a potential mechanistic overlap with these processes (summary by Patten et al., 2012). (614670) (Updated 05-Apr-2021)

MalaCards based summary : Peripartum Cardiomyopathy, also known as postpartum cardiomyopathy, is related to atrial standstill 1 and systolic heart failure. An important gene associated with Peripartum Cardiomyopathy is MIR146A (MicroRNA 146a), and among its related pathways/superpathways are G-Beta Gamma Signaling and PI3K-Akt signaling pathway. The drugs Selenious acid and Selenium have been mentioned in the context of this disorder. Affiliated tissues include heart, thyroid and brain, and related phenotypes are hypertension and fatigue

Disease Ontology : 12 A dilated cardiomyopathy that is characterized by a weakness of the heart muscle that begins sometime during the final month of pregnancy through about five months after delivery.

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 563 Definition Peripartum cardiomyopathy (PPCM) is an idiopathic, potentially fatal form of dilated cardiomyopathy that develops during the final month of pregnancy or within five months after delivery.

Wikipedia : 73 Peripartum cardiomyopathy (PPCM) is a form of dilated cardiomyopathy that is defined as a deterioration... more...

Related Diseases for Peripartum Cardiomyopathy

Diseases related to Peripartum Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 304)
# Related Disease Score Top Affiliating Genes
1 atrial standstill 1 31.9 TTN SCN5A MYH7 ADRB1 ACE
2 systolic heart failure 31.2 TTN ADRB1 ACE
3 eclampsia 31.0 VEGFA PGF FLT1 ACE
4 cardiac arrest 30.9 TTN SCN5A MYH7 ACE
5 congestive heart failure 30.9 VEGFA TTN SCN5A MYH7 ADRB1 ACE
6 pre-eclampsia 30.8 VEGFA PGF MIR210 FLT1 ACE
7 dilated cardiomyopathy 30.7 VEGFA TTN SCN5A PDCD1 MYH7 MIR146A
8 proteinuria, chronic benign 30.6 VEGFA FLT1 ACE
9 left ventricular noncompaction 30.5 TTN SCN5A MYH7 ACE
10 respiratory failure 30.4 VEGFA TTN MYH7 ACE
11 hellp syndrome 30.4 VEGFA PGF FLT1
12 mitral valve insufficiency 30.2 TTN MYH7 ACE
13 placenta accreta 30.1 VEGFA PGF FLT1
14 wolff-parkinson-white syndrome 30.1 TTN SCN5A MYH7
15 ectopic pregnancy 30.0 VEGFA PGF FLT1
16 ischemia 30.0 VEGFA MIR21 FLT1 ACE
17 atrioventricular block 30.0 TTN SCN5A MYH7 ACE
18 substance abuse 30.0 PRL DRD2 ACE
19 retinal artery occlusion 29.9 VEGFA PGF FLT1 ACE
20 placenta disease 29.9 VEGFA PGF MIR146A FLT1
21 immune deficiency disease 29.3 PDCD1 MYH7 MIR210 MIR21 MIR146A
22 limb ischemia 29.2 VEGFA PGF MIR210 MIR21 ACE
23 heart disease 28.5 VEGFA TTN SCN5A PRL PGF MYH7
24 systemic lupus erythematosus 28.3 VEGFA PRL PDCD1 MIR210 MIR21 MIR195
25 body mass index quantitative trait locus 11 28.3 VEGFA MIR21 MIR146A MIR10A GNB3 FLT1
26 myocardial infarction 28.2 VEGFA SCN5A PGF MYH7 MIR210 MIR21
27 leukemia, acute myeloid 28.2 VEGFA NRAS MIR210 MIR21 MIR195 MIR146A
28 myocarditis 10.7
29 cardiogenic shock 10.6
30 pulmonary edema 10.5
31 cardiac conduction defect 10.4
32 pulmonary embolism 10.4
33 microcystic meningioma 10.3 VEGFA FLT1
34 progressive familial heart block, type ia 10.3
35 posterior scleritis 10.3 VEGFA ACE
36 autosomal dominant distal myopathy 10.3 TTN MYH7
37 galactorrhea 10.3 PRL DRD2
38 angiokeratoma of fordyce 10.3 FLT1 ACE
39 lipodermatosclerosis 10.3 VEGFA FLT1
40 ventricular fibrillation, paroxysmal familial, 1 10.3
41 left bundle branch hemiblock 10.3
42 prolactin producing pituitary tumor 10.3 PRL DRD2
43 glomeruloid hemangioma 10.3 VEGFA PRL FLT1
44 autoimmune disease 10.3
45 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
46 pulmonary hypertension 10.3
47 acute mountain sickness 10.3 VEGFA FLT1 ACE
48 angiokeratoma circumscriptum 10.2 VEGFA FLT1
49 uterine benign neoplasm 10.2 VEGFA PRL MIR146A
50 third-degree atrioventricular block 10.2 TTN SCN5A ACE

Graphical network of the top 20 diseases related to Peripartum Cardiomyopathy:



Diseases related to Peripartum Cardiomyopathy

Symptoms & Phenotypes for Peripartum Cardiomyopathy

Human phenotypes related to Peripartum Cardiomyopathy:

58 31 (show all 45)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension 58 31 frequent (33%) Frequent (79-30%) HP:0000822
2 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
3 congestive heart failure 58 31 frequent (33%) Frequent (79-30%) HP:0001635
4 dilated cardiomyopathy 58 31 frequent (33%) Frequent (79-30%) HP:0001644
5 left ventricular hypertrophy 58 31 frequent (33%) Frequent (79-30%) HP:0001712
6 reduced ejection fraction 58 31 frequent (33%) Frequent (79-30%) HP:0012664
7 pedal edema 58 31 frequent (33%) Frequent (79-30%) HP:0010741
8 exertional dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002875
9 sinus tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0011703
10 abnormal t-wave 58 31 frequent (33%) Frequent (79-30%) HP:0005135
11 palpitations 58 31 frequent (33%) Frequent (79-30%) HP:0001962
12 elevated jugular venous pressure 58 31 frequent (33%) Frequent (79-30%) HP:0030848
13 orthopnea 58 31 frequent (33%) Frequent (79-30%) HP:0012764
14 mitral regurgitation 58 31 occasional (7.5%) Occasional (29-5%) HP:0001653
15 myocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012819
16 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
17 pulmonary arterial hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002092
18 increased serum interferon-gamma level 58 31 occasional (7.5%) Occasional (29-5%) HP:0030356
19 preeclampsia 58 31 occasional (7.5%) Occasional (29-5%) HP:0100602
20 peripheral edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0012398
21 ventricular tachycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0004756
22 thromboembolism 58 31 occasional (7.5%) Occasional (29-5%) HP:0001907
23 paroxysmal dyspnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0012763
24 heart murmur 58 31 occasional (7.5%) Occasional (29-5%) HP:0030148
25 crackles 58 31 occasional (7.5%) Occasional (29-5%) HP:0030830
26 right ventricular failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001708
27 right ventricular dilatation 58 31 occasional (7.5%) Occasional (29-5%) HP:0005133
28 abnormal atrioventricular valve morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0006705
29 left atrial enlargement 58 31 occasional (7.5%) Occasional (29-5%) HP:0031295
30 diabetes mellitus 58 31 very rare (1%) Very rare (<4-1%) HP:0000819
31 anemia 58 31 very rare (1%) Very rare (<4-1%) HP:0001903
32 obesity 58 31 very rare (1%) Very rare (<4-1%) HP:0001513
33 autoimmunity 58 31 very rare (1%) Very rare (<4-1%) HP:0002960
34 abdominal pain 58 31 very rare (1%) Very rare (<4-1%) HP:0002027
35 asthma 58 31 very rare (1%) Very rare (<4-1%) HP:0002099
36 respiratory failure 58 31 very rare (1%) Very rare (<4-1%) HP:0002878
37 left bundle branch block 58 31 very rare (1%) Very rare (<4-1%) HP:0011713
38 abnormality of thyroid physiology 58 31 very rare (1%) Very rare (<4-1%) HP:0002926
39 stroke-like episode 58 31 very rare (1%) Very rare (<4-1%) HP:0002401
40 cardiogenic shock 58 31 very rare (1%) Very rare (<4-1%) HP:0030149
41 dyspnea 58 Frequent (79-30%)
42 tachycardia 58 Frequent (79-30%)
43 abnormal cardiac atrium morphology 58 Occasional (29-5%)
44 left ventricular systolic dysfunction 58 Frequent (79-30%)
45 toxemia of pregnancy 58 Occasional (29-5%)

Clinical features from OMIM®:

614670 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Peripartum Cardiomyopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 ACE ADRB1 DRD2 FLT1 MYH7 NRAS
2 muscle MP:0005369 9.56 ADRB1 DRD2 FLT1 MYH7 PDCD1 SCN5A
3 neoplasm MP:0002006 9.17 ACE DRD2 NRAS PDCD1 PGF PRL

Drugs & Therapeutics for Peripartum Cardiomyopathy

Drugs for Peripartum Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenious acid Approved, Investigational Phase 4 7783-00-8
2
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
3 Trace Elements Phase 4
4 Nutrients Phase 4
5 Protective Agents Phase 4
6 Antioxidants Phase 4
7 Sodium Selenite Phase 4
8 Micronutrients Phase 4
9
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
10
Bromocriptine Approved, Investigational Phase 3 25614-03-3 31101
11
Heparin Approved, Investigational Phase 3 9005-49-6 772 9812414
12
Dalteparin Approved Phase 3 9005-49-6
13
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
14
Taurine Approved, Nutraceutical Phase 2, Phase 3 107-35-7 1123
15 Pharmaceutical Solutions Phase 2, Phase 3
16 Neurotransmitter Agents Phase 3
17 Dopamine Agents Phase 3
18 Hormone Antagonists Phase 3
19 Hormones Phase 3
20 Dopamine agonists Phase 3
21 Antiparkinson Agents Phase 3
22 Heparin, Low-Molecular-Weight Phase 3
23 calcium heparin Phase 3
24 Angiotensin-Converting Enzyme Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Peripartum Cardiomyopathy in Nigeria (PEACE) A Registry to Study the Demographics, Social and Clinical Characteristics, Pathophysiology and Outcomes of Peripartum Cardiomyopathy in Nigeria Completed NCT03081949 Phase 4 Oral Sodium Selenite 200 µg/day for 3 months
2 Taurine for Early Left Ventricular Recovery in Peripartum Cardiomyopathy Completed NCT03907267 Phase 2, Phase 3 Taurine Solution
3 Bromocriptine in the Treatment of Peripartum Cardiomyopathy, A Bayesian Randomized Registry Trial Recruiting NCT02590601 Phase 3 Bromocriptine
4 Effect of Bromocriptine on LV Function in Women With Peripartum Cardiomyopathy A Randomized, Controlled Clinical Trial to Evaluate the Efficacy and Safety of Bromocriptine for Improvement of Left Ventricular Function of Women With PPCM Completed NCT00998556 Phase 2 Bromocriptine
5 Pregnancy Related Cardiomyopathy Enrollment and Lessons in Web-Based Recruitment (PRiCELESS) Unknown status NCT00273637
6 Clinical A Nation-wide Registry of Peripartum Cardiomyopathy: Clinical Status in Turkey Unknown status NCT03364140
7 Immune Activation and Myocardial Recovery in Peripartum Cardiomyopathy Completed NCT01085955
8 Observational Study for Outcomes for Participants With Cardiogenic Shock and Peripartum Cardiomyopathy Not yet recruiting NCT04234659
9 Diastolic Dysfunction PPCM in Patients With Documented Left Ventricular Systolic Function Recovery Withdrawn NCT04143997

Search NIH Clinical Center for Peripartum Cardiomyopathy

Genetic Tests for Peripartum Cardiomyopathy

Anatomical Context for Peripartum Cardiomyopathy

MalaCards organs/tissues related to Peripartum Cardiomyopathy:

40
Heart, Thyroid, Brain, Placenta, Bone Marrow, Breast, Ovary

Publications for Peripartum Cardiomyopathy

Articles related to Peripartum Cardiomyopathy:

(show top 50) (show all 1331)
# Title Authors PMID Year
1
Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. 57 61
22596155 2012
2
Electrocardiographic features and their echocardiographic correlates in peripartum cardiomyopathy: results from the ESC EORP PPCM registry. 61
33453082 2021
3
Cardiomyopathy in the peripartum period due to left ventricular non-compaction and association with Ebstein's anomaly: a case report. 61
33768196 2021
4
FONTAN CIRCULATION MIGHT BE ASSOCIATED WITH PERIPARTUM CARDIOMYOPATHY: A REVIEW OF MECHANISTIC AND CLINICAL ASPECTS. 61
33726653 2021
5
Impact of COVID-19 on pregnant women with Rheumatic heart disease or Peripartum cardiomyopathy. 61
33487485 2021
6
Lipid metabolism in peripartum cardiomyopathy. 61
33349667 2021
7
Severe acute respiratory syndrome coronavirus-2- or pregnancy-related cardiomyopathy, a differential to be considered in the current pandemic: a case report. 61
33741059 2021
8
ECG and arrhythmias in peripartum cardiomyopathy. 61
33791817 2021
9
Anesthetic management of peripartum cardiomyopathy. 61
33300322 2021
10
Mechanical Circulatory Support in Women. 61
32868140 2021
11
Cerebrovascular events during pregnancy and puerperium. 61
33642057 2021
12
Postpartum pheochromocytoma-induced takotsubo syndrome. 61
33741570 2021
13
Extracorporeal life support for cardiogenic shock during pregnancy and postpartum: a single center experience. 61
33765891 2021
14
Postpartum complications increased in women with polycystic ovary syndrome. 61
32835722 2021
15
Neglected cardiovascular diseases and their significance in the Global North. 61
33506326 2021
16
Heart and brain interactions : Pathophysiology and management of cardio-psycho-neurological disorders. 61
33544152 2021
17
'The bubble heart': an unusual natural history told by multimodality imaging- a case report. 61
33598615 2021
18
Human-induced pluripotent stem cells for modelling metabolic perturbations and impaired bioenergetics underlying cardiomyopathies. 61
32365198 2021
19
Maternal Morbidity and Mortality: Are We Getting to the "Heart" of the Matter? 61
33259740 2021
20
Prognostic value of NT-proBNP for myocardial recovery in peripartum cardiomyopathy (PPCM). 61
33555408 2021
21
Peripartum Cardiomyopathy. 61
33222808 2021
22
Risk Prediction for Peripartum Cardiomyopathy in Delivering Mothers: A Validated Risk Model: PPCM Risk Prediction Model. 61
33388467 2021
23
Heart Failure and Pregnancy: Thinking Beyond Peripartum Cardiomyopathy. 61
33573757 2021
24
Peripartum Cardiomyopathy and Pregnancy-Associated Heart Failure with Preserved Ejection Fraction: More Similar Than Different. 61
33573758 2021
25
Biomarkers and Their Relation to Cardiac Function Late After Peripartum Cardiomyopathy. 61
33422687 2021
26
A Case-Control Study of Peripartum Cardiomyopathy Using the Rochester Epidemiology Project. 61
33388468 2021
27
Corrigendum to:/Retraction: Clinical presentation, management and 6-month outcomes in women with peripartum cardiomyopathy, an ESC EORP registry. 61
33200203 2021
28
Risk stratification and management of women with cardiomyopathy/heart failure planning pregnancy or presenting during/after pregnancy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum Cardiomyopathy. 61
33609068 2021
29
Challenges in the diagnosis of peripartum cardiomyopathy: a case series. 61
33738415 2021
30
Assessing the future risks of subsequent pregnancies in peripartum cardiomyopathy. 61
33433773 2021
31
Peripartum cardiomyopathy. 61
33438106 2021
32
Correction to: Selenium supplementation in patients with peripartum cardiomyopathy: a proof‑of‑concept trial. 61
33397290 2021
33
Peripartum cardiomyopathy - a cardiovascular disease in pregnancy and puerperium. The actual state of knowledge, challenges, and perspectives. 61
33084016 2021
34
Genetics of Peripartum Cardiomyopathy: Current Knowledge, Future Directions and Clinical Implications. 61
33467574 2021
35
Cardioembolic Stroke with Peripartum Cardiomyopathy: An Unusual Presentation. 61
33603310 2021
36
Increased arterial stiffness and reduced left ventricular long-axis function in patients recovered from peripartum cardiomyopathy. 61
33068494 2021
37
Cabergoline as an adjuvant to standard heart failure treatment in peripartum cardiomyopathy: A case report and review of the literature. 61
33344177 2021
38
BK virus nephropathy in a heart transplant recipient. 61
33527977 2021
39
Disparities in Cardiovascular Disease Outcomes Among Pregnant and Post-Partum Women. 61
33322915 2021
40
Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function. 61
33146391 2021
41
Dendritic cells in pregnancy and pregnancy-associated diseases. 61
33378991 2021
42
Use of extracorporeal membrane oxygenation in postpartum patients with refractory shock or respiratory failure. 61
33441897 2021
43
β1-Adrenoceptor antibodies induce PPCM via inhibition of PGC-1α related pathway. 61
33412941 2021
44
Keeping up to date: a current review of wearable cardioverter defibrillator use. 61
31687917 2020
45
Extracorporeal membrane oxygenation in pregnant and postpartum patients: a systematic review. 61
33345652 2020
46
Peripartum cardiomyopathy: An analysis of clinical profiles and outcomes from a tertiary care centre in southern India. 61
33343694 2020
47
Biventricular assist device-induced recovery from acute heart failure in peripartum cardiomyopathy on cardiac magnetic resonance imaging. 61
32847344 2020
48
When a Peripartum Cardiomyopathy Patient Hides Various and Serious Risk Factors for Recurrent and Fatal Thromboembolic Events Even Under Well-Conducted Oral Anticoagulation. 61
33532155 2020
49
Correction: Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy. 61
33154145 2020
50
Peripartum cardiomyopathy: An uncommon cause of ischemic stroke. 61
33181805 2020

Variations for Peripartum Cardiomyopathy

Expression for Peripartum Cardiomyopathy

Search GEO for disease gene expression data for Peripartum Cardiomyopathy.

Pathways for Peripartum Cardiomyopathy

Pathways related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 VEGFA SCN5A NRAS GNB3 DRD2 ADRB1
2
Show member pathways
12.68 VEGFA PRL PGF NRAS GNB3 FLT1
3
Show member pathways
12.28 VEGFA PGF NRAS GNB3 FLT1 DRD2
4
Show member pathways
12.18 VEGFA PGF NRAS FLT1
5 12.07 VEGFA NRAS MIR21 MIR10A
6
Show member pathways
11.97 TTN MYH7 ADRB1 ACE
7 11.83 VEGFA SCN5A MIR210 GNB3
8 11.66 VEGFA NRAS MIR210 MIR21 MIR195 MIR146A
9
Show member pathways
11.63 VEGFA PGF FLT1
10 11.6 NRAS DRD2 ADRB1
11 11.07 VEGFA NRAS FLT1
12
Show member pathways
10.34 VEGFA PGF FLT1

GO Terms for Peripartum Cardiomyopathy

Cellular components related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 VEGFA PRL PGF MIR210 MIR21 MIR146A

Biological processes related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.21 VEGFA PRL PGF NRAS GNB3 DRD2
2 gene silencing by miRNA GO:0035195 10 MIR210 MIR21 MIR195 MIR146A MIR10A
3 positive regulation of cell proliferation GO:0008284 9.99 VEGFA PRL PGF MIR21 FLT1
4 miRNA mediated inhibition of translation GO:0035278 9.8 MIR210 MIR21 MIR146A
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.77 VEGFA MIR21 FLT1
6 positive regulation of endothelial cell proliferation GO:0001938 9.74 VEGFA PGF NRAS
7 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.72 VEGFA PGF FLT1
8 negative regulation of angiogenesis GO:0016525 9.67 PRL MIR21 MIR146A MIR10A
9 cardiac muscle contraction GO:0060048 9.65 TTN SCN5A MYH7
10 positive regulation of cell migration GO:0030335 9.65 VEGFA MIR210 MIR21 FLT1 CD274
11 striated muscle contraction GO:0006941 9.63 TTN MYH7
12 negative regulation of endothelial cell proliferation GO:0001937 9.63 PRL MIR21 MIR146A
13 induction of positive chemotaxis GO:0050930 9.62 VEGFA PGF
14 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.61 VEGFA MIR146A MIR10A
15 tube formation GO:0035148 9.58 VEGFA MIR210
16 cardiac muscle hypertrophy GO:0003300 9.58 TTN MIR195
17 cardiac muscle fiber development GO:0048739 9.56 VEGFA TTN
18 hyaloid vascular plexus regression GO:1990384 9.54 FLT1 DRD2
19 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.52 MIR210 MIR21
20 positive regulation of mast cell chemotaxis GO:0060754 9.51 VEGFA PGF
21 regulation of heart rate GO:0002027 9.5 SCN5A MYH7 DRD2
22 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.49 VEGFA ACE
23 regulation of locomotion involved in locomotory behavior GO:0090325 9.4 GNB3 DRD2
24 positive regulation of angiogenesis GO:0045766 9.35 VEGFA PGF MIR210 MIR21 FLT1
25 vascular endothelial growth factor signaling pathway GO:0038084 9.33 VEGFA PGF FLT1
26 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 8.92 VEGFA MIR21 MIR146A MIR10A

Molecular functions related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.02 MIR210 MIR21 MIR195 MIR146A MIR10A
2 vascular endothelial growth factor receptor binding GO:0005172 8.96 VEGFA PGF

Sources for Peripartum Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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