PPCM
MCID: PRP009
MIFTS: 50

Peripartum Cardiomyopathy (PPCM)

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Peripartum Cardiomyopathy

MalaCards integrated aliases for Peripartum Cardiomyopathy:

Name: Peripartum Cardiomyopathy 57 12 76 53 59 15 73
Postpartum Cardiomyopathy 53 59 73
Peripartum Cardiomyopathy, Susceptibility to 57
Antepartum Peripartum Cardiomyopathy 12
Postpartum Peripartum Cardiomyopathy 12
Cardiomyopathy, Peripartum 40
Ppcm, Susceptibility to 57
Meadows' Syndrome 53
Ppcm 57

Characteristics:

Orphanet epidemiological data:

59
peripartum cardiomyopathy
Age of onset: Adult;

Classifications:



External Ids:

OMIM 57 614670
Disease Ontology 12 DOID:9997
ICD10 33 O90.3
ICD9CM 35 674.5
SNOMED-CT 68 16253001
Orphanet 59 ORPHA563
UMLS via Orphanet 74 C0877208 C0269972
ICD10 via Orphanet 34 O90.3

Summaries for Peripartum Cardiomyopathy

OMIM : 57 Peripartum cardiomyopathy (PPCM) is characterized by systolic heart failure presenting in the last month of pregnancy or the first 5 months postpartum. PPCM affects 1 in 300 to 1 in 3,000 pregnancies, with geographic hot spots of high incidence, such as Nigeria and Haiti. Although approximately half of affected women recover cardiac function postpartum, many patients progress to chronic heart failure, cardiac transplantation, or death. Data have suggested that antiangiogenic prolactin (176760) fragments may have an important role in causing the disease in some patients. Risk factors for PPCM also include preeclampsia (see 189800) and multiple gestation, suggesting a potential mechanistic overlap with these processes (summary by Patten et al., 2012). (614670)

MalaCards based summary : Peripartum Cardiomyopathy, also known as postpartum cardiomyopathy, is related to hyperprolactinemia and dilated cardiomyopathy. An important gene associated with Peripartum Cardiomyopathy is PRL (Prolactin), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. The drugs Selenium and Selenious acid have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and placenta, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 563Disease definitionPeripartum cardiomyopathy (PPCM) is an idiopathic, potentially fatal form of dilated cardiomyopathy that develops during the final month of pregnancy or within five months after delivery.Visit the Orphanet disease page for more resources.

Wikipedia : 76 Peripartum cardiomyopathy (PPCM) is a form of dilated cardiomyopathy that is defined as a deterioration... more...

Related Diseases for Peripartum Cardiomyopathy

Diseases related to Peripartum Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 hyperprolactinemia 30.3 DRD2 PRL
2 dilated cardiomyopathy 30.1 ACE MYH7 PDCD1 TTN
3 cocaine abuse 29.8 DRD2 PRL
4 hypertrophic cardiomyopathy 29.5 ACE MYH7 TTN
5 systemic lupus erythematosus 29.5 ACE CD274 PDCD1 PRL
6 pre-eclampsia 10.3
7 left ventricular noncompaction 10.3
8 eclampsia 10.2
9 cardiac arrest 10.2
10 myocarditis 10.2
11 pulmonary embolism 10.2
12 cardiogenic shock 10.2
13 galactorrhea 10.1 DRD2 PRL
14 schizophreniform disorder 10.1 DRD2 PRL
15 prolactin producing pituitary tumor 10.1 DRD2 PRL
16 social phobia 10.1 DRD2 PRL
17 functioning pituitary adenoma 10.1 DRD2 PRL
18 sexual disorder 10.1 ACE PRL
19 cardiomyopathy, dilated, 1b 10.1
20 muscular dystrophy, congenital, 1b 10.1
21 myocardial infarction 10.1
22 pulmonary edema 10.1
23 heart disease 10.1
24 multiple endocrine neoplasia 10.1
25 migraine without aura 10.1 DRD2 PRL
26 personality disorder 10.1 DRD2 PRL
27 acute mountain sickness 10.1 ACE FLT1
28 pituitary adenoma, prolactin-secreting 10.1 DRD2 PRL
29 substance abuse 10.1 DRD2 PRL
30 myopathy, spheroid body 10.1 MYH7 TTN
31 retinal vascular disease 10.1 ACE FLT1
32 interstitial nephritis 10.1 ACE PDCD1
33 familial isolated dilated cardiomyopathy 10.1 MYH7 TTN
34 schizoaffective disorder 10.1 DRD2 PRL
35 human immunodeficiency virus type 1 10.0
36 genital herpes 10.0
37 miyoshi muscular dystrophy 10.0 MYH7 TTN
38 rigid spine muscular dystrophy 1 10.0 MYH7 TTN
39 alcohol abuse 10.0 DRD2 PRL
40 cardiomyopathy, dilated, 1e 10.0 MYH7 TTN
41 multiple endocrine neoplasia, type i 10.0
42 ventricular fibrillation, paroxysmal familial, 1 10.0
43 acute myocardial infarction 10.0
44 ventricular septal defect 10.0
45 lupus erythematosus 10.0
46 microvascular complications of diabetes 5 10.0 ACE FLT1
47 cardiomyopathy, familial hypertrophic, 1 10.0 MYH7 TTN
48 migraine with aura 10.0 ACE DRD2
49 arteries, anomalies of 10.0 ACE FLT1
50 lymphoepithelioma-like carcinoma 10.0 CD274 PDCD1

Graphical network of the top 20 diseases related to Peripartum Cardiomyopathy:



Diseases related to Peripartum Cardiomyopathy

Symptoms & Phenotypes for Peripartum Cardiomyopathy

Clinical features from OMIM:

614670

GenomeRNAi Phenotypes related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.73 DRD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.73 MYH7
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.73 MYH7
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.73 MYH7
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.73 DRD2 FLT1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.73 DRD2 FLT1 MYH7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.73 FLT1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.73 FLT1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.73 DRD2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.55 CD274
11 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.55 CD274
12 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.55 CD274
13 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.55 MYH7
14 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.55 MYH7
15 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.55 MYH7
16 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.55 MYH7
17 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.55 CD274
18 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.55 CD274 MYH7 PDCD1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.55 CD274
20 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.55 PDCD1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.55 PDCD1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.55 PDCD1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.55 MYH7
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 CD274

MGI Mouse Phenotypes related to Peripartum Cardiomyopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ACE CD274 DRD2 FLT1 PRL TTN
2 cardiovascular system MP:0005385 9.8 ACE DRD2 FLT1 MYH7 PDCD1 TTN
3 homeostasis/metabolism MP:0005376 9.8 ACE CD274 DRD2 FLT1 PDCD1 PRL
4 immune system MP:0005387 9.7 ACE CD274 DRD2 FLT1 PDCD1 PRL
5 muscle MP:0005369 9.35 DRD2 FLT1 MYH7 PDCD1 TTN
6 neoplasm MP:0002006 8.92 ACE DRD2 PDCD1 PRL

Drugs & Therapeutics for Peripartum Cardiomyopathy

Drugs for Peripartum Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
2
Selenious acid Approved, Investigational Phase 4 7783-00-8
3 Antioxidants Phase 4
4 Trace Elements Phase 4
5 Protective Agents Phase 4
6 Sodium Selenite Phase 4
7 Micronutrients Phase 4
8
Bromocriptine Approved, Investigational Phase 3,Phase 2 25614-03-3 31101
9
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
10
Dalteparin Approved Phase 3 9005-49-6
11
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
12 Neurotransmitter Agents Phase 3,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
14 Hormones Phase 3,Phase 2
15 Hormone Antagonists Phase 3,Phase 2
16 Antiparkinson Agents Phase 3,Phase 2
17 Dopamine Agents Phase 3,Phase 2
18 Dopamine agonists Phase 3,Phase 2
19 calcium heparin Phase 3
20 Heparin, Low-Molecular-Weight Phase 3
21 Angiotensin-Converting Enzyme Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Peripartum Cardiomyopathy in Nigeria Registry Recruiting NCT03081949 Phase 4 Oral Sodium Selenite 200 µg/day for 3 months
2 Bromocriptine in the Treatment of Peripartum Cardiomyopathy Recruiting NCT02590601 Phase 3 Bromocriptine
3 Effect of Bromocriptine on Left Ventricular Function in Women With Peripartum Cardiomyopathy Completed NCT00998556 Phase 2 Bromocriptine
4 Registry and Survey of Women With Pregnancy Related Cardiomyopathy Unknown status NCT00273637
5 Investigation in Pregnancy Associate Cardiomyopathy Completed NCT01085955
6 The Study of Cardiovascular Outcomes in Women With Preeclampsia Using Echocardiography: The SCOPE Study Completed NCT02357667
7 A Registry of Peripartum Cardiomyopathy in Turkey Recruiting NCT03364140
8 Pregnancy and Dilated Cardiomyopathy Recruiting NCT03235063

Search NIH Clinical Center for Peripartum Cardiomyopathy

Genetic Tests for Peripartum Cardiomyopathy

Anatomical Context for Peripartum Cardiomyopathy

MalaCards organs/tissues related to Peripartum Cardiomyopathy:

41
Heart, Testes, Placenta, Brain, Liver, Pituitary, Myeloid

Publications for Peripartum Cardiomyopathy

Articles related to Peripartum Cardiomyopathy:

(show top 50) (show all 735)
# Title Authors Year
1
Psychosocial Adjustment and Quality of Life in Patients With Peripartum Cardiomyopathy. ( 30273257 )
2019
2
Peripartum Cardiomyopathy: Progress in Understanding the Etiology, Management, and Prognosis. ( 30449378 )
2019
3
A Case Report of Recurrent Severe Peripartum Cardiomyopathy Complicated by Factor V Leiden and Multiple Endocrine Neoplasia Type 1: A Management Conundrum. ( 29652683 )
2018
4
Bromocriptine for the Treatment of Peripartum Cardiomyopathy. ( 29892477 )
2018
5
Cardiogenic shock complicating peripartum cardiomyopathy: Importance of early left ventricular unloading and bromocriptine therapy. ( 29792513 )
2018
6
The rationale and design of the national peripartum cardiomyopathy registries in Turkey: The ARTEMIS-I and ARTEMIS-II studies. ( 29339690 )
2018
7
Maternal and fetal prognosis of subsequent pregnancy in black African women with peripartum cardiomyopathy. ( 29914408 )
2018
8
Peripartum Cardiomyopathy and Preeclampsia: Overlapping Diseases of Pregnancy. ( 29971645 )
2018
9
Psychological adaptation after peripartum cardiomyopathy: A qualitative study. ( 29655005 )
2018
10
Etiologies, Predictors, and Economic Impact of 30-Day Readmissions Among Patients With Peripartum Cardiomyopathy. ( 29703438 )
2018
11
June 2018 at a glance: peripartum cardiomyopathy and pathophysiology, prognosis, and device therapy of heart failure. ( 29870145 )
2018
12
A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. ( 29761889 )
2018
13
Anomalous Left Coronary Artery From the Pulmonary Artery: Masquerading as Peripartum Cardiomyopathy. ( 29530774 )
2018
14
Peripartum cardiomyopathy: A systematic review of the literature. ( 29749620 )
2018
15
Predictors of early and delayed recovery in peripartum cardiomyopathy: A prospective study of 52 patients. ( 29945487 )
2018
16
Clinical Profile and Outcome of Peripartum Cardiomyopathy - A Study in a Tertiary Cardiac Hospital of Bangladesh. ( 29769494 )
2018
17
Arrhythmic manifestation of peripartum cardiomyopathy-Case report. ( 29667277 )
2018
18
Initial Right Ventricular Dysfunction Severity Identifies Severe Peripartum Cardiomyopathy Phenotype With Worse Early and Overall Outcomes: A 24-Year Cohort Study. ( 29686029 )
2018
19
Successful management of fatal peripartum cardiomyopathy in a young pregnant woman: A case report. ( 29642207 )
2018
20
Peripartum cardiomyopathy: Status 2018. ( 29451958 )
2018
21
Anticoagulation Therapy in Specific Cardiomyopathies: Isolated Left Ventricular Noncompaction and Peripartum Cardiomyopathy. ( 29911432 )
2018
22
New Insights in Peripartum Cardiomyopathy. ( 29747731 )
2018
23
When baby 'pushed the button': an exceptional peripartum cardiomyopathy-like syndrome. ( 29931056 )
2018
24
Peripartum Serial Echocardiographic Findings in a Patient with Life-threatening Peripartum Cardiomyopathy. ( 29877258 )
2018
25
Subsequent Pregnancy Outcomes in Patients With Peripartum Cardiomyopathy. ( 29324614 )
2018
26
Peripartum cardiomyopathy. ( 29767811 )
2018
27
Circulating T-Cell Subsets, Monocytes, and Natural Killer Cells in Peripartum Cardiomyopathy: Results From the Multicenter IPAC Study. ( 29079307 )
2018
28
Symptomatic recovery and pharmacological management in a clinical cohort with peripartum cardiomyopathy. ( 28462600 )
2018
29
Peripartum cardiomyopathy - from pathogenesis to treatment. ( 28489560 )
2018
30
Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study. ( 29455790 )
2018
31
Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience. ( 29466490 )
2018
32
Re: Subsequent reproductive outcome among women with peripartum cardiomyopathy: a nationwide study. ( 29468806 )
2018
33
Authors' reply re: Subsequent reproductive outcome among women with peripartum cardiomyopathy: a nationwide study. ( 29479809 )
2018
34
A Population-based Study of Peripartum Cardiomyopathy in Southern Israel: Are Bedouin Women a New High-risk Group? ( 29514040 )
2018
35
Venous thromboembolism associated splenic and renal infarction in a patient with peripartum cardiomyopathy. ( 29546684 )
2018
36
Placenta accreta complicated with peripartum cardiomyopathy. ( 29574429 )
2018
37
Long-term prognosis, subsequent pregnancy, contraception and overall management of peripartum cardiomyopathy: practical guidance paper from the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum Cardiomyopathy. ( 29578284 )
2018
38
Peripartum cardiomyopathy: approach to management. ( 29601327 )
2018
39
Incidence, Risk Factors, and Clinical Characteristics of Peripartum Cardiomyopathy in South Korea. ( 29626099 )
2018
40
Devil in Disguise: Hints and Pitfalls in Diagnosis of Peripartum Cardiomyopathy. ( 29626100 )
2018
41
Severe Course of Peripartum Cardiomyopathy and Subsequent Recovery in a Patient with a Novel TTN Gene-Truncating Mutation. ( 29997384 )
2018
42
Reply to 'Bromocriptine for the treatment of peripartum cardiomyopathy: comparison of outcome with a nationwide Danish cohort'. ( 30016421 )
2018
43
Bromocriptine for the treatment of peripartum cardiomyopathy: comparison of outcome with a Danish cohort. ( 30016425 )
2018
44
Readmissions Among Patients With Peripartum Cardiomyopathy. ( 30049461 )
2018
45
Peripartum Cardiomyopathy: an Update. ( 30051292 )
2018
46
Peripartum cardiomyopathy with advanced heart failure, complicated by thrombosis and pulmonary embolism with right lower lobe infarction: a therapeutic and diagnostic challenge. ( 30057381 )
2018
47
Peripartum women with dyspnea in the emergency department: Is it peripartum cardiomyopathy? ( 30075517 )
2018
48
Fathers' experiences of care when their partners suffer from peripartum cardiomyopathy: a qualitative interview study. ( 30103706 )
2018
49
Peripartum cardiomyopathy-diagnosis, management, and long term implications. ( 30111492 )
2018
50
Bromocriptine treatment in patients with peripartum cardiomyopathy and right ventricular dysfunction. ( 30121697 )
2018

Variations for Peripartum Cardiomyopathy

Expression for Peripartum Cardiomyopathy

Search GEO for disease gene expression data for Peripartum Cardiomyopathy.

Pathways for Peripartum Cardiomyopathy

Pathways related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.04 ACE MYH7 TTN
2 10.72 CD274 PDCD1

GO Terms for Peripartum Cardiomyopathy

Cellular components related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 8.96 MYH7 TTN
2 external side of plasma membrane GO:0009897 8.8 ACE CD274 PDCD1

Biological processes related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell costimulation GO:0031295 9.37 CD274 PDCD1
2 cardiac muscle contraction GO:0060048 9.32 MYH7 TTN
3 muscle filament sliding GO:0030049 9.26 MYH7 TTN
4 regulation of heart rate GO:0002027 9.16 DRD2 MYH7
5 arachidonic acid secretion GO:0050482 8.96 ACE DRD2
6 striated muscle contraction GO:0006941 8.62 MYH7 TTN

Molecular functions related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 8.62 ACE DRD2

Sources for Peripartum Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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