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MCID: PRP080
MIFTS: 53

Peripheral Artery Disease

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Peripheral Artery Disease

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MalaCards integrated aliases for Peripheral Artery Disease:

Name: Peripheral Artery Disease 12 15
Peripheral Arterial Diseases 73

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050830
UMLS 73 C1704436
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Summaries for Peripheral Artery Disease

About this section
Disease Ontology : 12 An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs.

MalaCards based summary : Peripheral Artery Disease, also known as peripheral arterial diseases, is related to critical limb ischemia and peripheral vascular disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Peripheral Artery Disease is CDKN2B-AS1 (CDKN2B Antisense RNA 1
SNP rs2383207 on ANRIL was most significantly associated with lower ABI.
Dysfunction Pattern: Mutation), and among its related pathways/superpathways are Innate Immune System and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and bone, and related phenotypes are Decreased free cholesterol and cardiovascular system

Wikipedia : 76 Peripheral artery disease (PAD) is a narrowing of the arteries other than those that supply the heart or... more...

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Related Diseases for Peripheral Artery Disease

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Diseases related to Peripheral Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 critical limb ischemia 32.7 IL6 VEGFA
2 peripheral vascular disease 31.0 ACE APOB CRP IL6 SELP VCAM1
3 cardiogenic shock 30.4 CRP IL6
4 intermittent claudication 30.4 ACE CRP IL6 SELP VEGFA
5 limb ischemia 30.3 ACE IL6 NOS3 VEGFA
6 ischemia 30.2 ACE NOS3 SELP VEGFA
7 end stage renal failure 29.9 ACE CRP CST3 IL6
8 temporal arteritis 29.9 CCL2 CRP IL6
9 aortic valve disease 2 29.9 ACE CRP TNFRSF11B
10 carotid artery disease 29.7 ACE APOB CCL2 CRP
11 venous insufficiency 29.7 CRP SELP VCAM1
12 periodontal disease 29.7 CRP IL6 TNFRSF11B
13 peritonitis 29.7 CCL2 CRP IL6
14 pneumonia 29.6 CCL2 CRP IL6
15 arteriosclerosis obliterans 29.6 IL6 SELP VCAM1
16 systolic heart failure 29.6 ACE CRP CST3 IL6
17 pulmonary disease, chronic obstructive 29.4 CCL2 CRP IL6
18 coronary heart disease 1 29.3 ACE APOB CRP PCSK9
19 kidney disease 29.0 ACE CCL2 CRP CST3 TNFRSF11B
20 heart disease 29.0 ACE APOB CRP CST3 IL6 NOS3
21 microvascular complications of diabetes 1 28.9 CCL2 VCAM1 VEGFA
22 cerebrovascular disease 28.7 ACE APOB CRP IL6 SELP VCAM1
23 atherosclerosis susceptibility 28.6 APOB CCL2 CDKN2B-AS1 CRP IL6 NOS3
24 microvascular complications of diabetes 5 28.6 ACE NOS3 VCAM1 VEGFA
25 carotid stenosis 28.6 ACE CDKN2B-AS1 CRP SELP TNFRSF11B
26 hypercholesterolemia, familial 28.4 APOB CRP NOS3 PCSK9
27 chronic kidney failure 28.4 ACE CRP CST3 IL6 TNFRSF11B VCAM1
28 periodontitis 28.4 CCL2 CDKN2B-AS1 CRP IL6 TNFRSF11B
29 diabetes mellitus 28.3 ACE APOB CDKN2B-AS1 CRP IL6 NOS3
30 systemic lupus erythematosus 28.2 CCL2 CRP IL6 NLRP1 VCAM1
31 aortic aneurysm, familial abdominal, 1 28.2 CCL2 CDKN2B-AS1 CRP CST3 IL6 TNFRSF11B
32 stroke, ischemic 27.5 ACE APOB CDKN2B-AS1 CRP NOS3 P2RY12
33 arteriosclerosis 27.4 ACE APOB CCL2 CRP IL6 SELP
34 arteries, anomalies of 27.4 ACE APOB CCL2 CRP IL6 NOS3
35 diabetes mellitus, noninsulin-dependent 26.0 ACE APOB CCL2 CDKN2B-AS1 CRP IL6
36 myocardial infarction 25.5 ACE APOB CCL2 CDKN2B-AS1 CRP CST3
37 vascular disease 24.9 ACE APOB CCL2 CRP CST3 IL6
38 coronary artery anomaly 24.4 ACE APOB CCL2 CDKN2B-AS1 CRP CST3
39 cold agglutinin disease 10.8 CRP IL6
40 intracranial arteriosclerosis 10.8
41 cryopyrin-associated periodic syndrome 10.7 CRP IL6
42 acute cholangitis 10.7 CRP IL6
43 neutrophilia, hereditary 10.7 CRP IL6
44 uremic pruritus 10.6 CRP IL6
45 prediabetes syndrome 10.6 APOB CRP IL6
46 castleman disease 10.6 CRP IL6
47 generalized atherosclerosis 10.6 ACE CRP SELP
48 osteoporotic fracture 10.6 IL6 TNFRSF11B
49 lipid metabolism disorder 10.6 ACE APOB CRP
50 platelet membrane fluidity 10.6 NOS3 SELP

Graphical network of the top 20 diseases related to Peripheral Artery Disease:



Diseases related to Peripheral Artery Disease
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Symptoms & Phenotypes for Peripheral Artery Disease

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UMLS symptoms related to Peripheral Artery Disease:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.8 APOB PCSK9 SELP

MGI Mouse Phenotypes related to Peripheral Artery Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 IL6 VEGFA NOS3 ACE SELP APOB
2 homeostasis/metabolism MP:0005376 9.93 IL6 VEGFA NLRP1 NOS3 P2RY12 PCSK9
3 hematopoietic system MP:0005397 9.91 IL6 VEGFA NLRP1 NOS3 P2RY12 ACE
4 immune system MP:0005387 9.7 NLRP1 NOS3 ACE SELP APOB TNFRSF11B
5 liver/biliary system MP:0005370 9.17 IL6 VEGFA NOS3 PCSK9 ACE SELP
Sources

Drugs & Therapeutics for Peripheral Artery Disease

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Drugs for Peripheral Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 432)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
2
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 120202-66-6, 113665-84-2 60606
3
Angiotensin II Approved, Investigational Phase 4,Phase 2,Early Phase 1,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
4
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
5
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
6
Metformin Approved Phase 4,Phase 3,Not Applicable 657-24-9 14219 4091
7
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 79902-63-9 54454
8
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
9
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73963-72-1 2754
10
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
11
Clonidine Approved Phase 4,Early Phase 1 4205-90-7 2803
12
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
13
Morphine Approved, Investigational Phase 4 57-27-2 5288826
14
Amlodipine Approved Phase 4,Early Phase 1 88150-42-9 2162
15
Losartan Approved Phase 4,Early Phase 1 114798-26-4 3961
16
Methyltestosterone Approved Phase 4 58-18-4 6010
17
Testosterone Approved, Investigational Phase 4 58-22-0 6013
18
Testosterone enanthate Approved Phase 4 315-37-7 9416
19
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
20
Nitric Oxide Approved Phase 4,Phase 2,Not Applicable 10102-43-9 145068 160954
21
Menthol Approved Phase 4,Phase 2,Phase 3,Not Applicable 2216-51-5 16666
22
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2 745-65-3 149351 5280723
23
Warfarin Approved Phase 4,Phase 3 81-81-2 6691 54678486
24
Pravastatin Approved Phase 4,Phase 3,Phase 1 81093-37-0 54687
25
Allopurinol Approved Phase 4 315-30-0 2094
26
Ramipril Approved Phase 4 87333-19-5 5362129
27
Ezetimibe Approved Phase 4,Phase 3,Not Applicable 163222-33-1 150311
28
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 55142-85-3 5472
29
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
30
Dalteparin Approved Phase 4 9005-49-6
31 Defibrotide Approved, Investigational Phase 4 83712-60-1
32
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 9005-49-6 772 46507594
33
Iloprost Approved, Investigational Phase 4,Phase 2 78919-13-8 6443959
34
Pentoxifylline Approved, Investigational Phase 4,Phase 3 6493-05-6 4740
35
Eplerenone Approved Phase 4 107724-20-9 150310 443872
36
Spironolactone Approved Phase 4,Early Phase 1 1952-01-7, 52-01-7 5833
37
Telmisartan Approved, Investigational Phase 4,Not Applicable 144701-48-4 65999
38
Thrombin Approved, Investigational Phase 4,Phase 3,Not Applicable
39
Vorapaxar Approved Phase 4,Phase 3 618385-01-6
40
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Not Applicable 274693-27-5 9871419
41
Apixaban Approved Phase 4 503612-47-3 10182969
42 Edoxaban Approved Phase 4,Phase 2 480449-70-5
43
Rivaroxaban Approved Phase 4,Phase 3,Phase 2 366789-02-8
44
Hydrochlorothiazide Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 58-93-5 3639
45
Zinc Approved, Investigational Phase 4,Phase 1,Not Applicable 7440-66-6 23994
46
Nicorandil Approved, Investigational Phase 4 65141-46-0 47528
47
Adenosine Approved, Investigational Phase 4,Phase 2,Not Applicable 58-61-7 60961
48
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
49
Insulin Glargine Approved Phase 4 160337-95-1
50
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5280427 5282411

Interventional clinical trials:

(show top 50) (show all 1133)
# Name Status NCT ID Phase Drugs
1 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
2 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
3 Effect of olmesaRtan on Walking distancE and quaLIty of lifE in Peripheral Artery Disease Patients With Hypertension Treated For Intermittent Claudication (RELIEF) Unknown status NCT02373462 Phase 4 Olmesartan;other anti-hypertensive drug
4 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Unknown status NCT01901224 Phase 4 Metformin 1000 mg;Placebo
5 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
6 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
7 Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease Unknown status NCT00144937 Phase 4 Stepwise therapy for dyslipidemia, hypertension and diabetes
8 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
9 Paclitaxel-eluting Balloon Angioplasty With Provisional Use of Nitinol Stent Versus Systematic Implantation of Paclitaxel-eluting Stent for the Treatment of Femoropopliteal de Novo Lesions Unknown status NCT01969630 Phase 4
10 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
11 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
12 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
13 Platelets Induced Vasodilation, in Vitro and in Vivo Study Unknown status NCT00152646 Phase 4 placebo, aspirine, clopidogrel
14 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
15 Comparison of Stenting Versus Best Medical Therapy for Treatment of Ostial Renal Artery Stenosis: a Trial in Patients With Advanced Atherosclerosis Unknown status NCT00711984 Phase 4
16 Prevena Vascular Groin Wound Study Unknown status NCT02581904 Phase 4
17 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4 levobupivacaine, clonidine
18 Hypertension Control Based on Home Blood Pressure Unknown status NCT00198562 Phase 4 Amlodipine, Losartan
19 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
20 Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease Completed NCT01041729 Phase 4 Atorvastatin;Standard Medical Treatment
21 Allopurinol as a Possible Oxygen Sparing Agent During Exercise in Peripheral Arterial Disease Completed NCT01147705 Phase 4 Allopurinol;Placebo
22 Angiotensin Converting Enzyme (ACE) Inhibition and Peripheral Arterial Disease Completed NCT00681226 Phase 4 Ramipril or matching placebo
23 Intermittent Mechanical Compression For Peripheral Arterial Disease Completed NCT00855673 Phase 4 Control
24 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed NCT00687076 Phase 4 Ezetimibe;Niaspan;Statin therapy;Aspirin;Clopidogrel;Placebo Niaspan;Placebo Ezetimibe
25 The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease Completed NCT00168467 Phase 4 Ramipril
26 The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) Completed NCT00189618 Phase 4 Aspirin;Clopidogrel
27 Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease Completed NCT01983449 Phase 4 Dexamethasone Sodium Phosphate Injection, USP
28 The Jetstream G3™ Calcium Study Completed NCT01273623 Phase 4
29 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
30 Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease Completed NCT01026389 Phase 4 Dotarem;Gadovist
31 Evaluation of Cilostazol in Combination With L-Carnitine Completed NCT00822172 Phase 4 cilostazol
32 Angioplasty in Peripheral Arterial Disease and Endothelial Function Completed NCT00660634 Phase 4
33 The Jetstream (JET) Post-market Registry Completed NCT01436435 Phase 4
34 Arterial Inflow and Muscle Ischemia During Calf Stimulation With the Veinoplus Device Completed NCT01592812 Phase 4
35 Paclitaxel-coated Balloons in Femoral Indication to Defeat Restenosis Completed NCT01083030 Phase 4
36 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
37 Drug Eluting Balloon in peripherAl inTErvention SFA Completed NCT01556542 Phase 4
38 DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in Patients With Abdominal or Lower Limb Arterial Diseases Completed NCT00955617 Phase 4
39 A Study to Collect Intravascular Ultrasound Images Before and After Treatment With the Jetstream System Completed NCT00911417 Phase 4
40 Protective Effect of EPA on Cardiovascular Events Completed NCT00231738 Phase 4 Eicosapentaenoic acid ethyl ester(EPADEL Capsule 300 TM)
41 Effect of Cilostazol Endothelial Progenitor Cells and Collateral Formation in Peripheral Occlusive Artery Disease (PAOD) Completed NCT01952756 Phase 4 Cilostazol;Dummy Placebo
42 BeSmooth Study, Investigating the BeSmooth Peripheral Stent System for the Treatment of Iliac Lesions Completed NCT02690051 Phase 4
43 EverFlex™ Self-expanding Peripheral Stent With Entrust™ Delivery System Clinical Study Completed NCT02066740 Phase 4
44 DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions Completed NCT01412463 Phase 4
45 Efficacity Study With the Protégé EverFlex Stent in Popliteal Lesions Completed NCT01412450 Phase 4
46 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
47 Effect of Plavix on NO (Nitrogen Monoxide) Production of the Endothelial Function Completed NCT00648453 Phase 4 Clopidogrel (Plavix)
48 Comparing Angioplasty and DES in the Treatment of Subjects With Ischemic Infrapopliteal Arterial Disease Completed NCT00640770 Phase 4
49 Optimization of Treatment in Patients With Severe Peripheral Ischemia (Fontaine Stage IIb) Completed NCT01718288 Phase 4 iloprost;Standard Treatment (aspirin.....),
50 Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia Completed NCT02369809 Phase 4 Neovasculgen®

Search NIH Clinical Center for Peripheral Artery Disease

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Genetic Tests for Peripheral Artery Disease

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Anatomical Context for Peripheral Artery Disease

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MalaCards organs/tissues related to Peripheral Artery Disease:

41
Heart, Endothelial, Bone, Bone Marrow, Skin, Kidney, Testes
Sources

Publications for Peripheral Artery Disease

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Articles related to Peripheral Artery Disease:

(show top 50) (show all 633)
# Title Authors Year
1
Time trends in peripheral artery disease incidence, prevalence and secondary preventive therapy: a cohort study in The Health Improvement Network in the UK. ( 29358428 )
2018
2
Peripheral Artery Disease and Continuous Flow Left Ventricle Assist Device: An Engaging Complement Analysis May Help to Guide Treatment. ( 29436002 )
2018
3
Microfibrillar-associated protein 4 variation in symptomatic peripheral artery disease. ( 29884190 )
2018
4
Effect of cilostazol on platelet reactivity among patients with peripheral artery disease on clopidogrel therapy. ( 29408797 )
2018
5
Statin prescription rates and their facility-level variation in patients with peripheral artery disease and ischemic cerebrovascular disease: Insights from the Department of Veterans Affairs. ( 29600737 )
2018
6
Beet the Best? Dietary Inorganic Nitrate to Augment Exercise Training in Lower Extremity Peripheral Artery Disease with Intermittent Claudication. ( 29976553 )
2018
7
Lipid-lowering treatment in peripheral artery disease. ( 29413998 )
2018
8
Under-utilization of statin medications in patients with peripheral artery disease or cerebrovascular disease. ( 29600738 )
2018
9
Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome. ( 29910052 )
2018
10
High serum leptin level is associated with peripheral artery disease in adult peritoneal dialysis patients. ( 29875588 )
2018
11
Review of biologic and behavioral risk factors linking depression and peripheral artery disease. ( 29801423 )
2018
12
Improvement of bilateral lower-limb muscle oxygenation by low-density lipoprotein apheresis in a patient with peripheral artery disease undergoing hemodialysis. ( 29422296 )
2018
13
Osteoprotegerin concentration is associated with the presence and severity of peripheral arterial disease in type 2 diabetes mellitus. ( 29313442 )
2018
14
Peripheral artery disease: How do genes and pharmacology interplay? ( 29894588 )
2018
15
Non-ST Elevation Myocardial Infarction and Severe Peripheral Artery Disease in a 20-Year-Old with Perinatally Acquired Human Immunodeficiency Virus Infection. ( 29808134 )
2018
16
Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis. ( 29980169 )
2018
17
PCSK9 inhibition for LDL lowering and beyond - implications for patients with peripheral artery disease. ( 29412075 )
2018
18
Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients. ( 29449336 )
2018
19
Translation and Validation of the Brazilian-Portuguese Short Version of Vascular Quality of Life Questionnaire in Peripheral Artery Disease Patients with Intermittent Claudication Symptoms. ( 29772330 )
2018
20
Simultaneous Hybrid Operation Common Femoral Endarterectomy and Endovascular Treatment in Multilevel Peripheral Arterial Disease with Critical Limb Ischemia. ( 29915480 )
2018
21
Critical Appraisal of the Quality of Evidence Addressing the Diagnosis, Prognosis, and Management of Peripheral Artery Disease in Patients With Diabetic Foot Ulceration. ( 29909087 )
2018
22
Environment-wide association study to identify novel factors associated with peripheral arterial disease: Evidence from the National Health and Nutrition Examination Survey (1999-2004). ( 29366990 )
2018
23
Improvement of the Quality of Evidence of Peripheral Artery Disease in Diabetic Foot Ulceration: Small Step for a Doctor, Giant Leap for Mankind? ( 29898825 )
2018
24
A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease. ( 29888052 )
2018
25
The role of magnetic resonance angiography in peripheral artery disease. ( 29860155 )
2018
26
Peripheral artery disease and transcatheter aortic valve implantation: The tip of the atherosclerotic iceberg. ( 29425563 )
2018
27
Epidemiology of peripheral artery disease in Europe: VAS Educational Paper. ( 29936722 )
2018
28
Risk of peripheral artery disease according to a healthy lifestyle score: The PREDIMED study. ( 29902701 )
2018
29
Protecting Life and Limb in Peripheral Artery Disease. ( 29358343 )
2018
30
Editorial overview: Cardiovascular and renal: Novel therapies in peripheral artery disease. ( 29941177 )
2018
31
Toe-brachial index and exercise test can improve the exploration of peripheral artery disease. ( 29366987 )
2018
32
Peripheral artery disease is associated with frailty in chronic hemodialysis patients. ( 29402196 )
2018
33
Diagnostic accuracy of the postexercise ankle-brachial index for detecting peripheral artery disease in suspected claudicants with and without diabetes. ( 29432708 )
2018
34
Burden of Peripheral Artery Disease in Sub-Saharan Africa and the Caribbean 1990 to 2015. ( 29945494 )
2018
35
Update on peripheral artery disease: Epidemiology and evidence-based facts. ( 29843915 )
2018
36
Joint moment strategies during stair descent in patients with peripheral arterial disease and intermittent claudication. ( 29625411 )
2018
37
Effectiveness and Safety of Anticoagulants in Adults with Non-valvular Atrial Fibrillation and Concomitant Coronary/Peripheral Artery Disease. ( 29807001 )
2018
38
Cost-effectiveness analysis of asymptomatic peripheral artery disease screening with the ABI test. ( 29345540 )
2018
39
Increased Risk of Peripheral Arterial Disease in Patients With Abdominal Aortic Aneurysm: A Retrospective Cohort Study (Version 5). ( 29444589 )
2018
40
Antithrombotic therapy in peripheral artery disease: A review of the EUCLID trial results and current ongoing trials. ( 29355992 )
2018
41
Low Plasma Levels of Fibroblast Growth Factor-21 in Patients with Peripheral Artery Disease. ( 29367522 )
2018
42
Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease. ( 28205274 )
2018
43
Antithrombotic Therapy for Peripheral Artery Disease in 2018. ( 29860284 )
2018
44
Impact of peripheral artery disease on early and late outcomes of transcatheter aortic valve implantation in patients with severe aortic valve stenosis. ( 29425561 )
2018
45
Peripheral artery disease. ( 29419394 )
2018
46
Ticagrelor for the prevention of ischemic events in patients with prior myocardial infarction and peripheral artery disease. ( 29893152 )
2018
47
Race and Socioeconomic Status Independently Affect Risk of Major Amputation in Peripheral Artery Disease. ( 29330260 )
2018
48
Angiopoietin-related growth factor is independently associated with lower extremity peripheral arterial disease. ( 27866700 )
2017
49
IL1RL1 single nucleotide polymorphism predicts sST2 level and mortality in coronary and peripheral artery disease. ( 28110258 )
2017
50
Acute and chronic effects of exercise on mRNA expression in the skeletal muscle of two mouse models of peripheral artery disease. ( 28771574 )
2017
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Variations for Peripheral Artery Disease

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Expression for Peripheral Artery Disease

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Search GEO for disease gene expression data for Peripheral Artery Disease.
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Pathways for Peripheral Artery Disease

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Pathways related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.77 APOB CCL2 CRP CST3 IL6 NLRP1
2
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways 65
Show member pathways
 12.48 CCL2 NOS3 VCAM1 VEGFA
3
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.15 CCL2 NOS3 VCAM1 VEGFA
4
Folate Metabolism 1
Show member pathways
 12.04 APOB CCL2 CRP IL6
5
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.88 IL6 VCAM1 VEGFA
6
Spinal Cord Injury 1
11.8 CCL2 IL6 SELP
7
Fluid shear stress and atherosclerosis 37
11.77 CCL2 NOS3 VCAM1 VEGFA
8
TNF signaling pathway 37
11.73 CCL2 IL6 VCAM1
9
HIF-1 signaling pathway 37
11.69 IL6 NOS3 VEGFA
10
Rheumatoid arthritis 37
11.63 CCL2 IL6 VEGFA
11
Interleukin-4 and 13 signaling 66
11.51 CCL2 IL6 VCAM1 VEGFA
12
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.41 IL6 VCAM1 VEGFA
13
amb2 Integrin signaling 1
11.23 APOB IL6 SELP
14
AGE-RAGE signaling pathway in diabetic complications 37
11.02 CCL2 IL6 NOS3 VCAM1 VEGFA
15
A-beta Pathways: Plaque Formation and APP Metabolism 65
10.97 ACE CST3
16
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
10.96 CCL2 IL6 NOS3
17
Malaria 37
10.95 CCL2 IL6 SELP VCAM1
18
Cellular roles of Anthrax toxin 1
10.94 NLRP1 VCAM1
19
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.85 CCL2 VEGFA
20
Overview of nanoparticle effects 1
10.85 CRP IL6
21
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits 1
10.79 VCAM1 VEGFA
22
LDL Oxidation in Atherogenesis 64
10.74 CCL2 VCAM1
Sources

GO Terms for Peripheral Artery Disease

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Cellular components related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ACE APOB CCL2 CRP CST3 IL6
2 endoplasmic reticulum lumen GO:0005788 9.56 APOB CST3 IL6 PCSK9
3 external side of plasma membrane GO:0009897 9.46 ACE P2RY12 SELP VCAM1
4 extracellular space GO:0005615 9.36 ACE APOB CCL2 CRP CST3 IL6

Biological processes related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.88 APOB CRP IL6 VEGFA
2 post-translational protein modification GO:0043687 9.85 APOB CST3 IL6 PCSK9
3 cytokine-mediated signaling pathway GO:0019221 9.8 CCL2 IL6 VCAM1 VEGFA
4 cellular response to tumor necrosis factor GO:0071356 9.73 APOB CCL2 VCAM1
5 kidney development GO:0001822 9.69 ACE PCSK9 VEGFA
6 regulation of signaling receptor activity GO:0010469 9.65 CCL2 IL6 PCSK9 TNFRSF11B VEGFA
7 cellular protein metabolic process GO:0044267 9.62 APOB CST3 IL6 PCSK9
8 positive regulation of receptor internalization GO:0002092 9.59 PCSK9 VEGFA
9 artery morphogenesis GO:0048844 9.58 APOB VEGFA
10 calcium-mediated signaling using intracellular calcium source GO:0035584 9.57 SELP VCAM1
11 leukocyte tethering or rolling GO:0050901 9.54 SELP VCAM1
12 response to inorganic substance GO:0010035 9.52 CST3 TNFRSF11B
13 positive regulation of leukocyte migration GO:0002687 9.48 SELP VEGFA
14 negative regulation of bone resorption GO:0045779 9.46 IL6 TNFRSF11B
15 response to carbohydrate GO:0009743 9.43 APOB CST3
16 neutrophil mediated immunity GO:0002446 9.4 ACE IL6
17 negative regulation of lipid storage GO:0010888 9.37 CRP IL6
18 response to lipopolysaccharide GO:0032496 9.35 APOB NOS3 SELP TNFRSF11B VCAM1
19 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.16 ACE VEGFA
20 inflammatory response GO:0006954 9.1 CCL2 CRP IL6 NLRP1 SELP TNFRSF11B

Molecular functions related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CCL2 IL6 TNFRSF11B VEGFA
2 low-density lipoprotein particle binding GO:0030169 9.16 CRP PCSK9
3 low-density lipoprotein particle receptor binding GO:0050750 8.8 APOB CRP PCSK9
Sources

Sources for Peripheral Artery Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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