Peripheral Nerve Schwannoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Peripheral Nerve Schwannoma

MalaCards integrated aliases for Peripheral Nerve Schwannoma:

Name: Peripheral Nerve Schwannoma ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:956

NCIt ⁵⁰ C41430

UMLS ⁷⁰ C1519001

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Summaries for Peripheral Nerve Schwannoma

MalaCards based summary : Peripheral Nerve Schwannoma is related to neurofibroma and neurilemmoma. An important gene associated with Peripheral Nerve Schwannoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is Transcription Ligand-dependent activation of the ESR1/SP pathway. Affiliated tissues include spinal cord, lymph node and brain, and related phenotypes are Increased proliferation and homeostasis/metabolism

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Related Diseases for Peripheral Nerve Schwannoma

Diseases related to Peripheral Nerve Schwannoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)

#	Related Disease	Score	Top Affiliating Genes
1	neurofibroma	29.9	NF2 NF1
2	neurilemmoma	29.7	SMARCB1 SERPINA3 NF2 NF1 LZTR1
3	peripheral nervous system disease	29.4	SERPINA3 NF2 NF1
4	intraorbital meningioma	10.2	NF2 LZTR1
5	olfactory groove meningioma	10.2	NF2 LZTR1
6	anterior cranial fossa meningioma	10.2	NF2 LZTR1
7	proliferative fasciitis	10.2	SMARCB1 SERPINA3
8	monosomy 22	10.2	SMARCB1 NF2
9	chondroid chordoma	10.2	SMARCB1 SERPINA3
10	melanotic neurilemmoma	10.2	SMARCB1 NF2
11	rhabdoid meningioma	10.1	SMARCB1 NF2
12	sweat gland benign neoplasm	10.1	SMARCB1 SERPINA3
13	mn1 c-terminal truncation syndrome	10.1	SMARCE1 NF2
14	angiomatous meningioma	10.1	SMARCE1 NF2
15	cerebral ventricle cancer	10.1	SMARCB1 NF2
16	cerebrum cancer	10.1	SMARCB1 NF2
17	pleomorphic xanthoastrocytoma	10.1	SMARCB1 SERPINA3
18	supratentorial cancer	10.1	SMARCB1 NF2
19	transitional meningioma	10.1	SMARCE1 NF2
20	spindle cell sarcoma	10.1	SERPINA3 NF2
21	synovium cancer	10.1	SMARCB1 SERPINA3
22	neurofibromatosis	10.1
23	benign meningioma	10.1	SMARCE1 NF2
24	coffin-siris syndrome 3	10.0	SMARCE1 SMARCB1
25	clark-baraitser syndrome	10.0	SMARCE1 SMARCB1
26	fibroma	10.0	SERPINA3 NF1
27	epithelioid neurofibroma	10.0	NF2 NF1
28	cerebellar astrocytoma	10.0	SERPINA3 NF1
29	cerebral falx meningioma	10.0	NF2 NF1
30	skull base cancer	10.0	SMARCE1 SERPINA3 NF2
31	small intestine leiomyoma	10.0	NF2 NF1
32	skull base meningioma	10.0	SMARCE1 SERPINA3 NF2
33	polyp of corpus uteri	10.0	NF2 NF1
34	meningothelial meningioma	10.0	SMARCE1 SERPINA3 NF2
35	schwannomatosis 1	10.0	SMARCB1 NF2 LZTR1
36	adult malignant schwannoma	10.0	NF2 NF1
37	orbital cancer	10.0	NF2 NF1
38	malignant spindle cell melanoma	10.0	SERPINA3 NF1
39	giant cell reparative granuloma	10.0	SERPINA3 NF1
40	adult xanthogranuloma	10.0	SERPINA3 NF1
41	rete ovarii adenoma	9.9	NF2 NF1
42	rete ovarii benign neoplasm	9.9	NF2 NF1
43	optic nerve glioma	9.9	NF2 NF1
44	neuropathy	9.9
45	soft tissue sarcoma	9.9
46	paresthesia	9.9
47	persistent generalized lymphadenopathy	9.9	SERPINA3 NF1
48	neurofibrosarcoma	9.9	NF2 NF1
49	optic nerve astrocytoma	9.9	SMARCB1 NF1
50	cellular neurofibroma	9.9	SMARCB1 NF1

Graphical network of the top 20 diseases related to Peripheral Nerve Schwannoma:

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Symptoms & Phenotypes for Peripheral Nerve Schwannoma

GenomeRNAi Phenotypes related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased proliferation	GR00094-A	8.62	NF2 SMARCB1

MGI Mouse Phenotypes related to Peripheral Nerve Schwannoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.7	LZTR1 NF1 NF2 PHYH SERPINA3 SMARCB1
2	liver/biliary system	MP:0005370	9.35	NF1 NF2 PHYH SMARCB1 SPTBN1
3	neoplasm	MP:0002006	8.92	NF1 NF2 SMARCB1 SPTBN1

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Drugs & Therapeutics for Peripheral Nerve Schwannoma

Search Clinical Trials , NIH Clinical Center for Peripheral Nerve Schwannoma

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Genetic Tests for Peripheral Nerve Schwannoma

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Anatomical Context for Peripheral Nerve Schwannoma

MalaCards organs/tissues related to Peripheral Nerve Schwannoma:

⁴⁰

Spinal Cord, Lymph Node, Brain, Skeletal Muscle, Small Intestine, Skin

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Publications for Peripheral Nerve Schwannoma

Articles related to Peripheral Nerve Schwannoma:

(show all 17)

#	Title	Authors	PMID	Year
1	Epineural glomus tumor of the posterior interosseous nerve: Case report. ⁶¹	Drabent P...Peyre M	31917057	2020
2	The effect of ozone injection within a common peroneal nerve schwannoma: A mistreatment due to a misdiagnosis. ⁶¹	Vetrano IG...Nazzi V	33365176	2020
3	[Surgical Technique for Peripheral Nerve Schwannoma Resection]. ⁶¹	Hara M...Yamamoto Y	31874942	2019
4	Extracapsular dissection in peripheral nerve schwannoma surgery using bright light and fluorescein sodium visualization: case series. ⁶¹	Kalamarides M...Peyre M	31679103	2019
5	Erdheim-Chester disease mimicking lumbar nerve schwannoma: case report and literature review. ⁶¹	Huang Z...Ye W	33122653	2019
6	Erdheim-Chester disease mimicking lumbar nerve schwannoma: case report and literature review. ⁶¹	Huang Z...Ye W	31700688	2019
7	Analysis of Peripheral Nerve Schwannoma Pseudocapsule. ⁶¹	Stone JJ...Spinner RJ	30114537	2018
8	Utility of intraoperative monitoring with motor-evoked potential during the surgical enucleation of peripheral nerve schwannoma. ⁶¹	Sasaki H...Komiya S	29844829	2018
9	Peripheral Nerve Schwannoma: A Review of Varying Clinical Presentations and Imaging Findings. ⁶¹	Albert P...Parnell J	28237565	2017
10	A Vascular Malformation Presenting as a Peripheral Nerve Sheath Tumor. ⁶¹	Parmar V...Hanna AS	28077959	2016
11	Commentary on: 'Comparison of outcomes of peripheral nerve schwannoma excision in neurofibromatosis type 2 patients and non-neurofibromatosis type 2 patients: A case control study'. ⁶¹	Hebert-Blouin MN...Spinner RJ	26070489	2015
12	Comparison of outcomes of peripheral nerve schwannoma excision in neurofibromatosis type 2 patients and non-neurofibromatosis type 2 patients: A case control study. ⁶¹	Bendon CL...Giele HP	26139580	2015
13	Preoperative localization of spinal and peripheral pathologies for surgery by computed tomography-guided placement of a specialized needle system. ⁶¹	Slotty P...Stummer W	20190662	2010
14	Fluid-fluid level in peripheral nerve schwannoma: report of a case with histological correlation. ⁶¹	Chang WC...Hsu YC	19411036	2009
15	Peripheral nerve schwannoma: two cases exhibiting increased FDG uptake in early and delayed PET imaging. ⁶¹	Hamada K...Hatazawa J	15480645	2005
16	Peripheral nerve schwannoma preoperatively diagnosed by sonography: report of three cases and discussion. ⁶¹	Simonovsky V	9248799	1997
17	Assessing sensory involvement in lower limb nerve lesions using somatosensory evoked potential techniques. ⁶¹	Synek VM	16758575	1985

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Genes for Peripheral Nerve Schwannoma

Genes related to Peripheral Nerve Schwannoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SERPINA3	Serpin Family A Member 3	Protein Coding	8.79	DISEASES inferred ¹⁵ ¹⁵
2	NF2	Neurofibromin 2	Protein Coding	6.79	DISEASES inferred ¹⁵
3	LZTR1	Leucine Zipper Like Transcription Regulator 1	Protein Coding	5.39	DISEASES inferred ¹⁵
4	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	5.21	DISEASES inferred ¹⁵
5	SMARCE1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1	Protein Coding	5.2	DISEASES inferred ¹⁵
6	PHYH	Phytanoyl-CoA 2-Hydroxylase	Protein Coding	5.15	DISEASES inferred ¹⁵
7	NF1	Neurofibromin 1	Protein Coding	5.09	DISEASES inferred ¹⁵
8	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	4.93	DISEASES inferred ¹⁵

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Variations for Peripheral Nerve Schwannoma

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Expression for Peripheral Nerve Schwannoma

Search GEO for disease gene expression data for Peripheral Nerve Schwannoma.

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Pathways for Peripheral Nerve Schwannoma

Pathways related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcription Ligand-dependent activation of the ESR1/SP pathway ²³ Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²³	10.47	SMARCE1 SMARCB1

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GO Terms for Peripheral Nerve Schwannoma

Cellular components related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear chromosome	GO:0000228	9.26	SMARCE1 SMARCB1
2	SWI/SNF complex	GO:0016514	9.16	SMARCE1 SMARCB1
3	nBAF complex	GO:0071565	8.96	SMARCE1 SMARCB1
4	npBAF complex	GO:0071564	8.62	SMARCE1 SMARCB1

Biological processes related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATP-dependent chromatin remodeling	GO:0043044	9.16	SMARCE1 SMARCB1
2	negative regulation of MAPK cascade	GO:0043409	8.96	NF2 NF1
3	nucleosome disassembly	GO:0006337	8.62	SMARCE1 SMARCB1

Molecular functions related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleosomal DNA binding	GO:0031492	8.62	SMARCE1 SMARCB1

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Sources for Peripheral Nerve Schwannoma

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