MCID: PRP018
MIFTS: 25

Peripheral Nerve Schwannoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Peripheral Nerve Schwannoma

MalaCards integrated aliases for Peripheral Nerve Schwannoma:

Name: Peripheral Nerve Schwannoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:956
NCIt 50 C41430
UMLS 70 C1519001

Summaries for Peripheral Nerve Schwannoma

MalaCards based summary : Peripheral Nerve Schwannoma is related to neurofibroma and neurilemmoma. An important gene associated with Peripheral Nerve Schwannoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is Transcription Ligand-dependent activation of the ESR1/SP pathway. Affiliated tissues include spinal cord, lymph node and brain, and related phenotypes are Increased proliferation and homeostasis/metabolism

Related Diseases for Peripheral Nerve Schwannoma

Diseases related to Peripheral Nerve Schwannoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 neurofibroma 29.9 NF2 NF1
2 neurilemmoma 29.7 SMARCB1 SERPINA3 NF2 NF1 LZTR1
3 peripheral nervous system disease 29.4 SERPINA3 NF2 NF1
4 intraorbital meningioma 10.2 NF2 LZTR1
5 olfactory groove meningioma 10.2 NF2 LZTR1
6 anterior cranial fossa meningioma 10.2 NF2 LZTR1
7 proliferative fasciitis 10.2 SMARCB1 SERPINA3
8 monosomy 22 10.2 SMARCB1 NF2
9 chondroid chordoma 10.2 SMARCB1 SERPINA3
10 melanotic neurilemmoma 10.2 SMARCB1 NF2
11 rhabdoid meningioma 10.1 SMARCB1 NF2
12 sweat gland benign neoplasm 10.1 SMARCB1 SERPINA3
13 mn1 c-terminal truncation syndrome 10.1 SMARCE1 NF2
14 angiomatous meningioma 10.1 SMARCE1 NF2
15 cerebral ventricle cancer 10.1 SMARCB1 NF2
16 cerebrum cancer 10.1 SMARCB1 NF2
17 pleomorphic xanthoastrocytoma 10.1 SMARCB1 SERPINA3
18 supratentorial cancer 10.1 SMARCB1 NF2
19 transitional meningioma 10.1 SMARCE1 NF2
20 spindle cell sarcoma 10.1 SERPINA3 NF2
21 synovium cancer 10.1 SMARCB1 SERPINA3
22 neurofibromatosis 10.1
23 benign meningioma 10.1 SMARCE1 NF2
24 coffin-siris syndrome 3 10.0 SMARCE1 SMARCB1
25 clark-baraitser syndrome 10.0 SMARCE1 SMARCB1
26 fibroma 10.0 SERPINA3 NF1
27 epithelioid neurofibroma 10.0 NF2 NF1
28 cerebellar astrocytoma 10.0 SERPINA3 NF1
29 cerebral falx meningioma 10.0 NF2 NF1
30 skull base cancer 10.0 SMARCE1 SERPINA3 NF2
31 small intestine leiomyoma 10.0 NF2 NF1
32 skull base meningioma 10.0 SMARCE1 SERPINA3 NF2
33 polyp of corpus uteri 10.0 NF2 NF1
34 meningothelial meningioma 10.0 SMARCE1 SERPINA3 NF2
35 schwannomatosis 1 10.0 SMARCB1 NF2 LZTR1
36 adult malignant schwannoma 10.0 NF2 NF1
37 orbital cancer 10.0 NF2 NF1
38 malignant spindle cell melanoma 10.0 SERPINA3 NF1
39 giant cell reparative granuloma 10.0 SERPINA3 NF1
40 adult xanthogranuloma 10.0 SERPINA3 NF1
41 rete ovarii adenoma 9.9 NF2 NF1
42 rete ovarii benign neoplasm 9.9 NF2 NF1
43 optic nerve glioma 9.9 NF2 NF1
44 neuropathy 9.9
45 soft tissue sarcoma 9.9
46 paresthesia 9.9
47 persistent generalized lymphadenopathy 9.9 SERPINA3 NF1
48 neurofibrosarcoma 9.9 NF2 NF1
49 optic nerve astrocytoma 9.9 SMARCB1 NF1
50 cellular neurofibroma 9.9 SMARCB1 NF1

Graphical network of the top 20 diseases related to Peripheral Nerve Schwannoma:



Diseases related to Peripheral Nerve Schwannoma

Symptoms & Phenotypes for Peripheral Nerve Schwannoma

GenomeRNAi Phenotypes related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Peripheral Nerve Schwannoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 LZTR1 NF1 NF2 PHYH SERPINA3 SMARCB1
2 liver/biliary system MP:0005370 9.35 NF1 NF2 PHYH SMARCB1 SPTBN1
3 neoplasm MP:0002006 8.92 NF1 NF2 SMARCB1 SPTBN1

Drugs & Therapeutics for Peripheral Nerve Schwannoma

Search Clinical Trials , NIH Clinical Center for Peripheral Nerve Schwannoma

Genetic Tests for Peripheral Nerve Schwannoma

Anatomical Context for Peripheral Nerve Schwannoma

MalaCards organs/tissues related to Peripheral Nerve Schwannoma:

40
Spinal Cord, Lymph Node, Brain, Skeletal Muscle, Small Intestine, Skin

Publications for Peripheral Nerve Schwannoma

Articles related to Peripheral Nerve Schwannoma:

(show all 17)
# Title Authors PMID Year
1
Epineural glomus tumor of the posterior interosseous nerve: Case report. 61
31917057 2020
2
The effect of ozone injection within a common peroneal nerve schwannoma: A mistreatment due to a misdiagnosis. 61
33365176 2020
3
[Surgical Technique for Peripheral Nerve Schwannoma Resection]. 61
31874942 2019
4
Extracapsular dissection in peripheral nerve schwannoma surgery using bright light and fluorescein sodium visualization: case series. 61
31679103 2019
5
Erdheim-Chester disease mimicking lumbar nerve schwannoma: case report and literature review. 61
33122653 2019
6
Erdheim-Chester disease mimicking lumbar nerve schwannoma: case report and literature review. 61
31700688 2019
7
Analysis of Peripheral Nerve Schwannoma Pseudocapsule. 61
30114537 2018
8
Utility of intraoperative monitoring with motor-evoked potential during the surgical enucleation of peripheral nerve schwannoma. 61
29844829 2018
9
Peripheral Nerve Schwannoma: A Review of Varying Clinical Presentations and Imaging Findings. 61
28237565 2017
10
A Vascular Malformation Presenting as a Peripheral Nerve Sheath Tumor. 61
28077959 2016
11
Commentary on: 'Comparison of outcomes of peripheral nerve schwannoma excision in neurofibromatosis type 2 patients and non-neurofibromatosis type 2 patients: A case control study'. 61
26070489 2015
12
Comparison of outcomes of peripheral nerve schwannoma excision in neurofibromatosis type 2 patients and non-neurofibromatosis type 2 patients: A case control study. 61
26139580 2015
13
Preoperative localization of spinal and peripheral pathologies for surgery by computed tomography-guided placement of a specialized needle system. 61
20190662 2010
14
Fluid-fluid level in peripheral nerve schwannoma: report of a case with histological correlation. 61
19411036 2009
15
Peripheral nerve schwannoma: two cases exhibiting increased FDG uptake in early and delayed PET imaging. 61
15480645 2005
16
Peripheral nerve schwannoma preoperatively diagnosed by sonography: report of three cases and discussion. 61
9248799 1997
17
Assessing sensory involvement in lower limb nerve lesions using somatosensory evoked potential techniques. 61
16758575 1985

Variations for Peripheral Nerve Schwannoma

Expression for Peripheral Nerve Schwannoma

Search GEO for disease gene expression data for Peripheral Nerve Schwannoma.

Pathways for Peripheral Nerve Schwannoma

Pathways related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.47 SMARCE1 SMARCB1

GO Terms for Peripheral Nerve Schwannoma

Cellular components related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 9.26 SMARCE1 SMARCB1
2 SWI/SNF complex GO:0016514 9.16 SMARCE1 SMARCB1
3 nBAF complex GO:0071565 8.96 SMARCE1 SMARCB1
4 npBAF complex GO:0071564 8.62 SMARCE1 SMARCB1

Biological processes related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent chromatin remodeling GO:0043044 9.16 SMARCE1 SMARCB1
2 negative regulation of MAPK cascade GO:0043409 8.96 NF2 NF1
3 nucleosome disassembly GO:0006337 8.62 SMARCE1 SMARCB1

Molecular functions related to Peripheral Nerve Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 8.62 SMARCE1 SMARCB1

Sources for Peripheral Nerve Schwannoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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