MCID: PRP105
MIFTS: 27

Peripheral Nervous System Benign Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Peripheral Nervous System Benign Neoplasm

MalaCards integrated aliases for Peripheral Nervous System Benign Neoplasm:

Name: Peripheral Nervous System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080320

Summaries for Peripheral Nervous System Benign Neoplasm

Disease Ontology : 12 A central nervous system benign neoplasm the is located in the peripheral nervous system.

MalaCards based summary : Peripheral Nervous System Benign Neoplasm is related to autonomic nervous system benign neoplasm and malignant melanocytic neoplasm of the peripheral nerve sheath. An important gene associated with Peripheral Nervous System Benign Neoplasm is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include peripheral nervous system, thyroid and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Peripheral Nervous System Benign Neoplasm

Diseases in the Peripheral Nervous System Neoplasm family:

Peripheral Nervous System Benign Neoplasm

Diseases related to Peripheral Nervous System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
# Related Disease Score Top Affiliating Genes
1 autonomic nervous system benign neoplasm 27.5 VIP TMEM127 TH SYP SST SDHD
2 malignant melanocytic neoplasm of the peripheral nerve sheath 10.4 SYP ENO2
3 desmoplastic infantile ganglioglioma 10.4 SYP MYCN
4 pacinian tumor 10.4 NF1 ENO2
5 cerebral neuroblastoma 10.4 SYP ENO2
6 lung meningioma 10.4 SYP ENO2
7 sinonasal undifferentiated carcinoma 10.4 SYP ENO2
8 papillary tumor of the pineal region 10.4 SYP ENO2
9 cerebral falx meningioma 10.4 NF1 ENO2
10 vaginal glandular tumor 10.4 ENO2 CHGA
11 cloacogenic carcinoma 10.4 SYP ENO2
12 retroperitoneal neuroblastoma 10.4 MYCN ENO2
13 pineal region teratoma 10.4 SYP ENO2
14 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.4 SYP ENO2
15 ureter transitional cell carcinoma 10.4 ENO2 CHGA
16 intracranial primitive neuroectodermal tumor 10.4 SYP ENO2
17 bile duct mucinous adenocarcinoma 10.4 SYP ENO2
18 nodular prostate 10.4 SYP ENO2
19 cerebellar liponeurocytoma 10.4 SYP ENO2
20 cerebellopontine angle primitive neuroectodermal tumor 10.4 SYP ENO2
21 gastric gastrinoma 10.4 ENO2 CHGA
22 primary hepatic neuroendocrine carcinoma 10.4 SYP CHGA
23 esophageal neuroendocrine tumor 10.4 SYP CHGA
24 jejunal neoplasm 10.4 SYP ENO2
25 skin lipoma 10.4 RET NF1
26 acinar cell cystadenocarcinoma 10.4 SYP CHGA
27 vulvar eccrine porocarcinoma 10.4 SYP CHGA
28 pancreatic serous cystadenocarcinoma 10.4 SYP CHGA
29 plexiform schwannoma 10.4 NF1 ENO2
30 goblet cell carcinoid 10.4 ENO2 CHGA
31 vaginal tubulovillous adenoma 10.4 SYP CHGA
32 mixed ductal-endocrine carcinoma 10.4 SYP CHGA
33 ewing sarcoma of bone 10.4 ENO2 CHGA
34 laryngeal small cell carcinoma 10.4 SYP CHGA
35 papillary thymic adenocarcinoma 10.4 SYP CHGA
36 neonatal hypoxic and ischemic brain injury 10.4 TH ENO2
37 breast papillary carcinoma 10.4 SYP CHGA
38 myoblastoma 10.4 SYP ENO2
39 pineal parenchymal tumor of intermediate differentiation 10.4 SYP ENO2
40 frontal lobe neoplasm 10.4 SYP MYCN ENO2
41 optic nerve astrocytoma 10.4 SYP NF1 ENO2
42 central nervous system primitive neuroectodermal neoplasm 10.3 SYP MYCN ENO2
43 ependymoblastoma 10.3 SYP MYCN ENO2
44 spinal cord oligodendroglioma 10.3 SYP NF1 ENO2
45 orbital cancer 10.3 SYP NF1 ENO2
46 esophageal adenoid cystic carcinoma 10.3 SYP CHGA
47 kidney rhabdoid cancer 10.3 SYP ENO2
48 neuronal intestinal dysplasia, type b 10.3 SYP RET ENO2
49 subungual glomus tumor 10.3 SYP NF1
50 appendix adenocarcinoma 10.3 SYP CHGA

Graphical network of the top 20 diseases related to Peripheral Nervous System Benign Neoplasm:



Diseases related to Peripheral Nervous System Benign Neoplasm

Symptoms & Phenotypes for Peripheral Nervous System Benign Neoplasm

GenomeRNAi Phenotypes related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.05 NF1 NTRK2 RET SDHD
2 Decreased viability GR00221-A-2 10.05 MAX NF1 NTRK2 RET SDHD
3 Decreased viability GR00221-A-3 10.05 MAX NTRK1
4 Decreased viability GR00221-A-4 10.05 NF1 NTRK2 RET SDHD
5 Decreased viability GR00240-S-1 10.05 SDHB SST
6 Decreased viability GR00249-S 10.05 NF1 NTRK1 PNMT SDHD
7 Decreased viability GR00301-A 10.05 NTRK1 RET
8 Decreased viability GR00381-A-1 10.05 CALCA SDHD
9 Decreased viability GR00386-A-1 10.05 MAX NF1 SYP TMEM127
10 Decreased viability GR00402-S-2 10.05 ENO2 RET TMEM127

MGI Mouse Phenotypes related to Peripheral Nervous System Benign Neoplasm:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.37 ENO2 KIF1B MYCN NF1 NTRK1 NTRK2
2 growth/size/body region MP:0005378 10.28 CHGA ENO2 KDM4C KIF1B MAX MYCN
3 homeostasis/metabolism MP:0005376 10.28 CHGA KDM4C KIF1B MYCN NF1 NTRK2
4 mortality/aging MP:0010768 10.24 CHGA KDM4C KIF1B MAX MYCN NF1
5 cellular MP:0005384 10.22 ENO2 KDM4C MAX MYCN NF1 NTRK2
6 nervous system MP:0003631 10.17 CHGA ENO2 KIF1B MYCN NF1 NTRK1
7 endocrine/exocrine gland MP:0005379 10.11 CHGA KDM4C NF1 NTRK2 RET SDHB
8 normal MP:0002873 9.97 MYCN NF1 NTRK1 NTRK2 PHOX2B PNMT
9 no phenotypic analysis MP:0003012 9.91 CHGA KDM4C MYCN NTRK1 RET SDHB
10 respiratory system MP:0005388 9.61 ENO2 KIF1B MYCN NF1 NTRK2 PHOX2B
11 vision/eye MP:0005391 9.28 MYCN NF1 NTRK1 NTRK2 PHOX2B PNMT

Drugs & Therapeutics for Peripheral Nervous System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Peripheral Nervous System Benign Neoplasm

Genetic Tests for Peripheral Nervous System Benign Neoplasm

Anatomical Context for Peripheral Nervous System Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Peripheral Nervous System Benign Neoplasm:

19
Peripheral Nervous System

MalaCards organs/tissues related to Peripheral Nervous System Benign Neoplasm:

40
Thyroid, Lung, Breast, Appendix, Pineal, Brain, Kidney

Publications for Peripheral Nervous System Benign Neoplasm

Variations for Peripheral Nervous System Benign Neoplasm

Expression for Peripheral Nervous System Benign Neoplasm

Search GEO for disease gene expression data for Peripheral Nervous System Benign Neoplasm.

Pathways for Peripheral Nervous System Benign Neoplasm

GO Terms for Peripheral Nervous System Benign Neoplasm

Cellular components related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.77 VIP TH SYP KIF1B CALCA
2 neuronal cell body GO:0043025 9.73 TH SST RET NTRK1 ENO2 CALCA
3 early endosome GO:0005769 9.71 TMEM127 RET NTRK2 NTRK1
4 dendrite GO:0030425 9.5 TH RET NTRK2 NTRK1 NF1 MAX
5 terminal bouton GO:0043195 9.46 TH SYP NTRK2 CALCA
6 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.32 SDHD SDHB
7 axon GO:0030424 9.17 TH RET NTRK2 NTRK1 NF1 KIF1B

Biological processes related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.91 RET NTRK2 MYCN KIF1B KDM4C
2 negative regulation of cell proliferation GO:0008285 9.8 TMEM127 SST PHOX2B NTRK1 NF1
3 cerebral cortex development GO:0021987 9.67 TH NTRK2 NF1
4 positive regulation of kinase activity GO:0033674 9.65 RET NTRK2 NTRK1
5 retina development in camera-type eye GO:0060041 9.61 RET NTRK2 MAX
6 enteric nervous system development GO:0048484 9.52 RET PHOX2B
7 cellular response to nicotine GO:0071316 9.46 TH NTRK1
8 catecholamine biosynthetic process GO:0042423 9.37 TH PNMT
9 mechanoreceptor differentiation GO:0042490 9.32 NTRK2 NTRK1
10 neurotrophin signaling pathway GO:0038179 9.26 NTRK2 NTRK1
11 epinephrine biosynthetic process GO:0042418 9.16 TH PNMT
12 sympathetic nervous system development GO:0048485 9.13 PHOX2B NTRK1 NF1
13 cellular response to nerve growth factor stimulus GO:1990090 8.92 NTRK2 NTRK1 KIF1B CALCA

Molecular functions related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 RET NTRK2 NTRK1
2 ubiquinone binding GO:0048039 9.26 SDHD SDHB
3 neurotrophin binding GO:0043121 8.96 NTRK2 NTRK1
4 neurotrophin receptor activity GO:0005030 8.62 NTRK2 NTRK1

Sources for Peripheral Nervous System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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