MCID: PRP105
MIFTS: 24

Peripheral Nervous System Benign Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Peripheral Nervous System Benign Neoplasm

MalaCards integrated aliases for Peripheral Nervous System Benign Neoplasm:

Name: Peripheral Nervous System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080320

Summaries for Peripheral Nervous System Benign Neoplasm

MalaCards based summary : Peripheral Nervous System Benign Neoplasm is related to autonomic nervous system benign neoplasm and malignant melanocytic neoplasm of the peripheral nerve sheath. An important gene associated with Peripheral Nervous System Benign Neoplasm is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Carbon metabolism and Neuroscience. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Peripheral Nervous System Benign Neoplasm

Diseases in the Peripheral Nervous System Neoplasm family:

Peripheral Nervous System Benign Neoplasm

Diseases related to Peripheral Nervous System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 autonomic nervous system benign neoplasm 26.7 VIP TMEM127 TH SYP SST SDHD
2 malignant melanocytic neoplasm of the peripheral nerve sheath 10.6 SYP ENO2
3 desmoplastic infantile ganglioglioma 10.6 SYP MYCN
4 sinonasal undifferentiated carcinoma 10.6 SYP ENO2
5 cerebral neuroblastoma 10.6 SYP ENO2
6 retroperitoneal neuroblastoma 10.6 MYCN ENO2
7 papillary tumor of the pineal region 10.5 SYP ENO2
8 pineal region teratoma 10.5 SYP ENO2
9 pacinian tumor 10.5 NF1 ENO2
10 intracranial primitive neuroectodermal tumor 10.5 SYP ENO2
11 bile duct mucinous adenocarcinoma 10.5 SYP ENO2
12 vaginal glandular tumor 10.5 ENO2 CHGA
13 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.5 SYP ENO2
14 cerebellopontine angle primitive neuroectodermal tumor 10.5 SYP ENO2
15 nodular prostate 10.5 SYP ENO2
16 cerebral primitive neuroectodermal tumor 10.5 SYP MYCN
17 skin lipoma 10.5 RET GNS
18 ureter transitional cell carcinoma 10.5 ENO2 CHGA
19 primary hepatic neuroendocrine carcinoma 10.5 SYP CHGA
20 cerebellar liponeurocytoma 10.5 SYP ENO2
21 plexiform schwannoma 10.5 NF1 ENO2
22 acinar cell cystadenocarcinoma 10.5 SYP CHGA
23 papillary ependymoma 10.5 SYP ENO2
24 vulvar eccrine porocarcinoma 10.5 SYP CHGA
25 jejunal neoplasm 10.5 SYP ENO2
26 cervical large cell neuroendocrine carcinoma 10.5 SYP CHGA
27 mixed ductal-endocrine carcinoma 10.5 SYP CHGA
28 goblet cell carcinoid 10.5 ENO2 CHGA
29 esophageal neuroendocrine tumor 10.5 SYP CHGA
30 pancreatic serous cystadenocarcinoma 10.5 SYP CHGA
31 gastric gastrinoma 10.5 ENO2 CHGA
32 neonatal hypoxic and ischemic brain injury 10.5 TH ENO2
33 vaginal tubulovillous adenoma 10.5 SYP CHGA
34 frontal lobe neoplasm 10.5 SYP MYCN ENO2
35 myoblastoma 10.5 SYP ENO2
36 papillary thymic adenocarcinoma 10.5 SYP CHGA
37 malignant triton tumor 10.5 NF1 ENO2
38 breast papillary carcinoma 10.5 SYP CHGA
39 pineal parenchymal tumor of intermediate differentiation 10.5 SYP ENO2
40 ewing sarcoma of bone 10.5 ENO2 CHGA
41 central nervous system primitive neuroectodermal neoplasm 10.5 SYP MYCN ENO2
42 ependymoblastoma 10.5 SYP MYCN ENO2
43 optic nerve astrocytoma 10.5 SYP NF1 ENO2
44 laryngeal small cell carcinoma 10.5 SYP CHGA
45 cerebrum cancer 10.5 SYP MYCN ENO2
46 esophageal adenoid cystic carcinoma 10.5 SYP CHGA
47 cerebral ventricle cancer 10.5 SYP MYCN ENO2
48 orbital cancer 10.4 SYP NF1 ENO2
49 spinal cord oligodendroglioma 10.4 SYP NF1 ENO2
50 supratentorial cancer 10.4 SYP MYCN ENO2

Graphical network of the top 20 diseases related to Peripheral Nervous System Benign Neoplasm:



Diseases related to Peripheral Nervous System Benign Neoplasm

Symptoms & Phenotypes for Peripheral Nervous System Benign Neoplasm

GenomeRNAi Phenotypes related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.95 ALK NF1 NTRK2 RET SDHD
2 Decreased viability GR00221-A-2 9.95 NF1 NTRK2 RET SDHD
3 Decreased viability GR00221-A-4 9.95 ALK NF1 NTRK2 RET SDHD
4 Decreased viability GR00249-S 9.95 ALK NF1 SDHD
5 Decreased viability GR00301-A 9.95 RET
6 Decreased viability GR00381-A-1 9.95 SDHD
7 Decreased viability GR00386-A-1 9.95 NF1
8 Decreased viability GR00402-S-2 9.95 RET

MGI Mouse Phenotypes related to Peripheral Nervous System Benign Neoplasm:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.39 ALK ENO2 GNS MYCN NF1 NTRK1
2 homeostasis/metabolism MP:0005376 10.31 ALK CHGA KDM4C MYCN NF1 NTRK2
3 mortality/aging MP:0010768 10.31 ALK CHGA GNS KDM4C MYCN NF1
4 growth/size/body region MP:0005378 10.3 ALK CHGA ENO2 KDM4C MYCN NF1
5 cellular MP:0005384 10.24 ENO2 GNS KDM4C MYCN NF1 NTRK2
6 endocrine/exocrine gland MP:0005379 10.18 ALK CHGA KDM4C NF1 NTRK2 RET
7 nervous system MP:0003631 10.17 ALK CHGA ENO2 GNS MYCN NF1
8 normal MP:0002873 9.93 MYCN NF1 NTRK1 NTRK2 PHOX2B RET
9 neoplasm MP:0002006 9.91 ALK KDM4C NF1 RET SDHB SDHD
10 no phenotypic analysis MP:0003012 9.91 CHGA KDM4C MYCN NTRK1 RET SDHB
11 respiratory system MP:0005388 9.61 ALK ENO2 MYCN NF1 NTRK2 PHOX2B
12 vision/eye MP:0005391 9.28 ALK MYCN NF1 NTRK1 NTRK2 PHOX2B

Drugs & Therapeutics for Peripheral Nervous System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Peripheral Nervous System Benign Neoplasm

Genetic Tests for Peripheral Nervous System Benign Neoplasm

Anatomical Context for Peripheral Nervous System Benign Neoplasm

Publications for Peripheral Nervous System Benign Neoplasm

Variations for Peripheral Nervous System Benign Neoplasm

Expression for Peripheral Nervous System Benign Neoplasm

Search GEO for disease gene expression data for Peripheral Nervous System Benign Neoplasm.

Pathways for Peripheral Nervous System Benign Neoplasm

GO Terms for Peripheral Nervous System Benign Neoplasm

Cellular components related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.77 TH RET NTRK2 NTRK1 NF1
2 neuronal cell body GO:0043025 9.73 TH SST RET NTRK1 ENO2 CALCA
3 early endosome GO:0005769 9.71 TMEM127 RET NTRK2 NTRK1
4 axon GO:0030424 9.63 TH RET NTRK2 NTRK1 NF1 CALCA
5 receptor complex GO:0043235 9.62 RET NTRK2 NTRK1 ALK
6 terminal bouton GO:0043195 9.26 TH SYP NTRK2 CALCA
7 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHD SDHB SDHA

Biological processes related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.92 TMEM127 SST PHOX2B NTRK1 NF1
2 nervous system development GO:0007399 9.8 SDHA RET PHOX2B NTRK2 NTRK1 ALK
3 peptidyl-tyrosine phosphorylation GO:0018108 9.73 RET NTRK2 NTRK1 ALK
4 cerebral cortex development GO:0021987 9.72 TH NTRK2 NF1
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.67 RET NTRK2 NTRK1 ALK
6 cellular response to nerve growth factor stimulus GO:1990090 9.63 NTRK2 NTRK1 CALCA
7 tricarboxylic acid cycle GO:0006099 9.58 SDHD SDHB SDHA
8 enteric nervous system development GO:0048484 9.57 RET PHOX2B
9 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 9.56 RET NF1
10 cellular response to nicotine GO:0071316 9.54 TH NTRK1
11 succinate metabolic process GO:0006105 9.51 SDHB SDHA
12 mechanoreceptor differentiation GO:0042490 9.49 NTRK2 NTRK1
13 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.48 SDHD SDHA
14 regulation of MAPK cascade GO:0043408 9.33 NTRK2 NTRK1 NF1
15 neurotrophin signaling pathway GO:0038179 9.26 NTRK2 NTRK1
16 positive regulation of kinase activity GO:0033674 9.26 RET NTRK2 NTRK1 ALK
17 sympathetic nervous system development GO:0048485 8.8 PHOX2B NTRK1 NF1

Molecular functions related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.61 SDHD SDHB SDHA
2 ubiquinone binding GO:0048039 9.4 SDHD SDHB
3 neurotrophin binding GO:0043121 9.37 NTRK2 NTRK1
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.32 SDHB SDHA
5 neurotrophin receptor activity GO:0005030 9.26 NTRK2 NTRK1
6 protein tyrosine kinase activity GO:0004713 9.26 RET NTRK2 NTRK1 ALK
7 succinate dehydrogenase activity GO:0000104 9.16 SDHD SDHA
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 RET NTRK2 NTRK1 ALK

Sources for Peripheral Nervous System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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