Peripheral Nervous System Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Peripheral Nervous System Benign Neoplasm

MalaCards integrated aliases for Peripheral Nervous System Benign Neoplasm:

Name: Peripheral Nervous System Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080320

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Summaries for Peripheral Nervous System Benign Neoplasm

MalaCards based summary : Peripheral Nervous System Benign Neoplasm is related to autonomic nervous system benign neoplasm and malignant melanocytic neoplasm of the peripheral nerve sheath. An important gene associated with Peripheral Nervous System Benign Neoplasm is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Carbon metabolism and Neuroscience. Related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Peripheral Nervous System Benign Neoplasm

Diseases in the Peripheral Nervous System Neoplasm family:

Peripheral Nervous System Benign Neoplasm

Diseases related to Peripheral Nervous System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)

#	Related Disease	Score	Top Affiliating Genes
1	autonomic nervous system benign neoplasm	26.7	VIP TMEM127 TH SYP SST SDHD
2	malignant melanocytic neoplasm of the peripheral nerve sheath	10.6	SYP ENO2
3	desmoplastic infantile ganglioglioma	10.6	SYP MYCN
4	sinonasal undifferentiated carcinoma	10.6	SYP ENO2
5	cerebral neuroblastoma	10.6	SYP ENO2
6	retroperitoneal neuroblastoma	10.6	MYCN ENO2
7	papillary tumor of the pineal region	10.5	SYP ENO2
8	pineal region teratoma	10.5	SYP ENO2
9	pacinian tumor	10.5	NF1 ENO2
10	intracranial primitive neuroectodermal tumor	10.5	SYP ENO2
11	bile duct mucinous adenocarcinoma	10.5	SYP ENO2
12	vaginal glandular tumor	10.5	ENO2 CHGA
13	extraosseous ewings sarcoma-primitive neuroepithelial tumor	10.5	SYP ENO2
14	cerebellopontine angle primitive neuroectodermal tumor	10.5	SYP ENO2
15	nodular prostate	10.5	SYP ENO2
16	cerebral primitive neuroectodermal tumor	10.5	SYP MYCN
17	skin lipoma	10.5	RET GNS
18	ureter transitional cell carcinoma	10.5	ENO2 CHGA
19	primary hepatic neuroendocrine carcinoma	10.5	SYP CHGA
20	cerebellar liponeurocytoma	10.5	SYP ENO2
21	plexiform schwannoma	10.5	NF1 ENO2
22	acinar cell cystadenocarcinoma	10.5	SYP CHGA
23	papillary ependymoma	10.5	SYP ENO2
24	vulvar eccrine porocarcinoma	10.5	SYP CHGA
25	jejunal neoplasm	10.5	SYP ENO2
26	cervical large cell neuroendocrine carcinoma	10.5	SYP CHGA
27	mixed ductal-endocrine carcinoma	10.5	SYP CHGA
28	goblet cell carcinoid	10.5	ENO2 CHGA
29	esophageal neuroendocrine tumor	10.5	SYP CHGA
30	pancreatic serous cystadenocarcinoma	10.5	SYP CHGA
31	gastric gastrinoma	10.5	ENO2 CHGA
32	neonatal hypoxic and ischemic brain injury	10.5	TH ENO2
33	vaginal tubulovillous adenoma	10.5	SYP CHGA
34	frontal lobe neoplasm	10.5	SYP MYCN ENO2
35	myoblastoma	10.5	SYP ENO2
36	papillary thymic adenocarcinoma	10.5	SYP CHGA
37	malignant triton tumor	10.5	NF1 ENO2
38	breast papillary carcinoma	10.5	SYP CHGA
39	pineal parenchymal tumor of intermediate differentiation	10.5	SYP ENO2
40	ewing sarcoma of bone	10.5	ENO2 CHGA
41	central nervous system primitive neuroectodermal neoplasm	10.5	SYP MYCN ENO2
42	ependymoblastoma	10.5	SYP MYCN ENO2
43	optic nerve astrocytoma	10.5	SYP NF1 ENO2
44	laryngeal small cell carcinoma	10.5	SYP CHGA
45	cerebrum cancer	10.5	SYP MYCN ENO2
46	esophageal adenoid cystic carcinoma	10.5	SYP CHGA
47	cerebral ventricle cancer	10.5	SYP MYCN ENO2
48	orbital cancer	10.4	SYP NF1 ENO2
49	spinal cord oligodendroglioma	10.4	SYP NF1 ENO2
50	supratentorial cancer	10.4	SYP MYCN ENO2

Graphical network of the top 20 diseases related to Peripheral Nervous System Benign Neoplasm:

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Symptoms & Phenotypes for Peripheral Nervous System Benign Neoplasm

GenomeRNAi Phenotypes related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	9.95	ALK NF1 NTRK2 RET SDHD
2	Decreased viability	GR00221-A-2	9.95	NF1 NTRK2 RET SDHD
3	Decreased viability	GR00221-A-4	9.95	ALK NF1 NTRK2 RET SDHD
4	Decreased viability	GR00249-S	9.95	ALK NF1 SDHD
5	Decreased viability	GR00301-A	9.95	RET
6	Decreased viability	GR00381-A-1	9.95	SDHD
7	Decreased viability	GR00386-A-1	9.95	NF1
8	Decreased viability	GR00402-S-2	9.95	RET

MGI Mouse Phenotypes related to Peripheral Nervous System Benign Neoplasm:

⁴⁵ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.39	ALK ENO2 GNS MYCN NF1 NTRK1
2	homeostasis/metabolism	MP:0005376	10.31	ALK CHGA KDM4C MYCN NF1 NTRK2
3	mortality/aging	MP:0010768	10.31	ALK CHGA GNS KDM4C MYCN NF1
4	growth/size/body region	MP:0005378	10.3	ALK CHGA ENO2 KDM4C MYCN NF1
5	cellular	MP:0005384	10.24	ENO2 GNS KDM4C MYCN NF1 NTRK2
6	endocrine/exocrine gland	MP:0005379	10.18	ALK CHGA KDM4C NF1 NTRK2 RET
7	nervous system	MP:0003631	10.17	ALK CHGA ENO2 GNS MYCN NF1
8	normal	MP:0002873	9.93	MYCN NF1 NTRK1 NTRK2 PHOX2B RET
9	neoplasm	MP:0002006	9.91	ALK KDM4C NF1 RET SDHB SDHD
10	no phenotypic analysis	MP:0003012	9.91	CHGA KDM4C MYCN NTRK1 RET SDHB
11	respiratory system	MP:0005388	9.61	ALK ENO2 MYCN NF1 NTRK2 PHOX2B
12	vision/eye	MP:0005391	9.28	ALK MYCN NF1 NTRK1 NTRK2 PHOX2B

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Drugs & Therapeutics for Peripheral Nervous System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Peripheral Nervous System Benign Neoplasm

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Genetic Tests for Peripheral Nervous System Benign Neoplasm

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Anatomical Context for Peripheral Nervous System Benign Neoplasm

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Publications for Peripheral Nervous System Benign Neoplasm

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Genes for Peripheral Nervous System Benign Neoplasm

Genes related to Peripheral Nervous System Benign Neoplasm (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYCN	MYCN Proto-Oncogene, BHLH Transcription Factor	Protein Coding	8.39	DISEASES inferred ¹⁵
2	GNS	Glucosamine (N-Acetyl)-6-Sulfatase	Protein Coding	8.03	DISEASES inferred ¹⁵
3	ENO2	Enolase 2	Protein Coding	7.36	DISEASES inferred ¹⁵
4	NF1	Neurofibromin 1	Protein Coding	7.2	DISEASES inferred ¹⁵
5	PHOX2B	Paired Like Homeobox 2B	Protein Coding	7.09	DISEASES inferred ¹⁵
6	SYP	Synaptophysin	Protein Coding	7.06	DISEASES inferred ¹⁵
7	RET	Ret Proto-Oncogene	Protein Coding	7.03	DISEASES inferred ¹⁵
8	VIP	Vasoactive Intestinal Peptide	Protein Coding	6.93	DISEASES inferred ¹⁵
9	CHGA	Chromogranin A	Protein Coding	6.82	DISEASES inferred ¹⁵
10	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	6.55	DISEASES inferred ¹⁵
11	KDM4C	Lysine Demethylase 4C	Protein Coding	6.53	DISEASES inferred ¹⁵ ¹⁵
12	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	5.97	DISEASES inferred ¹⁵
13	TH	Tyrosine Hydroxylase	Protein Coding	5.94	DISEASES inferred ¹⁵
14	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	5.94	DISEASES inferred ¹⁵
15	TMEM127	Transmembrane Protein 127	Protein Coding	5.92	DISEASES inferred ¹⁵
16	SST	Somatostatin	Protein Coding	5.76	DISEASES inferred ¹⁵
17	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	5.74	DISEASES inferred ¹⁵
18	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	5.7	DISEASES inferred ¹⁵
19	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	5.69	DISEASES inferred ¹⁵
20	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	5.67	DISEASES inferred ¹⁵
21	KIF1B	Kinesin Family Member 1B	Protein Coding	5.65	DISEASES inferred ¹⁵
22	POMC	Proopiomelanocortin	Protein Coding	5.57	DISEASES inferred ¹⁵

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Variations for Peripheral Nervous System Benign Neoplasm

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Expression for Peripheral Nervous System Benign Neoplasm

Search GEO for disease gene expression data for Peripheral Nervous System Benign Neoplasm.

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Pathways for Peripheral Nervous System Benign Neoplasm

Pathways related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Carbon metabolism ³⁶ Show member pathways 2-Oxocarboxylic acid metabolism ³⁶ Biosynthesis of amino acids ³⁶ formaldehyde oxidation ¹	11.95	SDHD SDHB SDHA ENO2
2	Neuroscience ⁴	11.86	VIP TH SYP RET NTRK2 NTRK1
3	Tyrosine Kinases / Adaptors ⁴	11.73	RET NTRK2 NTRK1 ALK
4	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.56	TH SST RET PHOX2B NTRK2
5	Citrate cycle (TCA cycle) ³⁶ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.47	SDHD SDHB SDHA ENO2
6	Activation of TRKA receptors ⁶⁵ Show member pathways NGF-independant TRKA activation ⁶⁵	10.41	NTRK2 NTRK1

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GO Terms for Peripheral Nervous System Benign Neoplasm

Cellular components related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	dendrite	GO:0030425	9.77	TH RET NTRK2 NTRK1 NF1
2	neuronal cell body	GO:0043025	9.73	TH SST RET NTRK1 ENO2 CALCA
3	early endosome	GO:0005769	9.71	TMEM127 RET NTRK2 NTRK1
4	axon	GO:0030424	9.63	TH RET NTRK2 NTRK1 NF1 CALCA
5	receptor complex	GO:0043235	9.62	RET NTRK2 NTRK1 ALK
6	terminal bouton	GO:0043195	9.26	TH SYP NTRK2 CALCA
7	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.8	SDHD SDHB SDHA

Biological processes related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell proliferation	GO:0008285	9.92	TMEM127 SST PHOX2B NTRK1 NF1
2	nervous system development	GO:0007399	9.8	SDHA RET PHOX2B NTRK2 NTRK1 ALK
3	peptidyl-tyrosine phosphorylation	GO:0018108	9.73	RET NTRK2 NTRK1 ALK
4	cerebral cortex development	GO:0021987	9.72	TH NTRK2 NF1
5	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.67	RET NTRK2 NTRK1 ALK
6	cellular response to nerve growth factor stimulus	GO:1990090	9.63	NTRK2 NTRK1 CALCA
7	tricarboxylic acid cycle	GO:0006099	9.58	SDHD SDHB SDHA
8	enteric nervous system development	GO:0048484	9.57	RET PHOX2B
9	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001241	9.56	RET NF1
10	cellular response to nicotine	GO:0071316	9.54	TH NTRK1
11	succinate metabolic process	GO:0006105	9.51	SDHB SDHA
12	mechanoreceptor differentiation	GO:0042490	9.49	NTRK2 NTRK1
13	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	9.48	SDHD SDHA
14	regulation of MAPK cascade	GO:0043408	9.33	NTRK2 NTRK1 NF1
15	neurotrophin signaling pathway	GO:0038179	9.26	NTRK2 NTRK1
16	positive regulation of kinase activity	GO:0033674	9.26	RET NTRK2 NTRK1 ALK
17	sympathetic nervous system development	GO:0048485	8.8	PHOX2B NTRK1 NF1

Molecular functions related to Peripheral Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	electron transfer activity	GO:0009055	9.61	SDHD SDHB SDHA
2	ubiquinone binding	GO:0048039	9.4	SDHD SDHB
3	neurotrophin binding	GO:0043121	9.37	NTRK2 NTRK1
4	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.32	SDHB SDHA
5	neurotrophin receptor activity	GO:0005030	9.26	NTRK2 NTRK1
6	protein tyrosine kinase activity	GO:0004713	9.26	RET NTRK2 NTRK1 ALK
7	succinate dehydrogenase activity	GO:0000104	9.16	SDHD SDHA
8	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.92	RET NTRK2 NTRK1 ALK

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