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MCID: PRP024
MIFTS: 29

Peripheral Osteosarcoma

Categories: Bone diseases, Cancer diseases
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Genes Tissues Related diseases Publications
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Aliases & Classifications for Peripheral Osteosarcoma

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MalaCards integrated aliases for Peripheral Osteosarcoma:

Name: Peripheral Osteosarcoma 11 14
Bone Surface Osteosarcoma 71
Surface Osteosarcoma 11

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:3374
NCIt 49 C7134
UMLS 71 C1332591
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Summaries for Peripheral Osteosarcoma

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MalaCards based summary: Peripheral Osteosarcoma, also known as bone surface osteosarcoma, is related to osteogenic sarcoma and conventional osteosarcoma. An important gene associated with Peripheral Osteosarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Signal Transduction and Cellular Senescence. Affiliated tissues include bone and lung, and related phenotypes are growth/size/body region and limbs/digits/tail
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Related Diseases for Peripheral Osteosarcoma

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Diseases related to Peripheral Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 osteogenic sarcoma 30.7 TP53 RUNX2 MDM2 CDK4
2 conventional osteosarcoma 29.7 USP6 SATB2 MDM2 COPS3 CDK4
3 periosteal osteogenic sarcoma 29.4 WWOX USP6 SATB2 MDM2 H3-3B
4 sarcoma 29.3 TSPAN31 TP53 MDM2 CDK4
5 parosteal osteosarcoma 29.2 SNRNP25 SATB2 MDM2 GNAS FRS2 EMILIN1
6 bone osteosarcoma 27.8 USP6 TP53 SNRNP25 SATB2 RUNX2 MDM2
7 kidney liposarcoma 10.3 MDM2 CDK4
8 mediastinum liposarcoma 10.3 MDM2 CDK4
9 infiltrating lipoma 10.3 MDM2 CDK4
10 spindle cell liposarcoma 10.3 MDM2 CDK4
11 pancreas sarcoma 10.3 MDM2 CDK4
12 chest wall lipoma 10.3 MDM2 CDK4
13 adult liposarcoma 10.3 MDM2 CDK4
14 lipoma of spermatic cord 10.3 MDM2 CDK4
15 inflammatory liposarcoma 10.3 MDM2 CDK4
16 malignant inflammatory fibrous histiocytoma 10.3 MDM2 CDK4
17 paratesticular lipoma 10.3 MDM2 CDK4
18 spindle cell lipoma 10.3 MDM2 CDK4
19 gastric liposarcoma 10.3 MDM2 CDK4
20 heart sarcoma 10.3 MDM2 CDK4
21 appendiceal neoplasm 10.2 SATB2 GNAS
22 fibrosarcomatous osteosarcoma 10.2 SATB2 MDM2
23 large intestine lipoma 10.2 MDM2 CDK4
24 lipoma of colon 10.2 MDM2 CDK4
25 infiltrating angiolipoma 10.2 MDM2 CDK4
26 esophagus verrucous carcinoma 10.2 TP53 MDM2
27 maxillary sinus adenocarcinoma 10.2 TP53 MDM2
28 extraosseous osteosarcoma 10.2 SATB2 MDM2 CDK4
29 li-fraumeni syndrome 1 10.1 TP53 SNRNP25
30 chondrosarcoma 10.1 RUNX2 MDM2 CDK4
31 oligodendroglioma 10.1 TP53 MDM2 CDK4
32 mixed liposarcoma 10.1 TP53 MDM2 CDK4
33 myxofibrosarcoma 10.1 TP53 MDM2 CDK4
34 skeletal muscle cancer 10.1 TP53 MDM2 CDK4
35 nodular malignant melanoma 10.1 TP53 CDK4
36 muscle cancer 10.1 TP53 MDM2 CDK4
37 malignant fibrous histiocytoma 10.1 TP53 MDM2 CDK4
38 villous adenoma 10.1 TP53 GNAS
39 appendix adenocarcinoma 10.1 TP53 SATB2 GNAS
40 appendix disease 10.1 TP53 SATB2 GNAS
41 leiomyosarcoma 10.1 TP53 MDM2 CDK4
42 rhabdomyosarcoma 2 10.1 TP53 MDM2 CDK4
43 appendix cancer 10.1 TP53 SATB2 GNAS
44 malignant giant cell tumor 10.1 SATB2 H3-3B
45 malignant peripheral nerve sheath tumor 10.1 TP53 MDM2 CDK4
46 dicer1 syndrome 10.1 TP53 GNAS
47 retinal cancer 10.1 TP53 MDM2 CDK4
48 li-fraumeni syndrome 10.0 TP53 MDM2 CDK4
49 skin melanoma 10.0 TP53 GNAS CDK4
50 salivary gland adenoid cystic carcinoma 10.0 TP53 MDM2

Graphical network of the top 20 diseases related to Peripheral Osteosarcoma:



Diseases related to Peripheral Osteosarcoma
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Symptoms & Phenotypes for Peripheral Osteosarcoma

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MGI Mouse Phenotypes related to Peripheral Osteosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.96 CDK4 COPS3 FRS2 GNAS H3-3B MDM2
2 limbs/digits/tail MP:0005371 9.8 FRS2 GNAS MDM2 RUNX2 SATB2 TP53
3 embryo MP:0005380 9.76 CDK4 COPS3 FRS2 GNAS H3-3B MDM2
4 craniofacial MP:0005382 9.5 CDK4 FRS2 GNAS MDM2 RUNX2 SATB2
5 cellular MP:0005384 9.28 CDK4 FRS2 GNAS H3-3B MDM2 RUNX2
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Drugs & Therapeutics for Peripheral Osteosarcoma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry) Not yet recruiting NCT05515068

Search NIH Clinical Center for Peripheral Osteosarcoma

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Genetic Tests for Peripheral Osteosarcoma

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Anatomical Context for Peripheral Osteosarcoma

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Organs/tissues related to Peripheral Osteosarcoma:

MalaCards : Bone, Lung
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Publications for Peripheral Osteosarcoma

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Articles related to Peripheral Osteosarcoma:

(show all 49)
# Title Authors PMID Year
1
A retrospective analysis of 11 dogs with surface osteosarcoma. 62
34033204 2022
2
Parosteal osteosarcoma with high-grade transformation and lung metastasis after 12 years: a rare presentation. 62
34898877 2022
3
Oncological and Functional Outcomes after Hemicortical Resection and Biological Reconstruction Using Allograft for Parosteal Osteosarcoma of the Distal Femur. 62
35692235 2022
4
Free Double-Barrel Vascularized Fibular Graft for Two-Bone Forearm Reconstruction After Tumor Resection: A Case Report. 62
35102023 2021
5
Surface osteosarcoma: Predictors of outcomes. 62
34043244 2021
6
Diaphyseal aneurysmal bone cysts (ABCs) of long bones in extremities: Analysis of surgical management and comparison with metaphyseal lesions. 62
33996452 2021
7
A review of imaging of surface sarcomas of bone. 62
32681279 2021
8
High-Grade Surface Osteosarcoma: Clinical Features and Oncologic Outcome. 62
32953434 2020
9
Parosteal Osteosarcoma: A Benign-Looking Tumour, Amenable to a Variety of Surgical Reconstruction. 62
32550023 2020
10
Low-Grade Surface Osteosarcoma of the Temporal Bone in Paediatric Patients: A Case Report and Literature Review. 62
31263376 2019
11
Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography: A case report. 62
29928362 2018
12
Surface osteosarcoma: Clinical features and therapeutic implications. 62
26730360 2015
13
High-grade surface osteosarcoma of the rib - a case report. 62
26277177 2015
14
Osteoma of long bone: an expanding spectrum of imaging findings. 62
25380570 2015
15
Post-traumatic heterotopic ossification of distal tibiofibular syndesmosis mimicking a surface osteosarcoma. 62
24034551 2013
16
A popliteal giant synovial osteochondroma mimicking a parosteal osteosarcoma. 62
24066980 2013
17
Novel oncologic, surgical, and prosthetic treatment of high-grade surface osteosarcoma, osteoblastic mandible type. 62
23298800 2013
18
Local recurrence of a parosteal osteosarcoma 21 years after incomplete resection. 62
22059909 2011
19
Periosteal osteoblastoma: Multimodal imaging of a rare neoplasm. 62
27307837 2009
20
High-grade surface osteosarcoma: a review of 25 cases from the Rizzoli Institute. 62
18300258 2008
21
High-grade surface osteosarcoma - chondroblastic type. 62
18356791 2007
22
High-grade surface osteosarcoma of the hand. 62
17410355 2007
23
[An aggressive chondroblastoma mimicking paraosteal osteosarcoma]. 62
18078282 2007
24
Hemicortical excision for low-grade selected surface sarcomas of bone. 62
17415008 2007
25
Surface osteosarcoma: 2 case reports. 62
16935183 2006
26
Pediatric surface osteosarcoma: clinical, pathologic, and radiologic features. 62
16123997 2006
27
Report of four cases with high-grade surface osteosarcoma. 62
16533804 2006
28
Pulmonary nodules in osteosarcoma patients: differential diagnosis of central venous catheter-related infections in the lungs. 62
16671377 2006
29
Skull osteosarcoma: illustrated review. 62
15340877 2004
30
Periosteal osteoblastoma of the distal femur. 62
14714148 2004
31
Multiple primary malignancies in osteosarcoma patients. Incidence and predictive value of osteosarcoma subtype for cancer syndromes related with osteosarcoma. 62
12891382 2003
32
High-grade surface osteosarcoma in a dog. 62
12779173 2003
33
Outcome of radiation-related osteosarcoma after treatment of childhood and adolescent cancer: a study of 23 cases. 62
10561354 1999
34
Dedifferentiated parosteal osteosarcoma with rhabdomyosarcomatous differentiation. 62
10525797 1999
35
High grade surface osteosarcoma: a clinicopathologic study of 46 cases. 62
10091787 1999
36
Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. 62
9771482 1998
37
Osteosarcoma of the larynx. 62
9439392 1998
38
SAS is amplified predominantly in surface osteosarcoma. 62
8893761 1996
39
High-grade surface osteosarcoma of the humerus. 62
8545652 1995
40
Case report: primary high grade surface osteosarcoma. 62
7889716 1995
41
New aspects in the treatment of bone sarcomas. 62
8587837 1994
42
Case report 795. High-grade surface osteosarcoma of the radius. 62
8372370 1993
43
High malignant surface osteosarcoma arising at the site of a previously treated aneurysmal bone cyst. 62
8491756 1993
44
"Tumoral" enthesopathy: a juxtacortical osteosarcoma simulation. 62
1765994 1991
45
Surface osteosarcoma. 62
1884533 1991
46
Osteosarcomas arising on the surfaces of long bones. 62
3281953 1988
47
High-grade surface osteosarcoma of the left ilium. A case report and review of the literature. 62
3164569 1988
48
Juxtacortical osteosarcoma: a radiologic and histologic spectrum. 62
3860961 1985
49
Case report 258. High-grade "surface" osteosarcoma arising from femoral shaft. 62
6584982 1984
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Variations for Peripheral Osteosarcoma

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Expression for Peripheral Osteosarcoma

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Search GEO for disease gene expression data for Peripheral Osteosarcoma.
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Pathways for Peripheral Osteosarcoma

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Pathways related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Signal Transduction 66
13.51 WWOX TP53 MDM2 H3-3B GNAS FRS2
2
Cellular Senescence 66
Show member pathways
 12.43 TP53 MDM2 H3-3B CDK4
3
DNA Damage 3
12.21 WWOX TP53 MDM2 CDK4
4
Cell cycle 74
Show member pathways
 12 TP53 MDM2 CDK4
5
p53 Signaling 64
Show member pathways
 11.94 TP53 MDM2 CDK4
6
Integrated breast cancer pathway 74
11.87 TP53 MDM2 CDK4
7
miRNA regulation of DNA damage response 74
Show member pathways
 11.79 CDK4 MDM2 TP53
8
Retinoblastoma gene in cancer 74
11.51 TP53 MDM2 CDK4
9
Thyroid hormones production and peripheral downstream signaling effects 74
11.46 TP53 MDM2 FRS2
10
Regulation of retinoblastoma protein 61
11.25 RUNX2 MDM2 CDK4
11
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
11.08 TP53 MDM2 CDK4
12
Bladder cancer 74
10.93 TP53 MDM2 CDK4
13
Inhibition of Ribosome Biogenesis by p14(ARF) 64
10.87 TP53 MDM2
14
TP53 network 74
Show member pathways
 10.78 TP53 MDM2
15
Integrated cancer pathway 74
10.71 TP53 MDM2 CDK4
16
Oncogene Induced Senescence 66
10.32 TP53 MDM2 CDK4
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GO Terms for Peripheral Osteosarcoma

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Cellular components related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulator complex GO:0005667 9.23 TP53 SATB2 RUNX2 CDK4

Biological processes related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cardiac septum morphogenesis GO:0060411 9.26 TP53 MDM2
2 cellular response to actinomycin D GO:0072717 8.92 TP53 MDM2
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Sources for Peripheral Osteosarcoma

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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