Peripheral Osteosarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Peripheral Osteosarcoma

MalaCards integrated aliases for Peripheral Osteosarcoma:

Name: Peripheral Osteosarcoma ¹² ¹⁵

Bone Surface Osteosarcoma ⁷³

Surface Osteosarcoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3374

NCIt ⁵⁰ C7134

UMLS ⁷³ C1332591

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Summaries for Peripheral Osteosarcoma

MalaCards based summary : Peripheral Osteosarcoma, also known as bone surface osteosarcoma, is related to ring chromosome 7 and undifferentiated embryonal sarcoma of the liver. An important gene associated with Peripheral Osteosarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Endometrial cancer and Development EGFR signaling pathway. Affiliated tissues include bone, and related phenotypes are behavior/neurological and cellular

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Related Diseases for Peripheral Osteosarcoma

Diseases related to Peripheral Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)

#	Related Disease	Score	Top Affiliating Genes
1	ring chromosome 7	10.8	CDK4 MDM2
2	undifferentiated embryonal sarcoma of the liver	10.8	CDK4 MDM2
3	infiltrating angiolipoma	10.8	CDK4 MDM2
4	spindle cell lipoma	10.8	CDK4 MDM2
5	extraosseous osteosarcoma	10.7	CDK4 MDM2
6	conventional central osteosarcoma	10.7	MDM2 SATB2
7	inflammatory mfh	10.7	CDK4 MDM2
8	lipoblastoma	10.7	CDK4 MDM2
9	malignant fibrous histiocytoma of bone	10.5	CDK4 FOS MDM2
10	mixed liposarcoma	10.5	CDK4 MDM2
11	bone osteosarcoma	10.3	CDK4 EMILIN1 MDM2 SATB2
12	multiple enchondromatosis, maffucci type	10.3	GNAS IDH1
13	lymph node cancer	10.3	FOS PLAUR
14	clear cell chondrosarcoma	10.2	PTHLH SPARC
15	pilocytic astrocytoma of cerebellum	10.2	GNAS IDH1
16	tooth ankylosis	10.2	PTHLH SPARC
17	melorheostosis	10.1	POSTN SPARC
18	ischemic fasciitis	10.1	CDK4 MDM2
19	small cell sarcoma	9.9	CDK4 HSP90AA1 MDM2
20	colorectal cancer	9.7
21	myelodysplastic syndrome	9.7
22	periosteal chondrosarcoma	9.6	CDK4 IDH1 MDM2 PTHLH
23	chondrosarcoma	9.5	IDH1 PTHLH SPARC
24	osteoporosis	9.1	FOS PTHLH SATB2 SPARC TGFB2
25	enchondromatosis, multiple, ollier type	9.1	HSP90AA1 IDH1 PTHLH
26	periosteal osteogenic sarcoma	9.0	CDK4 DACH1 FOS IDH1 MDM2 SATB2
27	juxtacortical osteosarcoma	5.2	CDK4 CLU CTSB EMILIN1 FABP3 FOS

Graphical network of the top 20 diseases related to Peripheral Osteosarcoma:

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Symptoms & Phenotypes for Peripheral Osteosarcoma

MGI Mouse Phenotypes related to Peripheral Osteosarcoma:

⁴⁶ (show all 18)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.39	PLAUR POSTN PTHLH SPARC CDK4 CLU
2	cellular	MP:0005384	10.37	CTSB DACH1 FABP3 FOS GNAS HSP90AA1
3	homeostasis/metabolism	MP:0005376	10.37	FABP3 FOS GNAS IDH1 MDM2 PLAUR
4	growth/size/body region	MP:0005378	10.34	MDM2 PLAUR POSTN PTHLH SATB2 SPARC
5	cardiovascular system	MP:0005385	10.31	CDK4 CLU EMILIN1 FABP3 GNAS MDM2
6	immune system	MP:0005387	10.29	CDK4 CLU CTSB FOS GNAS HSP90AA1
7	endocrine/exocrine gland	MP:0005379	10.28	CDK4 CTSB DACH1 FOS GNAS HSP90AA1
8	hematopoietic system	MP:0005397	10.25	CDK4 EMILIN1 FOS GNAS IDH1 MDM2
9	mortality/aging	MP:0010768	10.22	DACH1 FABP3 FOS GNAS HSP90AA1 IDH1
10	craniofacial	MP:0005382	10.2	FOS GNAS HSP90AA1 MDM2 POSTN PTHLH
11	limbs/digits/tail	MP:0005371	10.09	FOS GNAS HSP90AA1 MDM2 POSTN PTHLH
12	integument	MP:0010771	10.06	CDK4 CTSB EMILIN1 FOS GNAS MDM2
13	nervous system	MP:0003631	10	SATB2 TGFB2 FOS GNAS MDM2 PLAUR
14	muscle	MP:0005369	9.97	CDK4 CLU FABP3 GNAS MDM2 PLAUR
15	neoplasm	MP:0002006	9.87	SPARC CDK4 CTSB FOS GNAS MDM2
16	renal/urinary system	MP:0005367	9.76	CDK4 CLU CTSB GNAS MDM2 PLAUR
17	respiratory system	MP:0005388	9.5	DACH1 GNAS IDH1 PLAUR PTHLH SATB2
18	skeleton	MP:0005390	9.32	POSTN PTHLH SATB2 SPARC TGFB2 FOS

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Drugs & Therapeutics for Peripheral Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Peripheral Osteosarcoma

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Genetic Tests for Peripheral Osteosarcoma

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Anatomical Context for Peripheral Osteosarcoma

MalaCards organs/tissues related to Peripheral Osteosarcoma:

⁴¹

Bone

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Publications for Peripheral Osteosarcoma

Articles related to Peripheral Osteosarcoma:

#	Title	Authors	Year
1	Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2-[<sup>18</sup>F]-fluoro-2-deoxy-D-glucose positron emission tomography: A case report. ( 29928362 )	Maruyama N....Arasaki A.	2018
2	Post-traumatic heterotopic ossification of distal tibiofibular syndesmosis mimicking a surface osteosarcoma. ( 24034551 )	Botchu R....Grimer R.	2013
3	High-grade surface osteosarcoma - chondroblastic type. ( 18356791 )	Vasilevska V....Sapova B.	2007
4	Pediatric surface osteosarcoma: clinical, pathologic, and radiologic features. ( 16123997 )	Kaste S.C....Daw N.C.	2006
5	Report of four cases with high-grade surface osteosarcoma. ( 16533804 )	Hoshi M....Kawaguchi N.	2006
6	Submicroscopic and immunohistochemical profile of surface osteosarcomas. ( 10503742 )	Franchi A....Santucci M.	1999

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Genes for Peripheral Osteosarcoma

Genes related to Peripheral Osteosarcoma (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MDM2	MDM2 Proto-Oncogene	Protein Coding	16.57	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CDK4	Cyclin Dependent Kinase 4	Protein Coding	16.29	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	EMILIN1	Elastin Microfibril Interfacer 1	Protein Coding	16.2	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	GNAS	GNAS Complex Locus	Protein Coding	15.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	SATB2	SATB Homeobox 2	Protein Coding	14.96	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	DACH1	Dachshund Family Transcription Factor 1	Protein Coding	14.66	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	FABP3	Fatty Acid Binding Protein 3	Protein Coding	13.96	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	POSTN	Periostin	Protein Coding	13.88	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	SPARC	Secreted Protein Acidic And Cysteine Rich	Protein Coding	13.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	13.84	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	13.7	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	13.61	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	CLU	Clusterin	Protein Coding	13.44	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic	Protein Coding	13.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	CTSB	Cathepsin B	Protein Coding	13.33	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	13.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
17	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	13.1	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
18	WDFY2	WD Repeat And FYVE Domain Containing 2	Protein Coding	4	DISEASES inferred ¹⁵

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Variations for Peripheral Osteosarcoma

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Expression for Peripheral Osteosarcoma

Search GEO for disease gene expression data for Peripheral Osteosarcoma.

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Pathways for Peripheral Osteosarcoma

Pathways related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.51	CDK4 FOS HSP90AA1 MDM2 TGFB2
2	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.24	FOS HSP90AA1 MDM2 TGFB2
3	Pathways in cancer ³⁷	11.82	CDK4 FOS GNAS HSP90AA1 MDM2 TGFB2
4	Cell cycle Cell cycle (generic schema) ²² Show member pathways Cell cycle Regulation of G1/S transition (part 2) ²² G0 and Early G1 ⁶⁶ G2 Phase ⁶⁶	11.71	CDK4 FOS GNAS PLAUR
5	Parathyroid hormone synthesis, secretion and action ³⁷	11.63	FOS GNAS PTHLH
6	Corticotropin-releasing hormone signaling pathway ¹	11.55	FOS GNAS HSP90AA1
7	Glucocorticoid receptor regulatory network ¹	11.41	FOS HSP90AA1 MDM2
8	Human Thyroid Stimulating Hormone (TSH) signaling pathway ¹	11.27	CDK4 FOS GNAS
9	ATF-2 transcription factor network ¹	11.07	CDK4 FOS TGFB2
10	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	10.72	FOS GNAS PTHLH

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GO Terms for Peripheral Osteosarcoma

Cellular components related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.86	CLU CTSB EMILIN1 FABP3 POSTN PTHLH
2	perinuclear region of cytoplasm	GO:0048471	9.83	CDK4 CLU CTSB GNAS HSP90AA1
3	ficolin-1-rich granule lumen	GO:1904813	9.63	CTSB HSP90AA1 IDH1
4	extracellular matrix	GO:0031012	9.62	CLU EMILIN1 POSTN TGFB2
5	endocytic vesicle lumen	GO:0071682	9.37	HSP90AA1 SPARC
6	extracellular region	GO:0005576	9.36	CLU CTSB EMILIN1 GNAS HSP90AA1 IDH1
7	platelet alpha granule lumen	GO:0031093	9.33	CLU SPARC TGFB2
8	transcription factor complex	GO:0005667	9.26	CDK4 DACH1 FOS SATB2
9	cytoplasm	GO:0005737	10.22	CDK4 CLU DACH1 FABP3 FOS GNAS

Biological processes related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet degranulation	GO:0002576	9.72	CLU SPARC TGFB2
2	response to toxic substance	GO:0009636	9.67	CDK4 FOS MDM2
3	regulation of gene expression	GO:0010468	9.67	CDK4 MDM2 PTHLH SATB2
4	female pregnancy	GO:0007565	9.63	FOS GNAS PTHLH
5	wound healing	GO:0042060	9.61	POSTN SPARC TGFB2
6	response to lead ion	GO:0010288	9.57	CDK4 SPARC
7	positive regulation of osteoclast differentiation	GO:0045672	9.56	FOS GNAS
8	chaperone-mediated protein complex assembly	GO:0051131	9.54	CLU HSP90AA1
9	osteoblast development	GO:0002076	9.52	PTHLH SATB2
10	endocardial cushion morphogenesis	GO:0003203	9.51	MDM2 TGFB2
11	obsolete positive regulation of cAMP biosynthetic process	GO:0030819	9.48	GNAS PTHLH
12	skeletal system development	GO:0001501	9.46	GNAS POSTN PTHLH TGFB2
13	atrioventricular valve morphogenesis	GO:0003181	9.4	MDM2 TGFB2
14	response to gravity	GO:0009629	9.32	FOS SPARC
15	positive regulation of tau-protein kinase activity	GO:1902949	9.26	CLU HSP90AA1
16	positive regulation of cell cycle	GO:0045787	9.13	CDK4 MDM2 TGFB2
17	response to drug	GO:0042493	9.1	CDK4 FABP3 FOS GNAS MDM2 TGFB2

Molecular functions related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.53	CDK4 CLU CTSB DACH1 EMILIN1 FABP3
2	tau protein binding	GO:0048156	8.96	CLU HSP90AA1

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Sources for Peripheral Osteosarcoma

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