Peripheral Osteosarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Peripheral Osteosarcoma

MalaCards integrated aliases for Peripheral Osteosarcoma:

Name: Peripheral Osteosarcoma ¹² ¹⁵

Bone Surface Osteosarcoma ⁷³

Surface Osteosarcoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3374

NCIt ⁵⁰ C7134

UMLS ⁷³ C1332591

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Summaries for Peripheral Osteosarcoma

MalaCards based summary : Peripheral Osteosarcoma, also known as bone surface osteosarcoma, is related to ring chromosome 7 and undifferentiated embryonal sarcoma of the liver. An important gene associated with Peripheral Osteosarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Pathways in cancer and WNT Signaling. Affiliated tissues include bone, brain and liver, and related phenotypes are Increased cell death HMECs cells and homeostasis/metabolism

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Related Diseases for Peripheral Osteosarcoma

Diseases related to Peripheral Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)

#	Related Disease	Score	Top Affiliating Genes
1	ring chromosome 7	10.3	CDK4 MDM2
2	undifferentiated embryonal sarcoma of the liver	10.3	CDK4 MDM2
3	infiltrating angiolipoma	10.2	CDK4 MDM2
4	spindle cell lipoma	10.2	CDK4 MDM2
5	extraosseous osteosarcoma	10.2	MDM2 SPARC
6	cellular myxoid liposarcoma	10.2	CDK4 MDM2
7	lipoblastoma	10.2	CDK4 MDM2
8	ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	10.2	GNAS SATB2
9	atypical lipomatous tumor	10.2	CDK4 MDM2
10	mixed liposarcoma	10.2	CDK4 MDM2
11	conventional central osteosarcoma	10.2	MDM2 SATB2 SPARC
12	malignant fibrous histiocytoma of bone	10.2	CDK4 FOS MDM2
13	tooth ankylosis	10.1	PTHLH SPARC
14	lymph node cancer	10.1	FOS PLAUR
15	clear cell chondrosarcoma	10.1	PTHLH SPARC
16	chondroid lipoma	10.1	CDK4 MDM2
17	melorheostosis	10.1	POSTN SPARC
18	multiple enchondromatosis, maffucci type	10.0	GNAS IDH1
19	nervous system cancer	10.0	CDK4 IDH1 MDM2
20	pilocytic astrocytoma of cerebellum	10.0	GNAS IDH1
21	bone osteosarcoma	10.0	CDK4 EMILIN1 MDM2 SATB2 SPARC
22	inflammatory mfh	10.0	CDK4 FRS2 MDM2
23	well-differentiated liposarcoma	10.0	CDK4 FRS2 MDM2
24	chondrosarcoma	9.9	IDH1 PTHLH SPARC
25	brain cancer	9.9	CDK4 IDH1 MDM2 PLAUR
26	prolapse of female genital organ	9.9	SPARC WDFY2
27	periosteal chondrosarcoma	9.9	CDK4 IDH1 MDM2 PTHLH
28	colorectal cancer	9.8
29	aneurysmal bone cysts	9.8
30	myelodysplastic syndrome	9.8
31	osteoporosis	9.8	FOS PTHLH SATB2 SPARC TGFB2
32	large intestine cancer	9.7	CDK4 DACH1 GNAS IDH1 MDM2 PLAUR
33	periosteal osteogenic sarcoma	9.6	CDK4 DACH1 FOS IDH1 MDM2 SATB2
34	juxtacortical osteosarcoma	8.5	CDK4 CLU CTSB EMILIN1 FABP3 FOS

Graphical network of the top 20 diseases related to Peripheral Osteosarcoma:

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Symptoms & Phenotypes for Peripheral Osteosarcoma

GenomeRNAi Phenotypes related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death HMECs cells	GR00103-A-0	9.02	CLU CTSB FABP3 MDM2 PLAUR

MGI Mouse Phenotypes related to Peripheral Osteosarcoma:

⁴⁶ (show all 19)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.39	CDK4 CLU CTSB DACH1 EMILIN1 FABP3
2	cellular	MP:0005384	10.38	CDK4 CTSB DACH1 FABP3 FOS FRS2
3	behavior/neurological	MP:0005386	10.36	CDK4 CLU CTSB DACH1 FABP3 FOS
4	cardiovascular system	MP:0005385	10.35	CDK4 CLU EMILIN1 FABP3 FRS2 GNAS
5	growth/size/body region	MP:0005378	10.35	CDK4 CTSB FOS FRS2 GNAS IDH1
6	immune system	MP:0005387	10.27	CDK4 CLU CTSB FOS GNAS IDH1
7	hematopoietic system	MP:0005397	10.26	CDK4 EMILIN1 FOS GNAS IDH1 MDM2
8	endocrine/exocrine gland	MP:0005379	10.25	CDK4 CTSB DACH1 FOS GNAS MDM2
9	mortality/aging	MP:0010768	10.25	CDK4 CTSB DACH1 FABP3 FOS FRS2
10	craniofacial	MP:0005382	10.21	FOS FRS2 GNAS MDM2 POSTN PTHLH
11	limbs/digits/tail	MP:0005371	10.11	FOS FRS2 GNAS MDM2 POSTN PTHLH
12	nervous system	MP:0003631	10.1	CDK4 CLU CTSB DACH1 FOS FRS2
13	integument	MP:0010771	10.08	CDK4 CTSB EMILIN1 FOS GNAS MDM2
14	muscle	MP:0005369	10.01	CDK4 CLU FABP3 GNAS MDM2 PLAUR
15	neoplasm	MP:0002006	9.97	CDK4 CTSB FOS GNAS MDM2 POSTN
16	renal/urinary system	MP:0005367	9.91	CDK4 CLU CTSB FRS2 GNAS MDM2
17	respiratory system	MP:0005388	9.7	DACH1 GNAS IDH1 PLAUR PTHLH SATB2
18	skeleton	MP:0005390	9.65	FOS FRS2 GNAS IDH1 MDM2 POSTN
19	vision/eye	MP:0005391	9.17	CDK4 FABP3 FOS FRS2 PTHLH SPARC

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Drugs & Therapeutics for Peripheral Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Peripheral Osteosarcoma

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Genetic Tests for Peripheral Osteosarcoma

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Anatomical Context for Peripheral Osteosarcoma

MalaCards organs/tissues related to Peripheral Osteosarcoma:

⁴¹

Bone, Brain, Liver, Lymph Node, Cerebellum

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Publications for Peripheral Osteosarcoma

Articles related to Peripheral Osteosarcoma:

#	Title	Authors	Year
1	Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2-[<sup>18</sup>F]-fluoro-2-deoxy-D-glucose positron emission tomography: A case report. ( 29928362 )		2018
2	Post-traumatic heterotopic ossification of distal tibiofibular syndesmosis mimicking a surface osteosarcoma. ( 24034551 )	Botchu R....Grimer R.	2013
3	High-grade surface osteosarcoma - chondroblastic type. ( 18356791 )		2007
4	Pediatric surface osteosarcoma: clinical, pathologic, and radiologic features. ( 16123997 )	Kaste S.C....Daw N.C.	2006
5	Report of four cases with high-grade surface osteosarcoma. ( 16533804 )		2006
6	High malignant surface osteosarcoma arising at the site of a previously treated aneurysmal bone cyst. ( 8491756 )	Wuisman P...Winkelmann W	1993

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Genes for Peripheral Osteosarcoma

Genes related to Peripheral Osteosarcoma (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MDM2	MDM2 Proto-Oncogene	Protein Coding	16.48	DISEASES inferred ¹⁵
2	CDK4	Cyclin Dependent Kinase 4	Protein Coding	16.18	DISEASES inferred ¹⁵
3	EMILIN1	Elastin Microfibril Interfacer 1	Protein Coding	16.04	DISEASES inferred ¹⁵
4	GNAS	GNAS Complex Locus	Protein Coding	15.08	DISEASES inferred ¹⁵
5	SATB2	SATB Homeobox 2	Protein Coding	14.84	DISEASES inferred ¹⁵
6	DACH1	Dachshund Family Transcription Factor 1	Protein Coding	14.47	DISEASES inferred ¹⁵
7	FABP3	Fatty Acid Binding Protein 3	Protein Coding	13.85	DISEASES inferred ¹⁵
8	SPARC	Secreted Protein Acidic And Cysteine Rich	Protein Coding	13.71	DISEASES inferred ¹⁵
9	POSTN	Periostin	Protein Coding	13.71	DISEASES inferred ¹⁵
10	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	13.7	DISEASES inferred ¹⁵
11	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	13.54	DISEASES inferred ¹⁵
12	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	13.49	DISEASES inferred ¹⁵
13	CTSB	Cathepsin B	Protein Coding	13.33	DISEASES inferred ¹⁵
14	CLU	Clusterin	Protein Coding	13.32	DISEASES inferred ¹⁵
15	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	13.17	DISEASES inferred ¹⁵
16	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic	Protein Coding	13.17	DISEASES inferred ¹⁵
17	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	4.67	DISEASES inferred ¹⁵
18	WDFY2	WD Repeat And FYVE Domain Containing 2	Protein Coding	3.88	DISEASES inferred ¹⁵

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Variations for Peripheral Osteosarcoma

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Expression for Peripheral Osteosarcoma

Search GEO for disease gene expression data for Peripheral Osteosarcoma.

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Pathways for Peripheral Osteosarcoma

Pathways related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁷	12.49	CDK4 FOS GNAS MDM2 TGFB2
2	WNT Signaling ⁶⁴	12.1	CDK4 FOS GNAS PLAUR
3	Proteoglycans in cancer ³⁷	11.86	FRS2 MDM2 PLAUR TGFB2
4	Cell cycle Cell cycle (generic schema) ²² Show member pathways Cell cycle Regulation of G1/S transition (part 2) ²² G0 and Early G1 ⁶⁶ G2 Phase ⁶⁶	11.69	CDK4 FOS GNAS PLAUR
5	Parathyroid hormone synthesis, secretion and action ³⁷	11.63	FOS GNAS PTHLH
6	Human Thyroid Stimulating Hormone (TSH) signaling pathway ¹	11.33	CDK4 FOS GNAS
7	ATF-2 transcription factor network ¹	11.07	CDK4 FOS TGFB2
8	FGF signaling pathway ¹	10.8	FOS FRS2 PLAUR
9	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	10.39	FOS GNAS PTHLH

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GO Terms for Peripheral Osteosarcoma

Cellular components related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.92	CLU CTSB EMILIN1 FABP3 POSTN PTHLH
2	extracellular matrix	GO:0031012	9.71	CLU EMILIN1 POSTN SPARC
3	extracellular region	GO:0005576	9.65	CLU CTSB EMILIN1 GNAS IDH1 PLAUR
4	transcription factor complex	GO:0005667	9.46	CDK4 DACH1 FOS SATB2
5	platelet alpha granule lumen	GO:0031093	9.43	CLU SPARC TGFB2
6	collagen-containing extracellular matrix	GO:0062023	9.1	CLU CTSB EMILIN1 POSTN SPARC TGFB2
7	cytoplasm	GO:0005737	10.18	CDK4 CLU DACH1 FABP3 FOS FRS2

Biological processes related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet degranulation	GO:0002576	9.7	CLU SPARC TGFB2
2	negative regulation of angiogenesis	GO:0016525	9.67	EMILIN1 SPARC TGFB2
3	response to toxic substance	GO:0009636	9.63	CDK4 FOS MDM2
4	female pregnancy	GO:0007565	9.61	FOS GNAS PTHLH
5	wound healing	GO:0042060	9.58	POSTN SPARC TGFB2
6	regulation of gene expression	GO:0010468	9.56	CDK4 MDM2 PTHLH SATB2
7	positive regulation of osteoclast differentiation	GO:0045672	9.55	FOS GNAS
8	response to lead ion	GO:0010288	9.54	CDK4 SPARC
9	osteoblast development	GO:0002076	9.51	PTHLH SATB2
10	endocardial cushion morphogenesis	GO:0003203	9.48	MDM2 TGFB2
11	atrioventricular valve morphogenesis	GO:0003181	9.37	MDM2 TGFB2
12	positive regulation of cell cycle	GO:0045787	9.33	CDK4 MDM2 TGFB2
13	response to gravity	GO:0009629	9.32	FOS SPARC
14	skeletal system development	GO:0001501	9.26	GNAS POSTN PTHLH TGFB2
15	response to drug	GO:0042493	9.1	CDK4 FABP3 FOS GNAS MDM2 TGFB2

Molecular functions related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.53	CDK4 CLU CTSB DACH1 EMILIN1 FABP3

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