MCID: PRP024
MIFTS: 34

Peripheral Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Peripheral Osteosarcoma

MalaCards integrated aliases for Peripheral Osteosarcoma:

Name: Peripheral Osteosarcoma 12 15
Bone Surface Osteosarcoma 73
Surface Osteosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3374
NCIt 50 C7134
UMLS 73 C1332591

Summaries for Peripheral Osteosarcoma

MalaCards based summary : Peripheral Osteosarcoma, also known as bone surface osteosarcoma, is related to ring chromosome 7 and undifferentiated embryonal sarcoma of the liver. An important gene associated with Peripheral Osteosarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Pathways in cancer and WNT Signaling. Affiliated tissues include bone, brain and liver, and related phenotypes are Increased cell death HMECs cells and homeostasis/metabolism

Related Diseases for Peripheral Osteosarcoma

Diseases related to Peripheral Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 ring chromosome 7 10.3 CDK4 MDM2
2 undifferentiated embryonal sarcoma of the liver 10.3 CDK4 MDM2
3 infiltrating angiolipoma 10.2 CDK4 MDM2
4 spindle cell lipoma 10.2 CDK4 MDM2
5 extraosseous osteosarcoma 10.2 MDM2 SPARC
6 cellular myxoid liposarcoma 10.2 CDK4 MDM2
7 lipoblastoma 10.2 CDK4 MDM2
8 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.2 GNAS SATB2
9 atypical lipomatous tumor 10.2 CDK4 MDM2
10 mixed liposarcoma 10.2 CDK4 MDM2
11 conventional central osteosarcoma 10.2 MDM2 SATB2 SPARC
12 malignant fibrous histiocytoma of bone 10.2 CDK4 FOS MDM2
13 tooth ankylosis 10.1 PTHLH SPARC
14 lymph node cancer 10.1 FOS PLAUR
15 clear cell chondrosarcoma 10.1 PTHLH SPARC
16 chondroid lipoma 10.1 CDK4 MDM2
17 melorheostosis 10.1 POSTN SPARC
18 multiple enchondromatosis, maffucci type 10.0 GNAS IDH1
19 nervous system cancer 10.0 CDK4 IDH1 MDM2
20 pilocytic astrocytoma of cerebellum 10.0 GNAS IDH1
21 bone osteosarcoma 10.0 CDK4 EMILIN1 MDM2 SATB2 SPARC
22 inflammatory mfh 10.0 CDK4 FRS2 MDM2
23 well-differentiated liposarcoma 10.0 CDK4 FRS2 MDM2
24 chondrosarcoma 9.9 IDH1 PTHLH SPARC
25 brain cancer 9.9 CDK4 IDH1 MDM2 PLAUR
26 prolapse of female genital organ 9.9 SPARC WDFY2
27 periosteal chondrosarcoma 9.9 CDK4 IDH1 MDM2 PTHLH
28 colorectal cancer 9.8
29 aneurysmal bone cysts 9.8
30 myelodysplastic syndrome 9.8
31 osteoporosis 9.8 FOS PTHLH SATB2 SPARC TGFB2
32 large intestine cancer 9.7 CDK4 DACH1 GNAS IDH1 MDM2 PLAUR
33 periosteal osteogenic sarcoma 9.6 CDK4 DACH1 FOS IDH1 MDM2 SATB2
34 juxtacortical osteosarcoma 8.5 CDK4 CLU CTSB EMILIN1 FABP3 FOS

Graphical network of the top 20 diseases related to Peripheral Osteosarcoma:



Diseases related to Peripheral Osteosarcoma

Symptoms & Phenotypes for Peripheral Osteosarcoma

GenomeRNAi Phenotypes related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.02 CLU CTSB FABP3 MDM2 PLAUR

MGI Mouse Phenotypes related to Peripheral Osteosarcoma:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 CDK4 CLU CTSB DACH1 EMILIN1 FABP3
2 cellular MP:0005384 10.38 CDK4 CTSB DACH1 FABP3 FOS FRS2
3 behavior/neurological MP:0005386 10.36 CDK4 CLU CTSB DACH1 FABP3 FOS
4 cardiovascular system MP:0005385 10.35 CDK4 CLU EMILIN1 FABP3 FRS2 GNAS
5 growth/size/body region MP:0005378 10.35 CDK4 CTSB FOS FRS2 GNAS IDH1
6 immune system MP:0005387 10.27 CDK4 CLU CTSB FOS GNAS IDH1
7 hematopoietic system MP:0005397 10.26 CDK4 EMILIN1 FOS GNAS IDH1 MDM2
8 endocrine/exocrine gland MP:0005379 10.25 CDK4 CTSB DACH1 FOS GNAS MDM2
9 mortality/aging MP:0010768 10.25 CDK4 CTSB DACH1 FABP3 FOS FRS2
10 craniofacial MP:0005382 10.21 FOS FRS2 GNAS MDM2 POSTN PTHLH
11 limbs/digits/tail MP:0005371 10.11 FOS FRS2 GNAS MDM2 POSTN PTHLH
12 nervous system MP:0003631 10.1 CDK4 CLU CTSB DACH1 FOS FRS2
13 integument MP:0010771 10.08 CDK4 CTSB EMILIN1 FOS GNAS MDM2
14 muscle MP:0005369 10.01 CDK4 CLU FABP3 GNAS MDM2 PLAUR
15 neoplasm MP:0002006 9.97 CDK4 CTSB FOS GNAS MDM2 POSTN
16 renal/urinary system MP:0005367 9.91 CDK4 CLU CTSB FRS2 GNAS MDM2
17 respiratory system MP:0005388 9.7 DACH1 GNAS IDH1 PLAUR PTHLH SATB2
18 skeleton MP:0005390 9.65 FOS FRS2 GNAS IDH1 MDM2 POSTN
19 vision/eye MP:0005391 9.17 CDK4 FABP3 FOS FRS2 PTHLH SPARC

Drugs & Therapeutics for Peripheral Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Peripheral Osteosarcoma

Genetic Tests for Peripheral Osteosarcoma

Anatomical Context for Peripheral Osteosarcoma

MalaCards organs/tissues related to Peripheral Osteosarcoma:

41
Bone, Brain, Liver, Lymph Node, Cerebellum

Publications for Peripheral Osteosarcoma

Articles related to Peripheral Osteosarcoma:

# Title Authors Year
1
Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2-[<sup>18</sup>F]-fluoro-2-deoxy-D-glucose positron emission tomography: A case report. ( 29928362 )
2018
2
Post-traumatic heterotopic ossification of distal tibiofibular syndesmosis mimicking a surface osteosarcoma. ( 24034551 )
2013
3
High-grade surface osteosarcoma - chondroblastic type. ( 18356791 )
2007
4
Pediatric surface osteosarcoma: clinical, pathologic, and radiologic features. ( 16123997 )
2006
5
Report of four cases with high-grade surface osteosarcoma. ( 16533804 )
2006
6
High malignant surface osteosarcoma arising at the site of a previously treated aneurysmal bone cyst. ( 8491756 )
1993

Variations for Peripheral Osteosarcoma

Expression for Peripheral Osteosarcoma

Search GEO for disease gene expression data for Peripheral Osteosarcoma.

Pathways for Peripheral Osteosarcoma

GO Terms for Peripheral Osteosarcoma

Cellular components related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 CLU CTSB EMILIN1 FABP3 POSTN PTHLH
2 extracellular matrix GO:0031012 9.71 CLU EMILIN1 POSTN SPARC
3 extracellular region GO:0005576 9.65 CLU CTSB EMILIN1 GNAS IDH1 PLAUR
4 transcription factor complex GO:0005667 9.46 CDK4 DACH1 FOS SATB2
5 platelet alpha granule lumen GO:0031093 9.43 CLU SPARC TGFB2
6 collagen-containing extracellular matrix GO:0062023 9.1 CLU CTSB EMILIN1 POSTN SPARC TGFB2
7 cytoplasm GO:0005737 10.18 CDK4 CLU DACH1 FABP3 FOS FRS2

Biological processes related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.7 CLU SPARC TGFB2
2 negative regulation of angiogenesis GO:0016525 9.67 EMILIN1 SPARC TGFB2
3 response to toxic substance GO:0009636 9.63 CDK4 FOS MDM2
4 female pregnancy GO:0007565 9.61 FOS GNAS PTHLH
5 wound healing GO:0042060 9.58 POSTN SPARC TGFB2
6 regulation of gene expression GO:0010468 9.56 CDK4 MDM2 PTHLH SATB2
7 positive regulation of osteoclast differentiation GO:0045672 9.55 FOS GNAS
8 response to lead ion GO:0010288 9.54 CDK4 SPARC
9 osteoblast development GO:0002076 9.51 PTHLH SATB2
10 endocardial cushion morphogenesis GO:0003203 9.48 MDM2 TGFB2
11 atrioventricular valve morphogenesis GO:0003181 9.37 MDM2 TGFB2
12 positive regulation of cell cycle GO:0045787 9.33 CDK4 MDM2 TGFB2
13 response to gravity GO:0009629 9.32 FOS SPARC
14 skeletal system development GO:0001501 9.26 GNAS POSTN PTHLH TGFB2
15 response to drug GO:0042493 9.1 CDK4 FABP3 FOS GNAS MDM2 TGFB2

Molecular functions related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 CDK4 CLU CTSB DACH1 EMILIN1 FABP3

Sources for Peripheral Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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