MCID: PRP024
MIFTS: 32

Peripheral Osteosarcoma

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Peripheral Osteosarcoma

MalaCards integrated aliases for Peripheral Osteosarcoma:

Name: Peripheral Osteosarcoma 12 15
Bone Surface Osteosarcoma 73
Surface Osteosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3374
NCIt 50 C7134
UMLS 73 C1332591

Summaries for Peripheral Osteosarcoma

MalaCards based summary : Peripheral Osteosarcoma, also known as bone surface osteosarcoma, is related to ring chromosome 7 and undifferentiated embryonal sarcoma of the liver. An important gene associated with Peripheral Osteosarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Endometrial cancer and Development EGFR signaling pathway. Affiliated tissues include bone, and related phenotypes are behavior/neurological and cellular

Related Diseases for Peripheral Osteosarcoma

Graphical network of the top 20 diseases related to Peripheral Osteosarcoma:



Diseases related to Peripheral Osteosarcoma

Symptoms & Phenotypes for Peripheral Osteosarcoma

MGI Mouse Phenotypes related to Peripheral Osteosarcoma:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.39 PLAUR POSTN PTHLH SPARC CDK4 CLU
2 cellular MP:0005384 10.37 CTSB DACH1 FABP3 FOS GNAS HSP90AA1
3 homeostasis/metabolism MP:0005376 10.37 FABP3 FOS GNAS IDH1 MDM2 PLAUR
4 growth/size/body region MP:0005378 10.34 MDM2 PLAUR POSTN PTHLH SATB2 SPARC
5 cardiovascular system MP:0005385 10.31 CDK4 CLU EMILIN1 FABP3 GNAS MDM2
6 immune system MP:0005387 10.29 CDK4 CLU CTSB FOS GNAS HSP90AA1
7 endocrine/exocrine gland MP:0005379 10.28 CDK4 CTSB DACH1 FOS GNAS HSP90AA1
8 hematopoietic system MP:0005397 10.25 CDK4 EMILIN1 FOS GNAS IDH1 MDM2
9 mortality/aging MP:0010768 10.22 DACH1 FABP3 FOS GNAS HSP90AA1 IDH1
10 craniofacial MP:0005382 10.2 FOS GNAS HSP90AA1 MDM2 POSTN PTHLH
11 limbs/digits/tail MP:0005371 10.09 FOS GNAS HSP90AA1 MDM2 POSTN PTHLH
12 integument MP:0010771 10.06 CDK4 CTSB EMILIN1 FOS GNAS MDM2
13 nervous system MP:0003631 10 SATB2 TGFB2 FOS GNAS MDM2 PLAUR
14 muscle MP:0005369 9.97 CDK4 CLU FABP3 GNAS MDM2 PLAUR
15 neoplasm MP:0002006 9.87 SPARC CDK4 CTSB FOS GNAS MDM2
16 renal/urinary system MP:0005367 9.76 CDK4 CLU CTSB GNAS MDM2 PLAUR
17 respiratory system MP:0005388 9.5 DACH1 GNAS IDH1 PLAUR PTHLH SATB2
18 skeleton MP:0005390 9.32 POSTN PTHLH SATB2 SPARC TGFB2 FOS

Drugs & Therapeutics for Peripheral Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Peripheral Osteosarcoma

Genetic Tests for Peripheral Osteosarcoma

Anatomical Context for Peripheral Osteosarcoma

MalaCards organs/tissues related to Peripheral Osteosarcoma:

41
Bone

Publications for Peripheral Osteosarcoma

Articles related to Peripheral Osteosarcoma:

# Title Authors Year
1
Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2-[<sup>18</sup>F]-fluoro-2-deoxy-D-glucose positron emission tomography: A case report. ( 29928362 )
2018
2
Post-traumatic heterotopic ossification of distal tibiofibular syndesmosis mimicking a surface osteosarcoma. ( 24034551 )
2013
3
High-grade surface osteosarcoma - chondroblastic type. ( 18356791 )
2007
4
Pediatric surface osteosarcoma: clinical, pathologic, and radiologic features. ( 16123997 )
2006
5
Report of four cases with high-grade surface osteosarcoma. ( 16533804 )
2006
6
Submicroscopic and immunohistochemical profile of surface osteosarcomas. ( 10503742 )
1999

Variations for Peripheral Osteosarcoma

Expression for Peripheral Osteosarcoma

Search GEO for disease gene expression data for Peripheral Osteosarcoma.

Pathways for Peripheral Osteosarcoma

GO Terms for Peripheral Osteosarcoma

Cellular components related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 CLU CTSB EMILIN1 FABP3 POSTN PTHLH
2 perinuclear region of cytoplasm GO:0048471 9.83 CDK4 CLU CTSB GNAS HSP90AA1
3 ficolin-1-rich granule lumen GO:1904813 9.63 CTSB HSP90AA1 IDH1
4 extracellular matrix GO:0031012 9.62 CLU EMILIN1 POSTN TGFB2
5 endocytic vesicle lumen GO:0071682 9.37 HSP90AA1 SPARC
6 extracellular region GO:0005576 9.36 CLU CTSB EMILIN1 GNAS HSP90AA1 IDH1
7 platelet alpha granule lumen GO:0031093 9.33 CLU SPARC TGFB2
8 transcription factor complex GO:0005667 9.26 CDK4 DACH1 FOS SATB2
9 cytoplasm GO:0005737 10.22 CDK4 CLU DACH1 FABP3 FOS GNAS

Biological processes related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.72 CLU SPARC TGFB2
2 response to toxic substance GO:0009636 9.67 CDK4 FOS MDM2
3 regulation of gene expression GO:0010468 9.67 CDK4 MDM2 PTHLH SATB2
4 female pregnancy GO:0007565 9.63 FOS GNAS PTHLH
5 wound healing GO:0042060 9.61 POSTN SPARC TGFB2
6 response to lead ion GO:0010288 9.57 CDK4 SPARC
7 positive regulation of osteoclast differentiation GO:0045672 9.56 FOS GNAS
8 chaperone-mediated protein complex assembly GO:0051131 9.54 CLU HSP90AA1
9 osteoblast development GO:0002076 9.52 PTHLH SATB2
10 endocardial cushion morphogenesis GO:0003203 9.51 MDM2 TGFB2
11 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.48 GNAS PTHLH
12 skeletal system development GO:0001501 9.46 GNAS POSTN PTHLH TGFB2
13 atrioventricular valve morphogenesis GO:0003181 9.4 MDM2 TGFB2
14 response to gravity GO:0009629 9.32 FOS SPARC
15 positive regulation of tau-protein kinase activity GO:1902949 9.26 CLU HSP90AA1
16 positive regulation of cell cycle GO:0045787 9.13 CDK4 MDM2 TGFB2
17 response to drug GO:0042493 9.1 CDK4 FABP3 FOS GNAS MDM2 TGFB2

Molecular functions related to Peripheral Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 CDK4 CLU CTSB DACH1 EMILIN1 FABP3
2 tau protein binding GO:0048156 8.96 CLU HSP90AA1

Sources for Peripheral Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....