PAD
MCID: PRP027
MIFTS: 71

Peripheral Vascular Disease (PAD)

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Peripheral Vascular Disease

MalaCards integrated aliases for Peripheral Vascular Disease:

Name: Peripheral Vascular Disease 41 38 12 3 15
Peripheral Arterial Disease 41 43 3 63
Arterial Occlusive Disease 41 38 12 15
Peripheral Vascular Diseases 55 44 73
Arterial Occlusive Diseases 55 73
Pad 41 3
Peripheral Occlusive Disease 41
Peripheral Arterial Diseases 73
Helicobacter Infections 73

Classifications:



External Ids:

Disease Ontology 12 DOID:341
ICD9CM 35 443.81
MeSH 44 D016491
SNOMED-CT 68 2929001
ICD10 33 I73.8

Summaries for Peripheral Vascular Disease

MedlinePlus : 43 Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of PAD is atherosclerosis. This happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs. Plaque is a substance made up of fat and cholesterol. It causes the arteries to narrow or become blocked. This can reduce or stop blood flow, usually to the legs. If severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg. The main risk factor for PAD is smoking. Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke. Many people who have PAD don't have any symptoms. If you have symptoms, they may include Pain, numbness, achiness, or heaviness in the leg muscles. This happens when walking or climbing stairs. Weak or absent pulses in the legs or feet Sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all A pale or bluish color to the skin A lower temperature in one leg than the other leg Poor nail growth on the toes and decreased hair growth on the legs Erectile dysfunction, especially among men who have diabetes PAD can increase your risk of heart attack, stroke, and transient ischemic attack. Doctors diagnose PAD with a physical exam and heart and imaging tests. Treatments include lifestyle changes, medicines, and sometimes surgery. Lifestyle changes include dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Peripheral Vascular Disease, also known as peripheral arterial disease, is related to peripheral artery disease and buerger disease, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Peripheral Vascular Disease is ALB (Albumin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. The drugs Testosterone and Testosterone enanthate have been mentioned in the context of this disorder. Affiliated tissues include Bone, endothelial and heart, and related phenotypes are Decreased free cholesterol and cardiovascular system

Disease Ontology : 12 A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.

CDC : 3 Peripheral Arterial Disease (PAD) in the Legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can occur in any blood vessel, but it is more common in the legs than the arms.

PubMed Health : 63 About peripheral arterial disease: Peripheral arterial disease (P.A.D.) is a disease in which plaque (plak) builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.When plaque builds up in the body's arteries, the condition is called atherosclerosis (ATH-er-o-skler-O-sis). Over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.P.A.D. usually affects the arteries in the legs, but it also can affect the arteries that carry blood from your heart to your head, arms, kidneys, and stomach. This article focuses on P.A.D. that affects blood flow to the legs.

Related Diseases for Peripheral Vascular Disease

Diseases related to Peripheral Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 416)
# Related Disease Score Top Affiliating Genes
1 peripheral artery disease 33.6 ACE APOB CRP IL6 SELP VCAM1
2 buerger disease 32.5 F2 SELE SERPINE1
3 grange syndrome 31.8 F3 PLAT SELE SELP THBD VCAM1
4 ischemia 30.7 ACE PLAT SELP VEGFA
5 carotid stenosis 30.3 ACE CRP SELP
6 aortic aneurysm, familial abdominal, 1 30.3 ACE CRP IL6
7 polyarteritis nodosa 30.2 CRP IL6 SELE
8 limb ischemia 30.1 ACE IL6 VEGFA VWF
9 intermittent claudication 30.1 ACE ALB CRP F2 IL6 SELP
10 sleep apnea 30.1 ACE CRP IL6
11 critical limb ischemia 29.9 IL6 SELE VEGFA
12 aortic valve disease 2 29.9 ACE CRP VWF
13 protein s deficiency 29.9 F2 F3 SERPINC1
14 uremia 29.9 ALB CRP VWF
15 heparin-induced thrombocytopenia 29.8 F3 SERPINC1
16 cardiogenic shock 29.8 IL6 PLAT
17 sudden sensorineural hearing loss 29.8 F2 IL6
18 vasculitis 29.8 CRP SELE THBD VCAM1 VWF
19 protein c deficiency 29.8 F2 SERPINC1 THBD
20 tangier disease 29.7 APOA1 APOB LPA
21 diabetes mellitus 29.7 ACE ALB APOA1 APOB CRP IL6
22 chronic venous insufficiency 29.7 PLAT SELP SERPINE1 VCAM1
23 coronary artery anomaly 29.7 ACE APOA1 APOB CRP F2 LPA
24 liver disease 29.7 ALB F2 F3 IL6
25 leptospirosis 29.7 CRP F2 IL6
26 nutritional deficiency disease 29.7 ALB CRP IL6
27 systemic scleroderma 29.6 ACE CRP SELE SELP
28 angina pectoris 29.6 ACE CRP IL6 PLAT SERPINC1 VWF
29 ischemic heart disease 29.5 ACE APOA1 APOB CRP IL6
30 chronic kidney failure 29.5 ACE ALB APOB CRP IL6 LPA
31 hypersplenism 29.5 ALB F2 SERPINC1
32 varicose veins 29.5 F2 SERPINC1 VEGFA VWF
33 kidney disease 29.5 ACE ALB CRP IL6 LPA SERPINE1
34 hemophilia 29.4 F2 F3 VWF
35 hypercholesterolemia, familial 29.4 ACE APOA1 APOB CRP LPA
36 liver cirrhosis 29.4 ALB F2 F3 SERPINC1
37 systolic heart failure 29.4 ACE CRP IL6
38 microvascular complications of diabetes 5 29.4 ACE ALB SERPINE1 VCAM1 VEGFA
39 end stage renal failure 29.4 ACE ALB APOB CRP IL6
40 thrombophlebitis 29.3 F2 PLAT SERPINC1 SERPINE1
41 venous insufficiency 29.3 CRP F2 PLAT SELP SERPINE1 VCAM1
42 inflammatory bowel disease 29.2 ALB CRP IL6 SELE SELP VCAM1
43 arteriosclerosis obliterans 29.2 IL6 SELP VCAM1
44 carotid artery disease 29.2 ACE APOA1 APOB CRP LPA SELE
45 takayasu arteritis 29.1 CRP IL6 SELE THBD VCAM1 VWF
46 retinal artery occlusion 29.0 ACE F2 IL6 SERPINC1 SERPINE1 VEGFA
47 asthma 29.0 F2 IL6 PPBP SELE SELP VCAM1
48 behcet syndrome 29.0 CRP IL6 SELE SERPINC1 THBD
49 body mass index quantitative trait locus 11 29.0 APOA1 APOB CRP IL6 LPA SELE
50 thrombocytosis 29.0 CRP F2 F3 IL6 SELP SERPINC1

Comorbidity relations with Peripheral Vascular Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 98)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Vascular Insufficiency of Intestine Anxiety
Aortic Aneurysm Aortic Atherosclerosis
Aortic Valve Disease 1 Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Renovascular Hypertension Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Buerger Disease Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Chronic Ulcer of Skin
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetes Mellitus, Noninsulin-Dependent
Diabetic Peripheral Angiopathy Diabetic Polyneuropathy
Dressler's Syndrome Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Gas Gangrene
Generalized Atherosclerosis Gout
Heart Disease Hyperlipoproteinemia, Type Iv
Hyperlipoproteinemia, Type V Hypertension, Essential
Hypertensive Encephalopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma

Graphical network of the top 20 diseases related to Peripheral Vascular Disease:



Diseases related to Peripheral Vascular Disease

Symptoms & Phenotypes for Peripheral Vascular Disease

UMLS symptoms related to Peripheral Vascular Disease:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB LPA SELP

MGI Mouse Phenotypes related to Peripheral Vascular Disease:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 ACE APOA1 APOB CRP F2 F3
2 homeostasis/metabolism MP:0005376 10.39 ACE ALB APOA1 APOB CRP F2
3 immune system MP:0005387 10.31 ACE APOB CRP F2 F3 IL6
4 cellular MP:0005384 10.3 ALB APOA1 APOB F3 IL6 PLAT
5 hematopoietic system MP:0005397 10.29 ACE F2 F3 IL6 PLAT SELE
6 growth/size/body region MP:0005378 10.27 ACE APOB F2 F3 IL6 PLAT
7 mortality/aging MP:0010768 10.2 ACE ALB APOB F2 F3 IL6
8 liver/biliary system MP:0005370 10.11 ACE ALB APOA1 APOB IL6 SELE
9 integument MP:0010771 10.1 APOA1 F2 F3 IL6 PLAT SELE
10 digestive/alimentary MP:0005381 10.05 ALB F2 IL6 PLAT THBD VEGFA
11 renal/urinary system MP:0005367 9.86 ACE ALB IL6 SELP SERPINC1 SERPINE1
12 reproductive system MP:0005389 9.81 ACE APOB F2 IL6 PLAT SERPINC1
13 respiratory system MP:0005388 9.61 F2 F3 IL6 PLAT SELE SELP
14 vision/eye MP:0005391 9.23 APOB F3 IL6 PLAT SELE SELP

Drugs & Therapeutics for Peripheral Vascular Disease

PubMedHealth treatment related to Peripheral Vascular Disease: 63

Treatments for peripheral arterial disease (P.A.D.) include lifestyle changes, medicines, and surgery or procedures.The overall goals of treating P.A.D. include reducing symptoms, improving quality of life, and preventing complications. Treatment is based on your signs and symptoms, risk factors, and results from a physical exam and tests.Treatment may slow or stop disease progress and reduce the risk of complications. Without treatment, P.A.D. can cause sores or gangrene (tissue death). In extreme cases, it may be necessary to remove part of the leg or foot (amputation).

Drugs for Peripheral Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 550)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testosterone Approved, Investigational Phase 4 58-22-0 6013
2
Testosterone enanthate Approved Phase 4 315-37-7 9416
3
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
4
Methyltestosterone Approved Phase 4 58-18-4 6010
5
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 113665-84-2, 120202-66-6 60606
6
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
7
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73963-72-1 2754
8
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 33069-62-4 36314
9
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
10
Morphine Approved, Investigational Phase 4 57-27-2 5288826
11
Clonidine Approved Phase 4 4205-90-7 2803
12
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
13
Angiotensin II Approved, Investigational Phase 4,Phase 2,Early Phase 1,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
14
Olmesartan Approved, Investigational Phase 4 144689-63-4, 144689-24-7 158781 130881
15
Nicotinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 98-92-0 936
16
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 79902-63-9 54454
17
Nitric Oxide Approved Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 10102-43-9 145068
18
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 55142-85-3 5472
19
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 745-65-3 149351 5280723
20
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 159351-69-6 6442177
21
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
22
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
23
Nicotine Approved Phase 4,Phase 3,Phase 2,Not Applicable 54-11-5 942 89594
24
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
25
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
26
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-63-0 4510
27
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
28
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 1 37350-58-6, 51384-51-1 4171
29
Pravastatin Approved Phase 4,Phase 3,Phase 1 81093-37-0 54687
30
Allopurinol Approved Phase 4 315-30-0 2094
31
Ramipril Approved Phase 4 87333-19-5 5362129
32
Ezetimibe Approved Phase 4,Phase 3,Not Applicable 163222-33-1 150311
33
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 9005-49-6 772 46507594
34
Menthol Approved Phase 4,Phase 2,Phase 3,Not Applicable 2216-51-5 16666
35
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Not Applicable 1177-87-3
36
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
37
Dalteparin Approved Phase 4,Phase 3,Phase 1,Not Applicable 9005-49-6
38
Defibrotide Approved, Investigational Phase 4 83712-60-1
39
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Not Applicable 6493-05-6 4740
40
Iloprost Approved, Investigational Phase 4,Phase 3,Phase 2 78919-13-8 6443959
41
Thrombin Approved, Investigational Phase 4,Phase 3,Not Applicable
42
Vorapaxar Approved Phase 4,Phase 3 618385-01-6
43
Telmisartan Approved, Investigational Phase 4,Not Applicable 144701-48-4 65999
44
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
45
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 111025-46-8 4829
46
Valsartan Approved, Investigational Phase 4,Phase 2 137862-53-4 60846
47
Eplerenone Approved Phase 4,Phase 3 107724-20-9 443872 150310
48
Spironolactone Approved Phase 4,Phase 3 52-01-7, 1952-01-7 5833
49
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
50
Insulin Glargine Approved Phase 4 160337-95-1

Interventional clinical trials:

(show top 50) (show all 1377)
# Name Status NCT ID Phase Drugs
1 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
2 Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease Unknown status NCT00144937 Phase 4 Stepwise therapy for dyslipidemia, hypertension and diabetes
3 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
4 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
5 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
6 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
7 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
8 Platelets Induced Vasodilation, in Vitro and in Vivo Study Unknown status NCT00152646 Phase 4 placebo, aspirine, clopidogrel
9 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
10 Prevena Vascular Groin Wound Study Unknown status NCT02581904 Phase 4
11 Safety and Efficacy Study of OmniWave Endovascular System to Treat Deep Vein Thrombosis Unknown status NCT00640731 Phase 4
12 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Unknown status NCT02563535 Phase 4
13 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
14 Paclitaxel-eluting Balloon Angioplasty With Provisional Use of Nitinol Stent Versus Systematic Implantation of Paclitaxel-eluting Stent for the Treatment of Femoropopliteal de Novo Lesions Unknown status NCT01969630 Phase 4
15 Walking Estimated Limitation Calculated by History - Study 2 Unknown status NCT01424020 Phase 4
16 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
17 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4 levobupivacaine, clonidine
18 Cilostazol Versus Aspirin for Primary Prevention of Atherosclerotic Events Unknown status NCT00886574 Phase 4 Cilostazol;Aspirin
19 Effect of olmesaRtan on Walking distancE and quaLIty of lifE in Peripheral Artery Disease Patients With Hypertension Treated For Intermittent Claudication (RELIEF) Unknown status NCT02373462 Phase 4 Olmesartan;other anti-hypertensive drug
20 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
21 Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease Completed NCT01041729 Phase 4 Atorvastatin;Standard Medical Treatment
22 Effects of Cilostazol on VEGF and Oxidative Stress Biomarkers in Hemodialysis Patients With Peripheral Vascular Disease Completed NCT00431249 Phase 4 Cilostazol
23 Allopurinol as a Possible Oxygen Sparing Agent During Exercise in Peripheral Arterial Disease Completed NCT01147705 Phase 4 Allopurinol;Placebo
24 Angiotensin Converting Enzyme (ACE) Inhibition and Peripheral Arterial Disease Completed NCT00681226 Phase 4 Ramipril or matching placebo
25 Intermittent Mechanical Compression For Peripheral Arterial Disease Completed NCT00855673 Phase 4 Control
26 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed NCT00687076 Phase 4 Ezetimibe;Niaspan;Statin therapy;Aspirin;Clopidogrel;Placebo Niaspan;Placebo Ezetimibe
27 The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease Completed NCT00168467 Phase 4 Ramipril
28 The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) Completed NCT00189618 Phase 4 Aspirin;Clopidogrel
29 GORE VIABAHN ENDOPROSTHESIS Peripheral Vascular Disease Study Completed NCT00228384 Phase 4
30 Testosterone Replacement in Diabetes With Vascular Disease (Version 2) Completed NCT00355537 Phase 4 Testosterone;0.9% saline
31 The Jetstream G3™ Calcium Study Completed NCT01273623 Phase 4
32 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
33 A Study to Collect Intravascular Ultrasound Images Before and After Treatment With the Jetstream System Completed NCT00911417 Phase 4
34 Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease Completed NCT01026389 Phase 4 Dotarem;Gadovist
35 Angioplasty in Peripheral Arterial Disease and Endothelial Function Completed NCT00660634 Phase 4
36 GORE VIABAHN® Versus Plain Old Balloon Angioplasty (POBA) for Superficial Femoral Artery (SFA) In-Stent Restenosis Completed NCT01108861 Phase 4
37 The Jetstream (JET) Post-market Registry Completed NCT01436435 Phase 4
38 4-EVER : a Trial Investigating the Safety of 4F Endovascular Treatment of Infra-Inguinal Arterial Stenotic Disease Completed NCT01413139 Phase 4
39 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
40 Drug Eluting Balloon in peripherAl inTErvention SFA Completed NCT01556542 Phase 4
41 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
42 Prospective, Non-randomized Multi-center, Controlled Physician-initiated Trial: Rotarex Belgium In-stent Occlusion Completed NCT02212626 Phase 4
43 Physician-Initiated Trial Investigating the BeGraft Peripheral Stent Graft System Completed NCT02211716 Phase 4
44 Physician-Initiated Trial Investigating the Efficacy of Endovascular Treatment of Femoropopliteal Arterial Stenotic Disease With the Biotronik Passeo-18 Lux Drug Releasing Balloon and the Biotronik Pulsar-18 Stent (Comparing With 4EVER Trial Results) Completed NCT02211664 Phase 4
45 Standard Balloon Angioplasty Versus Angioplasty With a Paclitaxel-eluting Balloon for Femoral Artery In-stent Restenosis Completed NCT01305070 Phase 4
46 ASSESS Study: Evaluation of ABSOLUTE™ Stent System for Occluded Arteries Completed NCT00180505 Phase 4
47 DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in Patients With Abdominal or Lower Limb Arterial Diseases Completed NCT00955617 Phase 4
48 Effect of Cilostazol Endothelial Progenitor Cells and Collateral Formation in Peripheral Occlusive Artery Disease (PAOD) Completed NCT01952756 Phase 4 Cilostazol;Dummy Placebo
49 PTA vs. Primary Stenting of SFA Using Self-Expandable Nitinol Stents Completed NCT00715416 Phase 4
50 BeSmooth Study, Investigating the BeSmooth Peripheral Stent System for the Treatment of Iliac Lesions Completed NCT02690051 Phase 4

Search NIH Clinical Center for Peripheral Vascular Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Peripheral Vascular Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Peripheral Vascular Disease:
ACY001, bone marrow-derived hematopoietic stem cells for coronary artery occlusions
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Endothelial progenitor cells for peripheral artery disease
Enriched bone marrow-derived progenitor cells for ischemic diseases
MultiGeneAngio, genetically modified endothelial and smooth muscle cells for vascular disease
MultiStem�, bone marrow-derived cells for peripheral vascular disease
Peripheral blood-derived hematopoietic stem cells for leg gangrene
TGI PVG, adipose-derived stem cell-coated vascular graft for peripheral vascular disease
VASCUGEL�, aortic endothelial cells for vascular injury and disease
Embryonic/Adult Cultured Cells Related to Peripheral Vascular Disease:
Bone marrow-derived CD133+ stem cells
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell PMIDs: 19558779
Peripheral blood-derived endothelial cells PMIDs: 19448678 18388019
Peripheral blood-derived hematopoietic stem cells PMIDs: 18388019
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Peripheral blood-derived endothelial progenitor cells PMIDs: 10725398
Bone marrow-derived progenitor cells
MultiGeneAngio, transduced vein-derived endothelial cells
MultiGeneAngio, transduced vein-derived smooth muscle cells
Genetically modified vein-derived smooth muscle
Genetically modified vein-derived endothelial cells
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 21175285 23307829
Peripheral blood-derived hematopoietic stem cells
Adipose-derived stromal cells PMIDs: 8207032 23350681
Aortic endothelial cells cultured in matrix PMIDs: 7667257
Aortic endothelial cells cultured in matrix (VASCUGEL�) PMIDs: 7667257

Cochrane evidence based reviews: peripheral vascular diseases

Genetic Tests for Peripheral Vascular Disease

Anatomical Context for Peripheral Vascular Disease

MalaCards organs/tissues related to Peripheral Vascular Disease:

41
Endothelial, Heart, Bone, Testes, Kidney, Bone Marrow, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Peripheral Vascular Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Peripheral Vascular Disease

Articles related to Peripheral Vascular Disease:

(show top 50) (show all 1948)
# Title Authors Year
1
A correlative study between diffusion and perfusion MR imaging parameters on peripheral arterial disease data. ( 30121254 )
2019
2
A national study of the prevalence and risk factors associated with peripheral arterial disease from China: The China Hypertension Survey, 2012-2015. ( 30389296 )
2019
3
Human adipose-derived stem cells combined with high mobility group box protein 1 might be a novel therapeutic strategy for the treatment of peripheral arterial disease. ( 30449333 )
2019
4
Utilization and in-hospital outcomes associated with atherectomy in the treatment of peripheral vascular disease: An observational analysis from the National Inpatient Sample. ( 29466936 )
2018
5
Peripheral vascular disease assessment in the lower limb: a review of current and emerging non-invasive diagnostic methods. ( 29751811 )
2018
6
Gender Differences in Peripheral Vascular Disease. ( 29628610 )
2018
7
Peripheral vascular disease risk in diabetic individuals without coronary heart disease. ( 29801688 )
2018
8
Hospital readmissions in diabetic kidney transplant recipients with peripheral vascular disease. ( 29704405 )
2018
9
Peripheral arterial disease is associated with higher mortality in patients with incident acute myocardial infarction. ( 29310994 )
2018
10
Adherence to Prescribed Drugs Among 65-74 Year Old Men Diagnosed with Abdominal Aortic Aneurysm or Peripheral Arterial Disease in a Screening Trial: A VIVA Substudy. ( 30393062 )
2018
11
Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure. ( 30188935 )
2018
12
Amputation-Free Survival in Patients With Diabetes Mellitus and Peripheral Arterial Disease With Heel Ulcer: Open Versus Endovascular Surgery. ( 30466379 )
2018
13
A Study of Prevalence of Peripheral Arterial Disease in Type 2 Diabetes Mellitus Patients in a Teaching Hospital. ( 30477058 )
2018
14
Endothelial Progenitor Cells Biology in Diabetes Mellitus and Peripheral Arterial Disease and their Therapeutic Potential. ( 30413930 )
2018
15
Do Nonalcoholic Fatty Liver Disease and Fetuin-A Play Different Roles in Symptomatic Coronary Artery Disease and Peripheral Arterial Disease? ( 29462898 )
2018
16
Hidradenitis suppurativa is associated with myocardial infarction, but not stroke or peripheral arterial disease of the lower extremities. ( 28914960 )
2018
17
Familial Hypercholesterolemia and Risk of Peripheral Arterial Disease and Chronic Kidney Disease. ( 30085243 )
2018
18
Mitochondrial complex I defect resulting from exercise-induced lower limb ischemia in patients with peripheral arterial disease. ( 29792553 )
2018
19
The significance of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and lymphocyte-monocyte ratio in predicting peripheral arterial disease, peripheral neuropathy, osteomyelitis and amputation in diabetic foot infection. ( 30176260 )
2018
20
Association of pentraxin and high-sensitive C-reactive protein as inflammatory biomarkers in patients with chronic periodontitis and peripheral arterial disease. ( 29769764 )
2018
21
Transverse versus Longitudinal Incisions for Femoral Artery Exposure in Treating Patients with Peripheral Vascular Disease. ( 28890060 )
2018
22
Polymorphous Cutaneous Sarcoidosis Associated with Peripheral Vascular Disease and its Dermatoscopic Findings. ( 30050815 )
2018
23
A Review of Distribution of Atherosclerosis in the Lower Limb Arteries of Patients With Diabetes Mellitus and Peripheral Vascular Disease. ( 30068238 )
2018
24
Evaluating two techniques for potentially increasing radial artery size in a follow-up study involving patients with peripheral vascular disease. ( 30076576 )
2018
25
Interaction Between Visual Acuity and Peripheral Vascular Disease with Balance. ( 30136286 )
2018
26
Outcomes of minor amputations in patients with peripheral vascular disease over a 10-year period at a tertiary care institution. ( 30157719 )
2018
27
Axillary Transcatheter Aortic Valve Replacement in Patients With Peripheral Vascular Disease. ( 30291887 )
2018
28
Are two internal thoracic grafts better than one in patients with peripheral vascular disease? ( 30407209 )
2018
29
Corrigendum to "Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis" [CDTM 3/4 (2017) 230-241]. ( 30426111 )
2018
30
Site and Burden of Lower Limb Atherosclerosis Predicts Long-term Mortality in a Cohort of Patients With Peripheral Arterial Disease. ( 30287208 )
2018
31
Review of Transmetatarsal Amputations in the Management of Peripheral Arterial Disease in an Asian Population. ( 30116413 )
2018
32
Peripheral arterial disease increases the risk of multidrug-resistant bacteria and amputation in diabetic foot infections ( 30119162 )
2018
33
Validation of digital ankle-brachial index as a screening tool in symptomatic patients with peripheral arterial disease. ( 30121220 )
2018
34
Full Band Spectra Analysis of Gait Acceleration Signals for Peripheral Arterial Disease Patients. ( 30131716 )
2018
35
Fruit and vegetables in hypertensive women with asymptomatic peripheral arterial disease. ( 30144882 )
2018
36
Near infrared spectroscopy-guided exercise training for claudication in peripheral arterial disease. ( 30152245 )
2018
37
Trends in management and outcome of patients with non-ST elevation acute coronary syndromes and peripheral arterial disease. ( 30154039 )
2018
38
Prehypertension is associated with peripheral arterial disease and low ankle-brachial index. ( 30170644 )
2018
39
Hybrid atherectomy for lower extremity peripheral arterial disease. ( 30193549 )
2018
40
Agreement of clinical tests for the diagnosis of peripheral arterial disease. ( 30201222 )
2018
41
Alterations in heart rate variability in patients with peripheral arterial disease requiring surgical revascularization have limited association with postoperative major adverse cardiovascular and cerebrovascular events. ( 30212552 )
2018
42
Comparison of Outcomes and Cost of Endovascular Management Versus Surgical Bypass for the Management of Lower Extremities Peripheral Arterial Disease. ( 30217372 )
2018
43
Letter to the Editor: "Association of Vitamin D Deficiency With Peripheral Arterial Disease: A Meta-Analysis of Literature Studies". ( 30219903 )
2018
44
Physical activity in premenopausal women with asymptomatic peripheral arterial disease. ( 30222666 )
2018
45
Innovative Multi-Site Photoplethysmography Analysis for Quantifying Pulse Amplitude and Timing Variability Characteristics in Peripheral Arterial Disease. ( 30227612 )
2018
46
Interleukin-22 receptor 1 upregulation and activation in hypoxic endothelial cells improves perfusion recovery in experimental peripheral arterial disease. ( 30236983 )
2018
47
Substitution of poultry and red meat with fish and the risk of peripheral arterial disease: a Danish cohort study. ( 30238314 )
2018
48
Guiding peripheral arterial disease management with magnetic resonance imaging. ( 30251924 )
2018
49
Marine n-3 Fatty Acids and the Risk of Peripheral Arterial Disease. ( 30261957 )
2018
50
A novel patent hemostasis protocol - Prevention of pseudoaneurysm after tibiopedal arterial access for evaluation and treatment of peripheral arterial disease. ( 30262239 )
2018

Variations for Peripheral Vascular Disease

Expression for Peripheral Vascular Disease

Search GEO for disease gene expression data for Peripheral Vascular Disease.

Pathways for Peripheral Vascular Disease

Pathways related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.55 ALB APOA1 APOB F2 F3 PLAT
2
Show member pathways
12.15 APOB F2 SELE SELP THBD
3
Show member pathways
12.09 ALB APOA1 APOB CRP F2 IL6
4
Show member pathways
12.07 F2 F3 PLAT SERPINC1 SERPINE1 THBD
5 12 PLAT SELE THBD VCAM1 VEGFA
6 11.94 ALB IL6 VCAM1 VEGFA
7 11.94 F2 F3 PLAT SERPINC1 SERPINE1 THBD
8 11.72 IL6 SERPINE1 VEGFA
9
Show member pathways
11.58 IL6 SELE VCAM1 VEGFA
10 11.5 F3 IL6 SELE SERPINE1 THBD VCAM1
11 11.45 APOB IL6 LPA PLAT SELP
12 11.42 IL6 SELE SELP VCAM1
13 11.34 ALB APOA1 F2
14 11.25 APOA1 IL6 SELE VCAM1
15 10.65 PLAT SERPINE1

GO Terms for Peripheral Vascular Disease

Cellular components related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.91 APOA1 F3 PLAT THBD VCAM1 VEGFA
2 extracellular region GO:0005576 9.83 ACE ALB APOA1 APOB CRP F2
3 endoplasmic reticulum lumen GO:0005788 9.8 ALB APOA1 APOB F2 IL6 SERPINC1
4 collagen-containing extracellular matrix GO:0062023 9.73 APOA1 F3 PLAT SERPINC1 SERPINE1 VWF
5 blood microparticle GO:0072562 9.71 ALB APOA1 F2 SERPINC1
6 platelet alpha granule lumen GO:0031093 9.55 ALB PPBP SERPINE1 VEGFA VWF
7 extracellular space GO:0005615 9.55 ACE ALB APOA1 APOB CRP F2
8 low-density lipoprotein particle GO:0034362 9.49 APOA1 APOB
9 chylomicron GO:0042627 9.48 APOA1 APOB
10 intermediate-density lipoprotein particle GO:0034363 9.46 APOA1 APOB
11 extracellular exosome GO:0070062 10.07 ACE ALB APOA1 APOB F2 PLAT

Biological processes related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.96 F2 IL6 PPBP SERPINE1 VEGFA
2 cytokine-mediated signaling pathway GO:0019221 9.94 F3 IL6 VCAM1 VEGFA
3 inflammatory response GO:0006954 9.93 CRP IL6 PPBP SELE SELP
4 post-translational protein modification GO:0043687 9.91 ALB APOA1 APOB IL6 SERPINC1
5 defense response to Gram-negative bacterium GO:0050829 9.79 IL6 SELP SERPINE1
6 response to nutrient GO:0007584 9.78 APOA1 SERPINC1 VCAM1
7 response to lipopolysaccharide GO:0032496 9.77 APOB SELE SELP THBD VCAM1
8 cellular protein metabolic process GO:0044267 9.73 ALB APOA1 APOB F2 IL6 SERPINC1
9 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.7 SELE SELP VCAM1
10 negative regulation of blood coagulation GO:0030195 9.65 SERPINE1 THBD
11 acute-phase response GO:0006953 9.65 CRP F2 IL6
12 low-density lipoprotein particle remodeling GO:0034374 9.64 APOB LPA
13 positive regulation of blood coagulation GO:0030194 9.63 F2 SERPINE1
14 positive regulation of leukocyte migration GO:0002687 9.63 SELP VEGFA
15 leukocyte cell-cell adhesion GO:0007159 9.63 SELE SELP VCAM1
16 blood coagulation GO:0007596 9.63 F2 F3 PLAT SERPINC1 THBD VWF
17 regulation of blood coagulation GO:0030193 9.62 F2 SERPINC1
18 positive regulation of positive chemotaxis GO:0050927 9.62 F3 VEGFA
19 fibrinolysis GO:0042730 9.61 F2 PLAT SERPINE1
20 chylomicron assembly GO:0034378 9.6 APOA1 APOB
21 negative regulation of lipid storage GO:0010888 9.59 CRP IL6
22 negative regulation of platelet activation GO:0010544 9.58 F2 THBD
23 chylomicron remodeling GO:0034371 9.58 APOA1 APOB
24 leukocyte tethering or rolling GO:0050901 9.58 SELE SELP VCAM1