MCID: PRP027
MIFTS: 70

Peripheral Vascular Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Peripheral Vascular Disease

MalaCards integrated aliases for Peripheral Vascular Disease:

Name: Peripheral Vascular Disease 41 38 12 3 15
Peripheral Arterial Disease 41 43 3 63
Arterial Occlusive Diseases 55 44 73
Arterial Occlusive Disease 41 38 12
Peripheral Vascular Diseases 55 73
Helicobacter Infections 44 73
Pad 41 3
Peripheral Occlusive Disease 41
Peripheral Arterial Diseases 73

Classifications:



External Ids:

Disease Ontology 12 DOID:341
ICD9CM 35 443.81
SNOMED-CT 68 195624006 2929001
ICD10 33 I73.8

Summaries for Peripheral Vascular Disease

MedlinePlus : 43 Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of PAD is atherosclerosis. This happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs. Plaque is a substance made up of fat and cholesterol. It causes the arteries to narrow or become blocked. This can reduce or stop blood flow, usually to the legs. If severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg. The main risk factor for PAD is smoking. Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke. Many people who have PAD don't have any symptoms. If you have symptoms, they may include Pain, numbness, achiness, or heaviness in the leg muscles. This happens when walking or climbing stairs. Weak or absent pulses in the legs or feet Sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all A pale or bluish color to the skin A lower temperature in one leg than the other leg Poor nail growth on the toes and decreased hair growth on the legs Erectile dysfunction, especially among men who have diabetes PAD can increase your risk of heart attack, stroke, and transient ischemic attack. Doctors diagnose PAD with a physical exam and heart and imaging tests. Treatments include lifestyle changes, medicines, and sometimes surgery. Lifestyle changes include dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Peripheral Vascular Disease, also known as peripheral arterial disease, is related to peripheral artery disease and buerger disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Peripheral Vascular Disease is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include Bone, heart and bone, and related phenotypes are Decreased free cholesterol and cardiovascular system

CDC : 3 Peripheral Arterial Disease (PAD) in the Legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can occur in any blood vessel, but it is more common in the legs than the arms.

Disease Ontology : 12 A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.

PubMed Health : 63 About peripheral arterial disease: Peripheral arterial disease (P.A.D.) is a disease in which plaque (plak) builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.When plaque builds up in the body's arteries, the condition is called atherosclerosis (ATH-er-o-skler-O-sis). Over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.P.A.D. usually affects the arteries in the legs, but it also can affect the arteries that carry blood from your heart to your head, arms, kidneys, and stomach. This article focuses on P.A.D. that affects blood flow to the legs.

Related Diseases for Peripheral Vascular Disease

Diseases related to Peripheral Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
# Related Disease Score Top Affiliating Genes
1 peripheral artery disease 32.3 ACE APOB CRP IL6 SELP VCAM1
2 buerger disease 32.3 F2 SELE SERPINE1
3 ischemia 30.8 ACE PLAT SELP VEGFA
4 carotid stenosis 30.7 ACE CRP SELP
5 polyarteritis nodosa 30.1 CRP IL6 SELE
6 limb ischemia 30.0 ACE IL6 VEGFA VWF
7 vasculitis 29.9 CRP SELE THBD VCAM1 VWF
8 critical limb ischemia 29.7 IL6 SELE VEGFA VWF
9 arteriosclerosis obliterans 29.6 IL6 SELP VCAM1
10 chronic venous insufficiency 29.5 PLAT SELP SERPINE1 VCAM1
11 cytomegalovirus infection 29.5 IL6 SELE VCAM1
12 hypersplenism 29.4 ALB F2 SERPINC1
13 end stage renal failure 29.3 ACE ALB CRP IL6
14 chronic kidney failure 29.3 ACE ALB CRP IL6 VCAM1
15 peritonitis 29.2 ALB CRP F2 IL6
16 hypercholesterolemia, familial 29.2 APOA1 APOB CRP LPA
17 coronary heart disease 1 28.6 ACE APOA1 APOB CRP LPA SERPINE1
18 carotid artery disease 28.2 ACE APOA1 APOB CRP LPA SELE
19 atrial fibrillation 27.9 ACE F2 PLAT PPBP SELP VWF
20 venous insufficiency 27.8 CRP F2 PLAT SELP SERPINE1 VCAM1
21 ischemic heart disease 27.8 ACE APOA1 APOB CRP F2 IL6
22 antiphospholipid syndrome 27.6 F2 F3 PLAT SELE SELP SERPINC1
23 systemic lupus erythematosus 27.6 ALB CRP F3 IL6 SELE THBD
24 angina pectoris 27.5 ACE CRP F3 IL6 SERPINC1 SERPINE1
25 thrombophilia due to thrombin defect 27.2 F2 F3 PLAT SERPINC1 SERPINE1 THBD
26 intermittent claudication 27.2 ACE ALB CRP F2 IL6 SELP
27 thrombosis 27.0 F2 F3 PLAT SELP SERPINC1 SERPINE1
28 diabetes mellitus 27.0 ACE ALB APOA1 APOB CRP IL6
29 acute myocardial infarction 26.8 ACE APOA1 CRP F3 PLAT SELP
30 heart disease 26.0 ACE ALB APOA1 APOB CRP F2
31 thrombophilia 25.7 F2 F3 PLAT PPBP SERPINC1 SERPINE1
32 arteriosclerosis 24.5 ACE APOA1 APOB CRP F3 IL6
33 coronary artery anomaly 23.1 ACE APOA1 APOB CRP F3 IL6
34 arteries, anomalies of 22.5 ACE ALB APOA1 APOB CRP F2
35 vascular disease 21.7 ACE ALB APOA1 APOB CRP F2
36 myocardial infarction 21.1 ACE ALB APOA1 APOB CRP F2
37 peripheral arterial occlusive disease 1 12.4
38 grange syndrome 11.4
39 unilateral absence of a pulmonary artery 10.9 THBD VWF
40 generalized atherosclerosis 10.8 ACE CRP SELP
41 priapism 10.8
42 hypertensive nephropathy 10.8 ACE ALB VEGFA
43 eisenmenger syndrome 10.7 PLAT THBD VWF
44 infiltrating angiolipoma 10.7 VEGFA VWF
45 mercury poisoning 10.7 PLAT THBD
46 severe nonproliferative diabetic retinopathy 10.7 ALB VEGFA
47 hepatopulmonary syndrome 10.7 ALB VEGFA VWF
48 interstitial nephritis 10.7 ACE ALB CRP
49 leukostasis 10.6 SELE VCAM1 VEGFA
50 diabetic angiopathy 10.6 SELE THBD VWF

Comorbidity relations with Peripheral Vascular Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 98)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Vascular Insufficiency of Intestine Anxiety
Aortic Aneurysm Aortic Atherosclerosis
Aortic Valve Disease 1 Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Renovascular Hypertension Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Buerger Disease Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Chronic Ulcer of Skin
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetes Mellitus, Noninsulin-Dependent
Diabetic Peripheral Angiopathy Diabetic Polyneuropathy
Dressler's Syndrome Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Gas Gangrene
Generalized Atherosclerosis Gout
Heart Disease Hyperlipoproteinemia, Type Iv
Hyperlipoproteinemia, Type V Hypertension, Essential
Hypertensive Encephalopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma

Graphical network of the top 20 diseases related to Peripheral Vascular Disease:



Diseases related to Peripheral Vascular Disease

Symptoms & Phenotypes for Peripheral Vascular Disease

UMLS symptoms related to Peripheral Vascular Disease:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB LPA SELP

MGI Mouse Phenotypes related to Peripheral Vascular Disease:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 APOB IL6 ACE CRP F2 F3
2 homeostasis/metabolism MP:0005376 10.39 APOB IL6 ACE CRP F2 ALB
3 immune system MP:0005387 10.31 APOB IL6 ACE CRP F2 F3
4 cellular MP:0005384 10.3 APOA1 F3 APOB ALB VCAM1 VEGFA
5 hematopoietic system MP:0005397 10.29 ACE F2 F3 VCAM1 SERPINE1 VEGFA
6 growth/size/body region MP:0005378 10.27 F3 APOB ACE F2 VCAM1 SERPINE1
7 mortality/aging MP:0010768 10.2 APOB ACE F2 ALB F3 VCAM1
8 liver/biliary system MP:0005370 10.11 APOB IL6 ACE ALB APOA1 SERPINE1
9 integument MP:0010771 10.1 F2 APOA1 F3 SERPINE1 VEGFA THBD
10 digestive/alimentary MP:0005381 10.05 F2 ALB VEGFA THBD VWF IL6
11 renal/urinary system MP:0005367 9.86 ACE ALB SERPINE1 VEGFA THBD SERPINC1
12 reproductive system MP:0005389 9.81 APOB ACE F2 VCAM1 VEGFA THBD
13 respiratory system MP:0005388 9.61 F3 F2 SERPINE1 VEGFA THBD SELE
14 vision/eye MP:0005391 9.23 F3 APOB VEGFA SERPINC1 SELE IL6

Drugs & Therapeutics for Peripheral Vascular Disease

PubMedHealth treatment related to Peripheral Vascular Disease: 63

Treatments for peripheral arterial disease (P.A.D.) include lifestyle changes, medicines, and surgery or procedures.The overall goals of treating P.A.D. include reducing symptoms, improving quality of life, and preventing complications. Treatment is based on your signs and symptoms, risk factors, and results from a physical exam and tests.Treatment may slow or stop disease progress and reduce the risk of complications. Without treatment, P.A.D. can cause sores or gangrene (tissue death). In extreme cases, it may be necessary to remove part of the leg or foot (amputation).

Drugs for Peripheral Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 529)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4 58-22-0 6013
3
Testosterone enanthate Approved Phase 4 315-37-7 9416
4
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
5
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
6
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 120202-66-6, 113665-84-2 60606
7
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73963-72-1 2754
8
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 33069-62-4 36314
9
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
10
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
11
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
12
Clonidine Approved Phase 4 4205-90-7 2803
13
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
14
Morphine Approved, Investigational Phase 4 57-27-2 5288826
15
Angiotensin II Approved, Investigational Phase 4,Phase 2,Early Phase 1,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
16
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
17
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 79902-63-9 54454
18
Nitric Oxide Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 10102-43-9 145068 160954
19
Menthol Approved Phase 4,Phase 2,Phase 3,Not Applicable 2216-51-5 16666
20
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 745-65-3 149351 5280723
21
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 159351-69-6 6442177
22
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
23
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53123-88-9 5284616 6436030 46835353
24
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
25
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 137-58-6 3676
26
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-63-0 4510
27
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 1 37350-58-6, 51384-51-1 4171
28
Pravastatin Approved Phase 4,Phase 3,Phase 1 81093-37-0 54687
29
Allopurinol Approved Phase 4 315-30-0 2094
30
Ramipril Approved Phase 4 87333-19-5 5362129
31
Ezetimibe Approved Phase 4,Phase 3,Not Applicable 163222-33-1 150311
32
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 55142-85-3 5472
33
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 9005-49-6 772 46507594
34
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
35
Dalteparin Approved Phase 4,Phase 3,Phase 1,Not Applicable 9005-49-6
36 Defibrotide Approved, Investigational Phase 4 83712-60-1
37
Iloprost Approved, Investigational Phase 4,Phase 3,Phase 2 78919-13-8 6443959
38
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Not Applicable 6493-05-6 4740
39
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
40
Telmisartan Approved, Investigational Phase 4,Not Applicable 144701-48-4 65999
41
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 111025-46-8 4829
42
Valsartan Approved, Investigational Phase 4,Phase 2 137862-53-4 60846
43
Eplerenone Approved Phase 4,Phase 3 107724-20-9 150310 443872
44
Spironolactone Approved Phase 4,Phase 3 1952-01-7, 52-01-7 5833
45
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
46
Insulin Glargine Approved Phase 4 160337-95-1
47
Insulin Lispro Approved Phase 4 133107-64-9
48
Zinc Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 7440-66-6 23994
49
Insulin Aspart Approved Phase 4 116094-23-6 16132418
50
Insulin Detemir Approved Phase 4 169148-63-4 5311023

Interventional clinical trials:

(show top 50) (show all 1340)
# Name Status NCT ID Phase Drugs
1 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
2 Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease Unknown status NCT00144937 Phase 4 Stepwise therapy for dyslipidemia, hypertension and diabetes
3 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
4 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
5 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
6 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
7 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
8 Platelets Induced Vasodilation, in Vitro and in Vivo Study Unknown status NCT00152646 Phase 4 placebo, aspirine, clopidogrel
9 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
10 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Unknown status NCT01901224 Phase 4 Metformin 1000 mg;Placebo
11 Prevena Vascular Groin Wound Study Unknown status NCT02581904 Phase 4
12 Safety and Efficacy Study of OmniWave Endovascular System to Treat Deep Vein Thrombosis Unknown status NCT00640731 Phase 4
13 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
14 Paclitaxel-eluting Balloon Angioplasty With Provisional Use of Nitinol Stent Versus Systematic Implantation of Paclitaxel-eluting Stent for the Treatment of Femoropopliteal de Novo Lesions Unknown status NCT01969630 Phase 4
15 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
16 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4 levobupivacaine, clonidine
17 Cilostazol Versus Aspirin for Primary Prevention of Atherosclerotic Events Unknown status NCT00886574 Phase 4 Cilostazol;Aspirin
18 Effect of olmesaRtan on Walking distancE and quaLIty of lifE in Peripheral Artery Disease Patients With Hypertension Treated For Intermittent Claudication (RELIEF) Unknown status NCT02373462 Phase 4 Olmesartan;other anti-hypertensive drug
19 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
20 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
21 Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease Completed NCT01041729 Phase 4 Atorvastatin;Standard Medical Treatment
22 Effects of Cilostazol on VEGF and Oxidative Stress Biomarkers in Hemodialysis Patients With Peripheral Vascular Disease Completed NCT00431249 Phase 4 Cilostazol
23 Allopurinol as a Possible Oxygen Sparing Agent During Exercise in Peripheral Arterial Disease Completed NCT01147705 Phase 4 Allopurinol;Placebo
24 Angiotensin Converting Enzyme (ACE) Inhibition and Peripheral Arterial Disease Completed NCT00681226 Phase 4 Ramipril or matching placebo
25 Intermittent Mechanical Compression For Peripheral Arterial Disease Completed NCT00855673 Phase 4 Control
26 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed NCT00687076 Phase 4 Ezetimibe;Niaspan;Statin therapy;Aspirin;Clopidogrel;Placebo Niaspan;Placebo Ezetimibe
27 The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease Completed NCT00168467 Phase 4 Ramipril
28 The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) Completed NCT00189618 Phase 4 Aspirin;Clopidogrel
29 GORE VIABAHN ENDOPROSTHESIS Peripheral Vascular Disease Study Completed NCT00228384 Phase 4
30 Testosterone Replacement in Diabetes With Vascular Disease (Version 2) Completed NCT00355537 Phase 4 Testosterone;0.9% saline
31 The Jetstream G3™ Calcium Study Completed NCT01273623 Phase 4
32 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
33 A Study to Collect Intravascular Ultrasound Images Before and After Treatment With the Jetstream System Completed NCT00911417 Phase 4
34 Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease Completed NCT01026389 Phase 4 Dotarem;Gadovist
35 Angioplasty in Peripheral Arterial Disease and Endothelial Function Completed NCT00660634 Phase 4
36 GORE VIABAHN® Versus Plain Old Balloon Angioplasty (POBA) for Superficial Femoral Artery (SFA) In-Stent Restenosis Completed NCT01108861 Phase 4
37 The Jetstream (JET) Post-market Registry Completed NCT01436435 Phase 4
38 4-EVER : a Trial Investigating the Safety of 4F Endovascular Treatment of Infra-Inguinal Arterial Stenotic Disease Completed NCT01413139 Phase 4
39 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
40 Drug Eluting Balloon in peripherAl inTErvention SFA Completed NCT01556542 Phase 4
41 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
42 Prospective, Non-randomized Multi-center, Controlled Physician-initiated Trial: Rotarex Belgium In-stent Occlusion Completed NCT02212626 Phase 4
43 Physician-Initiated Trial Investigating the BeGraft Peripheral Stent Graft System Completed NCT02211716 Phase 4
44 Standard Balloon Angioplasty Versus Angioplasty With a Paclitaxel-eluting Balloon for Femoral Artery In-stent Restenosis Completed NCT01305070 Phase 4
45 ASSESS Study: Evaluation of ABSOLUTE™ Stent System for Occluded Arteries Completed NCT00180505 Phase 4
46 DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in Patients With Abdominal or Lower Limb Arterial Diseases Completed NCT00955617 Phase 4
47 Effect of Cilostazol Endothelial Progenitor Cells and Collateral Formation in Peripheral Occlusive Artery Disease (PAOD) Completed NCT01952756 Phase 4 Cilostazol;Dummy Placebo
48 PTA vs. Primary Stenting of SFA Using Self-Expandable Nitinol Stents Completed NCT00715416 Phase 4
49 BeSmooth Study, Investigating the BeSmooth Peripheral Stent System for the Treatment of Iliac Lesions Completed NCT02690051 Phase 4
50 EverFlex™ Self-expanding Peripheral Stent With Entrust™ Delivery System Clinical Study Completed NCT02066740 Phase 4

Search NIH Clinical Center for Peripheral Vascular Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Peripheral Vascular Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Peripheral Vascular Disease:
ACY001, bone marrow-derived hematopoietic stem cells for coronary artery occlusions
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Endothelial progenitor cells for peripheral artery disease
Enriched bone marrow-derived progenitor cells for ischemic diseases
MultiGeneAngio, genetically modified endothelial and smooth muscle cells for vascular disease
MultiStem
Peripheral blood-derived hematopoietic stem cells for leg gangrene
TGI PVG, adipose-derived stem cell-coated vascular graft for peripheral vascular disease
VASCUGEL
Embryonic/Adult Cultured Cells Related to Peripheral Vascular Disease:
Bone marrow-derived CD133+ stem cells
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell PMIDs: 19558779
Peripheral blood-derived endothelial cells PMIDs: 19448678 18388019
Peripheral blood-derived hematopoietic stem cells PMIDs: 18388019
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Peripheral blood-derived endothelial progenitor cells PMIDs: 10725398
Bone marrow-derived progenitor cells
MultiGeneAngio, transduced vein-derived endothelial cells
MultiGeneAngio, transduced vein-derived smooth muscle cells
Genetically modified vein-derived smooth muscle
Genetically modified vein-derived endothelial cells
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 21175285 23307829
Peripheral blood-derived hematopoietic stem cells
Adipose-derived stromal cells PMIDs: 8207032 23350681
Aortic endothelial cells cultured in matrix PMIDs: 7667257
Aortic endothelial cells cultured in matrix (VASCUGEL PMIDs: 7667257

Cochrane evidence based reviews: arterial occlusive diseases

Genetic Tests for Peripheral Vascular Disease

Anatomical Context for Peripheral Vascular Disease

MalaCards organs/tissues related to Peripheral Vascular Disease:

41
Heart, Bone, Endothelial, Bone Marrow, Testes, Kidney, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Peripheral Vascular Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Peripheral Vascular Disease

Articles related to Peripheral Vascular Disease:

(show top 50) (show all 602)
# Title Authors Year
1
Utilization and in-hospital outcomes associated with atherectomy in the treatment of peripheral vascular disease: An observational analysis from the National Inpatient Sample. ( 29466936 )
2018
2
Peripheral vascular disease assessment in the lower limb: a review of current and emerging non-invasive diagnostic methods. ( 29751811 )
2018
3
Gender Differences in Peripheral Vascular Disease. ( 29628610 )
2018
4
Peripheral vascular disease risk in diabetic individuals without coronary heart disease. ( 29801688 )
2018
5
Hospital readmissions in diabetic kidney transplant recipients with peripheral vascular disease. ( 29704405 )
2018
6
Efficacy and safety of aspirin in patients with peripheral vascular disease: An updated systematic review and meta-analysis of randomized controlled trials. ( 28403216 )
2017
7
Reply to Letter to Editor regarding the article, "Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia". ( 28397743 )
2017
8
Non-reconstructable peripheral vascular disease of the lower extremity in ten patients treated with adipose-derived stromal vascular fraction cells. ( 27984756 )
2017
9
Evaluation of hyperspectral imaging technology in patients with peripheral vascular disease. ( 28545710 )
2017
10
Wearable Sensor Technology Efficacy in Peripheral Vascular Disease (wSTEP): A Randomized Controlled Trial. ( 28498233 )
2017
11
Serum Interleukin-23 in Polish Patients with Systemic Lupus Erythematosus: Association with Lupus Nephritis, Obesity, and Peripheral Vascular Disease. ( 29430084 )
2017
12
Prevalence of Subclinical Peripheral Vascular Disease in Obese Egyptian Patients. ( 29142342 )
2017
13
Marrow-isolated adult multilineage inducible cells embedded within a biologically-inspired construct promote recovery in a mouse model of peripheral vascular disease. ( 28211362 )
2017
14
Peripheral Vascular Disease: The Beneficial Effect of Exercise in Peripheral Vascular Diseases Based on Clinical Trials. ( 29098622 )
2017
15
Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis. ( 29354806 )
2017
16
Osseointegrated Transtibial Implants in Patients with Peripheral Vascular Disease: A Multicenter Case Series of 5 Patients with 1-Year Follow-up. ( 28926380 )
2017
17
The Role of the Profundoplasty in the Modern Management of Patient with Peripheral Vascular Disease. ( 28549963 )
2017
18
Diabetes mellitus is a coronary heart disease risk equivalent for peripheral vascular disease. ( 28224925 )
2017
19
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 27853042 )
2017
20
Peripheral Vascular Disease: Treatment in Older Adults. ( 28145673 )
2017
21
Social, demographic and clinical characteristics of patients suffering from peripheral vascular disease treated surgically compared to patients treated with endovascular angioplasty. ( 28905042 )
2017
22
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 28397742 )
2017
23
Allopurinol and peripheral vascular disease: enough observational data to warrant interventional studies: Allopurinol and the prevention of vascular disease. ( 28968915 )
2017
24
Peripheral Vascular Disease and Death in Southern European Kidney Transplant Candidates: A Competing Risk Modeling Approach: Erratum. ( 28738405 )
2017
25
Peripheral Vascular Disease in Patients with Diabetic Foot Ulcers - An Emerging Trend: A Prospective Study from North India. ( 28598042 )
2017
26
Use of p53-Silenced Endothelial Progenitor Cells to Treat Ischemia in Diabetic Peripheral Vascular Disease. ( 28365567 )
2017
27
Insidious incrementalism: The silent failure of the microcirculation with increasing peripheral vascular disease risk. ( 28236373 )
2017
28
Transverse versus Longitudinal Incisions for Femoral Artery Exposure in Treating Patients with Peripheral Vascular Disease. ( 28890060 )
2017
29
The Discovery of Novel Genomic, Transcriptomic, and Proteomic Biomarkers in Cardiovascular and Peripheral Vascular Disease: The State of the Art. ( 27298828 )
2016
30
Ventricular Tachycardia: Inferior Vena Cava Filter in a Case of Peripheral Vascular Disease. ( 26794288 )
2016
31
Utility of Indocyanine Green Angiography in Arterial Selection during Free Flap Harvest in Patients with Severe Peripheral Vascular Disease. ( 27826489 )
2016
32
Peripheral vascular disease in diabetic foot- A new trend. ( 27727607 )
2016
33
Transcatheter Aortic Valve Implantation in Patients With Arterial Peripheral Vascular Disease. ( 27884643 )
2016
34
Neutrophil lymphocyte ratio in peripheral vascular disease: a review. ( 26967241 )
2016
35
Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation. ( 26702145 )
2016
36
Evaluation of a novel 2D perfusion angiography technique independent of pump injections for assessment of interventional treatment of peripheral vascular disease. ( 27785678 )
2016
37
An Experimental Model of Peripheral Vascular Disease Involving the Intravenous Injection of Oral Bacteria. ( 28018496 )
2016
38
Treatment of a High-Risk Diabetic Patient with Peripheral Vascular Disease and Osteomyelitis. ( 27423990 )
2016
39
Anesthesia for Patients with Peripheral Vascular Disease and Cardiac Dysfunction. ( 27816134 )
2016
40
SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease. ( 27517840 )
2016
41
Association between Bacterial Infection and Peripheral Vascular Disease: A Review. ( 26900306 )
2016
42
Mortality After Nontraumatic Major Amputation Among Patients WithA Diabetes and Peripheral Vascular Disease: A Systematic Review. ( 26898398 )
2016
43
Peripheral Vascular Disease and Death in Southern European Kidney Transplant Candidates: A Competing Risk Modeling Approach. ( 27379552 )
2016
44
Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease. ( 26590787 )
2016
45
Comparison of colour duplex ultrasound & ankle brachial index in peripheral vascular disease in type 2 diabetes. ( 27727957 )
2016
46
Identifying beliefs about smoking in patients with peripheral vascular disease. ( 27863591 )
2016
47
Hemorheological parameters better classify metabolic syndrome than novel cardiovascular risk factors and peripheral vascular disease marker. ( 26890105 )
2016
48
Trimetazidine hydrochloride as a new treatment for patients with peripheral vascular disease--an exploratory trial. ( 26813473 )
2016
49
Prevalence of asymptomatic peripheral vascular disease in patients with type-2 diabetes mellitus by colour doppler study. ( 27728049 )
2016
50
Mitochondrial Respiration after One Session of Calf Raise Exercise in Patients with Peripheral Vascular Disease and Healthy Older Adults. ( 27760222 )
2016

Variations for Peripheral Vascular Disease

Expression for Peripheral Vascular Disease

Search GEO for disease gene expression data for Peripheral Vascular Disease.

Pathways for Peripheral Vascular Disease

Pathways related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.55 ALB APOA1 APOB F2 F3 PLAT
2
Show member pathways
12.15 APOB F2 SELE SELP THBD
3
Show member pathways
12.09 ALB APOA1 APOB CRP F2 IL6
4
Show member pathways
12.07 F2 F3 PLAT SERPINC1 SERPINE1 THBD
5 12 PLAT SELE THBD VCAM1 VEGFA
6 11.94 ALB IL6 VCAM1 VEGFA
7 11.94 F2 F3 PLAT SERPINC1 SERPINE1 THBD
8 11.72 IL6 SERPINE1 VEGFA
9
Show member pathways
11.58 IL6 SELE VCAM1 VEGFA
10 11.5 F3 IL6 SELE SERPINE1 THBD VCAM1
11 11.45 APOB IL6 LPA PLAT SELP
12 11.42 IL6 SELE SELP VCAM1
13 11.34 ALB APOA1 F2
14 11.25 APOA1 IL6 SELE VCAM1
15 10.65 PLAT SERPINE1

GO Terms for Peripheral Vascular Disease

Cellular components related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.88 APOA1 F3 PLAT THBD VCAM1 VEGFA
2 extracellular region GO:0005576 9.83 ACE ALB APOA1 APOB CRP F2
3 external side of plasma membrane GO:0009897 9.8 ACE F2 SELP VCAM1
4 extracellular matrix GO:0031012 9.77 APOA1 F3 PLAT SERPINE1 VWF
5 blood microparticle GO:0072562 9.76 ALB APOA1 F2 SERPINC1
6 endoplasmic reticulum lumen GO:0005788 9.73 ALB APOA1 APOB F2 IL6 SERPINC1
7 platelet alpha granule lumen GO:0031093 9.55 ALB PPBP SERPINE1 VEGFA VWF
8 extracellular space GO:0005615 9.55 ACE ALB APOA1 APOB CRP F2
9 low-density lipoprotein particle GO:0034362 9.51 APOA1 APOB
10 chylomicron GO:0042627 9.48 APOA1 APOB
11 intermediate-density lipoprotein particle GO:0034363 9.43 APOA1 APOB
12 extracellular exosome GO:0070062 10.1 ACE ALB APOA1 APOB CRP F2

Biological processes related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.97 F2 IL6 PPBP SERPINE1 VEGFA
2 inflammatory response GO:0006954 9.96 CRP IL6 PPBP SELE SELP
3 post-translational protein modification GO:0043687 9.91 ALB APOA1 APOB IL6 SERPINC1
4 leukocyte migration GO:0050900 9.83 APOB F2 SELE SELP THBD
5 defense response to Gram-negative bacterium GO:0050829 9.8 IL6 SELP SERPINE1
6 cellular protein metabolic process GO:0044267 9.8 ALB APOA1 APOB F2 IL6 SERPINC1
7 response to nutrient GO:0007584 9.79 APOA1 SERPINC1 VCAM1
8 blood coagulation GO:0007596 9.73 F2 F3 PLAT SERPINC1 THBD VWF
9 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.71 SELE SELP VCAM1
10 acute-phase response GO:0006953 9.67 CRP F2 IL6
11 negative regulation of blood coagulation GO:0030195 9.65 SERPINE1 THBD
12 leukocyte cell-cell adhesion GO:0007159 9.65 SELE SELP VCAM1
13 positive regulation of leukocyte migration GO:0002687 9.64 SELP VEGFA
14 positive regulation of blood coagulation GO:0030194 9.64 F2 SERPINE1
15 regulation of blood coagulation GO:0030193 9.63 F2 SERPINC1
16 low-density lipoprotein particle remodeling GO:0034374 9.63 APOB LPA
17 fibrinolysis GO:0042730 9.63 F2 PLAT SERPINE1
18 response to lipopolysaccharide GO:0032496 9.63 APOB PPBP SELE SELP THBD VCAM1
19 positive regulation of positive chemotaxis GO:0050927 9.62 F3 VEGFA
20 chylomicron assembly GO:0034378 9.61 APOA1 APOB
21 neutrophil mediated immunity GO:0002446 9.6 ACE IL6
22 negative regulation of lipid storage GO:0010888 9.59 CRP IL6
23 chylomicron remodeling GO:0034371 9.58 APOA1 APOB
24 negative regulation of platelet activation GO:0010544 9.58 F2 THBD
25 leukocyte tethering or rolling GO:0050901 9.58 SELE SELP VCAM1
26 lipoprotein biosynthetic process GO:0042158 9.55 APOA1 APOB