Peripheral Vascular Disease (PAD)

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Peripheral Vascular Disease

MalaCards integrated aliases for Peripheral Vascular Disease:

Name: Peripheral Vascular Disease 40 12 15 37 17
Peripheral Arterial Disease 40 42 3 62 17
Arterial Occlusive Disease 40 12 15 17
Peripheral Vascular Diseases 54 43 71
Arterial Occlusive Diseases 54 71
Pad 40 3
Peripheral Occlusive Disease 40
Peripheral Arterial Diseases 71
Helicobacter Infections 71


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Disease Ontology 12 DOID:341
ICD9CM 34 443.81
MeSH 43 D016491
SNOMED-CT 67 2929001
ICD10 32 I73.8 I73.9
UMLS 71 C0003838 C0031115 C0079487 more

Summaries for Peripheral Vascular Disease

MedlinePlus : 42 Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of PAD is atherosclerosis. This happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs. Plaque is a substance made up of fat and cholesterol. It causes the arteries to narrow or become blocked. This can reduce or stop blood flow, usually to the legs. If severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg. The main risk factor for PAD is smoking. Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke. Many people who have PAD don't have any symptoms. If you have symptoms, they may include Pain, numbness, achiness, or heaviness in the leg muscles. This happens when walking or climbing stairs. Weak or absent pulses in the legs or feet Sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all A pale or bluish color to the skin A lower temperature in one leg than the other leg Poor nail growth on the toes and decreased hair growth on the legs Erectile dysfunction, especially among men who have diabetes PAD can increase your risk of heart attack, stroke, and transient ischemic attack. Doctors diagnose PAD with a physical exam and heart and imaging tests. Treatments include lifestyle changes, medicines, and sometimes surgery. Lifestyle changes include dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Peripheral Vascular Disease, also known as peripheral arterial disease, is related to grange syndrome and arteriosclerosis obliterans, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Peripheral Vascular Disease is ALB (Albumin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Lipoprotein metabolism. The drugs Ticlopidine and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include Bone, heart and endothelial, and related phenotypes are Decreased free cholesterol and cardiovascular system

Disease Ontology : 12 A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.

CDC : 3 Peripheral Arterial Disease (PAD) in the Legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can occur in any blood vessel, but it is more common in the legs than the arms.

PubMed Health : 62 About peripheral arterial disease: Peripheral arterial disease (P.A.D.) is a disease in which plaque (plak) builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood. When plaque builds up in the body's arteries, the condition is called atherosclerosis (ATH-er-o-skler-O-sis). Over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body. P.A.D. usually affects the arteries in the legs, but it also can affect the arteries that carry blood from your heart to your head, arms, kidneys, and stomach. This article focuses on P.A.D. that affects blood flow to the legs.

Related Diseases for Peripheral Vascular Disease

Diseases related to Peripheral Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 845)
# Related Disease Score Top Affiliating Genes
1 grange syndrome 33.9 VWF VCAM1 SELP SELE PLAT F3
2 arteriosclerosis obliterans 33.2 VCAM1 SELP IL6
3 intracranial arteriosclerosis 32.7 SERPINC1 SELP LPA
4 intermittent claudication 32.1 VWF VEGFA SERPINC1 SELP PF4 IL6
5 hyperlipoproteinemia, type iii 31.6 LPA CETP APOB APOA1
6 aortic aneurysm, familial abdominal, 1 31.4 IL6 CRP CETP ACE
7 limb ischemia 31.4 VWF VEGFA SELE PLAT IL6 F2
8 ischemia 31.3 VEGFA SELP PLAT EPO ACE
9 carotid stenosis 31.2 VEGFA VCAM1 SELP SELE LPA CRP
10 hypertriglyceridemia, familial 31.2 CETP APOB APOA1
11 peripheral nervous system disease 31.2 VEGFA IL6 CRP ALB ACE
12 vascular disease 31.1 VWF VEGFA VCAM1 SERPINC1 SELP SELE
13 end stage renal failure 31.1 SELP IL6 EPO CRP APOB ALB
14 hypercholesterolemia, familial, 1 31.1 LPA CRP CETP APOB APOA1 ACE
15 retinal artery occlusion 31.0 VEGFA SERPINC1 IL6 F2 ACE
16 renal artery disease 31.0 EPO CRP ALB ACE
17 branch retinal artery occlusion 31.0 VEGFA SERPINC1 F3 F2 CRP
18 diabetic neuropathy 31.0 VEGFA EPO ACE
19 cardiogenic shock 31.0 PLAT IL6 CRP
20 chronic ulcer of skin 31.0 VEGFA IL6 CRP ALB
21 peripheral artery disease 31.0 VWF VEGFA VCAM1 SELP IL6 F3
22 congestive heart failure 31.0 VEGFA IL6 EPO CRP ALB ACE
23 microvascular complications of diabetes 5 31.0 VEGFA VCAM1 ALB ACE
24 polyarteritis nodosa 30.9 VCAM1 SELP SELE IL6 CRP
25 angina pectoris 30.9 PLAT LPA IL6 F3 CRP APOA1
26 aortic valve insufficiency 30.9 VWF CRP ALB ACE
27 vasculitis 30.9 VWF VCAM1 SELP SELE IL6 CRP
28 optic nerve disease 30.9 VEGFA IL6 CRP ALB ACE
29 sickle cell disease 30.9 VCAM1 SELP EPO
30 thrombophilia due to thrombin defect 30.9 SERPINC1 PLAT PF4 F3 F2
31 chronic venous insufficiency 30.9 VEGFA VCAM1 SELP PLAT F2 CRP
32 venous insufficiency 30.8 VWF VEGFA VCAM1 SELP PLAT F2
33 generalized atherosclerosis 30.8 VWF LPA IL6 CRP APOB ALB
34 renal hypertension 30.8 EPO ALB ACE
35 rheumatic heart disease 30.8 VCAM1 IL6 ACE
36 glucose intolerance 30.8 IL6 CRP APOB APOA1 ALB ACE
37 carotid artery disease 30.8 SELP SELE PLAT LPA F3 CRP
38 homocysteinemia 30.8 VWF VCAM1 SERPINC1 F2 CRP ALB
39 retinal vascular disease 30.8 VEGFA VCAM1 IL6 CRP ALB ACE
40 antithrombin iii deficiency 30.8 SERPINC1 PF4 F2
41 hyperglycemia 30.8 VCAM1 SELE IL6 APOB ALB
42 systemic scleroderma 30.8 SELP SELE IL6 CRP ACE
43 aortic atherosclerosis 30.8 LPA CETP ACE
44 central retinal artery occlusion 30.7 VEGFA SERPINC1 PLAT LPA F2 CRP
45 cerebrovascular disease 30.7 VWF VCAM1 SELP SELE PLAT LPA
46 cholesterol embolism 30.7 SERPINC1 F2 CRP ACE
47 arteriosclerosis 30.7 VCAM1 SERPINC1 SELP SELE LPA IL6
48 bronchitis 30.7 VEGFA IL6 CRP ALB
49 moyamoya disease 1 30.7 VWF VEGFA SERPINC1 LPA F3 F2
50 lipid metabolism disorder 30.7 SELE LPA IL6 CRP CETP APOB

Comorbidity relations with Peripheral Vascular Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 95)

Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Vascular Insufficiency of Intestine Anxiety
Aortic Aneurysm Aortic Atherosclerosis
Aortic Valve Disease 1 Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Renovascular Hypertension Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Buerger Disease Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Pulmonary Heart Disease Chronic Ulcer of Skin
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetes Mellitus, Noninsulin-Dependent
Diabetic Peripheral Angiopathy Diabetic Polyneuropathy
Dressler's Syndrome Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Gas Gangrene
Generalized Atherosclerosis Gout
Heart Disease Hyperlipoproteinemia, Type Iv
Hyperlipoproteinemia, Type V Hypertension, Essential
Hypertensive Encephalopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma
Hypothyroidism Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Peripheral Vascular Disease:

Diseases related to Peripheral Vascular Disease

Symptoms & Phenotypes for Peripheral Vascular Disease

UMLS symptoms related to Peripheral Vascular Disease:

angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.02 APOA1 APOB CETP LPA SELP

MGI Mouse Phenotypes related to Peripheral Vascular Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 ACE ALB APOA1 APOB CRP EPO
2 homeostasis/metabolism MP:0005376 10.3 ACE ALB APOA1 APOB CRP EPO
3 hematopoietic system MP:0005397 10.22 ACE EPO F2 F3 IL6 PF4
4 cellular MP:0005384 10.21 ALB APOA1 APOB EPO F3 IL6
5 immune system MP:0005387 10.2 ACE ALB APOB CRP EPO F2
6 integument MP:0010771 9.91 APOA1 EPO F2 F3 IL6 PLAT
7 liver/biliary system MP:0005370 9.85 ACE ALB APOA1 APOB EPO IL6
8 mortality/aging MP:0010768 9.8 ACE ALB APOB EPO F2 F3
9 respiratory system MP:0005388 9.23 EPO F2 F3 IL6 PLAT SELE

Drugs & Therapeutics for Peripheral Vascular Disease

PubMed Health treatment related to Peripheral Vascular Disease: 62

Treatments for peripheral arterial disease (P.A.D.) include lifestyle changes, medicines, and surgery or procedures. The overall goals of treating P.A.D. include reducing symptoms, improving quality of life, and preventing complications. Treatment is based on your signs and symptoms, risk factors, and results from a physical exam and tests. Treatment may slow or stop disease progress and reduce the risk of complications. Without treatment, P.A.D. can cause sores or gangrene (tissue death). In extreme cases, it may be necessary to remove part of the leg or foot (amputation ).

Drugs for Peripheral Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 596)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ticlopidine Approved Phase 4 55142-85-3 5472
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
Acetaminophen Approved Phase 4 103-90-2 1983
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
Capsaicin Approved Phase 4 404-86-4 1548943
Dinoprostone Approved Phase 4 363-24-6 5280360
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
Paclitaxel Approved, Vet_approved Phase 4 33069-62-4 36314
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
Methyltestosterone Approved Phase 4 58-18-4 6010
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 6013 10204
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
Testosterone enanthate Approved Phase 4 315-37-7 9416
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
Ezetimibe Approved Phase 4 163222-33-1 150311
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
Dobutamine Approved Phase 4 34368-04-2 36811
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
Clonidine Approved Phase 4 4205-90-7 2803
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Defibrotide Approved, Investigational Phase 4 83712-60-1
Piperacillin Approved Phase 4 66258-76-2 43672
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
Nitazoxanide Approved, Investigational, Vet_approved Phase 4 55981-09-4 41684
Pantoprazole Approved Phase 4 102625-70-7 4679
Bismuth subsalicylate Approved, Vet_approved Phase 4 14882-18-9 53629521
Loperamide Approved Phase 4 53179-11-6 3955
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5280427 5282411
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
Abacavir Approved, Investigational Phase 4 136470-78-5 65140 441300
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
Coal tar Approved Phase 4 8007-45-2
Norepinephrine Approved Phase 4 51-41-2 439260
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
Tazobactam Approved Phase 4 89786-04-9 123630
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
Allantoin Approved Phase 4 97-59-6 204
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Triflusal Approved, Investigational Phase 4 322-79-2

Interventional clinical trials:

(show top 50) (show all 1741)
# Name Status NCT ID Phase Drugs
1 Randomized Trial of Paclitaxel Eluting Balloon or Conventional Balloon for Treatment of In-Stent Restenosis of the Superficial Femoral Artery in Patients With Symptomatic Peripheral Artery Disease (ISAR-PEBIS) Unknown status NCT01083394 Phase 4
2 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
3 Platelets Induced Vasodilation, in Vitro and in Vivo Study in Patients With Arteriopathy and Healthy Subjects. Unknown status NCT00152646 Phase 4 placebo, aspirine, clopidogrel
4 SAFE (Sarpogrelate Anplone in Femoro-popliteal Artery Intervention Efficacy) Study : a Randomized Controlled Trial Unknown status NCT02959606 Phase 4 Sarpogrelate SR 300mg;Clopidogrel
5 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis (PESETA) Unknown status NCT02033135 Phase 4
6 Randomized Trial of Stenting After Dilation With or Without Paclitaxel Eluting Balloon or Atherectomy in Patients With Symptomatic Peripheral Artery Disease Unknown status NCT00986752 Phase 4
7 A Randomized Controlled Trial Comparing Usual Care With a Multifactorial Intensified Intervention on Cardiovascular Risk Factors in Subjects With Arterial Peripheral Disease With and Without Diabetes. The Taulí Intervention Program (TIP). Unknown status NCT00144937 Phase 4 Stepwise therapy for dyslipidemia, hypertension and diabetes
8 Evaluation of Closed Incision Negative Pressure Device (Prevena) to Prevent Vascular Wound Complications Unknown status NCT02581904 Phase 4
9 Tailored Strategy for Residual Platelet Activity In Advanced Peripheral Artery Disease: New Optimal Management. Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
10 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROLTM Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease : Prospective, Multicenter, Randomized, Controlled Trial (SENS-FP-2 Trial) Unknown status NCT01653600 Phase 4
11 Comparison Efficacy of 14-day Triple Therapy Between Clarithromycin and Levofloxacin on the Eradication of Helicobacter Pylori in Syrian Population Unknown status NCT02693574 Phase 4 Clarithromycin;Levofloxacin
12 The Study to Compare the Treatment of Stent and Prothesis Bypass in SFA Occlusions Unknown status NCT01147419 Phase 4
13 Paclitaxel-eluting Balloon Angioplasty With Provisional Use of Nitinol Stent Versus Systematic Implantation of Paclitaxel-eluting Stent for the Treatment of Femoropopliteal de Novo Lesions Unknown status NCT01969630 Phase 4
14 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
15 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Unknown status NCT02563535 Phase 4
16 Study of the OmniWave Endovascular System in Subjects With Lower and Upper Extremity Deep Vein Thrombosis - SONIC I Study Unknown status NCT00640731 Phase 4
17 Estimation de la capacité Fonctionnelle à la Marche Par Questionnaire Clinique Chez Les Patients adressés Pour Bilan artériel Des Membres inférieurs Unknown status NCT01424020 Phase 4
18 A Randomized, Double-blind, Placebo-controlled Study of the Usefulness of the Probiotic 'Lactobacillus Reuteri' in the Therapy of Quadruple Eradication of Helicobacter Pylori Infection in Usual Clinical Practice Unknown status NCT03150394 Phase 4
19 The Effects of Pravastatin and Rosuvastatin on the Tissue Characteristics and Morphology of Coronary Plaques in Patients With Stable Angina Pectoris Unknown status NCT01325818 Phase 4 pravastatin, rosuvastatin
20 Comparison of the Eradications Rates of Sequential Therapy Versus Concomitant Therapy of Treatment of Helicobacter Pylori Infection in Korea Unknown status NCT02108184 Phase 4 Sequential therapy 10 days;Sequential therapy 14 days;Concomitant therapy 10 days;Concomitant therapy 14 days
21 Comparison of the Efficacy of Clarithromycin-based Triple Therapy Versus Quadruple Therapies in the First Line Therapy of Helicobacter Pylori Infection- A Multicenter Randomized Comparative Trial Unknown status NCT01906879 Phase 4 triple, quadruple, non-bismuth quadruple therapy
22 EVALUATION OF THE RELATIONSHIP BETWEEN EFFERVESCENT PARACETAMOL AND BLOOD PRESSURE. CLINICAL TRIAL. Unknown status NCT02514538 Phase 4 Non- effervescent Paracetamol kern;Effervescent paracetamol termalgin
23 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT)-A Randomized Controlled Trial Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
24 Comparison of Triple Therapy Regimens Effectiveness Over 10 Days and 14 Days in Eradication of Helicobacter Pylori Infection: Double Blind Randomized Clinical Trial Unknown status NCT03134378 Phase 4 Rabeprazole Sodium 20mg;Clarithromycin 500mg;Amoxicillin 500 Mg
25 Peripheral Artery Disease in Patients on Maintenance Hemodialysis: Risk Factors and the Effect of FIR Therapy Unknown status NCT01095549 Phase 4
26 The Effect of Far Infrared (FIR) Therapy on Access Flow of Arteriovenous (AV) Fistula, Echocardiographic Parameters and Endothelial Function in Patients With End Stage Renal Disease Unknown status NCT01138254 Phase 4
27 Comparison of the Efficacy of Triple Therapy With or Without Acetylcysteine in the First Line of Helicobacter Pylori Infection- A Multicenter Randomized Comparative Trial Unknown status NCT02249546 Phase 4 N-acetylcysteine + PPI-amoxicillin-clarithromycin;PPI-amoxicillin-clarithromycin
28 The Role of Qutenza (Topical Capsaicin 8%) in Treating Neuropathic Pain From Critical Ischaemia in Patients With End-stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
29 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
30 Assessment of the Effects of the Combination of Spironolactone to Conventional Pharmacotherapy in Dialysis Patients Unknown status NCT01128101 Phase 4 Spironolactone
31 Endovascular Treatment Versus Optimal Medical Treatment of Atherosclerotic Renal Artery for Preserving Renal Function of the Ischemic Kidney. Unknown status NCT01208714 Phase 4 Optimal medical therapy
32 The Jetstream G2 System Post-Market Peripheral Vascular IVUS Study Completed NCT00911417 Phase 4
33 Jetstream NAVITUS™ System Endovascular Therapy Post-market Registry (JET) Completed NCT01436435 Phase 4
34 A Clinical Study of Gadoteric Acid in Non-Coronary Magnetic Resonance (MR) Completed NCT00447889 Phase 4 gadoteric acid
35 Multinational, Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel Groups Study to Assess the Efficacy and Safety of Prostaglandin E1 in Subjects With Critical Limb Ischemia (Fontaine Stage IV) Completed NCT00596752 Phase 4 Alprostadil
36 A Phase IV Multi-Center Study to Compare ISOVUE -250 and VISIPAQUE 270 for Motion Artifact and Pain in Peripheral Digital Subtraction Angiography (DSA) Completed NCT01075217 Phase 4 iopamidol;iodixanol
37 Femoral Artery In-Stent Restenosis (FAIR) Trial Completed NCT01305070 Phase 4
38 A Randomised, Double Blind, Placebo Controlled, Parallel Pilot Study to Test the Effect of Testosterone Treatment on Peripheral Vascular Disease in Hypogonadal Men With Type 2 Diabetes Mellitus Completed NCT00504712 Phase 4 Testosterone;saline
39 4-EVER Study - Physician-Initiated Trial Investigating the Safety of the Full 4F Endovascular Treatment Approach of Infra-Inguinal Arterial Stenotic Disease Completed NCT01413139 Phase 4
40 Physician Initiated Multi-center Belgian-Italian-Dutch Trial Investigating Abbott Vascular Iliac Stents in the Treatment of TASC A, B, C & D Iliac Lesions Completed NCT00764777 Phase 4
41 A Randomised, Double Blind, Placebo-controlled Parallel Study to Test the Effect of Testosterone Treatment on Peripheral Vascular Disease in Hypogonadal Men With Type 2 Diabetes Mellitus Completed NCT00355537 Phase 4 Testosterone;0.9% saline
42 Physician Initiated Trial Investigating the Efficacy of the Implant of EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
43 The Effect of High Dose Arginine Infusion on Hemodynamic and Peripheral Microcirculation: a Randomized, Controlled Clinical Trial in Patients Receiving Peripheral Vascular Surgery Completed NCT01682889 Phase 4
44 Intermittent Mechanical Compression For Peripheral Arterial Disease Completed NCT00855673 Phase 4 Control
45 The GORE VIABAHN® Endoprosthesis With PROPATEN Bioactive Surface Versus Plain Old Balloon Angioplasty (POBA) for the Treatment of Superficial Femoral Artery (SFA) In-Stent Restenosis Completed NCT01108861 Phase 4
46 The Effect of Angioplasty in Peripheral Arterial Disease on Endothelial Function Completed NCT00660634 Phase 4
47 The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease Completed NCT00168467 Phase 4 Ramipril
48 Drug Eluting Balloon in peripherAl inTErvention: the DEBATE SFA Study Completed NCT01556542 Phase 4
49 A Prospective, Single-Arm Study to Evaluate the Effects of the Jetstream G3 System on Calcified Peripheral Vascular Lesions Completed NCT01273623 Phase 4
50 A Phase IV Pilot Study to Compare ISOVUE®-250 and VISIPAQUE™ 270 for Motion Artifact and Pain in Peripheral Digital Subtraction Angiography (DSA) Completed NCT00740207 Phase 4 VISIPAQUE 270;Isovue 250

Search NIH Clinical Center for Peripheral Vascular Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :

bismuth subcarbonate
bismuth subcitrate
bismuth subgallate
bismuth subnitrate
bismuth subsalicylate
Cimetidine Hydrochloride
Epoprostenol Sodium
Esomeprazole magnesium
esomeprazole sodium
Esomeprazole Strontium
Metronidazole Hydrochloride
Omeprazole 2 MG/ML Oral Suspension
Omeprazole magnesium
Pantoprazole sodium
Papaverine Hydrochloride
Tolazoline Hydrochloride

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Peripheral Vascular Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Peripheral Vascular Disease:
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
TGI PVG, adipose-derived stem cell-coated vascular graft for peripheral vascular disease
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
MultiGeneAngio, genetically modified endothelial and smooth muscle cells for vascular disease
Enriched bone marrow-derived progenitor cells for ischemic diseases
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ACY001, bone marrow-derived hematopoietic stem cells for coronary artery occlusions
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
ALD-301, bone marrow-derived cells for critical limb ischemia
Endothelial progenitor cells for peripheral artery disease
MultiStem, bone marrow-derived cells for peripheral vascular disease
VASCUGEL, aortic endothelial cells for vascular injury and disease
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Embryonic/Adult Cultured Cells Related to Peripheral Vascular Disease:
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905 19324906
Cord blood-derived hematopoietic stem cell PMIDs: 19558779
Peripheral blood-derived endothelial cells PMIDs: 18388019 19448678
Peripheral blood-derived hematopoietic stem cells PMIDs: 18388019
Peripheral blood-derived endothelial progenitor cells PMIDs: 10725398
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 21175285 23307829
Adipose-derived stromal cells PMIDs: 8207032 23350681
Aortic endothelial cells cultured in matrix PMIDs: 7667257
Aortic endothelial cells cultured in matrix (VASCUGEL) PMIDs: 7667257
Genetically modified vein-derived endothelial cells
MultiGeneAngio, transduced vein-derived endothelial cells
Bone marrow-derived mononuclear cells
Bone marrow-derived progenitor cells
Bone marrow-derived mononuclear cells
Bone marrow-derived CD133+ stem cells
MultiGeneAngio, transduced vein-derived smooth muscle cells
Genetically modified vein-derived smooth muscle
Bone marrow-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: peripheral vascular diseases

Genetic Tests for Peripheral Vascular Disease

Anatomical Context for Peripheral Vascular Disease

MalaCards organs/tissues related to Peripheral Vascular Disease:

Heart, Endothelial, Kidney, Bone, Testes, Skin, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Peripheral Vascular Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Peripheral Vascular Disease

Articles related to Peripheral Vascular Disease:

(show top 50) (show all 16771)
# Title Authors PMID Year
Effects of sarpogrelate hydrochloride on peripheral arterial disease: A meta-analysis of randomized controlled trials. 61 42
31725602 2019
Nailfold Video Capillaroscopy: Beyond Systemic Sclerosis. 42
31507130 2019
The relationship between Raynaud's phenomenon and Helicobacter pylori. 42
31747762 2019
Trends in patient characteristics and first-year medical costs of older incident hemodialysis patients, 1995-2005. 54 61
20116913 2010
Predicting six-month mortality for patients who are on maintenance hemodialysis. 54 61
19965531 2010
Peritoneal protein clearance and not peritoneal membrane transport status predicts survival in a contemporary cohort of peritoneal dialysis patients. 54 61
19478100 2009
Exercise and limitations in physical activity levels among new dialysis patients in the United States: an epidemiologic study. 54 61
19041586 2008
Effects of peripheral vascular intervention on ischemia-modified albumin. 54 61
17627187 2007
Angiotensin converting enzyme inhibition in cardiovascular risk populations: a practical approach to identify the patient who will benefit most. 54 61
17556876 2007
ACE gene polymorphism in peripheral vascular disease. 54 61
17611909 2007
Evaluation of a protocol for prevention of facility-acquired heel pressure ulcers. 54 61
17413835 2007
A perspective on telmisartan and cardiovascular risk. 54 61
17938615 2007
Peripheral arterial disease: a review of disease awareness and management. 54 61
17296541 2006
Optimal medical management of peripheral arterial disease. 54 61
16959725 2006
The impact of topical mupirocin on peritoneal dialysis infection in Singapore General Hospital. 54 61
16046516 2005
The impact of topical mupirocin on peritoneal dialysis infection rates in Singapore General Hospital. 54 61
15855200 2005
A high calcium-phosphate product is associated with high C-reactive protein concentrations in hemodialysis patients. 54 61
16103720 2005
Validation of the Kidney Disease Quality of Life (KDQOL) cognitive function subscale. 54 61
15569327 2004
Ischemia-modified albumin concentrations in patients with peripheral vascular disease and exercise-induced skeletal muscle ischemia. 54 61
15265817 2004
[The metabolic syndrome in patients with type 1 diabetes mellitus. Associations with cardiovascular risk factors and cardiovascular morbidity]. 54 61
15340731 2004
[Diabetes and atherosclerotic coronary damage in uremia]. 54 61
15356846 2004
Relationship between diabetes mellitus and degree of coronary artery disease in uraemic patients investigated with coronary angiography. 54 61
12703884 2003
Hypertension as a determinant of survival for patients treated with home dialysis. 54 61
12427157 2002
Lack of association between angiotensin-converting enzyme gene polymorphism and peripheral vascular disease in type 2 diabetic patients in Taiwan. 54 61
12419932 2002
Association of serum albumin and atherosclerosis in chronic hemodialysis patients. 54 61
12324906 2002
Minimally invasive vein harvesting significantly reduces pain and wound morbidity. 54 61
12204728 2002
Smoking causes a dose-dependent increase in granulocyte-bound L-selectin. 54 61
12165281 2002
Pre-dialysis clinic attendance improves quality of life among hemodialysis patients. 54 61
11934351 2002
The effect of peripheral vascular disease on the serum levels of natural anti-oxidants: bilirubin and albumin. 54 61
11941273 2002
From the HOPE to the ONTARGET and the TRANSCEND studies: challenges in improving prognosis. 54 61
11835907 2002
Determinants of physical performance in ambulatory patients on hemodialysis. 54 61
11576377 2001
Cross-sectional and longitudinal predictors of serum albumin in hemodialysis patients. 54 61
11044233 2000
Prostaglandin E1-therapy reduces circulating adhesion molecules (ICAM-1, E-selectin, VCAM-1) in peripheral vascular disease. 54 61
11037715 2000
Randomized, placebo-controlled trial of the angiotensin-converting enzyme inhibitor, ramipril, in patients with coronary or other occlusive arterial disease. PART-2 Collaborative Research Group. Prevention of Atherosclerosis with Ramipril. 54 61
10933355 2000
The anti-ischemic potential of angiotensin-converting enzyme inhibition: insights from the heart outcomes prevention evaluation trial. 54 61
10894450 2000
The effect of small solute clearances on survival of anuric peritoneal dialysis patients. 54 61
10809241 2000
Net mass transfer of plasma cholesteryl esters and lipid transfer proteins in normolipidemic patients with peripheral vascular disease. 54 61
10582542 1999
A randomized trial of endoscopic versus open saphenous vein harvest in coronary bypass surgery. 54 61
10543556 1999
Transvascular and urinary leakage of albumin in atherosclerotic and hypertensive men. 54 61
9719061 1998
Total body nitrogen predicts long-term mortality in haemodialysis patients--a single-centre experience. 54 61
9681720 1998
[Current pharmaco-therapeutic strategies in the treatment of arterial hypertension]. 54 61
9813738 1998
Soluble P-selectin in atherosclerosis: a comparison with endothelial cell and platelet markers. 54 61
9241735 1997
von Willebrand factor: a marker of endothelial dysfunction in vascular disorders? 54 61
9205537 1997
Cell adhesion molecules and insulin-like growth factor-1 in vascular disease. 54 61
9152314 1997
Urinary albumin excretion rate and cardiovascular disease in Spaniard type 2 diabetic patients. 54 61
9229197 1997
Lipid profile and peripheral vascular disease in arseniasis-hyperendemic villages in Taiwan. 54 61
9112880 1997
Incidence of distal symmetric (sensory) neuropathy in NIDDM. The San Luis Valley Diabetes Study. 54 61
9051381 1997
Predictors of 10-year macrovascular and overall mortality in patients with NIDDM: the Munich General Practitioner Project. 54 61
8960840 1996
Soluble P selectin in peripheral vascular disease: relationship to the location and extent of atherosclerotic disease and its risk factors. 54 61
9034560 1996
A model that predicts morbidity and mortality after coronary artery bypass graft surgery. 54 61
8890808 1996

Variations for Peripheral Vascular Disease

Expression for Peripheral Vascular Disease

Search GEO for disease gene expression data for Peripheral Vascular Disease.