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MCID: PRP028
MIFTS: 39

Peripheral Vertigo

Categories: Ear diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Peripheral Vertigo

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MalaCards integrated aliases for Peripheral Vertigo:

Name: Peripheral Vertigo 12 15
Vertigo, Peripheral 71

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9847
ICD9CM 34 386.1 386.19
UMLS 71 C0029706 C0155501
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Summaries for Peripheral Vertigo

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MalaCards based summary : Peripheral Vertigo, also known as vertigo, peripheral, is related to vestibular neuronitis and meniere disease, and has symptoms including vertigo An important gene associated with Peripheral Vertigo is CRP (C-Reactive Protein), and among its related pathways/superpathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). The drugs Dimenhydrinate and Antiemetics have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and neutrophil, and related phenotypes are homeostasis/metabolism and hearing/vestibular/ear

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Related Diseases for Peripheral Vertigo

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Diseases related to Peripheral Vertigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 vestibular neuronitis 30.8 RTEL1 OTOL1 CACNA1A
2 meniere disease 30.7 FAM136A COCH AQP2
3 arachnoiditis 30.4 CRP CRLF1
4 migraine with or without aura 1 30.3 F2 CRP CACNA1A APOH
5 labyrinthitis 30.2 SLC26A4 GJB2 CRLF1 COCH
6 thrombophilia due to activated protein c resistance 30.1 SERPINC1 F5 F3 F2 APOH
7 benign paroxysmal positional nystagmus 29.7 RTEL1 OTOP1 OTOL1 OTOG CACNA1A
8 inner ear disease 29.5 SLC26A4 RTEL1 GJB2 COCH CACNA1A
9 vestibular disease 27.3 SLC26A4 RTEL1 OTOP1 OTOL1 OTOG KCNE1
10 orbital osteomyelitis 10.6 F2 CRP
11 arteritic anterior ischemic optic neuropathy 10.6 F5 F2
12 small intestine diverticulitis 10.6 F2 CRP
13 may-thurner syndrome 10.6 F5 APOH
14 paracetamol poisoning 10.6 F5 F2
15 gastric hemangioma 10.6 F3 F2
16 cardiac tuberculosis 10.6 SERPINC1 CRP
17 acanthamoeba keratitis 10.6 F5 APOH
18 acquired angioedema 10.6 F5 CRP
19 papillary adenofibroma 10.6 F3 F2
20 acquired hemophilia 10.6 F5 F3
21 acquired hemophilia a 10.6 F5 F3
22 heparin-induced thrombocytopenia 10.6 SERPINC1 F3
23 necrotizing gastritis 10.6 F2 CRP
24 vulvar angiokeratoma 10.6 SERPINC1 F3
25 femoral neuropathy 10.6 F3 F2
26 lateral sinus thrombosis 10.6 SERPINC1 F2
27 sticky platelet syndrome 10.6 SERPINC1 F5
28 waterhouse-friderichsen syndrome 10.6 SERPINC1 F2
29 qualitative platelet defect 10.6 F3 F2
30 splenic abscess 10.6 F2 CRP
31 ascending cholangitis 10.5 F2 CRP
32 puerperal pulmonary embolism 10.5 SERPINC1 APOH
33 epidural abscess 10.5 F3 CRP
34 synovial angioma 10.5 F3 F2 CRP
35 renal pelvis squamous cell carcinoma 10.5 F3 F2 CRP
36 cryptogenic cirrhosis 10.5 F5 F2
37 livedoid vasculitis 10.5 SERPINC1 F2
38 emphysematous cholecystitis 10.5 F3 F2 CRP
39 acalculous cholecystitis 10.5 F2 CRP
40 lemierre's syndrome 10.5 F3 F2 CRP
41 thoracic outlet syndrome 10.5 SERPINC1 F2
42 prothrombin deficiency 10.5 SERPINC1 F3 F2
43 active peptic ulcer disease 10.5 F3 F2 CRP
44 hemopericardium 10.5 F3 F2
45 cavernous sinus thrombosis 10.5 SERPINC1 F2 CRP
46 mediastinitis 10.5 F5 F2 CRP
47 cardiac tamponade 10.5 F3 F2 CRP
48 fournier gangrene 10.5 SERPINC1 F3 F2
49 leech infestation 10.5 SERPINC1 F3
50 anuria 10.5 F3 F2 CRP

Comorbidity relations with Peripheral Vertigo via Phenotypic Disease Network (PDN):


Hypertension, Essential Labyrinthitis

Graphical network of the top 20 diseases related to Peripheral Vertigo:



Diseases related to Peripheral Vertigo
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Symptoms & Phenotypes for Peripheral Vertigo

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UMLS symptoms related to Peripheral Vertigo:


vertigo

MGI Mouse Phenotypes related to Peripheral Vertigo:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.77 APOH AQP2 AVP CACNA1A CRP F2
2 hearing/vestibular/ear MP:0005377 9.63 COCH GJB2 KCNE3 OTOG OTOP1 SLC26A4
3 nervous system MP:0003631 9.44 AVP CACNA1A CRLF1 F2 F3 F5
Sources

Drugs & Therapeutics for Peripheral Vertigo

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Drugs for Peripheral Vertigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dimenhydrinate Approved Phase 4 523-87-5 441281
2 Antiemetics Phase 4
3 Gastrointestinal Agents Phase 4
4 Histamine Antagonists Phase 4
5 Histamine H1 Antagonists Phase 4
6
Histamine Approved, Investigational Phase 3 51-45-6 774
7
Meclizine Approved Phase 3 569-65-3 4034
8
Lorazepam Approved Phase 3 846-49-1 3958
9
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
10
Promethazine Approved, Investigational Phase 3 60-87-7 4927
11
Cilostazol Approved, Investigational Phase 3 73963-72-1 2754
12 Neurotransmitter Agents Phase 3
13
Histamine Phosphate Phase 3 51-74-1 65513
14 Anti-Anxiety Agents Phase 3
15 Anesthetics, Local Phase 3
16 Tranquilizing Agents Phase 3
17 Anesthetics Phase 3
18 Hypnotics and Sedatives Phase 3
19 GABA Agents Phase 3
20 Psychotropic Drugs Phase 3
21 Antipruritics Phase 3
22 GABA Modulators Phase 3
23 Dermatologic Agents Phase 3
24 Anticonvulsants Phase 3
25 Central Nervous System Depressants Phase 3
26 Anti-Allergic Agents Phase 3
27 Autonomic Agents Phase 3
28 Vasodilator Agents Phase 3
29 Fibrinolytic Agents Phase 3
30 Anti-Asthmatic Agents Phase 3
31 Platelet Aggregation Inhibitors Phase 3
32 Respiratory System Agents Phase 3
33 Neuroprotective Agents Phase 3
34 Phosphodiesterase Inhibitors Phase 3
35 Protective Agents Phase 3
36 Bronchodilator Agents Phase 3
37 Phosphodiesterase 3 Inhibitors Phase 3
38 Ginkgo Phase 3
39
Betahistine Approved, Investigational Phase 2 5638-76-6 2366
40 Pharmaceutical Solutions Phase 2
41 Hemostatics
42 Natriuretic Agents
43 Vasoconstrictor Agents
44 Arginine Vasopressin
45 Coagulants
46 Vasopressins
47
Arginine Investigational, Nutraceutical 74-79-3 6322

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo: A Double Blind Randomized Clinical Trial Completed NCT01890538 Phase 4 Administration of 100 mg dimenhydrinate intravenous;2 g piracetam intravenous
2 " National, Phase III, Radomized, Double-Blind, Double -Dummy, Controlled, Parallel to Evaluate Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) Soft Gel Capsules in the Control of Acute Vertigo Symphtoms From Peripheral Origin" Unknown status NCT02112578 Phase 3 Meclizine;Dimenhydrinate
3 Promethazine vs. Lorazepam for Treatment of Vertigo in the Emergency Department: A Randomized Clinical Trial Completed NCT01827293 Phase 3 Promethazine;Lorazepam
4 A Single-center, Prospective, Randomized, Parallel Group, Placebo-controlled Exploratory Study on the Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3 Renexin (cilostazol 100mg + gingko biloba extract 80 mg);Placebo
5 Multicenter Randomized Controlled Phase 2 Trial to Evaluate AM-125 in the Treatment of Acute Peripheral Vertigo Following Vestibular Schwannoma Resection (TRAVERS) Recruiting NCT03908567 Phase 2 Intranasal Drug;Oral Tablet
6 Evaluation of Thiol/Disulfide Homeostasis and Ischemia Modified Albumin Levels in the Differential Diagnosis of Central and Peripheral Vertigo Completed NCT04070664
7 Value of Copeptin and the S-100b Protein Assay in Ruling Out the Diagnosis of Stroke-induced Dizziness Pattern in Emergency Departments Completed NCT03974464
8 Effect of the Cranial Osteopathic Techniques on the Symptoms of Benign Paroxysmal Positional Vertigo Completed NCT03854084

Search NIH Clinical Center for Peripheral Vertigo

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Genetic Tests for Peripheral Vertigo

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Anatomical Context for Peripheral Vertigo

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MalaCards organs/tissues related to Peripheral Vertigo:

40
Heart, Testes, Neutrophil, Eye, Bone, Brain, Skin
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Publications for Peripheral Vertigo

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Articles related to Peripheral Vertigo:

(show top 50) (show all 221)
# Title Authors PMID Year
1
Prevalence and Risk Factors of White Matter Lesions in Tibetan Patients Without Acute Stroke. 61
31679502 2020
2
Determination of Anxiety, Health Anxiety and Somatosensory Amplification Levels in Individuals with Benign Paroxysmal Positional Vertigo. 61
31347508 2019
3
Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: A case-control study and meta-analysis. 61
31521916 2019
4
Cinnarizine/betahistine combination vs. the respective monotherapies in acute peripheral vertigo: a randomized triple-blind placebo-controlled trial. 61
31420703 2019
5
Management of peripheral vertigo with antihistamines: New options on the horizon. 61
31269270 2019
6
Recovery of ocular and cervical vestibular evoked myogenic potentials after treatment of inner ear diseases. 61
31070081 2019
7
[How to initially screen common central "malignant vertigo" at the bedside?] 61
31434383 2019
8
Safety and predictors of stroke mimics in The Norwegian Tenecteplase Stroke Trial (NOR-TEST). 61
30019629 2019
9
A Case of Isolated Nodular Infarction Mimicking Vestibular Neuritis on the Contralateral Side. 61
31234246 2019
10
Effects of vestibular rehabilitation, with or without betahistine, on managing residual dizziness after successful repositioning manoeuvres in patients with benign paroxysmal positional vertigo: a protocol for a randomised controlled trial. 61
31217316 2019
11
Identification of Factors Related to Cases of Benign Paroxysmal Positional Vertigo Refractory to Canalicular Repositioning Maneuvers and Evaluation of the Need for Magnetic Resonance Imaging in their Management: Retrospective Analysis of a Series of 176 Cases. 61
30956705 2019
12
Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study. 61
30837524 2019
13
Neurologic manifestations of elderly patients with cancer. 61
29704209 2019
14
Peripheral Vertigo. 61
30454774 2019
15
Innovative Use of Google Cardboard in Clinical Examination of Patients of Vertigo. 61
31673230 2019
16
Misdiagnosis of acute ischemic stroke in young patients. 61
31048273 2019
17
Long-term outcomes of triple semicircular canal plugging for the treatment of intractable Meniere's disease: A single center experience of 361 cases. 61
31640108 2019
18
Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? 61
30268346 2019
19
Oral Piracetam vs Betahistine in Outpatient Management of Peripheral Vertigo; a Randomized Clinical Trial. 61
30847444 2019
20
[Suppression head impulse paradigm in healthy adult population: the values and features of the parameters]. 61
30585003 2018
21
Nimodipine for the treatment of otolaryngic indications. 61
30190294 2018
22
Usage of the HINTS exam and neuroimaging in the assessment of peripheral vertigo in the emergency department. 61
30201056 2018
23
Physical therapy in the emergency department: A new opportunity for collaborative care. 61
29853343 2018
24
Efficacy of particle repositioning manoeuvres in benign positional paroxysmal vertigo: A revision of 176 cases treated in a tertiary care centre. 61
28965618 2018
25
Utility of Neutrophil-to-Lymphocyte Ratio (NLR) as a Predictor of Acute Infarction in New-Onset Acute Vertigo Patients Without Neurologic and Computed Tomography Abnormalities. 61
29398242 2018
26
Analysis of Risk Factors in Patients With Peripheral Vertigo or Central Vertigo. 61
29722738 2018
27
Referral patterns from emergency department to otolaryngology clinic. 61
29152746 2018
28
Central vertigo. 61
29084063 2018
29
Decompensated labyrinthine weakness presenting as de novo peripheral vertigo: a discrete clinical entity? 61
29343311 2018
30
Assessment of the effect of mesoglycan in the treatment of audiovestibular disorders of vascular origin. 61
29734824 2018
31
[Stroke mimicking acute peripheral vertigo: how to avoid misdiagnosis - importance of alarm symptoms and assessment of eye movements]. 61
29623865 2018
32
[Approach to patients with vertigo]. 61
30504108 2018
33
Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication. 61
30079052 2018
34
The impact of opioid medications on subsequent fractures in discharged emergency department patients with peripheral vertigo. 61
28631577 2018
35
Threat of a Cycle Proof: Vertebral Artery Dissection Associated with Posterior Inferior Cerebellar Artery Infarction. 61
30687555 2018
36
[The diagnostic significance of vestibular evoked myogenic potentials in different types of vertigo]. 61
29460899 2018
37
Author response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. 61
29335312 2018
38
New Onset Focal Stabbing Headache Associated With Peripheral Vertigo: A Case Report. 61
29034450 2018
39
Reader response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. 61
29335311 2018
40
A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency. 61
29163732 2017
41
Health-related quality of life and disability in patients with acute unilateral peripheral vestibular disorders. 61
27595924 2017
42
Advances in the diagnosis and treatment of benign paroxysmal positional vertigo. 61
28962176 2017
43
A safe-repositioning maneuver for the management of benign paroxysmal positional vertigo: Gans vs. Epley maneuver; a randomized comparative clinical trial. 61
27488837 2017
44
Italian survey on benign paroxysmal positional vertigo. 61
28872163 2017
45
Isolated transient vertigo: posterior circulation ischemia or benign origin? 61
28615008 2017
46
Diagnostic value of repeated Dix-Hallpike and roll maneuvers in benign paroxysmal positional vertigo. 61
27170347 2017
47
[The diagnosis, treatment and aviation medicine identification of vestibular neuronitis]. 61
29871338 2017
48
Classification, diagnostic criteria and management of benign paroxysmal positional vertigo. 61
27174206 2017
49
Effects of Semont maneuver on benign paroxysmal positional vertigo: a meta-analysis. 61
27683970 2017
50
Age-Related Increases in Benign Paroxysmal Positional Vertigo Are Reversed in Women Taking Estrogen Replacement Therapy: A Population-Based Study in Taiwan. 61
29311896 2017
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Variations for Peripheral Vertigo

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Expression for Peripheral Vertigo

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Search GEO for disease gene expression data for Peripheral Vertigo.
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Pathways for Peripheral Vertigo

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Pathways related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Collagen chain trimerization 65
Show member pathways
 12.28 SERPINC1 KCNE3 F5 F3 F2
2
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.46 SERPINC1 F5 F3 F2
3
Complement and coagulation cascades 1 36
11.09 SERPINC1 F5 F3 F2
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GO Terms for Peripheral Vertigo

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Cellular components related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 SERPINC1 OTOL1 OTOG F5 F3 F2
2 collagen-containing extracellular matrix GO:0062023 9.55 SERPINC1 F3 F2 COCH APOH
3 extracellular space GO:0005615 9.36 SERPINC1 OTOL1 OTOG F5 F3 F2

Biological processes related to Peripheral Vertigo according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.56 SERPINC1 F5 F3 F2
2 blood coagulation, intrinsic pathway GO:0007597 9.51 F2 APOH
3 water transport GO:0006833 9.49 AVP AQP2
4 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.48 KCNE3 KCNE1
5 positive regulation of blood coagulation GO:0030194 9.46 F2 APOH
6 potassium ion export across plasma membrane GO:0097623 9.43 KCNE3 KCNE1
7 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.4 KCNE3 KCNE1
8 negative regulation of fibrinolysis GO:0051918 9.37 F2 APOH
9 regulation of blood coagulation GO:0030193 9.33 SERPINC1 F2 APOH
10 membrane repolarization during action potential GO:0086011 9.32 KCNE3 KCNE1
11 hemostasis GO:0007599 9.26 SERPINC1 F5 F3 F2
12 sensory perception of sound GO:0007605 9.02 SLC26A4 OTOG KCNE1 GJB2 COCH

Molecular functions related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 8.62 KCNE3 KCNE1
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Sources for Peripheral Vertigo

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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