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MCID: PRP028
MIFTS: 39

Peripheral Vertigo

Categories: Ear diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Peripheral Vertigo

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MalaCards integrated aliases for Peripheral Vertigo:

Name: Peripheral Vertigo 12 15
Vertigo, Peripheral 73

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9847
ICD9CM 35 386.1 386.19
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Summaries for Peripheral Vertigo

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MalaCards based summary : Peripheral Vertigo, also known as vertigo, peripheral, is related to prothrombin deficiency and acquired angioedema, and has symptoms including vertigo An important gene associated with Peripheral Vertigo is COCH (Cochlin), and among its related pathways/superpathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). The drugs Piracetam and Histamine have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, liver and heart, and related phenotypes are homeostasis/metabolism and nervous system

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Related Diseases for Peripheral Vertigo

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Diseases related to Peripheral Vertigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 prothrombin deficiency 10.3 F2 F3
2 acquired angioedema 10.3 CRP F5
3 may-thurner syndrome 10.3 APOH F5
4 acquired hemophilia 10.3 F3 F5
5 acquired hemophilia a 10.3 F3 F5
6 hemophilia 10.3 F2 F3
7 acanthamoeba keratitis 10.3 APOH F5
8 malignant otitis externa 10.3 CRP F2
9 heparin-induced thrombocytopenia 10.3 F3 SERPINC1
10 pregnancy loss, recurrent 1 10.3 APOH F5
11 cerebral falx meningioma 10.3 F2 F3
12 paracetamol poisoning 10.3 F2 F5
13 mediastinitis 10.3 CRP F5
14 chronic thromboembolic pulmonary hypertension 10.3 CRP F2
15 abdominal tuberculosis 10.3 CRP F2
16 sticky platelet syndrome 10.3 F5 SERPINC1
17 burns 10.3 CRP SERPINC1
18 qualitative platelet defect 10.3 F2 F3
19 japanese spotted fever 10.2 CRP SERPINC1
20 ischemic neuropathy 10.2 CRP F2
21 hemoglobin e disease 10.2 F2 F5
22 femoral neuropathy 10.2 F2 F3
23 alpha-2-plasmin inhibitor deficiency 10.2 F2 SERPINC1
24 intracranial embolism 10.2 F2 SERPINC1
25 alcohol-related birth defect 10.2 F2 F3
26 cryptogenic cirrhosis 10.2 F2 F5
27 multicentric castleman disease 10.2 CRP F3
28 hantavirus pulmonary syndrome 10.2 F2 F3
29 von willebrand disease, type 1 10.2 F2 F3
30 papilledema 10.2 APOH F2
31 factor viii deficiency 10.2 F2 F5
32 anterior cranial fossa meningioma 10.2 F2 F3
33 porencephaly 10.2 F2 F5
34 subendocardial myocardial infarction 10.2 F2 SERPINC1
35 vascular hemostatic disease 10.2 F2 F3
36 catastrophic antiphospholipid syndrome 10.2 APOH F3 F5
37 intermediate coronary syndrome 10.2 CRP F3 SERPINC1
38 splenic disease 10.2 F2 F3
39 endocardium disease 10.2 CRP F2 F3
40 factor xiii deficiency 10.2 F3 F5
41 superior semicircular canal dehiscence 10.2 COCH RTEL1
42 arteritic anterior ischemic optic neuropathy 10.2 CRP F2 F5
43 arteries, anomalies of 10.2 CRP F3 SERPINC1
44 thrombasthenia 10.2 F2 F3 F5
45 legg-calve-perthes disease 10.2 APOH F5 SERPINC1
46 sudden sensorineural hearing loss 10.2 APOH F2 F5
47 leech infestation 10.2 F2 F3 SERPINC1
48 intestinal impaction 10.2 F2 F3 SERPINC1
49 meningococcemia 10.2 F5 SERPINC1
50 infective endocarditis 10.2 APOH CRP F2

Comorbidity relations with Peripheral Vertigo via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease
Labyrinthitis

Graphical network of the top 20 diseases related to Peripheral Vertigo:



Diseases related to Peripheral Vertigo
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Symptoms & Phenotypes for Peripheral Vertigo

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UMLS symptoms related to Peripheral Vertigo:


vertigo

MGI Mouse Phenotypes related to Peripheral Vertigo:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 APOH AQP2 AVP CRP F2 F3
2 nervous system MP:0003631 9.28 AVP CRLF1 F2 F3 F5 KCNE3
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Drugs & Therapeutics for Peripheral Vertigo

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Drugs for Peripheral Vertigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Piracetam Approved, Investigational Phase 4 7491-74-9
2
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6, 75614-87-8 774
3
Dimenhydrinate Approved Phase 4 523-87-5 441281
4
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
5 Antiemetics Phase 4,Phase 3
6 Peripheral Nervous System Agents Phase 4,Phase 3
7 Histamine Antagonists Phase 4,Phase 3
8 Histamine H1 Antagonists Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 Neurotransmitter Agents Phase 4,Phase 3
11 Autonomic Agents Phase 4,Phase 3
12
Promethazine Approved, Investigational Phase 3 60-87-7 4927
13
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
14
Lorazepam Approved Phase 3 846-49-1 3958
15 GABA Modulators Phase 3
16 Central Nervous System Depressants Phase 3
17 Psychotropic Drugs Phase 3
18 Dermatologic Agents Phase 3
19 Anti-Allergic Agents Phase 3
20 Anesthetics, Local Phase 3
21 Anesthetics Phase 3
22 Anti-Anxiety Agents Phase 3
23 Tranquilizing Agents Phase 3
24 Anticonvulsants Phase 3
25 GABA Agents Phase 3
26 Antipruritics Phase 3
27 Hypnotics and Sedatives Phase 3
28
Betahistine Approved, Investigational 5638-76-6 2366
29 Vasodilator Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo Completed NCT01890538 Phase 4 Administration of 100 mg dimenhydrinate intravenous;2 g piracetam intravenous
2 Promethazine vs. Lorazepam for Treatment of Vertigo Completed NCT01827293 Phase 3 Promethazine;Lorazepam
3 Effectiveness of Betaserc® (Betahistine Dihydrochloride) in Patients With Vestibular Vertigo in Routine Practice Completed NCT01759251
4 Diagnosis Of Vertigo With New Imaging Completed NCT00593216
5 Effects of a Vestibular Rehabilitation Maneuver Completed NCT01080430 Not Applicable

Search NIH Clinical Center for Peripheral Vertigo

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Genetic Tests for Peripheral Vertigo

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Anatomical Context for Peripheral Vertigo

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MalaCards organs/tissues related to Peripheral Vertigo:

41
Neutrophil, Liver, Heart, Spinal Cord, Placenta
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Publications for Peripheral Vertigo

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Articles related to Peripheral Vertigo:

(show top 50) (show all 51)
# Title Authors Year
1
Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? ( 30268346 )
2019
2
Peripheral Vertigo. ( 30454774 )
2019
3
Author response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. ( 29335312 )
2018
4
Editors' note: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. ( 29335310 )
2018
5
Reader response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. ( 29335311 )
2018
6
Decompensated labyrinthine weakness presenting as de novo peripheral vertigo: a discrete clinical entity? ( 29343311 )
2018
7
Analysis of Risk Factors in Patients With Peripheral Vertigo or Central Vertigo. ( 29722738 )
2018
8
New Onset Focal Stabbing Headache Associated With Peripheral Vertigo: A Case Report. ( 29034450 )
2018
9
Usage of the HINTS exam and neuroimaging in the assessment of peripheral vertigo in the emergency department. ( 30201056 )
2018
10
Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. ( 28069982 )
2017
11
The impact of opioid medications on subsequent fractures in discharged emergency department patients with peripheral vertigo. ( 28631577 )
2017
12
A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency. ( 29163732 )
2017
13
Effect of a vestibular rehabilitation protocol to improve the health-related quality of life and postural balance in patients with peripheral vertigo. ( 27676762 )
2016
14
THE USEFULNESS OF MONITORING THE NEUTROPHIL TO LYMPHOCYTE RATIO IN PATIENTS WITH PERIPHERAL VERTIGO. ( 27661276 )
2016
15
Anxiety and depression among patients with different types of vestibular peripheral vertigo. ( 25654382 )
2015
16
Use of betahistine in the treatment of peripheral vertigo. ( 26245698 )
2015
17
Associations between peripheral vertigo and gastroesophageal reflux disease. ( 26115947 )
2015
18
Histamine Antagonists for Treatment of Peripheral Vertigo: A Meta-Analysis. ( 26381004 )
2015
19
Outcomes among patients discharged from the emergency department with a diagnosis of peripheral vertigo. ( 26385410 )
2015
20
Neutrophil-to-lymphocyte ratio in patients with peripheral vertigo: A prospective controlled clinical study. ( 25219290 )
2014
21
Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo in the emergency department: A double blind, randomized clinical trial of efficacy and safety. ( 24594499 )
2014
22
Evaluation of the effect of nimodipine o.d. (extended release) vs nimodipine t.i.d. in the treatment of peripheral vertigo. ( 23808594 )
2013
23
Response to: "Cerebellar infarctions mimicking acute peripheral vertigo," from Yeo et al. ( 23633501 )
2013
24
Letter to the editor on "Cerebellar infarctions mimicking acute peripheral vertigo: how to avoid misdiagnosis?". ( 23633500 )
2013
25
Cerebellar infarctions mimicking acute peripheral vertigo: how to avoid misdiagnosis? ( 23307911 )
2013
26
Comparison of the effectiveness of intravenous piracetam and intravenous dimenhydrinate in the treatment of acute peripheral vertigo in the emergency department. ( 24276103 )
2013
27
An easy diagnostic tool distinguishing lateral medullary infarction from peripheral vertigo. ( 21855212 )
2012
28
Medullary infarction after vertebral artery dissection presenting as acute peripheral vertigo. ( 21307810 )
2011
29
Sonographic examination of epiaortic vessels in patients with peripheral vertigo. ( 23396499 )
2010
30
Stiff-person syndrome with acute recurrent peripheral vertigo: possible evidence of gamma aminobutyric acid as a neurotransmitter in the vestibular periphery. ( 17666138 )
2008
31
Is surgical vestibular ablation necessary in disabling peripheral vertigo? ( 23120494 )
2008
32
Role of C-reactive protein, D-dimer, and fibrinogen levels in the differential diagnosis of central and peripheral vertigo. ( 18029334 )
2007
33
Intracranial vertebral artery dissection mimicking acute peripheral vertigo. ( 16428195 )
2006
34
Surgical treatment of peripheral vertigo and vertiginous diseases. ( 15637415 )
2005
35
Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigo. ( 15474112 )
2004
36
Relevance of plasma D-dimer measurement in patients with acute peripheral vertigo. ( 12818056 )
2003
37
Acute peripheral vertigo: involvement of the hemostatic system. ( 15106288 )
2003
38
Intramuscular droperidol versus intramuscular dimenhydrinate for the treatment of acute peripheral vertigo in the emergency department: a randomized clinical trial. ( 12045085 )
2002
39
New approaches to the management of peripheral vertigo: efficacy and safety of two calcium antagonists in a 12-week, multinational, double-blind study. ( 11981396 )
2002
40
A study on peripheral vertigo in a Kolkata based hospital. ( 23119868 )
2002
41
Posterior fossa vestibular nerve section for the management of peripheral vertigo. ( 10392296 )
1999
42
Droperidol for the treatment of acute peripheral vertigo. ( 9928721 )
1999
43
3D analysis of nystagmus in peripheral vertigo. ( 9105433 )
1997
44
Overall view and rationale for surgical alternatives for incapacitating peripheral vertigo. ( 8022608 )
1994
45
Surgical treatment of incapacitating peripheral vertigo. Criteria for the evaluation of surgical results. ( 8022609 )
1994
46
Transdermal scopolamine for peripheral vertigo (a double-blind study). ( 3894551 )
1985
47
Peripheral vertigo. ( 3979333 )
1985
48
The causes of peripheral vertigo. ( 6499708 )
1984
49
Peripheral vertigo. ( 6499706 )
1984
50
Complications of treatment of peripheral vertigo. ( 6149924 )
1984
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Variations for Peripheral Vertigo

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Expression for Peripheral Vertigo

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Search GEO for disease gene expression data for Peripheral Vertigo.
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Pathways for Peripheral Vertigo

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Pathways related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Collagen chain trimerization 66
Show member pathways
 12.28 F2 F3 F5 KCNE3 SERPINC1
2
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 11.46 F2 F3 F5 SERPINC1
3
Complement and coagulation cascades 1 37
11.07 F2 F3 F5 SERPINC1
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GO Terms for Peripheral Vertigo

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Cellular components related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 APOH AVP COCH CRLF1 CRP F2
2 collagen-containing extracellular matrix GO:0062023 9.46 APOH COCH F3 SERPINC1
3 extracellular space GO:0005615 9.32 APOH AVP COCH CRLF1 CRP F2

Biological processes related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.46 F2 F3 F5 SERPINC1
2 water transport GO:0006833 9.4 AQP2 AVP
3 blood coagulation, intrinsic pathway GO:0007597 9.37 APOH F2
4 positive regulation of blood coagulation GO:0030194 9.32 APOH F2
5 negative regulation of fibrinolysis GO:0051918 9.26 APOH F2
6 regulation of blood coagulation GO:0030193 9.13 APOH F2 SERPINC1
7 hemostasis GO:0007599 8.92 F2 F3 F5 SERPINC1

Molecular functions related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1
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Sources for Peripheral Vertigo

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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