Aliases & Classifications for Peripheral Vertigo

MalaCards integrated aliases for Peripheral Vertigo:

Name: Peripheral Vertigo 12 15
Vertigo, Peripheral 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9847
ICD9CM 34 386.19
ICD10 32 H81.399
UMLS 71 C0029706 C0155501

Summaries for Peripheral Vertigo

MalaCards based summary : Peripheral Vertigo, also known as vertigo, peripheral, is related to benign paroxysmal positional nystagmus and vestibular neuronitis, and has symptoms including vertigo An important gene associated with Peripheral Vertigo is CRP (C-Reactive Protein), and among its related pathways/superpathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). The drugs Histamine and Dimenhydrinate have been mentioned in the context of this disorder. Affiliated tissues include testes, neutrophil and eye, and related phenotype is nervous system.

Related Diseases for Peripheral Vertigo

Diseases related to Peripheral Vertigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 benign paroxysmal positional nystagmus 30.8 RTEL1 OTOL1 OTOG
2 vestibular neuronitis 30.6 SDSL RTEL1 OTOL1 CRLF1
3 arachnoiditis 30.4 CRP CRLF1
4 labyrinthitis 30.4 SLC26A4 GJB2 CRLF1
5 meniere disease 30.2 RTEL1 FAM136A DTNA COCH AQP2
6 thrombophilia due to activated protein c resistance 30.2 SERPINC1 F5 F3 F2 APOH
7 inner ear disease 30.0 SLC26A4 RTEL1 GJB2 COCH
8 vestibular disease 27.0 SLC26A4 SDSL RTEL1 OTOL1 OTOG KCNE3
9 arteritic anterior ischemic optic neuropathy 10.7 F5 F2
10 orbital osteomyelitis 10.6 F2 CRP
11 small intestine diverticulitis 10.6 F2 CRP
12 may-thurner syndrome 10.6 F5 APOH
13 paracetamol poisoning 10.6 F5 F2
14 acanthamoeba keratitis 10.6 F5 APOH
15 acquired angioedema 10.6 F5 CRP
16 papillary adenofibroma 10.6 F3 F2
17 acquired hemophilia 10.6 F5 F3
18 acquired hemophilia a 10.6 F5 F3
19 femoral neuropathy 10.6 F3 F2
20 heparin-induced thrombocytopenia 10.6 SERPINC1 F3
21 hemopneumothorax 10.6 F3 F2
22 ascending cholangitis 10.6 F2 CRP
23 gastric hemangioma 10.6 F3 F2
24 sticky platelet syndrome 10.6 SERPINC1 F5
25 qualitative platelet defect 10.6 F3 F2
26 puerperal pulmonary embolism 10.6 SERPINC1 APOH
27 achenbach syndrome 10.6 F3 F2 CRP
28 splenic abscess 10.6 F2 CRP
29 synovial angioma 10.5 F3 F2 CRP
30 renal pelvis squamous cell carcinoma 10.5 F3 F2 CRP
31 emphysematous cholecystitis 10.5 F3 F2 CRP
32 critical illness polyneuropathy 10.5 F3 CRP
33 cryptogenic cirrhosis 10.5 F5 F2
34 ankylosing spondylitis 1 10.5 F3 F2 CRP
35 epidural abscess 10.5 F3 F2 CRP
36 hemopericardium 10.5 F3 F2
37 acalculous cholecystitis 10.5 F2 CRP
38 active peptic ulcer disease 10.5 F3 F2 CRP
39 fournier gangrene 10.5 SERPINC1 F3 F2
40 cholesterol embolism 10.5 SERPINC1 F2 CRP
41 abducens nerve disease 10.5 SERPINC1 F2 CRP
42 lateral sinus thrombosis 10.5 SERPINC1 F3 F2
43 anuria 10.5 F3 F2 CRP
44 cardiac tamponade 10.5 F3 F2 CRP
45 branch retinal artery occlusion 10.5 SERPINC1 F2 CRP
46 giant hemangioma 10.5 SERPINC1 F3 F2
47 dic in newborn 10.5 SERPINC1 F3 F2
48 mastoiditis 10.5 SERPINC1 F2 CRP
49 waterhouse-friderichsen syndrome 10.5 SERPINC1 F3 F2
50 tricuspid valve insufficiency 10.5 F3 F2 CRP

Comorbidity relations with Peripheral Vertigo via Phenotypic Disease Network (PDN):


Hypertension, Essential Labyrinthitis

Graphical network of the top 20 diseases related to Peripheral Vertigo:



Diseases related to Peripheral Vertigo

Symptoms & Phenotypes for Peripheral Vertigo

UMLS symptoms related to Peripheral Vertigo:


vertigo

MGI Mouse Phenotypes related to Peripheral Vertigo:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.4 AVP CRLF1 DTNA F2 F3 F5

Drugs & Therapeutics for Peripheral Vertigo

Drugs for Peripheral Vertigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6 774
2
Dimenhydrinate Approved Phase 4 523-87-5 441281
3
Piracetam Approved, Investigational Phase 4 7491-74-9
4 Gastrointestinal Agents Phase 4
5 Antiemetics Phase 4
6 Histamine Antagonists Phase 4
7 Histamine H1 Antagonists Phase 4
8
Histamine Phosphate Phase 4 51-74-1 65513
9 Neurotransmitter Agents Phase 4
10
Meclizine Approved Phase 3 569-65-3 4034
11
Promethazine Approved, Investigational Phase 3 60-87-7 4927
12
Lorazepam Approved Phase 3 846-49-1 3958
13
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
14
Cilostazol Approved, Investigational Phase 3 73963-72-1 2754
15 Anesthetics Phase 3
16 Hypnotics and Sedatives Phase 3
17 Anti-Allergic Agents Phase 3
18 Anti-Anxiety Agents Phase 3
19 Psychotropic Drugs Phase 3
20 Dermatologic Agents Phase 3
21 Anesthetics, Local Phase 3
22 Anticonvulsants Phase 3
23 GABA Modulators Phase 3
24 Neuroprotective Agents Phase 3
25 Protective Agents Phase 3
26 Respiratory System Agents Phase 3
27 Phosphodiesterase Inhibitors Phase 3
28 Fibrinolytic Agents Phase 3
29 Phosphodiesterase 3 Inhibitors Phase 3
30 Platelet Aggregation Inhibitors Phase 3
31 Vasodilator Agents Phase 3
32 Anti-Asthmatic Agents Phase 3
33 Bronchodilator Agents Phase 3
34 Ginkgo Phase 3
35
Betahistine Approved, Investigational Phase 2 5638-76-6 2366
36 Pharmaceutical Solutions Phase 2
37 Hemostatics
38 Vasoconstrictor Agents
39 Vasopressins
40 Coagulants
41 Arginine Vasopressin
42
Arginine Investigational, Nutraceutical 74-79-3 6322

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo: A Double Blind Randomized Clinical Trial Completed NCT01890538 Phase 4 Administration of 100 mg dimenhydrinate intravenous;2 g piracetam intravenous
2 " National, Phase III, Radomized, Double-Blind, Double -Dummy, Controlled, Parallel to Evaluate Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) Soft Gel Capsules in the Control of Acute Vertigo Symphtoms From Peripheral Origin" Unknown status NCT02112578 Phase 3 Meclizine;Dimenhydrinate
3 Promethazine vs. Lorazepam for Treatment of Vertigo in the Emergency Department: A Randomized Clinical Trial Completed NCT01827293 Phase 3 Promethazine;Lorazepam
4 A Single-center, Prospective, Randomized, Parallel Group, Placebo-controlled Exploratory Study on the Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3 Renexin (cilostazol 100mg + gingko biloba extract 80 mg);Placebo
5 Multicenter Randomized Controlled Phase 2 Trial to Evaluate AM-125 in the Treatment of Acute Peripheral Vertigo Following Neurosurgery (TRAVERS) Recruiting NCT03908567 Phase 2 Intranasal Drug;Oral Tablet
6 Evaluation of Thiol/Disulfide Homeostasis and Ischemia Modified Albumin Levels in the Differential Diagnosis of Central and Peripheral Vertigo Completed NCT04070664
7 Value of Copeptin and the S-100b Protein Assay in Ruling Out the Diagnosis of Stroke-induced Dizziness Pattern in Emergency Departments Completed NCT03974464
8 Effect of the Cranial Osteopathic Techniques on the Symptoms of Benign Paroxysmal Positional Vertigo Completed NCT03854084
9 Virtual Reality Epley Maneuver System (VREMS) for Treatment of Benign Paroxysmal Positional Vertigo Not yet recruiting NCT04436783

Search NIH Clinical Center for Peripheral Vertigo

Genetic Tests for Peripheral Vertigo

Anatomical Context for Peripheral Vertigo

MalaCards organs/tissues related to Peripheral Vertigo:

40
Testes, Neutrophil, Eye, Bone, Brain, Heart, Thyroid

Publications for Peripheral Vertigo

Articles related to Peripheral Vertigo:

(show top 50) (show all 229)
# Title Authors PMID Year
1
Is drug consumption correlated with benign paroxysmal positional vertigo (BPPV) recurrence? 61
32078026 2020
2
Association of Cervical Spondylosis With Peripheral Vertigo: A Case-Control Study. 61
32396217 2020
3
Rituximab in the treatment of Susac's syndrome: Report of a case. 61
32380850 2020
4
Role of inferior colliculus in vestibular vertigo induced by water caloric irrigation. 61
32401101 2020
5
Effects of Peripheral Vertigo on Inflammatory and Immunologic Laboratory Markers. 61
32339050 2020
6
Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]. 61
32129465 2020
7
Diagnostic Value of Serum Biomarkers for Differentiating Central and Peripheral Causes of Acute Vertigo. 61
32266274 2020
8
Benign Paroxysmal Positional Vertigo and Occult Subarachnoid Hemorrhage Complicated after Head Trauma. 61
32292484 2020
9
Prevalence and Risk Factors of White Matter Lesions in Tibetan Patients Without Acute Stroke. 61
31679502 2020
10
Determination of Anxiety, Health Anxiety and Somatosensory Amplification Levels in Individuals with Benign Paroxysmal Positional Vertigo. 61
31347508 2019
11
Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: A case-control study and meta-analysis. 61
31521916 2019
12
Cinnarizine/betahistine combination vs. the respective monotherapies in acute peripheral vertigo: a randomized triple-blind placebo-controlled trial. 61
31420703 2019
13
Management of peripheral vertigo with antihistamines: New options on the horizon. 61
31269270 2019
14
Recovery of ocular and cervical vestibular evoked myogenic potentials after treatment of inner ear diseases. 61
31070081 2019
15
[How to initially screen common central "malignant vertigo" at the bedside?] 61
31434383 2019
16
A Case of Isolated Nodular Infarction Mimicking Vestibular Neuritis on the Contralateral Side. 61
31234246 2019
17
Safety and predictors of stroke mimics in The Norwegian Tenecteplase Stroke Trial (NOR-TEST). 61
30019629 2019
18
Effects of vestibular rehabilitation, with or without betahistine, on managing residual dizziness after successful repositioning manoeuvres in patients with benign paroxysmal positional vertigo: a protocol for a randomised controlled trial. 61
31217316 2019
19
Identification of Factors Related to Cases of Benign Paroxysmal Positional Vertigo Refractory to Canalicular Repositioning Maneuvers and Evaluation of the Need for Magnetic Resonance Imaging in their Management: Retrospective Analysis of a Series of 176 Cases. 61
30956705 2019
20
Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study. 61
30837524 2019
21
Neurologic manifestations of elderly patients with cancer. 61
29704209 2019
22
Peripheral Vertigo. 61
30454774 2019
23
Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? 61
30268346 2019
24
Oral Piracetam vs Betahistine in Outpatient Management of Peripheral Vertigo; a Randomized Clinical Trial. 61
30847444 2019
25
Innovative Use of Google Cardboard in Clinical Examination of Patients of Vertigo. 61
31673230 2019
26
Misdiagnosis of acute ischemic stroke in young patients. 61
31048273 2019
27
Long-term outcomes of triple semicircular canal plugging for the treatment of intractable Meniere's disease: A single center experience of 361 cases. 61
31640108 2019
28
[Suppression head impulse paradigm in healthy adult population: the values and features of the parameters]. 61
30585003 2018
29
Nimodipine for the treatment of otolaryngic indications. 61
30190294 2018
30
Usage of the HINTS exam and neuroimaging in the assessment of peripheral vertigo in the emergency department. 61
30201056 2018
31
Physical therapy in the emergency department: A new opportunity for collaborative care. 61
29853343 2018
32
Efficacy of particle repositioning manoeuvres in benign positional paroxysmal vertigo: A revision of 176 cases treated in a tertiary care centre. 61
28965618 2018
33
Utility of Neutrophil-to-Lymphocyte Ratio (NLR) as a Predictor of Acute Infarction in New-Onset Acute Vertigo Patients Without Neurologic and Computed Tomography Abnormalities. 61
29398242 2018
34
Analysis of Risk Factors in Patients With Peripheral Vertigo or Central Vertigo. 61
29722738 2018
35
Referral patterns from emergency department to otolaryngology clinic. 61
29152746 2018
36
Central vertigo. 61
29084063 2018
37
Decompensated labyrinthine weakness presenting as de novo peripheral vertigo: a discrete clinical entity? 61
29343311 2018
38
Assessment of the effect of mesoglycan in the treatment of audiovestibular disorders of vascular origin. 61
29734824 2018
39
[Stroke mimicking acute peripheral vertigo: how to avoid misdiagnosis - importance of alarm symptoms and assessment of eye movements]. 61
29623865 2018
40
[Approach to patients with vertigo]. 61
30504108 2018
41
Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication. 61
30079052 2018
42
The impact of opioid medications on subsequent fractures in discharged emergency department patients with peripheral vertigo. 61
28631577 2018
43
Threat of a Cycle Proof: Vertebral Artery Dissection Associated with Posterior Inferior Cerebellar Artery Infarction. 61
30687555 2018
44
[The diagnostic significance of vestibular evoked myogenic potentials in different types of vertigo]. 61
29460899 2018
45
New Onset Focal Stabbing Headache Associated With Peripheral Vertigo: A Case Report. 61
29034450 2018
46
Author response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. 61
29335312 2018
47
Reader response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. 61
29335311 2018
48
A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency. 61
29163732 2017
49
Health-related quality of life and disability in patients with acute unilateral peripheral vestibular disorders. 61
27595924 2017
50
Advances in the diagnosis and treatment of benign paroxysmal positional vertigo. 61
28962176 2017

Variations for Peripheral Vertigo

Expression for Peripheral Vertigo

Search GEO for disease gene expression data for Peripheral Vertigo.

Pathways for Peripheral Vertigo

Pathways related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 SERPINC1 KCNE3 F5 F3 F2
2
Show member pathways
11.46 SERPINC1 F5 F3 F2
3 11.09 SERPINC1 F5 F3 F2

GO Terms for Peripheral Vertigo

Cellular components related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 SERPINC1 OTOL1 OTOG F5 F3 F2
2 collagen-containing extracellular matrix GO:0062023 9.55 SERPINC1 F3 F2 COCH APOH
3 extracellular space GO:0005615 9.36 SERPINC1 OTOL1 OTOG F5 F3 F2

Biological processes related to Peripheral Vertigo according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.56 SERPINC1 F5 F3 F2
2 ventricular cardiac muscle cell action potential GO:0086005 9.52 KCNE3 KCNE1
3 blood coagulation, intrinsic pathway GO:0007597 9.51 F2 APOH
4 water transport GO:0006833 9.49 AVP AQP2
5 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.48 KCNE3 KCNE1
6 potassium ion export across plasma membrane GO:0097623 9.46 KCNE3 KCNE1
7 positive regulation of blood coagulation GO:0030194 9.43 F2 APOH
8 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.4 KCNE3 KCNE1
9 negative regulation of fibrinolysis GO:0051918 9.37 F2 APOH
10 sensory perception of sound GO:0007605 9.35 SLC26A4 OTOG KCNE1 GJB2 COCH
11 regulation of blood coagulation GO:0030193 9.33 SERPINC1 F2 APOH
12 membrane repolarization during action potential GO:0086011 9.32 KCNE3 KCNE1
13 hemostasis GO:0007599 8.92 SERPINC1 F5 F3 F2

Molecular functions related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 8.62 KCNE3 KCNE1

Sources for Peripheral Vertigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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