Aliases & Classifications for Peripheral Vertigo

MalaCards integrated aliases for Peripheral Vertigo:

Name: Peripheral Vertigo 12 15
Vertigo, Peripheral 72

Classifications:



External Ids:

Disease Ontology 12 DOID:9847
ICD9CM 35 386.1 386.19
UMLS 72 C0029706 C0155501

Summaries for Peripheral Vertigo

MalaCards based summary : Peripheral Vertigo, also known as vertigo, peripheral, is related to meniere disease and vestibular neuronitis, and has symptoms including vertigo An important gene associated with Peripheral Vertigo is COCH (Cochlin), and among its related pathways/superpathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). The drugs Dimenhydrinate and Antiemetics have been mentioned in the context of this disorder. Affiliated tissues include testes, neutrophil and brain, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Peripheral Vertigo

Diseases related to Peripheral Vertigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 meniere disease 30.3 FAM136A COCH AQP2
2 vestibular neuronitis 30.1 SALL1 RTEL1 CACNA1A
3 thrombophilia due to activated protein c resistance 29.8 SERPINC1 F5 F3 F2 APOH
4 inner ear disease 29.4 SLC26A4 RTEL1 COCH
5 vestibular disease 26.6 SLC26A4 RTEL1 KCNE3 FAM136A CRLF1 COCH
6 prothrombin deficiency 10.8 F3 F2
7 may-thurner syndrome 10.7 F5 APOH
8 malignant otitis externa 10.7 F2 CRP
9 acanthamoeba keratitis 10.7 F5 APOH
10 chronic thromboembolic pulmonary hypertension 10.7 F2 CRP
11 paracetamol poisoning 10.7 F5 F2
12 cerebral falx meningioma 10.7 F3 F2
13 abdominal tuberculosis 10.7 F2 CRP
14 acquired angioedema 10.7 F5 CRP
15 pregnancy loss, recurrent 1 10.7 F5 APOH
16 acquired hemophilia 10.7 F5 F3
17 acquired hemophilia a 10.7 F5 F3
18 hemoglobin e disease 10.6 F5 F2
19 ischemic neuropathy 10.6 F2 CRP
20 heparin-induced thrombocytopenia 10.6 SERPINC1 F3
21 qualitative platelet defect 10.6 F3 F2
22 mediastinitis 10.6 F5 CRP
23 intracranial embolism 10.6 SERPINC1 F2
24 femoral neuropathy 10.6 F3 F2
25 sticky platelet syndrome 10.6 SERPINC1 F5
26 papilledema 10.6 F2 APOH
27 alpha-2-plasmin inhibitor deficiency 10.6 SERPINC1 F2
28 cryptogenic cirrhosis 10.6 F5 F2
29 japanese spotted fever 10.6 SERPINC1 CRP
30 hantavirus pulmonary syndrome 10.6 F3 F2
31 alcohol-related birth defect 10.6 F3 F2
32 von willebrand disease, type 1 10.5 F3 F2
33 infective endocarditis 10.5 F2 CRP APOH
34 sudden sensorineural hearing loss 10.5 F5 F2 APOH
35 anterior cranial fossa meningioma 10.5 F3 F2
36 superior semicircular canal dehiscence 10.5 RTEL1 COCH
37 subendocardial myocardial infarction 10.5 SERPINC1 F2
38 endocardium disease 10.5 F3 F2 CRP
39 catastrophic antiphospholipid syndrome 10.5 F5 F3 APOH
40 sneddon syndrome 10.5 SERPINC1 F2 APOH
41 porencephaly 10.5 F5 F2
42 livedoid vasculitis 10.5 SERPINC1 F2 APOH
43 arteritic anterior ischemic optic neuropathy 10.5 F5 F2 CRP
44 factor viii deficiency 10.5 F5 F2
45 fournier gangrene 10.5 SERPINC1 F3 F2
46 intestinal impaction 10.5 SERPINC1 F3 F2
47 leech infestation 10.5 SERPINC1 F3 F2
48 giant hemangioma 10.5 SERPINC1 F3 F2
49 intermediate coronary syndrome 10.5 SERPINC1 F3 CRP
50 paralytic ileus 10.5 CRP AVP

Comorbidity relations with Peripheral Vertigo via Phenotypic Disease Network (PDN):


Hypertension, Essential Labyrinthitis

Graphical network of the top 20 diseases related to Peripheral Vertigo:



Diseases related to Peripheral Vertigo

Symptoms & Phenotypes for Peripheral Vertigo

UMLS symptoms related to Peripheral Vertigo:


vertigo

MGI Mouse Phenotypes related to Peripheral Vertigo:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 APOH AQP2 AVP CACNA1A CRP F2
2 behavior/neurological MP:0005386 10.02 AQP2 AVP CACNA1A CRLF1 F2 F3
3 cardiovascular system MP:0005385 9.92 CRP F2 F3 F5 KCNE3 RTEL1
4 mortality/aging MP:0010768 9.9 APOH AQP2 AVP CACNA1A CRLF1 F2
5 nervous system MP:0003631 9.7 AVP CACNA1A CRLF1 F2 F3 F5
6 normal MP:0002873 9.17 AVP CACNA1A COCH F2 F3 RTEL1

Drugs & Therapeutics for Peripheral Vertigo

Drugs for Peripheral Vertigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dimenhydrinate Approved Phase 4 523-87-5 441281
2 Antiemetics Phase 4
3 Gastrointestinal Agents Phase 4
4 Histamine H1 Antagonists Phase 4
5 Histamine Antagonists Phase 4
6
Histamine Approved, Investigational Phase 3 51-45-6 774
7
Meclizine Approved Phase 3 569-65-3 4034
8
Promethazine Approved, Investigational Phase 3 60-87-7 4927
9
Lorazepam Approved Phase 3 846-49-1 3958
10
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
11
Cilostazol Approved, Investigational Phase 3 73963-72-1 2754
12 Neurotransmitter Agents Phase 3
13
Histamine Phosphate Phase 3 51-74-1 65513
14 Anti-Allergic Agents Phase 3
15 Anesthetics, Local Phase 3
16 Tranquilizing Agents Phase 3
17 Central Nervous System Depressants Phase 3
18 Anti-Anxiety Agents Phase 3
19 GABA Agents Phase 3
20 Hypnotics and Sedatives Phase 3
21 GABA Modulators Phase 3
22 Psychotropic Drugs Phase 3
23 Dermatologic Agents Phase 3
24 Anesthetics Phase 3
25 Antipruritics Phase 3
26 Anticonvulsants Phase 3
27 Peripheral Nervous System Agents Phase 3
28 Autonomic Agents Phase 3
29 Vasodilator Agents Phase 3
30 Respiratory System Agents Phase 3
31 Fibrinolytic Agents Phase 3
32 Ginkgo Phase 3
33 Neuroprotective Agents Phase 3
34 Phosphodiesterase Inhibitors Phase 3
35 Protective Agents Phase 3
36 Platelet Aggregation Inhibitors Phase 3
37 Anti-Asthmatic Agents Phase 3
38 Bronchodilator Agents Phase 3
39 Phosphodiesterase 3 Inhibitors Phase 3
40
Betahistine Approved, Investigational Phase 2 5638-76-6 2366
41 Pharmaceutical Solutions Phase 2
42 Coagulants
43 Natriuretic Agents
44 Hemostatics
45 Vasopressins
46 arginine
47 Vasoconstrictor Agents
48 Arginine Vasopressin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo: A Double Blind Randomized Clinical Trial Completed NCT01890538 Phase 4 Administration of 100 mg dimenhydrinate intravenous;2 g piracetam intravenous
2 " National, Phase III, Radomized, Double-Blind, Double -Dummy, Controlled, Parallel to Evaluate Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) Soft Gel Capsules in the Control of Acute Vertigo Symphtoms From Peripheral Origin" Unknown status NCT02112578 Phase 3 Meclizine;Dimenhydrinate
3 Promethazine vs. Lorazepam for Treatment of Vertigo in the Emergency Department: A Randomized Clinical Trial Completed NCT01827293 Phase 3 Promethazine;Lorazepam
4 A Single-center, Prospective, Randomized, Parallel Group, Placebo-controlled Exploratory Study on the Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3 Renexin (cilostazol 100mg + gingko biloba extract 80 mg);Placebo
5 Multicenter Randomized Controlled Phase 2 Trial to Evaluate AM-125 in the Treatment of Acute Peripheral Vertigo Following Vestibular Schwannoma Resection (TRAVERS) Not yet recruiting NCT03908567 Phase 2 Intranasal Drug;Oral Tablet
6 Value of Copeptin and the S-100b Protein Assay in Ruling Out the Diagnosis of Stroke-induced Dizziness Pattern in Emergency Departments Completed NCT03974464
7 Effect of the Cranial Osteopathic Techniques on the Symptoms of Benign Paroxysmal Positional Vertigo Completed NCT03854084

Search NIH Clinical Center for Peripheral Vertigo

Genetic Tests for Peripheral Vertigo

Anatomical Context for Peripheral Vertigo

MalaCards organs/tissues related to Peripheral Vertigo:

41
Testes, Neutrophil, Brain, Heart, Skin, Bone, Eye

Publications for Peripheral Vertigo

Articles related to Peripheral Vertigo:

(show top 50) (show all 218)
# Title Authors PMID Year
1
Recovery of ocular and cervical vestibular evoked myogenic potentials after treatment of inner ear diseases. 38
31070081 2019
2
[How to initially screen common central "malignant vertigo" at the bedside?] 38
31434383 2019
3
Cinnarizine/betahistine combination vs. the respective monotherapies in acute peripheral vertigo: a randomized triple-blind placebo-controlled trial. 38
31420703 2019
4
Management of peripheral vertigo with antihistamines: New options on the horizon. 38
31269270 2019
5
Safety and predictors of stroke mimics in The Norwegian Tenecteplase Stroke Trial (NOR-TEST). 38
30019629 2019
6
Determination of Anxiety, Health Anxiety and Somatosensory Amplification Levels in Individuals with Benign Paroxysmal Positional Vertigo. 38
31347508 2019
7
A Case of Isolated Nodular Infarction Mimicking Vestibular Neuritis on the Contralateral Side. 38
31234246 2019
8
Effects of vestibular rehabilitation, with or without betahistine, on managing residual dizziness after successful repositioning manoeuvres in patients with benign paroxysmal positional vertigo: a protocol for a randomised controlled trial. 38
31217316 2019
9
Identification of Factors Related to Cases of Benign Paroxysmal Positional Vertigo Refractory to Canalicular Repositioning Maneuvers and Evaluation of the Need for Magnetic Resonance Imaging in their Management: Retrospective Analysis of a Series of 176 Cases. 38
30956705 2019
10
Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study. 38
30837524 2019
11
Neurologic manifestations of elderly patients with cancer. 38
29704209 2019
12
Peripheral Vertigo. 38
30454774 2019
13
Misdiagnosis of acute ischemic stroke in young patients. 38
31048273 2019
14
Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? 38
30268346 2019
15
Oral Piracetam vs Betahistine in Outpatient Management of Peripheral Vertigo; a Randomized Clinical Trial. 38
30847444 2019
16
[Suppression head impulse paradigm in healthy adult population: the values and features of the parameters]. 38
30585003 2018
17
Nimodipine for the treatment of otolaryngic indications. 38
30190294 2018
18
Usage of the HINTS exam and neuroimaging in the assessment of peripheral vertigo in the emergency department. 38
30201056 2018
19
Physical therapy in the emergency department: A new opportunity for collaborative care. 38
29853343 2018
20
Efficacy of particle repositioning manoeuvres in benign positional paroxysmal vertigo: A revision of 176 cases treated in a tertiary care centre. 38
28965618 2018
21
Utility of Neutrophil-to-Lymphocyte Ratio (NLR) as a Predictor of Acute Infarction in New-Onset Acute Vertigo Patients Without Neurologic and Computed Tomography Abnormalities. 38
29398242 2018
22
Analysis of Risk Factors in Patients With Peripheral Vertigo or Central Vertigo. 38
29722738 2018
23
Referral patterns from emergency department to otolaryngology clinic. 38
29152746 2018
24
Central vertigo. 38
29084063 2018
25
Decompensated labyrinthine weakness presenting as de novo peripheral vertigo: a discrete clinical entity? 38
29343311 2018
26
Assessment of the effect of mesoglycan in the treatment of audiovestibular disorders of vascular origin. 38
29734824 2018
27
[Stroke mimicking acute peripheral vertigo: how to avoid misdiagnosis - importance of alarm symptoms and assessment of eye movements]. 38
29623865 2018
28
[Approach to patients with vertigo]. 38
30504108 2018
29
The impact of opioid medications on subsequent fractures in discharged emergency department patients with peripheral vertigo. 38
28631577 2018
30
Threat of a Cycle Proof: Vertebral Artery Dissection Associated with Posterior Inferior Cerebellar Artery Infarction. 38
30687555 2018
31
Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication. 38
30079052 2018
32
[The diagnostic significance of vestibular evoked myogenic potentials in different types of vertigo]. 38
29460899 2018
33
New Onset Focal Stabbing Headache Associated With Peripheral Vertigo: A Case Report. 38
29034450 2018
34
Editors' note: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. 38
29335310 2018
35
Reader response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. 38
29335311 2018
36
Author response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. 38
29335312 2018
37
A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency. 38
29163732 2017
38
Health-related quality of life and disability in patients with acute unilateral peripheral vestibular disorders. 38
27595924 2017
39
Advances in the diagnosis and treatment of benign paroxysmal positional vertigo. 38
28962176 2017
40
A safe-repositioning maneuver for the management of benign paroxysmal positional vertigo: Gans vs. Epley maneuver; a randomized comparative clinical trial. 38
27488837 2017
41
Italian survey on benign paroxysmal positional vertigo. 38
28872163 2017
42
Isolated transient vertigo: posterior circulation ischemia or benign origin? 38
28615008 2017
43
Diagnostic value of repeated Dix-Hallpike and roll maneuvers in benign paroxysmal positional vertigo. 38
27170347 2017
44
[The diagnosis, treatment and aviation medicine identification of vestibular neuronitis]. 38
29871338 2017
45
Classification, diagnostic criteria and management of benign paroxysmal positional vertigo. 38
27174206 2017
46
Age-Related Increases in Benign Paroxysmal Positional Vertigo Are Reversed in Women Taking Estrogen Replacement Therapy: A Population-Based Study in Taiwan. 38
29311896 2017
47
Effects of Semont maneuver on benign paroxysmal positional vertigo: a meta-analysis. 38
27683970 2017
48
Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. 38
28069982 2017
49
[Main directions of differential diagnosis optimization and rational treatment of an acute vertigo attack]. 38
28638028 2017
50
Increase in the Admission of Stroke Mimics after Change in Emergency Shifts. 38
28467976 2017

Variations for Peripheral Vertigo

Expression for Peripheral Vertigo

Search GEO for disease gene expression data for Peripheral Vertigo.

Pathways for Peripheral Vertigo

GO Terms for Peripheral Vertigo

Cellular components related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 SERPINC1 F5 F3 F2 CRP CRLF1
2 collagen-containing extracellular matrix GO:0062023 9.46 SERPINC1 F3 COCH APOH
3 extracellular space GO:0005615 9.28 SERPINC1 F5 F3 F2 CRP CRLF1

Biological processes related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.46 SERPINC1 F5 F3 F2
2 water transport GO:0006833 9.4 AVP AQP2
3 blood coagulation, intrinsic pathway GO:0007597 9.37 F2 APOH
4 positive regulation of blood coagulation GO:0030194 9.32 F2 APOH
5 negative regulation of fibrinolysis GO:0051918 9.26 F2 APOH
6 regulation of blood coagulation GO:0030193 9.13 SERPINC1 F2 APOH
7 hemostasis GO:0007599 8.92 SERPINC1 F5 F3 F2

Molecular functions related to Peripheral Vertigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 SERPINC1 F2 APOH

Sources for Peripheral Vertigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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