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MCID: PRT036
MIFTS: 66

Peritonitis

Categories: Endocrine diseases, Gastrointestinal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Peritonitis

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MalaCards integrated aliases for Peritonitis:

Name: Peritonitis 12 77 56 6 45 15 17 74
Retractile Mesenteritis 12 54 74
Sclerosing Mesenteritis 12 54 74
Peritoneal Retractile Mesenteritis 54 74
Acute Generalized Peritonitis 12 74
Primary Bacterial Peritonitis 12 74
Mesenteric Panniculitis 54 74
Idiopathic Sclerosing Mesenteritis 54
Liposclerotic Mesenteritis 54
Mesenteric Lipodystrophy 54
Mesenteric Lipogranuloma 54
Mesenteric Fibromatosis 54
Fibromatosis, Abdominal 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 34


Sources

Summaries for Peritonitis

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NIH Rare Diseases : 54 Sclerosing mesenteritis is one of many terms that describes a spectrum of inflammatory disorders that affect the mesentery. The mesentery is the membrane that anchors the small intestine to the back of the abdominal wall. The condition mostly affects men between their 40s and 60s, but women and children can also be affected. It may result in a variety of symptoms including abdominal pain, nausea and vomiting, constipation or diarrhea, weight loss, and fever. Some people have an abdominal mass. The cause of the condition is poorly understood. Suggested possible causes have included previous abdominal surgery or trauma, autoimmunity, paraneoplastic syndromes, ischemic injury, and infection. Treatment depends on the symptoms in each person and may include the use of glucocorticoids, hormonal therapy (tamoxifen or progesterone), or other medications, either alone or in combination (i.e. glucocorticoids in combination with tamoxifen). Surgery may be needed for an obstruction, if present. Although there are case reports of patients with aggressive disease and fatalities, it appears that the condition usually remains stable or is slowly progessive. In some cases, the condition goes away on its own.

MalaCards based summary : Peritonitis, also known as retractile mesenteritis, is related to primary peritoneal carcinoma and tuberculous peritonitis. An important gene associated with Peritonitis is TMEM67 (Transmembrane Protein 67), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Ertapenem and Mupirocin have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. Peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. The symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output.

Wikipedia : 77 Peritonitis is inflammation of the peritoneum, the lining of the inner wall of the abdomen and cover of... more...

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Related Diseases for Peritonitis

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Diseases related to Peritonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1345)
# Related Disease Score Top Affiliating Genes
1 primary peritoneal carcinoma 34.3 CXCL8 IL10 MUC16
2 tuberculous peritonitis 33.8 ADA ALB CRP MUC16 TNF
3 familial mediterranean fever 33.2 CRP IL1B MEFV TNF
4 appendicitis 32.4 ALB CRP CXCL8 IL10 IL1B IL6
5 systemic onset juvenile idiopathic arthritis 32.3 MEFV TNF
6 endometriosis 31.4 CCL2 CXCL8 IL1B IL6
7 end stage renal failure 31.3 ALB CRP IL6 TNF
8 uremia 30.9 ALB B2M CRP
9 acute pancreatitis 30.6 CRP CXCL8 IL10 IL6
10 fasciitis 30.6 CXCL8 IL6 TNF
11 perinatal necrotizing enterocolitis 30.6 CRP CXCL8 IL1B IL6 TNF
12 kidney disease 30.6 ALB B2M CCL2 CRP IL6 TMEM67
13 endometritis 30.5 IL1B IL6 TNF
14 liver disease 30.5 ALB F2 IL6 TNF
15 echinococcosis 30.5 IL10 IL6 TLR2 TNF
16 alcoholic liver cirrhosis 30.4 ALB CXCL8 F2
17 peptic ulcer disease 30.4 CXCL8 IL10 IL1B TNF
18 colitis 30.4 CXCL8 IL10 IL1B IL6 TNF
19 streptococcal toxic-shock syndrome 30.4 CXCL8 IL6 TNF
20 chronic kidney failure 30.4 ALB B2M CRP ICAM1 IL6
21 bone disease 30.4 B2M IL1B IL6 TNF
22 uremic pruritus 30.4 CRP IL1B IL6
23 atrophic gastritis 30.3 CXCL8 IL1B TNF
24 fascioliasis 30.3 ALB IL10 IL1B
25 portal hypertension 30.3 ALB F2 TNF
26 hydronephrosis 30.3 ALB B2M CCL2
27 peripheral artery disease 30.3 CCL2 CRP IL6
28 neutrophil migration 30.3 CXCL8 ICAM1 ITGAM
29 mycobacterium chelonae 30.3 CXCL8 TLR2
30 temporal arteritis 30.2 CCL2 CRP IL6 TNF
31 hepatic encephalopathy 30.2 ALB F2 IL6 TNF
32 autoimmune disease 30.2 IL10 IL1B IL6 TNF
33 protein-energy malnutrition 30.2 ALB IL6 TNF
34 mycobacterium abscessus 30.2 CXCL8 TLR2 TNF
35 takayasu arteritis 30.2 CRP IL6 TNF
36 peripheral vascular disease 30.2 ALB CRP F2 IL6
37 pelvic inflammatory disease 30.2 CCL2 CRP TLR2
38 duodenal ulcer 30.2 CXCL8 IL1B TNF
39 homocysteinemia 30.1 ALB CRP F2
40 arthritis 30.1 CCL2 CXCL8 IL10 IL1B IL6 TNF
41 thrombocytosis 30.1 CRP F2 IL6
42 haemophilus influenzae 30.1 CXCL8 IL1B TLR2 TNF
43 compartment syndrome 30.1 ALB F2 TNF
44 miliary tuberculosis 30.1 ADA MUC16 TNF
45 spondyloarthropathy 30.1 IL10 IL6 TNF
46 cystitis 30.0 CCL2 CRP CXCL8 IL6 TNF
47 pericardial effusion 30.0 ADA CRP IL6 MUC16
48 purpura 30.0 CRP F2 IL6 TNF
49 abdominal tuberculosis 30.0 ADA ALB CRP F2
50 typhoid fever 30.0 ALB CRP F2 IL1B IL6 TNF

Comorbidity relations with Peritonitis via Phenotypic Disease Network (PDN): (show all 13)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Chronic Kidney Failure Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intestinal Obstruction Intestinal Perforation
Paralytic Ileus Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Peritonitis:



Diseases related to Peritonitis
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Symptoms & Phenotypes for Peritonitis

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GenomeRNAi Phenotypes related to Peritonitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 AQP1 CXCL8 F2 ICAM1 IL10 IL1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 AQP1 CXCL8 F2 ICAM1 IL10 IL1B

MGI Mouse Phenotypes related to Peritonitis:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.31 ADA AQP1 B2M CRP F2 ICAM1
2 homeostasis/metabolism MP:0005376 10.31 ADA ALB AQP1 B2M CRP F2
3 hematopoietic system MP:0005397 10.27 ADA AQP1 B2M F2 ICAM1 IL10
4 cellular MP:0005384 10.26 ADA ALB B2M ICAM1 IL10 IL6
5 growth/size/body region MP:0005378 10.26 ADA AQP1 B2M F2 ICAM1 IL10
6 immune system MP:0005387 10.25 ADA B2M CCL2 CRP F2 ICAM1
7 digestive/alimentary MP:0005381 10.21 ADA ALB B2M F2 ICAM1 IL10
8 endocrine/exocrine gland MP:0005379 10.15 ADA ALB AQP1 B2M ICAM1 IL10
9 mortality/aging MP:0010768 10.07 ADA ALB AQP1 B2M F2 ICAM1
10 integument MP:0010771 10.02 B2M F2 ICAM1 IL10 IL1B IL6
11 liver/biliary system MP:0005370 10.02 ADA ALB B2M IL10 IL6 LBP
12 neoplasm MP:0002006 9.76 ALB B2M ICAM1 IL10 IL1B IL6
13 nervous system MP:0003631 9.7 AQP1 B2M F2 ICAM1 IL10 IL1B
14 skeleton MP:0005390 9.32 ADA AQP1 F2 IL10 IL1B IL6
Sources

Drugs & Therapeutics for Peritonitis

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Drugs for Peritonitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 323)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4,Phase 2 153832-46-3 150610
2
Mupirocin Approved, Investigational, Vet_approved Phase 4,Not Applicable 12650-69-0 446596
3
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
4
Losartan Approved Phase 4 114798-26-4 3961
5
Enalaprilat Approved Phase 4 76420-72-9 6917719
6
Benzocaine Approved, Investigational Phase 4,Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
7
tannic acid Approved Phase 4,Phase 3,Not Applicable 1401-55-4
8
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
9
Spironolactone Approved Phase 4,Not Applicable 1952-01-7, 52-01-7 5833
10
Hydralazine Approved Phase 4 86-54-4 3637
11
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613
12
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
13
Cefotaxime Approved Phase 4,Phase 3,Not Applicable 63527-52-6 5742673 456256
14
Cefoxitin Approved Phase 4,Phase 3,Not Applicable 35607-66-0 441199
15
Azithromycin Approved Phase 4 83905-01-5 447043 55185
16
Vancomycin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1404-90-6 14969 441141
17
Imipenem Approved Phase 4,Phase 3,Not Applicable 64221-86-9, 74431-23-5 104838
18
Carvedilol Approved, Investigational Phase 4,Not Applicable 72956-09-3 2585
19
Propranolol Approved, Investigational Phase 4,Phase 3,Not Applicable 525-66-6 4946
20
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5479529 5361202
21
Metronidazole Approved Phase 4,Phase 3,Phase 2 443-48-1 4173
22
Cefazolin Approved Phase 4,Phase 3,Not Applicable 25953-19-9 33255 656510
23
Ceftazidime Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 72558-82-8, 78439-06-2 5481173
24
Norfloxacin Approved Phase 4,Phase 2,Phase 3,Not Applicable 70458-96-7 4539
25
Cefepime Approved, Investigational Phase 4,Not Applicable 88040-23-7 5479537
26
Icodextrin Approved, Investigational Phase 4,Phase 2,Phase 1 337376-15-5
27
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
28
Micafungin Approved, Investigational Phase 4 235114-32-6 477468 3081921
29
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
30
Ceftriaxone Approved Phase 4,Phase 3,Not Applicable 73384-59-5 5479530 5361919
31
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 10909430 439542
32
Polymyxin B Approved, Vet_approved Phase 4,Phase 3,Not Applicable 1404-26-8
33
Tigecycline Approved Phase 4,Phase 3 220620-09-7 5282044
34
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
35
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
36
Sultamicillin Approved, Investigational Phase 4 76497-13-7
37
Sulbactam Approved Phase 4 68373-14-8
38
Cilastatin Approved, Investigational Phase 4,Phase 3 82009-34-5 6435415 5280454
39
Nadroparin Approved, Investigational Phase 4
40
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
41
Dipyridamole Approved Phase 4 58-32-2 3108
42
Warfarin Approved Phase 4,Not Applicable 81-81-2 54678486 6691
43
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
44
Heparin Approved, Investigational Phase 4,Phase 2,Not Applicable 9005-49-6 46507594 772
45
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 2713 9552079
46
Lenograstim Approved, Investigational Phase 4,Phase 2,Phase 3 135968-09-1
47
Sargramostim Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 123774-72-1, 83869-56-1
48
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 616-91-1 12035
49
Lactulose Approved Phase 4,Phase 2,Phase 3,Not Applicable 4618-18-2 11333
50
chenodeoxycholic acid Approved Phase 4,Phase 3 474-25-9 10133

Interventional clinical trials:

(show top 50) (show all 347)
# Name Status NCT ID Phase Drugs
1 Randomized Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis (SBP) Unknown status NCT00761098 Phase 4 Standard Care;Experimental
2 Probiotics Use in the Chronic Peritoneal Dialysis Patients Unknown status NCT01076426 Phase 4 Pro-biotics
3 PROPHYlactic Implantation of BIOlogic Mesh in Peritonitis (PROPHYBIOM) Unknown status NCT02277262 Phase 4
4 Antibiotics Versus Surgery in Acute Appendicitis Unknown status NCT01421901 Phase 4 Ertapenem
5 Topical Gentamicin Cream Versus Alternating Gentamicin and Mupirocin Cream in Peritoneal Dialysis Unknown status NCT00751374 Phase 4 gentamicin;gentamicin cream alternating with mupirocin cream
6 The Effect of Enalapril and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis Patients Unknown status NCT01041963 Phase 4 Enalapril;Enalapril plus Losartan;Placebo
7 Empirical vs 2nd Line Antibiotic Therapy in Health-care Associated Infections in Cirrhosis Unknown status NCT01820026 Phase 4 Imipenem;Vancomycin;azithromycin;Cefotaxime;Amoxicillin
8 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
9 The Effect of Carvedilol VS Endoscopic Therapy in Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding Unknown status NCT02695732 Phase 4 Carvedilol
10 The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding Unknown status NCT02385422 Phase 4 Carvedilol;Propranolol
11 The Effect of Branched-chain Amino Acid on the Improvement of Serum Albumin Level in Cirrhotic Patients With Ascites Unknown status NCT02755701 Phase 4 Branched-chain Amino Acid;Placebo
12 Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis Unknown status NCT02505581 Phase 4 Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
13 Prospective Comparison of Primary Abdominal Closure and Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis Completed NCT01531543 Phase 4
14 Comparing Cefepime Versus Cefazolin Plus Ceftazidime for CAPD-associated Peritonitis Completed NCT02872038 Phase 4 Cefepime;Cefazolin plus Ceftazidime
15 Bacteria Endotoxin in Peritoneal Dialysis Effluent as a Predictor of Relapsing, Recurrent, and Repeat Peritonitis Completed NCT01817309 Phase 4
16 Effect of Icodextrin on the Treatment Outcome of Peritoneal Dialysis Patients During Acute Peritonitis Completed NCT01044446 Phase 4 Icodextrin;glucose-based peritoneal dialysate
17 IV Antibiotics With Lavage for Severe PD Peritonitis Completed NCT02926846 Phase 4 Intravenous vancomycin & gentamicin with adjunctive lavage;Intraperitoneal vancomycin & gentamicin
18 Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis Completed NCT02805049 Phase 4 Echinocandins
19 Norfloxacin Versus Ciprofloxacin for Spontaneous Bacterial Peritonitis (SBP) Prevention Completed NCT01542801 Phase 4 Norfloxacin;ciprofloxacin
20 Norfloxacin In The Primary Prophylaxis Of Spontaneous Bacterial Peritonitis Completed NCT00359853 Phase 4 Oral norfloxacin
21 Randomized Controlled Trial Comparing Residual Kidney Function in Patients Undergoing Three or Four Exchanges CAPD Completed NCT01637792 Phase 4
22 Comparison of Efficacy of Cefotaxime, Ceftriaxone, and Ciprofloxacin for the Treatment of SBP in Patients With LC Completed NCT01265173 Phase 4 Cefotaxime;Ceftriaxone;Ciprofloxacin
23 Open Label Trial to Establish the Equivalence Between ANDY-Disc® and Ultrabag® in Patients on CAPD. Completed NCT00255619 Phase 4
24 Beneficial Effect of Probiotics on Chronic Kidney Disease Completed NCT01391468 Phase 4
25 Omega-3 Fatty Acids and Postoperative Complications After Colorectal Surgery Completed NCT00488904 Phase 4
26 Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
27 Administration of pH-Neutral Peritoneal Dialysis Solutions Containing Lactate or Bicarbonate in Children Completed NCT01632046 Phase 4 lactate and bicarbonate buffered dialysis solutions
28 Use of Ointments in Prevention of Catheter Related Infections in PD Completed NCT00400595 Phase 4 Mupirocin ointment;Polysporin Triple
29 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
30 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
31 Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial Completed NCT01760967 Phase 4 Dexmedetomidine
32 COMPRES - COMpression Anastomosis Ring (CAR™ 27/ColonRing™) Post maRketing Evaluation Study Completed NCT01091155 Phase 4
33 T.E.A. Study Three Days Ertapenem Versus Three Days Ampicillin- Sulbactam Completed NCT00630513 Phase 4 Ertapenem;Ampicillin-Sulbactam
34 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
35 Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Completed NCT01959711 Phase 4
36 A Study To Determine The Efficacy And Safety Of Tigecycline Compared With Imipenem/Cliastatin to Treat Complicated Intra-Abdominal Infection Completed NCT01721408 Phase 4 Tigecycline;Imipenem/cilastatin
37 Gastrostomy Tube Placed After Gastropexy Versus Gastrostomy Tube Placed Using the Traditional Push/Pull Techniques Completed NCT01463540 Phase 4
38 Effect of Glucose Degradation Products (GDP) on Endothelial Dysfunction Completed NCT01315314 Phase 4 Balance, Fresenius Medical Care, Germany
39 Non Operative Treatment for Acute Appendicitis Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
40 The Effect of Neutral Peritoneal Dialysis (PD) Solution With Minimal Glucose-Degradation-Product (GDP) on Fluid Status and Body Composition Completed NCT00966615 Phase 4
41 Warfarin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy and Azygoportal Disconnection Completed NCT02247414 Phase 4 Warfarin;Dipyridamole;Aspirin;Low Molecular Weight Heparin
42 Efficacy and Safety of Rheosorbilact® Solution for Infusion, in a Complex Therapy of Peritonitis Recruiting NCT03771170 Phase 4 Rheosorbilact®;Ringer lactate
43 The Efficacy of Prolonged Antibiotic Therapy for the Prevention of Relapsing Peritonitis in Peritoneal Dialysis Patients With High Dialysis Effluent Bacterial DNA Fragment Levels Recruiting NCT02593201 Phase 4 Extended antibiotics (cefazolin or ceftazidime);Usual antibiotics (cefazolin or ceftazidime)
44 Chlorhexidine Gluconate Versus Mupirocin Ointment in the Prevention of Peritoneal Dialysis-Related Infection Recruiting NCT02547103 Phase 4
45 FEcal Transplant, a Hope to Eradicate Colonization of Patient Harboring eXtreme Drug Resistant Bacteria? Recruiting NCT03029078 Phase 4 fecal microbiota transplant
46 GCSF in Alcoholic Hepatitis Recruiting NCT03703674 Phase 4 GCSF
47 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
48 G-CSF Plus NAC In Severe Alcoholic Hepatitis Recruiting NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
49 Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy Recruiting NCT02238444 Phase 4 Warfarin;Dipyridamole;Aspirin;Low Molecular Weight Heparin
50 Peritoneal Dialysis Pilot Study: Evaluating Polyethylene Glycol (PEG) for Constipation Recruiting NCT03148002 Phase 4 Current Bowel Protocol (senna/lactulose);PEG Bowel Protocol (PEG/lactulose)

Search NIH Clinical Center for Peritonitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: peritonitis

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Genetic Tests for Peritonitis

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Sources

Anatomical Context for Peritonitis

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MalaCards organs/tissues related to Peritonitis:

42
Colon, Kidney, Neutrophil, Testes, Small Intestine, Heart, Pancreas
Sources

Publications for Peritonitis

About this section

Articles related to Peritonitis:

(show top 50) (show all 4163)
# Title Authors Year
1
Streptococcus pneumoniae primary peritonitis mimicking acute appendicitis in an immunocompetent patient: a case report and review of the literature. ( 31029142 )
2019
2
Tuberculous peritonitis in a cerebral palsy patient: A challenge in diagnosis and management. ( 31022625 )
2019
3
Peritonitis and pneumoperitoneum after successful emergency pericardiocentesis in the case of a Chilaiditi syndrome. ( 30800153 )
2019
4
Letter to the Editor: Perforated Diverticulitis with Generalized Peritonitis: Low Stoma Rate Using a "Damage Control Strategy". ( 30680498 )
2019
5
Authors' Reply: Perforated Diverticulitis with Generalized Peritonitis: Low Stoma Rate Using a "Damage Control Strategy". ( 30820735 )
2019
6
Damage control surgery for perforated diverticulitis with diffuse peritonitis: saves lives and reduces ostomy. ( 31015859 )
2019
7
Primary Anastomosis for Perforated Diverticulitis with Peritonitis: Post-hoc Pooled Analysis of Prospective Randomized Trials. ( 31037716 )
2019
8
Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis. ( 30706253 )
2019
9
Hemophagocytic lymphohistiocytosis followed by an episode of peritoneal dialysis associated peritonitis: a case report. ( 30696397 )
2019
10
Salmonella enterica serovar enteritidis peritonitis with spontaneous intestinal perforation in an immunocompetent patient. ( 30898965 )
2019
11
Accuracy of calprotectin using the Quantum Blue Reader for the diagnosis of spontaneous bacterial peritonitis in liver cirrhosis. ( 30084186 )
2019
12
A case of uterine lymphangioleiomyomatosis in a young woman that was identified via peritonitis. ( 30338891 )
2019
13
Tuberculosis Peritonitis Mimicking Ovarian Cancer Metastasis. ( 30828043 )
2019
14
Paracoccus yeei as a cause of peritoneal dialysis peritonitis in the United Kingdom. ( 30701158 )
2019
15
Feline infectious peritonitis in a cat presented because of papular skin lesions. ( 30705455 )
2019
16
Prophylaxis of spontaneous bacterial peritonitis: Is there still room for quinolones? ( 30718094 )
2019
17
A differentiated approach to repeat small-bowel anastomoses in patients with postoperative peritonitis: a prospective cohort study. ( 30719528 )
2019
18
Reply to: "Prophylaxis of spontaneous bacterial peritonitis: is there still room for quinolones?" ( 30723006 )
2019
19
Sensitivity of a bedside reagent strip for the detection of spontaneous bacterial peritonitis in ED patients with ascites. ( 30737002 )
2019
20
Bacterial peritonitis in a patient with malignant ascites caused by pancreatic carcinoma: Case report and review of literature. ( 30738726 )
2019
21
Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. ( 30755068 )
2019
22
Evidence of Significant Ceftriaxone and Quinolone Resistance in Cirrhotics with Spontaneous Bacterial Peritonitis. ( 30761472 )
2019
23
Biceps tendon rupture associated with ciprofloxacin use for spontaneous bacterial peritonitis prophylaxis. ( 30765450 )
2019
24
Application of the Kiewiet-Van Ruler model to predict the need for relaparotomy in patients with secondary peritonitis. ( 30768057 )
2019
25
Current management of diffuse peritonitis - is postoperative continuous lavage still a relevant method of choice? ( 30781962 )
2019
26
Tanshinone IIA attenuates sepsis-induced immunosuppression and improves survival rate in a mice peritonitis model. ( 30784917 )
2019
27
Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis. ( 30786830 )
2019
28
A rare agent of continuous ambulatory peritoneal dialysis peritonitis: Rhizobium Radiobacter. ( 30804290 )
2019
29
Successful treatment of peritoneal dialysis-related peritonitis caused by Dermacoccus nishinomiyaensis. ( 30830670 )
2019
30
Personalized medicine with IgGAM compared with standard of care for treatment of peritonitis after infectious source control (the PEPPER trial): study protocol for a randomized controlled trial. ( 30832742 )
2019
31
ISPD guideline-driven retraining, exit site care and decreased peritonitis: a single-center experience in Israel. ( 30834483 )
2019
32
Correction to: Pluronic‑based nano‑self‑assemblies of bacitracin A with a new mechanism of action for an efficient in vivo therapeutic effect against bacterial peritonitis. ( 30841879 )
2019
33
ARE ISPD GUIDELINES ON PERITONITIS DIAGNOSIS TOO NARROW? A 15-YEAR RETROSPECTIVE SINGLE-CENTER COHORT STUDY ON PD-ASSOCIATED PERITONITIS ACCOUNTING FOR UNTRAINED PATIENTS. ( 30846609 )
2019
34
SIMULTANEOUS REMOVAL AND REINSERTION OF THE PD CATHETER IN RELAPSING PERITONITIS. ( 30852521 )
2019
35
THE ASSOCIATION OF COGNITIVE IMPAIRMENT WITH PERITONEAL DIALYSIS-RELATED PERITONITIS. ( 30852523 )
2019
36
Exserohilum Peritonitis in Peritoneal Dialysis in Northern China: A Case Report. ( 30858284 )
2019
37
Peritonitis by Exophiala dermatitidis in a pediatric patient. ( 30859060 )
2019
38
Long term control of luteinized thecoma with sclerosing peritonitis with leuprorelin and tamoxifen treatment. ( 30859116 )
2019
39
Cephalosporin resistance in community acquired spontaneous bacterial peritonitis. ( 30881387 )
2019
40
Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Improve Mouse Status in Septic Peritonitis. ( 30903503 )
2019
41
Micrococcus aloeverae - A Rare Cause of Peritoneal Dialysis-Related Peritonitis Confirmed by 16S rRNA Gene Sequencing. ( 30918158 )
2019
42
Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis: Benefit or Risk? ( 30920419 )
2019
43
Comparative efficacy of long-term antibiotic treatments in the primary prophylaxis of spontaneous bacterial peritonitis. ( 30920712 )
2019
44
A Rare Cause of Urinary Peritonitis: Intra-abdominal Adhesion Rupture. ( 30922972 )
2019
45
Amyloid A in Serum and Ascitic Fluid as a Novel Diagnostic Marker of Spontaneous Bacterial Peritonitis. ( 30931865 )
2019
46
Evaluating the best empirical antibiotic therapy in patients with acute-on-chronic liver failure and spontaneous bacterial peritonitis. ( 30944073 )
2019
47
Intraabdominal continuous negative pressure therapy for secondary peritonitis: an observational trial in a maximum care center. ( 30947631 )
2019
48
Concomitant fungal peritonitis and high ascitic amylase as a rare manifestation of gastric perforation. ( 30949359 )
2019
49
Open abdominal management for perforative peritonitis with septic shock: a retrospective analysis on usefulness of a standardized treatment protocol. ( 30949740 )
2019
50
Risk factors for early onset peritonitis: the SCOPE collaborative. ( 30969363 )
2019
Sources

Variations for Peritonitis

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ClinVar genetic disease variations for Peritonitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TMEM67 NM_153704.5(TMEM67): c.1843T> C (p.Cys615Arg) single nucleotide variant Pathogenic/Likely pathogenic rs201893408 GRCh37 Chromosome 8, 94808198: 94808198
2 TMEM67 NM_153704.5(TMEM67): c.1843T> C (p.Cys615Arg) single nucleotide variant Pathogenic/Likely pathogenic rs201893408 GRCh38 Chromosome 8, 93795970: 93795970
3 TMEM67 NM_153704.5(TMEM67): c.1321C> T (p.Arg441Cys) single nucleotide variant Pathogenic/Likely pathogenic rs752362727 GRCh38 Chromosome 8, 93786255: 93786255
4 TMEM67 NM_153704.5(TMEM67): c.1321C> T (p.Arg441Cys) single nucleotide variant Pathogenic/Likely pathogenic rs752362727 GRCh37 Chromosome 8, 94798483: 94798483
Sources

Expression for Peritonitis

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Search GEO for disease gene expression data for Peritonitis.
Sources

Pathways for Peritonitis

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Pathways related to Peritonitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.09 B2M CCL2 CR1 CRP CXCL8 ICAM1
2
TGF-Beta Pathway 65
Show member pathways
 13.6 CCL2 CXCL8 F2 ICAM1 IL10 IL1B
3
Akt Signaling 65
Show member pathways
 13.47 CCL2 CXCL8 IL10 IL1B IL6 ITGAM
4
Cytokine Signaling in Immune system 67
Show member pathways
 13.45 B2M CCL2 CXCL8 ICAM1 IL10 IL1B
5
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 13.16 CCL2 CXCL8 IL10 IL1B IL6 LBP
6
Human cytomegalovirus infection 38
Show member pathways
 13.06 B2M CCL2 CXCL8 ICAM1 IL1B IL6
7
Allograft rejection 38 1
Show member pathways
 12.98 B2M CXCL8 ICAM1 IL10 IL1B IL6
8
Immune response IL-23 signaling pathway 23
Show member pathways
 12.69 CCL2 F2 IL10 IL1B IL6 TNF
9
NF-kappaB Signaling 4
12.67 B2M CCL2 IL10 IL1B TLR2 TNF
10
Th17 cell differentiation 38
Show member pathways
 12.66 IL10 IL1B IL6 TLR2 TNF
11
T cell receptor signaling pathway 38
Show member pathways
 12.57 IL10 IL1B IL6 TNF
12
IL-17 Family Signaling Pathways 66
Show member pathways
 12.46 CCL2 CXCL8 IL1B IL6 TLR2 TNF
13
Toll Comparative Pathway 65
Show member pathways
 12.4 CXCL8 IL1B IL6 LBP TNF
14
Toxoplasmosis 38
Show member pathways
 12.38 CR1 IL10 IL1B ITGAM TLR2 TNF
15
Selenium Micronutrient Network 1
Show member pathways
 12.37 ALB CCL2 CRP F2 ICAM1 IL1B
16
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.33 CXCL8 IL10 IL1B IL6 TNF
17
IL-1 Family Signaling Pathways 66
Show member pathways
 12.33 CXCL8 IL1B IL6 TLR2 TNF
18
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.33 CCL2 CXCL8 F2 ICAM1 IL1B ITGAM
19
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.31 CXCL8 IL6 TLR2 TNF
20
Bacterial infections in CF airways 23
Show member pathways
 12.3 CXCL8 IL1B IL6 LBP TLR2 TNF
21
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.29 CXCL8 IL10 IL1B IL6 TNF
22
C-type lectin receptor signaling pathway 38
Show member pathways
 12.27 IL10 IL1B IL6 TNF
23
Tuberculosis 38
12.22 CR1 IL10 IL1B IL6 ITGAM LBP
24
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.18 CCL2 CXCL8 ICAM1 IL10 IL1B IL6
25
Th1 Differentiation Pathway 66
Show member pathways
 12.17 IL10 IL1B IL6 TLR2 TNF
26
Fluid shear stress and atherosclerosis 38
12.16 CCL2 ICAM1 IL1B TNF
27
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.13 F2 IL1B IL6 ITGAM TLR2 TNF
28
TNF signaling pathway 38
12.1 CCL2 ICAM1 IL1B IL6 TNF
29
Spinal Cord Injury 1
12.08 AQP1 CCL2 CXCL8 ICAM1 IL1B IL6
30
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.07 IL10 IL6 ITGAM TNF
31
NF-kappa B signaling pathway 38
12.04 CXCL8 ICAM1 IL1B LBP TNF
32
Hematopoietic cell lineage 38
12.03 CR1 IL1B IL6 ITGAM TNF
33
AGE-RAGE signaling pathway in diabetic complications 38
12 CCL2 CXCL8 ICAM1 IL1B IL6 TNF
34
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.97 CXCL8 ICAM1 IL6 LBP
35
Salmonella infection (KEGG) 38
11.93 CXCL8 IL1B IL6 LBP
36
Amoebiasis 38
11.93 CXCL8 IL10 IL1B IL6 ITGAM TLR2
37
Innate Lymphoid Cell Differentiation Pathways 66
11.9 IL10 IL1B ITGAM TNF
38
Dendritic Cells Developmental Lineage Pathway 66
11.88 IL10 IL1B IL6 ITGAM TNF
39
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.85 CCL2 IL10 IL1B IL6 TNF
40
Pertussis 38
11.85 CXCL8 IL10 IL1B IL6 ITGAM TNF
41
Phagocytosis of Microbes 65
11.84 CR1 ITGAM TLR2
42
Glucocorticoid receptor regulatory network 1
11.82 CXCL8 ICAM1 IL6
43
Rheumatoid arthritis 38
11.82 CCL2 CXCL8 ICAM1 IL1B IL6 TLR2
44
Lung fibrosis 1
11.78 CCL2 CXCL8 IL1B IL6 TNF
45
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.77 CXCL8 ICAM1 IL1B IL6 TNF
46
Staphylococcus aureus infection 38
11.74 ICAM1 IL10 ITGAM
47
Interleukin-4 and 13 signaling 67
11.67 CCL2 CXCL8 ICAM1 IL10 IL1B IL6
48
amb2 Integrin signaling 1
11.65 ICAM1 IL6 ITGAM TNF
49
MSP-RON Signaling 65
11.62 CCL2 IL1B ITGAM TLR2 TNF
50
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.55 IL1B IL6 TNF
Sources

GO Terms for Peritonitis

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Cellular components related to Peritonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 ALB B2M CCL2 CRP CXCL8 F2
2 external side of plasma membrane GO:0009897 9.73 ADA B2M F2 ICAM1 ITGAM TNF
3 membrane raft GO:0045121 9.67 ICAM1 ITGAM TLR2 TNF
4 cell surface GO:0009986 9.56 ADA B2M CR1 ICAM1 ITGAM LBP
5 extracellular space GO:0005615 9.5 ADA ALB B2M CCL2 CRP CXCL8
6 extracellular exosome GO:0070062 10.02 ALB AQP1 B2M CR1 F2 ICAM1

Biological processes related to Peritonitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.99 ICAM1 IL1B ITGAM TNF
2 response to lipopolysaccharide GO:0032496 9.97 ICAM1 IL10 IL1B LBP TLR2
3 response to drug GO:0042493 9.97 ADA AQP1 B2M ICAM1 IL10
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 ICAM1 IL1B IL6 TLR2 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 IL10 IL1B IL6 TNF
6 neutrophil chemotaxis GO:0030593 9.89 CCL2 CXCL8 IL1B
7 cellular response to interleukin-1 GO:0071347 9.89 CCL2 CXCL8 ICAM1
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 CCL2 ICAM1 TNF
9 response to insulin GO:0032868 9.88 ICAM1 IL10 TLR2
10 cellular response to organic cyclic compound GO:0071407 9.88 CCL2 IL1B TNF
11 defense response to Gram-positive bacterium GO:0050830 9.88 CRP IL6 LBP TLR2 TNF
12 humoral immune response GO:0006959 9.86 CCL2 IL6 TNF
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 IL1B TLR2 TNF
14 response to hypoxia GO:0001666 9.85 ADA ICAM1 TLR2
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 ICAM1 IL1B TNF
16 protein kinase B signaling GO:0043491 9.82 CCL2 IL1B TNF
17 acute-phase response GO:0006953 9.81 CRP F2 IL6 LBP
18 inflammatory response GO:0006954 9.81 CCL2 CRP CXCL8 IL10 IL1B IL6
19 negative regulation of neurogenesis GO:0050768 9.8 IL1B IL6 TNF
20 microglial cell activation GO:0001774 9.79 ITGAM TLR2 TNF
21 embryonic digestive tract development GO:0048566 9.79 ADA CXCL8 TNF
22 positive regulation of glial cell proliferation GO:0060252 9.78 IL1B IL6 TNF
23 response to glucocorticoid GO:0051384 9.77 IL10 IL6 TNF
24 negative regulation of growth of symbiont in host GO:0044130 9.77 IL10 LBP TNF
25 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL6 LBP TLR2 TNF
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 IL10 IL1B TNF
27 positive regulation of interleukin-8 production GO:0032757 9.76 IL1B LBP TLR2 TNF
28 negative regulation of interleukin-12 production GO:0032695 9.72 IL10 MEFV
29 PERK-mediated unfolded protein response GO:0036499 9.72 CCL2 CXCL8
30 cellular response to lipoteichoic acid GO:0071223 9.71 LBP TLR2
31 opsonization GO:0008228 9.71 CRP LBP
32 negative regulation of lipid storage GO:0010888 9.71 CRP IL6 TNF
33 positive regulation of chemokine production GO:0032722 9.71 IL6 LBP TLR2 TNF
34 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
35 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
36 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
37 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
38 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.68 ICAM1 TNF
39 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
40 positive regulation of neuroinflammatory response GO:0150078 9.67 IL1B IL6 TNF
41 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
42 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 CCL2 IL1B LBP TLR2 TNF
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.64 IL1B TNF
44 receptor biosynthetic process GO:0032800 9.64 IL10 TNF
45 positive regulation of neutrophil chemotaxis GO:0090023 9.62 CXCL8 LBP
46 response to molecule of bacterial origin GO:0002237 9.62 B2M CXCL8 IL10 TLR2
47 cytokine-mediated signaling pathway GO:0019221 9.61 CCL2 CXCL8 ICAM1 IL10 IL1B IL6
48 chronic inflammatory response to antigenic stimulus GO:0002439 9.35 TNF
49 cellular response to lipopolysaccharide GO:0071222 9.23 CCL2 CXCL8 ICAM1 IL10 IL1B IL6
50 immune system process GO:0002376 10.14 B2M CR1 ITGAM LBP MEFV TLR2

Molecular functions related to Peritonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93