MCID: PRT036
MIFTS: 64

Peritonitis

Categories: Gastrointestinal diseases, Infectious diseases, Rare diseases
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Aliases & Classifications for Peritonitis

MalaCards integrated aliases for Peritonitis:

Name: Peritonitis 11 75 53 5 43 14 16 71 31 33
Retractile Mesenteritis 11 19 71
Sclerosing Mesenteritis 11 19 71
Idiopathic Sclerosing Mesenteritis 19 75
Peritoneal Retractile Mesenteritis 19 71
Acute Generalized Peritonitis 11 71
Primary Bacterial Peritonitis 11 71
Mesenteric Panniculitis 19 71
Peritonitis of Undetermined Cause 33
Peritonitis of Unspecified Cause 33
Acute Peritoneal Inflammation 33
Acute Idiopathic Peritonitis 33
Acute Lesser Sac Peritonitis 33
Generalised Peritonitis Nos 33
Liposclerotic Mesenteritis 19
Acute Primary Peritonitis 33
Mesenteric Lipodystrophy 19
Mesenteric Lipogranuloma 19
Pneumococcal Peritonitis 33
Mesenteric Fibromatosis 19
Fibromatosis, Abdominal 71
Peritoneum Inflammation 33
Pelvic Peritonitis, Nos 33
Peritoneal Inflammation 33
Abdominal Peritonitis 33
Diffuse Peritonitis 33
Pelviperitonitis 33

Classifications:



External Ids:

Disease Ontology 11 DOID:8283
ICD9CM 34 567.8
MeSH 43 D010538
SNOMED-CT 68 197183001
ICD10 31 K65 K65.9
UMLS 71 C0025470 C0029823 C0031154 more

Summaries for Peritonitis

GARD: 19 Sclerosing mesenteritis is one of many terms that describes a spectrum of inflammatory disorders that affect the mesentery. The mesentery is the membrane that anchors the small intestine to the back of the abdominal wall. The condition mostly affects men between their 40s and 60s, but women and children can also be affected. It may result in a variety of symptoms including abdominal pain, nausea and vomiting, constipation or diarrhea, weight loss, and fever. Some people have an abdominal mass. The cause of the condition is poorly understood. Suggested possible causes have included previous abdominal surgery or trauma, autoimmunity, paraneoplastic syndromes, ischemic injury, and infection.

MalaCards based summary: Peritonitis, also known as retractile mesenteritis, is related to tuberculous peritonitis and appendicitis. An important gene associated with Peritonitis is TMEM67 (Transmembrane Protein 67), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ertapenem and Dalbavancin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related phenotypes are homeostasis/metabolism and nervous system

Disease Ontology: 11 A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. Peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. The symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output.

Wikipedia 75 Peritonitis: Peritonitis is inflammation of the localized or generalized peritoneum, the lining of the inner wall of... more...

Idiopathic sclerosing mesenteritis: Idiopathic sclerosing mesenteritis (ISM) is a rare disease of the small intestine, characterized by... more...

Related Diseases for Peritonitis

Diseases related to Peritonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1646)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 33.0 MUC16 CRP ALB ADA
2 appendicitis 32.7 TNF LBP IL6 IL1B IL10 CXCL8
3 familial mediterranean fever 32.5 TNF TLR2 IL6 IL1B IL10 CXCL8
4 cyclic neutropenia 32.1 TNF IL1B CXCL8
5 salpingitis 32.0 TNF TLR2 IL6 IL1B IL10 CXCL8
6 amebiasis 31.9 TNF TLR2 IL6 IL1B IL10 CXCL8
7 liver cirrhosis 31.8 TNF TLR2 LBP IL6 F2 ALB
8 intestinal obstruction 31.7 TNF IL6 F2 CRP ALB
9 diverticulitis 31.7 TNF IL6 CRP ALB
10 cholecystitis 31.6 F2 CRP ALB
11 ileus 31.6 TNF IL6 IL1B IL10 CRP CCL2
12 toxic shock syndrome 31.5 TNF TLR2 LBP IL6 IL1B IL10
13 intestinal perforation 31.4 TNF IL6 IL10 F2 CRP ALB
14 liver disease 31.4 TNF IL6 F2 CCL2 ALB
15 hepatic encephalopathy 31.3 TNF IL6 F2 ALB
16 alcoholic liver cirrhosis 31.3 TNF IL6 IL1B F2 CXCL8 ALB
17 typhoid fever 31.3 TNF IL6 IL1B F2 CRP ALB
18 duodenal ulcer 31.3 TNF IL6 IL1B IL10 CXCL8
19 volvulus of midgut 31.3 F2 CRP ALB
20 chronic kidney disease 31.2 TNF IL6 IL1B CRP B2M ALB
21 paralytic ileus 31.2 IL6 F2 CRP ALB
22 acute kidney failure 31.2 IL6 F2 B2M ALB
23 aspergillosis 31.1 TNF TLR2 IL6 IL1B IL10 CXCL8
24 nephrotic syndrome 31.1 TNF IL6 IL1B F2 CRP CCL2
25 gastroenteritis 31.1 TNF IL6 IL1B IL10 CXCL8 CRP
26 brucellosis 31.1 TNF IL6 IL10 CXCL8 CRP ADA
27 nutritional deficiency disease 31.1 IL6 F2 CRP ALB
28 hepatorenal syndrome 31.1 F2 AQP1 ALB
29 splenic abscess 31.1 F2 CRP ALB
30 intussusception 31.1 IL6 CRP ALB
31 enterocolitis 31.0 TNF IL6 IL10 CXCL8 CRP
32 peptic ulcer perforation 31.0 CRP ALB
33 diarrhea 31.0 TNF IL6 IL1B IL10 CXCL8 ALB
34 fasciitis 31.0 TNF IL6 CXCL8
35 abdominal tuberculosis 31.0 TNF F2 CRP ALB ADA
36 pleural empyema 31.0 IL6 F2 CRP ALB ADA
37 peptic ulcer disease 31.0 TNF IL6 IL1B IL10 F2 CXCL8
38 haemophilus influenzae 31.0 TNF TLR2 IL1B CXCL8
39 pelvic inflammatory disease 31.0 TLR2 CRP CCL2
40 alcohol use disorder 30.9 TNF IL6 IL1B F2 CRP ALB
41 intestinal tuberculosis 30.9 TNF CRP ALB ADA
42 acute pancreatitis 30.9 TNF IL6 IL1B IL10 CXCL8 CRP
43 pericarditis 30.9 TNF IL6 IL1B CXCL8 CRP ADA
44 lymphadenitis 30.9 TNF IL6 IL1B IL10 CXCL8 CRP
45 endometritis 30.9 TNF TLR2 IL6 IL1B CXCL8
46 candidiasis 30.9 TNF TLR2 IL6 IL1B IL10 CXCL8
47 adult respiratory distress syndrome 30.9 TNF LBP ITGAM IL6 IL1B IL10
48 compartment syndrome 30.9 TNF IL6 F2 CRP ALB
49 viral infectious disease 30.9 TNF TLR2 IL6 IL1B IL10 CXCL8
50 disseminated intravascular coagulation 30.9 TNF IL6 IL10 F2 CRP CCL2

Comorbidity relations with Peritonitis via Phenotypic Disease Network (PDN): (show all 13)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Chronic Kidney Disease Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intestinal Obstruction Intestinal Perforation
Paralytic Ileus Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Peritonitis:



Diseases related to Peritonitis

Symptoms & Phenotypes for Peritonitis

MGI Mouse Phenotypes related to Peritonitis:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 ADA ALB AQP1 B2M CCL2 CRP
2 nervous system MP:0003631 10.26 AQP1 B2M CCL2 F2 IL10 IL1B
3 liver/biliary system MP:0005370 10.13 ADA ALB B2M CCL2 IL10 IL6
4 cellular MP:0005384 10.13 ADA ALB B2M CCL2 F2 FCGR1A
5 cardiovascular system MP:0005385 10.13 ADA ALB AQP1 B2M CCL2 CRP
6 neoplasm MP:0002006 10.1 ALB B2M CCL2 IL10 IL1B IL6
7 immune system MP:0005387 10.09 ADA ALB AQP1 B2M CCL2 CRP
8 digestive/alimentary MP:0005381 10.07 ADA ALB B2M CCL2 F2 IL10
9 muscle MP:0005369 10.06 ADA ALB CCL2 F2 IL10 IL6
10 skeleton MP:0005390 9.77 ADA AQP1 CCL2 CXCL2 F2 FCGR1A
11 hematopoietic system MP:0005397 9.5 ADA AQP1 B2M CCL2 CXCL2 F2

Drugs & Therapeutics for Peritonitis

Drugs for Peritonitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 142)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
2
Dalbavancin Approved, Investigational Phase 4 171500-79-1 16134627
3
Norfloxacin Approved Phase 4 70458-96-7 4539
4
Ceftriaxone Approved Phase 4 73384-59-5 5479530
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1, 93107-08-5 2764
6
Vancomycin Approved Phase 4 1404-90-6 14969
7
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
8
Tigecycline Approved Phase 4 220620-09-7 5282044
9
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 2826718
10
Micafungin Approved, Investigational Phase 4 235114-32-6 477468
11
Icodextrin Approved, Investigational Phase 4 337376-15-5
12
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
13
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
14
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
15
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
16
Propranolol Approved, Investigational Phase 4 318-98-9, 525-66-6 62882 4946
17
Metronidazole Approved Phase 4 443-48-1, 69198-10-3 4173
18
Teicoplanin Approved, Investigational Phase 4 61036-62-2 16170201
19
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
20
Cefoxitin Approved Phase 4 35607-66-0 441199
21 Analgesics Phase 4
22 Cytochrome P-450 Enzyme Inhibitors Phase 4
23 Antitubercular Agents Phase 4
24 Antiparasitic Agents Phase 4
25 Antiprotozoal Agents Phase 4
26 Hormones Phase 4
27 Calcium, Dietary Phase 4
28 Echinocandins Phase 4
29 Gentamicins Phase 4
30 Antioxidants Phase 4
31 Protective Agents Phase 4
32 Neurotransmitter Agents Phase 4
33 Adrenergic alpha-Agonists Phase 4
34 Adrenergic Agonists Phase 4
35 Adrenergic Agents Phase 4
36 Anti-Anxiety Agents Phase 4
37 Psychotropic Drugs Phase 4
38 Anesthetics, Intravenous Phase 4
39 Hypnotics and Sedatives Phase 4
40 GABA Modulators Phase 4
41 Analgesics, Non-Narcotic Phase 4
42 Adrenergic beta-Antagonists Phase 4
43 Adrenergic Antagonists Phase 4
44 Adrenergic alpha-Antagonists Phase 4
45 Adrenergic alpha-1 Receptor Antagonists Phase 4
46 Anti-Arrhythmia Agents Phase 4
47 Antihypertensive Agents Phase 4
48 Vasodilator Agents Phase 4
49 calcium channel blockers Phase 4
50 Blood Substitutes Phase 4

Interventional clinical trials:

(show top 50) (show all 181)
# Name Status NCT ID Phase Drugs
1 PROPHYlactic Implantation of BIOlogic Mesh in Peritonitis (PROPHYBIOM) Unknown status NCT02277262 Phase 4
2 A Randomized Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis Unknown status NCT00761098 Phase 4 Standard Care;Experimental
3 The Clinical Use of Probiotics in the Uremia Patients Under Chronic Peritoneal Dialysis Unknown status NCT01076426 Phase 4 Pro-biotics
4 Antibiotics vs.Surgery in Acute Appendicitis;an Intention to Treat Prospective Randomised Study. The ASAA-study Unknown status NCT01421901 Phase 4 Ertapenem
5 Open-label, Randomized, Controlled, With Blind Assessor, Study to Assess Efficacy and Safety of Rheosorbilact®, Solution for Infusion, in Comparison With Ringer's Lactate,Solution for Infusion, in a Complex Therapy of Peritonitis. Completed NCT03771170 Phase 4 Rheosorbilact®;Ringer lactate
6 The Efficacy of Prolonged Antibiotic Therapy for the Prevention of Relapsing Peritonitis in Peritoneal Dialysis Patients With High Dialysis Effluent Bacterial DNA Fragment Levels Completed NCT02593201 Phase 4 Extended antibiotics (cefazolin or ceftazidime);Usual antibiotics (cefazolin or ceftazidime)
7 Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis Completed NCT02805049 Phase 4 Echinocandins
8 Randomized Double-Blid Placebo Controlled Trial Assessing Norfloxacin In The Primary Prophylaxis Of Spontaneous Bacterial Peritonitis In Advanced Cirrhosis Completed NCT00359853 Phase 4 Oral norfloxacin
9 Comparison of Efficacy of Cefotaxime, Ceftriaxone, and Ciprofloxacin for the Treatment of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis Completed NCT01265173 Phase 4 Cefotaxime;Ceftriaxone;Ciprofloxacin
10 Comparison of Daily Norfloxacin Versus Weekly Ciprofloxacin for the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients Completed NCT01542801 Phase 4 Norfloxacin;ciprofloxacin
11 Randomized Trial on Intravenous Antibiotics With Adjunctive Lavage for Severe Peritoneal-dialysis Related Peritonitis Completed NCT02926846 Phase 4 Intravenous vancomycin & gentamicin with adjunctive lavage;Intraperitoneal vancomycin & gentamicin
12 Phase 4 Study of Primary Use of the Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis Completed NCT01531543 Phase 4
13 A Multicenter, Randomized, Controlled Trial Comparing Cefepime Monotherapy Versus Combination of Cefazolin Plus Ceftazidime for Empirical Treatment of CAPD-associated Peritonitis Completed NCT02872038 Phase 4 Cefepime;Cefazolin plus Ceftazidime
14 Bacteria Endotoxin in Peritoneal Dialysis Effluent as a Predictor of Relapsing, Recurrent, and Repeat Peritonitis Completed NCT01817309 Phase 4
15 Effects of Dexmedetomidine vs Propofol on Inflammatory Response and Intra-abdominal Pressure in Patients With Intra-abdominal Sepsis; a Randomized Clinical Trial Completed NCT04718714 Phase 4 Midazolam;Propofol;Dexmedetomidine
16 FEcal Transplant, a Hope to Eradicate Colonization of Patient Harboring eXtreme Drug Resistant Bacteria? Completed NCT03029078 Phase 4 fecal microbiota transplant
17 Multicenter, Randomized, Double-blind, Placebo-controlled Study on the Effectiveness of Treatment With Beta-blockers to Prevent Decompensation of Cirrhosis With Portal Hypertension Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
18 Effect of Icodextrin on the Treatment Outcome of Peritoneal Dialysis Patients Completed NCT01044446 Phase 4 Icodextrin;glucose-based peritoneal dialysate
19 Randomized Controlled Trial Comparing Residual Kidney Function in Patients Undergoing Three or Four Exchanges CAPD Completed NCT01637792 Phase 4
20 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
21 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
22 Evaluation of Intravenous and Intraperitoneal Pharmacokinetics of Dalbavancin in Peritoneal Dialysis Patients Completed NCT02940730 Phase 4 Dalbavancin via Intravenous Administration;Dalbavancin via Intraperitoneal Administration
23 Prospective Trial Comparing the Performance Profiles of Two Non-Cross-Linked Porcine Dermal Matrices in Abdominal Wall Reconstruction Recruiting NCT02228889 Phase 4
24 Meropenem vs Cefotaxime as Empirical Treatment of Spontaneous Bacterial Peritonitis :Prospective Randomized Clinical Trial Not yet recruiting NCT05427747 Phase 4 cefotaxime
25 Albumin Administration in the Prevention of Hepatorenal Syndrome and Death in Patients With Cirrhosis, Bacterial Infections Other Than Spontaneous Bacterial Peritonitis and High Risk of Hospital Mortality Terminated NCT02034279 Phase 4 Albumin
26 Clinical, Inflammatory, and Economic Impact of Dextran 70 in Treating Spontaneous Bacterial Peritonitis Terminated NCT00570960 Phase 4 Dextran 70
27 Defining the Optimal Duration of Treatment for "Low-Risk" Peritoneal Dialysis-Related Peritonitis Withdrawn NCT03675854 Phase 4 Cefazolin
28 Role of Probiotics in the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Randomized Placebo Control Trial Unknown status NCT00678613 Phase 2, Phase 3 Probiotics and Placebo;Probiotics and Norfloxacin
29 The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis): a Prospective, Randomized, Placebo-controlled Phase III Study Unknown status NCT03688295 Phase 3 Antibiotics
30 Peritonitis Prevention After Insertion of Peritoneal Dialysis Catheter. Comparison Between Post - Surgical Intraperitoneal Vs. Intravenous Pre- Surgical Administration Unknown status NCT03046511 Phase 3 Cefazolin
31 Is Spontaneous Bacterial Peritonitis Still Responding to 3rd Generation Cephalosporins? Unknown status NCT02443285 Phase 3 Cefotaxime;ceftriaxone
32 Laparoscopic Peritoneal Lavage or Resection for Generalised Peritonitis for Perforated Diverticulitis: a Nationwide Multicenter Randomised Trial Unknown status NCT01317485 Phase 3
33 Randomized Control Trial of Rifaximin and Norfloxacin in Primary and Secondary Prophylaxis of Spontaneous Bacterial Peritonitis(SBP) in Cirrhotic Patients Completed NCT03695705 Phase 3 Rifaximin 550 mg twice a day and Norfloxacin 400 mg once a day
34 Effects of Intravenous Albumin Administration on Renal Function and Survival in Patients With Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis. A Prospective, Stratified, Randomized and Controlled Study. Completed NCT00124228 Phase 3 Human Albumin
35 Evaluation of Safety and Efficacy of Synbiotic on the Incidence and Recurrence of Spontaneous Bacterial Peritonitis in Cirrhotics: A Randomized, Double Blind Placebo Controlled Trial Completed NCT00947336 Phase 3 Norfloxacin + Synbiotic;Norfloxacin + Placebo
36 Hartmann vs Resection With Anastomosis and Diverting Stoma for Peritonitis Caused by Perforated Left-sided Colon Diverticulitis: a Multicenter Prospective Randomized Study. Completed NCT01239927 Phase 2, Phase 3
37 Effects of Hemoperfusion With a Polymyxin B Membrane in Peritonitis With Septic Shock Completed NCT01222663 Phase 3
38 Comparison of Two Durations of Antibiotic Therapy in the Treatment of Severe Postoperative Peritonitis Admitted in Intensive Care Unit: a Randomised Multicentre Study Completed NCT01311765 Phase 3
39 SIS Multicenter Study of Duration of Antibiotics for Intraabdominal Infection Completed NCT00657566 Phase 3
40 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
41 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
42 Comparative Study of Rifaximin Versus Norfloxacin in the Secondary Prophylaxis of Spontaneous Bacterial Peritonitis Recruiting NCT02120196 Phase 3 Rifaximin;Norfloxacin
43 Primary Prophylaxis for Spontaneous Bacterial Peritonitis in Decompensated Chronic Liver Disease With Small Bowel Bacterial Overgrowth: A Randomised Trial Recruiting NCT04775329 Phase 2, Phase 3 Rifaximin
44 Comparative Study Between the Efficacy of Oral Gemifloxacin and Intravenous Cefotaxime in Treatment of Spontaneous Bacterial Peritonitis Recruiting NCT04168099 Phase 3 Cefotaxime;Gemifloxacin
45 Comparative Study of Norfloxacin Versus Norfloxacin With Itopride in Secondary Prophylaxis of Spontaneous Bacterial Peritonitis Recruiting NCT04161768 Phase 3 Norfloxacin;Itopride
46 Primary Antibiotic Prophylaxis Using Co-trimoxazole to Prevent Spontaneous Bacterial Peritonitis in Cirrhosis Recruiting NCT04395365 Phase 3 Co-Trimoxazole 960Mg Dispersible Tablet;Placebo oral tablet
47 The Potential Role of Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis: A Quadruple Blind Clinical Study Recruiting NCT05511766 Phase 2, Phase 3 Allopurinol 300 MG;Atorvastatin 20mg;Placebo
48 Rifaximin Versus Norfloxacin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis Active, not recruiting NCT04159870 Phase 3 Rifaximin;Norfloxacin
49 A Multicenter, Double-blind, Placebo-controlled Randomized Clinical Trial Comparing Two Strategies of Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Severe Cirrhotic Patients With Ascites : Using or Not Using Rifaximin Active, not recruiting NCT03069131 Phase 3 Rifaximin
50 Clinical Study to Evaluate the Possible Efficacy and Safety of Nitazoxanide in Secondary Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients Not yet recruiting NCT04746937 Phase 3 Nitazoxanide;Norfloxacin

Search NIH Clinical Center for Peritonitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albumin Human, USP
ALBUMIN,AGGREGATED
ALBUMIN,EGG
ALBUMIN,HUMAN INJ
ALBUMIN,MICROSPHERE HUMAN SERUM

Cochrane evidence based reviews: peritonitis

Genetic Tests for Peritonitis

Anatomical Context for Peritonitis

Organs/tissues related to Peritonitis:

MalaCards : Small Intestine, Liver, Colon, Neutrophil, Kidney, Lung, Bone Marrow

Publications for Peritonitis

Articles related to Peritonitis:

(show top 50) (show all 31346)
# Title Authors PMID Year
1
Mortality and risk stratification in patients with Clostridium difficile-associated diarrhoea. 53 62
19508548 2010
2
Predictors of patient survival in continuous ambulatory peritoneal dialysis: 10-year experience in 2 major centers in Tehran. 53 62
20081304 2010
3
Peritonitis from peg tube insertion in surgical intensive care unit patients: identification of risk factors and clinical outcomes. 53 62
19430836 2009
4
AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis. 53 62
19401390 2009
5
Peritoneal resorption capacity for the inflammatory mediators in acute experimental Staphylococcus aureus peritonitis. 53 62
19669960 2009
6
Primary peritonitis due to brucellosis mimicking tuberculous peritonitis. 53 62
19530047 2009
7
Albumin administration in patients with severe sepsis due to secondary peritonitis. 53 62
19467947 2009
8
[Peritonitis in the course of peritoneal dialisis caused by Haemophilus influenzae with BLNAR phenotype]. 53 62
19580200 2009
9
Effect of the combination of fibrin glue and growth hormone on intestinal anastomoses in a pig model of traumatic shock associated with peritonitis. 53 62
19132439 2009
10
Fungal peritonitis in peritoneal dialysis: risk factors and prognosis. 53 62
19142806 2009
11
Is decline in serum albumin an ominous sign for subsequent peritonitis in peritoneal dialysis patients? 53 62
19886340 2009
12
Systemic and intraperitoneal proinflammatory cytokine profiles in patients on continuous ambulatory peritoneal dialysis. 53 62
19886317 2009
13
[The prognostic role of interleukin-6 in peritoneal exudate of patients with diffuse peritonitis]. 53 62
20020622 2009
14
Clinical characteristics of lower bowel perforation with chronic renal failure. 53 62
19102359 2008
15
Concentration of adipokines in peritoneal effluent: a new marker of acute peritonitis in peritoneal dialysis patients? 53 62
18708547 2008
16
The relationship of p1 and lewis antigens with peritoneal dialysis-related Escherichia coli peritonitis. 53 62
18552251 2008
17
The outcome for pediatric patients on peritoneal dialysis. 53 62
18587728 2008
18
TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis. 53 62
18354210 2008
19
[Peritonitis related to peritoneal dialysis: evaluation of 179 attacks]. 53 62
18697424 2008
20
Relation of demographic, clinic and biochemical parameters to peritonitis in peritoneal dialysis. 53 62
18336516 2008
21
Fas expression on peritoneal macrophages during continuous ambulatory peritoneal dialysis peritonitis. 53 62
18350449 2008
22
Proteomic analysis of peritoneal dialysate fluid in patients with dialysis-related peritonitis. 53 62
18791950 2008
23
A leptin serum concentration less than 10 ng/ml is a predictive marker of outcome in patients with moderate to severe secondary peritonitis. 53 62
18525209 2008
24
Streptococcus salivarius bacteremia and spontaneous bacterial peritonitis in liver transplantation candidates. 53 62
17969206 2007
25
Reduced residual renal function is a risk of peritonitis in continuous ambulatory peritoneal dialysis patients. 53 62
17517797 2007
26
Influence of peritoneal dialysis training nurses' experience on peritonitis rates. 53 62
17699477 2007
27
Peritonitis, peritoneal inflammation and membrane permeability: a longitudinal study of dialysate and serum MCP-1 in stable patients on peritoneal dialysis. 53 62
17557268 2007
28
Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis. 53 62
17224788 2007
29
Adherence to peritoneal dialysis training schedule. 53 62
17035375 2007
30
Comparison of incidence of peritonitis between peritoneal dialysis solution types. 53 62
17409770 2007
31
Systemic and intraperitoneal proinflammatory cytokines profiles in patients on chronic peritoneal dialysis. 53 62
18928158 2007
32
Impact of nutritional status on peritonitis in CAPD patients. 53 62
17179509 2007
33
Clinical predictors of ongoing infection in secondary peritonitis: systematic review. 53 62
17102920 2006
34
Malnutrition-inflammation score is a useful tool in peritoneal dialysis patients. 53 62
17047239 2006
35
Anti-inflammatory effects of a novel peptide designed to bind with NF-kappaB p50 subunit. 53 62
17049124 2006
36
Compartmentalization of interleukin-6 response in a patient with septic meningococcal peritonitis. 53 62
16988004 2006
37
Survival and technical failure in a large cohort of Thai CAPD patients. 53 62
17044460 2006
38
Risk factors of first peritonitis episode in Thai CAPD patients. 53 62
17044465 2006
39
Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation. 53 62
16788688 2006
40
Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils. 53 62
16690053 2006
41
Peritonitis in childhood: clinical relevance of cytokines in the peritoneal exudate. 53 62
16685614 2006
42
Timely transfer of peritoneal dialysis patients to hemodialysis improves survival rates. 53 62
16429841 2006
43
Systemic and intraperitoneal interleukin-6 system during the first year of peritoneal dialysis. 53 62
16538876 2006
44
Dialysate CA125 levels in children on continuous peritoneal dialysis. 53 62
16133054 2005
45
The impact of topical mupirocin on peritoneal dialysis infection in Singapore General Hospital. 53 62
16046516 2005
46
Risk factors for peritonitis in pediatric peritoneal dialysis: a single-center study. 53 62
16082548 2005
47
[A contemporary situation in the antimicrobial treatment of the secondary peritonitis]. 53 62
16250620 2005
48
The impact of topical mupirocin on peritoneal dialysis infection rates in Singapore General Hospital. 53 62
15855200 2005
49
A risk analysis of continuous ambulatory peritoneal dialysis-related peritonitis. 53 62
16022095 2005
50
IL-6 transsignaling: the in vivo consequences. 53 62
15871661 2005

Variations for Peritonitis

ClinVar genetic disease variations for Peritonitis:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TMEM67 NM_153704.6(TMEM67):c.1321C>T (p.Arg441Cys) SNV Likely Pathogenic
217725 rs752362727 GRCh37: 8:94798483-94798483
GRCh38: 8:93786255-93786255
2 TMEM67 NM_153704.6(TMEM67):c.1843T>C (p.Cys615Arg) SNV Likely Pathogenic
1383 rs201893408 GRCh37: 8:94808198-94808198
GRCh38: 8:93795970-93795970

Expression for Peritonitis

Search GEO for disease gene expression data for Peritonitis.

Pathways for Peritonitis

Pathways related to Peritonitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 B2M CCL2 CRP CXCL2 CXCL8 F2
2
Show member pathways
13.85 TNF ITGB2 ITGAM IL6 IL1B IL10
3
Show member pathways
13.59 CCL2 CXCL8 F2 IL10 IL1B IL6
4
Show member pathways
13.48 CCL2 CXCL2 CXCL8 IL10 IL1B IL6
5
Show member pathways
13.34 TNF IL6 IL1B IL10 CXCL8 CXCL2
6
Show member pathways
13.23 B2M CCL2 CXCL2 CXCL8 FCGR1A IL10
7
Show member pathways
12.91 TNF TLR2 LBP IL6 IL1B CXCL8
8 12.74 ITGB2 IL6 IL1B IL10 CCL2
9
Show member pathways
12.71 TLR2 ITGB2 ITGAM F2 CRP ALB
10
Show member pathways
12.67 TNF TLR2 IL6 IL1B CXCL8
11
Show member pathways
12.67 TNF IL6 IL1B IL10 F2 CCL2
12 12.63 TNF TLR2 ITGB2 IL1B IL10 CCL2
13
Show member pathways
12.59 TNF TLR2 IL6 IL1B CXCL8
14
Show member pathways
12.52 TNF TLR2 LBP IL6 IL1B CXCL8
15
Show member pathways
12.39 TNF LBP IL6 IL1B CXCL8
16
Show member pathways
12.37 TNF TLR2 IL6 CXCL8 CXCL2 CCL2
17 12.26 TNF IL6 IL1B IL10 CXCL8
18 12.16 TNF IL6 IL1B IL10
19
Show member pathways
12.14 TLR2 ITGB2 ITGAM FCGR1A
20 12.07 TNF ITGAM IL6 IL10
21
Show member pathways
12.03 TNF TLR2 IL6 IL1B IL10
22 12 ITGB2 IL6 IL10 CXCL8 CCL2
23 11.96 TNF IL1B IL10 CXCL8
24 11.93 TNF IL6 IL1B CXCL8 CXCL2 CCL2
25 11.89 TNF ITGAM IL1B IL10
26
Show member pathways
11.88 CCL2 CRP CXCL8 IL6 LBP
27 11.86 TNF IL6 IL1B CXCL8 CCL2
28 11.84 TNF ITGAM IL6 IL1B IL10
29 11.82 IL6 IL10 CXCL8 CCL2
30 11.81 CRP IL10 IL6 ITGB2 TNF
31
Show member pathways
11.79 ITGB2 ITGAM FCGR1A
32 11.78 ITGB2 IL6 IL10
33 11.77 IL10 IL1B IL6 TNF
34 11.76 CXCL8 IL10 IL6 TNF
35
Show member pathways
11.73 TNF TLR2 IL6 IL10
36
Show member pathways
11.73 TNF IL6 IL1B CXCL8 CXCL2
37 11.68 TNF IL6 IL1B CXCL8 CXCL2 CCL2
38 11.66 TNF IL6 CXCL8 CCL2
39 11.63 TNF IL10 CXCL8 CXCL2 CCL2
40 11.62 TNF IL10 CCL2
41 11.56 TNF IL6 CCL2
42 11.55 TNF IL6 IL1B
43 11.55 LBP IL6 CRP
44 11.54 CXCL8 ITGAM ITGB2
45 11.49 TNF IL6 IL1B IL10
46 11.46 IL10 FCGR1A F2
47 11.43 IL6 CXCL8 CCL2
48 11.42 TNF TLR2 ITGB2 ITGAM IL1B CCL2
49 11.39 TNF IL6 IL1B
50 11.38 TNF ITGB2 ITGAM IL6

GO Terms for Peritonitis

Cellular components related to Peritonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 10.13 TNF TLR2 LBP ITGB2 ITGAM B2M
2 extracellular region GO:0005576 10.05 ALB B2M CCL2 CRP CXCL2 CXCL8
3 external side of plasma membrane GO:0009897 10 ADA B2M F2 FCGR1A ITGAM ITGB2
4 extracellular space GO:0005615 9.75 TNF MUC16 LBP ITGAM IL6 IL1B
5 integrin alphaM-beta2 complex GO:0034688 9.56 ITGB2 ITGAM

Biological processes related to Peritonitis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 10.41 CXCL8 IL10 IL1B IL6 TLR2 TNF
2 inflammatory response GO:0006954 10.28 CCL2 CRP CXCL2 CXCL8 IL1B IL6
3 positive regulation of DNA-binding transcription factor activity GO:0051091 10.27 TNF IL6 IL1B IL10
4 positive regulation of interleukin-6 production GO:0032755 10.24 IL1B IL6 LBP TLR2 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.21 TNF TLR2 ITGB2 IL6 IL1B
6 defense response to Gram-positive bacterium GO:0050830 10.21 TNF TLR2 LBP IL6 IL1B CRP
7 positive regulation of interleukin-8 production GO:0032757 10.16 IL1B IL6 LBP TLR2 TNF
8 acute-phase response GO:0006953 10.15 LBP IL6 F2 CRP
9 response to lipopolysaccharide GO:0032496 10.14 TNF TLR2 LBP IL1B IL10
10 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.13 TNF IL6 IL10 F2
11 liver regeneration GO:0097421 10.12 TNF IL6 IL10
12 positive regulation of superoxide anion generation GO:0032930 10.1 CRP ITGAM ITGB2
13 microglial cell activation GO:0001774 10.1 TNF TLR2 ITGB2 ITGAM
14 positive regulation of glial cell proliferation GO:0060252 10.09 TNF IL6 IL1B
15 positive regulation of nitric oxide biosynthetic process GO:0045429 10.08 TNF ITGB2 IL1B
16 embryonic digestive tract development GO:0048566 10.08 TNF CXCL8 ADA
17 negative regulation of neurogenesis GO:0050768 10.08 TNF IL6 IL1B B2M
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.07 IL10 IL1B TNF
19 lipopolysaccharide-mediated signaling pathway GO:0031663 10.07 CCL2 IL1B LBP TLR2 TNF
20 positive regulation of T cell activation GO:0050870 10.06 CCL2 B2M ADA
21 positive regulation of chemokine production GO:0032722 10.06 TNF TLR2 LBP IL6 IL1B
22 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 10.05 TNF ITGB2 IL6
23 positive regulation of neuroinflammatory response GO:0150078 10.04 TNF IL6 IL1B
24 negative regulation of lipid storage GO:0010888 10.03 TNF IL6 CRP
25 neutrophil chemotaxis GO:0030593 10.03 LBP ITGB2 IL1B CXCL8 CXCL2 CCL2
26 vascular endothelial growth factor production GO:0010573 9.99 TNF IL6 IL1B
27 negative regulation of cytokine production involved in immune response GO:0002719 9.98 TNF IL10
28 positive regulation of fever generation GO:0031622 9.98 TNF IL1B
29 immune response GO:0006955 9.97 B2M CCL2 CXCL2 CXCL8 FCGR1A IL10
30 sequestering of triglyceride GO:0030730 9.96 IL1B TNF
31 positive regulation of neutrophil degranulation GO:0043315 9.96 ITGAM ITGB2
32 leukocyte migration GO:0050900 9.95 TNF IL1B ADA
33 positive regulation of prostaglandin-E synthase activity GO:2000363 9.94 ITGB2 ITGAM
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.94 TNF IL1B
35 negative regulation of dopamine metabolic process GO:0045963 9.93 ITGB2 ITGAM
36 chronic inflammatory response to antigenic stimulus GO:0002439 9.93 TNF IL10
37 cellular response to lipopolysaccharide GO:0071222 9.83 TNF LBP IL6 IL1B IL10 CXCL8
38 response to external stimulus GO:0009605 9.76 TLR2 CXCL8 CXCL2
39 cellular extravasation GO:0045123 9.65 ITGB2 TNF
40 response to molecule of bacterial origin GO:0002237 9.28 TLR2 IL10 CXCL8 CXCL2 B2M

Molecular functions related to Peritonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.43 TLR2 LBP F2
2 cytokine activity GO:0005125 9.36 TNF IL6 IL1B IL10 CXCL8 CXCL2

Sources for Peritonitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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