Peritonitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRT036 MIFTS: 64	Peritonitis Categories: Gastrointestinal diseases, Infectious diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Peritonitis

MalaCards integrated aliases for Peritonitis:

Name: Peritonitis ¹¹ ⁷⁵ ⁵³ ⁵ ⁴³ ¹⁴ ¹⁶ ⁷¹ ³¹ ³³

Retractile Mesenteritis ¹¹ ¹⁹ ⁷¹

Sclerosing Mesenteritis ¹¹ ¹⁹ ⁷¹

Idiopathic Sclerosing Mesenteritis ¹⁹ ⁷⁵

Peritoneal Retractile Mesenteritis ¹⁹ ⁷¹

Acute Generalized Peritonitis ¹¹ ⁷¹

Primary Bacterial Peritonitis ¹¹ ⁷¹

Mesenteric Panniculitis ¹⁹ ⁷¹

Peritonitis of Undetermined Cause ³³

Peritonitis of Unspecified Cause ³³

Acute Peritoneal Inflammation ³³

Acute Idiopathic Peritonitis ³³

Acute Lesser Sac Peritonitis ³³

Generalised Peritonitis Nos ³³

Liposclerotic Mesenteritis ¹⁹

Acute Primary Peritonitis ³³

Mesenteric Lipodystrophy ¹⁹

Mesenteric Lipogranuloma ¹⁹

Pneumococcal Peritonitis ³³

Mesenteric Fibromatosis ¹⁹

Fibromatosis, Abdominal ⁷¹

Peritoneum Inflammation ³³

Pelvic Peritonitis, Nos ³³

Peritoneal Inflammation ³³

Abdominal Peritonitis ³³

Diffuse Peritonitis ³³

Pelviperitonitis ³³

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the digestive system

Diseases of peritoneum

Peritonitis

Peritonitis, unspecified

ICD11: ³³

Diseases of the digestive system

Diseases of peritoneum

Peritonitis

Peritonitis, unspecified

Primary peritonitis

Other specified primary peritonitis

Secondary peritonitis

Peritonitis due to Streptococcus pneumoniae

External Ids:

Disease Ontology ¹¹ DOID:8283

ICD9CM ³⁴ 567.8

MeSH ⁴³ D010538

SNOMED-CT ⁶⁸ 197183001

ICD10 ³¹ K65 K65.9

EFO ¹⁶ EFO_0008588

ICD11 ³³ 1300748171 377739172 669087597 more

UMLS ⁷¹ C0025470 C0029823 C0031154 more

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Summaries for Peritonitis

GARD: ¹⁹ Sclerosing mesenteritis is one of many terms that describes a spectrum of inflammatory disorders that affect the mesentery. The mesentery is the membrane that anchors the small intestine to the back of the abdominal wall. The condition mostly affects men between their 40s and 60s, but women and children can also be affected. It may result in a variety of symptoms including abdominal pain, nausea and vomiting, constipation or diarrhea, weight loss, and fever. Some people have an abdominal mass. The cause of the condition is poorly understood. Suggested possible causes have included previous abdominal surgery or trauma, autoimmunity, paraneoplastic syndromes, ischemic injury, and infection.

MalaCards based summary: Peritonitis, also known as retractile mesenteritis, is related to tuberculous peritonitis and appendicitis. An important gene associated with Peritonitis is TMEM67 (Transmembrane Protein 67), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ertapenem and Dalbavancin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related phenotypes are homeostasis/metabolism and nervous system

Disease Ontology: ¹¹ A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. Peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. The symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output.

Wikipedia ⁷⁵ Peritonitis: Peritonitis is inflammation of the localized or generalized peritoneum, the lining of the inner wall of... more...

Idiopathic sclerosing mesenteritis: Idiopathic sclerosing mesenteritis (ISM) is a rare disease of the small intestine, characterized by... more...

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Related Diseases for Peritonitis

Diseases related to Peritonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1646)

#	Related Disease	Score	Top Affiliating Genes
1	tuberculous peritonitis	33.0	MUC16 CRP ALB ADA
2	appendicitis	32.7	TNF LBP IL6 IL1B IL10 CXCL8
3	familial mediterranean fever	32.5	TNF TLR2 IL6 IL1B IL10 CXCL8
4	cyclic neutropenia	32.1	TNF IL1B CXCL8
5	salpingitis	32.0	TNF TLR2 IL6 IL1B IL10 CXCL8
6	amebiasis	31.9	TNF TLR2 IL6 IL1B IL10 CXCL8
7	liver cirrhosis	31.8	TNF TLR2 LBP IL6 F2 ALB
8	intestinal obstruction	31.7	TNF IL6 F2 CRP ALB
9	diverticulitis	31.7	TNF IL6 CRP ALB
10	cholecystitis	31.6	F2 CRP ALB
11	ileus	31.6	TNF IL6 IL1B IL10 CRP CCL2
12	toxic shock syndrome	31.5	TNF TLR2 LBP IL6 IL1B IL10
13	intestinal perforation	31.4	TNF IL6 IL10 F2 CRP ALB
14	liver disease	31.4	TNF IL6 F2 CCL2 ALB
15	hepatic encephalopathy	31.3	TNF IL6 F2 ALB
16	alcoholic liver cirrhosis	31.3	TNF IL6 IL1B F2 CXCL8 ALB
17	typhoid fever	31.3	TNF IL6 IL1B F2 CRP ALB
18	duodenal ulcer	31.3	TNF IL6 IL1B IL10 CXCL8
19	volvulus of midgut	31.3	F2 CRP ALB
20	chronic kidney disease	31.2	TNF IL6 IL1B CRP B2M ALB
21	paralytic ileus	31.2	IL6 F2 CRP ALB
22	acute kidney failure	31.2	IL6 F2 B2M ALB
23	aspergillosis	31.1	TNF TLR2 IL6 IL1B IL10 CXCL8
24	nephrotic syndrome	31.1	TNF IL6 IL1B F2 CRP CCL2
25	gastroenteritis	31.1	TNF IL6 IL1B IL10 CXCL8 CRP
26	brucellosis	31.1	TNF IL6 IL10 CXCL8 CRP ADA
27	nutritional deficiency disease	31.1	IL6 F2 CRP ALB
28	hepatorenal syndrome	31.1	F2 AQP1 ALB
29	splenic abscess	31.1	F2 CRP ALB
30	intussusception	31.1	IL6 CRP ALB
31	enterocolitis	31.0	TNF IL6 IL10 CXCL8 CRP
32	peptic ulcer perforation	31.0	CRP ALB
33	diarrhea	31.0	TNF IL6 IL1B IL10 CXCL8 ALB
34	fasciitis	31.0	TNF IL6 CXCL8
35	abdominal tuberculosis	31.0	TNF F2 CRP ALB ADA
36	pleural empyema	31.0	IL6 F2 CRP ALB ADA
37	peptic ulcer disease	31.0	TNF IL6 IL1B IL10 F2 CXCL8
38	haemophilus influenzae	31.0	TNF TLR2 IL1B CXCL8
39	pelvic inflammatory disease	31.0	TLR2 CRP CCL2
40	alcohol use disorder	30.9	TNF IL6 IL1B F2 CRP ALB
41	intestinal tuberculosis	30.9	TNF CRP ALB ADA
42	acute pancreatitis	30.9	TNF IL6 IL1B IL10 CXCL8 CRP
43	pericarditis	30.9	TNF IL6 IL1B CXCL8 CRP ADA
44	lymphadenitis	30.9	TNF IL6 IL1B IL10 CXCL8 CRP
45	endometritis	30.9	TNF TLR2 IL6 IL1B CXCL8
46	candidiasis	30.9	TNF TLR2 IL6 IL1B IL10 CXCL8
47	adult respiratory distress syndrome	30.9	TNF LBP ITGAM IL6 IL1B IL10
48	compartment syndrome	30.9	TNF IL6 F2 CRP ALB
49	viral infectious disease	30.9	TNF TLR2 IL6 IL1B IL10 CXCL8
50	disseminated intravascular coagulation	30.9	TNF IL6 IL10 F2 CRP CCL2

Comorbidity relations with Peritonitis via Phenotypic Disease Network (PDN): (show all 13)

Active Peptic Ulcer Disease	Acute Cystitis
Acute Kidney Failure	Acute Vascular Insufficiency of Intestine
Chronic Kidney Disease	Deficiency Anemia
Familial Atrial Fibrillation	Heart Disease
Intestinal Obstruction	Intestinal Perforation
Paralytic Ileus	Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Peritonitis:

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Symptoms & Phenotypes for Peritonitis

MGI Mouse Phenotypes related to Peritonitis:

⁴⁵ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.31	ADA ALB AQP1 B2M CCL2 CRP
2	nervous system	MP:0003631	10.26	AQP1 B2M CCL2 F2 IL10 IL1B
3	liver/biliary system	MP:0005370	10.13	ADA ALB B2M CCL2 IL10 IL6
4	cellular	MP:0005384	10.13	ADA ALB B2M CCL2 F2 FCGR1A
5	cardiovascular system	MP:0005385	10.13	ADA ALB AQP1 B2M CCL2 CRP
6	neoplasm	MP:0002006	10.1	ALB B2M CCL2 IL10 IL1B IL6
7	immune system	MP:0005387	10.09	ADA ALB AQP1 B2M CCL2 CRP
8	digestive/alimentary	MP:0005381	10.07	ADA ALB B2M CCL2 F2 IL10
9	muscle	MP:0005369	10.06	ADA ALB CCL2 F2 IL10 IL6
10	skeleton	MP:0005390	9.77	ADA AQP1 CCL2 CXCL2 F2 FCGR1A
11	hematopoietic system	MP:0005397	9.5	ADA AQP1 B2M CCL2 CXCL2 F2

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Drugs & Therapeutics for Peritonitis

Drugs for Peritonitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 142)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ertapenem

Approved, Investigational

Phase 4

153832-46-3

150610

Dalbavancin

Approved, Investigational

Phase 4

171500-79-1

16134627

Norfloxacin

Approved

Phase 4

70458-96-7

4539

Ceftriaxone

Approved

Phase 4

73384-59-5

5479530

Ciprofloxacin

Approved, Investigational

Phase 4

85721-33-1, 93107-08-5

2764

Vancomycin

Approved

Phase 4

1404-90-6

14969

Cefepime

Approved, Investigational

Phase 4

88040-23-7

5479537

Tigecycline

Approved

Phase 4

220620-09-7

5282044

Caspofungin

Approved

Phase 4

179463-17-3, 162808-62-0

2826718

Micafungin

Approved, Investigational

Phase 4

235114-32-6

477468

Icodextrin

Approved, Investigational

Phase 4

337376-15-5

Dexmedetomidine

Approved, Experimental, Vet_approved

Phase 4

86347-14-0, 113775-47-6

68602 5311068

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Carvedilol

Approved, Investigational

Phase 4

72956-09-3

2585

Propranolol

Approved, Investigational

Phase 4

318-98-9, 525-66-6

62882 4946

Metronidazole

Approved

Phase 4

443-48-1, 69198-10-3

4173

Teicoplanin

Approved, Investigational

Phase 4

61036-62-2

16170201

Cefotaxime

Approved

Phase 4

63527-52-6

5742673 456256

Cefoxitin

Approved

Phase 4

35607-66-0

441199

Analgesics

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Antitubercular Agents

Phase 4

Antiparasitic Agents

Phase 4

Antiprotozoal Agents

Phase 4

Hormones

Phase 4

Calcium, Dietary

Phase 4

Echinocandins

Phase 4

Gentamicins

Phase 4

Antioxidants

Phase 4

Protective Agents

Phase 4

Neurotransmitter Agents

Phase 4

Adrenergic alpha-Agonists

Phase 4

Adrenergic Agonists

Phase 4

Adrenergic Agents

Phase 4

Anti-Anxiety Agents

Phase 4

Psychotropic Drugs

Phase 4

Anesthetics, Intravenous

Phase 4

Hypnotics and Sedatives

Phase 4

GABA Modulators

Phase 4

Analgesics, Non-Narcotic

Phase 4

Adrenergic beta-Antagonists

Phase 4

Adrenergic Antagonists

Phase 4

Adrenergic alpha-Antagonists

Phase 4

Adrenergic alpha-1 Receptor Antagonists

Phase 4

Anti-Arrhythmia Agents

Phase 4

Antihypertensive Agents

Phase 4

Vasodilator Agents

Phase 4

calcium channel blockers

Phase 4

Blood Substitutes

Phase 4

Interventional clinical trials:

(show top 50) (show all 181)

#	Name	Status	NCT ID	Phase	Drugs
1	PROPHYlactic Implantation of BIOlogic Mesh in Peritonitis (PROPHYBIOM)	Unknown status	NCT02277262	Phase 4
2	A Randomized Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis	Unknown status	NCT00761098	Phase 4	Standard Care;Experimental
3	The Clinical Use of Probiotics in the Uremia Patients Under Chronic Peritoneal Dialysis	Unknown status	NCT01076426	Phase 4	Pro-biotics
4	Antibiotics vs.Surgery in Acute Appendicitis;an Intention to Treat Prospective Randomised Study. The ASAA-study	Unknown status	NCT01421901	Phase 4	Ertapenem
5	Open-label, Randomized, Controlled, With Blind Assessor, Study to Assess Efficacy and Safety of Rheosorbilact®, Solution for Infusion, in Comparison With Ringer's Lactate,Solution for Infusion, in a Complex Therapy of Peritonitis.	Completed	NCT03771170	Phase 4	Rheosorbilact®;Ringer lactate
6	The Efficacy of Prolonged Antibiotic Therapy for the Prevention of Relapsing Peritonitis in Peritoneal Dialysis Patients With High Dialysis Effluent Bacterial DNA Fragment Levels	Completed	NCT02593201	Phase 4	Extended antibiotics (cefazolin or ceftazidime);Usual antibiotics (cefazolin or ceftazidime)
7	Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis	Completed	NCT02805049	Phase 4	Echinocandins
8	Randomized Double-Blid Placebo Controlled Trial Assessing Norfloxacin In The Primary Prophylaxis Of Spontaneous Bacterial Peritonitis In Advanced Cirrhosis	Completed	NCT00359853	Phase 4	Oral norfloxacin
9	Comparison of Efficacy of Cefotaxime, Ceftriaxone, and Ciprofloxacin for the Treatment of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis	Completed	NCT01265173	Phase 4	Cefotaxime;Ceftriaxone;Ciprofloxacin
10	Comparison of Daily Norfloxacin Versus Weekly Ciprofloxacin for the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients	Completed	NCT01542801	Phase 4	Norfloxacin;ciprofloxacin
11	Randomized Trial on Intravenous Antibiotics With Adjunctive Lavage for Severe Peritoneal-dialysis Related Peritonitis	Completed	NCT02926846	Phase 4	Intravenous vancomycin & gentamicin with adjunctive lavage;Intraperitoneal vancomycin & gentamicin
12	Phase 4 Study of Primary Use of the Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis	Completed	NCT01531543	Phase 4
13	A Multicenter, Randomized, Controlled Trial Comparing Cefepime Monotherapy Versus Combination of Cefazolin Plus Ceftazidime for Empirical Treatment of CAPD-associated Peritonitis	Completed	NCT02872038	Phase 4	Cefepime;Cefazolin plus Ceftazidime
14	Bacteria Endotoxin in Peritoneal Dialysis Effluent as a Predictor of Relapsing, Recurrent, and Repeat Peritonitis	Completed	NCT01817309	Phase 4
15	Effects of Dexmedetomidine vs Propofol on Inflammatory Response and Intra-abdominal Pressure in Patients With Intra-abdominal Sepsis; a Randomized Clinical Trial	Completed	NCT04718714	Phase 4	Midazolam;Propofol;Dexmedetomidine
16	FEcal Transplant, a Hope to Eradicate Colonization of Patient Harboring eXtreme Drug Resistant Bacteria?	Completed	NCT03029078	Phase 4	fecal microbiota transplant
17	Multicenter, Randomized, Double-blind, Placebo-controlled Study on the Effectiveness of Treatment With Beta-blockers to Prevent Decompensation of Cirrhosis With Portal Hypertension	Completed	NCT01059396	Phase 4	propranolol;carvedilol;placebo
18	Effect of Icodextrin on the Treatment Outcome of Peritoneal Dialysis Patients	Completed	NCT01044446	Phase 4	Icodextrin;glucose-based peritoneal dialysate
19	Randomized Controlled Trial Comparing Residual Kidney Function in Patients Undergoing Three or Four Exchanges CAPD	Completed	NCT01637792	Phase 4
20	A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection	Completed	NCT00195351	Phase 4	tigecycline;ceftriaxone sodium + metronidazole
21	A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection	Completed	NCT00230971	Phase 4	tigecycline;ceftriaxone plus metronidazole
22	Evaluation of Intravenous and Intraperitoneal Pharmacokinetics of Dalbavancin in Peritoneal Dialysis Patients	Completed	NCT02940730	Phase 4	Dalbavancin via Intravenous Administration;Dalbavancin via Intraperitoneal Administration
23	Prospective Trial Comparing the Performance Profiles of Two Non-Cross-Linked Porcine Dermal Matrices in Abdominal Wall Reconstruction	Recruiting	NCT02228889	Phase 4
24	Meropenem vs Cefotaxime as Empirical Treatment of Spontaneous Bacterial Peritonitis :Prospective Randomized Clinical Trial	Not yet recruiting	NCT05427747	Phase 4	cefotaxime
25	Albumin Administration in the Prevention of Hepatorenal Syndrome and Death in Patients With Cirrhosis, Bacterial Infections Other Than Spontaneous Bacterial Peritonitis and High Risk of Hospital Mortality	Terminated	NCT02034279	Phase 4	Albumin
26	Clinical, Inflammatory, and Economic Impact of Dextran 70 in Treating Spontaneous Bacterial Peritonitis	Terminated	NCT00570960	Phase 4	Dextran 70
27	Defining the Optimal Duration of Treatment for "Low-Risk" Peritoneal Dialysis-Related Peritonitis	Withdrawn	NCT03675854	Phase 4	Cefazolin
28	Role of Probiotics in the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Randomized Placebo Control Trial	Unknown status	NCT00678613	Phase 2, Phase 3	Probiotics and Placebo;Probiotics and Norfloxacin
29	The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis): a Prospective, Randomized, Placebo-controlled Phase III Study	Unknown status	NCT03688295	Phase 3	Antibiotics
30	Peritonitis Prevention After Insertion of Peritoneal Dialysis Catheter. Comparison Between Post - Surgical Intraperitoneal Vs. Intravenous Pre- Surgical Administration	Unknown status	NCT03046511	Phase 3	Cefazolin
31	Is Spontaneous Bacterial Peritonitis Still Responding to 3rd Generation Cephalosporins?	Unknown status	NCT02443285	Phase 3	Cefotaxime;ceftriaxone
32	Laparoscopic Peritoneal Lavage or Resection for Generalised Peritonitis for Perforated Diverticulitis: a Nationwide Multicenter Randomised Trial	Unknown status	NCT01317485	Phase 3
33	Randomized Control Trial of Rifaximin and Norfloxacin in Primary and Secondary Prophylaxis of Spontaneous Bacterial Peritonitis(SBP) in Cirrhotic Patients	Completed	NCT03695705	Phase 3	Rifaximin 550 mg twice a day and Norfloxacin 400 mg once a day
34	Effects of Intravenous Albumin Administration on Renal Function and Survival in Patients With Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis. A Prospective, Stratified, Randomized and Controlled Study.	Completed	NCT00124228	Phase 3	Human Albumin
35	Evaluation of Safety and Efficacy of Synbiotic on the Incidence and Recurrence of Spontaneous Bacterial Peritonitis in Cirrhotics: A Randomized, Double Blind Placebo Controlled Trial	Completed	NCT00947336	Phase 3	Norfloxacin + Synbiotic;Norfloxacin + Placebo
36	Hartmann vs Resection With Anastomosis and Diverting Stoma for Peritonitis Caused by Perforated Left-sided Colon Diverticulitis: a Multicenter Prospective Randomized Study.	Completed	NCT01239927	Phase 2, Phase 3
37	Effects of Hemoperfusion With a Polymyxin B Membrane in Peritonitis With Septic Shock	Completed	NCT01222663	Phase 3
38	Comparison of Two Durations of Antibiotic Therapy in the Treatment of Severe Postoperative Peritonitis Admitted in Intensive Care Unit: a Randomised Multicentre Study	Completed	NCT01311765	Phase 3
39	SIS Multicenter Study of Duration of Antibiotics for Intraabdominal Infection	Completed	NCT00657566	Phase 3
40	A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections	Completed	NCT00229060	Phase 3	doripenem
41	A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections	Completed	NCT00210938	Phase 3	Doripenem
42	Comparative Study of Rifaximin Versus Norfloxacin in the Secondary Prophylaxis of Spontaneous Bacterial Peritonitis	Recruiting	NCT02120196	Phase 3	Rifaximin;Norfloxacin
43	Primary Prophylaxis for Spontaneous Bacterial Peritonitis in Decompensated Chronic Liver Disease With Small Bowel Bacterial Overgrowth: A Randomised Trial	Recruiting	NCT04775329	Phase 2, Phase 3	Rifaximin
44	Comparative Study Between the Efficacy of Oral Gemifloxacin and Intravenous Cefotaxime in Treatment of Spontaneous Bacterial Peritonitis	Recruiting	NCT04168099	Phase 3	Cefotaxime;Gemifloxacin
45	Comparative Study of Norfloxacin Versus Norfloxacin With Itopride in Secondary Prophylaxis of Spontaneous Bacterial Peritonitis	Recruiting	NCT04161768	Phase 3	Norfloxacin;Itopride
46	Primary Antibiotic Prophylaxis Using Co-trimoxazole to Prevent Spontaneous Bacterial Peritonitis in Cirrhosis	Recruiting	NCT04395365	Phase 3	Co-Trimoxazole 960Mg Dispersible Tablet;Placebo oral tablet
47	The Potential Role of Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis: A Quadruple Blind Clinical Study	Recruiting	NCT05511766	Phase 2, Phase 3	Allopurinol 300 MG;Atorvastatin 20mg;Placebo
48	Rifaximin Versus Norfloxacin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis	Active, not recruiting	NCT04159870	Phase 3	Rifaximin;Norfloxacin
49	A Multicenter, Double-blind, Placebo-controlled Randomized Clinical Trial Comparing Two Strategies of Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Severe Cirrhotic Patients With Ascites : Using or Not Using Rifaximin	Active, not recruiting	NCT03069131	Phase 3	Rifaximin
50	Clinical Study to Evaluate the Possible Efficacy and Safety of Nitazoxanide in Secondary Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients	Not yet recruiting	NCT04746937	Phase 3	Nitazoxanide;Norfloxacin

Search NIH Clinical Center for Peritonitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Albumin Human, USP

ALBUMIN,AGGREGATED

ALBUMIN,EGG

ALBUMIN,HUMAN INJ

ALBUMIN,MICROSPHERE HUMAN SERUM

Cochrane evidence based reviews: peritonitis

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Genetic Tests for Peritonitis

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Anatomical Context for Peritonitis

Organs/tissues related to Peritonitis:

MalaCards : Small Intestine, Liver, Colon, Neutrophil, Kidney, Lung, Bone Marrow

Sources

Publications for Peritonitis

Articles related to Peritonitis:

(show top 50) (show all 31346)

#	Title	Authors	PMID	Year
1	Mortality and risk stratification in patients with Clostridium difficile-associated diarrhoea. ⁵³ ⁶²	Bhangu S...Michael A	19508548	2010
2	Predictors of patient survival in continuous ambulatory peritoneal dialysis: 10-year experience in 2 major centers in Tehran. ⁵³ ⁶²	Hakemi MS...Najafi I	20081304	2010
3	Peritonitis from peg tube insertion in surgical intensive care unit patients: identification of risk factors and clinical outcomes. ⁵³ ⁶²	Shah RD...Janczyk R	19430836	2009
4	AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis. ⁵³ ⁶²	Humpert PM...Bierhaus A	19401390	2009
5	Peritoneal resorption capacity for the inflammatory mediators in acute experimental Staphylococcus aureus peritonitis. ⁵³ ⁶²	Torab FC...Branicki FJ	19669960	2009
6	Primary peritonitis due to brucellosis mimicking tuberculous peritonitis. ⁵³ ⁶²	Demiroglu YZ...Arslan H	19530047	2009
7	Albumin administration in patients with severe sepsis due to secondary peritonitis. ⁵³ ⁶²	Chou CD...Kuo CD	19467947	2009
8	[Peritonitis in the course of peritoneal dialisis caused by Haemophilus influenzae with BLNAR phenotype]. ⁵³ ⁶²	Miklaszewska M...Hryniewicz W	19580200	2009
9	Effect of the combination of fibrin glue and growth hormone on intestinal anastomoses in a pig model of traumatic shock associated with peritonitis. ⁵³ ⁶²	Wang P...Li J	19132439	2009
10	Fungal peritonitis in peritoneal dialysis: risk factors and prognosis. ⁵³ ⁶²	Oygar DD...Serdengecti K	19142806	2009
11	Is decline in serum albumin an ominous sign for subsequent peritonitis in peritoneal dialysis patients? ⁵³ ⁶²	Ozturk S...Bozfakioglu S	19886340	2009
12	Systemic and intraperitoneal proinflammatory cytokine profiles in patients on continuous ambulatory peritoneal dialysis. ⁵³ ⁶²	Maksic D...Bokonjic D	19886317	2009
13	[The prognostic role of interleukin-6 in peritoneal exudate of patients with diffuse peritonitis]. ⁵³ ⁶²	Plotkin LL...Bespalov AM	20020622	2009
14	Clinical characteristics of lower bowel perforation with chronic renal failure. ⁵³ ⁶²	Masuda TA...Masuda H	19102359	2008
15	Concentration of adipokines in peritoneal effluent: a new marker of acute peritonitis in peritoneal dialysis patients? ⁵³ ⁶²	Kolonko A...Wiecek A	18708547	2008
16	The relationship of p1 and lewis antigens with peritoneal dialysis-related Escherichia coli peritonitis. ⁵³ ⁶²	Ting IW...Wu KD	18552251	2008
17	The outcome for pediatric patients on peritoneal dialysis. ⁵³ ⁶²	Acar B...Ekim M	18587728	2008
18	TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis. ⁵³ ⁶²	Leendertse M...van der Poll T	18354210	2008
19	[Peritonitis related to peritoneal dialysis: evaluation of 179 attacks]. ⁵³ ⁶²	Naz H...Yalcin AU	18697424	2008
20	Relation of demographic, clinic and biochemical parameters to peritonitis in peritoneal dialysis. ⁵³ ⁶²	Dogan S...Kazancioglu R	18336516	2008
21	Fas expression on peritoneal macrophages during continuous ambulatory peritoneal dialysis peritonitis. ⁵³ ⁶²	Chen CY...Chiang HC	18350449	2008
22	Proteomic analysis of peritoneal dialysate fluid in patients with dialysis-related peritonitis. ⁵³ ⁶²	Lin WT...Wu YJ	18791950	2008
23	A leptin serum concentration less than 10 ng/ml is a predictive marker of outcome in patients with moderate to severe secondary peritonitis. ⁵³ ⁶²	Bracho-Riquelme RL...Flores-Garcia AI	18525209	2008
24	Streptococcus salivarius bacteremia and spontaneous bacterial peritonitis in liver transplantation candidates. ⁵³ ⁶²	Gautam M...Kusne S	17969206	2007
25	Reduced residual renal function is a risk of peritonitis in continuous ambulatory peritoneal dialysis patients. ⁵³ ⁶²	Han SH...Han DS	17517797	2007
26	Influence of peritoneal dialysis training nurses' experience on peritonitis rates. ⁵³ ⁶²	Chow KM...Kam-Tao Li P	17699477	2007
27	Peritonitis, peritoneal inflammation and membrane permeability: a longitudinal study of dialysate and serum MCP-1 in stable patients on peritoneal dialysis. ⁵³ ⁶²	Malik AR...Brown EA	17557268	2007
28	Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis. ⁵³ ⁶²	Hastbacka J...Lauhio A	17224788	2007
29	Adherence to peritoneal dialysis training schedule. ⁵³ ⁶²	Chow KM...Li PK	17035375	2007
30	Comparison of incidence of peritonitis between peritoneal dialysis solution types. ⁵³ ⁶²	Duranay M...Akcay A	17409770	2007
31	Systemic and intraperitoneal proinflammatory cytokines profiles in patients on chronic peritoneal dialysis. ⁵³ ⁶²	Maksic D...Bokonjic D	18928158	2007
32	Impact of nutritional status on peritonitis in CAPD patients. ⁵³ ⁶²	Prasad N...Kumar R	17179509	2007
33	Clinical predictors of ongoing infection in secondary peritonitis: systematic review. ⁵³ ⁶²	Lamme B...Boermeester MA	17102920	2006
34	Malnutrition-inflammation score is a useful tool in peritoneal dialysis patients. ⁵³ ⁶²	Afsar B...Haberal M	17047239	2006
35	Anti-inflammatory effects of a novel peptide designed to bind with NF-kappaB p50 subunit. ⁵³ ⁶²	Wang ZP...Liang HP	17049124	2006
36	Compartmentalization of interleukin-6 response in a patient with septic meningococcal peritonitis. ⁵³ ⁶²	de Souza AL...Seguro AC	16988004	2006
37	Survival and technical failure in a large cohort of Thai CAPD patients. ⁵³ ⁶²	Pongskul C...Limwatananon C	17044460	2006
38	Risk factors of first peritonitis episode in Thai CAPD patients. ⁵³ ⁶²	Sirivongs D...Johns J	17044465	2006
39	Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation. ⁵³ ⁶²	Rogachev B...Douvdevani A	16788688	2006
40	Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils. ⁵³ ⁶²	Terakawa M...Fukuda Y	16690053	2006
41	Peritonitis in childhood: clinical relevance of cytokines in the peritoneal exudate. ⁵³ ⁶²	Haecker FM...von Schweinitz D	16685614	2006
42	Timely transfer of peritoneal dialysis patients to hemodialysis improves survival rates. ⁵³ ⁶²	Panagoutsos S...Vargemezis V	16429841	2006
43	Systemic and intraperitoneal interleukin-6 system during the first year of peritoneal dialysis. ⁵³ ⁶²	Pecoits-Filho R...Heimburger O	16538876	2006
44	Dialysate CA125 levels in children on continuous peritoneal dialysis. ⁵³ ⁶²	Turhan P...Arisoy N	16133054	2005
45	The impact of topical mupirocin on peritoneal dialysis infection in Singapore General Hospital. ⁵³ ⁶²	Lim CT...Foo MW	16046516	2005
46	Risk factors for peritonitis in pediatric peritoneal dialysis: a single-center study. ⁵³ ⁶²	Boehm M...Arbeiter K	16082548	2005
47	[A contemporary situation in the antimicrobial treatment of the secondary peritonitis]. ⁵³ ⁶²	Vyhnanek F...Vrankova J	16250620	2005
48	The impact of topical mupirocin on peritoneal dialysis infection rates in Singapore General Hospital. ⁵³ ⁶²	Lim CT...Foo MW	15855200	2005
49	A risk analysis of continuous ambulatory peritoneal dialysis-related peritonitis. ⁵³ ⁶²	Chow KM...Li PK	16022095	2005
50	IL-6 transsignaling: the in vivo consequences. ⁵³ ⁶²	Jones SA...Rose-John S	15871661	2005

Sources

Genes for Peritonitis

Genes related to Peritonitis (0 elite genes):

(show all 45)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TMEM67	Transmembrane Protein 67	Protein Coding	25	Likely pathogenic ⁵
2	ALB	Albumin	Protein Coding	24.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19886340 12612991 18336516 (more) 8781999 19467947 10406577 9580052 8399604 16022095 12185481 12407651 1904174 16046516 10635535 11510267 10594200 15855200 2096925 1361820 8413793 18697424 19401390 9810781 17409770 17179509 9100681 8418622 1361799 17517797 17035375 16429841 10789189 2051726 19508548 19430836 19102359 17102920 17044465 17044460 14563190 14524123 16244470 16082548 12455568 9323505 8215734 11837174 11216572 1420492 2268489 19142806 14991977 10804342 9857705 18587728 12402612 10481882 2086319 17969206 17047239 12026517 20081304 2085582 19917360 18552251 17699477 9655152 7999872 8863326
3	IL6	Interleukin 6	Protein Coding	22.24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8459875 19669960 11510267 (more) 15297786 2077410 10708179 7816257 1630534 8372840 18525209 11583955 8245688 9137991 7591361 8887280 7745108 1551256 12022754 1509242 12812261 11471666 1816119 18928158 16685614 14515143 10824456 10023645 9102882 19886317 18708547 16988004 12006934 9568859 8433563 1914167 19132439 15708102 20020622 12623511 15871661 16788688 12402613 16538876 17049124
4	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	19.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9132652 8534702 8959628 (more) 17557268 12022754 10649717 9641170
5	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	19.34	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15614130 11231849 11755216 (more) 11303726
6	MUC16	Mucin 16, Cell Surface Associated	Protein Coding	17.7	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16133054 10682069 11783764 (more) 7963890 10682070 7692953
7	ADA	Adenosine Deaminase	Protein Coding	17	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1452564 15560383 9015506 (more) 19530047
8	B2M	Beta-2-Microglobulin	Protein Coding	16.88	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2174686 1982784 18791950 (more) 10682119 7612733 2403753
9	TLR2	Toll Like Receptor 2	Protein Coding	16.84	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18354210
10	LBP	Lipopolysaccharide Binding Protein	Protein Coding	16.6	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9360683 9568859 9695742 (more) 11739189 7520106
11	TNF	Tumor Necrosis Factor	Protein Coding	16.48	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	CRP	C-Reactive Protein	Protein Coding	16.19	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	IL1B	Interleukin 1 Beta	Protein Coding	16.17	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	15.5	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	IL10	Interleukin 10	Protein Coding	15.47	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	AQP1	Aquaporin 1 (Colton Blood Group)	Protein Coding	15.45	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10505696 9688919
17	ITGB2	Integrin Subunit Beta 2	Protein Coding	15.42	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15119634
18	F2	Coagulation Factor II, Thrombin	Protein Coding	15.14	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
19	ITGAM	Integrin Subunit Alpha M	Protein Coding	15.13	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	15.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12145553
21	FCGR3B	Fc Gamma Receptor IIIb	Protein Coding	14.99	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12145553
22	CTSG	Cathepsin G	Protein Coding	14.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2222858
23	PRTN3	Proteinase 3	Protein Coding	14.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1708522
24	TLR4	Toll Like Receptor 4	Protein Coding	14.91	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
25	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	14.79	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
26	MEFV	MEFV Innate Immunity Regulator, Pyrin	Protein Coding	14.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10709887
27	CD14	CD14 Molecule	Protein Coding	14.61	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9695742 18354210
28	CD69	CD69 Molecule	Protein Coding	14.51	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12402613 18350449
29	MPO	Myeloperoxidase	Protein Coding	14.41	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
30	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	14.24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12145553
31	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	14.21	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
32	MMP8	Matrix Metallopeptidase 8	Protein Coding	14.1	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17224788
33	SELP	Selectin P	Protein Coding	14.09	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
34	ELANE	Elastase, Neutrophil Expressed	Protein Coding	14.08	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
35	IL18	Interleukin 18	Protein Coding	14.07	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
36	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	14.07	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
37	IL17A	Interleukin 17A	Protein Coding	14.04	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
38	CMA1	Chymase 1	Protein Coding	14.04	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16690053
39	SELL	Selectin L	Protein Coding	13.99	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
40	LCN2	Lipocalin 2	Protein Coding	13.88	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
41	HMGB1	High Mobility Group Box 1	Protein Coding	13.87	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
42	IFNG	Interferon Gamma	Protein Coding	13.87	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
43	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	13.87	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
44	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	13.82	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
45	CSF3	Colony Stimulating Factor 3	Protein Coding	13.76	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)

Sources

Variations for Peritonitis

ClinVar genetic disease variations for Peritonitis:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	TMEM67	NM_153704.6(TMEM67):c.1321C>T (p.Arg441Cys)	SNV	Likely Pathogenic	217725	rs752362727	GRCh37: 8:94798483-94798483 GRCh38: 8:93786255-93786255
2	TMEM67	NM_153704.6(TMEM67):c.1843T>C (p.Cys615Arg)	SNV	Likely Pathogenic	1383	rs201893408	GRCh37: 8:94808198-94808198 GRCh38: 8:93795970-93795970

Sources

Expression for Peritonitis

Search GEO for disease gene expression data for Peritonitis.

Sources

Pathways for Peritonitis

Pathways related to Peritonitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.89	B2M CCL2 CRP CXCL2 CXCL8 F2
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.85	TNF ITGB2 ITGAM IL6 IL1B IL10
3	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.59	CCL2 CXCL8 F2 IL10 IL1B IL6
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.48	CCL2 CXCL2 CXCL8 IL10 IL1B IL6
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.34	TNF IL6 IL1B IL10 CXCL8 CXCL2
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.23	B2M CCL2 CXCL2 CXCL8 FCGR1A IL10
7	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.91	TNF TLR2 LBP IL6 IL1B CXCL8
8	Malignant pleural mesothelioma ⁷⁴	12.74	ITGB2 IL6 IL1B IL10 CCL2
9	Complement cascade ⁶⁶ Show member pathways Activation of C3 and C5 ⁶⁶ Classical Complement Pathway ⁶⁴ Complement Pathway ⁶⁴ Complement system ⁷⁴ Complement system in neuronal development and plasticity ⁷⁴ Lectin Induced Complement Pathway ⁶⁴ Regulation of Complement cascade ⁶⁶	12.71	TLR2 ITGB2 ITGAM F2 CRP ALB
10	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.67	TNF TLR2 IL6 IL1B CXCL8
11	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.67	TNF IL6 IL1B IL10 F2 CCL2
12	NF-kappaB Signaling ³	12.63	TNF TLR2 ITGB2 IL1B IL10 CCL2
13	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.59	TNF TLR2 IL6 IL1B CXCL8
14	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.52	TNF TLR2 LBP IL6 IL1B CXCL8
15	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.39	TNF LBP IL6 IL1B CXCL8
16	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.37	TNF TLR2 IL6 CXCL8 CXCL2 CCL2
17	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.26	TNF IL6 IL1B IL10 CXCL8
18	Neuroinflammation and glutamatergic signaling ⁷⁴	12.16	TNF IL6 IL1B IL10
19	Integrin family cell surface interactions ⁶¹ Show member pathways Phagocytosis of Microbes ⁶⁴ Plexin-D1 Signaling ⁶¹	12.14	TLR2 ITGB2 ITGAM FCGR1A
20	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.07	TNF ITGAM IL6 IL10
21	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	12.03	TNF TLR2 IL6 IL1B IL10
22	CCL18 signaling pathway ⁷⁴	12	ITGB2 IL6 IL10 CXCL8 CCL2
23	Allograft rejection ⁷⁴	11.96	TNF IL1B IL10 CXCL8
24	Spinal cord injury ⁷⁴	11.93	TNF IL6 IL1B CXCL8 CXCL2 CCL2
25	Innate Lymphoid Cells Differentiation ⁶⁵	11.89	TNF ITGAM IL1B IL10
26	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.88	CCL2 CRP CXCL8 IL6 LBP
27	Burn wound healing ⁷⁴	11.86	TNF IL6 IL1B CXCL8 CCL2
28	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.84	TNF ITGAM IL6 IL1B IL10
29	AP-1 transcription factor network ⁶¹	11.82	IL6 IL10 CXCL8 CCL2
30	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.81	CRP IL10 IL6 ITGB2 TNF
31	Microglia pathogen phagocytosis pathway ⁷⁴ Show member pathways GPVI-mediated activation cascade ⁶⁶	11.79	ITGB2 ITGAM FCGR1A
32	Acute viral myocarditis ⁷⁴	11.78	ITGB2 IL6 IL10
33	IL 10 signaling pathway ⁶⁷	11.77	IL10 IL1B IL6 TNF
34	miRNAs involvement in the immune response in sepsis ⁷⁴	11.76	CXCL8 IL10 IL6 TNF
35	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.73	TNF TLR2 IL6 IL10
36	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.73	TNF IL6 IL1B CXCL8 CXCL2
37	Lung fibrosis ⁷⁴	11.68	TNF IL6 IL1B CXCL8 CXCL2 CCL2
38	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.66	TNF IL6 CXCL8 CCL2
39	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.63	TNF IL10 CXCL8 CXCL2 CCL2
40	Netrin-UNC5B signaling pathway ⁷⁴	11.62	TNF IL10 CCL2
41	Nonalcoholic fatty liver disease ⁷⁴	11.56	TNF IL6 CCL2
42	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.55	TNF IL6 IL1B
43	IL6-mediated signaling events ⁶¹	11.55	LBP IL6 CRP
44	Immune response_Role of integrins in NK cells cytotoxicity ²²	11.54	CXCL8 ITGAM ITGB2
45	IL-10 Pathway ⁶⁴	11.49	TNF IL6 IL1B IL10
46	Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction ⁶⁰	11.46	IL10 FCGR1A F2
47	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ⁶¹	11.43	IL6 CXCL8 CCL2
48	MSP-RON Signaling ⁶⁴	11.42	TNF TLR2 ITGB2 ITGAM IL1B CCL2
49	Development and heterogeneity of the ILC family ⁷⁴	11.39	TNF IL6 IL1B
50	amb2 Integrin signaling ⁶¹	11.38	TNF ITGB2 ITGAM IL6

Sources

GO Terms for Peritonitis

Cellular components related to Peritonitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	10.13	TNF TLR2 LBP ITGB2 ITGAM B2M
2	extracellular region	GO:0005576	10.05	ALB B2M CCL2 CRP CXCL2 CXCL8
3	external side of plasma membrane	GO:0009897	10	ADA B2M F2 FCGR1A ITGAM ITGB2
4	extracellular space	GO:0005615	9.75	TNF MUC16 LBP ITGAM IL6 IL1B
5	integrin alphaM-beta2 complex	GO:0034688	9.56	ITGB2 ITGAM

Biological processes related to Peritonitis according to GeneCards Suite gene sharing:

(show all 40)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell population proliferation	GO:0008285	10.41	CXCL8 IL10 IL1B IL6 TLR2 TNF
2	inflammatory response	GO:0006954	10.28	CCL2 CRP CXCL2 CXCL8 IL1B IL6
3	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.27	TNF IL6 IL1B IL10
4	positive regulation of interleukin-6 production	GO:0032755	10.24	IL1B IL6 LBP TLR2 TNF
5	positive regulation of NF-kappaB transcription factor activity	GO:0051092	10.21	TNF TLR2 ITGB2 IL6 IL1B
6	defense response to Gram-positive bacterium	GO:0050830	10.21	TNF TLR2 LBP IL6 IL1B CRP
7	positive regulation of interleukin-8 production	GO:0032757	10.16	IL1B IL6 LBP TLR2 TNF
8	acute-phase response	GO:0006953	10.15	LBP IL6 F2 CRP
9	response to lipopolysaccharide	GO:0032496	10.14	TNF TLR2 LBP IL1B IL10
10	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.13	TNF IL6 IL10 F2
11	liver regeneration	GO:0097421	10.12	TNF IL6 IL10
12	positive regulation of superoxide anion generation	GO:0032930	10.1	CRP ITGAM ITGB2
13	microglial cell activation	GO:0001774	10.1	TNF TLR2 ITGB2 ITGAM
14	positive regulation of glial cell proliferation	GO:0060252	10.09	TNF IL6 IL1B
15	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.08	TNF ITGB2 IL1B
16	embryonic digestive tract development	GO:0048566	10.08	TNF CXCL8 ADA
17	negative regulation of neurogenesis	GO:0050768	10.08	TNF IL6 IL1B B2M
18	positive regulation of heterotypic cell-cell adhesion	GO:0034116	10.07	IL10 IL1B TNF
19	lipopolysaccharide-mediated signaling pathway	GO:0031663	10.07	CCL2 IL1B LBP TLR2 TNF
20	positive regulation of T cell activation	GO:0050870	10.06	CCL2 B2M ADA
21	positive regulation of chemokine production	GO:0032722	10.06	TNF TLR2 LBP IL6 IL1B
22	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	10.05	TNF ITGB2 IL6
23	positive regulation of neuroinflammatory response	GO:0150078	10.04	TNF IL6 IL1B
24	negative regulation of lipid storage	GO:0010888	10.03	TNF IL6 CRP
25	neutrophil chemotaxis	GO:0030593	10.03	LBP ITGB2 IL1B CXCL8 CXCL2 CCL2
26	vascular endothelial growth factor production	GO:0010573	9.99	TNF IL6 IL1B
27	negative regulation of cytokine production involved in immune response	GO:0002719	9.98	TNF IL10
28	positive regulation of fever generation	GO:0031622	9.98	TNF IL1B
29	immune response	GO:0006955	9.97	B2M CCL2 CXCL2 CXCL8 FCGR1A IL10
30	sequestering of triglyceride	GO:0030730	9.96	IL1B TNF
31	positive regulation of neutrophil degranulation	GO:0043315	9.96	ITGAM ITGB2
32	leukocyte migration	GO:0050900	9.95	TNF IL1B ADA
33	positive regulation of prostaglandin-E synthase activity	GO:2000363	9.94	ITGB2 ITGAM
34	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.94	TNF IL1B
35	negative regulation of dopamine metabolic process	GO:0045963	9.93	ITGB2 ITGAM
36	chronic inflammatory response to antigenic stimulus	GO:0002439	9.93	TNF IL10
37	cellular response to lipopolysaccharide	GO:0071222	9.83	TNF LBP IL6 IL1B IL10 CXCL8
38	response to external stimulus	GO:0009605	9.76	TLR2 CXCL8 CXCL2
39	cellular extravasation	GO:0045123	9.65	ITGB2 TNF
40	response to molecule of bacterial origin	GO:0002237	9.28	TLR2 IL10 CXCL8 CXCL2 B2M