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MCID: PRT036
MIFTS: 64

Peritonitis

Categories: Endocrine diseases, Gastrointestinal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Peritonitis

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MalaCards integrated aliases for Peritonitis:

Name: Peritonitis 12 74 54 6 15 17 71 32
Retractile Mesenteritis 12 52 71
Sclerosing Mesenteritis 12 52 71
Peritoneal Retractile Mesenteritis 52 71
Acute Generalized Peritonitis 12 71
Primary Bacterial Peritonitis 12 71
Mesenteric Panniculitis 52 71
Idiopathic Sclerosing Mesenteritis 52
Liposclerotic Mesenteritis 52
Mesenteric Lipodystrophy 52
Mesenteric Lipogranuloma 52
Mesenteric Fibromatosis 52
Fibromatosis, Abdominal 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8283
ICD9CM 34 567.8
ICD10 32 K65 K65.9
UMLS 71 C0025470 C0029823 C0031154 more
Sources

Summaries for Peritonitis

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NIH Rare Diseases : 52 Sclerosing mesenteritis is one of many terms that describes a spectrum of inflammatory disorders that affect the mesentery. The mesentery is the membrane that anchors the small intestine to the back of the abdominal wall. The condition mostly affects men between their 40s and 60s, but women and children can also be affected. It may result in a variety of symptoms including abdominal pain, nausea and vomiting, constipation or diarrhea, weight loss, and fever. Some people have an abdominal mass. The cause of the condition is poorly understood. Suggested possible causes have included previous abdominal surgery or trauma, autoimmunity , paraneoplastic syndromes , ischemic injury , and infection. Treatment depends on the symptoms in each person and may include the use of glucocorticoids , hormonal therapy (tamoxifen or progesterone ), or other medications, either alone or in combination (i.e. glucocorticoids in combination with tamoxifen). Surgery may be needed for an obstruction, if present. Although there are case reports of patients with aggressive disease and fatalities, it appears that the condition usually remains stable or is slowly progessive. In some cases, the condition goes away on its own.

MalaCards based summary : Peritonitis, also known as retractile mesenteritis, is related to primary peritoneal carcinoma and tuberculous peritonitis. An important gene associated with Peritonitis is TMEM67 (Transmembrane Protein 67), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Sargramostim and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and neutrophil, and related phenotypes are cardiovascular system and cellular

Disease Ontology : 12 A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. Peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. The symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output.

Wikipedia : 74 Peritonitis is inflammation of the peritoneum, the lining of the inner wall of the abdomen and cover of... more...

Sources

Related Diseases for Peritonitis

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Diseases related to Peritonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2177)
# Related Disease Score Top Affiliating Genes
1 primary peritoneal carcinoma 35.1 MUC16 IL10 CXCL8
2 tuberculous peritonitis 34.8 MUC16 CRP ALB ADA
3 appendicitis 33.6 TNF LBP IL6 IL1B IL10 CXCL8
4 endometriosis 33.3 MUC16 IL6 IL1B CXCL8 CCL2
5 intussusception 33.2 IL6 CRP ALB
6 systemic onset juvenile idiopathic arthritis 33.2 TNF IL1B
7 familial mediterranean fever 33.2 TNF TLR2 MEFV IL6 IL1B IL10
8 ascaris lumbricoides infection 33.1 IL6 IL1B IL10 CXCL8
9 juvenile arthritis 33.1 IL6 IL10 CXCL8 CRP
10 amebiasis 32.8 TNF TLR2 IL1B CXCL8 ALB
11 end stage renal disease 32.6 TNF IL6 CRP ALB
12 intestinal obstruction 32.1 TNF IL6 CRP ALB
13 kidney disease 32.1 TMEM67 IL6 CRP CCL2 B2M ALB
14 diverticulitis 31.9 TNF IL6 CRP ALB
15 intestinal perforation 31.8 TNF IL6 CRP ALB
16 uremia 31.8 TNF ITGAM IL6 CRP B2M ALB
17 ileus 31.8 TNF IL6 IL1B IL10 CRP CCL2
18 glomerulonephritis 31.7 IL1B CCL2 B2M ALB
19 congestive heart failure 31.7 TNF IL6 IL1B CRP ALB
20 chronic kidney disease 31.6 TNF IL6 IL1B IL10 CRP CCL2
21 acute pancreatitis 31.5 TNF IL6 IL1B IL10 CXCL8 CRP
22 liver disease 31.5 TNF IL6 IL1B CXCL8 ALB
23 peripheral vascular disease 31.5 IL6 CRP CCL2 ALB
24 pancreatitis 31.5 TNF TMEM67 IL6 IL1B IL10 CRP
25 typhoid fever 31.4 TNF IL6 IL1B CRP ALB
26 echinococcosis 31.4 TNF TLR2 IL6 IL10
27 constipation 31.4 TNF IL6 CRP ALB
28 neutropenia 31.4 TNF ITGAM IL6 IL1B IL10 CXCL8
29 duodenal ulcer 31.4 TNF IL6 IL1B IL10 CXCL8
30 peptic ulcer disease 31.3 TNF IL1B IL10 CXCL8 ALB
31 abdominal tuberculosis 31.3 TNF CRP ALB ADA
32 vascular disease 31.3 TNF ITGAM IL6 IL10 CRP CCL2
33 gastric adenocarcinoma 31.3 TNF MUC16 IL6 IL1B CXCL8 CRP
34 volvulus of midgut 31.3 TLR2 CRP ALB
35 intestinal tuberculosis 31.3 TNF CRP ALB
36 hepatic encephalopathy 31.3 TNF IL6 ALB
37 deficiency anemia 31.3 TNF IL6 CRP ALB
38 neutrophil migration 31.3 ITGB2 ITGAM CXCL8
39 compartment syndrome 31.2 TNF IL6 CRP ALB
40 bone disease 31.2 TNF IL6 IL1B CXCL8 CCL2 B2M
41 salpingitis 31.2 TNF TLR2 CRP
42 gastric ulcer 31.2 TNF IL6 IL1B CXCL8
43 fasciitis 31.2 TNF IL6 CXCL8 CRP
44 intracranial hypertension 31.2 TNF IL1B AQP1 ALB
45 protein-energy malnutrition 31.2 TNF IL6 ALB
46 pleural empyema 31.2 CRP ALB ADA
47 disseminated intravascular coagulation 31.2 TNF IL6 IL10 CRP
48 respiratory failure 31.2 TNF IL6 IL1B IL10 CXCL8 CRP
49 cellulitis 31.2 TNF IL6 IL1B IL10 CRP
50 mycobacterium tuberculosis 1 31.1 TNF TLR2 ITGAM IL10 CRP ADA

Comorbidity relations with Peritonitis via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Intestinal Perforation Paralytic Ileus
Protein-Energy Malnutrition Respiratory Failure

Graphical network of the top 20 diseases related to Peritonitis:



Diseases related to Peritonitis
Sources

Symptoms & Phenotypes for Peritonitis

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MGI Mouse Phenotypes related to Peritonitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 ADA ALB AQP1 B2M CRP CXCL2
2 cellular MP:0005384 10.21 ADA ALB B2M FCGR1A IL10 IL6
3 hematopoietic system MP:0005397 10.18 ADA AQP1 B2M FCGR1A IL10 IL1B
4 homeostasis/metabolism MP:0005376 10.17 ADA ALB AQP1 B2M CRP IL10
5 immune system MP:0005387 10.13 ADA ALB B2M CCL2 CRP FCGR1A
6 digestive/alimentary MP:0005381 10.01 ADA ALB B2M IL10 IL6 TLR2
7 liver/biliary system MP:0005370 9.85 ADA ALB B2M IL10 IL6 LBP
8 neoplasm MP:0002006 9.5 ALB B2M IL10 IL1B IL6 TLR2
9 skeleton MP:0005390 9.4 ADA AQP1 CXCL2 FCGR1A IL10 IL1B
Sources

Drugs & Therapeutics for Peritonitis

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Drugs for Peritonitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 264)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sargramostim Approved, Investigational Phase 4 83869-56-1, 123774-72-1
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
4
Lenograstim Approved, Investigational Phase 4 135968-09-1
5
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
6
Cefoxitin Approved Phase 4 35607-66-0 441199
7
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
8
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
9
Tigecycline Approved Phase 4 220620-09-7 5282044
10
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
11
Micafungin Approved, Investigational Phase 4 235114-32-6 477468 3081921
12
Sulbactam Approved Phase 4 68373-14-8
13
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
14
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
15
Sultamicillin Approved, Investigational Phase 4 76497-13-7
16
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
17
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
18
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
19
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
20
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
21
Teicoplanin Approved, Investigational Phase 4 61036-62-2
22
Lisinopril Approved, Investigational Phase 4 76547-98-3, 83915-83-7 5362119
23
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
24
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
25
Propranolol Approved, Investigational Phase 4 525-66-6 4946
26
Atorvastatin Approved Phase 4 134523-00-5 60823
27
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
28
Ceftriaxone Approved Phase 4 73384-59-5 5361919 5479530
29
tannic acid Approved Phase 4 1401-55-4
30
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
31
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
32
Losartan Approved Phase 4 114798-26-4 3961
33
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
34
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
35
Ornithine Approved, Nutraceutical Phase 4 70-26-8, 3184-13-2 6262
36
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
37
Valine Approved, Nutraceutical Phase 4 72-18-4 6287
38 Respiratory System Agents Phase 4
39 Antidotes Phase 4
40 Expectorants Phase 4
41 N-monoacetylcystine Phase 4
42 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
43 Cyclosporins Phase 4
44 Ferric Oxide, Saccharated Phase 4
45 Iron Supplement Phase 4
46 Gentamicins Phase 4
47 Antioxidants Phase 4
48 Protective Agents Phase 4
49 Gastrointestinal Agents Phase 4
50 Echinocandins Phase 4

Interventional clinical trials:

(show top 50) (show all 380)
# Name Status NCT ID Phase Drugs
1 The Clinical Use of Probiotics in the Uremia Patients Under Chronic Peritoneal Dialysis Unknown status NCT01076426 Phase 4 Pro-biotics
2 PROPHYlactic Implantation of BIOlogic Mesh in Peritonitis (PROPHYBIOM) Unknown status NCT02277262 Phase 4
3 Antibiotics vs.Surgery in Acute Appendicitis;an Intention to Treat Prospective Randomised Study. The ASAA-study Unknown status NCT01421901 Phase 4 Ertapenem
4 A Randomized Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis Unknown status NCT00761098 Phase 4 Standard Care;Experimental
5 Study of Safety, Immunogenicity and Immunological Memory of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome Unknown status NCT01346007 Phase 4
6 Prospective, Randomized, Open-Label Study of Topical Antibiotic Prophylaxis at the Catheter Exit Site: Continuous Daily Gentamicin Cream Versus Cyclical Gentamicin Cream and Mupirocin 2% Cream Alternating at Monthly Basis. Unknown status NCT00751374 Phase 4 gentamicin;gentamicin cream alternating with mupirocin cream
7 Randomized, Parallel Group, Clinical Trial Comparing Intravenous Iron Sucrose Versus Oral Ferrous Sulphate in the Treatment of Perioperative Iron Deficiency in Patients With Colo-Rectal Neoplasm and Iron Deficiency Anemia. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
8 An Open-Lable Multicenter Prospective Non-Randomized Trial to Assess the Efficacy and Safety of Morinidazole With Levofloxacin and Sequential of Levofloxacin in Women With Pelvic Inflammatory Disease Unknown status NCT03391440 Phase 4 morinidazole
9 Granulocyte Colony Stimulating Factor Plus N-Acetyl Cysteine In Severe Alcoholic Hepatitis Unknown status NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
10 Prophylactic Administration of Antibiotics Before Radiofrequency Ablation for Hepatocellular Carcinoma: A Randomized Trial Unknown status NCT02534961 Phase 4 Cefazolin
11 Effect of Icodextrin on the Treatment Outcome of Peritoneal Dialysis Patients Completed NCT01044446 Phase 4 Icodextrin;glucose-based peritoneal dialysate
12 Bacteria Endotoxin in Peritoneal Dialysis Effluent as a Predictor of Relapsing, Recurrent, and Repeat Peritonitis Completed NCT01817309 Phase 4
13 Randomized Trial on Intravenous Antibiotics With Adjunctive Lavage for Severe Peritoneal-dialysis Related Peritonitis Completed NCT02926846 Phase 4 Intravenous vancomycin & gentamicin with adjunctive lavage;Intraperitoneal vancomycin & gentamicin
14 Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis Completed NCT02805049 Phase 4 Echinocandins
15 The Efficacy of Prolonged Antibiotic Therapy for the Prevention of Relapsing Peritonitis in Peritoneal Dialysis Patients With High Dialysis Effluent Bacterial DNA Fragment Levels Completed NCT02593201 Phase 4 Extended antibiotics (cefazolin or ceftazidime);Usual antibiotics (cefazolin or ceftazidime)
16 Randomized Controlled Trial Comparing Residual Kidney Function in Patients Undergoing Three or Four Exchanges CAPD Completed NCT01637792 Phase 4
17 A Randomized Controlled Double Blind Study Using Mupirocin Versus Polysporin Triple for the Prevention of Catheter-related Infections in Patients Treated With Peritoneal Dialysis Completed NCT00400595 Phase 4 Mupirocin ointment;Polysporin Triple
18 Randomized Double-Blid Placebo Controlled Trial Assessing Norfloxacin In The Primary Prophylaxis Of Spontaneous Bacterial Peritonitis In Advanced Cirrhosis Completed NCT00359853 Phase 4 Oral norfloxacin
19 A Randomized, Multi-Center, Open Label Trial to Establish the Equivalence Between ANDY-Disc® (Fresenius Medical Care) and Ultrabag® (Baxter) in Patients on CAPD. [CAPD-2 Trial] Completed NCT00255619 Phase 4
20 A Multicenter, Randomized, Controlled Trial Comparing Cefepime Monotherapy Versus Combination of Cefazolin Plus Ceftazidime for Empirical Treatment of CAPD-associated Peritonitis Completed NCT02872038 Phase 4 Cefepime;Cefazolin plus Ceftazidime
21 Phase 4 Study of Primary Use of the Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis Completed NCT01531543 Phase 4
22 Comparison of Efficacy of Cefotaxime, Ceftriaxone, and Ciprofloxacin for the Treatment of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis Completed NCT01265173 Phase 4 Cefotaxime;Ceftriaxone;Ciprofloxacin
23 Multicenter, Randomized, Double-blind, Placebo-controlled Study on the Effectiveness of Treatment With Beta-blockers to Prevent Decompensation of Cirrhosis With Portal Hypertension Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
24 Comparison of Daily Norfloxacin Versus Weekly Ciprofloxacin for the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients Completed NCT01542801 Phase 4 Norfloxacin;ciprofloxacin
25 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
26 Open-label, Randomized, Controlled, With Blind Assessor, Study to Assess Efficacy and Safety of Rheosorbilact®, Solution for Infusion, in Comparison With Ringer's Lactate,Solution for Infusion, in a Complex Therapy of Peritonitis. Completed NCT03771170 Phase 4 Rheosorbilact®;Ringer lactate
27 A Prospective, Double-blind, Multi Center, Randomized Clinical Study to Compare the Efficacy and Safety of Ertapenem 3 Days Versus Ampicillin-Sulbactam 3 Days in the Treatment of Localized Community Acquired Intra-abdominal Infection (IAI). (T.E.A. Study Three Days Ertapenem vs Three Days Ampicillin- Sulbactam) Completed NCT00630513 Phase 4 Ertapenem;Ampicillin-Sulbactam
28 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
29 Randomized, Long-Term Administration of pH-Neutral PD Solutions Containing Lactate (BALANCE) or Bicarbonate (BICAVERA) in Children Completed NCT01632046 Phase 4 lactate and bicarbonate buffered dialysis solutions
30 Effects of the Administration of Albumin in Patients With Cirrhosis and Acute Hepatic Encephalopathy. Completed NCT00886925 Phase 4 Albumin;Sodium chloride 0.9%
31 Beneficial Effect of Probiotics on Chronic Kidney Disease Completed NCT01391468 Phase 4
32 A Randomized Trial of Daily Chlorhexidine Care at the Exit Site in Peritoneal Dialysis Patients for Bacterial Decolonization and Prevention of Infection Completed NCT02446158 Phase 4 Chlorhexidine gluconate
33 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy Due to Acute Cholecystitis. Is it Necessary? Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
34 Effect of Dexmedetomidine on Mortality, Duration of Mechanical Ventilation and Multi-organ Function in Sepsis Patients Under Lighter Sedation by Randomized Control Trial Completed NCT01760967 Phase 4 Dexmedetomidine
35 Evaluation of Intravenous and Intraperitoneal Pharmacokinetics of Dalbavancin in Peritoneal Dialysis Patients Completed NCT02940730 Phase 4 Dalbavancin via Intravenous Administration;Dalbavancin via Intraperitoneal Administration
36 The Clinical Effects of Korean Adapted APD in Automated Peritoneal Dialysis Patients Completed NCT01997385 Phase 4
37 Omega-3 Fatty Acids and Postoperative Complication After Colorectal Surgery Completed NCT00488904 Phase 4
38 Non Operative Treatment for Acute Appendicitis: Study on Efficacy and Safety of Antibiotic Treatment (Amoxicillin and Clavulanic Acid) in Patients With Right Sided Lower Abdominal Pain Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
39 Intestinal Decontamination With Rifaximin. Effects on the Inflammatory and Circulatory State in Patients With Cirrhosis and Ascites - A Randomised Controlled Clinical Study Completed NCT01769040 Phase 4 Rifaximin;placebo
40 Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis in Patients With Acute Variceal Bleeding Completed NCT00838864 Phase 4 ceftrioxone;ceftrioxone
41 Efficacy and Safety of a Very Low Protein Diet in Postponing Dialysis in Elderly: a Prospective Randomized Multicenter Controlled Study Completed NCT00388648 Phase 4 mixture of amino and keto acids
42 Prospective, Randomised European Multicentric Study, Comparing Enteral Stent Followed by Elective Surgery Versus Emergency Surgical Treatment in Malignant Colonic Obstruction Completed NCT00591695 Phase 4
43 Effects of Angiotensin Converting Enzyme Inhibitors on Peritoneal Protein Loss and Solute Transport in Peritoneal Dialysis Patients Completed NCT01575652 Phase 4
44 The Use of Human Albumin for the Treatment of Ascites in Patients With Hepatic Cirrhosis: a Multicenter, Open-label Randomized Clinical Trial Completed NCT01288794 Phase 4 Diuretics plus human albumin;Diuretics (standard medical treatment)
45 Cost- Effectiveness and Cost-utility of Laparoscopic Versus Open Repair of Ventral Hernia: Randomized Clinical Trial Completed NCT01778387 Phase 4
46 Efficacy of Intravenous 'L-ornithine L-aspartate' in Reversal of Overt Acute Hepatic Encephalopathy in Patients With Liver Cirrhosis: a Prospective, Randomized, Double-blind, Placebo Controlled Trial Completed NCT01722578 Phase 4 L-ornithine L-aspartate;Placebo
47 Ertapenem Pharmacokinetics in Patients in Continuous Ambulatory Peritoneal Dialysis Completed NCT00939952 Phase 4 ertapenem
48 Prospective Trial Comparing the Performance Profiles of Two Non-Cross-Linked Porcine Dermal Matrices in Abdominal Wall Reconstruction Recruiting NCT02228889 Phase 4
49 Efficacy and Safety of Local Application of Chlorhexidine Gluconate Versus Mupirocin Ointment in the Prevention of Peritoneal Dialysis-Related Infection: A Double-Blind, Stratified Randomized Controlled Trial Recruiting NCT02547103 Phase 4
50 FEcal Transplant, a Hope to Eradicate Colonization of Patient Harboring eXtreme Drug Resistant Bacteria? Recruiting NCT03029078 Phase 4 fecal microbiota transplant

Search NIH Clinical Center for Peritonitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albumin Human, USP
ALBUMIN,AGGREGATED
ALBUMIN,EGG
ALBUMIN,HUMAN INJ
ALBUMIN,MICROSPHERE HUMAN SERUM
Sources

Genetic Tests for Peritonitis

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Sources

Anatomical Context for Peritonitis

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MalaCards organs/tissues related to Peritonitis:

40
Liver, Colon, Neutrophil, Small Intestine, Kidney, Testes, Lung
Sources

Publications for Peritonitis

About this section

Articles related to Peritonitis:

(show top 50) (show all 30191)
# Title Authors PMID Year
1
Mortality and risk stratification in patients with Clostridium difficile-associated diarrhoea. 54 61
19508548 2010
2
Predictors of patient survival in continuous ambulatory peritoneal dialysis: 10-year experience in 2 major centers in Tehran. 54 61
20081304 2010
3
Peritonitis from peg tube insertion in surgical intensive care unit patients: identification of risk factors and clinical outcomes. 54 61
19430836 2009
4
Endothelial dysfunction in peritoneal dialysis patients with and without failed renal transplants. 54 61
19917360 2009
5
AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis. 61 54
19401390 2009
6
Peritoneal resorption capacity for the inflammatory mediators in acute experimental Staphylococcus aureus peritonitis. 61 54
19669960 2009
7
Primary peritonitis due to brucellosis mimicking tuberculous peritonitis. 61 54
19530047 2009
8
Albumin administration in patients with severe sepsis due to secondary peritonitis. 54 61
19467947 2009
9
[Peritonitis in the course of peritoneal dialisis caused by Haemophilus influenzae with BLNAR phenotype]. 61 54
19580200 2009
10
Effect of the combination of fibrin glue and growth hormone on intestinal anastomoses in a pig model of traumatic shock associated with peritonitis. 61 54
19132439 2009
11
[The prognostic role of interleukin-6 in peritoneal exudate of patients with diffuse peritonitis]. 54 61
20020622 2009
12
Is decline in serum albumin an ominous sign for subsequent peritonitis in peritoneal dialysis patients? 54 61
19886340 2009
13
Systemic and intraperitoneal proinflammatory cytokine profiles in patients on continuous ambulatory peritoneal dialysis. 61 54
19886317 2009
14
Fungal peritonitis in peritoneal dialysis: risk factors and prognosis. 61 54
19142806 2009
15
Clinical characteristics of lower bowel perforation with chronic renal failure. 54 61
19102359 2008
16
Concentration of adipokines in peritoneal effluent: a new marker of acute peritonitis in peritoneal dialysis patients? 54 61
18708547 2008
17
The relationship of p1 and lewis antigens with peritoneal dialysis-related Escherichia coli peritonitis. 54 61
18552251 2008
18
The outcome for pediatric patients on peritoneal dialysis. 61 54
18587728 2008
19
TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis. 61 54
18354210 2008
20
[Peritonitis related to peritoneal dialysis: evaluation of 179 attacks]. 61 54
18697424 2008
21
Relation of demographic, clinic and biochemical parameters to peritonitis in peritoneal dialysis. 54 61
18336516 2008
22
A leptin serum concentration less than 10 ng/ml is a predictive marker of outcome in patients with moderate to severe secondary peritonitis. 61 54
18525209 2008
23
Proteomic analysis of peritoneal dialysate fluid in patients with dialysis-related peritonitis. 61 54
18791950 2008
24
Fas expression on peritoneal macrophages during continuous ambulatory peritoneal dialysis peritonitis. 61 54
18350449 2008
25
Streptococcus salivarius bacteremia and spontaneous bacterial peritonitis in liver transplantation candidates. 61 54
17969206 2007
26
Reduced residual renal function is a risk of peritonitis in continuous ambulatory peritoneal dialysis patients. 54 61
17517797 2007
27
Influence of peritoneal dialysis training nurses' experience on peritonitis rates. 61 54
17699477 2007
28
Peritonitis, peritoneal inflammation and membrane permeability: a longitudinal study of dialysate and serum MCP-1 in stable patients on peritoneal dialysis. 54 61
17557268 2007
29
Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis. 54 61
17224788 2007
30
Adherence to peritoneal dialysis training schedule. 61 54
17035375 2007
31
Systemic and intraperitoneal proinflammatory cytokines profiles in patients on chronic peritoneal dialysis. 61 54
18928158 2007
32
Impact of nutritional status on peritonitis in CAPD patients. 54 61
17179509 2007
33
Comparison of incidence of peritonitis between peritoneal dialysis solution types. 61 54
17409770 2007
34
Clinical predictors of ongoing infection in secondary peritonitis: systematic review. 61 54
17102920 2006
35
Compartmentalization of interleukin-6 response in a patient with septic meningococcal peritonitis. 61 54
16988004 2006
36
Malnutrition-inflammation score is a useful tool in peritoneal dialysis patients. 61 54
17047239 2006
37
Anti-inflammatory effects of a novel peptide designed to bind with NF-kappaB p50 subunit. 61 54
17049124 2006
38
Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation. 54 61
16788688 2006
39
Survival and technical failure in a large cohort of Thai CAPD patients. 54 61
17044460 2006
40
Risk factors of first peritonitis episode in Thai CAPD patients. 61 54
17044465 2006
41
Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils. 54 61
16690053 2006
42
Peritonitis in childhood: clinical relevance of cytokines in the peritoneal exudate. 61 54
16685614 2006
43
Systemic and intraperitoneal interleukin-6 system during the first year of peritoneal dialysis. 54 61
16538876 2006
44
Timely transfer of peritoneal dialysis patients to hemodialysis improves survival rates. 54 61
16429841 2006
45
Dialysate CA125 levels in children on continuous peritoneal dialysis. 61 54
16133054 2005
46
Risk factors for peritonitis in pediatric peritoneal dialysis: a single-center study. 61 54
16082548 2005
47
The impact of topical mupirocin on peritoneal dialysis infection in Singapore General Hospital. 54 61
16046516 2005
48
[A contemporary situation in the antimicrobial treatment of the secondary peritonitis]. 54 61
16250620 2005
49
The impact of topical mupirocin on peritoneal dialysis infection rates in Singapore General Hospital. 54 61
15855200 2005
50
A risk analysis of continuous ambulatory peritoneal dialysis-related peritonitis. 54 61
16022095 2005
Sources

Variations for Peritonitis

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ClinVar genetic disease variations for Peritonitis:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TMEM67 NM_153704.6(TMEM67):c.1843T>C (p.Cys615Arg)SNV Pathogenic/Likely pathogenic 1383 rs201893408 8:94808198-94808198 8:93795970-93795970
2 TMEM67 NM_153704.6(TMEM67):c.1321C>T (p.Arg441Cys)SNV Pathogenic/Likely pathogenic 217725 rs752362727 8:94798483-94798483 8:93786255-93786255
Sources

Expression for Peritonitis

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Search GEO for disease gene expression data for Peritonitis.
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Pathways for Peritonitis

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Pathways related to Peritonitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.07 TNF TLR2 MUC16 MEFV LBP ITGB2
2
ERK Signaling 63
Show member pathways
 13.86 TNF ITGB2 ITGAM IL6 IL1B IL10
3
TGF-Beta Pathway 63
Show member pathways
 13.58 TNF ITGB2 ITGAM IL6 IL1B IL10
4
Akt Signaling 63
Show member pathways
 13.51 TNF TLR2 ITGB2 ITGAM IL6 IL1B
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.41 TNF LBP ITGB2 ITGAM IL6 IL1B
6
PAK Pathway 63
Show member pathways
 13.35 TNF IL6 IL1B IL10 CXCL8 CXCL2
7
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.16 TNF TLR2 LBP IL6 IL1B IL10
8
Human cytomegalovirus infection 36
Show member pathways
 13.02 TNF TLR2 IL6 IL1B CXCL8 CXCL2
9
Allograft rejection 1 36
Show member pathways
 12.96 TNF ITGB2 IL6 IL1B IL10 CXCL8
10
Measles 36
Show member pathways
 12.93 TNF TLR2 IL6 IL1B CXCL8 CCL2
11
Herpes simplex virus 1 infection 36
12.87 TNF TLR2 IL6 IL1B CCL2 B2M
12
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.77 TNF TLR2 IL6 IL1B CXCL8
13
NF-kappaB Signaling 4
12.68 TNF TLR2 ITGB2 IL1B IL10 CCL2
14
T cell receptor signaling pathway 36
Show member pathways
 12.66 TNF TLR2 IL6 IL1B IL10
15
Th17 cell differentiation 36
Show member pathways
 12.66 TNF TLR2 IL6 IL1B IL10
16
Immune response IL-23 signaling pathway 22
Show member pathways
 12.64 TNF IL6 IL1B IL10 CCL2
17
IL-17 Family Signaling Pathways 64
Show member pathways
 12.46 TNF TLR2 IL6 IL1B CXCL8 CXCL2
18
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.44 TNF IL6 IL10 CXCL8 CXCL2 CCL2
19
Folate Metabolism 1
Show member pathways
 12.44 TNF IL6 IL1B CRP CCL2 ALB
20
Salmonella infection (KEGG) 36
12.4 TNF TLR2 IL6 IL1B CXCL8
21
Toll Comparative Pathway 63
Show member pathways
 12.39 TNF LBP IL6 IL1B CXCL8
22
Human T-cell leukemia virus 1 infection 36
12.38 TNF ITGB2 IL6 B2M
23
Toxoplasmosis 36
Show member pathways
 12.38 TNF TLR2 ITGB2 ITGAM IL1B IL10
24
NOD-like receptor signaling pathway 36
12.35 TNF MEFV IL6 IL1B CXCL8 CXCL2
25
Transcriptional misregulation in cancer 36
12.32 ITGAM IL6 FCGR1A CXCL8
26
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.32 TNF IL6 IL1B IL10 CXCL8
27
Pathogenic Escherichia coli infection 36
12.31 TNF IL6 IL1B CXCL8
28
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.31 TNF TLR2 IL6 CXCL8
29
Bacterial infections in CF airways 22
Show member pathways
 12.3 TNF TLR2 LBP IL6 IL1B CXCL8
30
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.29 TNF IL6 IL1B IL10 CXCL8
31
Tuberculosis 36
12.28 TNF TLR2 LBP ITGB2 ITGAM IL6
32
C-type lectin receptor signaling pathway 36
Show member pathways
 12.27 TNF IL6 IL1B IL10
33
Phagosome 36
12.2 TLR2 ITGB2 ITGAM FCGR1A
34
Yersinia infection 36
12.12 TNF MEFV IL6 IL1B IL10 CXCL8
35
TNF signaling pathway 36
12.11 TNF IL6 IL1B CXCL2 CCL2
36
Spinal Cord Injury 1
12.1 TNF IL6 IL1B CXCL8 CXCL2 CCL2
37
IL27-mediated signaling events 1
Show member pathways
 12.08 TNF TLR2 IL6 IL1B IL10
38
Hematopoietic Stem Cells and Lineage-specific Markers 64
12.07 TNF ITGAM IL6 IL10
39
NF-kappa B signaling pathway 36
12.06 TNF LBP IL1B CXCL8 CXCL2
40
AGE-RAGE signaling pathway in diabetic complications 36
12.04 TNF IL6 IL1B CXCL8 CCL2
41
Hematopoietic cell lineage 36
12.03 TNF ITGAM IL6 IL1B FCGR1A
42
Staphylococcus aureus infection 36
11.98 ITGB2 ITGAM IL10 FCGR1A
43
Phagocytosis of Microbes 63
11.92 TLR2 ITGB2 ITGAM FCGR1A
44
Innate Lymphoid Cells Differentiation 64
11.89 TNF ITGAM IL1B IL10
45
Rheumatoid arthritis 36
11.89 TNF TLR2 ITGB2 IL6 IL1B CXCL8
46
Dendritic Cells Developmental Lineage Pathway 64
11.88 TNF ITGAM IL6 IL1B IL10
47
Interleukin-4 and 13 signaling 65
11.87 TNF LBP ITGB2 ITGAM IL6 IL1B
48
Pertussis 36
11.86 TNF ITGB2 ITGAM IL6 IL1B IL10
49
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.79 TNF IL6 IL1B CXCL8 CXCL2
50
Lung fibrosis 1
11.79 TNF IL6 IL1B CXCL8 CXCL2 CCL2
Sources

GO Terms for Peritonitis

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Cellular components related to Peritonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF MUC16 LBP IL6 IL1B IL10
2 external side of plasma membrane GO:0009897 9.72 TNF ITGB2 ITGAM B2M ADA
3 cell surface GO:0009986 9.7 TNF TLR2 LBP ITGB2 ITGAM B2M
4 extracellular space GO:0005615 9.47 TNF MUC16 LBP ITGAM IL6 IL1B
5 integrin alphaM-beta2 complex GO:0034688 9.26 ITGB2 ITGAM

Biological processes related to Peritonitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.18 TLR2 MEFV LBP ITGAM FCGR1A B2M
2 positive regulation of gene expression GO:0010628 10.12 TNF TLR2 IL6 IL1B CRP
3 innate immune response GO:0045087 10.12 TLR2 MEFV LBP ITGAM FCGR1A CRP
4 negative regulation of cell proliferation GO:0008285 10.11 TLR2 IL6 IL1B IL10 CXCL8
5 immune response GO:0006955 10.02 TNF TLR2 IL6 IL1B IL10 FCGR1A
6 leukocyte migration GO:0050900 10 TNF ITGB2 ITGAM IL1B
7 response to lipopolysaccharide GO:0032496 9.99 TLR2 LBP IL1B IL10
8 receptor-mediated endocytosis GO:0006898 9.99 ITGB2 ITGAM FCGR1A ALB
9 positive regulation of angiogenesis GO:0045766 9.97 ITGB2 IL1B CXCL8 AQP1
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 TNF TLR2 ITGB2 IL6 IL1B
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.92 TNF IL6 IL1B IL10
12 defense response to Gram-positive bacterium GO:0050830 9.92 TNF TLR2 LBP IL6 CRP
13 chemokine-mediated signaling pathway GO:0070098 9.89 CXCL8 CXCL2 CCL2
14 cellular response to organic cyclic compound GO:0071407 9.89 TNF IL1B CCL2
15 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL10
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 TNF TLR2 IL1B
17 humoral immune response GO:0006959 9.87 TNF IL6 CCL2
18 cellular response to lipopolysaccharide GO:0071222 9.86 TNF LBP IL6 IL1B IL10 CXCL8
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 TNF ITGB2 IL1B
20 neutrophil chemotaxis GO:0030593 9.85 ITGB2 IL1B CXCL8 CXCL2 CCL2
21 positive regulation of interleukin-6 secretion GO:2000778 9.84 TNF TLR2 IL1B
22 protein kinase B signaling GO:0043491 9.83 TNF IL1B CCL2
23 acute-phase response GO:0006953 9.82 LBP IL6 CRP
24 microglial cell activation GO:0001774 9.81 TNF TLR2 ITGB2 ITGAM
25 positive regulation of JAK-STAT cascade GO:0046427 9.8 TNF IL6 IL10
26 positive regulation of interleukin-8 production GO:0032757 9.8 TNF TLR2 LBP IL1B
27 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR2 LBP IL6 IL1B
28 leukocyte chemotaxis GO:0030595 9.79 IL10 CXCL8 CXCL2
29 positive regulation of glial cell proliferation GO:0060252 9.79 TNF IL6 IL1B
30 positive regulation of superoxide anion generation GO:0032930 9.78 ITGB2 ITGAM CRP
31 negative regulation of neurogenesis GO:0050768 9.78 TNF IL6 IL1B B2M
32 embryonic digestive tract development GO:0048566 9.77 TNF CXCL8 ADA
33 toll-like receptor 4 signaling pathway GO:0034142 9.77 LBP ITGB2 ITGAM
34 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF TLR2 LBP IL1B CCL2
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 TNF IL1B IL10
36 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.74 TNF ITGB2 IL6
37 positive regulation of chemokine production GO:0032722 9.73 TNF TLR2 LBP IL6
38 cellular response to lipoteichoic acid GO:0071223 9.72 TLR2 LBP
39 cellular response to nicotine GO:0071316 9.72 TNF B2M
40 positive regulation of neuroinflammatory response GO:0150078 9.72 TNF IL6 IL1B
41 opsonization GO:0008228 9.71 LBP CRP
42 negative regulation of lipid storage GO:0010888 9.71 TNF IL6 CRP
43 regulation of establishment of endothelial barrier GO:1903140 9.7 TNF IL1B
44 endothelial cell apoptotic process GO:0072577 9.7 TNF IL10
45 negative regulation of cytokine production involved in immune response GO:0002719 9.69 TNF IL10
46 cellular extravasation GO:0045123 9.68 TNF ITGB2
47 positive regulation of fever generation GO:0031622 9.68 TNF IL1B
48 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 TNF IL10
49 negative regulation of dopamine metabolic process GO:0045963 9.66 ITGB2 ITGAM
50 positive regulation of neutrophil degranulation GO:0043315 9.66 ITGB2 ITGAM

Molecular functions related to Peritonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TNF TMEM67 TLR2 MUC16 MEFV LBP
2 amyloid-beta binding GO:0001540 9.54 TLR2 ITGB2 ITGAM
3 chemokine activity GO:0008009 9.43 CXCL8 CXCL2 CCL2
4 lipopeptide binding GO:0071723 9.32 TLR2 LBP
5 cytokine activity GO:0005125 9.17 TNF IL6 IL1B IL10 CXCL8 CXCL2
6 complement component C3b binding GO:0001851 9.16 ITGB2 ITGAM
Sources

Sources for Peritonitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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