PVL
MCID: PRV004
MIFTS: 49

Periventricular Leukomalacia (PVL)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Periventricular Leukomalacia

MalaCards integrated aliases for Periventricular Leukomalacia:

Name: Periventricular Leukomalacia 12 76 53 54 59 29 6 15
Leukomalacia, Periventricular 44 73
Leukomalacia Periventricular 55
Pvl 53

Classifications:



External Ids:

Disease Ontology 12 DOID:13088
ICD10 33 P91.2
ICD9CM 35 779.7
MeSH 44 D007969
NCIt 50 C99013
Orphanet 59 ORPHA171676
MESH via Orphanet 45 D007969
UMLS via Orphanet 74 C0023529
UMLS 73 C0023529

Summaries for Periventricular Leukomalacia

NINDS : 54 Periventricular leukomalacia (PVL) is characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns; premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the periventricular area of the brain, which results in the death or loss of brain tissue. The periventricular area-the area around the spaces in the brain called ventricles-contains nerve fibers that carry messages from the brain to the body's muscles. Although babies with PVL generally have no outward signs or symptoms of the disorder, they are at risk for motor disorders, delayed mental development, coordination problems, and vision and hearing impairments. PVL may be accompanied by a hemorrhage or bleeding in the periventricular-intraventricular area (the area around and inside the ventricles), and can lead to cerebral palsy. The disorder is diagnosed by ultrasound of the head.

MalaCards based summary : Periventricular Leukomalacia, also known as leukomalacia, periventricular, is related to leukomalacia and brain injury. An important gene associated with Periventricular Leukomalacia is MYT1 (Myelin Transcription Factor 1), and among its related pathways/superpathways are Spinal Cord Injury and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and heart, and related phenotypes are homeostasis/metabolism and mortality/aging

NIH Rare Diseases : 53 Periventricular leukomalacia (PVL) is a brain injury disorder characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns, and premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the area around the ventricles of the brain, which results in the death of brain tissue. Although babies with PVL generally have no apparent signs or symptoms of the disorder at delivery, they are at risk for motor disorders, cerebral palsy, delayed mental development, coordination problems, and vision and hearing impairments.There is no cure for PVL. Treatment is generally supportive. Prognosis is dependent on the extent of damage to the ventricles.

Wikipedia : 76 Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis... more...

Related Diseases for Periventricular Leukomalacia

Diseases related to Periventricular Leukomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 leukomalacia 32.1 IL6 MCOLN1 RPS6KC1 TNF
2 brain injury 30.5 EPO IL6 MBP
3 listeriosis 30.4 IL6 TNF
4 proliferative verrucous leukoplakia 11.7
5 fetal indomethacin syndrome 11.3
6 cerebral palsy 10.6
7 west syndrome 10.4
8 spastic diplegia 10.4
9 epilepsy 10.4
10 ischemia 10.4
11 cerebral visual impairment 10.4
12 leukoplakia 10.4
13 hypoxia 10.3
14 encephalopathy 10.3
15 scorpion envenomation 10.2 IL6 TNF
16 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
17 critical limb ischemia 10.2 IL6 TNF
18 streptococcal toxic-shock syndrome 10.2 IL6 TNF
19 juvenile ankylosing spondylitis 10.2 IL6 TNF
20 cardiogenic shock 10.2 IL6 TNF
21 null-cell leukemia 10.2 IL6 TNF
22 retinitis pigmentosa 55 10.2 IL6 TNF
23 anca-associated vasculitis 10.2 IL6 TNF
24 glossitis 10.2 IL6 TNF
25 laryngitis 10.2 IL6 TNF
26 anterior uveitis 10.2 IL6 TNF
27 acute vascular insufficiency of intestine 10.2 IL6 TNF
28 posterior urethral valves 10.2 IL6 TNF
29 adams-oliver syndrome 1 10.2
30 exudative vitreoretinopathy 1 10.2
31 schizophrenia 10.2
32 strabismus 10.2
33 oliver syndrome 10.2
34 asthma 10.2
35 bronchopulmonary dysplasia 10.2
36 adams-oliver syndrome 10.2
37 congenital cytomegalovirus 10.2
38 cytomegalovirus infection 10.2
39 osteosclerotic myeloma 10.2 IL6 TNF
40 periapical periodontitis 10.2 IL6 TNF
41 autoimmune gastritis 10.2 IL6 TNF
42 meconium aspiration syndrome 10.2 IL6 TNF
43 burning mouth syndrome 10.2 IL6 TNF
44 central nervous system vasculitis 10.2 IL6 TNF
45 stachybotrys chartarum 10.2 IL6 TNF
46 louse-borne relapsing fever 10.2 IL6 TNF
47 endometrial disease 10.2 IL6 TNF
48 ischemic heart disease 10.2 IL6 TNF
49 autoimmune disease of eyes, ear, nose and throat 10.2 IL6 TNF
50 intermediate uveitis 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Periventricular Leukomalacia:



Diseases related to Periventricular Leukomalacia

Symptoms & Phenotypes for Periventricular Leukomalacia

MGI Mouse Phenotypes related to Periventricular Leukomalacia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 ALOX15 EPO IL6 MBP MCOLN1 MYT1
2 mortality/aging MP:0010768 9.65 ALOX15 CPVL EPO IL6 MBP MCOLN1
3 muscle MP:0005369 9.1 EPO IL6 MCOLN1 MYT1 PDHA1 TNF

Drugs & Therapeutics for Periventricular Leukomalacia

Drugs for Periventricular Leukomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 183)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 1 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3 7487-88-9 24083
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-02-2 5743
6
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 378-44-9 9782
7
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3 57-83-0 5994
8
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
9 Poractant alfa Approved Phase 4 129069-19-8
10
Labetalol Approved Phase 4 36894-69-6 3869
11
Methyldopa Approved Phase 4 555-30-6 38853
12
Nifedipine Approved Phase 4 21829-25-4 4485
13
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
14
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
15 Dopamine Agents Phase 4,Phase 3,Phase 1
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Carbidopa, levodopa drug combination Phase 4
18 Sympathomimetics Phase 4,Phase 3,Phase 1,Phase 2
19 Dihydroxyphenylalanine Phase 4
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Cardiotonic Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Central Nervous System Depressants Phase 4,Phase 3
26 Anticonvulsants Phase 4,Phase 3
27 Anesthetics Phase 4,Phase 3
28 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
29 Anti-Arrhythmia Agents Phase 4,Phase 3
30 Calcium, Dietary Phase 4,Phase 3,Not Applicable
31 calcium channel blockers Phase 4,Phase 3
32 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
33 Pulmonary Surfactants Phase 4,Phase 3,Phase 2,Phase 1
34 Anticoagulants Phase 4,Phase 3,Not Applicable
35 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Betamethasone sodium phosphate Phase 4,Phase 2,Phase 3,Not Applicable
37 Betamethasone-17,21-dipropionate Phase 4,Phase 2,Phase 3,Not Applicable
38
protease inhibitors Phase 4,Phase 3,Not Applicable
39 Betamethasone Valerate Phase 4,Phase 2,Phase 3,Not Applicable 2152-44-5
40 Antiemetics Phase 4,Phase 2,Phase 3,Not Applicable
41 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
42 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
43 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Not Applicable
45 Betamethasone benzoate Phase 4,Phase 2,Phase 3,Not Applicable
46 BB 1101 Phase 4,Phase 2,Phase 3,Not Applicable
47 Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
48 HIV Protease Inhibitors Phase 4,Phase 3,Not Applicable
49 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Not Applicable
50 glucocorticoids Phase 4,Phase 2,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 144)
# Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
3 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
4 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
5 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
6 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
7 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
8 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
9 Personalized vs Standardized PN for Preterm Infants >1250g Not yet recruiting NCT03693287 Phase 4 Numeta G13®, BAXTER Spa;Personalized-parenteral nutrition.
10 Randomized Controlled Trial of Vaginal Progesterone in Women With Threatened Preterm Labor Terminated NCT01286246 Phase 4 Vaginal progesterone;Placebo
11 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
12 Management of Hypotension In the Preterm Infant Unknown status NCT01482559 Phase 3 Dopamine hydrochloride;Dextrose 5%
13 Magnesium Sulfate to Prevent Brain Injury in Premature Infants Unknown status NCT00065949 Phase 3 magnesium sulfate
14 Hybrid Versus Norwood Management Strategies in Infants Undergoing Single Ventricle Palliation Unknown status NCT01134302 Phase 3
15 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
16 Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage Completed NCT00009620 Phase 3 Phenobarbital;Saline
17 Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia Completed NCT02059135 Phase 3
18 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
19 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
20 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
21 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
22 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
23 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3 Caffeine citrate injection
24 Pentoxifylline and Late Onset Sepsis in Preterm Infants Completed NCT02163174 Phase 3 Pentoxifylline (PTX);Placebo
25 High Versus Low Dose of Caffeine for Apnea of Prematurity Completed NCT02103777 Phase 3 Caffeine citrate
26 Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA Completed NCT00440804 Phase 3 ibuprofen l-lysine iv solution (NeoProfen (R) )
27 Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies Completed NCT00135902 Phase 3 17 alpha-Hydroxyprogesterone Caproate and Omega-3 fish oils
28 Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Completed NCT00114543 Phase 3
29 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
30 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
31 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Recruiting NCT03110341 Phase 3 Erythropoietin;Normal saline
32 Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes Recruiting NCT02469519 Phase 2, Phase 3 Betamethasone - ACTIVE
33 Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm Birth Recruiting NCT02897076 Phase 3 betamethasone 24 mg;12mg betamethasone +placebo
34 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Recruiting NCT01240057 Phase 2, Phase 3
35 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Recruiting NCT02939742 Phase 2, Phase 3 Betamethasone;Placebo
36 Low-molecular-weight Heparin in Constituted Vascular Intrauterine Growth Restriction Recruiting NCT02672566 Phase 3 Enoxaparin
37 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3 inhaled nitric oxide;oxygen
38 Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia Active, not recruiting NCT02371460 Phase 3
39 Transfusion of Prematures Trial Active, not recruiting NCT01702805 Phase 3
40 Magnesium Sulphate for Preterm Birth (MASP Study) Active, not recruiting NCT01492608 Phase 3 Magnesium sulphate
41 Cervical Pessary vs Vaginal Progesterone in Preventing Preterm Birth Among Women Presenting With Short Cervix: An Open-label Randomized Controlled Trial Not yet recruiting NCT02470676 Phase 2, Phase 3 Progesterone
42 Treatment of Intrauterine Growth Restriction With Low Molecular Heparin. Not yet recruiting NCT03324139 Phase 3 Low molecular weight heparin;Placebos
43 Human Milk Fortification in Extremely Preterm Infants Not yet recruiting NCT03797157 Phase 2, Phase 3
44 Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates Not yet recruiting NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
45 Detection of False Positives From First-trimester Preeclampsia Screening (StopPRE) at the Second-trimester of Pregnancy Not yet recruiting NCT03741179 Phase 3 ASA-withdrawn group
46 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3 Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
47 Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Terminated NCT00005777 Phase 3 Dexamethasone;Placebo
48 A Randomized Study Comparing the Efficacy and Safety of Retosiban Versus Atosiban for Women in Spontaneous Preterm Labour Terminated NCT02292771 Phase 3 Retosiban;Atosiban;Placebo matching retosiban;Placebo matching atosiban
49 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
50 Effectiveness of ACS in Extreme Preemies Withdrawn NCT02351310 Phase 3 Betamethasone

Search NIH Clinical Center for Periventricular Leukomalacia

Cochrane evidence based reviews: leukomalacia, periventricular

Genetic Tests for Periventricular Leukomalacia

Genetic tests related to Periventricular Leukomalacia:

# Genetic test Affiliating Genes
1 Periventricular Leukomalacia 29

Anatomical Context for Periventricular Leukomalacia

MalaCards organs/tissues related to Periventricular Leukomalacia:

41
Brain, Skin, Heart, Eye, Lymph Node, Spinal Cord, Prostate

Publications for Periventricular Leukomalacia

Articles related to Periventricular Leukomalacia:

(show top 50) (show all 417)
# Title Authors Year
1
The p38I+ MAPK deletion in oligodendroglia does not attenuate myelination defects in a mouse model of periventricular leukomalacia. ( 29966722 )
2018
2
Development of postural control in infancy in cerebral palsy and cystic periventricular leukomalacia. ( 29787891 )
2018
3
Improvement by Human Oligodendrocyte Progenitor Cells of Neurobehavioral Disorders in an Experimental Model of Neonatal Periventricular Leukomalacia. ( 29978719 )
2018
4
Is hiragana decoding impaired in children with periventricular leukomalacia? ( 29908673 )
2018
5
Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia. ( 29217314 )
2018
6
Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. ( 29398046 )
2018
7
Cystic periventricular leukomalacia: now you see it, now you don't? ( 29576177 )
2018
8
Identifying Risk Factors Shared by Bronchopulmonary Dysplasia, Severe Retinopathy, and Cystic Periventricular Leukomalacia in Very Preterm Infants for Targeted Intervention. ( 29621770 )
2018
9
Neuronalinjury and roles of apoptosis and autophagy in a neonatal rat model of hypoxia-ischemia-induced periventricular leukomalacia. ( 29436652 )
2018
10
Supramodal agnosia for oblique mirror orientation in patients with periventricular leukomalacia. ( 29655042 )
2018
11
Ophthalmic Manifestations in Children with Periventricular Leukomalacia. ( 29511949 )
2018
12
Prediction of Periventricular Leukomalacia in Neonates after Cardiac Surgery Using Machine Learning Algorithms. ( 30116905 )
2018
13
Pathophysiology of periventricular leukomalacia: What we learned from animal models. ( 29239318 )
2017
14
Association between perinatal hypoxic-ischemia and periventricular leukomalacia in preterm infants: A systematic review and meta-analysis. ( 28931047 )
2017
15
Upper Limb Function, Kinematic Analysis, and Dystonia Assessment in Children With Spastic Diplegic Cerebral Palsy and Periventricular Leukomalacia. ( 28776460 )
2017
16
Periventricular leukomalacia with -16 DS high myopia in a 2A1 months old infant: A rare case presentation. ( 29118507 )
2017
17
A model of Periventricular Leukomalacia (PVL) in neonate mice with histopathological and neurodevelopmental outcomes mimicking human PVL in neonates. ( 28406931 )
2017
18
Confusions in Nomenclature: "Periventricular Leukomalacia" and "White Matter Injury"-Identical, Distinct, or Overlapping? ( 28648484 )
2017
19
Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats. ( 29259700 )
2017
20
The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. ( 26733225 )
2016
21
The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy. ( 27217792 )
2016
22
Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia. ( 27109442 )
2016
23
Slow pupillary light responses in infants at high risk of cerebral palsy were associated with periventricular leukomalacia and neurological outcome. ( 27468114 )
2016
24
Quality of Life of Children with Cystic Periventricular Leukomalacia - A Prospective Analysis with the Child Health Questionnaire-Parent Form 50. ( 27242979 )
2016
25
Periventricular leukomalacia in a neonatal calf. ( 27010465 )
2016
26
Isolated Cystic Periventricular Leukomalacia Differs from Cystic Periventricular Leukomalacia with Intraventricular Hemorrhage in Prevalence, Risk Factors and Outcomes in Preterm Infants. ( 27643988 )
2016
27
Diffusion-Weighted Imaging of Periventricular Leukomalacia in Very Young Children: Assessment of Peritrigonal Stripe of Restricted Diffusion. ( 28030870 )
2016
28
Cystic Periventricular Leukomalacia: A Condition that Became Uncommon in the Premature Neonate, Diagnosed on Transcranial Ultrasound. ( 30151438 )
2016
29
The whole spectrum of cystic periventricular leukomalacia of the preterm infant: results from a large consecutive case series. ( 26099229 )
2015
30
Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection. ( 25730135 )
2015
31
Bioinformatics analyses combined microarray identify the differentially expressed microRNAs in periventricular leukomalacia. ( 26812286 )
2015
32
Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia. ( 25585037 )
2015
33
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( 25448524 )
2015
34
Impact of risk factors other than prematurity on periventricular leukomalacia. A population-based matched case control study. ( 25748489 )
2015
35
Scoring system for periventricular leukomalacia in infants with congenital heart disease. ( 25996891 )
2015
36
Two important factors affecting the transition to breastfeeding in preterm infants: corrected age and periventricular leukomalacia. ( 26265900 )
2015
37
Relationship between white matter integrity and severity of motor impairment in children with cerebral palsy caused by periventricular leukomalacia. ( 26531639 )
2015
38
Clinical study of cerebral palsy in 408 children with periventricular leukomalacia. ( 25780432 )
2015
39
Increased fetal heart rate variability in periventricular leukomalacia. ( 26338690 )
2015
40
Relation between prognosis and changes of MBP and S100B in premature infants with periventricular leukomalacia. ( 25966206 )
2015
41
Corticospinal Tract Injury Precedes Thalamic Volume Reduction in Preterm Infants with Cystic Periventricular Leukomalacia. ( 26054943 )
2015
42
The Effects of the Severity of Periventricular Leukomalacia on the Neuropsychological Outcomes of Preterm Children. ( 26385973 )
2015
43
Severe cystic periventricular leukomalacia in a premature infant with capnocytophaga sepsis. ( 25452885 )
2014
44
Retinal vessel pathologies in a rat model of periventricular leukomalacia: a new model for retinopathy of prematurity? ( 25698709 )
2014
45
Latency after preterm prelabor rupture of the membranes: increased risk for periventricular leukomalacia. ( 25136457 )
2014
46
Visual Evoked Potentials in Infants With Diffuse Periventricular Leukomalacia. ( 24615931 )
2014
47
Neurodevelopmental outcomes of children with periventricular leukomalacia. ( 23727042 )
2013
48
White matter loss in a mouse model of periventricular leukomalacia is rescued by trophic factors. ( 24961618 )
2013
49
Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. ( 23879933 )
2013
50
Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. ( 23174417 )
2013

Variations for Periventricular Leukomalacia

ClinVar genetic disease variations for Periventricular Leukomalacia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RPS6KC1 NM_001287219.2(RPS6KC1): c.2074G> A (p.Gly692Ser) single nucleotide variant Likely pathogenic rs61751035 GRCh37 Chromosome 1, 213415529: 213415529
2 RPS6KC1 NM_001287219.2(RPS6KC1): c.2074G> A (p.Gly692Ser) single nucleotide variant Likely pathogenic rs61751035 GRCh38 Chromosome 1, 213242186: 213242186
3 RPS6KC1 NC_000001.10: g.(?_213396378)_(213592823_?)del deletion Likely pathogenic GRCh37 Chromosome 1, 213396378: 213592823
4 MCOLN1 NM_020533.2(MCOLN1): c.378C> G (p.Tyr126Ter) single nucleotide variant Likely pathogenic rs1057518782 GRCh37 Chromosome 19, 7591465: 7591465
5 MCOLN1 NM_020533.2(MCOLN1): c.378C> G (p.Tyr126Ter) single nucleotide variant Likely pathogenic rs1057518782 GRCh38 Chromosome 19, 7526579: 7526579
6 MCOLN1 NM_020533.2(MCOLN1): c.777+1G> C single nucleotide variant Likely pathogenic rs1057518781 GRCh38 Chromosome 19, 7527961: 7527961
7 MCOLN1 NM_020533.2(MCOLN1): c.777+1G> C single nucleotide variant Likely pathogenic rs1057518781 GRCh37 Chromosome 19, 7592847: 7592847
8 ARID1A NM_006015.5(ARID1A): c.5090A> G (p.Asp1697Gly) single nucleotide variant Likely pathogenic rs375761808 GRCh38 Chromosome 1, 26775673: 26775673
9 ARID1A NM_006015.5(ARID1A): c.5090A> G (p.Asp1697Gly) single nucleotide variant Likely pathogenic rs375761808 GRCh37 Chromosome 1, 27102164: 27102164

Expression for Periventricular Leukomalacia

Search GEO for disease gene expression data for Periventricular Leukomalacia.

Pathways for Periventricular Leukomalacia

GO Terms for Periventricular Leukomalacia

Cellular components related to Periventricular Leukomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic cup GO:0001891 8.62 MCOLN1 TNF

Biological processes related to Periventricular Leukomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neurogenesis GO:0050768 9.4 IL6 TNF
2 positive regulation of chemokine production GO:0032722 9.37 IL6 TNF
3 positive regulation of glial cell proliferation GO:0060252 9.32 IL6 TNF
4 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.26 ALOX15 TNF
5 negative regulation of lipid storage GO:0010888 9.16 IL6 TNF
6 response to salt stress GO:0009651 8.96 EPO TNF
7 positive regulation of neuroinflammatory response GO:0150078 8.62 IL6 TNF

Sources for Periventricular Leukomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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