Aliases & Classifications for Persian Gulf Syndrome

MalaCards integrated aliases for Persian Gulf Syndrome:

Name: Persian Gulf Syndrome 12 44 15 73
Gulf War Syndrome 12 55

External Ids:

Disease Ontology 12 DOID:4491
MeSH 44 D018923
SNOMED-CT 68 95877004
UMLS 73 C0282550

Summaries for Persian Gulf Syndrome

Disease Ontology : 12 A syndrome affecting returning military veterans and civilian workers of the Gulf War.

MalaCards based summary : Persian Gulf Syndrome, also known as gulf war syndrome, is related to multiple chemical sensitivity and chronic fatigue syndrome. An important gene associated with Persian Gulf Syndrome is ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1), and among its related pathways/superpathways are Arachidonic acid metabolism and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Doxycycline and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and pituitary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Gulf War syndrome, officially known as Gulf War illnesses and chronic multisymptom illness, is a chronic... more...

Related Diseases for Persian Gulf Syndrome

Diseases related to Persian Gulf Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 multiple chemical sensitivity 30.0 CYP2D6 PON1 PON2
2 chronic fatigue syndrome 10.1
3 holoprosencephaly 3 10.1 ADCYAP1 NPS VIP
4 osteoporosis 10.0
5 foodborne botulism 10.0
6 pertussis 10.0
7 lyme disease 10.0
8 giant cell tumor 10.0
9 fibromyalgia 10.0
10 dysautonomia 10.0
11 binswanger's disease 9.9 ACHE VIP
12 migraine with or without aura 1 9.8 ADCYAP1 CYP2D6 NPS TRPA1 VIP
13 disease of mental health 9.7 CYP2D6 EP300 NPS
14 parkinson disease, late-onset 9.6 ACHE ADCYAP1 CYP2D6 SOD1
15 amyotrophic lateral sclerosis 1 9.4 EP300 PON1 PON2 PON3 SOD1 TRPM7

Graphical network of the top 20 diseases related to Persian Gulf Syndrome:



Diseases related to Persian Gulf Syndrome

Symptoms & Phenotypes for Persian Gulf Syndrome

GenomeRNAi Phenotypes related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.44 PON1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.44 PON1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.44 ADCYAP1R1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.44 ACHE
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.44 PON1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.44 ACHE
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.44 ADCYAP1R1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 ACHE ADCYAP1R1 PON1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.44 PON1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.44 PON1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.44 ADCYAP1R1

MGI Mouse Phenotypes related to Persian Gulf Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.77 ACHE ADCYAP1 ADCYAP1R1 ARHGEF1 EP300 FABP3
2 cardiovascular system MP:0005385 9.76 ARHGEF1 EP300 FABP3 PON1 PON2 PON3
3 immune system MP:0005387 9.32 ADCYAP1 ADCYAP1R1 ARHGEF1 EP300 PON2 PON3

Drugs & Therapeutics for Persian Gulf Syndrome

Drugs for Persian Gulf Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
2 Anti-Infective Agents Phase 3,Phase 1
3 Antibiotics, Antitubercular Phase 3
4 Antiparasitic Agents Phase 3
5 Antimalarials Phase 3
6 Antiprotozoal Agents Phase 3
7 Antitubercular Agents Phase 3
8 Anti-Bacterial Agents Phase 3
9
Coal tar Approved Phase 1, Phase 2 8007-45-2
10
Curcumin Approved, Experimental, Investigational Phase 1, Phase 2,Not Applicable 458-37-7 969516
11
Resveratrol Approved, Experimental, Investigational Phase 2,Not Applicable 501-36-0 445154
12 Lactoferrin Phase 2
13 Muramidase Phase 2
14 Pharmaceutical Solutions Phase 2
15 Antioxidants Phase 2,Phase 1,Not Applicable
16 Peripheral Nervous System Agents Phase 1, Phase 2,Phase 2,Not Applicable
17 Protective Agents Phase 2,Not Applicable
18 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2,Phase 2,Not Applicable
19 Analgesics, Non-Narcotic Phase 1, Phase 2,Phase 2,Not Applicable
20 Antirheumatic Agents Phase 1, Phase 2,Phase 2,Not Applicable
21 Analgesics Phase 1, Phase 2,Phase 2,Not Applicable
22 Anti-Inflammatory Agents Phase 1, Phase 2,Phase 2,Not Applicable
23 Platelet Aggregation Inhibitors Phase 2,Not Applicable
24 Antineoplastic Agents, Phytogenic Phase 2,Not Applicable
25 Neuroprotective Agents Phase 2
26
Lactulose Approved Phase 1 4618-18-2 11333
27
Rifaximin Approved, Investigational Phase 1 80621-81-4 6436173
28 Nucleic Acid Synthesis Inhibitors Phase 1
29 Gastrointestinal Agents Phase 1
30
Naltrexone Approved, Investigational, Vet_approved Not Applicable 16590-41-3 5360515
31
Phenylephrine Approved Not Applicable 59-42-7 6041
32
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
33
Ephedrine Approved Not Applicable 299-42-3 9294
34
Dobutamine Approved Not Applicable 34368-04-2 36811
35
Pseudoephedrine Approved Not Applicable 90-82-4 7028
36
Indian frankincense Approved, Experimental, Investigational Not Applicable
37
Turmeric Approved, Experimental, Investigational Not Applicable
38
Glutamic Acid Approved, Nutraceutical Not Applicable 56-86-0 33032
39
St. John's Wort Approved, Investigational, Nutraceutical Not Applicable 84082-80-4
40 Immunologic Factors Not Applicable
41 Vaccines Not Applicable
42 Complement System Proteins Not Applicable
43 Narcotic Antagonists Not Applicable
44 Narcotics Not Applicable
45 Adrenergic Agonists Not Applicable
46 Vasoconstrictor Agents Not Applicable
47 Mydriatics Not Applicable
48 Adrenergic alpha-Agonists Not Applicable
49 Sympathomimetics Not Applicable
50 Nasal Decongestants Not Applicable

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Exercise and Behavioral Therapy Trial (EBT). Completed NCT00007748 Phase 3
2 Antibiotic Treatment of Gulf War Veterans' Illnesses Completed NCT00007735 Phase 3 Doxycycline (200mg/day) or Placebo
3 rTMS for the Treatment of Chronic Pain in GW1 Veterans Terminated NCT01608321 Phase 3
4 Gulf War Illness Nasal Irrigation Study Unknown status NCT01700725 Phase 2 Nasal Irrigation - Xylitol
5 Acupuncture in the Treatment of Gulf War Illness Completed NCT01305811 Phase 1, Phase 2
6 Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI) Completed NCT00810368 Phase 2 Carnosine;Placebo
7 Clinical Benefits of a Novel Sleep-focused Mind-body Program on Gulf War Illness (GWI) Symptoms Completed NCT01543997 Phase 2
8 Glutathione vs. Curcumin Clinical Trial Recruiting NCT02848417 Phase 1, Phase 2 Curcumin;Glutathione
9 Multimodal Investigation of the Neuroprotective Effects of Resveratrol (MINER) Recruiting NCT03665740 Phase 2 Resveratrol
10 Scalp Application of Red and Near-Infrared Light, From Light-Emitting Diodes (LED) to Improve Thinking and Memory in Veterans With Gulf War Illnesses Active, not recruiting NCT01782378 Phase 2
11 Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex Unknown status NCT00956150 Phase 1 Rifaximin;Placebo
12 Influenza Vaccination in Fibromyalgia Patients Unknown status NCT01465477 Not Applicable
13 Mechanisms of Mitochondrial Defects in Gulf War Syndrome Completed NCT01264471
14 Mindfulness-Based Stress Reduction for Gulf War Syndrome Completed NCT01267045 Not Applicable
15 Effects of Low Dose Naltrexone in Fibromyalgia Completed NCT00568555 Not Applicable Low Dose Naltrexone;Placebo - sugar pill
16 Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment Completed NCT00252629 Not Applicable
17 Exercise in Gulf War Illness (GWI) Completed NCT01291758
18 Investigate Olfactory Functioning as a Possible Proxy for Neurotoxic Exposure in Cohorts of Deployed and Non-Deployed Gulf War-Era Veterans. Completed NCT00007514
19 Telemedicine Treatment for Veterans With Gulf War Illness Completed NCT00129454 Not Applicable
20 Follow-up of Psychological and Neurocognitive Gulf War Outcome: Relation to Stress Completed NCT00018707
21 Sentra AM® and Sentra PM® for Post-traumatic Stress Disorder (PTSD) and Gulf War Fibromyalgia (GWF) Completed NCT01437891
22 Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans Completed NCT02075489 Not Applicable
23 Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans Completed NCT00810225
24 Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome Completed NCT00100425 Not Applicable
25 Hyporeactivity and Gulf War Illness Completed NCT00100412 Not Applicable Graded dobutamine infusions;Graded phenylephrine injections
26 Glutamate Neuro-Excitotoxicity in GWI Recruiting NCT03342482 Not Applicable
27 Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness. Recruiting NCT03547869 Not Applicable
28 Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS Recruiting NCT03030794 Not Applicable
29 START & STOPP in GWI Active, not recruiting NCT03560830
30 Effects of Botanical Microglia Modulators in Gulf War Illness Active, not recruiting NCT02909686 Not Applicable
31 Mitochondrial Cocktail for Gulf War Illness Not yet recruiting NCT02804828 Not Applicable
32 Gulf War 1 Veteran Healthcare Satisfaction Withdrawn NCT01703767

Search NIH Clinical Center for Persian Gulf Syndrome

Cochrane evidence based reviews: persian gulf syndrome

Genetic Tests for Persian Gulf Syndrome

Anatomical Context for Persian Gulf Syndrome

MalaCards organs/tissues related to Persian Gulf Syndrome:

41
Testes, Brain, Pituitary, Cortex, Hypothalamus, Thalamus, Cingulate Cortex

Publications for Persian Gulf Syndrome

Articles related to Persian Gulf Syndrome:

(show top 50) (show all 137)
# Title Authors Year
1
Electrophysiological correlates of semantic memory retrieval in Gulf War Syndrome 2 patients. ( 28131230 )
2017
2
Of poppies and men – from trench nephritis to Gulf War syndrome. ( 26054101 )
2015
3
Gulf War Syndrome: a review of current knowledge and understanding. ( 25895403 )
2014
4
Chemicals of military deployments: revisiting Gulf War Syndrome in light of new information. ( 22974741 )
2012
5
Pituitary hypophysitis and gulf war syndrome: a case series and hypothesis. ( 21521294 )
2011
6
Impotent Warriors: Gulf War Syndrome, Vulnerability and Masculinity, by Susie Kilshaw. ( 27269915 )
2009
7
Gulf war syndrome: a reaction to psychiatry's invasion of the military? ( 18363083 )
2008
8
Gulf War syndrome: an emerging threat or a piece of history? ( 22460210 )
2008
9
"Gulf war syndrome" may be related to circadian dysrhythmia. ( 17427357 )
2007
10
Latency: an important consideration in gulf war syndrome. ( 17900697 )
2007
11
Multi-symptom illnesses, unexplained illness and Gulf War Syndrome. ( 16687260 )
2006
12
Defence ministry denies ignoring Gulf war syndrome in pension award. ( 16793804 )
2006
13
Depleted uranium: all the questions about DU and Gulf War syndrome are not yet answered. ( 16981628 )
2006
14
Gulf War Syndrome: the final chapter? ( 17120396 )
2006
15
Is Gulf War Syndrome actually chronic Lyme disease? ( 15694687 )
2005
16
Gulf war syndrome: a toxic exposure? A systematic review. ( 15757795 )
2005
17
Gulf War Syndrome-the story so far. ( 15986835 )
2005
18
Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure. ( 14503920 )
2004
19
Gulf war syndrome case collapses. ( 14962868 )
2004
20
Is Gulf War Syndrome an autoimmune disorder of endogenous neuropeptides, exogenous sandfly maxadilan and molecular mimicry? ( 15082085 )
2004
21
Is osteoporosis linked to vaccinations and Gulf War Syndrome? ( 15082087 )
2004
22
Hippocampal dysfunction in Gulf War Syndrome. A proton MR spectroscopy study. ( 15120596 )
2004
23
Blunted circadian variation in autonomic regulation of sinus node function in veterans with Gulf War syndrome. ( 15464703 )
2004
24
Gulf war syndrome and sand fly saliva. ( 15488671 )
2004
25
US and UK scientists disagree about causes of Gulf war syndrome. ( 15499109 )
2004
26
Is Gulf War Syndrome really a mystery? ( 15508886 )
2004
27
US army survey targets Gulf War syndrome. ( 12556853 )
2003
28
War in Iraq. Bracing for Gulf War syndrome II. ( 12663891 )
2003
29
Gulf War syndrome revisited. ( 12776171 )
2003
30
Court stands by decision on Gulf war syndrome. ( 12816811 )
2003
31
Gulf war syndrome: narrowing the possibilities. ( 12849177 )
2003
32
Searching for a Gulf War syndrome using cluster analysis. ( 12455935 )
2002
33
Severely reduced functional status in veterans fitting a case definition of Gulf War syndrome. ( 11772758 )
2002
34
New investigations into Gulf War syndrome. ( 11875470 )
2002
35
Gulf war syndrome may be post-conflict dysfunction. ( 11950749 )
2002
36
Gulf war syndrome: could it be triggered by biological warfare-vaccines using pertussis as an adjuvant? ( 12027522 )
2002
37
Evidence for a deployment-related Gulf War syndrome by factor analysis. ( 12071362 )
2002
38
Gulf War syndrome research poised for cash injection. ( 12097870 )
2002
39
Gulf War syndrome. ( 12208628 )
2002
40
Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome. ( 12270692 )
2002
41
Effects of sarin on temperature and activity of rats as a model for gulf war syndrome neuroregulatory functions. ( 12408951 )
2002
42
Cognitive performance and cerebrohemodynamics associated with the Persian Gulf Syndrome. ( 12479508 )
2001
43
Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration. ( 12446953 )
2001
44
Vestibular toxicity is unproven as the cause of Gulf War syndrome. ( 11226967 )
2001
45
From Gulf War Syndrome to Balkan War Syndrome. ( 11259748 )
2001
46
Ten years on: what do we know about the Gulf War syndrome? King's College Gulf War Research Unit. ( 11358073 )
2001
47
The problem of Gulf War syndrome. ( 11399121 )
2001
48
Use of structural equation modeling to test the construct validity of a case definition of Gulf War syndrome: invariance over developmental and validation samples, service branches and publicity. ( 11408056 )
2001
49
Chronic perineal pain and lower urinary tract dysfunction--a clinical feature of the "Gulf War syndrome"? ( 11469610 )
2001
50
Prevalence of Gulf war veterans who believe they have Gulf war syndrome: questionnaire study. ( 11532836 )
2001

Variations for Persian Gulf Syndrome

Expression for Persian Gulf Syndrome

Search GEO for disease gene expression data for Persian Gulf Syndrome.

GO Terms for Persian Gulf Syndrome

Cellular components related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.46 ADCYAP1 ADCYAP1R1 SOD1 VIP
2 intracellular membrane-bounded organelle GO:0043231 9.35 ADCYAP1R1 CYP2D6 PON1 PON2 PON3
3 extracellular region GO:0005576 9.23 ACHE ADCYAP1 NPS PON1 PON2 PON3

Biological processes related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.67 ADCYAP1R1 FABP3 SOD1 TRPA1
2 response to ethanol GO:0045471 9.58 ADCYAP1 ADCYAP1R1 SOD1
3 cAMP-mediated signaling GO:0019933 9.51 ADCYAP1 ADCYAP1R1
4 response to toxic substance GO:0009636 9.5 PON1 PON2 PON3
5 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.49 ADCYAP1 NPS
6 positive regulation of blood vessel diameter GO:0097755 9.48 ADCYAP1 VIP
7 positive regulation of cAMP-mediated signaling GO:0043950 9.46 ADCYAP1 ADCYAP1R1
8 response to fatty acid GO:0070542 9.43 FABP3 PON1
9 negative regulation of potassium ion transport GO:0043267 9.26 ADCYAP1 VIP
10 carboxylic acid catabolic process GO:0046395 9.16 PON1 PON3
11 lipoxygenase pathway GO:0019372 9.13 PON1 PON2 PON3
12 aromatic compound catabolic process GO:0019439 8.8 PON1 PON2 PON3

Molecular functions related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.32 ADCYAP1 VIP
2 peptide hormone receptor binding GO:0051428 9.26 ADCYAP1 VIP
3 aryldialkylphosphatase activity GO:0004063 9.16 PON1 PON3
4 arylesterase activity GO:0004064 9.13 PON1 PON2 PON3
5 acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 8.8 PON1 PON2 PON3

Sources for Persian Gulf Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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