Aliases & Classifications for Persian Gulf Syndrome

MalaCards integrated aliases for Persian Gulf Syndrome:

Name: Persian Gulf Syndrome 12 45 15 17 74
Gulf War Syndrome 12 56

External Ids:

Disease Ontology 12 DOID:4491
MeSH 45 D018923
SNOMED-CT 69 95877004
UMLS 74 C0282550

Summaries for Persian Gulf Syndrome

Disease Ontology : 12 A syndrome affecting returning military veterans and civilian workers of the Gulf War.

MalaCards based summary : Persian Gulf Syndrome, also known as gulf war syndrome, is related to multiple chemical sensitivity and chronic fatigue syndrome. An important gene associated with Persian Gulf Syndrome is ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1), and among its related pathways/superpathways are Arachidonic acid metabolism and G alpha (s) signalling events. The drugs Doxycycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and testes.

Wikipedia : 77 Gulf War syndrome, officially known as Gulf War illnesses and chronic multisymptom illness, is a chronic... more...

Related Diseases for Persian Gulf Syndrome

Diseases related to Persian Gulf Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 multiple chemical sensitivity 29.7 PON1 PON2
2 chronic fatigue syndrome 10.1
3 osteoporosis 10.0
4 foodborne botulism 10.0
5 pertussis 10.0
6 lyme disease 10.0
7 giant cell tumor 10.0
8 fibromyalgia 10.0
9 dysautonomia 10.0
10 coronary heart disease 1 9.8 PON1 PON2
11 hypercholesterolemia, familial 9.7 PON1 PON2
12 holoprosencephaly 3 9.4 ADCYAP1 NPS VIP
13 migraine with or without aura 1 9.4 ADCYAP1 NPS VIP

Graphical network of the top 20 diseases related to Persian Gulf Syndrome:



Diseases related to Persian Gulf Syndrome

Symptoms & Phenotypes for Persian Gulf Syndrome

Drugs & Therapeutics for Persian Gulf Syndrome

Drugs for Persian Gulf Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
2 Anti-Bacterial Agents Phase 3,Phase 1
3 Anti-Infective Agents Phase 3,Phase 1
4 Antimalarials Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Antiprotozoal Agents Phase 3
7 Antitubercular Agents Phase 3
8 Antiparasitic Agents Phase 3
9
Curcumin Approved, Experimental, Investigational Phase 1, Phase 2,Not Applicable 458-37-7 969516
10
Coal tar Approved Phase 1, Phase 2 8007-45-2
11
Resveratrol Approved, Experimental, Investigational Phase 2,Not Applicable 501-36-0 445154
12 Antioxidants Phase 2,Phase 1,Not Applicable
13 Muramidase Phase 2
14 Lactoferrin Phase 2
15 Pharmaceutical Solutions Phase 2
16 Peripheral Nervous System Agents Phase 1, Phase 2,Phase 2,Not Applicable
17 Protective Agents Phase 2,Not Applicable
18 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2,Phase 2,Not Applicable
19 Analgesics, Non-Narcotic Phase 1, Phase 2,Phase 2,Not Applicable
20 Anti-Inflammatory Agents Phase 1, Phase 2,Phase 2,Not Applicable
21 Antirheumatic Agents Phase 1, Phase 2,Phase 2,Not Applicable
22 Analgesics Phase 1, Phase 2,Phase 2,Not Applicable
23 Platelet Aggregation Inhibitors Phase 2,Not Applicable
24 Neuroprotective Agents Phase 2
25 Antineoplastic Agents, Phytogenic Phase 2,Not Applicable
26
Rifaximin Approved, Investigational Phase 1 80621-81-4 46783403 6436173
27
Lactulose Approved Phase 1 4618-18-2 11333
28 Gastrointestinal Agents Phase 1
29
Naltrexone Approved, Investigational, Vet_approved Not Applicable 16590-41-3 5360515
30
Ethanol Approved Not Applicable 64-17-5 702
31
Phenylephrine Approved Not Applicable 59-42-7 6041
32
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
33
Pseudoephedrine Approved Not Applicable 90-82-4 7028
34
Ephedrine Approved Not Applicable 299-42-3 9294
35
Dobutamine Approved Not Applicable 34368-04-2 36811
36
Indian frankincense Approved, Experimental, Investigational Not Applicable
37
Turmeric Approved, Experimental, Investigational Not Applicable
38
Glutamic Acid Approved, Nutraceutical Not Applicable 56-86-0 33032
39
St. John's Wort Approved, Investigational, Nutraceutical Not Applicable 84082-80-4
40
Fisetin Experimental Not Applicable 528-48-3
41 Immunologic Factors Not Applicable
42 Vaccines Not Applicable
43 Complement System Proteins Not Applicable
44 Narcotic Antagonists Not Applicable
45 Narcotics Not Applicable
46 Vasoconstrictor Agents Not Applicable
47 Sympathomimetics Not Applicable
48 Adrenergic Agents Not Applicable
49 Cardiotonic Agents Not Applicable
50 Adrenergic alpha-Agonists Not Applicable

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Exercise and Behavioral Therapy Trial (EBT). Completed NCT00007748 Phase 3
2 Antibiotic Treatment of Gulf War Veterans' Illnesses Completed NCT00007735 Phase 3 Doxycycline (200mg/day) or Placebo
3 rTMS for the Treatment of Chronic Pain in GW1 Veterans Terminated NCT01608321 Phase 3
4 Acupuncture in the Treatment of Gulf War Illness Completed NCT01305811 Phase 1, Phase 2
5 Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI) Completed NCT00810368 Phase 2 Carnosine;Placebo
6 Clinical Benefits of a Novel Sleep-focused Mind-body Program on Gulf War Illness (GWI) Symptoms Completed NCT01543997 Phase 2
7 Gulf War Illness Nasal Irrigation Study Completed NCT01700725 Phase 2 Nasal Irrigation - Xylitol
8 Glutathione vs. Curcumin Clinical Trial Recruiting NCT02848417 Phase 1, Phase 2 Curcumin;Glutathione
9 Multimodal Investigation of the Neuroprotective Effects of Resveratrol (MINER) Recruiting NCT03665740 Phase 2 Resveratrol
10 Scalp Application of Red and Near-Infrared Light, From Light-Emitting Diodes (LED) to Improve Thinking and Memory in Veterans With Gulf War Illnesses Active, not recruiting NCT01782378 Phase 2
11 Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex Unknown status NCT00956150 Phase 1 Rifaximin;Placebo
12 Influenza Vaccination in Fibromyalgia Patients Unknown status NCT01465477 Not Applicable
13 Mechanisms of Mitochondrial Defects in Gulf War Syndrome Completed NCT01264471
14 Mindfulness-Based Stress Reduction for Gulf War Syndrome Completed NCT01267045 Not Applicable
15 Effects of Low Dose Naltrexone in Fibromyalgia Completed NCT00568555 Not Applicable Low Dose Naltrexone;Placebo - sugar pill
16 Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment Completed NCT00252629 Not Applicable
17 Exercise in Gulf War Illness (GWI) Completed NCT01291758
18 Investigate Olfactory Functioning as a Possible Proxy for Neurotoxic Exposure in Cohorts of Deployed and Non-Deployed Gulf War-Era Veterans. Completed NCT00007514
19 Telemedicine Treatment for Veterans With Gulf War Illness Completed NCT00129454 Not Applicable
20 Follow-up of Psychological and Neurocognitive Gulf War Outcome: Relation to Stress Completed NCT00018707
21 Sentra AM® and Sentra PM® for Post-traumatic Stress Disorder (PTSD) and Gulf War Fibromyalgia (GWF) Completed NCT01437891
22 Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans Completed NCT02075489 Not Applicable
23 Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans Completed NCT00810225
24 Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome Completed NCT00100425 Not Applicable
25 Hyporeactivity and Gulf War Illness Completed NCT00100412 Not Applicable Graded dobutamine infusions;Graded phenylephrine injections
26 Glutamate Neuro-Excitotoxicity in GWI Recruiting NCT03342482 Not Applicable
27 Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness. Recruiting NCT03547869 Not Applicable
28 Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS Recruiting NCT03030794 Not Applicable
29 START & STOPP in GWI Active, not recruiting NCT03560830
30 Effects of Botanical Microglia Modulators in Gulf War Illness Active, not recruiting NCT02909686 Not Applicable
31 Mitochondrial Cocktail for Gulf War Illness Not yet recruiting NCT02804828 Not Applicable
32 Gulf War 1 Veteran Healthcare Satisfaction Withdrawn NCT01703767

Search NIH Clinical Center for Persian Gulf Syndrome

Cochrane evidence based reviews: persian gulf syndrome

Genetic Tests for Persian Gulf Syndrome

Anatomical Context for Persian Gulf Syndrome

MalaCards organs/tissues related to Persian Gulf Syndrome:

42
Cortex, Brain, Testes, Thalamus, Cingulate Cortex, Pituitary, Hypothalamus

Publications for Persian Gulf Syndrome

Articles related to Persian Gulf Syndrome:

(show top 50) (show all 145)
# Title Authors Year
1
Electrophysiological correlates of semantic memory retrieval in Gulf War Syndrome 2 patients. ( 28131230 )
2017
2
Of poppies and men – from trench nephritis to Gulf War syndrome. ( 26054101 )
2015
3
Gulf War Syndrome: a review of current knowledge and understanding. ( 25895403 )
2014
4
Objective evidence of autonomic dysfunction and the role of stress in the Gulf War syndrome. ( 23407742 )
2013
5
Gulf War syndrome as a part of the autoimmune (autoinflammatory) syndrome induced by adjuvant (ASIA). ( 22235052 )
2012
6
Chemicals of military deployments: revisiting Gulf War Syndrome in light of new information. ( 22974741 )
2012
7
Pituitary hypophysitis and gulf war syndrome: a case series and hypothesis. ( 21521294 )
2011
8
Impotent Warriors: Gulf War Syndrome, Vulnerability and Masculinity, by Susie Kilshaw. ( 27269915 )
2009
9
Gulf war syndrome: a reaction to psychiatry's invasion of the military? ( 18363083 )
2008
10
Gulf War syndrome: an emerging threat or a piece of history? ( 22460210 )
2008
11
"Gulf war syndrome" may be related to circadian dysrhythmia. ( 17427357 )
2007
12
Latency: an important consideration in gulf war syndrome. ( 17900697 )
2007
13
Multi-symptom illnesses, unexplained illness and Gulf War Syndrome. ( 16687260 )
2006
14
Defence ministry denies ignoring Gulf war syndrome in pension award. ( 16793804 )
2006
15
Depleted uranium: all the questions about DU and Gulf War syndrome are not yet answered. ( 16981628 )
2006
16
Gulf War Syndrome: the final chapter? ( 17120396 )
2006
17
Dysautonomia in Gulf War syndrome and in fibromyalgia. ( 15808150 )
2005
18
Is Gulf War Syndrome actually chronic Lyme disease? ( 15694687 )
2005
19
Gulf war syndrome: a toxic exposure? A systematic review. ( 15757795 )
2005
20
Gulf War Syndrome-the story so far. ( 15986835 )
2005
21
Do vasoactive neuropeptide autoimmune disorders explain pyridostigmine's association with Gulf War syndrome? ( 16004938 )
2005
22
Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure. ( 14503920 )
2004
23
Gulf war syndrome case collapses. ( 14962868 )
2004
24
Is Gulf War Syndrome an autoimmune disorder of endogenous neuropeptides, exogenous sandfly maxadilan and molecular mimicry? ( 15082085 )
2004
25
Is osteoporosis linked to vaccinations and Gulf War Syndrome? ( 15082087 )
2004
26
Hippocampal dysfunction in Gulf War Syndrome. A proton MR spectroscopy study. ( 15120596 )
2004
27
Blunted circadian variation in autonomic regulation of sinus node function in veterans with Gulf War syndrome. ( 15464703 )
2004
28
Cardiac autonomic dysfunction in Gulf War syndrome: veterans' hearts don't rest at night. ( 15464714 )
2004
29
Gulf war syndrome and sand fly saliva. ( 15488671 )
2004
30
US and UK scientists disagree about causes of Gulf war syndrome. ( 15499109 )
2004
31
Is Gulf War Syndrome really a mystery? ( 15508886 )
2004
32
US army survey targets Gulf War syndrome. ( 12556853 )
2003
33
War in Iraq. Bracing for Gulf War syndrome II. ( 12663891 )
2003
34
Gulf War syndrome revisited. ( 12776171 )
2003
35
Court stands by decision on Gulf war syndrome. ( 12816811 )
2003
36
Gulf war syndrome: narrowing the possibilities. ( 12849177 )
2003
37
Severely reduced functional status in veterans fitting a case definition of Gulf War syndrome. ( 11772758 )
2002
38
New investigations into Gulf War syndrome. ( 11875470 )
2002
39
Gulf war syndrome may be post-conflict dysfunction. ( 11950749 )
2002
40
Gulf war syndrome: could it be triggered by biological warfare-vaccines using pertussis as an adjuvant? ( 12027522 )
2002
41
Evidence for a deployment-related Gulf War syndrome by factor analysis. ( 12071362 )
2002
42
Gulf War syndrome research poised for cash injection. ( 12097870 )
2002
43
Gulf War syndrome. ( 12208628 )
2002
44
Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome. ( 12270692 )
2002
45
Effects of sarin on temperature and activity of rats as a model for gulf war syndrome neuroregulatory functions. ( 12408951 )
2002
46
Searching for a Gulf War syndrome using cluster analysis. ( 12455935 )
2002
47
Cognitive performance and cerebrohemodynamics associated with the Persian Gulf Syndrome. ( 12479508 )
2001
48
Vestibular toxicity is unproven as the cause of Gulf War syndrome. ( 11226967 )
2001
49
From Gulf War Syndrome to Balkan War Syndrome. ( 11259748 )
2001
50
Ten years on: what do we know about the Gulf War syndrome? King's College Gulf War Research Unit. ( 11358073 )
2001

Variations for Persian Gulf Syndrome

Expression for Persian Gulf Syndrome

Search GEO for disease gene expression data for Persian Gulf Syndrome.

Pathways for Persian Gulf Syndrome

GO Terms for Persian Gulf Syndrome

Cellular components related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 ADCYAP1 NPS PON1 PON2 VIP
2 perikaryon GO:0043204 8.96 ADCYAP1 VIP

Biological processes related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.65 ADCYAP1 NPS VIP
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.46 ADCYAP1 VIP
3 neuropeptide signaling pathway GO:0007218 9.43 ADCYAP1 NPS
4 response to toxic substance GO:0009636 9.4 PON1 PON2
5 regulation of protein localization GO:0032880 9.37 ADCYAP1 VIP
6 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.32 ADCYAP1 NPS
7 positive regulation of blood vessel diameter GO:0097755 9.26 ADCYAP1 VIP
8 lipoxygenase pathway GO:0019372 9.16 PON1 PON2
9 negative regulation of potassium ion transport GO:0043267 8.96 ADCYAP1 VIP
10 aromatic compound catabolic process GO:0019439 8.62 PON1 PON2

Molecular functions related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.32 ADCYAP1 VIP
2 neuropeptide hormone activity GO:0005184 9.26 ADCYAP1 VIP
3 peptide hormone receptor binding GO:0051428 9.16 ADCYAP1 VIP
4 arylesterase activity GO:0004064 8.96 PON1 PON2
5 acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 8.62 PON1 PON2

Sources for Persian Gulf Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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