PGL
MCID: PRS123
MIFTS: 37

Persistent Generalized Lymphadenopathy (PGL)

Categories: Immune diseases

Aliases & Classifications for Persistent Generalized Lymphadenopathy

MalaCards integrated aliases for Persistent Generalized Lymphadenopathy:

Name: Persistent Generalized Lymphadenopathy 12 15
Persistant Generalized Lymphadenopathy 70
Pgl 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060314
UMLS 70 C0856916

Summaries for Persistent Generalized Lymphadenopathy

Disease Ontology : 12 A lymph node disease characterized by enlarged, non-painful lymph nodes occurring for more than three to six months for which no other reason can be found.

MalaCards based summary : Persistent Generalized Lymphadenopathy, also known as persistant generalized lymphadenopathy, is related to paragangliomas 1 and hereditary paraganglioma-pheochromocytoma syndromes. An important gene associated with Persistent Generalized Lymphadenopathy is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Pathways in cancer and Glucose / Energy Metabolism. The drugs Zidovudine and Aldesleukin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, thyroid and skin, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 73 Persistent generalized lymphadenopathy (PGL) is enlarged, painless, non-tender lymph nodes occurring in... more...

Related Diseases for Persistent Generalized Lymphadenopathy

Diseases related to Persistent Generalized Lymphadenopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 32.5 SDHD SDHC SDHB SDHA
2 hereditary paraganglioma-pheochromocytoma syndromes 30.6 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
3 pheochromocytoma-paraganglioma 29.8 TMEM127 SDHD SDHC SDHB SDHA RET
4 cowden syndrome 1 29.7 SDHD SDHB NF1
5 gastrointestinal stromal tumor 29.5 SDHD SDHC SDHB SDHA NF1 EPAS1
6 cowden syndrome 29.4 SDHD SDHC SDHB RET NF1 MIR21
7 peripheral nervous system disease 29.3 SERPINA3 SDHD NF1 MIR21 KIF1B
8 renal cell carcinoma, nonpapillary 28.9 SDHC SDHB RET MIR21 FH EPAS1
9 paraganglioma and gastric stromal sarcoma 28.4 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
10 paraganglioma 28.2 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
11 pheochromocytoma 28.1 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
12 leprosy 3 10.7
13 hansen's disease 10.7
14 acquired immunodeficiency syndrome 10.5
15 hemorrhagic fever-renal syndrome 10.4 CD79A CD40LG
16 c1q nephropathy 10.4 CD79A CD40LG
17 cryofibrinogenemia 10.4 CD79A CD40LG
18 immunoglobulin g deficiency 10.4 CD79A CD40LG
19 ocular toxoplasmosis 10.4 CD79A CD40LG
20 respiratory papillomatosis, juvenile recurrent, congenital 10.4 CD79A CD40LG
21 congenital syphilis 10.4 CD79A CD40LG
22 secondary syphilis 10.4 CD79A CD40LG
23 b-lymphoblastic leukemia/lymphoma with hypodiploidy 10.3 SDHA RET
24 skin lipoma 10.3 RET NF1
25 sclerosing hepatic carcinoma 10.3 CHGA CD79A
26 horner's syndrome 10.3 SDHD NF1
27 neurofibromatosis, type ii 10.3 SDHD SDHB NF1
28 autosomal dominant secondary polycythemia 10.3 EPAS1 EGLN1
29 erythrocytosis, familial, 4 10.3 EPAS1 EGLN1
30 adrenal gland pheochromocytoma 10.2
31 lepromatous leprosy 10.2
32 acquired polycythemia 10.2 EPAS1 EGLN1
33 carcinoid syndrome 10.2 SDHD CHGA
34 leiomyoma cutis 10.2 SDHD FH
35 cerebellar angioblastoma 10.2 SDHD SDHC SDHB SDHA
36 kaposi sarcoma 10.2
37 human immunodeficiency virus type 1 10.2
38 tetanus 10.2
39 purpura 10.2
40 lymphopenia 10.2
41 solid adenocarcinoma with mucin production 10.2 RET CHGA
42 carney triad 10.2 SDHD SDHC SDHB SDHA
43 nonsyndromic paraganglioma 10.2 SDHB RET CHGA
44 foster-kennedy syndrome 10.2 SDHD SDHC SDHAF2 SDHA
45 subglottis benign neoplasm 10.2 SDHC SDHB NF1 CD79A
46 duodenal somatostatinoma 10.2 NF1 EPAS1 EGLN1
47 spastic paraplegia 38, autosomal dominant 10.2 SDHB SDHA
48 gastrointestinal lymphoma 10.2 SERPINA3 CD79A
49 familial renal papillary carcinoma 10.2 SDHB FH
50 neurofibromatosis 10.2 SDHD SDHB RET NF1

Graphical network of the top 20 diseases related to Persistent Generalized Lymphadenopathy:



Diseases related to Persistent Generalized Lymphadenopathy

Symptoms & Phenotypes for Persistent Generalized Lymphadenopathy

MGI Mouse Phenotypes related to Persistent Generalized Lymphadenopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 CD40LG CD79A CHGA EGLN1 EPAS1 FH
2 hematopoietic system MP:0005397 10.06 CD40LG CD79A EGLN1 EPAS1 KIF1B NF1
3 mortality/aging MP:0010768 10.06 CD40LG CD79A CHGA EGLN1 EPAS1 FH
4 embryo MP:0005380 10.02 EGLN1 EPAS1 KIF1B MAX MDH2 NF1
5 nervous system MP:0003631 9.7 CD40LG CD79A CHGA EGLN1 EPAS1 KIF1B
6 renal/urinary system MP:0005367 9.23 CD40LG CD79A CHGA EGLN1 FH NF1

Drugs & Therapeutics for Persistent Generalized Lymphadenopathy

Drugs for Persistent Generalized Lymphadenopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zidovudine Approved Phase 1 30516-87-1 35370
2
Aldesleukin Approved Phase 1 110942-02-4, 85898-30-2
3 Antimetabolites Phase 1
4 Reverse Transcriptase Inhibitors Phase 1
5 Anti-Infective Agents Phase 1
6 Anti-HIV Agents Phase 1
7 Anti-Retroviral Agents Phase 1
8 Antiviral Agents Phase 1
9 Interleukin-2 Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open Label, Multiple Dose Ranging Trial of AL721 in Patients With Persistent Generalized Lymphadenopathy and Symptomatic HIV Infection Completed NCT00001012 Phase 1 AL 721
2 Phase I Trial of the Combination of Zidovudine and Recombinant Interleukin-2 in Patients With Persistent Generalized Lymphadenopathy Completed NCT00000728 Phase 1 Zidovudine;Aldesleukin
3 The Efficacy and Safety of Retrovir in Patients Infected With HIV Who Are Asymptomatic (CDC Group II) or Have Persistent Generalized Lymphadenopathy (CDC Group III) Completed NCT00002048 Zidovudine

Search NIH Clinical Center for Persistent Generalized Lymphadenopathy

Genetic Tests for Persistent Generalized Lymphadenopathy

Anatomical Context for Persistent Generalized Lymphadenopathy

MalaCards organs/tissues related to Persistent Generalized Lymphadenopathy:

40
Lymph Node, Thyroid, Skin, Monocytes, Eye, Salivary Gland, T Cells

Publications for Persistent Generalized Lymphadenopathy

Articles related to Persistent Generalized Lymphadenopathy:

(show top 50) (show all 287)
# Title Authors PMID Year
1
Clinical Course of Opportunistic Infections-Toxoplasmosis and Cytomegalovirus Infection in HIV-Infected Patients in Slovakia. 61
31690039 2019
2
Lymphadenopathies in human immunodeficiency virus infection. 61
29277280 2018
3
Etiological study of lymphadenopathy in HIV-infected patients in a tertiary care hospital. 61
27279680 2016
4
Immune restoration Klebsiella lymphadenitis. 61
21890558 2011
5
PET/CT in the evaluation of lymphoma in patients with HIV-1 with suppressed viral loads. 61
18716509 2008
6
Diagnostic yield of fine-needle aspiration cytology in HIV-infected patients with lymphadenopathy in the era of highly active antiretroviral therapy. 61
18663044 2008
7
Ophthalmic manifestations of HIV infections in India in the era of HAART: analysis of 100 consecutive patients evaluated at a tertiary eye care center in India. 61
18780260 2008
8
The benign lymphoepithelial cyst and a classification system for lymphocytic parotid gland enlargement in the pediatric HIV population. 61
17202938 2007
9
Soft tissue rheumatic lesions and HIV infection in Zambians. 61
17143983 2006
10
Persistent generalized lymphadenopathy (PGL) mimicking lymphoma on whole-body FDG PET/CT imaging. 61
16785807 2006
11
Human immunodeficiency virus-associated disorders in Pakistan. 61
16689473 2006
12
Clinical profile of pediatric HIV infection from India. 61
15777991 2005
13
Different localization of dendritic cell reservoirs in human immunodeficiency virus-1 subtype B versus subtype E-infected lymph nodes. 61
12777998 2003
14
The natural history of human immunodeficiency virus infection among adults in Mumbai. 61
12929853 2003
15
Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome. 61
12676041 2003
16
Clinical profile of HIV infection. 61
11255299 2001
17
Health care utilization and survival among patients with AIDS in Belo Horizonte, Minas Gerais, Brazil. 61
9878914 1998
18
Diagnostic utility of fine needle aspiration (FNA) cytology in HIV-infected patients with lymphadenopathy. 61
9710693 1998
19
Chest imaging in AIDS. 61
9744580 1998
20
Clinical features & HIV progression as observed longitudinally in a cohort of injecting drug users in Manipur. 61
9785679 1998
21
Correlation of the ratio of CD4+/CD8+ cells in lymph node fine needle aspiration biopsies with HIV clinical status. A preliminary study. 61
9390138 1997
22
BETA-2-MICROGLOBULIN LEVELS IN HUMAN-IMMUNODEFICIENCY VIRUS INFECTED SUBJECTS. 61
28769505 1997
23
Effects of smoking and clinical status on lung function in human immunodeficiency virus (HIV)-seropositive subjects. 61
9156145 1997
24
Activated cytotoxic lymphocytes in lymph nodes from human immunodeficiency virus (HIV) 1-infected patients: a light and electronmicroscopic study. 61
9023555 1997
25
Identification of cell subsets expressing intracytoplasmic cytokines within HIV-1-infected lymph nodes. 61
8931780 1996
26
Longitudinal studies of children born to HIV-1 antibody positive Filipino commercial sex workers (CSW): diagnostic dilemmas. 61
8799785 1996
27
Lymphoid infiltrates of the salivary glands: pathology, biology and clinical significance. 61
8804813 1996
28
Human herpesvirus-8 DNA sequences in human immunodeficiency virus-negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy with giant germinal center hyperplasia and increased vascularity. 61
8611719 1996
29
Initial studies on active immunization of HIV-infected subjects using a gp120-depleted HIV-1 Immunogen: long-term follow-up. 61
8601221 1996
30
Arthritis associated with HIV infection in Zimbabwe. 61
8832993 1996
31
Distinct alterations in the distribution of CD45RO+ T-cell subsets in HIV-2 compared with HIV-1 infection. 61
7888114 1994
32
Molecular pathology of AIDS-related lymphomas. Biologic aspects and clinicopathologic heterogeneity. 61
7993935 1994
33
Analysis of lymphocyte cell death and apoptosis in HIV-2-infected patients. 61
7955520 1994
34
Changes of blood CD16/CD56 (NK) and HLA-DR/CD3-positive lymphocyte amounts in HIV-infected children, as related to clinical progression and p24-antigen/p24-antibody presence. 61
7529081 1994
35
Follicular dendritic cells retain HIV-1 particles on their plasma membrane, but are not productively infected in asymptomatic patients with follicular hyperplasia. 61
8027562 1994
36
Comparison of viral burden and phenotype of HIV-1 isolates from lymph nodes and blood. 61
7986403 1994
37
Dendritic cells persistently stimulate antibody responses to HIV in seropositive individuals. 61
7986405 1994
38
Disturbed immunoregulatory properties of the neuropeptide substance P on lymphocyte proliferation in HIV infection. 61
7516268 1994
39
Analysis of Epstein-Barr virus-encoded small RNA 1 expression in benign lymphoepithelial salivary gland lesions. 61
7937721 1994
40
Histopathology and viral antigen distribution in lymph nodes of cats naturally infected with feline immunodeficiency virus. 61
7948383 1994
41
The in vivo expression of cytokine genes in humans. 61
8032714 1994
42
Demonstration of isolated follicular dendritic cells in lymphatic vessels around human immunodeficiency virus-infected lymph nodes. 61
7515756 1994
43
Persistent generalized lymphadenopathy and non-Hodgkin's lymphoma in AIDS: association with Rochalimaea henselae infection. 61
7496912 1994
44
Detection of Epstein-Barr genome in the lymph nodes of Hodgkin's disease. 61
8121864 1993
45
The use of fine needle aspiration cytology in the management of human immunodeficiency virus-related non-Hodgkin's lymphoma and Hodgkin's disease. 61
8254471 1993
46
HTLV-II/HIV-1 coinfection and risk for progression to AIDS among intravenous drug users. 61
7901382 1993
47
Benign lymphoepithelial lesions of the parotid. 61
8214302 1993
48
Increased expression of interferon-gamma in hyperplastic lymph nodes from HIV-infected patients. 61
8467556 1993
49
Patients infected with human immunodeficiency virus type 1 have low levels of virus in saliva even in the presence of periodontal disease. 61
8450244 1993
50
Electrophysiological study (VEP, BAEP) in HIV-1 seropositive patients with and without AIDS. 61
8506747 1993

Variations for Persistent Generalized Lymphadenopathy

Expression for Persistent Generalized Lymphadenopathy

Search GEO for disease gene expression data for Persistent Generalized Lymphadenopathy.

Pathways for Persistent Generalized Lymphadenopathy

GO Terms for Persistent Generalized Lymphadenopathy

Cellular components related to Persistent Generalized Lymphadenopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.76 SDHD SDHC SDHB SDHAF2 SDHA MDH2
2 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Persistent Generalized Lymphadenopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.8 SDHD SDHC SDHB SDHA MDH2 EGLN1
2 electron transport chain GO:0022900 9.58 SDHC SDHB SDHA
3 respiratory electron transport chain GO:0022904 9.43 SDHB SDHA
4 malate metabolic process GO:0006108 9.37 MDH2 FH
5 aerobic respiration GO:0009060 9.33 SDHC SDHB MDH2
6 succinate metabolic process GO:0006105 9.26 SDHB SDHA
7 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.26 SDHD SDHC SDHAF2 SDHA
8 tricarboxylic acid cycle GO:0006099 9.17 SDHD SDHC SDHB SDHAF2 SDHA MDH2

Molecular functions related to Persistent Generalized Lymphadenopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 9.26 SDHD SDHB
2 electron transfer activity GO:0009055 9.26 SDHD SDHC SDHB SDHA
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.16 SDHB SDHA
4 succinate dehydrogenase activity GO:0000104 8.8 SDHD SDHC SDHA

Sources for Persistent Generalized Lymphadenopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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