PGAD
MCID: PRS119
MIFTS: 18

Persistent Genital Arousal Disorder (PGAD)

Categories: Mental diseases, Neuronal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Persistent Genital Arousal Disorder

MalaCards integrated aliases for Persistent Genital Arousal Disorder:

Name: Persistent Genital Arousal Disorder 20
Persistent Genital Arousal 20
Pgad 20

Classifications:



Summaries for Persistent Genital Arousal Disorder

GARD : 20 Persistent genital arousal disorder (PGAD) in men may be considered as the condition of priapism and unwanted ejaculatory fluids being released without any sexual interest. In women there is still no consensus about a formal definition, but some of the experts propose that in women it should be defined as a rare, unwanted, and intrusive sexual dysfunction associated with excessive and unremitting genital arousal and engorgement in the absence of sexual interest. The persistent genital arousal usually does not resolve with orgasm and causes personal distress. Features include excessive excitement or excessive genital (lubrication, swelling, and engorgement) or other somatic responses. Causes may be neurological (central or peripheral involving the pudendal nerve), related to medication, vascular, hormonal, psychological or others. Diagnosis of the cause is essential for an adequate patient management. The treatment may include avoiding offending medications, using medications that stabilize nerve transmission and/or effect mood, local topical anesthetic agents, ice and hormonal replacement. More recently PGAD has being described as one component of a broader Restless Genital Syndrome if the PGAD was also associated with urinary frequency/urgency and restless leg syndrome.

MalaCards based summary : Persistent Genital Arousal Disorder, also known as persistent genital arousal, is related to tarlov cysts and low compliance bladder. An important gene associated with Persistent Genital Arousal Disorder is OXT (Oxytocin/Neurophysin I Prepropeptide). The drugs Epinephrine and Dopamine have been mentioned in the context of this disorder.

Wikipedia : 73 Persistent genital arousal disorder (PGAD), previously called persistent sexual arousal syndrome, is... more...

Related Diseases for Persistent Genital Arousal Disorder

Diseases related to Persistent Genital Arousal Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 tarlov cysts 10.5
2 low compliance bladder 10.4
3 restless legs syndrome 10.4
4 obsessive-compulsive disorder 10.3
5 sexual disorder 10.3
6 varicose veins 10.2
7 major affective disorder 8 10.2
8 major affective disorder 9 10.2
9 bipolar disorder 10.2
10 priapism 10.2
11 pelvic varices 10.2
12 pseudobulbar affect 10.2
13 neural tube defects 10.1
14 meningioma, familial 10.1
15 major depressive disorder 10.1
16 stuttering 10.1
17 spina bifida occulta 10.1
18 urinary tract infection 10.1
19 intracranial meningioma 10.1
20 premature ejaculation 10.1
21 polyneuropathy 10.1
22 personality disorder 10.1
23 mental depression 10.1
24 secretory meningioma 10.1
25 lymphoplasmacyte-rich meningioma 10.1
26 chronic fatigue syndrome 10.1
27 neuropathy 10.1
28 depression 10.1
29 back pain 10.1
30 paresthesia 10.1
31 low-flow priapism 10.1
32 interstitial cystitis 10.0
33 cystitis 10.0
34 peripheral nervous system disease 10.0
35 erythromelalgia 10.0
36 taylor's syndrome 10.0
37 pudendal neuralgia 10.0
38 chronic pain 10.0

Graphical network of the top 20 diseases related to Persistent Genital Arousal Disorder:



Diseases related to Persistent Genital Arousal Disorder

Symptoms & Phenotypes for Persistent Genital Arousal Disorder

Drugs & Therapeutics for Persistent Genital Arousal Disorder

Drugs for Persistent Genital Arousal Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Dopamine Approved 51-61-6, 62-31-7 681
3
Racepinephrine Approved 329-65-7 838
4 Epinephryl borate
5
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification of Etiopathological and Clinical Factors in Persistent Genital Arousal Disorder: The iPGAD-Study Recruiting NCT04566783

Search NIH Clinical Center for Persistent Genital Arousal Disorder

Genetic Tests for Persistent Genital Arousal Disorder

Anatomical Context for Persistent Genital Arousal Disorder

Publications for Persistent Genital Arousal Disorder

Articles related to Persistent Genital Arousal Disorder:

(show top 50) (show all 119)
# Title Authors PMID Year
1
International Society for the Study of Women's Sexual Health (ISSWSH) Review of Epidemiology and Pathophysiology, and a Consensus Nomenclature and Process of Care for the Management of Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD). 61
33612417 2021
2
Global incidence of spinal perineural Tarlov's cysts and their morphological characteristics: a meta-analysis of 13,266 subjects. 61
33452905 2021
3
Online Pelvic Floor Group Education Program for Women With Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia: Descriptive Feasibility Study. 61
33427673 2021
4
Persistent Genital Arousal Disorder: A Study on an Italian Group of Female University Students. 61
32762421 2021
5
Application of Botulinum Neurotoxin in Female Sexual and Genitourinary Dysfunction: A Review of Current Practices. 61
32238326 2021
6
Increased spontaneous CCL2 (MCP-1) and CCL5 (RANTES) secretion in vitro in LADA compared to type 1 diabetes and type 2 diabetes: Action LADA 14. 61
33369072 2020
7
Prevalence of Persistent Genital Arousal Disorder in 2 North American Samples. 61
33067159 2020
8
Tarlov's cyst as an underestimated cause of persistent genital arousal disorder: a case report and review. 61
32518994 2020
9
Sleep and Sex: A Review of the Interrelationship of Sleep and Sexuality Disorders in the Female Population, Through the Lens of Sleeping Beauty Syndrome. 61
33023862 2020
10
Persistent Genital Arousal Disorder: Review of Pertinent Peripheral Nerves. 61
31704111 2020
11
Persistent genital arousal disorder: Treatment by neurolysis of dorsal branch of pudendal nerve. 61
31025770 2020
12
A Comparison of Medical Comorbidities, Psychosocial, and Sexual Well-being in an Online Cross-Sectional Sample of Women Experiencing Persistent Genital Arousal Symptoms and a Control Group. 61
31680008 2020
13
Persistent Genital Arousal Disorder After Motor Vehicle Accident: A Case Report. 61
33786498 2020
14
Persistent genital arousal disorder: a special sense neuropathy. 61
32072096 2020
15
Responder Threshold for Patient-Oriented Eczema Measure (POEM) and Children's Dermatology Life Quality Index (CDLQI) in Adolescents with Atopic Dermatitis. 61
31641952 2019
16
Validation of the Atopic Dermatitis Control Tool (ADCT©) using a longitudinal survey of biologic-treated patients with atopic dermatitis. 61
31690295 2019
17
Identification of Acinetobacter baumannii and its carbapenem-resistant gene blaOXA-23-like by multiple cross displacement amplification combined with lateral flow biosensor. 61
31784652 2019
18
Global gene expression analysis of Escherichia coli K-12 DH5α after exposure to 2.4 GHz wireless fidelity radiation. 61
31595026 2019
19
Zolpidem related persistent genital arousal disorder: An interesting case. 61
32283537 2019
20
Mental health of patients with adolescent idiopathic scoliosis and their parents in China: a cross-sectional survey. 61
31088538 2019
21
Case Report: Persistent Genital Arousal Disorder in an Adolescent Woman. 61
30513343 2019
22
Visual and rapid detection of Acinetobacter baumannii by a multiple cross displacement amplification combined with nanoparticles-based biosensor assay. 61
30806854 2019
23
Refractory Sexual Arousal Subsequent to Sacral Neuromodulation. 61
31065392 2019
24
Genital Sensations in Persistent Genital Arousal Disorder: A Case for an Overarching Nosology of Genitopelvic Dysesthesias? 61
30301706 2019
25
[Persistent Genital Arousal Disorder Treated with Duloxetine: A Case Report]. 61
31170309 2019
26
Assessment of biofilm formation among clinical isolates of Acinetobacter baumannii in burn wounds in the west of Iran. 61
30672433 2018
27
Can pharmacotherapy help persistent genital arousal disorder? 61
30220233 2018
28
Histone Deacetylase 7-Derived Peptides Play a Vital Role in Vascular Repair and Regeneration. 61
30128229 2018
29
Pudendal Neuromodulation as a Treatment for Persistent Genital Arousal Disorder-A Case Series. 61
28657994 2018
30
Retrospective Study of the Prevalence and Risk Factors of Clitoral Adhesions: Women's Health Providers Should Routinely Examine the Glans Clitoris. 61
29559206 2018
31
Restless Genital Syndrome Induced by Milnacipran. 61
29634583 2018
32
An Online Cross-Sectional Comparison of Women With Symptoms of Persistent Genital Arousal, Painful Persistent Genital Arousal, and Chronic Vulvar Pain. 61
29609914 2018
33
The specific effect of gallic acid on Escherichia coli biofilm formation by regulating pgaABCD genes expression. 61
29327068 2018
34
Symptom Characteristics and Medical History of an Online Sample of Women Who Experience Symptoms of Persistent Genital Arousal. 61
28459348 2018
35
Sexual Hallucinations in Schizophrenia Spectrum Disorders and Their Relation With Childhood Trauma. 61
29867612 2018
36
Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases. 61
29733030 2018
37
Clomipramine trial for treatment-resistant persistent genital arousal disorder: a case series. 61
28635538 2017
38
Case Reports of a Mother and Daughter Diagnosed With Persistent Genital Arousal Disorder. 61
27599029 2017
39
Persistent Genital Arousal Disorder-Fact or Fiction? 61
28262102 2017
40
Lamotrigine-induced persistent genital arousal disorder: An unusual side effect. 61
28139448 2017
41
Persistent genital arousal disorder - a case report. 61
28455899 2017
42
Diagnosis and Treatment of Persistent Genital Arousal Disorder. 61
29472831 2017
43
Polygalacturonase gene pgxB in Aspergillus niger is a virulence factor in apple fruit. 61
28257463 2017
44
Toward a More Evidence-Based Nosology and Nomenclature for Female Sexual Dysfunctions-Part II. 61
27843072 2016
45
Persistent Genital Arousal Disorder: A Review of Its Conceptualizations, Potential Origins, Impact, and Treatment. 61
27461894 2016
46
Persistent Genital Arousal Disorder-Case Report of Symptomatic Relief of Symptoms With Transcranial Magnetic Stimulation. 61
26796498 2016
47
Sacral Neuromodulation for the Treatment of Persistent Genital Arousal Disorder. 61
27399995 2016
48
Persistent Genital Arousal Disorder. 61
27570347 2016
49
Combined site-specific sacral neuromodulation and pudendal nerve release surgery in a patient with interstitial cystitis and persistent arousal. 61
27284095 2016
50
Development of an Acid-Resistant Salmonella Typhi Ty21a Attenuated Vector For Improved Oral Vaccine Delivery. 61
27673328 2016

Variations for Persistent Genital Arousal Disorder

Expression for Persistent Genital Arousal Disorder

Search GEO for disease gene expression data for Persistent Genital Arousal Disorder.

Pathways for Persistent Genital Arousal Disorder

GO Terms for Persistent Genital Arousal Disorder

Sources for Persistent Genital Arousal Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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