AFP
MCID: PRS120
MIFTS: 28

Persistent Idiopathic Facial Pain (AFP)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Persistent Idiopathic Facial Pain

MalaCards integrated aliases for Persistent Idiopathic Facial Pain:

Name: Persistent Idiopathic Facial Pain 58
Atypical Facial Pain 58 32
Pifp 58
Afp 58

Characteristics:

Orphanet epidemiological data:

58
persistent idiopathic facial pain
Prevalence: 1-9/100000 (Netherlands),1-9/100000 (Germany),1-5/10000 (Germany); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 32 G50.1
ICD10 via Orphanet 33 G50.1
Orphanet 58 ORPHA398147

Summaries for Persistent Idiopathic Facial Pain

MalaCards based summary : Persistent Idiopathic Facial Pain, also known as atypical facial pain, is related to alpha-fetoprotein deficiency and hepatoblastoma. The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes.

Wikipedia : 74 Atypical facial pain (AFP) is a type of chronic facial pain which does not fulfill any other diagnosis.... more...

Related Diseases for Persistent Idiopathic Facial Pain

Diseases related to Persistent Idiopathic Facial Pain via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 430)
# Related Disease Score Top Affiliating Genes
1 alpha-fetoprotein deficiency 12.2
2 hepatoblastoma 12.0
3 testicular seminoma 12.0
4 spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 11.8
5 ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia 11.8
6 ataxia-telangiectasia 11.7
7 ventriculomegaly with cystic kidney disease 11.6
8 hepatocellular carcinoma 11.6
9 gastric cancer 11.6
10 neural tube defects 11.5
11 liver cirrhosis 11.5
12 liver disease 11.5
13 teratoma 11.5
14 embryonal carcinoma 11.5
15 hepatitis c 11.5
16 hepatitis b 11.5
17 down syndrome 11.5
18 hepatitis 11.5
19 testicular cancer 11.5
20 alpha-fetoprotein, hereditary persistence of 11.4
21 germ cell cancer 11.4
22 gastric adenocarcinoma 11.4
23 seminoma 11.4
24 anencephaly 11.4
25 testicular germ cell tumor 11.4
26 pre-eclampsia 11.4
27 viral hepatitis 11.4
28 ovarian cancer 11.4
29 poliomyelitis 11.4
30 endodermal sinus tumor 11.4
31 gallbladder cancer 11.4
32 oligohydramnios 11.4
33 sertoli-leydig cell tumor 11.4
34 tyrosinemia 11.4
35 testicular yolk sac tumor 11.4
36 tyrosinemia, type i 11.4
37 germinoma 11.4
38 hepatoid adenocarcinoma 11.4
39 acinar cell carcinoma 11.3
40 cholangiocarcinoma 11.3
41 dysgerminoma 11.3
42 intrahepatic cholangiocarcinoma 11.3
43 omphalocele 11.3
44 portal vein thrombosis 11.3
45 mature teratoma 11.3
46 tubular adenocarcinoma 11.3
47 placenta disease 11.3
48 leydig cell tumor 11.3
49 placental insufficiency 11.3
50 nephrotic syndrome, type 1 11.3

Graphical network of the top 20 diseases related to Persistent Idiopathic Facial Pain:



Diseases related to Persistent Idiopathic Facial Pain

Symptoms & Phenotypes for Persistent Idiopathic Facial Pain

Drugs & Therapeutics for Persistent Idiopathic Facial Pain

Drugs for Persistent Idiopathic Facial Pain (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
3
Acetaminophen Approved Phase 2 103-90-2 1983
4
Ibuprofen Approved Phase 2 15687-27-1 3672
5 abobotulinumtoxinA Phase 2
6 Cholinergic Agents Phase 2
7 Pharmaceutical Solutions Phase 2
8 Neurotransmitter Agents Phase 2
9 Botulinum Toxins Phase 2
10 Botulinum Toxins, Type A Phase 2
11 Sodium Channel Blockers Phase 2
12 Anesthetics Phase 2
13 Anti-Arrhythmia Agents Phase 2
14 Anesthetics, Local Phase 2
15 Diuretics, Potassium Sparing Phase 2
16
Pregabalin Approved, Investigational 148553-50-8 5486971
17
Gabapentin Approved, Investigational 60142-96-3 3446
18
Carbamazepine Approved, Investigational 298-46-4 2554
19 Analgesics, Non-Narcotic
20 Antidepressive Agents
21 Narcotics
22 Analgesics
23 Analgesics, Opioid
24
dipyrone 522325
25 Anticonvulsants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Double Blind, Randomized, Placebo Controlled, Safety and Efficacy Study of ATNC05 in Patients With Atypical Facial Pain With an Open-Label Extension Phase for Nonresponders Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
2 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Patients With Persistent Idiopathic Facial Pain: a Randomized, Double-blind, Cross- Over, Placebo-controlled Pilot Study Recruiting NCT03462290 Phase 2 botulinum toxin type A;placebo
3 A Multicenter Double Blinded Randomized Controlled Trial of the Efficacy of the Sphenopalatine Ganglion Block for the Treatment of the Postdural Puncture Headache After Labor Epidural Enrolling by invitation NCT03560349 Phase 2 Lidocaine HCl Gel 2%;placebo gel
4 Assessment and Treatment Patients With Atypical Facial Pain Trough Repetitive Transcranial Magnetic Stimulation Completed NCT01746355
5 Long-term Opioid Therapy, Misuse and Mortality in Patients With Chronic Non-cancer Pain in Germany Completed NCT03778450 Analgesics, Opioid;Non-Opioid Analgesic

Search NIH Clinical Center for Persistent Idiopathic Facial Pain

Genetic Tests for Persistent Idiopathic Facial Pain

Anatomical Context for Persistent Idiopathic Facial Pain

MalaCards organs/tissues related to Persistent Idiopathic Facial Pain:

40
Brain, Cortex, Testes, Bone, Lung, Hypothalamus, Eye

Publications for Persistent Idiopathic Facial Pain

Articles related to Persistent Idiopathic Facial Pain:

(show top 50) (show all 388)
# Title Authors PMID Year
1
Case Series: Deep Brain Stimulation for Facial Pain. 61
32542398 2020
2
Predictive role of gnathological techniques for the treatment of persistent idiopathic facial pain (PIFP). 61
32440980 2020
3
Differences in the Clinical Characteristics of Persistent Idiopathic Facial Pain (Atypical Odontalgia) Patients with or Without Neurovascular Compression of the Trigeminal Nerve. 61
32040150 2020
4
A case of an elderly patient with persistent idiopathic facial pain related to dental implants successfully treated with mirtazapine. 61
32162411 2020
5
Dynamic Internal Jugular Vein Compression by Hypertrophic Hyoid Bone: Management and Outcomes. 61
32351824 2020
6
Atypical Facial Pain. 61
31735230 2020
7
Persistent Idiopathic Facial Pain Originating from Cervical Abnormalities. 61
31629148 2020
8
Bilateral Atypical Facial Pain Caused by Eagle's Syndrome. 61
32181021 2020
9
Great Auricular Neuralgia: Case Series. 61
31749202 2020
10
Persistent dentoalveolar pain disorder: A putative intraoral chronic overlapping pain condition. 61
31797486 2019
11
Factors Associated With Long-term Risk of Recurrence After Percutaneous Radiofrequency Thermocoagulation of the Gasserian Ganglion for Patients With Trigeminal Neuralgia: A Multicenter Retrospective Analysis. 61
31490204 2019
12
The specialist management of non-temporomandibular orofacial pain: maxillofacial surgery's known unknown? 61
31307826 2019
13
Suspected trigeminal nerve neuropathy causing persistent idiopathic facial pain: a report of four cases. 61
31564751 2019
14
Update on Trigeminal Neuralgia. 61
31367794 2019
15
Neuralgia-inducing cavitational osteonecrosis - Fact or myth, the debate persists. 61
31798261 2019
16
Percutaneous Trigeminal Nerve Stimulation for Persistent Idiopathic Facial Pain: A Case Series. 61
30902776 2019
17
Diagnostic delay and suboptimal management in persistent idiopathic facial pain and persistent dentoalveolar pain; a cross-sectional study. 61
30956081 2019
18
The role of electrophysiological investigations of masticatory muscles in patients with persistent idiopathic facial pain. 61
30825018 2019
19
Oral medicine psychiatric liaison clinic: study of 1202 patients attending over an 18-year period. 61
30609954 2019
20
Altered cortical excitability in persistent idiopathic facial pain. 61
29898612 2019
21
Psychological Interventions for Persistent Orofacial Pain. 61
30835664 2019
22
Persistent Idiopathic Facial Pain Associated with Somatoform Disorder in an 11-Year-Old Boy. 61
30881720 2019
23
Surgical Management of Trigeminal Neuralgia in Children. 61
30347302 2019
24
Patterns of opioid use in patients with trigeminal neuralgia undergoing neurosurgery. 61
30641832 2019
25
Near-resolution of persistent idiopathic facial pain with low-dose lumbar intrathecal ziconotide: a case report. 61
30881103 2019
26
Neuropathic Characteristics In Patients With Persistent Idiopathic Facial Pain. 61
31632129 2019
27
[Burning mouth syndrome]. 61
30778036 2019
28
Tooth Ache to Leprosy! Importance of Revisiting Diagnosis. 61
30344381 2018
29
Time course of the response to navigated repetitive transcranial magnetic stimulation at 10 Hz in chronic neuropathic pain. 61
29583099 2018
30
Sexual Dysfunctions Induced by Pregabalin. 61
30001248 2018
31
Comparing spiking and slow wave activity from invasive electroencephalography in patients with and without seizures. 61
29550651 2018
32
Persistent Dentoalveolar Pain Disorder: A Comprehensive Review. 61
29174443 2018
33
Fluoroscopic C-Arm and CT-Guided Selective Radiofrequency Ablation for Trigeminal and Glossopharyngeal Facial Pain Syndromes. 61
28472393 2018
34
Non-invasive brain stimulation in chronic orofacial pain: a systematic review. 61
30122975 2018
35
[Neurophysiological assessment of persistent idiopathic facial pain]. 61
30251980 2018
36
Orofacial pain - an update on diagnosis and management. 61
29074941 2017
37
Treatment of Facial Pain with I Ching Balance Acupuncture. 61
29279736 2017
38
Persistent idiopathic facial pain - a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI. 61
27789649 2017
39
External Nasal Neuralgia: an Update. 61
28900824 2017
40
Somatoform Pain Disorder Presenting as "Atypical Facial Pain:" A Rare Presentation in a 13-year-old. 61
28852247 2017
41
History of facial pain diagnosis. 61
28181442 2017
42
Persistent idiopathic facial pain. 61
28425324 2017
43
Usefulness of an occlusal device in the treatment of medication overuse headache and persistent idiopathic facial pain: preliminary results. 61
28527082 2017
44
Balloon dilation of sinus ostia in the Department of Defense: Diagnoses, actual indications, and outcomes. 61
27659163 2017
45
Atypical Facial Pain: a Comprehensive, Evidence-Based Review. 61
28251523 2017
46
Neuronavigated percutaneous approach to the sphenopalatine ganglion. 61
27104840 2017
47
Staged Bilateral Nucleus Caudalis DREZ Lesioning for Persistent Idiopathic Facial Pain: Exceptional Case Report. 61
27349397 2017
48
Cracked tooth syndrome mimicking trigeminal autonomic cephalalgia: A report of four cases. 61
28168240 2017
49
Therapeutic potential of stellate ganglion block in orofacial pain: a mini review. 61
28884148 2016
50
Botulinum Neurotoxin Type-A for the Treatment of Atypical Odontalgia. 61
27073225 2016

Variations for Persistent Idiopathic Facial Pain

Expression for Persistent Idiopathic Facial Pain

Search GEO for disease gene expression data for Persistent Idiopathic Facial Pain.

Pathways for Persistent Idiopathic Facial Pain

GO Terms for Persistent Idiopathic Facial Pain

Sources for Persistent Idiopathic Facial Pain

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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