MCID: PRS064
MIFTS: 30

Persistent Vegetative State

Categories: Neuronal diseases

Aliases & Classifications for Persistent Vegetative State

MalaCards integrated aliases for Persistent Vegetative State:

Name: Persistent Vegetative State 54 55 73

Classifications:



External Ids:

UMLS 73 C0242670

Summaries for Persistent Vegetative State

NINDS : 54 A coma, sometimes also called persistent vegetative state, is a profound or deep state of unconsciousness. Persistent vegetative state is not brain-death. An individual in a state of coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as head trauma. . Individuals in such a state have lost their thinking abilities and awareness of their surroundings, but retain non-cognitive function and normal sleep patterns. Even though those in a persistent vegetative state lose their higher brain functions, other key functions such as breathing and circulation remain relatively intact. Spontaneous movements may occur, and the eyes may open in response to external stimuli. Individuals may even occasionally grimace, cry, or laugh. Although individuals in a persistent vegetative state may appear somewhat normal, they do not speak and they are unable to respond to commands.

MalaCards based summary : Persistent Vegetative State is related to traumatic brain injury and brain injury, and has symptoms including syncope, transient alteration of awareness and other alteration of consciousness. An important gene associated with Persistent Vegetative State is SLC25A22 (Solute Carrier Family 25 Member 22), and among its related pathways/superpathways are Glucose / Energy Metabolism and Neuroscience. The drugs Midazolam and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and bone, and related phenotype is taste/olfaction.

Wikipedia : 76 A persistent vegetative state (PVS) is a disorder of consciousness in which patients with severe brain... more...

Related Diseases for Persistent Vegetative State

Diseases related to Persistent Vegetative State via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 30.1 APOE ENO2
2 brain injury 30.1 APOE ENO2
3 head injury 29.9 APOE ENO2
4 ocular motor apraxia 11.8
5 panencephalitis, subacute sclerosing 11.3
6 epileptic encephalopathy, early infantile, 3 11.3
7 dementia 10.1
8 vascular dementia 10.0
9 hypoglycemia 10.0
10 alzheimer disease 9.8
11 multiple sclerosis 9.8
12 anencephaly 9.8
13 diabetes mellitus, ketosis-prone 9.8
14 locked-in syndrome 9.8
15 ischemia 9.8
16 dystonia 9.8
17 kidney disease 9.8
18 encephalitis 9.8
19 creutzfeldt-jakob disease 9.8 APOE ENO2
20 nervous system disease 9.8 APOE ENO2
21 hydrocephalus 9.8 APOE ENO2
22 stroke, ischemic 9.7 APOE ENO2

Comorbidity relations with Persistent Vegetative State via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Heart Disease

Graphical network of the top 20 diseases related to Persistent Vegetative State:



Diseases related to Persistent Vegetative State

Symptoms & Phenotypes for Persistent Vegetative State

UMLS symptoms related to Persistent Vegetative State:


syncope, transient alteration of awareness, other alteration of consciousness

MGI Mouse Phenotypes related to Persistent Vegetative State:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 APOE ENO2

Drugs & Therapeutics for Persistent Vegetative State

Drugs for Persistent Vegetative State (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
3
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
4 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
5 Analgesics, Non-Narcotic Phase 4,Not Applicable
6 Analgesics Phase 4,Phase 2,Not Applicable
7 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
8 Anesthetics, General Phase 4
9 GABA Modulators Phase 4
10 Anti-Anxiety Agents Phase 4
11 Adjuvants, Anesthesia Phase 4
12 Adrenergic Agents Phase 4
13 Adrenergic Agonists Phase 4
14 Hypnotics and Sedatives Phase 4
15 Central Nervous System Depressants Phase 4,Phase 2
16 Adrenergic alpha-2 Receptor Agonists Phase 4
17 Adrenergic alpha-Agonists Phase 4
18 Anesthetics Phase 4,Phase 2
19 Anesthetics, Intravenous Phase 4
20 Tranquilizing Agents Phase 4
21 Psychotropic Drugs Phase 4
22 GABA Agents Phase 4
23
Dopamine Approved Phase 2,Not Applicable 51-61-6, 62-31-7 681
24
Apomorphine Approved, Investigational Phase 2 41372-20-7, 58-00-4 6005
25
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2 7487-88-9 24083
26 Dopamine Agents Phase 2,Not Applicable
27 Pharmaceutical Solutions Phase 2,Phase 1
28 Gastrointestinal Agents Phase 2
29 Dopamine agonists Phase 2
30 Autonomic Agents Phase 2
31 Emetics Phase 2
32 Anticonvulsants Phase 2
33 calcium channel blockers Phase 2
34 Anti-Arrhythmia Agents Phase 2
35 Tocolytic Agents Phase 2
36 Calcium, Dietary Phase 2
37
Amantadine Approved Not Applicable 768-94-5 2130
38
Atracurium Approved, Experimental, Investigational 64228-79-1 47319
39
Cisatracurium Approved 96946-41-7
40
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
41
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
42 tannic acid Approved Not Applicable
43
Zaleplon Approved, Illicit, Investigational Not Applicable 151319-34-5 5719
44 Antiviral Agents Not Applicable
45 Anti-Infective Agents Not Applicable
46 Antiparkinson Agents Not Applicable
47 Cholinergic Antagonists
48 Neuromuscular Nondepolarizing Agents
49 Cholinergic Agents
50 Neuromuscular Blocking Agents

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State Unknown status NCT00163878 Phase 4
2 Dexmedetomidine vs Midazolam for Intraoperative Sedation Completed NCT02878837 Phase 4 Dexmedetomidine;Midazolam
3 Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury Unknown status NCT01260090 Phase 3
4 Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients Recruiting NCT03007784 Phase 3
5 Thalamic Stimulation of Patients in Vegetative or Minimally Conscious State Unknown status NCT01027572 Phase 2
6 tDCS on Precuneus in MCS: Repeated Stimulations Completed NCT02702362 Phase 2
7 Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness Completed NCT01673126 Phase 2
8 The Efficacy of Familiar Voice Stimulation During Coma Recovery Completed NCT00557076 Phase 1, Phase 2
9 Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury Suspended NCT00761228 Phase 2 Apomorphine;Placebo
10 Mild Hypothermia and Supplemental Magnesium Sulfate Infusion in Severe Traumatic Brain Injury (TBI) Subjects Terminated NCT01333488 Phase 2 Magnesium Sulfate
11 The Impact of RPh201 on CVS Patients: Clinical and fMRI Measurements Withdrawn NCT01417299 Phase 1, Phase 2
12 Carbonic Anhydrase Antagonism in Subarachnoid Hemorrhage Withdrawn NCT02165644 Phase 2 Acetazolamide;Nimodipine
13 Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC Completed NCT03797573 Phase 1
14 The Impact of RPh201 on Chronic Vegetative State (CVS): fMRI Study Suspended NCT01438684 Phase 1 RPh201;Saline
15 Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study Unknown status NCT02566720 Not Applicable Amantadine
16 Study of Survivors of Different Types of Cardiac Arrest and Their Neurological Recovery Unknown status NCT02033720
17 When Cooling a Patient After Cardiac Arrest, Does Use of a Neuromuscular Blocking Agent Make Your Job Easier? Unknown status NCT02033733 Cisatracurium infusion;Cisatracurium prn bolus
18 Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury Completed NCT02629588
19 18F-FDG PET/CT in Diagnostic Patients of Disorder of Consciousness Completed NCT02999490 Not Applicable
20 A Study to Tailor Advance Directives Completed NCT00121004
21 Reliability and Validity of the NCS (NCS-R)-Chinese Version Completed NCT03494218 Not Applicable
22 Further Psychometric Data for the Reliability and the Diagnostic Validity of CRS-R Completed NCT03126929
23 Personalized Objects Can Improve the Diagnosis of EMCS From MCS Completed NCT02988206 Not Applicable
24 Pupil Near Response in UWS Patients Completed NCT02832492
25 Transcranial Brain Stimulation in Vegetative State Patients Completed NCT01820923 Not Applicable
26 Cerebral Oxygenation in Cardiac Arrest and Hypothermia Completed NCT01531426
27 Transcranial Direct Current Stimulation Effects in Patients With Chronic Consciousness Disorders Completed NCT02288533 Not Applicable
28 The Initiation of Swallowing Can Indicate the Prognosis of DOC Completed NCT03508336
29 The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study Completed NCT03492294
30 Analysis of Vital, Facial and Muscular Responses Front to Music or Message in Coma, Vegetative State or Sedated Patients Completed NCT01141790 Not Applicable
31 Navigated Brain Stimulation in Diagnosis of Minimally Conscious State Completed NCT01467908 Not Applicable
32 Measuring and Treating Brain Oxygen Levels in Open Heart Surgery Completed NCT01539382 Not Applicable
33 Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness Completed NCT02626403 Not Applicable
34 tDCS in MCS: Repeated Stimulations Completed NCT02019615 Not Applicable
35 Study of Conscious Behavior Under Low-frequency Deep Brain Stimulation in Chronic and Severe Post-coma Disorders of Consciousness Completed NCT01718249 Not Applicable
36 Temperature Control With an Esophageal Cooling Device in Post Cardiac Arrest Patients Completed NCT02387775 Not Applicable
37 Seprafilm in Open Abdomens: a Study of Wound and Adhesion Characteristics in Trauma Damage Control Patients Completed NCT01594385 Not Applicable
38 Resuscitation Registry - Surrogate Markers of Outcome After Cardiac Arrest Recruiting NCT02722460
39 Status Epilepticus in the Critically Ill Patients Recruiting NCT03457831
40 Posterior Reversible Encephalopathy Syndrome in the Critically Ill Patients Recruiting NCT03470467
41 Versailles Hospital Cardiac Arrest Registry Recruiting NCT03594318
42 Early DiaGnosis of Anoxic Brain Injury for Resuscitated Patients Recruiting NCT03806660
43 Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia Recruiting NCT03024021
44 Effects of Whole-body Vibration Exercise in Brain Injury Patients With Minimally Conscious State Recruiting NCT03389113 Not Applicable
45 Thromboelastometry-identified Haemostatic Changes in Isolated Traumatic Brain Injury Recruiting NCT03616808 Not Applicable
46 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069 Not Applicable
47 tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury Recruiting NCT03367078
48 The Effects of Olfactory Stimulation on Diagnosis and Prognosis of DOC Patients Active, not recruiting NCT03732092
49 BRIEF TITLE (en Anglais) : Emotion Assessment to Study Consciousness in Awakening Patients Not yet recruiting NCT03706170 Not Applicable
50 Closed-loop tDCS in Patients in Minimally Conscious State Not yet recruiting NCT03810079 Not Applicable

Search NIH Clinical Center for Persistent Vegetative State

Genetic Tests for Persistent Vegetative State

Anatomical Context for Persistent Vegetative State

MalaCards organs/tissues related to Persistent Vegetative State:

41
Brain, Eye, Bone, Heart, Kidney, Spinal Cord, Bone Marrow

Publications for Persistent Vegetative State

Articles related to Persistent Vegetative State:

(show top 50) (show all 332)
# Title Authors Year
1
Provision of renal care for patients with end stage kidney disease in persistent vegetative state, in United Arab Emirates: a national survey of renal physicians. ( 29979643 )
2018
2
The effectiveness of non-invasive brain stimulation on arousal and alertness in patients in coma or persistent vegetative state after traumatic brain injury: Protocol of systematic review and network meta-analysis. ( 30212977 )
2018
3
A Case of Persistent Vegetative State after Diabetic Ketoacidosis Triggered by an Overdose of Psychotropic Agents. ( 30210110 )
2018
4
Prevalence of persistent vegetative state in patients with severe traumatic brain injury and its trend during the past four decades: A meta-analysis. ( 27814303 )
2017
5
Treatment of a Pregnant Patient in a Persistent Vegetative State. ( 27926646 )
2017
6
Recovery from Chronic Diseases of Consciousness: State of the Art in Neuromodulation for Persistent Vegetative State and Minimally Conscious State. ( 28120048 )
2017
7
Effects of percutaneous endoscopic gastrostomy on survival of patients in a persistent vegetative state after stroke. ( 27878869 )
2017
8
Evaluation of nursing interventions using minimally invasive assessments methods for patients in a persistent vegetative state. ( 28378507 )
2017
9
Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative state: a case report. ( 28791670 )
2017
10
Persistent vegetative state and minimally conscious state: ethical, legal and practical dilemmas. ( 28663409 )
2017
11
Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage. ( 28739616 )
2017
12
Ascending Reticular Activating System in a Patient with Persistent Vegetative State. ( 26745220 )
2016
13
Effectiveness of Sensory Stimulation to Improve Arousal and Alertness of People in a Coma or Persistent Vegetative State After Traumatic Brain Injury: A Systematic Review. ( 27089287 )
2016
14
Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells via Ommaya Reservoir in Persistent Vegetative State Patients after Haemorrhagic Stroke: Report of Two Cases & Review of the Literature. ( 28096634 )
2016
15
Open traumatic brain injury by nail gun resulting in a persistent vegetative state. ( 27044613 )
2016
16
Persistent vegetative state and minimally conscious state. ( 25891806 )
2015
17
Magnetic resonance imaging characteristics of persistent vegetative state due to prolonged hypoglycemia. ( 25738058 )
2015
18
Should patients in a persistent vegetative state be allowed to die? Guidelines for a new standard of care in Australian hospitals. ( 26507136 )
2015
19
Brainstem neurons survive the identical ischemic stress that kills higher neurons: insight to the persistent vegetative state. ( 24802253 )
2014
20
Zolpidem Arousing Effect In Persistent Vegetative State Patients: Autonomic, Eeg And Behavioral Assessment. ( 24025063 )
2013
21
Ethics and Health Policy of Dialyzing a Patient in a Persistent Vegetative State. ( 24115197 )
2013
22
Causes and outcomes of persistent vegetative state in a Chinese versus American referral hospital. ( 23099847 )
2013
23
From hope to despair, and back: being the wife of a patient in a persistent vegetative state. ( 23188382 )
2013
24
Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state. ( 22047598 )
2012
25
Court case adjourned after diagnosis of persistent vegetative state changes. ( 22930714 )
2012
26
A Cuban perspective on management of persistent vegetative state. ( 22334112 )
2012
27
Responsiveness of a patient in a persistent vegetative state after a coma to weekly injections of autologous activated immune cells: a case report. ( 22234176 )
2012
28
Persistent vegetative state: an ethical reappraisal. ( 22131038 )
2012
29
Measuring interconnection of the residual cortical functional islands in persistent vegetative state and minimal conscious state with EEG nonlinear analysis. ( 21530389 )
2011
30
More dead than dead: perceptions of persons in the persistent vegetative state. ( 21798528 )
2011
31
Characteristics of infradian and circadian rhythms in the persistent vegetative state. ( 22289544 )
2011
32
A long-term intensive behavioral treatment study in patients with persistent vegetative state or minimally conscious state. ( 21305239 )
2011
33
In the name of good intentions: nurses' perspectives on caring for a pregnant patient in a persistent vegetative state. ( 20124019 )
2010
34
Persistent vegetative state. ( 20132712 )
2010
35
Zolpidem for persistent vegetative state--a placebo-controlled trial in pediatrics. ( 21210338 )
2010
36
The place of L-dopa/carbidopa in persistent vegetative state. ( 21060281 )
2010
37
Covert cognition in the persistent vegetative state. ( 20138110 )
2010
38
Are people in a persistent vegetative state conscious? ( 20069822 )
2009
39
Response to Kanno eta88al. "Dorsal Column Stimulation in Persistent Vegetative State". ( 22151423 )
2009
40
Intrathecal baclofen in patients with persistent vegetative state: 2 hypotheses. ( 19577040 )
2009
41
Dorsal column stimulation in persistent vegetative state. ( 22151220 )
2009
42
Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients. ( 19299197 )
2009
43
Media coverage of the persistent vegetative state and end-of-life decision-making: Theresa Schiavo's tragedy and ours, too. ( 19752461 )
2009
44
Prevention of venous thromboembolism and persistent vegetative state: A medical and an ethical issue. ( 18549951 )
2008
45
Media coverage of the persistent vegetative state and end-of-life decision-making. ( 18685135 )
2008
46
A MRS-MRI-fMRI exploration of the brain. Impact of long-lasting persistent vegetative state. ( 18240041 )
2008
47
Persistent vegetative state in electrical injuries: a 10-year review. ( 17913369 )
2008
48
Heart rate non linear dynamics in patients with persistent vegetative state: a preliminary report. ( 18183507 )
2008
49
Caring for children in a persistent vegetative state: complex but manageable. ( 17873785 )
2007
50
The experiences of pediatric nurses caring for children in a persistent vegetative state. ( 17693906 )
2007

Variations for Persistent Vegetative State

Expression for Persistent Vegetative State

Search GEO for disease gene expression data for Persistent Vegetative State.

Pathways for Persistent Vegetative State

Pathways related to Persistent Vegetative State according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.45 APOE ENO2
2 11.33 APOE ENO2 GABBR1

GO Terms for Persistent Vegetative State

Sources for Persistent Vegetative State

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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