Aliases & Classifications for Persistent Vegetative State

MalaCards integrated aliases for Persistent Vegetative State:

Name: Persistent Vegetative State 54 55 73

External Ids:

UMLS 73 C0242670

Summaries for Persistent Vegetative State

MalaCards based summary : Persistent Vegetative State is related to traumatic brain injury and brain injury, and has symptoms including syncope, transient alteration of awareness and other alteration of consciousness. An important gene associated with Persistent Vegetative State is SLC25A22 (Solute Carrier Family 25 Member 22), and among its related pathways/superpathways are Glucose / Energy Metabolism and Neuroscience. The drugs Midazolam and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related phenotype is taste/olfaction.

Wikipedia : 76 A persistent vegetative state (PVS) is a disorder of consciousness in which patients with severe brain... more...

Related Diseases for Persistent Vegetative State

Diseases related to Persistent Vegetative State via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 29.7 APOE ENO2
2 brain injury 29.7 APOE ENO2
3 head injury 29.6 APOE ENO2
4 ocular motor apraxia 11.3
5 panencephalitis, subacute sclerosing 11.2
6 epileptic encephalopathy, early infantile, 3 11.2
7 cerebritis 10.2
8 dementia 10.0
9 vascular dementia 9.9
10 hypoglycemia 9.9
11 alzheimer disease 9.7
12 multiple sclerosis 9.7
13 encephalitis 9.7
14 anencephaly 9.7
15 anoxia 9.7
16 locked-in syndrome 9.7
17 ischemia 9.7
18 sleep disorder 9.7
19 dystonia 9.7
20 kidney disease 9.7
21 neuronitis 9.7
22 creutzfeldt-jakob disease 9.6 APOE ENO2
23 hydrocephalus 9.5 APOE ENO2
24 stroke, ischemic 9.2 APOE ENO2

Comorbidity relations with Persistent Vegetative State via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Heart Disease

Graphical network of the top 20 diseases related to Persistent Vegetative State:



Diseases related to Persistent Vegetative State

Symptoms & Phenotypes for Persistent Vegetative State

UMLS symptoms related to Persistent Vegetative State:


syncope, transient alteration of awareness, other alteration of consciousness

MGI Mouse Phenotypes related to Persistent Vegetative State:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 APOE ENO2

Drugs & Therapeutics for Persistent Vegetative State

Drugs for Persistent Vegetative State (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4 Analgesics Phase 4,Phase 2,Not Applicable
5 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
6 Analgesics, Non-Narcotic Phase 4,Not Applicable
7 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
8 Central Nervous System Depressants Phase 4,Phase 2
9 Adjuvants, Anesthesia Phase 4
10 Adrenergic Agents Phase 4
11 Adrenergic Agonists Phase 4
12 Adrenergic alpha-2 Receptor Agonists Phase 4
13 Adrenergic alpha-Agonists Phase 4
14 GABA Agents Phase 4
15 GABA Modulators Phase 4
16 Anesthetics Phase 4,Phase 2
17 Anesthetics, General Phase 4
18 Anesthetics, Intravenous Phase 4
19 Tranquilizing Agents Phase 4
20 Anti-Anxiety Agents Phase 4
21 Hypnotics and Sedatives Phase 4
22 Psychotropic Drugs Phase 4
23
Dopamine Approved Phase 2,Not Applicable 51-61-6, 62-31-7 681
24
Apomorphine Approved, Investigational Phase 2 41372-20-7, 58-00-4 6005
25
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2 7487-88-9 24083
26 Dopamine Agents Phase 2,Not Applicable
27 Dopamine agonists Phase 2
28 Gastrointestinal Agents Phase 2
29 Emetics Phase 2
30 Pharmaceutical Solutions Phase 2,Phase 1
31 Autonomic Agents Phase 2
32 calcium channel blockers Phase 2
33 Tocolytic Agents Phase 2
34 Anti-Arrhythmia Agents Phase 2
35 Anticonvulsants Phase 2
36 Calcium, Dietary Phase 2
37
Menthol Approved Not Applicable 2216-51-5 16666
38
Atracurium Approved, Experimental, Investigational 64228-79-1 47319
39
Cisatracurium Approved 96946-41-7
40
Amantadine Approved Not Applicable 768-94-5 2130
41
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
42
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
43 tannic acid Approved, Nutraceutical Not Applicable
44 Cholinergic Agents
45 Cholinergic Antagonists
46 Neuromuscular Agents
47 Neuromuscular Blocking Agents
48 Neuromuscular Nondepolarizing Agents
49 Anti-Infective Agents Not Applicable
50 Antiparkinson Agents Not Applicable

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State Unknown status NCT00163878 Phase 4
2 Dexmedetomidine vs Midazolam for Intraoperative Sedation Completed NCT02878837 Phase 4 Dexmedetomidine;Midazolam
3 Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury Unknown status NCT01260090 Phase 3
4 Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients Recruiting NCT03007784 Phase 3
5 Thalamic Stimulation of Patients in Vegetative or Minimally Conscious State Unknown status NCT01027572 Phase 2
6 tDCS on Precuneus in MCS: Repeated Stimulations Completed NCT02702362 Phase 2
7 Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness Completed NCT01673126 Phase 2
8 The Efficacy of Familiar Voice Stimulation During Coma Recovery Completed NCT00557076 Phase 1, Phase 2
9 Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury Suspended NCT00761228 Phase 2 Apomorphine;Placebo
10 Mild Hypothermia and Supplemental Magnesium Sulfate Infusion in Severe Traumatic Brain Injury (TBI) Subjects Terminated NCT01333488 Phase 2 Magnesium Sulfate
11 The Impact of RPh201 on CVS Patients: Clinical and fMRI Measurements Withdrawn NCT01417299 Phase 1, Phase 2
12 Carbonic Anhydrase Antagonism in Subarachnoid Hemorrhage Withdrawn NCT02165644 Phase 2 Acetazolamide;Nimodipine
13 The Impact of RPh201 on Chronic Vegetative State (CVS): fMRI Study Suspended NCT01438684 Phase 1 RPh201;Saline
14 Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study Unknown status NCT02566720 Not Applicable Amantadine
15 Study of Survivors of Different Types of Cardiac Arrest and Their Neurological Recovery Unknown status NCT02033720
16 When Cooling a Patient After Cardiac Arrest, Does Use of a Neuromuscular Blocking Agent Make Your Job Easier? Unknown status NCT02033733 Cisatracurium infusion;Cisatracurium prn bolus
17 Temperature Control With an Esophageal Cooling Device in Post Cardiac Arrest Patients Unknown status NCT02387775 Not Applicable
18 Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury Completed NCT02629588
19 18F-FDG PET/CT in Diagnostic Patients of Disorder of Consciousness Completed NCT02999490 Not Applicable
20 A Study to Tailor Advance Directives Completed NCT00121004
21 Reliability and Validity of the NCS (NCS-R)-Chinese Version Completed NCT03494218 Not Applicable
22 Further Psychometric Data for the Reliability and the Diagnostic Validity of CRS-R Completed NCT03126929
23 Personalized Objects Can Improve the Diagnosis of EMCS From MCS Completed NCT02988206 Not Applicable
24 Pupil Near Response in UWS Patients Completed NCT02832492
25 Transcranial Brain Stimulation in Vegetative State Patients Completed NCT01820923 Not Applicable
26 Cerebral Oxygenation in Cardiac Arrest and Hypothermia Completed NCT01531426
27 Transcranial Direct Current Stimulation Effects in Patients With Chronic Consciousness Disorders Completed NCT02288533 Not Applicable
28 The Initiation of Swallowing Can Indicate the Prognosis of DOC Completed NCT03508336
29 The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study Completed NCT03492294
30 Analysis of Vital, Facial and Muscular Responses Front to Music or Message in Coma, Vegetative State or Sedated Patients Completed NCT01141790 Not Applicable
31 Navigated Brain Stimulation in Diagnosis of Minimally Conscious State Completed NCT01467908 Not Applicable
32 Measuring and Treating Brain Oxygen Levels in Open Heart Surgery Completed NCT01539382 Not Applicable
33 Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness Completed NCT02626403 Not Applicable
34 tDCS in MCS: Repeated Stimulations Completed NCT02019615 Not Applicable
35 Study of Conscious Behavior Under Low-frequency Deep Brain Stimulation in Chronic and Severe Post-coma Disorders of Consciousness Completed NCT01718249 Not Applicable
36 Seprafilm in Open Abdomens: a Study of Wound and Adhesion Characteristics in Trauma Damage Control Patients Completed NCT01594385 Not Applicable
37 Resuscitation Registry - Surrogate Markers of Outcome After Cardiac Arrest Recruiting NCT02722460
38 Status Epilepticus in the Critically Ill Patients Recruiting NCT03457831
39 Posterior Reversible Encephalopathy Syndrome in the Critically Ill Patients Recruiting NCT03470467
40 Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia Recruiting NCT03024021
41 Effects of Whole-body Vibration Exercise in Brain Injury Patients With Minimally Conscious State Recruiting NCT03389113 Not Applicable
42 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069 Not Applicable
43 tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury Not yet recruiting NCT03367078

Search NIH Clinical Center for Persistent Vegetative State

Genetic Tests for Persistent Vegetative State

Anatomical Context for Persistent Vegetative State

MalaCards organs/tissues related to Persistent Vegetative State:

41
Brain, Heart, Liver, Thalamus, Pituitary, Kidney, Spinal Cord

Publications for Persistent Vegetative State

Articles related to Persistent Vegetative State:

(show top 50) (show all 320)
# Title Authors Year
1
Provision of renal care for patients with end stage kidney disease in persistent vegetative state, in United Arab Emirates: a national survey of renal physicians. ( 29979643 )
2018
2
Prevalence of persistent vegetative state in patients with severe traumatic brain injury and its trend during the past four decades: A meta-analysis. ( 27814303 )
2017
3
Treatment of a Pregnant Patient in a Persistent Vegetative State. ( 27926646 )
2017
4
Recovery from Chronic Diseases of Consciousness: State of the Art in Neuromodulation for Persistent Vegetative State and Minimally Conscious State. ( 28120048 )
2017
5
Effects of percutaneous endoscopic gastrostomy on survival of patients in a persistent vegetative state after stroke. ( 27878869 )
2017
6
Evaluation of nursing interventions using minimally invasive assessments methods for patients in a persistent vegetative state. ( 28378507 )
2017
7
Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative state: a case report. ( 28791670 )
2017
8
Persistent vegetative state and minimally conscious state: ethical, legal and practical dilemmas. ( 28663409 )
2017
9
Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage. ( 28739616 )
2017
10
Ascending Reticular Activating System in a Patient with Persistent Vegetative State. ( 26745220 )
2016
11
Effectiveness of Sensory Stimulation to Improve Arousal and Alertness of People in a Coma or Persistent Vegetative State After Traumatic Brain Injury: A Systematic Review. ( 27089287 )
2016
12
Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells via Ommaya Reservoir in Persistent Vegetative State Patients after Haemorrhagic Stroke: Report of Two Cases & Review of the Literature. ( 28096634 )
2016
13
Open traumatic brain injury by nail gun resulting in a persistent vegetative state. ( 27044613 )
2016
14
Persistent vegetative state and minimally conscious state. ( 25891806 )
2015
15
Magnetic resonance imaging characteristics of persistent vegetative state due to prolonged hypoglycemia. ( 25738058 )
2015
16
Should patients in a persistent vegetative state be allowed to die? Guidelines for a new standard of care in Australian hospitals. ( 26507136 )
2015
17
Brainstem neurons survive the identical ischemic stress that kills higher neurons: insight to the persistent vegetative state. ( 24802253 )
2014
18
Zolpidem Arousing Effect In Persistent Vegetative State Patients: Autonomic, Eeg And Behavioral Assessment. ( 24025063 )
2013
19
Ethics and Health Policy of Dialyzing a Patient in a Persistent Vegetative State. ( 24115197 )
2013
20
Causes and outcomes of persistent vegetative state in a Chinese versus American referral hospital. ( 23099847 )
2013
21
From hope to despair, and back: being the wife of a patient in a persistent vegetative state. ( 23188382 )
2013
22
Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state. ( 22047598 )
2012
23
Court case adjourned after diagnosis of persistent vegetative state changes. ( 22930714 )
2012
24
A Cuban perspective on management of persistent vegetative state. ( 22334112 )
2012
25
Responsiveness of a patient in a persistent vegetative state after a coma to weekly injections of autologous activated immune cells: a case report. ( 22234176 )
2012
26
Persistent vegetative state: an ethical reappraisal. ( 22131038 )
2012
27
Measuring interconnection of the residual cortical functional islands in persistent vegetative state and minimal conscious state with EEG nonlinear analysis. ( 21530389 )
2011
28
More dead than dead: perceptions of persons in the persistent vegetative state. ( 21798528 )
2011
29
Characteristics of infradian and circadian rhythms in the persistent vegetative state. ( 22289544 )
2011
30
A long-term intensive behavioral treatment study in patients with persistent vegetative state or minimally conscious state. ( 21305239 )
2011
31
In the name of good intentions: nurses' perspectives on caring for a pregnant patient in a persistent vegetative state. ( 20124019 )
2010
32
Persistent vegetative state. ( 20132712 )
2010
33
Zolpidem for persistent vegetative state--a placebo-controlled trial in pediatrics. ( 21210338 )
2010
34
The place of L-dopa/carbidopa in persistent vegetative state. ( 21060281 )
2010
35
Covert cognition in the persistent vegetative state. ( 20138110 )
2010
36
Are people in a persistent vegetative state conscious? ( 20069822 )
2009
37
Intrathecal baclofen in patients with persistent vegetative state: 2 hypotheses. ( 19577040 )
2009
38
Dorsal column stimulation in persistent vegetative state. ( 22151220 )
2009
39
Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients. ( 19299197 )
2009
40
Media coverage of the persistent vegetative state and end-of-life decision-making: Theresa Schiavo's tragedy and ours, too. ( 19752461 )
2009
41
Prevention of venous thromboembolism and persistent vegetative state: A medical and an ethical issue. ( 18549951 )
2008
42
Media coverage of the persistent vegetative state and end-of-life decision-making. ( 18685135 )
2008
43
A MRS-MRI-fMRI exploration of the brain. Impact of long-lasting persistent vegetative state. ( 18240041 )
2008
44
Persistent vegetative state in electrical injuries: a 10-year review. ( 17913369 )
2008
45
Heart rate non linear dynamics in patients with persistent vegetative state: a preliminary report. ( 18183507 )
2008
46
Caring for children in a persistent vegetative state: complex but manageable. ( 17873785 )
2007
47
The experiences of pediatric nurses caring for children in a persistent vegetative state. ( 17693906 )
2007
48
Recognizing a mother's voice in the persistent vegetative state. ( 17844939 )
2007
49
Dorsal column stimulation for persistent vegetative state. ( 17691409 )
2007
50
Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state. ( 17691381 )
2007

Variations for Persistent Vegetative State

Expression for Persistent Vegetative State

Search GEO for disease gene expression data for Persistent Vegetative State.

Pathways for Persistent Vegetative State

Pathways related to Persistent Vegetative State according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.45 APOE ENO2
2 11.33 APOE ENO2 GABBR1

GO Terms for Persistent Vegetative State

Sources for Persistent Vegetative State

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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