MCID: PRT037
MIFTS: 71

Pertussis

Categories: Infectious diseases, Rare diseases, Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Pertussis

MalaCards integrated aliases for Pertussis:

Name: Pertussis 12 77 54 60 15 74 3 3
Whooping Cough 12 77 54 60 44 15 17 3
Bordetella Infections 45 17 74
Whooping Cough Due to Unspecified Organism 74
Bordetella Pertussis Infection 54
Bordetella Infection 12
Wc - Whooping Cough 12

Characteristics:

Orphanet epidemiological data:

60
whooping cough
Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1116
MeSH 45 D001885
SNOMED-CT 69 26484003
MESH via Orphanet 46 D014917
ICD10 via Orphanet 35 A37.0 A37.1 A37.8 more
UMLS via Orphanet 75 C0043167 C0043168
Orphanet 60 ORPHA1489

Summaries for Pertussis

MedlinePlus : 44 Whooping cough is an infectious bacterial disease that causes uncontrollable coughing. The name comes from the noise you make when you take a breath after you cough. You may have choking spells or may cough so hard that you vomit. Anyone can get whooping cough, but it is more common in infants and children. It's especially dangerous for infants. The coughing spells can be so bad that it is hard for infants to eat, drink, or breathe. To make a diagnosis, your doctor may do a physical exam, blood tests, chest x-rays, or nose or throat cultures. Before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the U.S. Now most cases are prevented by vaccines. If you have whooping cough, treatment with antibiotics may help if given early. Centers for Disease Control and Prevention

MalaCards based summary : Pertussis, also known as whooping cough, is related to neutrophil migration and bronchiolitis, and has symptoms including fever, pruritus and snoring. An important gene associated with Pertussis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Montelukast and Edetic Acid have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and lung, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A commensal bacterial infectious disease that results in inflammation located in respiratory tract, has material basis in Bordetella pertussis, or has material basis in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

CDC : 3 Pronounced (per-TUS-iss)

Wikipedia : 77 Whooping cough (also known as pertussis or 100-day cough) is a highly contagious bacterial disease.... more...

Related Diseases for Pertussis

Diseases related to Pertussis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 354)
# Related Disease Score Top Affiliating Genes
1 neutrophil migration 30.4 ITGAM ITGB2 MAPK1
2 bronchiolitis 30.3 IL10 IL6 TLR4 TNF
3 sudden infant death syndrome 30.3 IL10 IL1B IL6 TNF
4 pneumonia 30.3 IL10 IL1B IL6 TLR4 TNF
5 legionellosis 30.3 IL1B TLR4 TNF
6 autoimmune disease 30.2 IL10 IL1B IL6 TNF
7 typhoid fever 30.0 IL1B IL6 TLR4 TNF
8 meningitis 30.0 IL10 IL1B IL6 TNF
9 chlamydia 30.0 IL10 IL1B IL6 TLR4 TNF
10 perinatal necrotizing enterocolitis 29.9 IL1B IL6 TLR4 TNF
11 peritonitis 29.9 IL10 IL1B IL6 ITGAM TNF
12 inflammatory bowel disease 29.9 IL10 IL1B IL6 TLR4 TNF
13 laryngitis 29.8 IL1B IL6 TNF
14 lung disease 29.8 IL10 IL1B IL6 TNF
15 transverse myelitis 29.8 IL10 IL6 TNF
16 hematopoietic stem cell transplantation 29.8 IL10 IL6 TNF
17 human immunodeficiency virus type 1 29.8 IL10 IL6 MAPK1 MAPK10 TNF
18 cystitis 29.8 IL6 TLR4 TNF
19 human immunodeficiency virus infectious disease 29.7 IL10 IL6 TNF
20 chorioamnionitis 29.7 IL1B IL6 TLR4 TNF
21 brucellosis 29.7 IL10 IL6 TLR4 TNF
22 kawasaki disease 29.7 IL10 IL6 TNF
23 cytomegalovirus infection 29.7 IL1B IL6 TNF
24 bacterial infectious disease 29.7 IL10 IL1B IL6 ITGAM TLR4 TNF
25 myocarditis 29.6 IL6 ITGB2 TNF
26 bacterial meningitis 29.6 IL10 IL1B IL6 TNF
27 synovitis 29.6 IL1B IL6 TNF
28 contact dermatitis 29.6 IL10 IL1B IL6 TNF
29 q fever 29.5 IL10 IL1B IL6 TLR4 TNF
30 chagas disease 29.5 IL10 IL1B IL6 TLR4 TNF
31 colitis 29.5 IL10 IL1B IL6 TLR4 TNF
32 monocytic leukemia 29.4 IL1B IL6 ITGAM JUN TNF
33 myocardial infarction 29.1 IL10 IL1B IL6 ITGAM TLR4 TNF
34 diphtheria 11.7
35 tetanus 11.1
36 bordetella parapertussis whooping cough 11.1
37 haemophilus influenzae 10.8
38 hepatitis 10.7
39 hepatitis b 10.7
40 influenza 10.5
41 poliomyelitis 10.5
42 measles 10.5
43 cholera 10.4
44 rubella 10.4
45 punctate inner choroidopathy 10.4 IL10 TNF
46 mumps 10.4
47 scarlet fever 10.4
48 prosthetic joint infection 10.4 IL1B TLR4
49 exudative glomerulonephritis 10.4 IL1B TNF
50 campylobacteriosis 10.4 IL1B JUN TLR4

Graphical network of the top 20 diseases related to Pertussis:



Diseases related to Pertussis

Symptoms & Phenotypes for Pertussis

UMLS symptoms related to Pertussis:


fever, pruritus, snoring, coughing

MGI Mouse Phenotypes related to Pertussis:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.44 ADCY10 ADORA1 FOS GNAI1 GNAQ GNAZ
2 hematopoietic system MP:0005397 10.4 FOS GNAI1 GNAQ GNAZ IL10 IL1B
3 behavior/neurological MP:0005386 10.37 ADORA1 FOS GNAI1 GNAQ GNAZ IL10
4 cardiovascular system MP:0005385 10.36 ADCY10 ADORA1 GNAQ IL10 IL1B IL6
5 cellular MP:0005384 10.31 ADCY10 FOS IL10 IL6 ITGAM ITGB2
6 immune system MP:0005387 10.31 FOS GNAI1 GNAQ IL10 IL1B IL6
7 integument MP:0010771 10.29 ADORA1 FOS GNAQ GNAZ IL10 IL1B
8 nervous system MP:0003631 10.28 ADORA1 FOS GNAI1 GNAQ GNAZ IL10
9 mortality/aging MP:0010768 10.27 ADORA1 FOS GNAQ GNAZ IL10 IL1B
10 normal MP:0002873 10.02 ADORA1 FOS GNA15 GNAQ IL10 ITGB2
11 neoplasm MP:0002006 9.98 FOS IL10 IL1B IL6 MAPK1 TLR4
12 no phenotypic analysis MP:0003012 9.91 ADCY10 GNAI1 IL10 JUN MAPK10 OPRM1
13 reproductive system MP:0005389 9.91 ADCY10 FOS GNAZ IL10 IL6 MAPK1
14 respiratory system MP:0005388 9.76 ADORA1 GNAQ IL10 IL6 JUN MAPK1
15 skeleton MP:0005390 9.7 FOS GNAI1 GNAQ IL10 IL1B IL6
16 vision/eye MP:0005391 9.23 FOS IL10 IL6 ITGB2 JUN MAPK1

Drugs & Therapeutics for Pertussis

Drugs for Pertussis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 155)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Montelukast Approved Phase 4 158966-92-8 5281040
2
Edetic Acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 62-33-9, 60-00-4 6049
3
Pentetic acid Approved Phase 4,Phase 3,Phase 2 67-43-6
4
Iron Approved, Experimental Phase 4,Phase 3,Phase 2 7439-89-6, 15438-31-0 23925 27284
5
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
6
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
7
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2 7440-70-2 271
8
BCG vaccine Investigational Phase 4,Phase 2,Not Applicable
9 Vaccines Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
10 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
11 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2
12 Hormones Phase 4,Phase 3
13 Anti-Asthmatic Agents Phase 4
14 Hormone Antagonists Phase 4,Phase 3
15 Respiratory System Agents Phase 4
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
17 Leukotriene Antagonists Phase 4
18 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2
23 Aluminum phosphate Phase 4,Phase 3,Phase 1,Phase 2
24 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
25 Antacids Phase 4,Phase 3,Phase 2
26 Tetanus Antitoxin Phase 4,Phase 3
27 Antidotes Phase 4,Phase 3,Phase 2
28 Antitoxins Phase 4,Phase 3
29 Diphtheria Antitoxin Phase 4,Phase 3
30 Iron Chelating Agents Phase 4,Phase 3,Phase 2
31 Chelating Agents Phase 4,Phase 3,Phase 2
32 Calcium, Dietary Phase 4,Phase 3,Phase 2
33 Anticoagulants Phase 4,Phase 3,Phase 2
34 PENTA Phase 4,Phase 3,Phase 2,Not Applicable
35 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
36 Cyclooxygenase Inhibitors Phase 4,Phase 2
37 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
38 Antipyretics Phase 4,Phase 3
39 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
40 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
42 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
43 Antirheumatic Agents Phase 4,Phase 2
44
Deferiprone Approved Phase 3 30652-11-0 2972
45
Aluminum hydroxide Approved, Investigational Phase 3,Phase 2 21645-51-2
46
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
47
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
48
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
49
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
50
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865

Interventional clinical trials:

(show top 50) (show all 509)
# Name Status NCT ID Phase Drugs
1 Pertussis (Tdap) Vaccination in Pregnancy Unknown status NCT01698346 Phase 4
2 Vaccine Responses in Infants After Acellular Pertussis Vaccination During Pregnancy in Thailand Unknown status NCT02408926 Phase 4
3 Diphtheria, Tetanus, Poliomyelitis -Pertussis-Hib Immunisation in Preterm-born Neonates Unknown status NCT02179996 Phase 4
4 The Safety and Immunogenicity of Acellular Pertussis Vaccine in Bone Marrow Transplant Recipients Unknown status NCT00336115 Phase 4
5 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
6 An Immunogenicity and Safety Study of Tetanus, Diphtheria and Acellular Pertussis Vaccine Booster Unknown status NCT00870350 Phase 4
7 Influence of BCG on TDaP-IPV Vaccination Unknown status NCT02771782 Phase 4
8 Safety, Long Term Immunogenicity and Lot Consistency Study of Liquid Pentavalent Combination Vaccine Unknown status NCT00877357 Phase 4
9 Montelukast for Persistent Cough in Young People and Adults Unknown status NCT01279668 Phase 4 Montelukast;Placebo
10 Pertussis and Meningitis C Concomitant Vaccination in Adolescents Completed NCT02526394 Phase 4 Pertussis containing vaccine
11 A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants Completed NCT02145624 Phase 4 Repevax;Boostrix-IPV
12 Post-marketing Evaluation of Reactions Following Receipt of Recommended Adolescent Pertussis Vaccine Completed NCT00304265 Phase 4
13 Immune Responses in Adults to Revaccination With ADACEL® 10 Years After a Previous Dose Completed NCT00712959 Phase 4
14 Immunogenicity and Safety Study of a Booster Dose (5th) of Diphteria-Tetanus-Pertussis-Polio Vaccine Completed NCT00514059 Phase 4 Boostrix polio
15 Immunogenicity and Safety of Concomitant Administration of RotaTeq™ (V260) and the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus Vaccine (DTP-IPV) in Healthy Japanese Infants (V260-060) Completed NCT01926015 Phase 4
16 Study of Adacel® Vaccine Administered to Persons 10 Years of Age Completed NCT01311557 Phase 4
17 Evaluation of Immunogenicity and Safety of the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus (DPT-IPV) Vaccine Squarekids Co-administered With GSK Biologicals' Human Rotavirus (HRV) Vaccine Rotarix (GSK444563) in Healthy Infants Completed NCT02907216 Phase 4
18 Descriptive, Open-label, Multicenter Study of the Safety of Redosing With ADACEL® Vaccine Completed NCT00347958 Phase 4
19 A Trial to Evaluate the Safety and Immunogenicity of ADACEL® Vaccine in Persons 65 Years of Age and Older Completed NCT00457249 Phase 4
20 Phase IV Interchangeability Study of a Liquid Pentavalent Combination Vaccine Completed NCT00674908 Phase 4
21 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
22 Safety and Immunogenicity in Adults of Revaccination With Adacel® Vaccine 10 Years After a Previous Dose Completed NCT01439165 Phase 4
23 Post-licensure, Modified Double-blind, Multi-center Study Evaluating Safety and Immunogenicity of ADACEL® and BOOSTRIX® Completed NCT00319553 Phase 4
24 Regulatory Post-Marketing Surveillance Study for TETRAXIM™ Completed NCT01437423 Phase 4
25 Tdap Vaccine in Post-Partum Women Completed NCT01711645 Phase 4
26 Post Marketing Surveillance for ADACEL™ in South Korea Completed NCT01137435 Phase 4
27 Immunogenicity of Adacel® and BOOSTRIX® Vaccines in Adolescents Completed NCT01629589 Phase 4
28 Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women Completed NCT02783170 Phase 4
29 A Trial Evaluating a 7-valent Pneumococcal Conjugate Vaccine Given With Diphtheria, Tetanus, and Acellular Pertussis Vaccine (DTaP) in Healthy Japanese Infants. Completed NCT01250756 Phase 4
30 Study of DAPTACEL® Administered as a 5th Dose in 4 to 6-Year-Old Children Previously Immunized With PENTACEL™ Completed NCT00802867 Phase 4
31 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
32 Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination Completed NCT00244673 Phase 4
33 US-licensed Combined Vaccine Against Tetanus & Diphtheria, Given With US-licensed Vaccine Against Meningococcal Disease Completed NCT00282295 Phase 4
34 Concomitant Use of Hepatitis A Vaccine, Inactivated With Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) and Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Given to Healthy Children 15 Months of Age (V251-068) Completed NCT00289913 Phase 4
35 Safety and Immunogenicity Study of a Liquid Pentavalent Combination Vaccine Completed NCT00617812 Phase 4
36 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
37 Study to Assess if Quinvaxem Can be Interchanged With Other Pentavalent Vaccines During Standard Childhood Vaccination Completed NCT01357720 Phase 4
38 Assessment of the Immunogenicity and Safety of PENTAXIM™ in Philippines Completed NCT00254917 Phase 4
39 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women Completed NCT02377349 Phase 4 Saline placebo
40 Immunogenicity and Safety Study of Infanrix Hexa in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery Completed NCT02422264 Phase 4 Prevnar13
41 Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand Completed NCT00255021 Phase 4
42 Tropical Influenza Control Strategies for the Elderly Completed NCT02655874 Phase 4
43 Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination. Completed NCT00610168 Phase 4
44 Immunogenicity and Safety of Booster Dose of BoostrixTM Polio Vaccine in Previously Boosted Adults Completed NCT01323959 Phase 4
45 Immunogenicity and Safety of TETRAXIM™ Given as a Booster Dose at 4 to 6 Years of Age Completed NCT01031303 Phase 4
46 Immunology of Non-specific Effects of Vaccine Completed NCT00168545 Phase 4
47 Evaluation of Boostrix™10 Years After Previous Booster Vaccination Completed NCT01147900 Phase 4
48 Immunogenicity and Safety of BoostrixTM Using a New Syringe in 10 to 15-year Old Adolescents Completed NCT01362322 Phase 4
49 Antibody Persistence to REVAXIS or DT Polio and Immune Response to TETRAVAC-ACELLULAIRE Completed NCT01546909 Phase 4
50 Immunogenicity and Reactogenicity Study of BoostrixTM (dTpa) and Boostrix-IPV (dTpa-IPV) Completed NCT01294605 Phase 4

Search NIH Clinical Center for Pertussis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: bordetella infections

Genetic Tests for Pertussis

Anatomical Context for Pertussis

MalaCards organs/tissues related to Pertussis:

42
Testes, T Cells, Lung, Neutrophil, Colon, B Cells, Monocytes

The Foundational Model of Anatomy Ontology organs/tissues related to Pertussis:

20
Respiratory Tract

Publications for Pertussis

Articles related to Pertussis:

(show top 50) (show all 4660)
# Title Authors Year
1
Acute Bronchitis Caused by Bordetella Pertussis Possibly Co-Infected with Mycoplasma Pneumoniae. ( 30643110 )
2019
2
Persistence of Antibodies against Diphtheria, Tetanus, Pertussis, and Poliovirus Types I, II, and III Following Immunization with DTaP Combined with Inactivated Wild-Type Polio Vaccine (DTaP-wIPV). ( 30381690 )
2019
3
Observational studies of non-specific effects of Diphtheria-Tetanus-Pertussis vaccines in low-income countries: Assessing the potential impact of study characteristics, bias and confounding through meta-regression. ( 30471957 )
2019
4
Neighbourhood influence on the fourth dose of diphtheria-tetanus-pertussis vaccination. ( 30639802 )
2019
5
Post-marketing surveillance to assess the safety and tolerability of a combined diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine (DTaP-IPV) in Korean children. ( 30668217 )
2019
6
Development and Validation of Magnetic Bead Pentaplex Immunoassay for Simultaneous Quantification of murine serum IgG antibodies to Acellular Pertussis, Diphtheria and Tetanus Antigens used in combination vaccines. ( 30690077 )
2019
7
Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study. ( 30785851 )
2019
8
Determinants of delayed or incomplete diphtheria-tetanus-pertussis vaccination in parallel urban and rural birth cohorts of 30,956 infants in Tanzania. ( 30808282 )
2019
9
Completeness and timeliness of diphtheria-tetanus-pertussis, measles-mumps-rubella, and polio vaccines in young children with chronic health conditions: A systematic review. ( 30814030 )
2019
10
Quantitative determination of bioactive proteins in diphtheria tetanus acellular pertussis (DTaP) vaccine by liquid chromatography tandem mass spectrometry. ( 30831450 )
2019
11
Hemolytic uremic syndrome associated with Bordetella pertussis infection in a 2-month-old infant carrying a pathogenic variant in complement factor H. ( 30560448 )
2019
12
Adherence and Concordance of Influenza and Pertussis Vaccination Coverage in Pregnant Women in Spain. ( 30769767 )
2019
13
The Safety of Influenza and Pertussis Vaccination in Pregnancy in a Cohort of Australian Mother-Infant Pairs, 2012-2015: The FluMum Study. ( 30475988 )
2019
14
The MurG glycosyltransferase provides an oligomeric scaffold for the cytoplasmic steps of peptidoglycan biosynthesis in the human pathogen Bordetella pertussis. ( 30874582 )
2019
15
Maternal Vaccination in Argentina: Tdap Vaccine Effectiveness During Pregnancy in Preventing Pertussis in Infants Less Than 2 Months of Age. ( 30877308 )
2019
16
Pertussis: The Identify, Isolate, Inform Tool Applied to a Re-emerging Respiratory Illness. ( 30881535 )
2019
17
Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies. ( 30882004 )
2019
18
Genomic Survey of Bordetella pertussis Diversity, United States, 2000-2013. ( 30882317 )
2019
19
Bordetella pertussis Infection in Infants and Young Children in Shanghai, China, 2016-2017: Clinical Features, Genotype Variations of Antigenic Genes and Macrolides Resistance. ( 30882726 )
2019
20
The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review. ( 30887849 )
2019
21
Genomic epidemiology of erythromycin-resistant Bordetella pertussis in China. ( 30898080 )
2019
22
Challenges and clinical relevance of molecular detection of Bordetella pertussis in South Africa. ( 30898099 )
2019
23
The BvgASR virulence regulon of Bordetella pertussis. ( 30870653 )
2019
24
Immunization with whole cell but not acellular pertussis vaccines primes CD4 TRM cells that sustain protective immunity against nasal colonization with Bordetella pertussis. ( 30866771 )
2019
25
Effects of sex and birth weight on non-specific health services use following whole-cell pertussis vaccination: a self-controlled case series analysis. ( 30829106 )
2019
26
Pertussis (whooping cough). ( 30796107 )
2019
27
The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future. ( 30793754 )
2019
28
Evaluation of the ARIES® Bordetella Assay for Detection and Identification of Bordetella pertussis in Nasopharyngeal Swab Samples. ( 30787143 )
2019
29
Neonatal pertussis diagnosis: low procalcitonin level and high lymphocyte count are able to discriminate pertussis from bacterial and viral infections. ( 30785208 )
2019
30
Pertactin-deficient Bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015. ( 30782265 )
2019
31
The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro. ( 30781809 )
2019
32
Enzyme-linked immunosorbent assay for detecting anti-pertussis toxin antibody in mouse. ( 30775352 )
2019
33
Development and implementation of standardized method for detecting immunogenicity of acellular pertussis vaccines in Korea. ( 30775349 )
2019
34
Immunogenicity and protective potential of Bordetella pertussis biofilm and its associated antigens in a murine model. ( 30770093 )
2019
35
Pertussis Outbreak in Infants and an Immunization Campaign Based on Providing Pertussis Vaccine Doses at 6 Weeks, 10 Weeks, and 14 Weeks. ( 30762709 )
2019
36
Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK. ( 30758857 )
2019
37
Pertussis vaccination status and vaccine acceptance among medical students: multicenter study in Germany and Hungary. ( 30755203 )
2019
38
The prevention of severe pertussis and pertussis deaths in young infants. ( 30736722 )
2019
39
Attributes influencing parental decision-making to receive the Tdap vaccine to reduce the risk of pertussis transmission to their newborn - outcome of a cross-sectional conjoint experiment in Spain and Italy. ( 30735474 )
2019
40
Symptoms Associated With Pertussis Are Insufficient to Rule In or Rule Out the Diagnosis. ( 30732694 )
2019
41
10-Year Review of B Pertussis Related Paediatric Intensive Care Unit Admissions ( 30719900 )
2019
42
Does the economic recession influence the incidence of pertussis in a cosmopolitan European city? ( 30717741 )
2019
43
The use of multiplex PCR for the detection of atypical pathogens in Egyptian children with CAP: a high rate of Bordetella pertussis in early infancy. ( 30713347 )
2019
44
In vitro activity and clinical efficacy of macrolides, cefoperazone-sulbactam and piperacillin/piperacillin-tazobactam against Bordetella pertussis and the clinical manifestations in pertussis patients due to these isolates:A single-center study in Zhejiang Province, China. ( 30710647 )
2019
45
High prevalence of currently circulating Bordetella pertussis isolates not producing vaccine antigen pertactin in Slovenia. ( 30691616 )
2019
46
Genetically detoxified pertussis toxin induces superior antigen specific CD4 T cell responses compared to chemically detoxified pertussis toxin. ( 30689515 )
2019
47
Extending Antenatal Pertussis Immunization to Second Trimester or At-Birth Pertussis Immunization of Premature Infants? ( 30688981 )
2019
48
Extending Antenatal Pertussis Immunization to Second Trimester or At-Birth Pertussis Immunization of Premature Infants?-Reply. ( 30688976 )
2019
49
Osteopathic Manipulative Medicine Use in Pediatric Patients With Pertussis. ( 30688357 )
2019
50
Osteopathic Manipulative Treatment for Pertussis in the 19th and 20th Centuries: A Structured Historical Literature Review. ( 30688349 )
2019

Variations for Pertussis

Expression for Pertussis

Search GEO for disease gene expression data for Pertussis.

Pathways for Pertussis

Pathways related to Pertussis according to GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.19 FOS IL10 IL1B IL6 ITGAM ITGB2
2
Show member pathways
14.04 FOS GNA14 GNA15 GNAI1 GNAQ GNAZ
3
Show member pathways
14.02 FOS GNA14 GNA15 GNAI1 GNAZ IL10
4
Show member pathways
13.89 FOS GNA14 GNA15 GNAI1 GNAZ IL6
5
Show member pathways
13.85 FOS GNA14 GNA15 GNAI1 GNAZ IL10
6
Show member pathways
13.72 ADCY10 GNAI1 GNAQ IL1B IL6 JUN
7
Show member pathways
13.72 FOS GNA14 GNA15 IL10 IL1B IL6
8
Show member pathways
13.59 FOS GNA14 GNA15 GNAI1 GNAZ ITGAM
9
Show member pathways
13.54 FOS IL10 IL1B IL6 ITGAM ITGB2
10
Show member pathways
13.54 FOS GNA14 GNA15 GNAI1 GNAZ IL10
11
Show member pathways
13.48 GNA14 GNA15 GNAI1 GNAQ ITGAM ITGB2
12
Show member pathways
13.46 FOS IL10 IL1B IL6 JUN MAPK1
13
Show member pathways
13.42 FOS GNAI1 IL6 JUN MAPK1 MAPK10
14
Show member pathways
13.41 FOS GNAI1 GNAQ GNAZ IL1B JUN
15
Show member pathways
13.27 ADCY10 FOS GNA14 GNA15 GNAI1 GNAZ
16
Show member pathways
13.26 GNA14 GNA15 GNAI1 GNAQ GNAZ MAPK1
17
Show member pathways
13.25 FOS GNA14 GNA15 GNAI1 GNAZ JUN
18
Show member pathways
13.25 GNA14 GNA15 GNAI1 GNAZ IL6 ITGAM
19
Show member pathways
13.24 FOS GNA14 GNA15 GNAI1 IL6 JUN
20
Show member pathways
13.24 FOS GNA14 GNA15 GNAI1 GNAQ IL10
21
Show member pathways
13.23 ADCY10 FOS GNA15 GNAI1 GNAQ JUN
22
Show member pathways
13.22 FOS GNA14 GNA15 GNAI1 GNAQ GNAZ
23
Show member pathways
13.19 FOS GNA14 GNA15 GNAI1 GNAZ ITGAM
24
Show member pathways
13.17 FOS GNAI1 GNAQ GNAZ IL6 JUN
25
Show member pathways
13.14 FOS GNAI1 GNAQ IL1B IL6 JUN
26
Show member pathways
13.13 ADCY10 FOS ITGAM ITGB2 JUN MAPK1
27
Show member pathways
13.13 FOS GNAI1 GNAQ GNAZ ITGB2 JUN
28
Show member pathways
13.08 FOS GNA14 GNA15 GNAI1 JUN MAPK1
29
Show member pathways
13.06 FOS ITGAM ITGB2 JUN MAPK1 MAPK10
30
Show member pathways
13.06 FOS IL10 IL1B IL6 ITGB2 MAPK1
31
Show member pathways
13.06 GNA14 GNA15 GNAI1 IL6 ITGAM ITGB2
32 13.03 FOS GNAI1 GNAQ IL6 JUN MAPK1
33
Show member pathways
12.95 FOS GNAI1 ITGAM ITGB2 MAPK1
34
Show member pathways
12.95 ADORA1 FOS GNA14 GNA15 GNAI1 GNAZ
35 12.94 FOS IL1B JUN MAPK1 MAPK10 TNF
36
Show member pathways
12.93 FOS JUN MAPK1 MAPK10 TNF
37
Show member pathways
12.92 ADORA1 FOS GNAI1 GNAQ JUN MAPK1
38
Show member pathways
12.91 FOS IL6 JUN MAPK1 TNF
39
Show member pathways
12.91 GNAI1 GNAQ ITGAM ITGB2 MAPK1 MAPK10
40
Show member pathways
12.89 IL1B IL6 MAPK10 TLR4 TNF
41
Show member pathways
12.88 FOS GNAI1 GNAQ GNAZ IL1B JUN
42
Show member pathways
12.86 FOS IL1B JUN MAPK1 MAPK10 TNF
43
Show member pathways
12.84 FOS GNA15 IL10 JUN MAPK1 MAPK10
44
Show member pathways
12.83 FOS GNAQ IL1B JUN MAPK1 MAPK10
45
Show member pathways
12.82 FOS IL6 JUN MAPK1 MAPK10
46
Show member pathways
12.81 GNA14 GNA15 GNAI1 GNAZ MAPK1
47
Show member pathways
12.79 FOS IL10 IL1B IL6 MAPK1 TNF
48
Show member pathways
12.79 FOS IL1B IL6 JUN MAPK1 MAPK10
49
Show member pathways
12.78 FOS IL10 IL1B IL6 JUN MAPK1
50
Show member pathways
12.77 GNA14 GNA15 GNAI1 GNAZ JUN MAPK1

GO Terms for Pertussis

Cellular components related to Pertussis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.35 GNAI1 ITGAM ITGB2 OPRM1 TNF
2 transcription factor AP-1 complex GO:0035976 9.32 FOS JUN
3 integrin alphaM-beta2 complex GO:0034688 9.16 ITGAM ITGB2
4 heterotrimeric G-protein complex GO:0005834 9.02 GNA14 GNA15 GNAI1 GNAQ GNAZ
5 plasma membrane GO:0005886 10.1 ADCY10 ADORA1 GNA14 GNA15 GNAI1 GNAQ

Biological processes related to Pertussis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.98 FOS IL10 ITGB2 JUN SERPING1
2 Fc-epsilon receptor signaling pathway GO:0038095 9.96 FOS JUN MAPK1 MAPK10
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.96 IL10 IL1B IL6 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.96 IL10 IL1B IL6 TLR4 TNF
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.94 JUN OPRM1 TLR4 TNF
6 positive regulation of JNK cascade GO:0046330 9.92 IL1B TLR4 TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 IL1B IL6 ITGB2 TLR4 TNF
8 apoptotic signaling pathway GO:0097190 9.9 ADORA1 TLR4 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 IL6 JUN TNF
10 activation of MAPK activity GO:0000187 9.89 IL1B MAPK1 MAPK10 TLR4 TNF
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 IL1B TLR4 TNF
12 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.88 IL10 JUN TNF
13 positive regulation of interferon-gamma production GO:0032729 9.87 IL1B TLR4 TNF
14 cellular response to organic substance GO:0071310 9.87 IL1B MAPK1 MAPK10
15 cellular response to cadmium ion GO:0071276 9.85 FOS JUN MAPK1
16 cellular response to reactive oxygen species GO:0034614 9.85 FOS JUN MAPK1
17 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.85 ADORA1 GNAI1 GNAZ OPRM1
18 platelet activation GO:0030168 9.85 GNA14 GNA15 GNAQ IL6 MAPK1
19 regulation of sensory perception of pain GO:0051930 9.84 ADORA1 IL10 OPRM1
20 positive regulation of interleukin-6 production GO:0032755 9.84 IL1B IL6 TLR4 TNF
21 negative regulation of interleukin-6 production GO:0032715 9.83 IL10 TLR4 TNF
22 positive regulation of interleukin-8 production GO:0032757 9.82 IL1B TLR4 TNF
23 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.82 FOS IL10 JUN
24 negative regulation of neurogenesis GO:0050768 9.81 IL1B IL6 TNF
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B ITGB2 TLR4 TNF
26 regulation of DNA-binding transcription factor activity GO:0051090 9.8 FOS JUN MAPK1
27 positive regulation of chemokine production GO:0032722 9.79 IL6 TLR4 TNF
28 negative regulation of lipid catabolic process GO:0050995 9.79 ADORA1 IL1B TNF
29 positive regulation of glial cell proliferation GO:0060252 9.78 IL1B IL6 TNF
30 toll-like receptor 4 signaling pathway GO:0034142 9.77 ITGAM ITGB2 TLR4
31 inflammatory response GO:0006954 9.76 ADORA1 FOS IL10 IL1B IL6 ITGB2
32 response to glucocorticoid GO:0051384 9.75 IL10 IL6 TNF
33 amyloid-beta clearance GO:0097242 9.74 ITGAM ITGB2
34 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.74 ITGAM ITGB2
35 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TLR4 TNF
36 negative regulation of lipid storage GO:0010888 9.74 IL6 TNF
37 negative regulation of synaptic transmission GO:0050805 9.74 GNAI1 IL1B
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 IL10 IL1B TNF
39 positive regulation of microglial cell activation GO:1903980 9.73 ITGAM ITGB2
40 endothelial cell apoptotic process GO:0072577 9.73 IL10 TNF
41 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
42 positive regulation of neuron death GO:1901216 9.73 ADORA1 FOS ITGAM ITGB2
43 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.72 GNA14 GNA15
44 positive regulation of lipid catabolic process GO:0050996 9.72 ADORA1 IL1B
45 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL10 TLR4
46 regulation of establishment of endothelial barrier GO:1903140 9.71 IL1B TNF
47 negative regulation of cytokine secretion involved in immune response GO:0002740 9.71 IL10 TNF
48 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 IL1B MAPK1 TLR4 TNF
49 positive regulation of fever generation GO:0031622 9.7 IL1B TNF
50 cellular extravasation GO:0045123 9.69 ITGB2 TNF

Molecular functions related to Pertussis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.85 GNA14 GNA15 GNAI1 GNAQ GNAZ
2 cytokine activity GO:0005125 9.8 IL10 IL1B IL6 TNF
3 protein heterodimerization activity GO:0046982 9.8 ADORA1 FOS ITGAM ITGB2 JUN TLR4
4 GTPase activity GO:0003924 9.77 GNA14 GNA15 GNAI1 GNAQ GNAZ
5 heat shock protein binding GO:0031072 9.65 ADORA1 ITGAM ITGB2
6 G protein-coupled receptor binding GO:0001664 9.63 ADORA1 GNA14 GNA15 GNAI1 GNAQ GNAZ
7 complement component C3b binding GO:0001851 9.43 ITGAM ITGB2
8 G protein-coupled serotonin receptor binding GO:0031821 9.4 GNAI1 GNAZ
9 guanyl nucleotide binding GO:0019001 9.35 GNA14 GNA15 GNAI1 GNAQ GNAZ
10 G-protein beta/gamma-subunit complex binding GO:0031683 9.1 ADORA1 GNA14 GNA15 GNAI1 GNAQ GNAZ
11 protein binding GO:0005515 10.21 ADORA1 FOS GNA14 GNAI1 GNAQ GNAZ

Sources for Pertussis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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