MCID: PTR001
MIFTS: 29

Petrositis

Categories: Bone diseases, Ear diseases

Aliases & Classifications for Petrositis

MalaCards integrated aliases for Petrositis:

Name: Petrositis 12 43 15 71 32
Chronic Petrositis 12 71
Acute Petrositis 12 71
Inflammation of Petrous Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10755
MeSH 43 D059270
UMLS 71 C0155448 C0155449 C0155450

Summaries for Petrositis

Disease Ontology : 12 An osteomyelitis that has material basis in infection located in petrous part of temporal bone.

MalaCards based summary : Petrositis, also known as chronic petrositis, is related to adenoma and pituitary adenoma. An important gene associated with Petrositis is LAPTM4A (Lysosomal Protein Transmembrane 4 Alpha), and among its related pathways/superpathways is MECP2 and Associated Rett Syndrome. Affiliated tissues include petrous part of temporal bone, bone and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Petrositis

Diseases related to Petrositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 adenoma 10.7
2 pituitary adenoma 10.6
3 meningioma, radiation-induced 10.5
4 meningioma, familial 10.5
5 spinal meningioma 10.5
6 secretory meningioma 10.5
7 lymphoplasmacyte-rich meningioma 10.5
8 trigeminal neuralgia 10.5
9 conn's syndrome 10.5
10 facial paralysis 10.5
11 neurilemmoma 10.5
12 acth-secreting pituitary adenoma 10.4
13 otitis media 10.4
14 pituitary adenoma 4, acth-secreting 10.4
15 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
16 mastoiditis 10.4
17 petroclival meningioma 10.4
18 cholesteatoma of middle ear 10.4
19 pituitary-dependent cushing's disease 10.3
20 headache 10.3
21 rare surgical neurologic disease 10.3
22 thrombosis 10.3
23 exophthalmos 10.3
24 pituitary tumors 10.3
25 arteriovenous malformation 10.2
26 acromegaly 10.2
27 acth-dependent cushing syndrome 10.2
28 bursitis 10.2 LAPTM4A CRP
29 enthesopathy 10.2 LAPTM4A CRP
30 polyradiculopathy 10.2 LAPTM4A CRP
31 hemifacial spasm, familial 10.1
32 superior semicircular canal dehiscence 10.1
33 xerophthalmia 10.1
34 osteomyelitis 10.1
35 abducens nerve disease 10.1
36 hydrocephalus 10.1
37 acoustic neuroma 10.1
38 keratoconjunctivitis sicca 10.1
39 cavernous sinus thrombosis 10.1
40 cranial nerve palsy 10.1
41 petrous apex meningioma 10.1
42 meningitis 10.1
43 hemifacial spasm 10.1
44 hypoxia 10.1
45 abducens palsy 10.1
46 epidermoid cysts 10.1
47 thrombophilia due to thrombin defect 10.1
48 hyperprolactinemia 10.1
49 labyrinthitis 10.1
50 brain stem infarction 10.1

Graphical network of the top 20 diseases related to Petrositis:



Diseases related to Petrositis

Symptoms & Phenotypes for Petrositis

GenomeRNAi Phenotypes related to Petrositis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.68 CRP LAPTM4A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.68 CRP MGP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.68 LAPTM4A MGP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.68 MGP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.68 CRP LAPTM4A MGP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.68 CRP MGP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.68 MGP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.68 LAPTM4A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.68 LAPTM4A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.68 CRP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.68 LAPTM4A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.68 MGP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.68 CRP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.68 MGP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.68 MGP
16 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.68 MGP
17 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.68 MGP

Drugs & Therapeutics for Petrositis

Search Clinical Trials , NIH Clinical Center for Petrositis

Cochrane evidence based reviews: petrositis

Genetic Tests for Petrositis

Anatomical Context for Petrositis

The Foundational Model of Anatomy Ontology organs/tissues related to Petrositis:

19
Petrous Part Of Temporal Bone

MalaCards organs/tissues related to Petrositis:

40
Bone, Pituitary, Brain, Pancreas, Prostate

Publications for Petrositis

Articles related to Petrositis:

(show top 50) (show all 114)
# Title Authors PMID Year
1
Gradenigo's syndrome with abscess of the petrous apex in pediatric patients: what is the best treatment? 61
31432224 2019
2
Acute Otitis Media and Associated Complications in United States Emergency Departments. 61
30113560 2018
3
Recurrent petrositis due to nasopharyngeal carcinoma in an adult patient: Gradenigo's syndrome. 61
30197368 2018
4
Identification and return of a skull from Tasmania in the Berlin anatomical collection. 61
29319715 2018
5
Gradenigo's Syndrome and Labyrinthitis: Conservative versus Surgical Treatment. 61
30155332 2018
6
Gradenigo's Syndrome in a Patient with Chronic Suppurative Otitis Media, Petrous Apicitis, and Meningitis. 61
28955030 2017
7
Acute Otitis Media-Induced Gradenigo Syndrome, a Dramatic Response to Intravenous Antibiotic. 61
28589111 2017
8
Pediatric Acute Otitis Media in the Era of Pneumococcal Vaccination. 61
28349737 2017
9
[Diagnosis and treatment of the complications of otitis media in adults. Case series and literature review]. 61
26738650 2016
10
[Apical petrositis, osteomyelitis of the base of the skull bones and of the first cervical vertebra in a 5 year-old children following chicken pox]. 61
26977573 2016
11
[Gradenigo syndrome and petrositis in a child]. 61
25524289 2015
12
[Petrositis complicated by cavernous sinus thrombosis and meningitis]. 61
26525321 2015
13
Petrositis With Bilateral Abducens Nerve Palsies complicated by Acute Otitis Media. 61
24587883 2014
14
Unusual presentation of acute otomastoiditis with petrositis. 61
23551910 2013
15
Earache. 61
23601480 2013
16
Subacute tuberculous otitis media complicated by petrositis and meningitis. 61
24006831 2012
17
[Petrositis due to acute otitis media: a case report and literature review]. 61
22242473 2011
18
Ophthalmic complications of otitis media in children. 61
21777800 2011
19
Unusual fatal petrositis presenting as myofascial pain and dysfunction of the temporal muscle. 61
21519562 2011
20
Complications of acute otitis media in children: case reports and review of literature. 61
21409946 2010
21
[Gradenigo's syndrome: a case-report]. 61
20544125 2010
22
Pediatric otogenic intracranial abscesses. 61
20172394 2010
23
Imaging of the petrous apex: a pictorial review. 61
18208855 2008
24
[Isolated apical petrositis: an atypical case of Gradenigo's syndrome]. 61
16625371 2007
25
[MRI of the temporal bone]. 61
17124479 2006
26
Circumferential petrosectomy for petrous apicitis and cranial base osteomyelitis. 61
17006351 2006
27
Primary tuberculous petrositis. 61
16353409 2005
28
Petrositis in Ramsay Hunt syndrome with multiple cranial neuropathies. 61
16286554 2005
29
Two stage management of petrositis with associated mycotic aneurysm of the intrapetrous carotid artery. 61
15992478 2005
30
[Acute otitis media and its life-threatening complications]. 61
15295926 2004
31
Apical petrositis. 61
15266869 2004
32
Pediatric neurotology. 61
14992462 2003
33
Petrositis and cerebellar abscess complicating chronic otitis media. 61
14629535 2003
34
Streptococcus acidominimus infection in a child causing Gradenigo syndrome. 61
12791460 2003
35
Gradenigo syndrome: a case-report. 61
14750230 2003
36
[The apical petrositis. An unusually pronounced impacted bony tip]. 61
14618968 2003
37
Superior orbital 'petrositis' and late ischaemic monocular blindness induced by intense UV radiation exposure. 61
12091588 2002
38
Recurrent temporal petrositis. 61
11276339 2001
39
Unusual lesions of the cerebellopontine angle: a segmental approach. 61
11259705 2001
40
Acute mastoiditis--the antibiotic era: a multicenter study. 61
11165635 2001
41
[Results and extraordinary complications of surgery for exostoses of the external auditory canal]. 61
10663060 2000
42
Management of abducens palsy in patients with petrositis. 61
10527283 1999
43
[Carcinoma of the nasopharynx, radiotherapy, otitis, labyrinthitis, inflammation of the petrous bone, meningitis]. 61
10230088 1999
44
Intratemporal complications of acute otitis media in infants and children. 61
9807067 1998
45
[Gradenigo syndrome and cavernous sinus thrombosis in fusobacterial acute otitis media]. 61
9418358 1997
46
Middle ear infection and sixth nerve palsy. 61
8949301 1996
47
Gradenigo's syndrome: CT and MRI findings. 61
8781114 1996
48
MRI of petrositis in chronic granulomatous disease. 61
7885794 1994
49
Histopathologic and ultrastructural changes in the temporal bones of HIV-infected human adults. 61
1609848 1992
50
[A case of acute suppurative otitis media with petrositis]. 61
2360316 1990

Variations for Petrositis

Expression for Petrositis

Search GEO for disease gene expression data for Petrositis.

Pathways for Petrositis

Pathways related to Petrositis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.42 SST SP3

GO Terms for Petrositis

Biological processes related to Petrositis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 8.62 SP3 MGP

Sources for Petrositis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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