Petrous Apex Meningioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Petrous Apex Meningioma

MalaCards integrated aliases for Petrous Apex Meningioma:

Name: Petrous Apex Meningioma ¹¹ ¹⁴ ⁷¹

Meningioma of the Petrous Ridge ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:7482

NCIt ⁴⁹ C5271

UMLS ⁷¹ C1335396

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Summaries for Petrous Apex Meningioma

MalaCards based summary: Petrous Apex Meningioma, also known as meningioma of the petrous ridge, is related to meningioma, familial and neurofibromatosis, and has symptoms including headache and seizures. An important gene associated with Petrous Apex Meningioma is KANTR (KANTR Integral Membrane Protein), and among its related pathways/superpathways are Cytoskeletal Signaling and Regulation of actin cytoskeleton. The drug Kava has been mentioned in the context of this disorder. Related phenotypes are homeostasis/metabolism and digestive/alimentary

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Related Diseases for Petrous Apex Meningioma

Diseases related to Petrous Apex Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)

#	Related Disease	Score	Top Affiliating Genes
1	meningioma, familial	30.1	TCHP RDX NF2 MSN EZR EPB41
2	neurofibromatosis	29.9	RDX NF2 MSN EZR
3	neurilemmoma	29.9	RDX NF2 MSN EZR
4	acoustic neuroma	29.5	RDX PXN NF2 MSN EZR
5	neurofibromatosis, type ii	29.3	TCHP RDX NF2 MSN EZR EPB41
6	trigeminal neuralgia	10.5
7	foramen magnum meningioma	10.3	NF2 KANTR
8	cerebellopontine angle meningioma	10.3	NF2 EPB41L2
9	glossopharyngeal nerve disease	10.3	NF2 KANTR
10	cerebellopontine angle tumor	10.3	NF2 KANTR
11	suprasellar meningioma	10.2	NTSR1 NF2
12	anterior cranial fossa meningioma	10.2	NF2 EPB41
13	transitional meningioma	10.2	NF2 EPB41
14	tuberculum sellae meningioma	10.2	NF2 EPB41L2 EPB41
15	sella turcica neoplasm	10.2	NF2 EPB41L2 EPB41
16	schwannoma of twelfth cranial nerve	10.2	NTSR1 NF2
17	hypoglossal nerve disease	10.2	NTSR1 NF2
18	optic nerve sheath meningioma	10.2	NF2 MSN
19	spinal canal and spinal cord meningioma	10.2	NF2 EPB41
20	spinal meningioma	10.1	NF2 EPB41
21	neurilemmoma of the fifth cranial nerve	10.1	TFF3 NTSR1 NF2
22	trigeminal nerve neoplasm	10.1	TFF3 NTSR1 NF2
23	tremor, hereditary essential, 2	10.1	TFF3 NTSR1
24	supratentorial meningioma	10.1	NF2 AQP4
25	abducens palsy	10.0	KANTR AQP4
26	cranial nerve palsy	10.0	NF2 KANTR AQP4
27	facial nerve disease	10.0	NF2 KANTR AQP4
28	facial paralysis	10.0	NF2 KANTR AQP4
29	salpingitis isthmica nodosa	10.0	NF2 ADA
30	acute flaccid myelitis	10.0	NTSR1 AQP4
31	subacute delirium	9.9	AQP4 ADA
32	plexiform neurofibroma	9.9	NF2 DHH
33	deafness, autosomal recessive 24	9.9	RDX MSN EZR
34	immunodeficiency 50	9.9	RDX MSN EZR
35	leukocyte adhesion deficiency, type iii	9.9	RDX MSN EZR
36	kindler syndrome	9.9	RDX MSN EZR
37	sarcoid meningitis	9.9	NF2 AQP4 ADA
38	obstructive hydrocephalus	9.8	NF2 AQP4
39	bone squamous cell carcinoma	9.8	SERPINB5 ENG

Graphical network of the top 20 diseases related to Petrous Apex Meningioma:

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Symptoms & Phenotypes for Petrous Apex Meningioma

UMLS symptoms related to Petrous Apex Meningioma:

headache; seizures

MGI Mouse Phenotypes related to Petrous Apex Meningioma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.8	ADA AQP4 DHH ENG EPB41 MSN
2	digestive/alimentary	MP:0005381	9.32	ADA AQP4 DHH ENG EZR NF2

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Drugs & Therapeutics for Petrous Apex Meningioma

Drugs for Petrous Apex Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Kava	Approved, Investigational, Nutraceutical			9000-38-8

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	The Petro-trigeminal Line: a Simple Radiological Marker for the Diagnosis of Cephaloceles of the Petrous Apex on MRI	Recruiting	NCT05639491

Search NIH Clinical Center for Petrous Apex Meningioma

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Genetic Tests for Petrous Apex Meningioma

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Anatomical Context for Petrous Apex Meningioma

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Publications for Petrous Apex Meningioma

Articles related to Petrous Apex Meningioma:

(show all 20)

#	Title	Authors	PMID	Year
1	Anterior Transpetrosal-Transtentorial Approach for Removal of a Large Petrous Apex Meningioma: 2-Dimensional Operative Video. ⁶²	Lasica N...Papic V	36228932	2022
2	Anterior Petrosal Approach to Petrous Apex Meningioma: Climbing the Rock-Two-Dimensional Operative Video. ⁶²	da Silva CE...Coutinho Abrao AA	35314406	2022
3	Microsurgery versus stereotactic radiosurgery for small petroclival meningiomas presenting with intractable trigeminal neuropathy: A historical cohort study. ⁶²	Hegazy A...A Ali MF	35864615	2022
4	Drilling off the Petrosal Apex and Opening the Upper Wall of Meckel's Cave Are the Key Elements of Good Outcomes in the Treatment of Trigeminal Neuralgia Secondary to Petrous Apex Meningioma. ⁶²	Bai J...Xiao X	35286800	2022
5	Combined translabyrinthine, anterior petrosal approach for resection of collision vestibular schwannoma and petrous apex meningioma in neurofibromatosis type 2, with auditory brainstem implant placement. ⁶²	Khan UA...Schwartz MS	36285231	2021
6	Anterior Petrosal Approach for the Resection of a Petrous Apex Meningioma with Tentorial Infiltration. ⁶²	Mendez-Rosito D	31143603	2019
7	Petrous Apex Meningioma with Extension into Meckel's Cave: Resection using a Retrosigmoid Intradural Suprameatal Approach. ⁶²	Munich SA...Morcos JJ	31143601	2019
8	Role of surgery for small petrous apex meningiomas causing refractory trigeminal neuropathy in the minimally invasive era. ⁶²	Hegazy A...Biswas A	27625241	2016
9	Extended Suboccipital Retrosigmoid Surgical Approach Is Effective for Resection of Petrous Apex Meningioma. ⁶²	Cui H...Wang Y	27300453	2016
10	Anatomy of the superior petrosal veins and their exposure and management during petrous apex meningioma surgery using the lateral suboccipital retrosigmoid approach. ⁶²	Matsushima T...Matsushima K	24781190	2014
11	Retrosigmoid approach for resection of petrous apex meningioma. ⁶²	de Souza DG...Prevedello DM	24380515	2014
12	The suprameatal dural flap for superior petrosal vein protection during the retrosigmoid intradural suprameatal approach. ⁶²	Mortini P...Franzin A	23673670	2014
13	[Endoscopically assisted removal of posterior fossa meningioma combined with microvascular decompression of trigeminal nerve root (early experience)]. ⁶²	Shimanskii VN...Semenov VK	22379855	2011
14	Microsurgical removal of a petrous apex meningioma after stereotactic radiation: technical case report. ⁶²	Samii M...Tatagiba MS	11440447	2001
15	Removal of petrous apex meningioma and microvascular decompression for trigeminal neuralgia through the anterior petrosal approach. Case report. ⁶²	Kuroki A...Saito S	10396120	1999
16	[The contribution of "time-of-flight" MRI-angiography in the study of neurovascular interactions (hemifacial spasm and trigeminal neuralgia)]. ⁶²	Holley P...Manelfe C	9091607	1996
17	Combined and three-dimensional rendered multimodal data for planning cranial base surgery: a prospective evaluation. ⁶²	Gandhe AJ...Strong AJ	7800138	1994
18	Facial nerve preservation in patients with large acoustic neuromas treated by a combined middle fossa transtentorial translabyrinthine approach. ⁶²	Tator CH...Nedzelski JM	6979613	1982
19	The superficial recurrent ophthalmic artery: meningeal supply to petrous ridge meningiomas. ⁶²	Shields CB...Rice JF	450239	1979
20	Surgical management of petrous apex meningioma. ⁶²	Goin DW	423660	1979

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Genes for Petrous Apex Meningioma

Genes related to Petrous Apex Meningioma (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KANTR	KANTR Integral Membrane Protein	Protein Coding	5.82	DISEASES inferred ¹⁴
2	EPB41L2	Erythrocyte Membrane Protein Band 4.1 Like 2	Protein Coding	5.13	DISEASES inferred ¹⁴
3	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	4.96	DISEASES inferred ¹⁴
4	ERBIN	Erbb2 Interacting Protein	Protein Coding	4.41	DISEASES inferred ¹⁴
5	EPB41	Erythrocyte Membrane Protein Band 4.1	Protein Coding	4.11	DISEASES inferred ¹⁴
6	DHH	Desert Hedgehog Signaling Molecule	Protein Coding	3.96	DISEASES inferred ¹⁴
7	PDGFC	Platelet Derived Growth Factor C	Protein Coding	3.91	DISEASES inferred ¹⁴
8	NTSR1	Neurotensin Receptor 1	Protein Coding	3.77	DISEASES inferred ¹⁴
9	TFF3	Trefoil Factor 3	Protein Coding	3.76	DISEASES inferred ¹⁴
10	TREM1	Triggering Receptor Expressed On Myeloid Cells 1	Protein Coding	3.76	DISEASES inferred ¹⁴
11	SERPINB5	Serpin Family B Member 5	Protein Coding	3.76	DISEASES inferred ¹⁴
12	RDX	Radixin	Protein Coding	3.67	DISEASES inferred ¹⁴
13	MSN	Moesin	Protein Coding	3.59	DISEASES inferred ¹⁴
14	PXN	Paxillin	Protein Coding	3.37	DISEASES inferred ¹⁴
15	ADA	Adenosine Deaminase	Protein Coding	3.32	DISEASES inferred ¹⁴
16	EZR	Ezrin	Protein Coding	3.25	DISEASES inferred ¹⁴
17	AQP4	Aquaporin 4	Protein Coding	2.91	DISEASES inferred ¹⁴
18	ENG	Endoglin	Protein Coding	2.9	DISEASES inferred ¹⁴
19	TCHP	Trichoplein Keratin Filament Binding	Protein Coding	2.88	DISEASES inferred ¹⁴

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Variations for Petrous Apex Meningioma

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Expression for Petrous Apex Meningioma

Search GEO for disease gene expression data for Petrous Apex Meningioma.

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Pathways for Petrous Apex Meningioma

Pathways related to Petrous Apex Meningioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ³	11.84	RDX PXN NF2 MSN EZR
2	Regulation of actin cytoskeleton ⁷⁴	11.64	RDX PXN MSN EZR
3	PtdIns(4,5)P2 in cytokinesis pathway ⁷⁴	9.84	RDX MSN EZR

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GO Terms for Petrous Apex Meningioma

Cellular components related to Petrous Apex Meningioma according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	10.63	ADA AQP4 DHH ENG EPB41 EPB41L2
2	plasma membrane	GO:0005887	10.63	AQP4 NTSR1
3	membrane	GO:0016021	10.62	TREM1 NTSR1 KANTR EPB41 ENG AQP4
4	membrane	GO:0016020	10.62	TREM1 TCHP RDX PDGFC NTSR1 NF2
5	cytoskeleton	GO:0005856	10.15	TCHP RDX PXN NF2 MSN EZR
6	focal adhesion	GO:0005925	10.1	ENG EPB41L2 EZR MSN PXN RDX
7	adherens junction	GO:0005912	10.06	RDX NF2 MSN EZR
8	cell cortex	GO:0005938	9.98	PXN EZR EPB41L2 EPB41
9	basolateral plasma membrane	GO:0016323	9.96	MSN EZR ERBIN EPB41 AQP4
10	microvillus	GO:0005902	9.95	EZR MSN RDX
11	uropod	GO:0001931	9.8	MSN EZR
12	apical part of cell	GO:0045177	9.76	RDX NF2 MSN EZR
13	filopodium	GO:0030175	9.5	RDX NF2 MSN EZR
14	cell periphery	GO:0071944	9.17	RDX NF2 MSN EZR

Biological processes related to Petrous Apex Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of cell shape	GO:0008360	10.03	RDX MSN EZR EPB41
2	positive regulation of protein catabolic process	GO:0045732	9.95	RDX MSN EZR
3	establishment of endothelial barrier	GO:0061028	9.73	RDX MSN EZR
4	regulation of cell size	GO:0008361	9.72	EZR MSN RDX
5	positive regulation of protein localization to cell cortex	GO:1904778	9.71	EPB41L2 EPB41
6	membrane to membrane docking	GO:0022614	9.67	MSN EZR
7	gland morphogenesis	GO:0022612	9.63	MSN EZR
8	positive regulation of protein localization to early endosome	GO:1902966	9.63	RDX MSN EZR
9	positive regulation of early endosome to late endosome transport	GO:2000643	9.43	RDX MSN EZR
10	regulation of organelle assembly	GO:1902115	9.1	RDX MSN EZR

Molecular functions related to Petrous Apex Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	actin binding	GO:0003779	9.73	RDX NF2 MSN EZR EPB41L2 EPB41
2	cell adhesion molecule binding	GO:0050839	9.63	RDX MSN EZR
3	cytoskeletal protein binding	GO:0008092	9.1	RDX NF2 MSN EZR EPB41L2 EPB41

Sources

Sources for Petrous Apex Meningioma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PTR003 MIFTS: 26	Petrous Apex Meningioma Categories: Cancer diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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