MCID: PTR003
MIFTS: 26

Petrous Apex Meningioma

Categories: Cancer diseases, Neuronal diseases
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Aliases & Classifications for Petrous Apex Meningioma

MalaCards integrated aliases for Petrous Apex Meningioma:

Name: Petrous Apex Meningioma 11 14 71
Meningioma of the Petrous Ridge 11

Classifications:



External Ids:

Disease Ontology 11 DOID:7482
NCIt 49 C5271
UMLS 71 C1335396

Summaries for Petrous Apex Meningioma

MalaCards based summary: Petrous Apex Meningioma, also known as meningioma of the petrous ridge, is related to meningioma, familial and neurofibromatosis, and has symptoms including headache and seizures. An important gene associated with Petrous Apex Meningioma is KANTR (KANTR Integral Membrane Protein), and among its related pathways/superpathways are Cytoskeletal Signaling and Regulation of actin cytoskeleton. The drug Kava has been mentioned in the context of this disorder. Related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Petrous Apex Meningioma

Diseases related to Petrous Apex Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 30.1 TCHP RDX NF2 MSN EZR EPB41
2 neurofibromatosis 29.9 RDX NF2 MSN EZR
3 neurilemmoma 29.9 RDX NF2 MSN EZR
4 acoustic neuroma 29.5 RDX PXN NF2 MSN EZR
5 neurofibromatosis, type ii 29.3 TCHP RDX NF2 MSN EZR EPB41
6 trigeminal neuralgia 10.5
7 foramen magnum meningioma 10.3 NF2 KANTR
8 cerebellopontine angle meningioma 10.3 NF2 EPB41L2
9 glossopharyngeal nerve disease 10.3 NF2 KANTR
10 cerebellopontine angle tumor 10.3 NF2 KANTR
11 suprasellar meningioma 10.2 NTSR1 NF2
12 anterior cranial fossa meningioma 10.2 NF2 EPB41
13 transitional meningioma 10.2 NF2 EPB41
14 tuberculum sellae meningioma 10.2 NF2 EPB41L2 EPB41
15 sella turcica neoplasm 10.2 NF2 EPB41L2 EPB41
16 schwannoma of twelfth cranial nerve 10.2 NTSR1 NF2
17 hypoglossal nerve disease 10.2 NTSR1 NF2
18 optic nerve sheath meningioma 10.2 NF2 MSN
19 spinal canal and spinal cord meningioma 10.2 NF2 EPB41
20 spinal meningioma 10.1 NF2 EPB41
21 neurilemmoma of the fifth cranial nerve 10.1 TFF3 NTSR1 NF2
22 trigeminal nerve neoplasm 10.1 TFF3 NTSR1 NF2
23 tremor, hereditary essential, 2 10.1 TFF3 NTSR1
24 supratentorial meningioma 10.1 NF2 AQP4
25 abducens palsy 10.0 KANTR AQP4
26 cranial nerve palsy 10.0 NF2 KANTR AQP4
27 facial nerve disease 10.0 NF2 KANTR AQP4
28 facial paralysis 10.0 NF2 KANTR AQP4
29 salpingitis isthmica nodosa 10.0 NF2 ADA
30 acute flaccid myelitis 10.0 NTSR1 AQP4
31 subacute delirium 9.9 AQP4 ADA
32 plexiform neurofibroma 9.9 NF2 DHH
33 deafness, autosomal recessive 24 9.9 RDX MSN EZR
34 immunodeficiency 50 9.9 RDX MSN EZR
35 leukocyte adhesion deficiency, type iii 9.9 RDX MSN EZR
36 kindler syndrome 9.9 RDX MSN EZR
37 sarcoid meningitis 9.9 NF2 AQP4 ADA
38 obstructive hydrocephalus 9.8 NF2 AQP4
39 bone squamous cell carcinoma 9.8 SERPINB5 ENG

Graphical network of the top 20 diseases related to Petrous Apex Meningioma:



Diseases related to Petrous Apex Meningioma

Symptoms & Phenotypes for Petrous Apex Meningioma

UMLS symptoms related to Petrous Apex Meningioma:


headache; seizures

MGI Mouse Phenotypes related to Petrous Apex Meningioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 ADA AQP4 DHH ENG EPB41 MSN
2 digestive/alimentary MP:0005381 9.32 ADA AQP4 DHH ENG EZR NF2

Drugs & Therapeutics for Petrous Apex Meningioma

Drugs for Petrous Apex Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Kava Approved, Investigational, Nutraceutical 9000-38-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Petro-trigeminal Line: a Simple Radiological Marker for the Diagnosis of Cephaloceles of the Petrous Apex on MRI Recruiting NCT05639491

Search NIH Clinical Center for Petrous Apex Meningioma

Genetic Tests for Petrous Apex Meningioma

Anatomical Context for Petrous Apex Meningioma

Publications for Petrous Apex Meningioma

Articles related to Petrous Apex Meningioma:

(show all 20)
# Title Authors PMID Year
1
Anterior Transpetrosal-Transtentorial Approach for Removal of a Large Petrous Apex Meningioma: 2-Dimensional Operative Video. 62
36228932 2022
2
Anterior Petrosal Approach to Petrous Apex Meningioma: Climbing the Rock-Two-Dimensional Operative Video. 62
35314406 2022
3
Microsurgery versus stereotactic radiosurgery for small petroclival meningiomas presenting with intractable trigeminal neuropathy: A historical cohort study. 62
35864615 2022
4
Drilling off the Petrosal Apex and Opening the Upper Wall of Meckel's Cave Are the Key Elements of Good Outcomes in the Treatment of Trigeminal Neuralgia Secondary to Petrous Apex Meningioma. 62
35286800 2022
5
Combined translabyrinthine, anterior petrosal approach for resection of collision vestibular schwannoma and petrous apex meningioma in neurofibromatosis type 2, with auditory brainstem implant placement. 62
36285231 2021
6
Anterior Petrosal Approach for the Resection of a Petrous Apex Meningioma with Tentorial Infiltration. 62
31143603 2019
7
Petrous Apex Meningioma with Extension into Meckel's Cave: Resection using a Retrosigmoid Intradural Suprameatal Approach. 62
31143601 2019
8
Role of surgery for small petrous apex meningiomas causing refractory trigeminal neuropathy in the minimally invasive era. 62
27625241 2016
9
Extended Suboccipital Retrosigmoid Surgical Approach Is Effective for Resection of Petrous Apex Meningioma. 62
27300453 2016
10
Anatomy of the superior petrosal veins and their exposure and management during petrous apex meningioma surgery using the lateral suboccipital retrosigmoid approach. 62
24781190 2014
11
Retrosigmoid approach for resection of petrous apex meningioma. 62
24380515 2014
12
The suprameatal dural flap for superior petrosal vein protection during the retrosigmoid intradural suprameatal approach. 62
23673670 2014
13
[Endoscopically assisted removal of posterior fossa meningioma combined with microvascular decompression of trigeminal nerve root (early experience)]. 62
22379855 2011
14
Microsurgical removal of a petrous apex meningioma after stereotactic radiation: technical case report. 62
11440447 2001
15
Removal of petrous apex meningioma and microvascular decompression for trigeminal neuralgia through the anterior petrosal approach. Case report. 62
10396120 1999
16
[The contribution of "time-of-flight" MRI-angiography in the study of neurovascular interactions (hemifacial spasm and trigeminal neuralgia)]. 62
9091607 1996
17
Combined and three-dimensional rendered multimodal data for planning cranial base surgery: a prospective evaluation. 62
7800138 1994
18
Facial nerve preservation in patients with large acoustic neuromas treated by a combined middle fossa transtentorial translabyrinthine approach. 62
6979613 1982
19
The superficial recurrent ophthalmic artery: meningeal supply to petrous ridge meningiomas. 62
450239 1979
20
Surgical management of petrous apex meningioma. 62
423660 1979

Variations for Petrous Apex Meningioma

Expression for Petrous Apex Meningioma

Search GEO for disease gene expression data for Petrous Apex Meningioma.

Pathways for Petrous Apex Meningioma

Pathways related to Petrous Apex Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.84 RDX PXN NF2 MSN EZR
2 11.64 RDX PXN MSN EZR
3 9.84 RDX MSN EZR

GO Terms for Petrous Apex Meningioma

Cellular components related to Petrous Apex Meningioma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.63 ADA AQP4 DHH ENG EPB41 EPB41L2
2 plasma membrane GO:0005887 10.63 AQP4 NTSR1
3 membrane GO:0016021 10.62 TREM1 NTSR1 KANTR EPB41 ENG AQP4
4 membrane GO:0016020 10.62 TREM1 TCHP RDX PDGFC NTSR1 NF2
5 cytoskeleton GO:0005856 10.15 TCHP RDX PXN NF2 MSN EZR
6 focal adhesion GO:0005925 10.1 ENG EPB41L2 EZR MSN PXN RDX
7 adherens junction GO:0005912 10.06 RDX NF2 MSN EZR
8 cell cortex GO:0005938 9.98 PXN EZR EPB41L2 EPB41
9 basolateral plasma membrane GO:0016323 9.96 MSN EZR ERBIN EPB41 AQP4
10 microvillus GO:0005902 9.95 EZR MSN RDX
11 uropod GO:0001931 9.8 MSN EZR
12 apical part of cell GO:0045177 9.76 RDX NF2 MSN EZR
13 filopodium GO:0030175 9.5 RDX NF2 MSN EZR
14 cell periphery GO:0071944 9.17 RDX NF2 MSN EZR

Biological processes related to Petrous Apex Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell shape GO:0008360 10.03 RDX MSN EZR EPB41
2 positive regulation of protein catabolic process GO:0045732 9.95 RDX MSN EZR
3 establishment of endothelial barrier GO:0061028 9.73 RDX MSN EZR
4 regulation of cell size GO:0008361 9.72 EZR MSN RDX
5 positive regulation of protein localization to cell cortex GO:1904778 9.71 EPB41L2 EPB41
6 membrane to membrane docking GO:0022614 9.67 MSN EZR
7 gland morphogenesis GO:0022612 9.63 MSN EZR
8 positive regulation of protein localization to early endosome GO:1902966 9.63 RDX MSN EZR
9 positive regulation of early endosome to late endosome transport GO:2000643 9.43 RDX MSN EZR
10 regulation of organelle assembly GO:1902115 9.1 RDX MSN EZR

Molecular functions related to Petrous Apex Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.73 RDX NF2 MSN EZR EPB41L2 EPB41
2 cell adhesion molecule binding GO:0050839 9.63 RDX MSN EZR
3 cytoskeletal protein binding GO:0008092 9.1 RDX NF2 MSN EZR EPB41L2 EPB41

Sources for Petrous Apex Meningioma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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