Aliases & Classifications for Peyronie Disease

MalaCards integrated aliases for Peyronie Disease:

Name: Peyronie Disease 56 74 54 71

Characteristics:

OMIM:

56
Inheritance:
male-limited, autosomal dominant


HPO:

31
peyronie disease:
Inheritance male-limited autosomal dominant


Classifications:



External Ids:

OMIM 56 171000
MedGen 41 C0030848
UMLS 71 C0030848

Summaries for Peyronie Disease

MalaCards based summary : Peyronie Disease is related to peyronie's disease and dupuytren contracture. An important gene associated with Peyronie Disease is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Pathways in cancer and Response to elevated platelet cytosolic Ca2+. The drugs Lidocaine and Chlorhexidine gluconate have been mentioned in the context of this disorder. Affiliated tissues include prostate, heart and small intestine, and related phenotypes are abnormality of the genitourinary system and dupuytren contracture

Wikipedia : 74 Peyronie's disease is a connective tissue disorder involving the growth of fibrous plaques in the soft... more...

More information from OMIM: 171000

Related Diseases for Peyronie Disease

Graphical network of the top 20 diseases related to Peyronie Disease:



Diseases related to Peyronie Disease

Symptoms & Phenotypes for Peyronie Disease

Human phenotypes related to Peyronie Disease:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the genitourinary system 31 HP:0000119
2 dupuytren contracture 31 HP:0005679

Symptoms via clinical synopsis from OMIM:

56
G U:
penile contracture

Limbs:
associated dupuytren contracture

Clinical features from OMIM:

171000

MGI Mouse Phenotypes related to Peyronie Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 DES NOS2 SOD1 TGFB1

Drugs & Therapeutics for Peyronie Disease

Drugs for Peyronie Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
2 Chlorhexidine gluconate Phase 2
3 Dermatologic Agents Phase 2
4 Anti-Infective Agents, Local Phase 2
5 Disinfectants Phase 2
6 Analgesics Phase 2
7 Anti-Infective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment Response to Xiaflex Based on Ultrasound Characterization of Plaque for Men With Peyronie's Disease Recruiting NCT03774264 Phase 4 Xiaflex
2 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) - a Randomized Trial Unknown status NCT01184586 Phase 2
3 Management of Urethral Injury During Penile Prosthesis Implantation: Urethral Sterilization With Chlorhexidine Digluconate to Facilitate Primary Repair and Same-Session Implantation Recruiting NCT03614429 Phase 2 Chlorhexidine gel will be prepared according to an international product Instillagel®
4 Does Size Matter: A Single Case Experimental Design of Limiting the Depth of Penetration During Intercourse Completed NCT04052217
5 A Prospective Randomized Double Blinded Placebo Controlled Clinical Trial Evaluating the Combined Effect of Low-Intensity Extracorporeal Shockwave Therapy (LI-ESWT) and Vacuum Erectile Device Combined With Manipulation Exercises on Peyronies Disease. Recruiting NCT03530540

Search NIH Clinical Center for Peyronie Disease

Genetic Tests for Peyronie Disease

Anatomical Context for Peyronie Disease

MalaCards organs/tissues related to Peyronie Disease:

40
Prostate, Heart, Small Intestine, Bone, Smooth Muscle, Kidney, Pituitary

Publications for Peyronie Disease

Articles related to Peyronie Disease:

(show top 50) (show all 164)
# Title Authors PMID Year
1
A brief historical survey of "Peyronie's disease". 56
18179461 2008
2
Peyronie's disease: advances in basic science and pathophysiology. 56
12084307 2000
3
A case-control study on risk factors for Peyronie's disease. 56
9636000 1998
4
Multiple clonal chromosome abnormalities in Peyronie's disease. 56
2021920 1991
5
Chromosome abnormalities in Peyronie's disease. 56
3560320 1987
6
Peyronie's disease: a newly recognized autosomal-dominant trait. 56
6213155 1982
7
Labetalol-induced Peyronie's disease? A case report. 56
231377 1979
8
Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease. 54 61
16093362 2005
9
Radiation Therapy for Benign Disease: Keloids, Macular Degeneration, Orbital Pseudotumor, Pterygium, Peyronie Disease, Trigeminal Neuralgia. 61
31739946 2020
10
Safety of Collagenase Clostridium histolyticum Injection Therapy for Peyronie Disease in Patients Continuing Antiplatelet or Anticoagulant Therapy. 61
31866126 2020
11
Penile Reconstructive Surgery in Peyronie Disease: Challenges in Restoring Normal Penis Size, Shape, and Function. 61
29623703 2020
12
Evaluation of Oral Pentoxifylline, Colchicine, and Penile Traction for the Management of Peyronie's Disease. 61
31445974 2019
13
Dupuytren contracture as a sign of systemic disease. 61
31864447 2019
14
Consulting "Dr Google" for sexual dysfunction: a contemporary worldwide trend analysis. 61
31591474 2019
15
[Penile prosthesis implantation through subcoronal approach with graft-free corporoplasty in patients with Peyronie disease with concomitant erectile dysfunction]. 61
31356025 2019
16
Are Platelet Indices such as Platelet Volume, Platelet Distribution Width, and Plateletcrit Associated with Peyronie Disease? 61
31385470 2019
17
Administration of Adipose Derived Mesenchymal Stem Cells and Platelet Lysate in Erectile Dysfunction: A Single Center Pilot Study. 61
30841525 2019
18
Diagnosis and Treatment of Peyronie Disease With Both Dorsal and Ventral Plaques Using Doppler Ultrasound: NYU Case of the Month, July 2019. 61
31768141 2019
19
Suppression of Cavernosal Fibrosis in a Rat Model. 61
29631978 2018
20
Separating the Wheat From the Chaff: An Evaluation of Readability, Quality, and Accuracy of Online Health Information for Treatment of Peyronie Disease. 61
29723588 2018
21
A Comparative Study Between 2 Different Grafts Used as Patches After Plaque Incision and Inflatable Penile Prosthesis Implantation for End-Stage Peyronie's Disease. 61
29753801 2018
22
A Novel Noninvasive Ultrasound Vibro-elastography Technique for Assessing Patients With Erectile Dysfunction and Peyronie Disease. 61
29548864 2018
23
Re: Clinical Experience with Penile Traction Therapy among Men Undergoing Collagenase Clostridium Histolyticum for Peyronie Disease. 61
29310171 2018
24
Penile Doppler ultrasonography revisited. 61
28736428 2018
25
Re: Factors Associated with Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients with Peyronie Disease. 61
29144914 2017
26
Successful Treatment of Residual Curvature in Peyronie Disease in Men Previously Treated With Intralesional Collagenase Clostridium Histolyticum. 61
28886994 2017
27
Re: Small Intestinal Submucosa Grafting for Peyronie Disease: Outcomes and Patient Satisfaction. 61
29059762 2017
28
Re: Clinical Experience with Penile Traction Therapy among Men Undergoing Collagenase Clostridium histolyticum for Peyronie Disease. 61
28817884 2017
29
Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease. 61
28554517 2017
30
Penile Plication With or Without Degloving of the Penis Results in Similar Outcomes. 61
28711404 2017
31
Self-reported Clinical Meaningfulness Early in the Treatment Course Predicts Objective Outcomes in Men Undergoing Collagenase Clostridium histolyticum Injections for Peyronie Disease. 61
28483591 2017
32
Safety Profile of Collagenase Clostridium Histolyticum Stratified by Degree of Penile Curvature in Patients With Peyronie Disease. 61
28502596 2017
33
Clinical Experience With Penile Traction Therapy Among Men Undergoing Collagenase Clostridium histolyticum for Peyronie Disease. 61
28347795 2017
34
Low-Intensity Extracorporeal Shockwave Therapy in Sexual Medicine: A Questionnaire-Based Assessment of Knowledge, Clinical Practice Patterns, and Attitudes in Sexual Medicine Practitioners. 61
28268167 2017
35
Stem Cells in Male Sexual Dysfunction: Are We Getting Somewhere? 61
28041853 2017
36
Impact of Number of Cycles of Collagenase Clostridium Histolyticum on Outcomes in Patients With Peyronie's Disease. 61
27816605 2017
37
Small Intestinal Submucosa Grafting for Peyronie Disease: Outcomes and Patient Satisfaction. 61
27825744 2017
38
Penile ossification: A reconstructive challenge. 61
28522935 2017
39
Dupuytren-Like Contracture of the Foot: Ledderhose Disease. 61
28825000 2016
40
Partial Plaque Excision and Grafting With Collagen Fleece in Peyronie Disease. 61
26953837 2016
41
The Genetic Basis of Peyronie Disease: A Review. 61
27872008 2016
42
Effects of Stem Cell Treatment in Human Patients With Peyronie Disease. 61
26414724 2015
43
Intralesional Injections for Early Peyronie Disease: Standardized Assessment and Analysis of Predictive Factors for Treatment Response. 61
26142583 2015
44
Re: Corporoplasty Using Buccal Mucosa Graft in Peyronie Disease: Is it a First Choice? 61
26088238 2015
45
Prospects of stem cell treatment in benign urological diseases. 61
25874038 2015
46
Corporoplasty using buccal mucosa graft in Peyronie disease: is it a first choice? 61
25582815 2015
47
Lingual mucosal graft in treatment of Peyronie disease. 61
25283703 2014
48
The anti-inflammatory and antifibrosis effects of anthocyanin extracted from black soybean on a Peyronie disease rat model. 61
25156514 2014
49
[Induratio penis plastica and the capability of vaginal penetration in the context of forensic evaluation]. 61
25341246 2014
50
Re: clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies: M. Gelbard, I. Goldstein, W. J. Hellstrom, C. G. McMahon, T. Smith, J. Tursi, N. Jones, G. J. Kaufman and C. C. Carson, III J Urol 2013; 190: 199-207. 61
24239419 2014

Variations for Peyronie Disease

Expression for Peyronie Disease

Search GEO for disease gene expression data for Peyronie Disease.

Pathways for Peyronie Disease

GO Terms for Peyronie Disease

Cellular components related to Peyronie Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 TGFB1 SOD1

Biological processes related to Peyronie Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.5 TGFB1 NOS2 IFNA2
2 response to organic substance GO:0010033 9.43 TGFB1 SOD1
3 negative regulation of gene expression GO:0010629 9.43 TGFB1 NOS2 IFNA2
4 positive regulation of MAP kinase activity GO:0043406 9.4 TGFB1 PDE5A
5 negative regulation of T cell proliferation GO:0042130 9.37 TGFB1 PDE5A
6 muscle cell cellular homeostasis GO:0046716 9.16 TGFB1 SOD1
7 superoxide metabolic process GO:0006801 8.96 SOD1 NOS2
8 positive regulation of superoxide anion generation GO:0032930 8.62 TGFB1 SOD1

Sources for Peyronie Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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