Phacogenic Glaucoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Phacogenic Glaucoma

MalaCards integrated aliases for Phacogenic Glaucoma:

Name: Phacogenic Glaucoma ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:12571

ICD9CM ³⁵ 365.59

SNOMED-CT ⁶⁸ 84333006

UMLS ⁷³ C0154959 C0271142

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Summaries for Phacogenic Glaucoma

MalaCards based summary : Phacogenic Glaucoma is related to morgagni cataract and pseudoxanthoma elasticum-like papillary dermal elastolysis. An important gene associated with Phacogenic Glaucoma is LOXL1 (Lysyl Oxidase Like 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include eye and heart, and related phenotype is behavior/neurological.

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Related Diseases for Phacogenic Glaucoma

Diseases related to Phacogenic Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)

#	Related Disease	Score	Top Affiliating Genes
1	morgagni cataract	10.2	CRYAA PHEX
2	pseudoxanthoma elasticum-like papillary dermal elastolysis	10.1	ELN FBN1
3	late-onset focal dermal elastosis	10.1	ELN FBN1
4	familial abdominal aortic aneurysm	10.1	ELN FBN1
5	tricuspid valve prolapse	10.1	FBN1 PHEX
6	chronic actinic dermatitis	10.1	ELN FBN1
7	traumatic glaucoma	10.1	OPTN PHEX
8	chronic closed-angle glaucoma	10.1	OPTN PHEX
9	mid-dermal elastolysis	10.1	ELN FBN1
10	glaucoma, normal tension	10.1	LOXL1 OPTN
11	supravalvular aortic stenosis	10.1	ELN FBN1
12	acute closed-angle glaucoma	10.1	OPTN PEX19
13	aortic valve insufficiency	10.1	ELN FBN1
14	low tension glaucoma	10.1	OPTN PHEX
15	sorsby fundus dystrophy	10.1	ELN FBN1
16	autosomal recessive cutis laxa type i	10.1	ELN LOX
17	vernal conjunctivitis	10.1	LOXL1 OPTN
18	cutis laxa, autosomal recessive, type ib	10.1	ELN LOX
19	aortic aneurysm, familial thoracic 1	10.1	ELN FBN1
20	pneumothorax	10.0	ELN FBN1
21	cutis laxa, autosomal dominant 1	10.0	ELN FBN1
22	juvenile glaucoma	10.0	ELN OPTN PHEX
23	open-angle glaucoma	10.0	ELN LOXL1 OPTN
24	menkes disease	10.0	ELN LOX
25	heart valve disease	10.0	ELN FBN1
26	pelvic organ prolapse	10.0	ELN LOX LOXL1
27	loeys-dietz syndrome 3	10.0	FBN1 LOX
28	optic nerve neoplasm	10.0	LOX OPTN
29	autosomal recessive cutis laxa type iii	10.0	ELN FBN1 OPTN
30	optic nerve glioma	9.9	LOX OPTN
31	uveal disease	9.9	LOXL1 OPTN PEX19 PHEX
32	glaucoma, primary open angle	9.9	ELN LOXL1 OPTN PHEX
33	aortic aneurysm	9.9	ELN FBN1 LOX
34	intracranial aneurysm	9.9	ELN LOX
35	aortic disease	9.9	ELN FBN1
36	iris disease	9.8	CRYAA LOXL1 OPTN PEX19 PHEX
37	lens disease	9.7	CRYAA FBN1 OPTN PEX19 PHEX
38	exfoliation syndrome	9.2	CLU CNTNAP2 ELN FBN1 LOX LOXL1

Graphical network of the top 20 diseases related to Phacogenic Glaucoma:

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Symptoms & Phenotypes for Phacogenic Glaucoma

MGI Mouse Phenotypes related to Phacogenic Glaucoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.23	CLU CNTNAP2 FBN1 LOX LOXL1 LYST

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Drugs & Therapeutics for Phacogenic Glaucoma

Search Clinical Trials , NIH Clinical Center for Phacogenic Glaucoma

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Genetic Tests for Phacogenic Glaucoma

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Anatomical Context for Phacogenic Glaucoma

MalaCards organs/tissues related to Phacogenic Glaucoma:

⁴¹

Eye, Heart

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Publications for Phacogenic Glaucoma

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Genes for Phacogenic Glaucoma

Genes related to Phacogenic Glaucoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LOXL1	Lysyl Oxidase Like 1	Protein Coding	19.49	DISEASES inferred ¹⁵
2	PHEX	Phosphate Regulating Endopeptidase Homolog X-Linked	Protein Coding	19.32	DISEASES inferred ¹⁵
3	PEX19	Peroxisomal Biogenesis Factor 19	Protein Coding	18.1	DISEASES inferred ¹⁵
4	ELN	Elastin	Protein Coding	16.05	DISEASES inferred ¹⁵
5	CRYAA	Crystallin Alpha A	Protein Coding	16.02	DISEASES inferred ¹⁵
6	CLU	Clusterin	Protein Coding	15.83	DISEASES inferred ¹⁵
7	LYST	Lysosomal Trafficking Regulator	Protein Coding	15.79	DISEASES inferred ¹⁵
8	FBN1	Fibrillin 1	Protein Coding	15.61	DISEASES inferred ¹⁵
9	OPTN	Optineurin	Protein Coding	15.3	DISEASES inferred ¹⁵
10	LOX	Lysyl Oxidase	Protein Coding	15.22	DISEASES inferred ¹⁵
11	CNTNAP2	Contactin Associated Protein Like 2	Protein Coding	15.18	DISEASES inferred ¹⁵
12	TMEM136	Transmembrane Protein 136	Protein Coding	6.58	DISEASES inferred ¹⁵

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Variations for Phacogenic Glaucoma

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Expression for Phacogenic Glaucoma

Search GEO for disease gene expression data for Phacogenic Glaucoma.

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Pathways for Phacogenic Glaucoma

Pathways related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁶ Show member pathways Collagen degradation ⁶⁶ Extracellular matrix organization ⁶⁶	11.91	ELN FBN1 LOX LOXL1
2	Elastic fibre formation ⁶⁶ Show member pathways Molecules associated with elastic fibres ⁶⁶	10.79	ELN FBN1 LOX LOXL1

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GO Terms for Phacogenic Glaucoma

Cellular components related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	collagen-containing extracellular matrix	GO:0062023	9.26	CLU ELN FBN1 LOXL1
2	extracellular matrix	GO:0031012	9.02	CLU ELN FBN1 LOX LOXL1

Biological processes related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein stabilization	GO:0050821	9.33	CLU CRYAA PEX19
2	chaperone-mediated protein folding	GO:0061077	9.26	CLU PEX19
3	aorta development	GO:0035904	8.96	LOX LOXL1
4	peptidyl-lysine oxidation	GO:0018057	8.62	LOX LOXL1

Molecular functions related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	copper ion binding	GO:0005507	9.26	LOX LOXL1
2	extracellular matrix constituent conferring elasticity	GO:0030023	9.16	ELN FBN1
3	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	GO:0016641	8.96	LOX LOXL1
4	protein-lysine 6-oxidase activity	GO:0004720	8.62	LOX LOXL1

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Sources for Phacogenic Glaucoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia