MCID: PHC002
MIFTS: 21

Phacogenic Glaucoma

Categories: Eye diseases

Aliases & Classifications for Phacogenic Glaucoma

MalaCards integrated aliases for Phacogenic Glaucoma:

Name: Phacogenic Glaucoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12571
ICD9CM 35 365.59
SNOMED-CT 68 84333006

Summaries for Phacogenic Glaucoma

MalaCards based summary : Phacogenic Glaucoma is related to morgagni cataract and pseudoxanthoma elasticum-like papillary dermal elastolysis. An important gene associated with Phacogenic Glaucoma is LOXL1 (Lysyl Oxidase Like 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include eye and heart, and related phenotype is behavior/neurological.

Related Diseases for Phacogenic Glaucoma

Diseases related to Phacogenic Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 morgagni cataract 10.2 CRYAA PHEX
2 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.1 ELN FBN1
3 late-onset focal dermal elastosis 10.1 ELN FBN1
4 familial abdominal aortic aneurysm 10.1 ELN FBN1
5 tricuspid valve prolapse 10.1 FBN1 PHEX
6 chronic actinic dermatitis 10.1 ELN FBN1
7 traumatic glaucoma 10.1 OPTN PHEX
8 chronic closed-angle glaucoma 10.1 OPTN PHEX
9 mid-dermal elastolysis 10.1 ELN FBN1
10 glaucoma, normal tension 10.1 LOXL1 OPTN
11 supravalvular aortic stenosis 10.1 ELN FBN1
12 acute closed-angle glaucoma 10.1 OPTN PEX19
13 aortic valve insufficiency 10.1 ELN FBN1
14 low tension glaucoma 10.1 OPTN PHEX
15 sorsby fundus dystrophy 10.1 ELN FBN1
16 autosomal recessive cutis laxa type i 10.1 ELN LOX
17 vernal conjunctivitis 10.1 LOXL1 OPTN
18 cutis laxa, autosomal recessive, type ib 10.1 ELN LOX
19 aortic aneurysm, familial thoracic 1 10.1 ELN FBN1
20 pneumothorax 10.0 ELN FBN1
21 cutis laxa, autosomal dominant 1 10.0 ELN FBN1
22 juvenile glaucoma 10.0 ELN OPTN PHEX
23 open-angle glaucoma 10.0 ELN LOXL1 OPTN
24 menkes disease 10.0 ELN LOX
25 heart valve disease 10.0 ELN FBN1
26 pelvic organ prolapse 10.0 ELN LOX LOXL1
27 loeys-dietz syndrome 3 10.0 FBN1 LOX
28 optic nerve neoplasm 10.0 LOX OPTN
29 autosomal recessive cutis laxa type iii 10.0 ELN FBN1 OPTN
30 optic nerve glioma 9.9 LOX OPTN
31 uveal disease 9.9 LOXL1 OPTN PEX19 PHEX
32 glaucoma, primary open angle 9.9 ELN LOXL1 OPTN PHEX
33 aortic aneurysm 9.9 ELN FBN1 LOX
34 intracranial aneurysm 9.9 ELN LOX
35 aortic disease 9.9 ELN FBN1
36 iris disease 9.8 CRYAA LOXL1 OPTN PEX19 PHEX
37 lens disease 9.7 CRYAA FBN1 OPTN PEX19 PHEX
38 exfoliation syndrome 9.2 CLU CNTNAP2 ELN FBN1 LOX LOXL1

Graphical network of the top 20 diseases related to Phacogenic Glaucoma:



Diseases related to Phacogenic Glaucoma

Symptoms & Phenotypes for Phacogenic Glaucoma

MGI Mouse Phenotypes related to Phacogenic Glaucoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.23 CLU CNTNAP2 FBN1 LOX LOXL1 LYST

Drugs & Therapeutics for Phacogenic Glaucoma

Search Clinical Trials , NIH Clinical Center for Phacogenic Glaucoma

Genetic Tests for Phacogenic Glaucoma

Anatomical Context for Phacogenic Glaucoma

MalaCards organs/tissues related to Phacogenic Glaucoma:

41
Eye, Heart

Publications for Phacogenic Glaucoma

Variations for Phacogenic Glaucoma

Expression for Phacogenic Glaucoma

Search GEO for disease gene expression data for Phacogenic Glaucoma.

Pathways for Phacogenic Glaucoma

Pathways related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 ELN FBN1 LOX LOXL1
2
Show member pathways
10.79 ELN FBN1 LOX LOXL1

GO Terms for Phacogenic Glaucoma

Cellular components related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.26 CLU ELN FBN1 LOXL1
2 extracellular matrix GO:0031012 9.02 CLU ELN FBN1 LOX LOXL1

Biological processes related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 9.33 CLU CRYAA PEX19
2 chaperone-mediated protein folding GO:0061077 9.26 CLU PEX19
3 aorta development GO:0035904 8.96 LOX LOXL1
4 peptidyl-lysine oxidation GO:0018057 8.62 LOX LOXL1

Molecular functions related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.26 LOX LOXL1
2 extracellular matrix constituent conferring elasticity GO:0030023 9.16 ELN FBN1
3 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 8.96 LOX LOXL1
4 protein-lysine 6-oxidase activity GO:0004720 8.62 LOX LOXL1

Sources for Phacogenic Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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