MCID: PHC002
MIFTS: 25

Phacogenic Glaucoma

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Phacogenic Glaucoma

MalaCards integrated aliases for Phacogenic Glaucoma:

Name: Phacogenic Glaucoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12571
ICD9CM 34 365.59
SNOMED-CT 67 84333006
UMLS 71 C0154959 C0271142

Summaries for Phacogenic Glaucoma

Disease Ontology : 12 A glaucoma characterized by glaucomatous optic atrophy secondary to a lens abnormality and has symptom progressive decreased vision, especially decreased peripheral vision. Phacogenic glaucoma can be caused by cataracts, trauma to the eye, or age-related damage that obstructs aqueous outflow, leading to inappropriately increased intraocular pressure and eventual optic nerve atrophy with associated vision loss.

MalaCards based summary : Phacogenic Glaucoma is related to exfoliation syndrome and phacolytic glaucoma, and has symptoms including progressive decreased vision An important gene associated with Phacogenic Glaucoma is LOXL1 (Lysyl Oxidase Like 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. Affiliated tissues include eye, and related phenotypes are craniofacial and respiratory system

Related Diseases for Phacogenic Glaucoma

Diseases related to Phacogenic Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 exfoliation syndrome 30.5 TLCD5 SERPINA3 LYST LTBP2 LOXL1-AS1 LOXL1
2 phacolytic glaucoma 11.1
3 morgagni cataract 10.4 LOXL1 CRYAA
4 late-onset focal dermal elastosis 10.4 FBN1 ELN
5 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.4 FBN1 ELN
6 familial abdominal aortic aneurysm 10.3 FBN1 ELN
7 chronic actinic dermatitis 10.3 FBN1 ELN
8 glaucoma, primary closed-angle 10.3 MYOC CLU
9 hemopericardium 10.3 FBN1 ELN
10 cone-rod dystrophy, x-linked, 3 10.3 SERPINA3 CRYAA
11 glaucoma 1, open angle, a 10.3 OPTN MYOC
12 acquired cutis laxa 10.3 FBLN5 ELN
13 histiocytic and dendritic cell cancer 10.3 SERPINA3 CLU
14 acute closed-angle glaucoma 10.3 OPTN MYOC
15 collagen disease 10.2 SERPINA3 FBN1 ELN
16 nanophthalmos 10.2 WDR36 MYOC LOXL1
17 geleophysic dysplasia 3 10.2 LTBP3 LTBP2
18 microphthalmia, isolated 2 10.2 WDR36 MYOC
19 nodular tenosynovitis 10.2 SERPINA3 CLU
20 uveal disease 10.2 SERPINA3 MYOC LOXL1 CRYAA
21 witkop syndrome 10.2 LTBP3 LTBP2
22 fbln5-related cutis laxa 10.2 FBLN5 ELN
23 chronic closed-angle glaucoma 10.2 TGFB2 MYOC LOXL1
24 heart valve disease 10.2 SERPINA3 FBN1 ELN
25 neovascular glaucoma 10.2 TGFB2 MYOC CRYAA
26 peripheral retinal degeneration 10.2 WDR36 MYOC
27 glaucoma 1, open angle, d 10.2 OPTN MYOC LTBP2
28 aortic valve disease 2 10.2 SERPINA3 FBN1 ELN
29 homocysteinemia 10.2 FBN1 ELN CLU
30 lens subluxation 10.2 LTBP2 LOXL1 FBN1 CRYAA
31 stickler syndrome 10.2 LOXL1 FBN1 ELN CRYAA
32 geleophysic dysplasia 1 10.2 LTBP3 LTBP2 FBN1
33 cutis laxa, autosomal recessive, type ib 10.2 FBN1 FBLN5
34 loeys-dietz syndrome 5 10.2 TGFB2 FBN1
35 cutis laxa, autosomal recessive, type ia 10.2 LOXL1 FBN1 FBLN5
36 geleophysic dysplasia 2 10.2 LTBP3 LTBP2 FBN1
37 corneal disease 10.2 TGFB2 SERPINA3 CRYAA
38 mid-dermal elastolysis 10.2 FBN1 FBLN5 ELN
39 ehlers-danlos syndrome, vascular type 10.1 TGFB2 FBN1 ELN
40 autosomal recessive cutis laxa type ii classic type 10.1 FBN1 FBLN5 ELN
41 traumatic glaucoma 10.1 TMCO1 MYOC LTBP2 LOXL1
42 bladder diverticulum 10.1 LOX FBLN5 ELN
43 supravalvular aortic stenosis 10.1 FBN1 FBLN5 ELN
44 tenosynovial giant cell tumor 10.1 SERPINA3 CLU
45 heritable thoracic aortic disease 10.1 TGFB2 LOX FBN1
46 cutis laxa, autosomal dominant 1 10.1 FBN1 FBLN5 ELN
47 pneumothorax 10.1 FBN1 FBLN5 ELN
48 occipital horn syndrome 10.1 LOX FBLN5 ELN
49 aortic aneurysm, familial abdominal, 1 10.1 SERPINA3 LOX FBN1 ELN
50 orthostatic intolerance 10.1 TGFB2 FBN1 ELN

Graphical network of the top 20 diseases related to Phacogenic Glaucoma:



Diseases related to Phacogenic Glaucoma

Symptoms & Phenotypes for Phacogenic Glaucoma

Symptoms:

12
  • progressive decreased vision

MGI Mouse Phenotypes related to Phacogenic Glaucoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.56 FBLN5 FBN1 LOX LTBP1 LTBP3 LYST
2 respiratory system MP:0005388 9.23 FBLN5 FBN1 LOX LOXL1 LTBP2 LTBP3

Drugs & Therapeutics for Phacogenic Glaucoma

Search Clinical Trials , NIH Clinical Center for Phacogenic Glaucoma

Genetic Tests for Phacogenic Glaucoma

Anatomical Context for Phacogenic Glaucoma

MalaCards organs/tissues related to Phacogenic Glaucoma:

40
Eye

Publications for Phacogenic Glaucoma

Articles related to Phacogenic Glaucoma:

# Title Authors PMID Year
1
[Glaucoma in Marfan syndrome: position-dependent measurement of intraocular pressure as a diagnostic criterium]. 61
8583753 1995

Variations for Phacogenic Glaucoma

Expression for Phacogenic Glaucoma

Search GEO for disease gene expression data for Phacogenic Glaucoma.

Pathways for Phacogenic Glaucoma

GO Terms for Phacogenic Glaucoma

Cellular components related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TGFB2 SERPINA3 MYOC LTBP3 LTBP2 LTBP1
2 extracellular space GO:0005615 9.91 TGFB2 SERPINA3 MYOC LTBP2 LOXL1 LOX
3 platelet alpha granule lumen GO:0031093 9.54 TGFB2 SERPINA3 CLU
4 extracellular matrix GO:0031012 9.5 LTBP2 LTBP1 LOXL1 LOX FBN1 FBLN5
5 microfibril GO:0001527 9.4 LTBP1 FBN1
6 collagen-containing extracellular matrix GO:0062023 9.36 TGFB2 SERPINA3 MYOC LTBP3 LTBP2 LTBP1
7 elastic fiber GO:0071953 9.32 FBLN5 ELN

Biological processes related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.58 TGFB2 SERPINA3 CLU
2 transforming growth factor beta receptor signaling pathway GO:0007179 9.54 TGFB2 LTBP3 LTBP2
3 collagen fibril organization GO:0030199 9.5 TGFB2 LOXL1 LOX
4 extracellular matrix organization GO:0030198 9.35 LOXL1 LOX FBN1 FBLN5 ELN
5 peptidyl-lysine oxidation GO:0018057 9.26 LOXL1 LOX
6 sequestering of TGFbeta in extracellular matrix GO:0035583 9.16 LTBP1 FBN1
7 elastic fiber assembly GO:0048251 8.8 LTBP3 LOX FBLN5

Molecular functions related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 9.43 LTBP3 LTBP2 LTBP1
2 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 9.37 LOXL1 LOX
3 protein-lysine 6-oxidase activity GO:0004720 9.32 LOXL1 LOX
4 extracellular matrix structural constituent GO:0005201 9.26 LTBP2 LTBP1 FBN1 ELN
5 microfibril binding GO:0050436 9.16 LTBP2 LTBP1
6 extracellular matrix constituent conferring elasticity GO:0030023 8.8 FBN1 FBLN5 ELN

Sources for Phacogenic Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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