Phacogenic Glaucoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Phacogenic Glaucoma

MalaCards integrated aliases for Phacogenic Glaucoma:

Name: Phacogenic Glaucoma ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:12571

ICD9CM ³⁴ 365.59

SNOMED-CT ⁶⁷ 84333006

UMLS ⁷⁰ C0154959 C0271142

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Summaries for Phacogenic Glaucoma

Disease Ontology : ¹² A glaucoma characterized by glaucomatous optic atrophy secondary to a lens abnormality and has symptom progressive decreased vision, especially decreased peripheral vision. Phacogenic glaucoma can be caused by cataracts, trauma to the eye, or age-related damage that obstructs aqueous outflow, leading to inappropriately increased intraocular pressure and eventual optic nerve atrophy with associated vision loss.

MalaCards based summary : Phacogenic Glaucoma is related to exfoliation syndrome and phacolytic glaucoma, and has symptoms including progressive decreased vision An important gene associated with Phacogenic Glaucoma is LOXL1 (Lysyl Oxidase Like 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. Affiliated tissues include eye, brain and heart, and related phenotypes are craniofacial and respiratory system

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Related Diseases for Phacogenic Glaucoma

Diseases related to Phacogenic Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)

#	Related Disease	Score	Top Affiliating Genes
1	exfoliation syndrome	30.5	TLCD5 SERPINA3 LYST LTBP2 LOXL1-AS1 LOXL1
2	phacolytic glaucoma	11.1
3	morgagni cataract	10.4	LOXL1 CRYAA
4	late-onset focal dermal elastosis	10.4	FBN1 ELN
5	pseudoxanthoma elasticum-like papillary dermal elastolysis	10.4	FBN1 ELN
6	familial abdominal aortic aneurysm	10.3	FBN1 ELN
7	chronic actinic dermatitis	10.3	FBN1 ELN
8	cone-rod dystrophy, x-linked, 3	10.3	SERPINA3 CRYAA
9	glaucoma, primary closed-angle	10.3	MYOC CLU
10	hemopericardium	10.3	FBN1 ELN
11	glaucoma 1, open angle, a	10.3	OPTN MYOC
12	acquired cutis laxa	10.3	FBLN5 ELN
13	histiocytic and dendritic cell cancer	10.3	SERPINA3 CLU
14	acute closed-angle glaucoma	10.3	OPTN MYOC
15	nanophthalmos	10.2	WDR36 MYOC LOXL1
16	microphthalmia, isolated 2	10.2	WDR36 MYOC
17	geleophysic dysplasia 3	10.2	LTBP3 LTBP2
18	collagen disease	10.2	SERPINA3 FBN1 ELN
19	nodular tenosynovitis	10.2	SERPINA3 CLU
20	witkop syndrome	10.2	LTBP3 LTBP2
21	uveal disease	10.2	SERPINA3 MYOC LOXL1 CRYAA
22	chronic closed-angle glaucoma	10.2	TGFB2 MYOC LOXL1
23	fbln5-related cutis laxa	10.2	FBLN5 ELN
24	heart valve disease	10.2	SERPINA3 FBN1 ELN
25	neovascular glaucoma	10.2	TGFB2 MYOC CRYAA
26	peripheral retinal degeneration	10.2	WDR36 MYOC
27	glaucoma 1, open angle, d	10.2	OPTN MYOC LTBP2
28	aortic valve disease 2	10.2	SERPINA3 FBN1 ELN
29	homocysteinemia	10.2	FBN1 ELN CLU
30	lens subluxation	10.2	LTBP2 LOXL1 FBN1 CRYAA
31	stickler syndrome	10.2	LOXL1 FBN1 ELN CRYAA
32	geleophysic dysplasia 1	10.2	LTBP3 LTBP2 FBN1
33	corneal disease	10.2	TGFB2 SERPINA3 CRYAA
34	geleophysic dysplasia 2	10.2	LTBP3 LTBP2 FBN1
35	loeys-dietz syndrome 5	10.2	TGFB2 FBN1
36	ehlers-danlos syndrome, vascular type	10.2	TGFB2 FBN1 ELN
37	mid-dermal elastolysis	10.2	FBN1 FBLN5 ELN
38	tenosynovial giant cell tumor	10.2	SERPINA3 CLU
39	cutis laxa, autosomal recessive, type ib	10.1	FBN1 FBLN5 ELN
40	autosomal recessive cutis laxa type ii classic type	10.1	FBN1 FBLN5 ELN
41	traumatic glaucoma	10.1	TMCO1 MYOC LTBP2 LOXL1
42	bladder diverticulum	10.1	LOX FBLN5 ELN
43	entropion	10.1	FBLN5 CRYAA
44	supravalvular aortic stenosis	10.1	FBN1 FBLN5 ELN
45	cutis laxa, autosomal dominant 1	10.1	FBN1 FBLN5 ELN
46	pneumothorax	10.1	FBN1 FBLN5 ELN
47	occipital horn syndrome	10.1	LOX FBLN5 ELN
48	aortic aneurysm, familial abdominal, 1	10.1	SERPINA3 LOX FBN1 ELN
49	aniridia 1	10.1	MYOC LTBP3 LTBP2 CRYAA
50	excessive tearing	10.1	WDR36 MYOC LTBP3 LTBP2

Graphical network of the top 20 diseases related to Phacogenic Glaucoma:

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Symptoms & Phenotypes for Phacogenic Glaucoma

Symptoms:

¹²

• progressive decreased vision

MGI Mouse Phenotypes related to Phacogenic Glaucoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.56	FBLN5 FBN1 LOX LTBP1 LTBP3 LYST
2	respiratory system	MP:0005388	9.23	FBLN5 FBN1 LOX LOXL1 LTBP2 LTBP3

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Drugs & Therapeutics for Phacogenic Glaucoma

Search Clinical Trials , NIH Clinical Center for Phacogenic Glaucoma

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Genetic Tests for Phacogenic Glaucoma

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Anatomical Context for Phacogenic Glaucoma

MalaCards organs/tissues related to Phacogenic Glaucoma:

⁴⁰

Eye, Brain, Heart, Skin

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Publications for Phacogenic Glaucoma

Articles related to Phacogenic Glaucoma:

#	Title	Authors	PMID	Year
1	[Glaucoma in Marfan syndrome: position-dependent measurement of intraocular pressure as a diagnostic criterium]. ⁶¹	Schlote T...Thiel HJ	8583753	1995

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Genes for Phacogenic Glaucoma

Genes related to Phacogenic Glaucoma (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LOXL1	Lysyl Oxidase Like 1	Protein Coding	9.9	DISEASES inferred ¹⁵
2	CRYAA	Crystallin Alpha A	Protein Coding	9.23	DISEASES inferred ¹⁵ ¹⁵
3	SERPINA3	Serpin Family A Member 3	Protein Coding	7.86	DISEASES inferred ¹⁵ ¹⁵
4	MYOC	Myocilin	Protein Coding	7.48	DISEASES inferred ¹⁵
5	ELN	Elastin	Protein Coding	7.2	DISEASES inferred ¹⁵
6	TLCD5	TLC Domain Containing 5	Protein Coding	7.18	DISEASES inferred ¹⁵
7	LOXL1-AS1	LOXL1 Antisense RNA 1	RNA Gene	7.14	DISEASES inferred ¹⁵
8	WDR36	WD Repeat Domain 36	Protein Coding	7.06	DISEASES inferred ¹⁵
9	LTBP2	Latent Transforming Growth Factor Beta Binding Protein 2	Protein Coding	6.95	DISEASES inferred ¹⁵
10	FBN1	Fibrillin 1	Protein Coding	6.8	DISEASES inferred ¹⁵
11	CLU	Clusterin	Protein Coding	6.67	DISEASES inferred ¹⁵
12	LOX	Lysyl Oxidase	Protein Coding	6.58	DISEASES inferred ¹⁵
13	OPTN	Optineurin	Protein Coding	6.57	DISEASES inferred ¹⁵
14	TMCO1	Transmembrane And Coiled-Coil Domains 1	Protein Coding	6.53	DISEASES inferred ¹⁵
15	LTBP3	Latent Transforming Growth Factor Beta Binding Protein 3	Protein Coding	6.42	DISEASES inferred ¹⁵
16	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	6.24	DISEASES inferred ¹⁵
17	FBLN5	Fibulin 5	Protein Coding	6.18	DISEASES inferred ¹⁵
18	LTBP1	Latent Transforming Growth Factor Beta Binding Protein 1	Protein Coding	6.1	DISEASES inferred ¹⁵
19	OR11L1	Olfactory Receptor Family 11 Subfamily L Member 1	Protein Coding	6.09	DISEASES inferred ¹⁵
20	LYST	Lysosomal Trafficking Regulator	Protein Coding	6.04	DISEASES inferred ¹⁵
21	LOXL4	Lysyl Oxidase Like 4	Protein Coding	6.01	DISEASES inferred ¹⁵
22	FOXC1	Forkhead Box C1	Protein Coding	5.99	DISEASES inferred ¹⁵

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Variations for Phacogenic Glaucoma

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Expression for Phacogenic Glaucoma

Search GEO for disease gene expression data for Phacogenic Glaucoma.

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Pathways for Phacogenic Glaucoma

Pathways related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Phospholipase-C Pathway ⁶³ Show member pathways PTEN Pathway ⁶³	12.69	TGFB2 LTBP3 LTBP2 LTBP1 FBN1 ELN
2	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.26	TGFB2 LTBP3 LTBP2 LTBP1 LOXL1 LOX
3	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	11.94	TGFB2 LTBP3 LTBP2 LTBP1
4	TGF-beta signaling pathway (KEGG) ³⁶	11.52	TGFB2 LTBP1 FBN1
5	G-protein signaling_RhoA regulation pathway ²³	11.4	TGFB2 LTBP3 LTBP2 LTBP1
6	Elastic fibre formation ⁶⁵ Show member pathways Molecules associated with elastic fibres ⁶⁵	11.14	TGFB2 LTBP3 LTBP2 LTBP1 LOXL1 LOX
7	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease ¹	10.73	LTBP2 LTBP1 FBN1
8	G-protein signaling_Rap2B regulation pathway ²³	10.64	TGFB2 LTBP3 LTBP2 LTBP1 FBN1 ELN

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GO Terms for Phacogenic Glaucoma

Cellular components related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.93	TGFB2 SERPINA3 MYOC LTBP3 LTBP2 LTBP1
2	extracellular space	GO:0005615	9.91	TGFB2 SERPINA3 MYOC LTBP2 LOXL1 LOX
3	platelet alpha granule lumen	GO:0031093	9.54	TGFB2 SERPINA3 CLU
4	extracellular matrix	GO:0031012	9.5	LTBP2 LTBP1 LOXL1 LOX FBN1 FBLN5
5	microfibril	GO:0001527	9.4	LTBP1 FBN1
6	collagen-containing extracellular matrix	GO:0062023	9.36	TGFB2 SERPINA3 MYOC LTBP3 LTBP2 LTBP1
7	elastic fiber	GO:0071953	9.32	FBLN5 ELN

Biological processes related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet degranulation	GO:0002576	9.58	TGFB2 SERPINA3 CLU
2	transforming growth factor beta receptor signaling pathway	GO:0007179	9.54	TGFB2 LTBP3 LTBP2
3	collagen fibril organization	GO:0030199	9.5	TGFB2 LOXL1 LOX
4	extracellular matrix organization	GO:0030198	9.35	LOXL1 LOX FBN1 FBLN5 ELN
5	peptidyl-lysine oxidation	GO:0018057	9.26	LOXL1 LOX
6	sequestering of TGFbeta in extracellular matrix	GO:0035583	9.16	LTBP1 FBN1
7	elastic fiber assembly	GO:0048251	8.8	LTBP3 LOX FBLN5

Molecular functions related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor binding	GO:0019838	9.43	LTBP3 LTBP2 LTBP1
2	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	GO:0016641	9.37	LOXL1 LOX
3	protein-lysine 6-oxidase activity	GO:0004720	9.32	LOXL1 LOX
4	extracellular matrix structural constituent	GO:0005201	9.26	LTBP2 LTBP1 FBN1 ELN
5	microfibril binding	GO:0050436	9.16	LTBP2 LTBP1
6	extracellular matrix constituent conferring elasticity	GO:0030023	8.8	FBN1 FBLN5 ELN

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Sources for Phacogenic Glaucoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

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¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia