Phacogenic Glaucoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Phacogenic Glaucoma

MalaCards integrated aliases for Phacogenic Glaucoma:

Name: Phacogenic Glaucoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:12571

ICD9CM ³⁴ 365.59

UMLS ⁷¹ C0154959 C0271142

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Summaries for Phacogenic Glaucoma

Disease Ontology : ¹² A glaucoma characterized by glaucomatous optic atrophy secondary to a lens abnormality and has symptom progressive decreased vision, especially decreased peripheral vision. Phacogenic glaucoma can be caused by cataracts, trauma to the eye, or age-related damage that obstructs aqueous outflow, leading to inappropriately increased intraocular pressure and eventual optic nerve atrophy with associated vision loss.

MalaCards based summary : Phacogenic Glaucoma is related to exfoliation syndrome and phacolytic glaucoma, and has symptoms including progressive decreased vision An important gene associated with Phacogenic Glaucoma is LOXL1 (Lysyl Oxidase Like 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. Affiliated tissues include eye, and related phenotype is respiratory system.

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Related Diseases for Phacogenic Glaucoma

Diseases related to Phacogenic Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)

#	Related Disease	Score	Top Affiliating Genes
1	exfoliation syndrome	31.4	TLCD5 SERPINA3 LOXL1-AS1 LOXL1 LOX FBN1
2	phacolytic glaucoma	11.4
3	blepharochalasis	10.5	SERPINA3 ELN
4	cone-rod dystrophy, x-linked, 3	10.5	SERPINA3 CRYAA
5	late-onset focal dermal elastosis	10.5	FBN1 ELN
6	pseudoxanthoma elasticum-like papillary dermal elastolysis	10.5	FBN1 ELN
7	traumatic glaucoma	10.5	MYOC LTBP2
8	chronic actinic dermatitis	10.4	FBN1 ELN
9	familial abdominal aortic aneurysm	10.4	FBN1 ELN
10	mid-dermal elastolysis	10.4	FBN1 ELN
11	glaucoma 1, open angle, a	10.4	OPTN MYOC
12	phimosis	10.4	PEX19 ELN CRYAA
13	aqueous misdirection	10.4	PEX19 LAMA3
14	histiocytic and dendritic cell cancer	10.4	SERPINA3 CLU
15	cutis laxa, autosomal recessive, type ia	10.4	LOXL1 FBN1
16	nanophthalmos	10.4	WDR36 MYOC LOXL1
17	excessive tearing	10.3	WDR36 MYOC LTBP2
18	enophthalmos	10.3	FBN1 CRYAA
19	aniridia 1	10.3	MYOC LTBP2 CRYAA
20	sorsby fundus dystrophy	10.3	FBN1 ELN CRYAA
21	bladder diverticulum	10.3	LOX ELN
22	collagen disease	10.3	SERPINA3 FBN1 ELN
23	mature cataract	10.3	PEX19 LAMA3 CRYAA
24	uveal disease	10.3	SERPINA3 PEX19 LOXL1 CRYAA
25	peripheral retinal degeneration	10.3	WDR36 MYOC
26	tricuspid valve prolapse	10.3	TGFB2 FBN1
27	aortic aneurysm, familial abdominal, 1	10.3	SERPINA3 FBN1 ELN
28	tenosynovial giant cell tumor	10.3	SERPINA3 CLU
29	pulmonary emphysema	10.3	SERPINA3 LOX ELN
30	ureteric orifice cancer	10.3	LOX FBN1 ELN
31	prion disease	10.3	SERPINA3 CRYAA CLU
32	neovascular glaucoma	10.3	TGFB2 PEX19 CRYAA
33	geleophysic dysplasia 3	10.3	LTBP3 LTBP2
34	heart valve disease	10.3	SERPINA3 FBN1 ELN
35	loeys-dietz syndrome 5	10.2	TGFB2 FBN1
36	aortic valve disease 2	10.2	SERPINA3 FBN1 ELN
37	costello syndrome	10.2	LOX FBN1 ELN
38	chromosomal disease	10.2	SERPINA3 ELN CRYAA
39	corneal edema	10.2	MYOC LTBP2 LAMA3
40	cutis laxa, autosomal recessive, type ic	10.2	LTBP3 LTBP2
41	homocysteinemia	10.2	FBN1 ELN CLU
42	morgagni cataract	10.2	PEX19 LOXL1 LAMA3 CRYAA
43	corneal disease	10.2	TGFB2 SERPINA3 CRYAA
44	arterial tortuosity syndrome	10.2	TGFB2 FBN1 ELN
45	autosomal recessive cutis laxa type i	10.2	LTBP3 FBN1 ELN
46	geleophysic dysplasia 1	10.2	LTBP3 LTBP2 FBN1
47	pectus excavatum	10.2	TMCO1 FBN1
48	geleophysic dysplasia 2	10.2	LTBP3 LTBP2 FBN1
49	homocystinuria	10.2	LOX FBN1 CRYAA
50	pelvic organ prolapse	10.1	LOXL1 LOX FBN1 ELN

Graphical network of the top 20 diseases related to Phacogenic Glaucoma:

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Symptoms & Phenotypes for Phacogenic Glaucoma

Symptoms:

¹²

• progressive decreased vision

MGI Mouse Phenotypes related to Phacogenic Glaucoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system	MP:0005388	9.17	FBN1 LAMA3 LOX LOXL1 LTBP2 LTBP3

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Drugs & Therapeutics for Phacogenic Glaucoma

Search Clinical Trials , NIH Clinical Center for Phacogenic Glaucoma

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Genetic Tests for Phacogenic Glaucoma

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Anatomical Context for Phacogenic Glaucoma

MalaCards organs/tissues related to Phacogenic Glaucoma:

⁴⁰

Eye

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Publications for Phacogenic Glaucoma

Articles related to Phacogenic Glaucoma:

#	Title	Authors	PMID	Year
1	[Glaucoma in Marfan syndrome: position-dependent measurement of intraocular pressure as a diagnostic criterium]. ⁶¹	Schlote T...Thiel HJ	8583753	1995

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Genes for Phacogenic Glaucoma

Genes related to Phacogenic Glaucoma (0 elite genes):

(show all 23)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LOXL1	Lysyl Oxidase Like 1	Protein Coding	9.83	DISEASES inferred ¹⁵
2	CRYAA	Crystallin Alpha A	Protein Coding	9.28	DISEASES inferred ¹⁵ ¹⁵
3	PEX19	Peroxisomal Biogenesis Factor 19	Protein Coding	8.48	DISEASES inferred ¹⁵
4	SERPINA3	Serpin Family A Member 3	Protein Coding	7.86	DISEASES inferred ¹⁵ ¹⁵
5	MYOC	Myocilin	Protein Coding	7.5	DISEASES inferred ¹⁵
6	LOXL1-AS1	LOXL1 Antisense RNA 1	RNA Gene	7.25	DISEASES inferred ¹⁵
7	TLCD5	TLC Domain Containing 5	Protein Coding	7.23	DISEASES inferred ¹⁵
8	ELN	Elastin	Protein Coding	7.12	DISEASES inferred ¹⁵
9	WDR36	WD Repeat Domain 36	Protein Coding	7.08	DISEASES inferred ¹⁵
10	LTBP2	Latent Transforming Growth Factor Beta Binding Protein 2	Protein Coding	6.93	DISEASES inferred ¹⁵
11	FBN1	Fibrillin 1	Protein Coding	6.81	DISEASES inferred ¹⁵
12	CLU	Clusterin	Protein Coding	6.64	DISEASES inferred ¹⁵
13	LOX	Lysyl Oxidase	Protein Coding	6.6	DISEASES inferred ¹⁵
14	OPTN	Optineurin	Protein Coding	6.56	DISEASES inferred ¹⁵
15	TMCO1	Transmembrane And Coiled-Coil Domains 1	Protein Coding	6.56	DISEASES inferred ¹⁵
16	LAMA3	Laminin Subunit Alpha 3	Protein Coding	6.35	DISEASES inferred ¹⁵
17	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	6.28	DISEASES inferred ¹⁵
18	LTBP3	Latent Transforming Growth Factor Beta Binding Protein 3	Protein Coding	6.28	DISEASES inferred ¹⁵
19	LTBP1	Latent Transforming Growth Factor Beta Binding Protein 1	Protein Coding	6.13	DISEASES inferred ¹⁵
20	OR11L1	Olfactory Receptor Family 11 Subfamily L Member 1	Protein Coding	6.11	DISEASES inferred ¹⁵
21	FBLN5	Fibulin 5	Protein Coding	6.08	DISEASES inferred ¹⁵
22	NARF	Nuclear Prelamin A Recognition Factor	Protein Coding	6.05	DISEASES inferred ¹⁵
23	LOXL4	Lysyl Oxidase Like 4	Protein Coding	6.05	DISEASES inferred ¹⁵

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Variations for Phacogenic Glaucoma

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Expression for Phacogenic Glaucoma

Search GEO for disease gene expression data for Phacogenic Glaucoma.

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Pathways for Phacogenic Glaucoma

Pathways related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Phospholipase-C Pathway ⁶³ Show member pathways PTEN Pathway ⁶³	12.76	TGFB2 LTBP3 LTBP2 LTBP1 LAMA3 FBN1
2	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.26	TGFB2 LTBP3 LTBP2 LTBP1 LOXL1 LOX
3	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	11.94	TGFB2 LTBP3 LTBP2 LTBP1
4	TGF-beta signaling pathway (KEGG) ³⁶	11.52	TGFB2 LTBP1 FBN1
5	G-protein signaling_RhoA regulation pathway ²²	11.4	TGFB2 LTBP3 LTBP2 LTBP1
6	Elastic fibre formation ⁶⁵ Show member pathways Molecules associated with elastic fibres ⁶⁵	11.09	TGFB2 LTBP3 LTBP2 LTBP1 LOXL1 LOX
7	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease ¹	10.83	LTBP2 LTBP1 FBN1
8	G-protein signaling_Rap2B regulation pathway ²²	10.6	TGFB2 LTBP3 LTBP2 LTBP1 LAMA3 FBN1

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GO Terms for Phacogenic Glaucoma

Cellular components related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.97	TGFB2 SERPINA3 MYOC LTBP2 LOXL1 LOX
2	extracellular region	GO:0005576	9.73	TGFB2 SERPINA3 MYOC LTBP3 LTBP2 LTBP1
3	extracellular matrix	GO:0031012	9.63	LTBP2 LTBP1 LOXL1 LOX FBN1 ELN
4	basement membrane	GO:0005604	9.58	LOXL1 LAMA3 FBN1
5	platelet alpha granule lumen	GO:0031093	9.43	TGFB2 SERPINA3 CLU
6	collagen-containing extracellular matrix	GO:0062023	9.36	TGFB2 SERPINA3 MYOC LTBP3 LTBP2 LTBP1
7	microfibril	GO:0001527	9.32	LTBP1 FBN1

Biological processes related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet degranulation	GO:0002576	9.61	TGFB2 SERPINA3 CLU
2	transforming growth factor beta receptor signaling pathway	GO:0007179	9.58	TGFB2 LTBP3 LTBP2
3	collagen fibril organization	GO:0030199	9.43	TGFB2 LOXL1 LOX
4	elastic fiber assembly	GO:0048251	9.37	LTBP3 LOX
5	extracellular matrix organization	GO:0030198	9.35	LOXL1 LOX LAMA3 FBN1 ELN
6	peptidyl-lysine oxidation	GO:0018057	9.32	LOXL1 LOX
7	sequestering of TGFbeta in extracellular matrix	GO:0035583	9.16	LTBP1 FBN1
8	aorta development	GO:0035904	8.8	LTBP1 LOXL1 LOX

Molecular functions related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor binding	GO:0019838	9.5	LTBP3 LTBP2 LTBP1
2	extracellular matrix constituent conferring elasticity	GO:0030023	9.37	FBN1 ELN
3	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	GO:0016641	9.26	LOXL1 LOX
4	protein-lysine 6-oxidase activity	GO:0004720	9.16	LOXL1 LOX
5	extracellular matrix structural constituent	GO:0005201	9.02	LTBP2 LTBP1 LAMA3 FBN1 ELN
6	microfibril binding	GO:0050436	8.96	LTBP2 LTBP1

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Sources for Phacogenic Glaucoma

¹ BioSystems

² BitterDB

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⁴ Cell Signaling Technology

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²⁰ GeneAnalytics

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²⁵ Genetics Home Reference

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²⁷ GEO DataSets

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³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

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⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁴⁹ NCIt

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⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

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⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia