Phacogenic Glaucoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Phacogenic Glaucoma

MalaCards integrated aliases for Phacogenic Glaucoma:

Name: Phacogenic Glaucoma ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:12571

ICD9CM ³⁵ 365.59

SNOMED-CT ⁶⁸ 84333006

UMLS ⁷³ C0154959 C0271142

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Summaries for Phacogenic Glaucoma

MalaCards based summary : Phacogenic Glaucoma is related to morgagni cataract and phimosis. An important gene associated with Phacogenic Glaucoma is LOXL1 (Lysyl Oxidase Like 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include eye, and related phenotypes are hearing/vestibular/ear and respiratory system

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Related Diseases for Phacogenic Glaucoma

Diseases related to Phacogenic Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)

#	Related Disease	Score	Top Affiliating Genes
1	morgagni cataract	10.6	CRYAA PHEX
2	phimosis	10.6	ELN PEX19
3	tricuspid valve prolapse	10.4	FBN1 PHEX
4	pseudoxanthoma elasticum-like papillary dermal elastolysis	10.4	ELN FBN1
5	late-onset focal dermal elastosis	10.4	ELN FBN1
6	familial abdominal aortic aneurysm	10.4	ELN FBN1
7	chronic actinic dermatitis	10.3	ELN FBN1
8	traumatic glaucoma	10.3	OPTN PHEX
9	mid-dermal elastolysis	10.3	ELN FBN1
10	chronic closed-angle glaucoma	10.3	OPTN PHEX
11	glaucoma, normal tension	10.3	LOXL1 OPTN
12	intraocular pressure quantitative trait locus	10.3	LOXL1 OPTN
13	acute closed-angle glaucoma	10.3	OPTN PEX19
14	aortic valve insufficiency	10.3	ELN FBN1
15	sorsby fundus dystrophy	10.3	ELN FBN1
16	supravalvular aortic stenosis	10.2	ELN FBN1
17	blood group, globoside system	10.2	CRYAA OPTN
18	vernal conjunctivitis	10.1	LOXL1 OPTN
19	aortic aneurysm, familial thoracic 1	10.1	ELN FBN1
20	pneumothorax	10.1	ELN FBN1
21	hydrophthalmos	10.0	LTBP2 OPTN
22	excessive tearing	10.0	LTBP2 OPTN
23	weill-marchesani syndrome	10.0	FBN1 LTBP2
24	megalocornea	10.0	LTBP2 OPTN
25	collagen disease	10.0	ELN FBN1
26	corneal edema	9.9	LTBP2 OPTN
27	juvenile glaucoma	9.9	ELN OPTN PHEX
28	primary congenital glaucoma	9.9	LTBP2 OPTN
29	aortic valve disease 1	9.9	ELN FBN1
30	glaucoma 3, primary congenital, a	9.8	LTBP2 OPTN
31	marfan syndrome	9.8	ELN FBN1 LTBP2
32	pelvic organ prolapse	9.7	ELN LOX LOXL1
33	menkes disease	9.7	ELN LOX
34	glaucoma, primary open angle	9.6	ELN LOXL1 OPTN PHEX
35	lens disease	9.6	CRYAA OPTN PEX19 PHEX
36	optic nerve neoplasm	9.6	LOX OPTN
37	aortic disease	9.5	ELN FBN1
38	optic nerve glioma	9.5	LOX OPTN
39	trehalase deficiency	9.4	CRYAA ELN FBN1 PEX19
40	intracranial aneurysm	9.4	ELN LOX
41	aneurysm	9.4	ELN FBN1 LOX
42	aortic aneurysm	9.4	ELN FBN1 LOX
43	open-angle glaucoma	9.3	ELN LOXL1 LTBP2 OPTN
44	iris disease	9.2	CRYAA LOXL1 OPTN PEX19 PHEX
45	exfoliation syndrome	8.1	CLU ELN FBN1 LOX LOXL1 LYST

Graphical network of the top 20 diseases related to Phacogenic Glaucoma:

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Symptoms & Phenotypes for Phacogenic Glaucoma

MGI Mouse Phenotypes related to Phacogenic Glaucoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear	MP:0005377	9.26	LOXL1 LTBP2 LYST PHEX
2	respiratory system	MP:0005388	9.02	FBN1 LOX LOXL1 LTBP2 LYST

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Drugs & Therapeutics for Phacogenic Glaucoma

Search Clinical Trials , NIH Clinical Center for Phacogenic Glaucoma

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Genetic Tests for Phacogenic Glaucoma

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Anatomical Context for Phacogenic Glaucoma

MalaCards organs/tissues related to Phacogenic Glaucoma:

⁴¹

Eye

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Publications for Phacogenic Glaucoma

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Genes for Phacogenic Glaucoma

Genes related to Phacogenic Glaucoma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LOXL1	Lysyl Oxidase Like 1	Protein Coding	19.58	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	PHEX	Phosphate Regulating Endopeptidase Homolog X-Linked	Protein Coding	19.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PEX19	Peroxisomal Biogenesis Factor 19	Protein Coding	18.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	CRYAA	Crystallin Alpha A	Protein Coding	16.1	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	ELN	Elastin	Protein Coding	15.96	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	CLU	Clusterin	Protein Coding	15.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	LYST	Lysosomal Trafficking Regulator	Protein Coding	15.83	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	FBN1	Fibrillin 1	Protein Coding	15.69	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	OPTN	Optineurin	Protein Coding	15.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	LOX	Lysyl Oxidase	Protein Coding	15.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	LTBP2	Latent Transforming Growth Factor Beta Binding Protein 2	Protein Coding	15.24	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Phacogenic Glaucoma

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Expression for Phacogenic Glaucoma

Search GEO for disease gene expression data for Phacogenic Glaucoma.

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Pathways for Phacogenic Glaucoma

Pathways related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁶ Show member pathways Collagen degradation ⁶⁶ Extracellular matrix organization ⁶⁶	12.01	ELN FBN1 LOX LOXL1 LTBP2
2	Elastic fibre formation ⁶⁶ Show member pathways Molecules associated with elastic fibres ⁶⁶	10.88	ELN FBN1 LOX LOXL1 LTBP2
3	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease ¹	10.55	FBN1 LTBP2

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GO Terms for Phacogenic Glaucoma

Cellular components related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.43	CLU ELN FBN1 LOX LOXL1 LTBP2
2	extracellular matrix	GO:0031012	9.02	CLU ELN FBN1 LOXL1 LTBP2

Biological processes related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein stabilization	GO:0050821	9.43	CLU CRYAA PEX19
2	blood vessel development	GO:0001568	9.4	LOX LOXL1
3	chaperone-mediated protein folding	GO:0061077	9.37	CLU PEX19
4	collagen fibril organization	GO:0030199	9.32	LOX LOXL1
5	aorta development	GO:0035904	9.16	LOX LOXL1
6	elastic fiber assembly	GO:0048251	8.96	LOX LOXL1
7	extracellular matrix organization	GO:0030198	8.92	ELN FBN1 LOX LOXL1

Molecular functions related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	copper ion binding	GO:0005507	9.16	LOX LOXL1
2	protein-lysine 6-oxidase activity	GO:0004720	8.96	LOX LOXL1
3	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	GO:0016641	8.62	LOX LOXL1

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Sources for Phacogenic Glaucoma

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²⁰ GeneAnalytics

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³⁶ IUPHAR

³⁷ KEGG

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⁴¹ MalaCards

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⁴⁸ NCBI Bookshelf

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⁶⁸ SNOMED-CT

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

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⁷⁶ Wikipedia