MCID: PHC002
MIFTS: 25

Phacogenic Glaucoma

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Phacogenic Glaucoma

MalaCards integrated aliases for Phacogenic Glaucoma:

Name: Phacogenic Glaucoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12571
ICD9CM 34 365.59
UMLS 71 C0154959 C0271142

Summaries for Phacogenic Glaucoma

Disease Ontology : 12 A glaucoma characterized by glaucomatous optic atrophy secondary to a lens abnormality and has symptom progressive decreased vision, especially decreased peripheral vision. Phacogenic glaucoma can be caused by cataracts, trauma to the eye, or age-related damage that obstructs aqueous outflow, leading to inappropriately increased intraocular pressure and eventual optic nerve atrophy with associated vision loss.

MalaCards based summary : Phacogenic Glaucoma is related to exfoliation syndrome and phacolytic glaucoma, and has symptoms including progressive decreased vision An important gene associated with Phacogenic Glaucoma is LOXL1 (Lysyl Oxidase Like 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. Affiliated tissues include eye, and related phenotype is respiratory system.

Related Diseases for Phacogenic Glaucoma

Diseases related to Phacogenic Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 exfoliation syndrome 31.4 TLCD5 SERPINA3 LOXL1-AS1 LOXL1 LOX FBN1
2 phacolytic glaucoma 11.4
3 blepharochalasis 10.5 SERPINA3 ELN
4 cone-rod dystrophy, x-linked, 3 10.5 SERPINA3 CRYAA
5 late-onset focal dermal elastosis 10.5 FBN1 ELN
6 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.5 FBN1 ELN
7 traumatic glaucoma 10.5 MYOC LTBP2
8 chronic actinic dermatitis 10.4 FBN1 ELN
9 familial abdominal aortic aneurysm 10.4 FBN1 ELN
10 mid-dermal elastolysis 10.4 FBN1 ELN
11 glaucoma 1, open angle, a 10.4 OPTN MYOC
12 phimosis 10.4 PEX19 ELN CRYAA
13 aqueous misdirection 10.4 PEX19 LAMA3
14 histiocytic and dendritic cell cancer 10.4 SERPINA3 CLU
15 cutis laxa, autosomal recessive, type ia 10.4 LOXL1 FBN1
16 nanophthalmos 10.4 WDR36 MYOC LOXL1
17 excessive tearing 10.3 WDR36 MYOC LTBP2
18 enophthalmos 10.3 FBN1 CRYAA
19 aniridia 1 10.3 MYOC LTBP2 CRYAA
20 sorsby fundus dystrophy 10.3 FBN1 ELN CRYAA
21 bladder diverticulum 10.3 LOX ELN
22 collagen disease 10.3 SERPINA3 FBN1 ELN
23 mature cataract 10.3 PEX19 LAMA3 CRYAA
24 uveal disease 10.3 SERPINA3 PEX19 LOXL1 CRYAA
25 peripheral retinal degeneration 10.3 WDR36 MYOC
26 tricuspid valve prolapse 10.3 TGFB2 FBN1
27 aortic aneurysm, familial abdominal, 1 10.3 SERPINA3 FBN1 ELN
28 tenosynovial giant cell tumor 10.3 SERPINA3 CLU
29 pulmonary emphysema 10.3 SERPINA3 LOX ELN
30 ureteric orifice cancer 10.3 LOX FBN1 ELN
31 prion disease 10.3 SERPINA3 CRYAA CLU
32 neovascular glaucoma 10.3 TGFB2 PEX19 CRYAA
33 geleophysic dysplasia 3 10.3 LTBP3 LTBP2
34 heart valve disease 10.3 SERPINA3 FBN1 ELN
35 loeys-dietz syndrome 5 10.2 TGFB2 FBN1
36 aortic valve disease 2 10.2 SERPINA3 FBN1 ELN
37 costello syndrome 10.2 LOX FBN1 ELN
38 chromosomal disease 10.2 SERPINA3 ELN CRYAA
39 corneal edema 10.2 MYOC LTBP2 LAMA3
40 cutis laxa, autosomal recessive, type ic 10.2 LTBP3 LTBP2
41 homocysteinemia 10.2 FBN1 ELN CLU
42 morgagni cataract 10.2 PEX19 LOXL1 LAMA3 CRYAA
43 corneal disease 10.2 TGFB2 SERPINA3 CRYAA
44 arterial tortuosity syndrome 10.2 TGFB2 FBN1 ELN
45 autosomal recessive cutis laxa type i 10.2 LTBP3 FBN1 ELN
46 geleophysic dysplasia 1 10.2 LTBP3 LTBP2 FBN1
47 pectus excavatum 10.2 TMCO1 FBN1
48 geleophysic dysplasia 2 10.2 LTBP3 LTBP2 FBN1
49 homocystinuria 10.2 LOX FBN1 CRYAA
50 pelvic organ prolapse 10.1 LOXL1 LOX FBN1 ELN

Graphical network of the top 20 diseases related to Phacogenic Glaucoma:



Diseases related to Phacogenic Glaucoma

Symptoms & Phenotypes for Phacogenic Glaucoma

Symptoms:

12
  • progressive decreased vision

MGI Mouse Phenotypes related to Phacogenic Glaucoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.17 FBN1 LAMA3 LOX LOXL1 LTBP2 LTBP3

Drugs & Therapeutics for Phacogenic Glaucoma

Search Clinical Trials , NIH Clinical Center for Phacogenic Glaucoma

Genetic Tests for Phacogenic Glaucoma

Anatomical Context for Phacogenic Glaucoma

MalaCards organs/tissues related to Phacogenic Glaucoma:

40
Eye

Publications for Phacogenic Glaucoma

Articles related to Phacogenic Glaucoma:

# Title Authors PMID Year
1
[Glaucoma in Marfan syndrome: position-dependent measurement of intraocular pressure as a diagnostic criterium]. 61
8583753 1995

Variations for Phacogenic Glaucoma

Expression for Phacogenic Glaucoma

Search GEO for disease gene expression data for Phacogenic Glaucoma.

Pathways for Phacogenic Glaucoma

GO Terms for Phacogenic Glaucoma

Cellular components related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 TGFB2 SERPINA3 MYOC LTBP2 LOXL1 LOX
2 extracellular region GO:0005576 9.73 TGFB2 SERPINA3 MYOC LTBP3 LTBP2 LTBP1
3 extracellular matrix GO:0031012 9.63 LTBP2 LTBP1 LOXL1 LOX FBN1 ELN
4 basement membrane GO:0005604 9.58 LOXL1 LAMA3 FBN1
5 platelet alpha granule lumen GO:0031093 9.43 TGFB2 SERPINA3 CLU
6 collagen-containing extracellular matrix GO:0062023 9.36 TGFB2 SERPINA3 MYOC LTBP3 LTBP2 LTBP1
7 microfibril GO:0001527 9.32 LTBP1 FBN1

Biological processes related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.61 TGFB2 SERPINA3 CLU
2 transforming growth factor beta receptor signaling pathway GO:0007179 9.58 TGFB2 LTBP3 LTBP2
3 collagen fibril organization GO:0030199 9.43 TGFB2 LOXL1 LOX
4 elastic fiber assembly GO:0048251 9.37 LTBP3 LOX
5 extracellular matrix organization GO:0030198 9.35 LOXL1 LOX LAMA3 FBN1 ELN
6 peptidyl-lysine oxidation GO:0018057 9.32 LOXL1 LOX
7 sequestering of TGFbeta in extracellular matrix GO:0035583 9.16 LTBP1 FBN1
8 aorta development GO:0035904 8.8 LTBP1 LOXL1 LOX

Molecular functions related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 9.5 LTBP3 LTBP2 LTBP1
2 extracellular matrix constituent conferring elasticity GO:0030023 9.37 FBN1 ELN
3 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 9.26 LOXL1 LOX
4 protein-lysine 6-oxidase activity GO:0004720 9.16 LOXL1 LOX
5 extracellular matrix structural constituent GO:0005201 9.02 LTBP2 LTBP1 LAMA3 FBN1 ELN
6 microfibril binding GO:0050436 8.96 LTBP2 LTBP1

Sources for Phacogenic Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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