MCID: PHC002
MIFTS: 22

Phacogenic Glaucoma

Categories: Eye diseases

Aliases & Classifications for Phacogenic Glaucoma

MalaCards integrated aliases for Phacogenic Glaucoma:

Name: Phacogenic Glaucoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12571
ICD9CM 35 365.59
SNOMED-CT 68 84333006

Summaries for Phacogenic Glaucoma

MalaCards based summary : Phacogenic Glaucoma is related to morgagni cataract and phimosis. An important gene associated with Phacogenic Glaucoma is LOXL1 (Lysyl Oxidase Like 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include eye, and related phenotypes are hearing/vestibular/ear and respiratory system

Related Diseases for Phacogenic Glaucoma

Diseases related to Phacogenic Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 morgagni cataract 10.6 CRYAA PHEX
2 phimosis 10.6 ELN PEX19
3 tricuspid valve prolapse 10.4 FBN1 PHEX
4 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.4 ELN FBN1
5 late-onset focal dermal elastosis 10.4 ELN FBN1
6 familial abdominal aortic aneurysm 10.4 ELN FBN1
7 chronic actinic dermatitis 10.3 ELN FBN1
8 traumatic glaucoma 10.3 OPTN PHEX
9 mid-dermal elastolysis 10.3 ELN FBN1
10 chronic closed-angle glaucoma 10.3 OPTN PHEX
11 glaucoma, normal tension 10.3 LOXL1 OPTN
12 intraocular pressure quantitative trait locus 10.3 LOXL1 OPTN
13 acute closed-angle glaucoma 10.3 OPTN PEX19
14 aortic valve insufficiency 10.3 ELN FBN1
15 sorsby fundus dystrophy 10.3 ELN FBN1
16 supravalvular aortic stenosis 10.2 ELN FBN1
17 blood group, globoside system 10.2 CRYAA OPTN
18 vernal conjunctivitis 10.1 LOXL1 OPTN
19 aortic aneurysm, familial thoracic 1 10.1 ELN FBN1
20 pneumothorax 10.1 ELN FBN1
21 hydrophthalmos 10.0 LTBP2 OPTN
22 excessive tearing 10.0 LTBP2 OPTN
23 weill-marchesani syndrome 10.0 FBN1 LTBP2
24 megalocornea 10.0 LTBP2 OPTN
25 collagen disease 10.0 ELN FBN1
26 corneal edema 9.9 LTBP2 OPTN
27 juvenile glaucoma 9.9 ELN OPTN PHEX
28 primary congenital glaucoma 9.9 LTBP2 OPTN
29 aortic valve disease 1 9.9 ELN FBN1
30 glaucoma 3, primary congenital, a 9.8 LTBP2 OPTN
31 marfan syndrome 9.8 ELN FBN1 LTBP2
32 pelvic organ prolapse 9.7 ELN LOX LOXL1
33 menkes disease 9.7 ELN LOX
34 glaucoma, primary open angle 9.6 ELN LOXL1 OPTN PHEX
35 lens disease 9.6 CRYAA OPTN PEX19 PHEX
36 optic nerve neoplasm 9.6 LOX OPTN
37 aortic disease 9.5 ELN FBN1
38 optic nerve glioma 9.5 LOX OPTN
39 trehalase deficiency 9.4 CRYAA ELN FBN1 PEX19
40 intracranial aneurysm 9.4 ELN LOX
41 aneurysm 9.4 ELN FBN1 LOX
42 aortic aneurysm 9.4 ELN FBN1 LOX
43 open-angle glaucoma 9.3 ELN LOXL1 LTBP2 OPTN
44 iris disease 9.2 CRYAA LOXL1 OPTN PEX19 PHEX
45 exfoliation syndrome 8.1 CLU ELN FBN1 LOX LOXL1 LYST

Graphical network of the top 20 diseases related to Phacogenic Glaucoma:



Diseases related to Phacogenic Glaucoma

Symptoms & Phenotypes for Phacogenic Glaucoma

MGI Mouse Phenotypes related to Phacogenic Glaucoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.26 LOXL1 LTBP2 LYST PHEX
2 respiratory system MP:0005388 9.02 FBN1 LOX LOXL1 LTBP2 LYST

Drugs & Therapeutics for Phacogenic Glaucoma

Search Clinical Trials , NIH Clinical Center for Phacogenic Glaucoma

Genetic Tests for Phacogenic Glaucoma

Anatomical Context for Phacogenic Glaucoma

MalaCards organs/tissues related to Phacogenic Glaucoma:

41
Eye

Publications for Phacogenic Glaucoma

Variations for Phacogenic Glaucoma

Expression for Phacogenic Glaucoma

Search GEO for disease gene expression data for Phacogenic Glaucoma.

Pathways for Phacogenic Glaucoma

Pathways related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 ELN FBN1 LOX LOXL1 LTBP2
2
Show member pathways
10.88 ELN FBN1 LOX LOXL1 LTBP2
3 10.55 FBN1 LTBP2

GO Terms for Phacogenic Glaucoma

Cellular components related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CLU ELN FBN1 LOX LOXL1 LTBP2
2 extracellular matrix GO:0031012 9.02 CLU ELN FBN1 LOXL1 LTBP2

Biological processes related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 9.43 CLU CRYAA PEX19
2 blood vessel development GO:0001568 9.4 LOX LOXL1
3 chaperone-mediated protein folding GO:0061077 9.37 CLU PEX19
4 collagen fibril organization GO:0030199 9.32 LOX LOXL1
5 aorta development GO:0035904 9.16 LOX LOXL1
6 elastic fiber assembly GO:0048251 8.96 LOX LOXL1
7 extracellular matrix organization GO:0030198 8.92 ELN FBN1 LOX LOXL1

Molecular functions related to Phacogenic Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.16 LOX LOXL1
2 protein-lysine 6-oxidase activity GO:0004720 8.96 LOX LOXL1
3 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 8.62 LOX LOXL1

Sources for Phacogenic Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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