MCID: PHH001
MIFTS: 42

Phaeohyphomycosis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Phaeohyphomycosis

MalaCards integrated aliases for Phaeohyphomycosis:

Name: Phaeohyphomycosis 12 52 43 15 71
Infection by Dematiacious Fungi 12
Phaehyphomycosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14049
MeSH 43 D060446
UMLS 71 C0276721

Summaries for Phaeohyphomycosis

Disease Ontology : 12 A primary systemic mycosis located in subcutaneous tissues, located in brain, located in sinuses, located in lungs, or located in peritoneal cavity, has material basis in Exophiala dermatitidis, has material basis in Phialophora, has material basis in Bipolaris hawaiiensis, has material basis in Exserohilum, has material basis in Cladophialophora bantiana, has material basis in Phaeoannellomyces, has material basis in Aureobasidium, has material basis in Cladosporium cladosporoides, has material basis in Alternaria or has material basis in Rhinocladiella mackenziei and results in formation of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals.

MalaCards based summary : Phaeohyphomycosis, also known as infection by dematiacious fungi, is related to tinea nigra and mucormycosis. An important gene associated with Phaeohyphomycosis is CARD9 (Caspase Recruitment Domain Family Member 9), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and Tuberculosis. The drugs Miconazole and Posaconazole have been mentioned in the context of this disorder. Affiliated tissues include subcutaneous tissues, brain and sinuses, and related phenotypes are hematopoietic system and immune system

NIH Rare Diseases : 52 Phaeohyphomycosis refers to fungal infections caused by dematiaceous (darkly pigmented) fungi. It can be associated with a variety of clinical syndromes including invasive sinusitis ; nodules or abscesses beneath the skin; keratitis ; lung masses; osteomyelitis ; mycotic arthritis ; endocarditis ; brain abscess; and wide-spread infection. Although the condition can affect anyone, it is most commonly diagnosed in people with suppressed immune systems (like those who have undergone an organ transplant) and can even be life-threatening in these populations. Treatment depends on the signs and symptoms present in each person but may include surgery and/or various antifungal medications.

Wikipedia : 74 Phaeohyphomycosis is a heterogeneous group of mycotic infections caused by dematiaceous fungi whose... more...

Related Diseases for Phaeohyphomycosis

Diseases related to Phaeohyphomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 tinea nigra 32.8 POLR2B CBSL
2 mucormycosis 30.2 CLEC7A CARD9 B4GALNT2
3 corneal ulcer 30.2 CLEC7A CLEC6A
4 fungal keratitis 29.9 CLEC7A CLEC4E
5 otitis externa 29.9 POLR2B CBSL B4GALNT2
6 eumycotic mycetoma 29.9 TUB POLR2B CBSL
7 sporotrichosis 29.9 CLEC7A CBSL CARD9
8 cryptococcosis 29.8 CLEC7A CLEC6A CLEC4D
9 superficial mycosis 29.8 CLEC7A CLEC6A CBSL B4GALNT2
10 chromoblastomycosis 29.6 CLEC7A CLEC6A CLEC4E CLEC4D CBSL CARD9
11 invasive aspergillosis 29.6 CLEC7A CLEC6A
12 opportunistic mycosis 29.3 CLEC7A CLEC6A CLEC4E CARD9 B4GALNT2
13 blastomycosis 28.8 CLEC7A CLEC6A CLEC4E CLEC4D CARD9
14 dermatophytosis 28.2 POLR2B CLEC7A CLEC6A CLEC4E CLEC4D CBSL
15 subcutaneous mycosis 27.9 POLR2B CLEC7A CLEC6A CLEC4E CLEC4D CBSL
16 mycetoma 10.4
17 white piedra 10.3 CBSL B4GALNT2
18 tinea manuum 10.3 CBSL B4GALNT2
19 posttransplant acute limbic encephalitis 10.3
20 conidiobolomycosis 10.3 CBSL B4GALNT2
21 neuroaspergillosis 10.2 CLEC7A CARD9
22 aspergillosis 10.2
23 vasculitis 10.2
24 hyper ige recurrent infection syndrome 1 10.2 CLEC7A CARD9
25 tinea unguium 10.2 CBSL CARD9 B4GALNT2
26 osteomyelitis 10.2
27 tinea capitis 10.1 CBSL CARD9 B4GALNT2
28 common wart 10.1 CLEC6A CLEC4E
29 external ear disease 10.1 POLR2B CBSL B4GALNT2
30 keratitis, hereditary 10.1
31 systemic lupus erythematosus 10.1
32 sarcoidosis 1 10.1
33 meningoencephalitis 10.1
34 neutropenia 10.1
35 nocardiosis 10.1
36 central nervous system disease 10.1
37 nervous system disease 10.1
38 hypereosinophilic syndrome 10.1
39 cutaneous candidiasis 10.1 CLEC7A CARD9 B4GALNT2
40 pneumocystosis 10.1 CLEC7A CLEC6A
41 trichosporonosis 10.1 CLEC7A CBSL B4GALNT2
42 penicilliosis 10.1 POLR2B CLEC7A CARD9
43 autoimmune polyendocrine syndrome type 1 10.1 CLEC7A CARD9
44 leprosy 3 10.1
45 lymphocytic leukemia 10.1
46 respiratory failure 10.1
47 panniculitis 10.1
48 thrombocytopenia 10.1
49 lymphadenitis 10.1
50 rhinitis 10.1

Graphical network of the top 20 diseases related to Phaeohyphomycosis:



Diseases related to Phaeohyphomycosis

Symptoms & Phenotypes for Phaeohyphomycosis

MGI Mouse Phenotypes related to Phaeohyphomycosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 B4GALNT2 BCL10 CARD9 CBSL CLEC4D CLEC4E
2 immune system MP:0005387 9.32 B4GALNT2 BCL10 CARD9 CBSL CLEC4D CLEC4E

Drugs & Therapeutics for Phaeohyphomycosis

Drugs for Phaeohyphomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
2
Posaconazole Approved, Investigational, Vet_approved Phase 3 171228-49-2 147912
3 Anti-Infective Agents Phase 3
4 Cytochrome P-450 Enzyme Inhibitors Phase 3
5 Hormone Antagonists Phase 3
6 Antifungal Agents Phase 3
7 Steroid Synthesis Inhibitors Phase 3
8 Hormones Phase 3
9 Antiparasitic Agents Phase 3
10 Antiprotozoal Agents Phase 3
11 Cytochrome P-450 CYP3A Inhibitors
12 Cytochrome P-450 CYP2C9 Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open Label, Treatment Protocol for the Safety and Efficacy of Posaconazole (SCH 56592) in the Treatment of Invasive Fungal Infections Completed NCT00034632 Phase 3 Posaconazole oral suspension
2 A Retrospective Study to Establish an Historical Database on the Efficacy of Standard Antifungal Therapy in Patients With Invasive Fungal Infections Completed NCT00230243

Search NIH Clinical Center for Phaeohyphomycosis

Cochrane evidence based reviews: phaeohyphomycosis

Genetic Tests for Phaeohyphomycosis

Anatomical Context for Phaeohyphomycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Phaeohyphomycosis:

19
Subcutaneous Tissues, Brain, Sinuses, Lungs, Peritoneal Cavity

MalaCards organs/tissues related to Phaeohyphomycosis:

40
Brain, Lung, Skin, Kidney, Liver, Myeloid, Heart

Publications for Phaeohyphomycosis

Articles related to Phaeohyphomycosis:

(show top 50) (show all 781)
# Title Authors PMID Year
1
Cutaneous phaeohyphomycosis. 61 52
28295266 2017
2
Phaeohyphomycosis. 61 52
16984871 2006
3
Cerebral phaeohyphomycosis caused by Alternaria spp.: A case report. 61
31879586 2020
4
Feline disseminated cutaneous phaeohyphomycosis due to Exophiala spinifera. 61
31908910 2020
5
Cutaneous phaeohyphomycosis caused by Exophiala xenobiotica: A case report. 61
31908912 2020
6
Phaeohyphomycosis. 61
32000289 2020
7
Cladophialophora encephalitis in an alpaca. 61
32020931 2020
8
Phoma (Peyronellaea) spp.: a phytopathogen as a cause of cystic phaeohyphomycosis in a diabetic patient. 61
31445210 2020
9
Polyphasic identification of three new species in Alternaria section Infectoriae causing human cutaneous infection. 61
31651065 2020
10
Recurrent Phaeohyphomycosis due to Phaeoacremonium alvesii Identified with Internal Transcribed Spacer and Beta-tubulin Gene Sequencing. 61
31930424 2020
11
Subcutaneous phaeohyphomycosis caused by Pleurostomophora richardsiae in a renal transplant recipient. 61
31909144 2020
12
Mycetoma-like phaeohyphomycosis treated with terbinafine. 61
32025492 2020
13
Subcutaneous cystic phaeohyphomycosis caused by Exophiala jeanselmei. 61
31392764 2019
14
Subcutaneous phaeohyphomycosis from Medicopsis romeroi in a diabetic patient. 61
31890487 2019
15
Disseminated phaeohyphomycosis by Exophiala jeanselmei. 61
31803917 2019
16
[Phaeohyphomycosis by Exserohilum rostratum in a pediatric patient with acute lymphoblastic leukemia after bone marrow transplantation]. 61
31870615 2019
17
Successful treatment with isavuconazole of subcutaneous phaeohyphomycosis in a kidney transplant recipient. 61
31617282 2019
18
Cerebral phaeohyphomycosis due to Cladophialophora bantiana in a French Guianese child. 61
31926829 2019
19
Phaeohyphomycosis due to Exophiala spinifera greatly improved by ALA-PDT: A case report. 61
31606515 2019
20
Cutaneous phaeohyphomycosis caused by Alternaria alternata in an immunosuppressed patient. 61
31432527 2019
21
Exophiala dermatitidis: Key issues of an opportunistic fungal pathogen. 61
30887863 2019
22
Primary immunodeficiencies and invasive fungal infection: when to suspect and how to diagnose and manage. 61
31567735 2019
23
Phaeohyphomycotic Rhinitis Caused by Bipolaris hawaiiensis in a Horse. 61
31732112 2019
24
Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis. 61
31427294 2019
25
Cutaneous phaeohyphomycosis caused by Pyrenochaeta unguis-hominis in a diabetic patient: A case report. 61
31724160 2019
26
Comparative in vitro pharmacodynamic analysis of isavuconazole, voriconazole, and posaconazole against clinical isolates of aspergillosis, mucormycosis, fusariosis, and phaeohyphomycosis. 61
31427139 2019
27
Phaeohyphomycosis caused by Rhytidhysteron rufulum. 61
31696561 2019
28
Disseminated Phaeohyphomycosis by Exophiala jeanselmei. 61
31711223 2019
29
Cauliflower Ear: A Rare Manifestation of Phaeohyphomycosis. 61
31896852 2019
30
Pigmented Corneal Ulcer. 61
31875106 2019
31
Phaeohyphomycosis caused by Phialophora americana with CARD9 mutation and 20-year literature review in China. 61
31271673 2019
32
The Phytopathogenic Fungus Pallidocercospora crystallina-Caused Localized Subcutaneous Phaeohyphomycosis in a Patient with a Homozygous Missense CARD9 Mutation. 61
31414217 2019
33
Long-Term Carriage of Medicopsis romeroi, an Agent of Black-Grain Mycetoma, Presenting as Phaeohyphomycosis in a Renal Transplant Patient. 61
31502092 2019
34
Following the Track to an Unexpected Diagnosis: Phaeohyphomycosis. 61
30986396 2019
35
Parathyridaria percutanea and Subcutaneous Phaeohyphomycosis. 61
31441754 2019
36
Liquid-based cytology of pigmented phaeohyphomycotic lesion of the palm masquerading as a metastatic tumor. 61
31009173 2019
37
Experimental Infection of Mice with Veronaea botryosa as a Model for Human Phaeohyphomycosis. 61
31387667 2019
38
Feline Phaeohyphomycotic Cerebellitis Caused by Cladosporium cladosporioides-complex: Case Report and Review of Literature. 61
31375163 2019
39
Subcutaneous phaeohyphomycosis due to Cladophialophora bantiana: a first case report in an immunocompetent patient in Latin America and a brief literature review. 61
31340356 2019
40
Mycotic Rhinitis and Sinusitis in Florida Horses. 61
30558508 2019
41
Sticks and bones: Traumatic phaeohyphomycosis presenting as an epidural scalp abscess and cranial osteomyelitis. 61
31080712 2019
42
Disseminated phaeohyphomycosis with hepatic artery and portal vein thrombosis caused by Pleurostomophora richardsiae in a liver transplant recipient: A case report. 61
30868691 2019
43
Subcutaneous phaeohyphomycosis caused by Amesia atrobrunnea in Kuwait. 61
30446389 2019
44
Phaeohyphomycosis caused by Medicopsis romeroi in solid organ transplant recipients: Report of two cases and comprehensive review of the literature. 61
30865352 2019
45
A black mould death: A case of fatal cerebral phaeohyphomycosis caused by Cladophialophora bantiana. 61
30886820 2019
46
Phaeohyphomycosis Due to Exophiala oligosperma in an Immunocompromised Host. 61
31154445 2019
47
Enigma portal case: Phaeohyphomycosis by fine needle aspiration. 61
30554449 2019
48
Cutaneous phaeohyphomycosis caused by Microsphaeropsis arundinis in a Japanese patient with cardiac sarcoidosis. 61
30320462 2019
49
Cutaneous infection by Phaeoacremonium parasiticum. 61
30853370 2019
50
Cerebral Phaeohyphomycosis with Onychomycosis: Case Report and Review of Literature. 61
31143287 2019

Variations for Phaeohyphomycosis

Expression for Phaeohyphomycosis

Search GEO for disease gene expression data for Phaeohyphomycosis.

Pathways for Phaeohyphomycosis

GO Terms for Phaeohyphomycosis

Biological processes related to Phaeohyphomycosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.65 CLEC6A CARD9 BCL10
2 immune system process GO:0002376 9.63 CLEC7A CLEC6A CLEC4E CLEC4D CARD9 BCL10
3 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.54 CLEC7A CARD9 BCL10
4 T cell activation GO:0042110 9.52 SLA2 CLEC7A
5 positive regulation of phagocytosis GO:0050766 9.51 TUB CLEC7A
6 positive regulation of cytokine secretion GO:0050715 9.49 CLEC6A CLEC4E
7 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.46 CLEC7A BCL10
8 pattern recognition receptor signaling pathway GO:0002221 9.43 CLEC7A CLEC4E
9 innate immune response GO:0045087 9.43 CLEC7A CLEC6A CLEC4E CLEC4D CARD9 BCL10
10 response to fungus GO:0009620 9.4 CARD9 BCL10
11 Fc-gamma receptor signaling pathway GO:0038094 9.32 CLEC4E CLEC4D
12 T cell differentiation involved in immune response GO:0002292 9.26 CLEC4E CLEC4D
13 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 CLEC6A CLEC4E CLEC4D CARD9 BCL10

Molecular functions related to Phaeohyphomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CARD domain binding GO:0050700 8.96 CARD9 BCL10
2 carbohydrate binding GO:0030246 8.92 CLEC7A CLEC6A CLEC4E CLEC4D

Sources for Phaeohyphomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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