MCID: PHH001
MIFTS: 49

Phaeohyphomycosis

Categories: Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Phaeohyphomycosis

MalaCards integrated aliases for Phaeohyphomycosis:

Name: Phaeohyphomycosis 12 53 44 15 73
Infection by Dematiacious Fungi 12
Phaehyphomycosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14049
MeSH 44 D060446
UMLS 73 C0276721

Summaries for Phaeohyphomycosis

Disease Ontology : 12 A primary systemic mycosis located in subcutaneous tissues, located in brain, located in sinuses, located in lungs, or located in peritoneal cavity, has material basis in Exophiala dermatitidis, has material basis in Phialophora, has material basis in Bipolaris hawaiiensis, has material basis in Exserohilum, has material basis in Cladophialophora bantiana, has material basis in Phaeoannellomyces, has material basis in Aureobasidium, has material basis in Cladosporium cladosporoides, has material basis in Alternaria or has material basis in Rhinocladiella mackenziei and results in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals.

MalaCards based summary : Phaeohyphomycosis, also known as infection by dematiacious fungi, is related to tinea nigra and chromoblastomycosis. An important gene associated with Phaeohyphomycosis is CARD9 (Caspase Recruitment Domain Family Member 9), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and Toll Comparative Pathway. The drugs Posaconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and skin.

NIH Rare Diseases : 53 Phaeohyphomycosis refers to fungal infections caused by dematiaceous (darkly pigmented) fungi. It can be associated with a variety of clinical syndromes including invasive sinusitis; nodules or abscesses beneath the skin; keratitis; lung masses; osteomyelitis; mycotic arthritis; endocarditis; brain abscess; and wide-spread infection. Although the condition can affect anyone, it is most commonly diagnosed in people with suppressed immune systems (like those who have undergone an organ transplant) and can even be life-threatening in these populations. Treatment depends on the signs and symptoms present in each person but may include surgery and/or various antifungal medications.

Wikipedia : 76 Phaeohyphomycosis is a heterogeneous group of mycotic infections caused by dematiaceous fungi whose... more...

Related Diseases for Phaeohyphomycosis

Diseases related to Phaeohyphomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 tinea nigra 11.4
2 chromoblastomycosis 10.2
3 breast metaplastic carcinoma 10.2 FEZF1 FEZF2
4 eyelid carcinoma 10.2 FEZF1 FEZF2
5 lymph node tuberculosis 10.2 FEZF1 FEZF2
6 acute laryngitis 10.2 FEZF1 FEZF2
7 uterine inversion 10.1 FEZF1 FEZF2
8 long qt syndrome 15 10.1 CALM1 CALM2 CALM3
9 long qt syndrome 1 10.1 CALM1 CALM2 CALM3
10 external ear disease 10.1 CALM1 CALM2 CALM3
11 emery-dreifuss muscular dystrophy 5, autosomal dominant 10.1 CALM1 CALM2 CALM3
12 lymphoma 10.1
13 sporotrichosis 10.1 CALM1 CALM2 CALM3
14 otitis externa 10.1 CALM1 CALM2 CALM3
15 spontaneous ocular nystagmus 10.1 CALM1 CALM2 CALM3
16 deafness, autosomal recessive 44 10.1 CALM1 CALM2 CALM3
17 acute dacryocystitis 10.1 CALM1 CALM2 CALM3
18 dystonia 24 10.1 CALM1 CALM2 CALM3
19 gestational choriocarcinoma 10.1 CALM1 CALM2 CALM3
20 triosephosphate isomerase deficiency 10.1 CALM1 CALM2 CALM3
21 leber congenital amaurosis 2 10.1 CALM1 CALM2 CALM3
22 clear cell acanthoma 10.1 CALM1 CALM2 CALM3
23 cardiomyopathy, dilated, 1a 10.1 CALM1 CALM2 CALM3
24 cardiomyopathy, dilated, 1p 10.1 CALM1 CALM2 CALM3
25 deafness, autosomal dominant 2a 10.1 CALM1 CALM2 CALM3
26 microcephaly 2, primary, autosomal recessive, with or without cortical malformations 10.1 CALM1 CALM2 CALM3
27 ceroid lipofuscinosis, neuronal, 11 10.1 CALM1 CALM2 CALM3
28 primary cutaneous amyloidosis 10.1 CALM1 CALM2 CALM3
29 catecholaminergic polymorphic ventricular tachycardia 10.1 CALM1 CALM2 CALM3
30 primary systemic mycosis 10.0 CALM1 CALM2 CALM3 CARD9
31 otomycosis 10.0 CALM1 CALM2 CALM3 CBS
32 tinea unguium 10.0 CALM1 CALM2 CALM3 CBS
33 coccidioidomycosis 10.0 CARD9 STAT1
34 cardiac arrest 10.0 CALM1 CALM2 CALM3
35 systemic lupus erythematosus 10.0
36 arthritis 10.0
37 leukemia 10.0
38 nocardiosis 10.0
39 acquired immunodeficiency syndrome 10.0
40 mucormycosis 10.0
41 lupus erythematosus 10.0
42 mixed sleep apnea 9.9 LYZ MMD
43 rheumatoid arthritis 9.8
44 sarcoidosis 1 9.8
45 thrombocytopenic purpura, autoimmune 9.8
46 lymphoma, hodgkin, classic 9.8
47 leukemia, acute myeloid 9.8
48 lymphoma, non-hodgkin, familial 9.8
49 basal cell carcinoma 1 9.8
50 cholangitis, primary sclerosing 9.8

Graphical network of the top 20 diseases related to Phaeohyphomycosis:



Diseases related to Phaeohyphomycosis

Symptoms & Phenotypes for Phaeohyphomycosis

Drugs & Therapeutics for Phaeohyphomycosis

Drugs for Phaeohyphomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Posaconazole Approved, Investigational, Vet_approved Phase 3 171228-49-2 147912
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3 Antiparasitic Agents Phase 3
4 Antifungal Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
7 Antiprotozoal Agents Phase 3
8 Cytochrome P-450 Enzyme Inhibitors Phase 3
9 Hormone Antagonists Phase 3
10 Hormones Phase 3
11 Steroid Synthesis Inhibitors Phase 3
12 Cytochrome P-450 CYP3A Inhibitors
13 Cytochrome P-450 CYP2C9 Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Completed NCT00034632 Phase 3 Posaconazole oral suspension
2 Historical Control Study of Refractory IFI or Patients Intolerant to Standard Antifungal Therapy in Patients With Invasive Fungal Infections (Study P02387) Completed NCT00230243

Search NIH Clinical Center for Phaeohyphomycosis

Cochrane evidence based reviews: phaeohyphomycosis

Genetic Tests for Phaeohyphomycosis

Anatomical Context for Phaeohyphomycosis

MalaCards organs/tissues related to Phaeohyphomycosis:

41
Brain, Lung, Skin, Kidney, T Cells, Myeloid, Lymph Node

The Foundational Model of Anatomy Ontology organs/tissues related to Phaeohyphomycosis:

19
Lungs, Brain, Subcutaneous Tissues, Sinuses, Peritoneal Cavity

Publications for Phaeohyphomycosis

Articles related to Phaeohyphomycosis:

(show top 50) (show all 487)
# Title Authors Year
1
From phaeohyphomycosis to disseminated chromoblastomycosis: A retrospective study of infections caused by dematiaceous fungi. ( 29656841 )
2018
2
Novel treatment using topical malachite green for nasal phaeohyphomycosis caused by a new <i>Cladophialophora</i> species in a cat. ( 29854413 )
2018
3
Subcutaneous Phaeohyphomycosis Caused by Exophiala oligosperma in an Immunocompetent Host: Case Report and Literature Review. ( 29946995 )
2018
4
Nodule of Achilles tendon in a patient with kidney transplant revealing phaeohyphomycosis. ( 29473157 )
2018
5
Cutaneous phaeohyphomycosis caused by Exophiala oligosperma. ( 29747870 )
2018
6
Successful treatment of cutaneous phaeohyphomycosis caused by Exophiala lecanii-corni with voriconazole. ( 29603783 )
2018
7
Phaeohyphomycosis due to Pleurostomophora richardsiae: an uncommon cutaneous fungal infection. ( 29575383 )
2018
8
Cutaneous phaeohyphomycosis caused by Microsphaeropsis arundinis in a Japanese patient with cardiac sarcoidosis. ( 30320462 )
2018
9
Innocuous "foot lump" in patient with diabetes mellitus: A manifestation of phaeohyphomycosis. ( 30530011 )
2018
10
Polymorphous presentation of subcutaneous phaeohyphomycosis: a rare occurrence. ( 29152722 )
2018
11
A Case of Phaeohyphomycosis on the Wrist: Identification of Exophiala spinifera in Korea. ( 29606825 )
2018
12
Subcutaneous Phaeohyphomycosis: A Clinical Mimic of Skin and Soft Tissue Neoplasms-A Descriptive Study from India. ( 30105639 )
2018
13
A case of Phaeohyphomycosis caused by Corynespora cassiicola infection. ( 30170557 )
2018
14
Facial Phaeohyphomycosis in an Immunocompetent Individual: A Rare Presentation of a Rare Fungus. ( 30211731 )
2018
15
Subcutaneous phaeohyphomycosis caused by Amesia atrobrunnea in Kuwait. ( 30446389 )
2018
16
Enigma portal case: Phaeohyphomycosis by fine needle aspiration. ( 30554449 )
2018
17
Cerebral phaeohyphomycosis due to Rhinocladiella mackenziei in Persian Gulf region: A case and review. ( 29205524 )
2017
18
Cutaneous phaeohyphomycosis. ( 28295266 )
2017
19
The first case of cutaneous phaeohyphomycosis caused by<i>Bipolaris spicifera</i>in Northern China: A case report. ( 28962097 )
2017
20
Phaeohyphomycosis breast masquerading as fibroadenoma in a young teenage girl. ( 28631431 )
2017
21
Multifocal but non-disseminated phaeohyphomycosis in a healthy man via a unique mechanism: Ejection from motor vehicle accident into a vegetable field in Afghanistan resulting in multiple contaminated skin wounds. ( 28349548 )
2017
22
Chaetomiaceae Fungi, Novel Pathogens of Equine Neurotropic Phaeohyphomycosis. ( 28578629 )
2017
23
Subcutaneous phaeohyphomycosis caused by Veronaea botryosa in a Japanese patient with adult T-cell lymphoma. ( 29215152 )
2017
24
Cutaneous phaeohyphomycosis caused by Exophiala jeanselmei in a healthy individual. ( 28191648 )
2017
25
Alternaria infectoria skin infection in a renal transplant recipient: an emerging phaeohyphomycosis of occidental countries? ( 28244068 )
2017
26
A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases. ( 29766015 )
2017
27
A rare case of multiple brain abscess and probably disseminated phaeohyphomycosis due to Cladophialophora bantiana in an immunosuppressed individual from India. ( 28478966 )
2017
28
The Clinical Presentation of Subcutaneous Phaeohyphomycosis: A Case Series from Yetebon, Ethiopia. ( 29018005 )
2017
29
Disseminated phaeohyphomycosis in a dog. ( 28275534 )
2017
30
Fungal Melanonychia: Ungual Phaeohyphomycosis caused by Botryosphaeria dothidea. ( 28293689 )
2017
31
Phaeohyphomycosis of the Face Masquerading as Basal Cell Carcinoma in an Immunocompetent Patient. ( 28761846 )
2017
32
Genome Sequence of Type Strain Fonsecaea multimorphosa CBS 980.96(T), a Causal Agent of Feline Cerebral Phaeohyphomycosis. ( 28209838 )
2017
33
Subcutaneous phaeohyphomycosis in kidney transplant recipients: A series of seven cases. ( 28994174 )
2017
34
Cerebral Phaeohyphomycosis: Fulminant Encephalitic Presentation. ( 28462506 )
2017
35
Subcutaneous phaeohyphomycosis in an immunocompetent Individual: A case report. ( 28217468 )
2017
36
Cutaneous phaeohyphomycosis in a hematopoietic stem cell transplant patient caused by Alternaria rosae: First case report. ( 28295973 )
2017
37
A case of subcutaneous phaeohyphomycosis associated with leprosy. ( 28558644 )
2017
38
Subcutaneous cystic phaeohyphomycosis due to Pleurostomophora richardsiae. ( 28186363 )
2017
39
Vasculitis causing massive infarction: a rare presentation of primary cerebral phaeohyphomycosis. ( 28764590 )
2017
40
Diversity of Veronaea botryosa from different hosts and evaluation of laboratory challenge models for phaeohyphomycosis in Acipenser transmontanus. ( 28627488 )
2017
41
Phaeohyphomycosis due to Exophiala infections in solid organ transplant recipients: Case report and literature review. ( 28500778 )
2017
42
Impaired Specific Antifungal Immunity inA CARD9-Deficient Patients withA Phaeohyphomycosis. ( 29080677 )
2017
43
Acral lentiginous melanoma with dematiaceous fungal elements of Chaetomium globosum: A saprophytism or coexistence of superficial phaeohyphomycosis? ( 28836689 )
2017
44
Cutaneous phaeohyphomycosis caused by Exophiala dermatitidis: A case report and literature review. ( 26658392 )
2016
45
Cardiothoracic surgical site phaeohyphomycosis caused by Bipolaris mould, multiple US states, 2008-2013: a clinical description. ( 26705838 )
2016
46
Phaeohyphomycosis infection in the knee. ( 27069894 )
2016
47
Subcutaneous Phaeohyphomycosis Cyst Associated with Medicopsis romeroi in an Immunocompromised Host. ( 27193294 )
2016
48
Disseminated Phaeohyphomycosis with Brain Abscess and Biliary Invasion Due to Bipolaris spp. in an Immunocompetent Patient. ( 27466308 )
2016
49
Subcutaneous Phaeohyphomycosis Caused by Pyrenochaeta romeroi in a Rheumatoid Arthritis Patient: A Case Report with Review of the Literature. ( 27287745 )
2016
50
Subcutaneous Phaeohyphomycosis due to Alternaria dennisii in an 85-year-old Immunocompromised Patient. ( 26775805 )
2016

Variations for Phaeohyphomycosis

Expression for Phaeohyphomycosis

Search GEO for disease gene expression data for Phaeohyphomycosis.

Pathways for Phaeohyphomycosis

Pathways related to Phaeohyphomycosis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.27 CALM1 CALM2 CALM3 CARD9 PSMA6
2
Show member pathways
12.26 CALM1 CALM2 CALM3 STAT1
3
Show member pathways
12.11 CALM1 CALM2 CALM3 LYZ
4
Show member pathways
11.94 CALM1 CALM2 CALM3
5
Show member pathways
11.92 CALM1 CALM2 CALM3
6
Show member pathways
11.9 CALM1 CALM2 CALM3
7
Show member pathways
11.87 CALM1 CALM2 CALM3
8 11.86 CALM1 CALM2 CALM3
9
Show member pathways
11.81 CALM1 CALM2 CALM3
10 11.81 CALM1 CALM2 CALM3 CARD9 STAT1
11
Show member pathways
11.8 CALM1 CALM2 CALM3
12 11.8 CALM1 CALM2 CALM3 STAT1
13 11.74 CALM1 CALM2 CALM3 STAT1
14
Show member pathways
11.73 CALM1 CALM2 CALM3
15
Show member pathways
11.72 CALM1 CALM2 CALM3
16
Show member pathways
11.7 CALM1 CALM2 CALM3
17 11.7 CALM1 CALM2 CALM3
18
Show member pathways
11.69 CALM1 CALM2 CALM3
19
Show member pathways
11.69 CALM1 CALM2 CALM3 STAT1
20 11.68 CALM1 CALM2 CALM3
21
Show member pathways
11.63 CALM1 CALM2 CALM3
22 11.61 CALM1 CALM2 STAT1
23 11.61 CALM1 CALM2 CALM3
24
Show member pathways
11.59 CALM1 CALM2 CALM3 CARD9 STAT1
25 11.58 CALM1 CALM2 CALM3
26
Show member pathways
11.57 CALM1 CALM2 CALM3
27 11.48 CALM1 CALM2 CALM3
28 11.48 CALM1 CALM2 CALM3
29 11.32 CALM1 CALM2 CALM3
30 11.31 CALM1 CALM2 CALM3
31 11.29 CALM1 CALM2 CALM3
32 11.25 CALM1 CALM2 CALM3
33 11.22 CALM1 CALM2 CALM3
34 11.2 CALM1 CALM2 CALM3 STAT1
35 11.15 CALM1 CALM2 CALM3
36 11.13 CALM1 CALM2 CALM3
37 11.12 CALM1 CALM2 CALM3
38 10.89 CALM1 CALM2 CALM3
39 10.78 CALM1 CALM2 CALM3
40 10.71 CALM1 CALM2 CALM3
41 9.91 CALM1 CALM2 CALM3

GO Terms for Phaeohyphomycosis

Cellular components related to Phaeohyphomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
2 spindle microtubule GO:0005876 9.43 CALM1 CALM2 CALM3
3 calcium channel complex GO:0034704 9.33 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.26 CALM1 CALM2 CALM3 PSMA6
5 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Phaeohyphomycosis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron differentiation GO:0045666 9.81 FEZF1 FEZF2 MMD
2 calcium-mediated signaling GO:0019722 9.8 CALM1 CALM2 CALM3
3 response to calcium ion GO:0051592 9.79 CALM1 CALM2 CALM3
4 positive regulation of protein serine/threonine kinase activity GO:0071902 9.77 CALM1 CALM2 CALM3
5 substantia nigra development GO:0021762 9.76 CALM1 CALM2 CALM3
6 regulation of cytokinesis GO:0032465 9.74 CALM1 CALM2 CALM3
7 regulation of heart rate GO:0002027 9.73 CALM1 CALM2 CALM3
8 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.72 CALM1 CALM2 CALM3
9 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
10 positive regulation of protein autophosphorylation GO:0031954 9.69 CALM1 CALM2 CALM3
11 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 CALM1 CALM2 CALM3
12 positive regulation of nitric-oxide synthase activity GO:0051000 9.65 CALM1 CALM3
13 cytolysis GO:0019835 9.65 LYZ MMD
14 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.65 CALM1 CALM2 CALM3
15 response to corticosterone GO:0051412 9.64 CALM1 CALM3
16 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.64 CALM1 CALM3
17 regulation of cardiac muscle contraction GO:0055117 9.63 CALM1 CALM2 CALM3
18 regulation of synaptic vesicle endocytosis GO:1900242 9.62 CALM1 CALM3
19 establishment of protein localization to membrane GO:0090150 9.62 CALM1 CALM3
20 regulation of high voltage-gated calcium channel activity GO:1901841 9.61 CALM1 CALM3
21 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
22 cell dedifferentiation GO:0043697 9.6 FEZF1 FEZF2
23 forebrain anterior/posterior pattern specification GO:0021797 9.58 FEZF1 FEZF2
24 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
25 establishment of protein localization to mitochondrial membrane GO:0090151 9.54 CALM1 CALM3
26 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
27 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
28 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
29 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
30 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
31 positive regulation by host of symbiont cAMP-mediated signal transduction GO:0075206 8.8 CALM1 CALM2 CALM3

Molecular functions related to Phaeohyphomycosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.8 CALM1 CALM2 CALM3 CARD9
2 ion channel binding GO:0044325 9.71 CALM1 CALM2 CALM3
3 protein N-terminus binding GO:0047485 9.7 CALM1 CALM3 SLA2
4 disordered domain specific binding GO:0097718 9.61 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.58 CALM1 CALM2 CALM3
6 phosphatidylinositol 3-kinase binding GO:0043548 9.55 CALM1 CALM3
7 nitric-oxide synthase binding GO:0050998 9.51 CALM1 CALM3
8 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
9 calcium channel inhibitor activity GO:0019855 9.48 CALM1 CALM2
10 nitric-oxide synthase regulator activity GO:0030235 9.46 CALM1 CALM3
11 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
12 type 3 metabotropic glutamate receptor binding GO:0031800 9.37 CALM1 CALM3
13 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
14 adenylate cyclase activator activity GO:0010856 9.13 CALM1 CALM2 CALM3
15 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Phaeohyphomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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