MCID: PHH001
MIFTS: 39

Phaeohyphomycosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Phaeohyphomycosis

MalaCards integrated aliases for Phaeohyphomycosis:

Name: Phaeohyphomycosis 12 53 15 73
Infection by Dematiacious Fungi 12
Phaehyphomycosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14049
UMLS 73 C0276721

Summaries for Phaeohyphomycosis

Disease Ontology : 12 A primary systemic mycosis located in subcutaneous tissues, located in brain, located in sinuses, located in lungs, or located in peritoneal cavity, has material basis in Exophiala dermatitidis, has material basis in Phialophora, has material basis in Bipolaris hawaiiensis, has material basis in Exserohilum, has material basis in Cladophialophora bantiana, has material basis in Phaeoannellomyces, has material basis in Aureobasidium, has material basis in Cladosporium cladosporoides, has material basis in Alternaria or has material basis in Rhinocladiella mackenziei and results in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals.

MalaCards based summary : Phaeohyphomycosis, also known as infection by dematiacious fungi, is related to tinea nigra and cerebritis. An important gene associated with Phaeohyphomycosis is CARD9 (Caspase Recruitment Domain Family Member 9). The drugs Miconazole and Posaconazole have been mentioned in the context of this disorder. Affiliated tissues include subcutaneous tissues, brain and sinuses, and related phenotype is taste/olfaction.

NIH Rare Diseases : 53 Phaeohyphomycosis refers to fungal infections caused by dematiaceous (darkly pigmented) fungi. It can be associated with a variety of clinical syndromes including invasive sinusitis; nodules or abscesses beneath the skin; keratitis; lung masses; osteomyelitis; mycotic arthritis; endocarditis; brain abscess; and wide-spread infection. Although the condition can affect anyone, it is most commonly diagnosed in people with suppressed immune systems (like those who have undergone an organ transplant) and can even be life-threatening in these populations. Treatment depends on the signs and symptoms present in each person but may include surgery and/or various antifungal medications.

Wikipedia : 76 Phaeohyphomycosis is a heterogeneous group of mycotic infections caused by dematiaceous fungi whose... more...

Related Diseases for Phaeohyphomycosis

Graphical network of the top 20 diseases related to Phaeohyphomycosis:



Diseases related to Phaeohyphomycosis

Symptoms & Phenotypes for Phaeohyphomycosis

MGI Mouse Phenotypes related to Phaeohyphomycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 FEZF1 FEZF2

Drugs & Therapeutics for Phaeohyphomycosis

Drugs for Phaeohyphomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
2
Posaconazole Approved, Investigational, Vet_approved Phase 3 171228-49-2 147912
3 Antifungal Agents Phase 3
4 Anti-Infective Agents Phase 3
5 Antiparasitic Agents Phase 3
6 Antiprotozoal Agents Phase 3
7 Cytochrome P-450 Enzyme Inhibitors Phase 3
8 Hormone Antagonists Phase 3
9 Hormones Phase 3
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
11 Steroid Synthesis Inhibitors Phase 3
12 Cytochrome P-450 CYP2C9 Inhibitors
13 Cytochrome P-450 CYP3A Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Completed NCT00034632 Phase 3 Posaconazole oral suspension
2 Historical Control Study of Refractory IFI or Patients Intolerant to Standard Antifungal Therapy in Patients With Invasive Fungal Infections (Study P02387) Completed NCT00230243

Search NIH Clinical Center for Phaeohyphomycosis

Genetic Tests for Phaeohyphomycosis

Anatomical Context for Phaeohyphomycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Phaeohyphomycosis:

19
Subcutaneous Tissues, Brain, Sinuses, Lungs, Peritoneal Cavity

MalaCards organs/tissues related to Phaeohyphomycosis:

41
Brain, Lung, Skin, Kidney, Liver, T Cells, Heart

Publications for Phaeohyphomycosis

Articles related to Phaeohyphomycosis:

(show top 50) (show all 466)
# Title Authors Year
1
From phaeohyphomycosis to disseminated chromoblastomycosis: A retrospective study of infections caused by dematiaceous fungi. ( 29656841 )
2018
2
Novel treatment using topical malachite green for nasal phaeohyphomycosis caused by a new <i>Cladophialophora</i> species in a cat. ( 29854413 )
2018
3
Subcutaneous Phaeohyphomycosis Caused by Exophiala oligosperma in an Immunocompetent Host: Case Report and Literature Review. ( 29946995 )
2018
4
Nodule of Achilles tendon in a patient with kidney transplant revealing phaeohyphomycosis. ( 29473157 )
2018
5
Cutaneous phaeohyphomycosis caused by Exophiala oligosperma. ( 29747870 )
2018
6
Successful treatment of cutaneous phaeohyphomycosis caused by Exophiala lecanii-corni with voriconazole. ( 29603783 )
2018
7
Phaeohyphomycosis due to Pleurostomophora richardsiae: an uncommon cutaneous fungal infection. ( 29575383 )
2018
8
Polymorphous presentation of subcutaneous phaeohyphomycosis: a rare occurrence. ( 29152722 )
2018
9
A Case of Phaeohyphomycosis on the Wrist: Identification of <i>Exophiala spinifera</i> in Korea. ( 29606825 )
2018
10
Cerebral phaeohyphomycosis due to Rhinocladiella mackenziei in Persian Gulf region: A case and review. ( 29205524 )
2017
11
Cutaneous phaeohyphomycosis. ( 28295266 )
2017
12
The first case of cutaneous phaeohyphomycosis caused by<i>Bipolaris spicifera</i>in Northern China: A case report. ( 28962097 )
2017
13
Phaeohyphomycosis breast masquerading as fibroadenoma in a young teenage girl. ( 28631431 )
2017
14
Multifocal but non-disseminated phaeohyphomycosis in a healthy man via a unique mechanism: Ejection from motor vehicle accident into a vegetable field in Afghanistan resulting in multiple contaminated skin wounds. ( 28349548 )
2017
15
Chaetomiaceae Fungi, Novel Pathogens of Equine Neurotropic Phaeohyphomycosis. ( 28578629 )
2017
16
Subcutaneous phaeohyphomycosis caused by Veronaea botryosa in a Japanese patient with adult T-cell lymphoma. ( 29215152 )
2017
17
Cutaneous phaeohyphomycosis caused by Exophiala jeanselmei in a healthy individual. ( 28191648 )
2017
18
Alternaria infectoria skin infection in a renal transplant recipient: an emerging phaeohyphomycosis of occidental countries? ( 28244068 )
2017
19
A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases. ( 29766015 )
2017
20
A rare case of multiple brain abscess and probably disseminated phaeohyphomycosis due to Cladophialophora bantiana in an immunosuppressed individual from India. ( 28478966 )
2017
21
The Clinical Presentation of Subcutaneous Phaeohyphomycosis: A Case Series from Yetebon, Ethiopia. ( 29018005 )
2017
22
Disseminated phaeohyphomycosis in a dog. ( 28275534 )
2017
23
Fungal Melanonychia: Ungual Phaeohyphomycosis caused by Botryosphaeria dothidea. ( 28293689 )
2017
24
Phaeohyphomycosis of the Face Masquerading as Basal Cell Carcinoma in an Immunocompetent Patient. ( 28761846 )
2017
25
Genome Sequence of Type Strain Fonsecaea multimorphosa CBS 980.96(T), a Causal Agent of Feline Cerebral Phaeohyphomycosis. ( 28209838 )
2017
26
Subcutaneous phaeohyphomycosis in kidney transplant recipients: A series of seven cases. ( 28994174 )
2017
27
Cerebral Phaeohyphomycosis: Fulminant Encephalitic Presentation. ( 28462506 )
2017
28
Subcutaneous phaeohyphomycosis in an immunocompetent Individual: A case report. ( 28217468 )
2017
29
Cutaneous phaeohyphomycosis in a hematopoietic stem cell transplant patient caused by Alternaria rosae: First case report. ( 28295973 )
2017
30
A case of subcutaneous phaeohyphomycosis associated with leprosy. ( 28558644 )
2017
31
Subcutaneous cystic phaeohyphomycosis due to Pleurostomophora richardsiae. ( 28186363 )
2017
32
Vasculitis causing massive infarction: a rare presentation of primary cerebral phaeohyphomycosis. ( 28764590 )
2017
33
Diversity of Veronaea botryosa from different hosts and evaluation of laboratory challenge models for phaeohyphomycosis in Acipenser transmontanus. ( 28627488 )
2017
34
Phaeohyphomycosis due to Exophiala infections in solid organ transplant recipients: Case report and literature review. ( 28500778 )
2017
35
Impaired Specific Antifungal Immunity inA CARD9-Deficient Patients withA Phaeohyphomycosis. ( 29080677 )
2017
36
Acral lentiginous melanoma with dematiaceous fungal elements of Chaetomium globosum: A saprophytism or coexistence of superficial phaeohyphomycosis? ( 28836689 )
2017
37
Cutaneous phaeohyphomycosis caused by Exophiala dermatitidis: A case report and literature review. ( 26658392 )
2016
38
Cardiothoracic surgical site phaeohyphomycosis caused by Bipolaris mould, multiple US states, 2008-2013: a clinical description. ( 26705838 )
2016
39
Phaeohyphomycosis infection in the knee. ( 27069894 )
2016
40
Subcutaneous Phaeohyphomycosis Cyst Associated with Medicopsis romeroi in an Immunocompromised Host. ( 27193294 )
2016
41
Disseminated Phaeohyphomycosis with Brain Abscess and Biliary Invasion Due to Bipolaris spp. in an Immunocompetent Patient. ( 27466308 )
2016
42
Subcutaneous Phaeohyphomycosis Caused by Pyrenochaeta romeroi in a Rheumatoid Arthritis Patient: A Case Report with Review of the Literature. ( 27287745 )
2016
43
Subcutaneous Phaeohyphomycosis due to Alternaria dennisii in an 85-year-old Immunocompromised Patient. ( 26775805 )
2016
44
A rare case of phaeohyphomycosis caused by Fonsecaea pedrosoi in a child with nephrotic syndrome. ( 27194840 )
2016
45
Clinical spectrum of phaeohyphomycosis in solid organ transplant recipients. ( 27981220 )
2016
46
Phaeohyphomycosis due to Pyrenophora phaeocomes and Drechslera nobleae in an Appaloosa mare. ( 27041763 )
2016
47
Unusual ocular presentations of ocular phaeohyphomycosis. ( 27447296 )
2016
48
&amp;quot;A fine needle aspiration cytology in time saves nine&amp;quot; - cutaneous phaeohyphomycosis caused by Exophiala jeanselmei in a renal transplant patient: Diagnosis by fine needle aspiration cytology. ( 27011447 )
2016
49
Genomic Analyses of Cladophialophora bantiana, a Major Cause of Cerebral Phaeohyphomycosis Provides Insight into Its Lifestyle, Virulence and Adaption in Host. ( 27570972 )
2016
50
Subcutaneous Phaeohyphomycosis caused by Cladophialophora bantiana after Abdominal Hernia Surgery. ( 27735161 )
2016

Variations for Phaeohyphomycosis

Expression for Phaeohyphomycosis

Search GEO for disease gene expression data for Phaeohyphomycosis.

Pathways for Phaeohyphomycosis

GO Terms for Phaeohyphomycosis

Biological processes related to Phaeohyphomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.4 FEZF1 FEZF2
2 positive regulation of neuron differentiation GO:0045666 9.37 FEZF1 FEZF2
3 forebrain development GO:0030900 9.32 FEZF1 FEZF2
4 regulation of neurogenesis GO:0050767 9.26 FEZF1 FEZF2
5 telencephalon development GO:0021537 9.16 FEZF1 FEZF2
6 forebrain anterior/posterior pattern specification GO:0021797 8.96 FEZF1 FEZF2
7 cell dedifferentiation GO:0043697 8.62 FEZF1 FEZF2

Molecular functions related to Phaeohyphomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 CBS PAM

Sources for Phaeohyphomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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