MCID: PHG002
MIFTS: 34

Phagocyte Bactericidal Dysfunction

Categories: Immune diseases, Infectious diseases

Aliases & Classifications for Phagocyte Bactericidal Dysfunction

MalaCards integrated aliases for Phagocyte Bactericidal Dysfunction:

Name: Phagocyte Bactericidal Dysfunction 12 44 15 17 71
Phagocytic Dysfunction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3262
MeSH 44 D010585
UMLS 71 C0031306

Summaries for Phagocyte Bactericidal Dysfunction

Disease Ontology : 12 A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection.

MalaCards based summary : Phagocyte Bactericidal Dysfunction, also known as phagocytic dysfunction, is related to chronic granulomatous disease and immunodeficiency 34. An important gene associated with Phagocyte Bactericidal Dysfunction is CYBB (Cytochrome B-245 Beta Chain), and among its related pathways/superpathways are Integrin Pathway and PAK Pathway. The drug Omega 3 Fatty Acid has been mentioned in the context of this disorder. Affiliated tissues include neutrophil and monocytes, and related phenotypes are hematopoietic system and cellular

Wikipedia : 74 Phagocyte bactericidal dysfunction refers to a class of medical conditions where phagocytes have a... more...

Related Diseases for Phagocyte Bactericidal Dysfunction

Diseases related to Phagocyte Bactericidal Dysfunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 chronic granulomatous disease 29.3 XK RAC2 PPP1R12C PMM2 NOXO1 NOXA1
2 immunodeficiency 34 11.3
3 suppurative lymphadenitis 10.3 NCF2 NCF1 CYBB
4 lung abscess 10.3 NCF2 NCF1 CYBA
5 bacillary angiomatosis 10.2 MT-CYB CD34
6 ileocolitis 10.2 NOX1 DUOX2
7 rhinosporidiosis 10.2 DUOX2 DUOX1
8 granulomatous disease, chronic, autosomal recessive, 2 10.2 PMM2 NCF2 ALG3
9 bartonellosis 10.2 MT-CYB CD34
10 granulomatous disease, chronic, autosomal recessive, 3 10.2 PMM2 NCF4 ALG3
11 acute dacryocystitis 10.2 DUOX2 DUOX1
12 lung mucoepidermoid carcinoma 10.2 NOXO1 NOXA1
13 ectodermal dysplasia 10.2 NCF2 NCF1 CYBB CYBA
14 cardiomyopathy, familial hypertrophic, 2 10.1 NOXA1 DUOX2 DUOX1 CYBB
15 parasitic ichthyosporea infectious disease 10.1 DUOX2 DUOX1
16 x-linked recessive disease 10.1 LMO2 CYBB CD34
17 adenosine deaminase deficiency 10.1 LMO2 CD34 ADA
18 severe combined immunodeficiency, x-linked 10.0 LMO2 CD34 ADA
19 retinitis pigmentosa 47 10.0 RAC2 NOX1 NCF2 NCF1 MT-CYB
20 granulomatous disease, chronic, autosomal recessive, 1 10.0 PMM2 NCF2 NCF1 CYBB CYBA ALG3
21 haemophilus influenzae 10.0
22 congenital disorder of glycosylation, type iia 9.9 PMM2 ALG3
23 severe combined immunodeficiency 9.9 RAC2 LMO2 CD34 ADA
24 granulomatous disease, chronic, autosomal recessive, 4 9.8 NOX1 NCF4 NCF2 NCF1 DUOX2 DUOX1
25 epidermodysplasia verruciformis 1 9.8
26 pulmonary disease, chronic obstructive 9.8
27 obstructive jaundice 9.8
28 bronchitis 9.8
29 periodontitis 9.8
30 lung disease 9.8
31 bronchiectasis 9.8
32 hypertension, essential 9.7 NOX1 NCF2 NCF1 DUOX2 DUOX1 CYBB
33 granulomatous disease, chronic, x-linked 8.8 XK PPP1R12C NOXA1 NOX1 NCF4 NCF2

Graphical network of the top 20 diseases related to Phagocyte Bactericidal Dysfunction:



Diseases related to Phagocyte Bactericidal Dysfunction

Symptoms & Phenotypes for Phagocyte Bactericidal Dysfunction

MGI Mouse Phenotypes related to Phagocyte Bactericidal Dysfunction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.18 ADA CD34 CYBA CYBB DUOX2 LMO2
2 cellular MP:0005384 10.14 ADA CD34 CYBA CYBB LMO2 MECOM
3 cardiovascular system MP:0005385 10.13 ADA CYBA CYBB DUOX2 LMO2 MECOM
4 homeostasis/metabolism MP:0005376 10.13 ADA CD34 CYBA CYBB DUOX2 MECOM
5 immune system MP:0005387 10.07 ADA CD34 CYBA CYBB DUOX2 LMO2
6 liver/biliary system MP:0005370 9.7 ADA DUOX2 LMO2 MECOM NCF1 PMM2
7 muscle MP:0005369 9.5 ADA CYBB MECOM NCF1 NOX1 PMM2
8 renal/urinary system MP:0005367 9.17 ADA CYBB DUOX2 LMO2 NCF1 NCF2

Drugs & Therapeutics for Phagocyte Bactericidal Dysfunction

Drugs for Phagocyte Bactericidal Dysfunction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Omega 3 Fatty Acid

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Trial of Standard or DHA/EPA Supplemented Enteral Nutrition in Patients Undergoing Laparoscopic Colorectal Surgery Unknown status NCT03598413

Search NIH Clinical Center for Phagocyte Bactericidal Dysfunction

Cochrane evidence based reviews: phagocyte bactericidal dysfunction

Genetic Tests for Phagocyte Bactericidal Dysfunction

Anatomical Context for Phagocyte Bactericidal Dysfunction

MalaCards organs/tissues related to Phagocyte Bactericidal Dysfunction:

40
Neutrophil, Monocytes

Publications for Phagocyte Bactericidal Dysfunction

Articles related to Phagocyte Bactericidal Dysfunction:

(show top 50) (show all 58)
# Title Authors PMID Year
1
Alcohol induces mitochondrial derangements in alveolar macrophages by upregulating NADPH oxidase 4. 61
33278514 2021
2
[Analysis of the Development Mechanism of Cytokine Storm in Severe Burn Patients Complicated with Infection]. 61
33474883 2021
3
Neutrophil dysfunction in bronchiectasis: an emerging role for immunometabolism. 61
33509959 2021
4
E-cigarettes and health risks: more to the flavour than just the name. 61
33295836 2020
5
Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children. 61
32176839 2020
6
Alcohol-induced mitochondrial DNA damage promotes injurious crosstalk between alveolar epithelial cells and alveolar macrophages. 61
31307864 2019
7
Glial phagocytic clearance in Parkinson's disease. 61
30953527 2019
8
GM-CSF Administration Improves Defects in Innate Immunity and Sepsis Survival in Obese Diabetic Mice. 61
30578307 2019
9
Quantified F-Actin Morphology Is Predictive of Phagocytic Capacity of Stem Cell-Derived Retinal Pigment Epithelium. 61
29456184 2018
10
RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells. 61
29534722 2018
11
Dysregulation of Alveolar Macrophage PPARγ, NADPH Oxidases, and TGFβ1 in Otherwise Healthy HIV-Infected Individuals. 61
28314381 2017
12
Phagocytosis and Inflammation: Exploring the effects of the components of E-cigarette vapor on macrophages. 61
28867672 2017
13
Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells. 61
28539592 2017
14
Chronic Granulomatous Disease Presenting as Aspergillus Fumigatus Pneumonia in a Previously Healthy Young Woman. 61
28377567 2017
15
Oxidative stress induced by Se-deficient high-energy diet implicates neutrophil dysfunction via Nrf2 pathway suppression in swine. 61
28077800 2017
16
Peroxisome Proliferator-Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction. 61
26677910 2016
17
Human umbilical tissue-derived cells rescue retinal pigment epithelium dysfunction in retinal degeneration. 61
26523756 2016
18
Is Alveolar Macrophage Phagocytic Dysfunction in Children With Protracted Bacterial Bronchitis a Forerunner to Bronchiectasis? 61
26867834 2016
19
Behçet's disease heterogeneity: cytokine production and oxidative burst of phagocytes are altered in patients with severe manifestations. 61
26394190 2015
20
Assessment of phagocytic activity of neutrophils in chronic obstructive pulmonary disease. 61
26628755 2015
21
Phagocytic function of Kupffer cells in mouse nonalcoholic fatty liver disease models: Evaluation with superparamagnetic iron oxide. 61
24916329 2015
22
TUDCA Promotes Phagocytosis by Retinal Pigment Epithelium via MerTK Activation. 61
25804419 2015
23
Impaired clearance of early apoptotic cells mediated by inhibitory IgG antibodies in patients with primary Sjögren's syndrome. 61
25396412 2014
24
Phagocytic dysfunction of human alveolar macrophages and severity of chronic obstructive pulmonary disease. 61
23908477 2013
25
Lessons learned from phagocytic function studies in a large cohort of patients with recurrent infections. 61
22207252 2012
26
CD14 expression and Kupffer cell dysfunction in non-alcoholic steatohepatitis: superparamagnetic iron oxide-magnetic resonance image and pathologic correlation. 61
22188204 2012
27
Evidence of neutrophil functional defect despite inflammation in stable cirrhosis. 61
21236309 2011
28
A case of acute retinal pigment epithelitis: spectral domain optical coherence tomography time course and physiopathologic hypothesis. 61
20922038 2010
29
Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis. 61
18931325 2009
30
Role of Toll-like receptors 2, 4, and 9 in mediating neutrophil dysfunction in alcoholic hepatitis. 61
19033535 2009
31
Ammonia impairs neutrophil phagocytic function in liver disease. 61
18697192 2008
32
Cerebral aspergillosis in an infant with corticosteroid-resistant nephrotic syndrome. 61
12736806 2003
33
[Beta-carotene prevention of immune disorders in workers engaged in the fire copper refining]. 61
12077977 2002
34
[Immunology in the medical practice. XXXI. Hereditary immune deficiencies: relationship between clinical symptoms and abnormalities of the immune system]. 61
10941433 2000
35
Macrophage phagocytic dysfunction and reduced metabolic response in experimental obstructive jaundice. 61
7811830 1994
36
Elevated polymorphonuclear phagocytic function in thalassemia patients by chemiluminescence. 61
8002069 1994
37
Phagocytic function of monocyte-derived macrophages is not affected by human immunodeficiency virus type 1 infection. 61
8390549 1993
38
Assay of phagocytic cell functions. 61
8385468 1993
39
Liver bacterial clearance following hepatic artery ligation and portacaval shunt. 61
1881140 1991
40
Periodontitis in the primary dentition associated with Actinobacillus actinomycetemcomitans infection and leukocyte dysfunction. A 3 1/2 year follow-up. 61
2347951 1990
41
Comparison of immunosuppressive effects of cyclosporine A in a murine model of systemic candidiasis and of localized thrushlike lesions. 61
2807532 1989
42
[Neutrophil phagocytic dysfunction in patients with periodontitis]. 61
3478178 1987
43
Gammaglobulin for intravenous use induces an Fc gamma receptor-specific decrement in phagocytosis by blood monocytes. 61
2435438 1987
44
Plasma fibronectin. 61
3790862 1986
45
Ingestion of hydroxyethyl starch by human leukocytes. 61
2418551 1986
46
Normalization of monocyte candidacidal deficiency by cyclooxygenase inhibitors in Hodgkin's disease. 61
3922613 1985
47
Influenza virus-induced immune complexes suppress alveolar macrophage phagocytosis. 61
6708169 1984
48
Impaired bacterial clearance and trapping in obstructive jaundice. 61
6362581 1984
49
Actin-induced reticuloendothelial phagocytic depression as mediated by its interaction with fibronectin. 61
6832344 1983
50
Opsonic fibronectin deficiency in the etiology of starvation-induced reticuloendothelial phagocytic dysfunction. 61
7060722 1982

Variations for Phagocyte Bactericidal Dysfunction

Expression for Phagocyte Bactericidal Dysfunction

Search GEO for disease gene expression data for Phagocyte Bactericidal Dysfunction.

Pathways for Phagocyte Bactericidal Dysfunction

Pathways related to Phagocyte Bactericidal Dysfunction according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 RAC2 NOX1 NCF4 NCF2 NCF1 CYBB
2
Show member pathways
13.13 RAC2 NOX1 NCF4 NCF2 NCF1 CYBB
3
Show member pathways
12.77 RAC2 NOXO1 NOXA1 NOX1 NCF4 NCF2
4
Show member pathways
12.72 RAC2 NCF4 NCF2 NCF1 MT-CYB CYBB
5
Show member pathways
12.57 RAC2 NCF4 NCF2 NCF1 CYBB CYBA
6
Show member pathways
12.4 NCF4 NCF2 NCF1 CYBB CYBA
7 12.39 NCF4 NCF1 MECOM CD34
8
Show member pathways
12.39 NCF4 NCF2 NCF1 CYBB CYBA
9
Show member pathways
12.26 RAC2 NCF2 NCF1 CYBB CYBA
10
Show member pathways
12.22 RAC2 NOXO1 NOXA1 NOX1 NCF2 NCF1
11
Show member pathways
12.17 NCF4 NCF2 NCF1 CYBB CYBA
12 12.06 NCF4 NCF2 NCF1 CYBB CYBA
13 11.97 RAC2 NOX1 NCF2 NCF1 CYBA
14 11.95 RAC2 NOXA1 NCF2 NCF1 CYBB CYBA
15 11.91 NOX1 NCF4 NCF2 NCF1 CYBA
16
Show member pathways
11.4 RAC2 NCF4 NCF2 NCF1 CYBB CYBA
17
Show member pathways
11.29 NCF4 NCF2 NCF1 CYBB CYBA
18 11.09 RAC2 NCF4 CYBA
19 10.39 RAC2 NOXO1 NOXA1 NOX1 NCF4 NCF2

GO Terms for Phagocyte Bactericidal Dysfunction

Cellular components related to Phagocyte Bactericidal Dysfunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.18 XK RAC2 NOXO1 NOXA1 NOX1 NCF1
2 membrane GO:0016020 10.16 XK RAC2 NOXO1 NOXA1 NOX1 NCF4
3 apical plasma membrane GO:0016324 9.73 DUOX2 DUOX1 CYBA CD34
4 neuronal cell body GO:0043025 9.55 PMM2 NCF1 CYBB CYBA ADA
5 phagocytic vesicle membrane GO:0030670 9.5 RAC2 CYBB CYBA
6 perinuclear endoplasmic reticulum GO:0097038 9.37 CYBB CYBA
7 NADPH oxidase complex GO:0043020 9.32 NOXO1 NOXA1 NOX1 NCF4 NCF2 NCF1
8 phagolysosome GO:0032010 9.13 NCF4 NCF2 NCF1

Biological processes related to Phagocyte Bactericidal Dysfunction according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 10.02 NOX1 NCF4 NCF2 NCF1 MT-CYB DUOX2
2 regulation of catalytic activity GO:0050790 9.96 PPP1R12C NOXO1 NOXA1 NCF4 NCF2
3 response to drug GO:0042493 9.9 MT-CYB CYBB CYBA ADA
4 defense response GO:0006952 9.87 NOX1 DUOX2 DUOX1 CYBB
5 cellular response to oxidative stress GO:0034599 9.85 NCF4 NCF2 NCF1 CYBB CYBA
6 electron transport chain GO:0022900 9.81 NCF2 NCF1 CYBB CYBA
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.8 NCF4 NCF2 NCF1 CYBB CYBA
8 cell redox homeostasis GO:0045454 9.73 RAC2 NCF4 NCF2 NCF1 CYBB CYBA
9 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.72 NCF4 NCF2 NCF1 CYBB CYBA
10 hydrogen peroxide biosynthetic process GO:0050665 9.67 DUOX2 DUOX1 CYBA
11 regulation of hydrogen peroxide metabolic process GO:0010310 9.65 RAC2 NOXO1 NOXA1
12 respiratory burst GO:0045730 9.63 NOX1 NCF4 NCF2 NCF1 CYBB CYBA
13 positive regulation of cell motility GO:2000147 9.61 DUOX2 DUOX1
14 regulation of respiratory burst GO:0060263 9.61 RAC2 NOXO1 NOXA1
15 thyroid hormone generation GO:0006590 9.59 DUOX2 DUOX1
16 hematopoietic stem cell proliferation GO:0071425 9.58 MECOM CD34
17 hormone biosynthetic process GO:0042446 9.58 DUOX2 DUOX1
18 cellular response to L-glutamine GO:1904845 9.55 CYBB CYBA
19 response to aldosterone GO:1904044 9.54 CYBB CYBA
20 cuticle development GO:0042335 9.52 DUOX2 DUOX1
21 superoxide metabolic process GO:0006801 9.5 NOXO1 NOXA1 NCF4 NCF2 NCF1 CYBB
22 superoxide anion generation GO:0042554 9.23 NOXA1 NOX1 NCF2 NCF1 DUOX2 DUOX1

Molecular functions related to Phagocyte Bactericidal Dysfunction according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.43 XK RAC2 PPP1R12C PMM2 NOXO1 NOXA1
2 oxidoreductase activity GO:0016491 9.8 NOX1 MT-CYB DUOX2 DUOX1 CYBB CYBA
3 SH3 domain binding GO:0017124 9.67 NOXA1 NCF1 CYBA
4 phosphatidylinositol binding GO:0035091 9.65 NOXO1 NCF4 NCF1
5 molecular adaptor activity GO:0060090 9.61 NOXO1 NCF4 NCF1
6 heme binding GO:0020037 9.56 DUOX2 DUOX1 CYBB CYBA
7 electron transfer activity GO:0009055 9.55 NCF2 NCF1 MT-CYB CYBB CYBA
8 phosphatidylinositol-3-phosphate binding GO:0032266 9.54 NOXO1 NCF4 NCF1
9 NAD(P)H oxidase activity GO:0016174 9.4 DUOX2 DUOX1
10 superoxide-generating NADPH oxidase activator activity GO:0016176 9.35 NOXO1 NOXA1 NCF4 NCF2 NCF1
11 superoxide-generating NADPH oxidase activity GO:0016175 9.23 NOX1 NCF4 NCF2 NCF1 DUOX2 DUOX1

Sources for Phagocyte Bactericidal Dysfunction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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