MCID: PHR003
MIFTS: 57

Pharyngitis

Categories: Infectious diseases, Oral diseases, Respiratory diseases, Smell/Taste diseases
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Aliases & Classifications for Pharyngitis

MalaCards integrated aliases for Pharyngitis:

Name: Pharyngitis 11 75 53 43 14 71
Acute Pharyngitis 11 16 71 31 33
Chronic Pharyngitis 11 71 31 33
Persistent Sore Throat 11 33
Chronic Sore Throat 11 33
Pharyngeal Diseases 43 71
Acute Sore Throat 11 33
Chronic Pharyngitis and Nasopharyngitis 11
Acute Infective Pharyngitis Nos 33
Chronic Pharyn/nasopharyngitis 11
Acute Pharyngeal Inflammation 33
Acute Infective Pharyngitis 33
Inflammation of the Throat 33
Acute Throat Inflammation 33
Pharyngeal Inflammation 33
Sore Throat - Chronic 11
Acute Pharyngitis Nos 33
Acute Sore Throat Nos 33
Infective Pharyngitis 33
Infection of Pharynx 33
Pharyngeal Disorder 11
Pharyngitis - Acute 11
Throat Inflammation 33
Chronic Throat Pain 33
Pharyngeal Disease 11
Putrid Pharyngitis 33
Throat Infection 33
Inflamed Throat 11
Pharyngitis Nos 33
Throat Catarrh 33

Classifications:



External Ids:

Disease Ontology 11 DOID:2275
ICD9CM 34 462 472 478.20
UMLS 71 C0001344 C0031345 C0031350 more

Summaries for Pharyngitis

Disease Ontology: 11 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as sore throat. The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.

MalaCards based summary: Pharyngitis, also known as acute pharyngitis, is related to rheumatic fever and tonsillitis, and has symptoms including recurrent pharyngitis, sore throat and acute sore throat nos. An important gene associated with Pharyngitis is MIR452 (MicroRNA 452), and among its related pathways/superpathways are Innate Immune System and Toll-Like receptor Signaling Pathways. The drugs Phenoxymethylpenicillin and Tyrothricin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and tonsil, and related phenotype is immune system.

Wikipedia: 75 Pharyngitis is inflammation of the back of the throat, known as the pharynx. It typically results in a... more...

Related Diseases for Pharyngitis

Diseases related to Pharyngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 573)
# Related Disease Score Top Affiliating Genes
1 rheumatic fever 32.1 TLR2 MYOM2 HLA-DRB1
2 tonsillitis 32.0 TLR2 TLR1 LACTB IL1B CXCL8
3 necrotizing ulcerative gingivitis 32.0 IL1B CXCL8
4 cyclic neutropenia 31.9 IL1B CXCL8 CSF2
5 lymphadenitis 31.7 IL1B CXCL8 CRP
6 aphthous stomatitis 31.7 MEFV IL1B CXCL8 CRP
7 stomatitis 31.7 MEFV IL1B CXCL8 CSF2
8 familial mediterranean fever 31.5 TLR2 MEFV IL1B CXCL8 CRP
9 cervical adenitis 31.4 SPAG7 MEFV IL1B CRP CARD8
10 exanthem 31.2 IL1B CXCL8 CSF2 CRP
11 laryngitis 31.0 IL1B CXCL8 CRP
12 brucellosis 31.0 MEFV CXCL8 CRP
13 rheumatic heart disease 31.0 TLR2 MYOM2 IL1B HLA-DRB1
14 scarlet fever 30.9 MYOM2 IL1B CRP
15 common cold 30.9 IL1B CXCL8 CSF2 CRP
16 chlamydia 30.7 TLR2 IL1B CXCL8 CSF2 CRP
17 otitis media 30.7 TLR2 TLR1 LACTB IL1B CXCL8 CRP
18 tracheitis 30.7 IL1B CXCL8 CRP
19 toxic shock syndrome 30.7 TLR2 MYOM2 IL1B CXCL8 CRP
20 apnea, obstructive sleep 30.6 IL1B CXCL8 CRP
21 esophagitis 30.6 PTGS2 IL1B CXCL8
22 pain agnosia 30.6 PTGS2 IL1B CRP
23 haemophilus influenzae 30.6 TLR2 LACTB IL1B CXCL8
24 kawasaki disease 30.6 TLR2 FCGR1A CRP
25 bronchitis 30.6 TLR2 LACTB IL1B CXCL8 CRP
26 epiglottitis 30.5 LACTB CRP
27 periodic fever, familial, autosomal dominant 30.4 MEFV IL1B CRP
28 viral infectious disease 30.4 TLR2 TLR1 IL1B CXCL8
29 respiratory failure 30.4 IL1B CXCL8 CSF2 CRP
30 mediastinitis 30.4 LACTB CRP
31 appendicitis 30.4 IL1B CXCL8 CRP
32 pyoderma 30.4 MYOM2 MEFV IL1B CXCL8 CRP
33 gingivitis 30.3 TLR2 IL1B CXCL8
34 adult-onset still's disease 30.3 MEFV IL1B CRP
35 urinary tract infection 30.3 TLR2 IL1B CXCL8 CRP
36 gastroesophageal reflux 30.3 PTGS2 IL1B HLA-DRB1 CXCL8
37 juvenile rheumatoid arthritis 30.3 IL1B HLA-DRB1 CRP
38 cellulitis 30.3 MYOM2 LACTB IL1B CXCL8 CSF2 CRP
39 vasculitis 30.2 MEFV IL1B HLA-DRB1 CXCL8 CRP
40 neutropenia 30.2 IL1B FCGR1A CXCL8 CSF2 CRP
41 thyroiditis 30.2 IL1B HLA-DRB1 CRP
42 necrotizing fasciitis 30.2 MYOM2 IL1B CXCL8 CRP
43 syphilis 30.2 TLR2 LACTB HLA-DRB1 CRP
44 pulmonary tuberculosis 30.2 TLR2 IL1B HLA-DRB1 CRP
45 submandibular adenitis 30.2 MEFV FCGR1A
46 endocarditis 30.2 TLR2 LACTB CXCL8 CRP
47 urethritis 30.2 TLR2 IL1B CXCL8 CRP
48 urticaria 30.2 PTGS2 IL1B CXCL8 CRP
49 intracranial abscess 30.2 LACTB CRP
50 sleep apnea 30.1 IL1B CXCL8 CRP

Comorbidity relations with Pharyngitis via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Anxiety
Bronchitis Deficiency Anemia
Esophagitis Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Laryngitis
Oral Candidiasis Swallowing Disorders

Graphical network of the top 20 diseases related to Pharyngitis:



Diseases related to Pharyngitis

Symptoms & Phenotypes for Pharyngitis

UMLS symptoms related to Pharyngitis:


recurrent pharyngitis; sore throat; acute sore throat nos; throat irritation

MGI Mouse Phenotypes related to Pharyngitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 ADH5 CRP CSF2 FCGR1A IL1B LGALS3

Drugs & Therapeutics for Pharyngitis

Drugs for Pharyngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 183)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenoxymethylpenicillin Approved, Vet_approved Phase 4 87-08-1 6869
2
Tyrothricin Approved Phase 4 1404-88-2
3
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
4
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
7
Acetaminophen Approved Phase 4 103-90-2 1983
8
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
9
Nimesulide Approved, Investigational, Withdrawn Phase 4 51803-78-2 4495
10
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
11
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
12
Menthol Approved, Experimental Phase 4 1490-04-6, 2216-51-5, 15356-60-2 1254 16666 165675
13
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 4 55-56-1 2713 9552079
14
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
15
Acetylsalicylic acid Approved, Vet_approved Phase 4 50-78-2 2244
16
Benzydamine Approved Phase 4 642-72-8 12555
17
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
18
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
19
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
20
Lysine Approved, Nutraceutical Phase 4 56-87-1 5962
21
Tinoridine Investigational Phase 4 24237-54-5
22 Penicillins Phase 4
23 Antibiotics, Antitubercular Phase 4
24 Cyclooxygenase 2 Inhibitors Phase 4
25 Benzalkonium Compounds Phase 4
26 Anesthetics, Local Phase 4
27 Anti-Infective Agents, Local Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29 Antiemetics Phase 4
30 BB 1101 Phase 4
31 Gastrointestinal Agents Phase 4
32 Anti-Arrhythmia Agents Phase 4
33 Sodium Channel Blockers Phase 4
34 Diuretics, Potassium Sparing Phase 4
35 Disinfectants Phase 4
36 Chlorhexidine gluconate Phase 4
37 Ketoprofen lysine Phase 4
38 Dermatologic Agents Phase 4
39 HIV Protease Inhibitors Phase 4
40
protease inhibitors Phase 4
41 Dexketoprofen trometamol Phase 4
42
Ketorolac Tromethamine Phase 4
43 Anesthetics Phase 4
44 Antipyretics Phase 4
45 Fibrinolytic Agents Phase 4
46 Platelet Aggregation Inhibitors Phase 4
47 Analgesics, Opioid Phase 4
48 Narcotics Phase 4
49 Anti-Bacterial Agents Phase 4
50 Anti-Infective Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 199)
# Name Status NCT ID Phase Drugs
1 Group A Streptococcal Pharyngitis: Six Days Amoxicillin, oR Six Days Placebo in Children Between 3 and 15 Years Old:a Randomized, Double Blinded, Multicentred, Non-inferiority Trial Unknown status NCT03264911 Phase 4 Amoxicillin or Placebo
2 Tablet vs. Liquid Suspension Ibuprofen in the Relief of Pain Unknown status NCT01681667 Phase 4 Ibuprofen
3 Comparison of Two Induction Regimens Using Topical Lidocaine or Muscle Relaxant; Impact on Postoperative Sore Throat and Haemodynamics Unknown status NCT03031808 Phase 4 Lidocaine spray (2%);Muscle Relaxant (Rocuronium)
4 Effect on Postoperative Sore Throat of Lidocaine Jelly Application Over the Endotracheal Tube of Tapered-shaped Cuff Unknown status NCT02952157 Phase 4 Lidocaine jelly application;Normal saline application
5 A Randomized Controlled Clinical Trial of Streptococcus Group A-negative Acute Tonsillitis in Primary Health Care - a Comparison of Phenoxymethylpenicillin and no Antibiotic Treatment Unknown status NCT04083417 Phase 4 Phenoxymethylpenicillin
6 A Multi-centre, Randomized, Placebo-controlled, Double-blind, Parallel-group Study Investigating Safety and Efficacy of a Sore Throat Lozenge in the Symptomatic Treatment of Patients With Acute Pharyngitis Completed NCT03323528 Phase 4 Benzalkonium Chloride-Benzocaine Topical;Placebo Oral Tablet
7 Safety and Efficacy of Tinoridine in the Treatment of Pain and Inflammation in Patients With Acute Tonsillitis and/or Acute Pharyngitis: a Randomized, Double-blind Study Versus Placebo Completed NCT01224756 Phase 4 Tinoridine HCl;Placebo
8 Randomized, Open-label, Controlled Trial to Assess the Clinical Efficacy and Safety of Meloxicam Suspension 0.25 mg/kg/Day Once a Day, Versus Diclofenac 1 mg/kg/Day Twice a Day or Nimesulide 4 mg/kg/Day Twice a Day, for Five Days in the Treatment of Patients With Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis Completed NCT02229747 Phase 4 Meloxicam;Diclofenac;Nimesulide
9 Recurrent Throat Infections and Tonsillectomy Completed NCT00547391 Phase 4
10 Double-blind, Randomized, Placebo-controlled, Single Dose, Parallel Group Study Evaluating Efficacy and Safety of 1000 mg Acetylsalicylic Acid and 1000 mg Paracetamol in Adult Patients With Sore Throat Associated With a Common Cold Completed NCT01465009 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Paracetamol;Placebo
11 MISTRAL (Mouthwash In Sore Throat Relief: Antiinflammatory vs. Local Anesthetic Therapy) "Efficacy and Tolerability of Ketoprofen Lysine Salt as a Mouthwash in Acute Phlogosis of the Pharyngeal Cavity; Multicentre, Randomized, Single-blind, Parallel-group Comparison Versus Benzidamine Hydrochloride" Completed NCT02178293 Phase 4 Benzidamine hydrochloride;Ketoprofen lysine salt
12 Impact of Four Patient Information Leaflets (PIL) on Patient Behaviour : a Randomised Controlled Trial in Primary Care. Completed NCT01398696 Phase 4
13 Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies in the Non-complicated Acute Respiratory Tract Infections in General Practice Completed NCT01363531 Phase 4
14 Open Clinical Trial to Assess Safety and Efficacy of the Sore Throat Lozenges in Patients With Acute Sore Throats Completed NCT04139681 Phase 4 A. Vogels Sore Throat lozenges
15 Comparison Between Xylocaine Gel as Endotracheal Cuff Lubricant Versus Dexamethasone 8 mg Intravenously or Both for Sore Throat Prevention Following Intubation: Interventional Study Completed NCT02682134 Phase 4 xylocaine;Dexamethasone;Xylocaine and Dexamethasone
16 Combined Effect of Intravenous Lidocaine and Dexamethasone on Postoperative Sore Throat, Cough and Hoarseness. A Randomized Controlled Trial Completed NCT01990781 Phase 4 LD: Lidocaine and dexamethasone;L:Lidocaine;D: Dexamethasone;N: Normal saline (placebo)
17 Effect of Benzydamine Hydrochloride to Postoperative Sore Throat in Pediatric Patients: a Randomized Controlled Trial Completed NCT03074968 Phase 4 Benzydamine Hydrochloride;Normal saline
18 Comparison of the Efficacy of Intravenous Dexketoprofen and Paracetamol in the Treatment of Pain in Patients Presenting to the Emergency Department With Sore Throat: A Double-Blinded, Randomized, Controlled Trial Completed NCT03768882 Phase 4 paracetamol;Dexketoprofen
19 Comparing the Efficacies Between the Spray of S.L. Spray Solution and Difflam and Acular to Release Postoperative Sore Throat Completed NCT02608788 Phase 4 S.L.®;Difflam Forte ®;Acular®;placebo
20 Phase IV Study Comparing the Efficacy and Safety of Benzydamine Hydrochloride 0,3% Oromucosal Spray and Benzydamine Hydrochloride 3 mg Lozenges in Patients With Acute Sore Throat Completed NCT04941976 Phase 4 0.3% benzydamine hydrochloride spray oromucosal solution;Single 3 mg lozenge of benzydamine hydrochloride (mint flavour)
21 The Effect Of Two Packing Types For Throat Pain And Postoperative Nausea And Vomiting During Maxillofacial Surgery Completed NCT03574246 Phase 4 chlorhexidine gluconate %0,12 benzydamine hydrochloride %0,15
22 The Effect of Systemic Prophylactic Dexamethasone on the Incidence of Postoperative Sore Throat in Patients Undergoing Ambulatory Laparoscopic Gynecologic Surgery: A Prospective, Randomized, Double Blinded, Placebo Controlled Trial Completed NCT01052038 Phase 4 Placebo administration;Dexamethasone 0.05mg/kr administration;Dexamethasone 0.1mg/kg
23 ''Comparison of Preoperative Aspirin and Benzydamine Hydrochloride Gargles on Reduction in Severity and Duration of Post-Operative Sore Throat. A Randomized Controlled Parallel Study.'' Recruiting NCT05343429 Phase 4 Benzydamine hydrochloride;Aspirin
24 Effect of Tramadol on Postoperative Sore Throat in Thyroid Surgery Under General Anesthesia With Endotracheal Intubation: A Randomized Controlled Trial Recruiting NCT04991493 Phase 4 Tramadol hydrochloride
25 Efficacy of K-Y Jelly in Prevention of Postoperative Sore Throat After Nasal Surgery Recruiting NCT05436743 Phase 4 K-Y Jelly, Topical Gel soaked packs
26 Local, Phase IV, Multicenter, Double-blind, Randomized, Parallel, With Two Treatment Arms, Placebo-controlled Study to Evaluate the Reduction of Inflammatory Symptoms in the Treatment of Bacterial Pharyngitis With Ketoprofen and Amoxicillin in Pediatric Patients. Terminated NCT00799838 Phase 4 Ketoprofen;Placebo (for Ketoprofen);Amoxicillin
27 Does Beclomethasone Instillation Above the Cuff of Endotracheal Tubes Decrease the Occurrence of Postoperative Sore Throat? A Randomized Controlled Trial Withdrawn NCT02687100 Phase 4 Beclomethasone;Placebo
28 Efficacy of Benzydamine Hydrochloride Dripping at Endotracheal Tube Cuff for Prevention of Postoperative Sore Throat Unknown status NCT01637883 Phase 3 benzydamine HCl
29 A DOUBLE BLIND, RANDOMIZED, PLACEBO-CONTROLLED COMPARISON OF THE EFFICACY, SAFETY, AND TOLERABILITY OF CELECOXIB 100-150 MG, INCLUDING INITIAL DOSES OF 50 AND 100 MG, AND PLACEBO IN THE SYMPTOMATIC TREATMENT OF PATIENTS WITH PAINFUL PHARYNGITIS Completed NCT00402987 Phase 3 Celecoxib;celecoxib;placebo
30 Clinical Protocol For A Double-Blind, Randomized, Placebo-Controlled Comparison Of The Efficacy, Safety, And Tolerability Of Bextra® (Valdecoxib) 20 Mg Twice Daily, Bextra® 40 Mg Once Daily, And Placebo In The Symptomatic Treatment Of Subjects With Pharyngitis Completed NCT00647829 Phase 3 valdecoxib;placebo
31 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial Of Azithromycin SR Versus Amoxicillin For The Treatment Of Group A Β-Hemolytic Streptococcal Pharyngitis/Tonsillitis In Children Completed NCT00643149 Phase 3 amoxicillin;azithromycin SR
32 Double-blind, Randomized, Placebo-controlled Trial to Investigate the Efficacy and Tolerance of Ambroxol Lozenges 20 mg in the Treatment of Sore Throat in Patients With Acute Viral Pharyngitis Completed NCT00525044 Phase 3 Ambroxol;Placebo
33 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin SR Versus Three-Day Azithromycin for the Treatment of Group A β-Hemolytic Streptococcal Pharyngitis/Tonsillitis in Adolescents and Adults Completed NCT00644293 Phase 3 azithromycin (Zithromax);placebo;azithromycin SR
34 Open-Label, Randomized, Active Controlled, Single Arm, Study to Ensure the Efficacy and Safety of Medistus Antivirus Lozenges in Mild to Moderate Acute Pharyngitis or Sore Throat or Strep Throat. Completed NCT04612829 Phase 2, Phase 3
35 A Randomised, Double-blind, Placebo Controlled, Parallel Group, Multicentre Trial to Assess the Efficacy and Safety of Ambroxol Lozenges 20 mg (Hard Boiled Lozenges) Versus Placebo for the Relief of Sore Throat Pain in Patients With Acute Pharyngitis Completed NCT03583658 Phase 3 ambroxol BIH1526;placebo
36 Inhaled Glucocorticoids for Acute Pharyngitis: A Randomized Clinical Trial Completed NCT04027322 Phase 2, Phase 3 Budesonide 0.25 MG/ML Inhalant Solution;Dexamethasone;Normal saline
37 Efficacy and Tolerability of Ambroxol Lozenges 20mg in Relieving the Pain of Sore Throat in Adolescent Patients With Acute Viral Pharyngitis - A Randomised, Double-blind, Placebo-controlled Parallel Group Study. AMBROSIA: Ambroxol Lozenges In Sore Throat In Adolescents Completed NCT00144274 Phase 3 Ambroxol Lozenge
38 Comparison of Treatment Satisfaction and Treatment Adherence of a Novel Application Form "Dose Sipping Technology" (DST) of Oral Clarithromycin vs. Clarithromycin Syrup in Children Suffering From Acute Otitis Media, Tonsillitis, Pharyngitis, or Acute Bacterial Bronchitis (DoSe iT) Completed NCT04016051 Phase 3 Clarithromycin DST (125 mg);Clarithromycin DST (187.5 mg);Clarithromycin DST (250 mg);Clarithromycin Syrup (125 mg);Clarithromycin Syrup (187.5 mg);Clarithromycin Syrup (250 mg)
39 A Repeat-Dose, Multi-Centre, Randomized, Double-Blind, Placebo-Controlled, Study to Determine the Safety and Efficacy of Flurbiprofen 8.75 mg Lozenge Compared to Its Vehicle Control Lozenge in Patients With Painful Pharyngitis Completed NCT01048866 Phase 3 placebo;flurbiprofen;acetaminophen 650mg
40 A Phase III, Multicenter Study to Evaluate the Safety/Efficacy of APC-111 MP Tablet QD vs. Penicillin VK QID Both for 10 Days Treatment of Pharyngitis Secondary to S.Pyogenes in Adolescents/Adults Completed NCT00242281 Phase 3 APC-111 MP Tablet, 775 mg
41 A Randomized, Double-Blind, Placebo-Controlled Multiple-Dose Study to Determine the Efficacy, Onset, and Duration of Action of Flurbiprofen 8.75 mg Lozenge Compared to Its Vehicle Control Lozenge in Patients With Painful Pharyngitis Completed NCT01049334 Phase 3 Placebo;Flurbiprofen
42 Efficacy and Tolerability of Ambroxol Lozenge 20 mg in Relieving Pain of Sore Throat in Patients With Acute Viral Pharyngitis-A Randomised, Double-blind,Placebo- and Active-controlled Parallel Group Study Completed NCT00148499 Phase 3 Ambroxol hydrochloride (Mucoangin?);benzocaine
43 A Single-Dose, Randomized, Double-Blind, Placebo-Controlled Onset-of-Action Study Utilizing the Double-Stopwatch Method Completed NCT01986361 Phase 3 flurbiprofen;placebo
44 Multicentric Randomized Double Blind Double Dummy Placebo Controlled Clinical Trial for Assessment of Safety and Efficacy of a Echinacea/Sage Spray in Comparison to a Chlorhexidine/Lidocaine Spray in the Treatment of Acute Sore Throats Completed NCT00707902 Phase 3 chlorhexidine/lidocaine;echinacea/sage
45 A Pivotal, Placebo Controlled, Phase III Study to Compare Efficacy and Tolerability of a Fixed Combination, Containing 500 mg ASA and 30 mg Pseudoephedrine, in Comparison to Its Single Components in Patients With Sore Throat and Nasal Congestion Completed NCT01062360 Phase 3 Acetylsalicylic Acid (Aspirin Complex, BAYE4465) + Pseudoephedrine;Acetylsalicylic Acid (Aspirin, BAYE4465);Pseudoephedrine;Placebo
46 A Phase III, Investigator Blind, Randomized, Multicenter Study to Evaluate the Efficacy and Safety of APC-231 Sprinkle QD for 7 Days vs Penicillin VK 10 mg/kg QID for 10 Days in Pediatric Patients With Streptococcus Pyogenes Completed NCT00100126 Phase 3 Amoxicillin Pulsatile Release Multiparticluate Sprinkle
47 A Phase III, Randomized, Double-Blind, Double-Dummy Multicenter Study to Evaluate the Efficacy and Safety of 775 mg APC-111 MP Tablet QD for 7 Days vs Penicillin VK 250 mg QID for 10 Days in Patients With Streptococcus Pyogenes Completed NCT00095368 Phase 3 Amoxicillin Pulsatile Release Multiparticulate Tablet (drug)
48 A Randomized Clinical Trial to Improve Prescribing Patterns in Ambulatory Pediatrics Completed NCT00368823 Phase 3
49 Onset of Action of a Fast Release Aspirin Tablet and Acetaminophen Caplet in Sore Throat Pain Completed NCT01453400 Phase 3 Acetylsalicylic Acid (Aspirin, BAY1019036) + placebo;Acetaminophen + placebo;Placebo
50 A 4-arm, Multicenter, Randomized, Double-blind, Placebo- and Active-controlled, Single Dose, Parallel Group Study Comparing Efficacy and Safety of a Fixed Combination of 500 mg Acetylsalicylic Acid + 4 mg Lidocaine With 500 mg Acetylsalicylic Acid and 4 mg Lidocaine Monotherapy as Well as Placebo in Adult Patients With Sore Throat Associated With a Common Cold. Completed NCT01361399 Phase 3 Acetylsalicylic acid (Aspirin, BAYE4465) & Lidocain;Acetylsalicylic Acid (Aspirin, BAYE4465);Lidocain;Placebo

Search NIH Clinical Center for Pharyngitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


cefditoren
Guaifenesin

Cochrane evidence based reviews: pharyngitis

Genetic Tests for Pharyngitis

Anatomical Context for Pharyngitis

Organs/tissues related to Pharyngitis:

MalaCards : Thyroid, Heart, Tonsil, Lymph Node, Skin, T Cells, Lung

Publications for Pharyngitis

Articles related to Pharyngitis:

(show top 50) (show all 6444)
# Title Authors PMID Year
1
The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. 46
21098571 2010
2
Potential mechanisms for failure to eradicate group A streptococci from the pharynx. 53 62
10506234 1999
3
Phenoxymethyl penicillin versus co-amoxiclav in the treatment of acute streptococcal pharyngitis, and the role of beta-lactamase activity in saliva. 53 62
8647754 1996
4
Treatment of beta-hemolytic streptococcal pharyngitis with cefaclor or penicillin. Efficacy and interaction with beta-lactamase-producing organisms in the pharynx. 53 62
1990041 1991
5
Lack of influence of beta-lactamase-producing flora on recovery of group A streptococci after treatment of acute pharyngitis. 53 62
2123240 1990
6
The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathway. 62
36152783 2023
7
Trends in Emergency Department Computed Tomography Usage for Diagnosis of Peritonsillar Abscess. 62
33433233 2023
8
23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways. 62
36115602 2023
9
Resibufogenin, one of bufadienolides in toad venom, suppresses LPS-induced inflammation via inhibiting NF-κB and AP-1 pathways. 62
36252491 2022
10
Nonsteroidal anti-inflammatory drugs and pharyngitis. 62
36444626 2022
11
Use of Host Response to Refine the Diagnosis of Group A Streptococcal Pharyngitis. 62
36153766 2022
12
Detection of group A streptococcus in children with confirmed viral pharyngitis and antiviral host response. 62
36163516 2022
13
Monkeypox in humans: a new outbreak. 62
35785957 2022
14
Acute kidney injury in group A streptococcal bacteraemia: incidence, outcome and predictive value of C-reactive protein. 62
36047611 2022
15
Macromolecular crowding agents enhance the sensitivity of lateral flow immunoassays. 62
36183582 2022
16
Pediatric Antibiotic Prescribing and Utilization Practices for RTIs at Private Urgent Care Centers. 62
35762069 2022
17
Antioxidant, anti-inflammatory and analgesic activity of Mimosa acutistipula (Mart.) Benth. 62
36436717 2022
18
Argon Plasma Coagulation of Gastric Inlet Patches of the Cervical Esophagus Relieves Vocal and Respiratory Symptoms in Selected Patients. 62
36376579 2022
19
Upper Airway Manifestations of Monkeypox: A Case Report and Literature Review. 62
36383119 2022
20
Evolution of throat symptoms during the COVID-19 pandemic in the US. 62
35976290 2022
21
Performance of a Molecular Test for Group A Streptococcus Pharyngitis. 62
36322677 2022
22
Factors influencing receipt of an antibiotic prescription among insured patients in Tanzania: a cross-sectional study. 62
36332955 2022
23
Cooccurrence of Alport syndrome and poststreptococcal acute glomerulonephritis with improvement after steroid administration. 62
35397771 2022
24
High risk and low prevalence diseases: Lemierre's syndrome. 62
36058204 2022
25
International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat. 62
36419002 2022
26
Adverse events of biological therapy in chronic rhinosinusitis with nasal polyps: A systematic review. 62
36057193 2022
27
Shufeng Jiedu capsule inhibits inflammation and apoptosis by activating A2AAR and inhibiting NF-κB to alleviate LPS-induced ALI. 62
36002086 2022
28
Does having MEFV gene sequence variants affect the clinical course and colchicine response in children with PFAPA syndrome? 62
36376520 2022
29
Comparative Safety and Attributable Health Care Expenditures Following Inappropriate versus Appropriate Outpatient Antibiotic Prescriptions among Adults with Upper Respiratory Infections. 62
36350187 2022
30
Severe abacavir hypersensitivity reaction in a patient with human immunodeficiency virus infection: a case report. 62
36345015 2022
31
Alpha-1-antitrypsin in serum exosomes and pericardial fluid exosomes is associated with severity of rheumatic heart disease. 62
36318408 2022
32
Obstetric Care for Monkey Pox in India: What Every Clinician Should Know. 62
36458066 2022
33
Monkeypox in a Patient with Controlled HIV Infection Initially Presenting with Fever, Painful Pharyngitis, and Tonsillitis. 62
36295570 2022
34
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019. 62
35995133 2022
35
Case Report: Bloodstream Infection with Toxigenic Corynebacterium diphtheriae and Gram-Negative Sepsis in a Child with Burns. 62
36037863 2022
36
Synchronous disease onset and flares in siblings with PFAPA. 62
36199113 2022
37
Bilateral upper eyelid swelling (Hoagland sign) in Epstein-Barr infectious mononucleosis: prospective experience. 62
36224451 2022
38
Two cases of EBV infection preceding lymphoma. 62
35732965 2022
39
[Acute sore throat, not always innocent]. 62
36300468 2022
40
Point-of-care ultrasound in the head and neck region. 62
36284028 2022
41
Monoclonal antibody treatment of COVID-19 in a pregnant woman with common variable immunodeficiency. 62
36244996 2022
42
Monkeypox and HIV in the Canary Islands: A Different Pattern in a Mobile Population. 62
36288059 2022
43
Retrospective study on the effectiveness and safety of the shortened 5- to 7-day antibiotic regimen for acute streptococcal pharyngotonsillitis compared to the classic 10-day regimen. 62
36302708 2022
44
Steroidal saponins profiling of Rohdea chinensis (Baker) N.Tanaka by high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry. 62
36190791 2022
45
A systematic review and clinical atlas on mucocutaneous presentations of monkeypox: with a comprehensive approach to all aspects of the new and previous monkeypox outbreaks. 62
36254380 2022
46
Standardizing Strep Throat Documentation in a Pediatric Outpatient Setting During COVID-19: A Quality Improvement Pilot Project. 62
36277114 2022
47
Molecular point-of-care testing in the community pharmacy setting: current status and future prospects. 62
36269237 2022
48
Prescribing for different antibiotic classes across age groups in the Kaiser Permanente Northern California population in association with influenza incidence, 2010-2018. 62
36285506 2022
49
A multicenter survey on the current status of chronic cough and its impact on quality of life in Guangdong, China. 62
36245630 2022
50
Bactericidal Activity of Carvacrol against Streptococcus pyogenes Involves Alteration of Membrane Fluidity and Integrity through Interaction with Membrane Phospholipids. 62
36297428 2022

Variations for Pharyngitis

Expression for Pharyngitis

Search GEO for disease gene expression data for Pharyngitis.

Pathways for Pharyngitis

Pathways related to Pharyngitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 TLR2 TLR1 PTGS2 PIK3AP1 MEFV LGALS3
2
Show member pathways
12.35 TLR2 TLR1 IL1B CXCL8
3 12.35 TLR2 TLR1 PTGS2 LGALS3 IL1B
4
Show member pathways
12.26 TLR2 TLR1 IL1B CXCL8
5
Show member pathways
12.07 TLR2 PTGS2 CXCL8 CSF2
6 11.81 PTGS2 IL1B CXCL8
7
Show member pathways
11.77 TLR2 TLR1 IL1B
8 11.77 PTGS2 LGALS3 IL1B CXCL8
9 11.73 IL1B HLA-DRB1 CXCL8
10
Show member pathways
11.71 TLR2 TLR1 IL1B
11
Show member pathways
11.6 HLA-DRB1 CXCL8 CRP
12 11.57 IL1B CSF2 CD1A
13
Show member pathways
11.51 PTGS2 CXCL8 CSF2
14 11.47 IL1B CXCL8 CSF2
15
Show member pathways
11.26 CSF2 CXCL8 IL1B PTGS2
16 11.25 CARD8 IL1B MEFV
17 11.01 IL1B HLA-DRB1 CSF2
18 10.88 TLR2 TLR1 IL1B
19 10.71 PTGS2 CXCL8 CRP
20
Show member pathways
10.61 LGALS3 CSF2
21 10.6 PTGS2 IL1B CXCL8 CSF2

GO Terms for Pharyngitis

Cellular components related to Pharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.92 TLR2 TLR1

Biological processes related to Pharyngitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.13 CARD8 CRP FCGR1A LGALS3 MEFV SPON2
2 positive regulation of interleukin-6 production GO:0032755 10.06 TLR2 TLR1 SPON2 IL1B
3 immune response GO:0006955 10.03 TLR2 TLR1 IL1B HLA-DRB1 FCGR1A CXCL8
4 response to lipopolysaccharide GO:0032496 9.97 TLR2 SPON2 PTGS2 IL1B ADH5
5 inflammatory response GO:0006954 9.86 CARD8 CRP CXCL8 IL1B MEFV PTGS2
6 positive regulation of prostaglandin biosynthetic process GO:0031394 9.83 PTGS2 IL1B
7 toll-like receptor 2 signaling pathway GO:0034134 9.81 TLR2 PIK3AP1
8 cellular response to bacterial lipopeptide GO:0071221 9.8 TLR2 TLR1
9 positive regulation of fever generation GO:0031622 9.78 PTGS2 IL1B
10 cellular response to triacyl bacterial lipopeptide GO:0071727 9.73 TLR1 TLR2
11 detection of triacyl bacterial lipopeptide GO:0042495 9.71 TLR2 TLR1
12 response to external stimulus GO:0009605 9.5 TLR2 TLR1 CXCL8
13 immune system process GO:0002376 9.28 TLR2 TLR1 SPON2 MEFV LGALS3 HLA-DRB1

Molecular functions related to Pharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.02 TLR2 TLR1 CD1A

Sources for Pharyngitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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