MCID: PHR003
MIFTS: 57

Pharyngitis

Categories: Oral diseases, Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Pharyngitis

MalaCards integrated aliases for Pharyngitis:

Name: Pharyngitis 12 74 54 43 15 71
Acute Pharyngitis 12 17 71 32
Chronic Pharyngitis 12 71 32
Pharyngeal Diseases 43 71
Chronic Pharyngitis and Nasopharyngitis 12
Chronic Pharyn/nasopharyngitis 12
Persistent Sore Throat 12
Sore Throat - Chronic 12
Chronic Sore Throat 12
Pharyngeal Disorder 12
Pharyngitis - Acute 12
Pharyngeal Disease 12
Acute Sore Throat 12
Inflamed Throat 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2275
ICD9CM 34 462 472 478.20
UMLS 71 C0001344 C0031345 C0031350 more

Summaries for Pharyngitis

Disease Ontology : 12 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as sore throat. The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.

MalaCards based summary : Pharyngitis, also known as acute pharyngitis, is related to tonsillitis and cyclic neutropenia, and has symptoms including recurrent pharyngitis, sore throat and acute sore throat nos. An important gene associated with Pharyngitis is MIR452 (MicroRNA 452), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Chlorhexidine and Benzydamine have been mentioned in the context of this disorder. Affiliated tissues include testes, tonsil and heart.

Wikipedia : 74 Pharyngitis is inflammation of the back of the throat, known as the pharynx. It typically results in a... more...

Related Diseases for Pharyngitis

Diseases related to Pharyngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1128)
# Related Disease Score Top Affiliating Genes
1 tonsillitis 33.0 LACTB IL1B CXCL8
2 cyclic neutropenia 32.8 IL1B CXCL8 CSF2
3 rheumatic fever 32.8 MYOM2 HLA-DRB1 CD40LG
4 acute proliferative glomerulonephritis 32.6 CRP CD40LG CD4
5 necrotizing ulcerative gingivitis 32.3 CD40LG CD4
6 sleep apnea 31.6 IL1B CXCL8 CRP
7 haemophilus influenzae 31.5 LACTB CXCL8
8 apnea, obstructive sleep 31.4 IL1B CXCL8 CRP
9 aspiration pneumonia 31.2 LACTB CRP CD40LG
10 chlamydia 31.2 IL1B CXCL8 CSF2 CRP CD40LG
11 laryngitis 31.1 IL1B CRP CD40LG
12 rheumatic heart disease 31.1 MYOM2 IL1B HLA-DRB1
13 aphthous stomatitis 31.1 NLRP3 MEFV IL1B FCGR1A CXCL8 CSF2
14 otitis media 31.0 LACTB IL1B CXCL8 CRP CD40LG
15 esophagitis 31.0 PTGS2 IL1B CXCL8
16 streptococcal toxic-shock syndrome 30.9 MYOM2 CXCL8
17 fasciitis 30.9 MYOM2 CXCL8 CRP
18 osteomyelitis 30.9 NLRP3 IL1B CXCL8
19 epiglottitis 30.8 LACTB CRP CD40LG
20 scarlet fever 30.8 MYOM2 ETV5 CRP CD40LG
21 brucellosis 30.7 MEFV CXCL8 CRP CD40LG
22 lymphadenitis 30.7 IL1B CXCL8 CRP CD4
23 toxic shock syndrome 30.7 MYOM2 IL1B CXCL8 CRP CD40LG
24 candidiasis 30.7 IL1B CXCL8 CSF2 CD40LG
25 stomatitis 30.6 NLRP3 MEFV IL1B CXCL8 CSF2 CD40LG
26 pleural empyema 30.6 CRP CD40LG CD4
27 bursitis 30.6 PTGS2 IL1B CRP
28 cellulitis 30.5 IL1B CRP CD40LG CD4
29 appendicitis 30.5 IL1B CXCL8 CRP
30 tularemia 30.5 IL1B CD40LG CD4
31 chickenpox 30.5 CRP CD40LG CD4
32 endocarditis 30.5 LACTB CXCL8 CRP
33 bronchitis 30.5 LACTB IL1B CXCL8 CRP CD40LG
34 common cold 30.4 IL1B CXCL8 CSF2 CD4
35 cervicitis 30.4 IL1B CXCL8 CD4
36 syphilis 30.4 HLA-DRB1 CRP CD40LG CD4
37 respiratory failure 30.4 IL1B CXCL8 CRP CD40LG CD4
38 kawasaki disease 30.3 IL1B CRP CD40LG CD4
39 septic arthritis 30.3 IL1B CXCL8 CRP
40 periodontitis 30.3 PTGS2 IL1B CXCL8 CRP
41 histoplasmosis 30.3 HLA-DRB1 CD40LG CD4
42 familial mediterranean fever 30.3 NLRP3 MVK MEFV IL1B CXCL8 CRP
43 diarrhea 30.3 MVK MEFV IL1B CXCL8 CD40LG
44 urethritis 30.3 IL1B CXCL8 CRP CD40LG CD4
45 necrotizing fasciitis 30.3 MYOM2 IL1B ETV5 CXCL8 CRP
46 submandibular adenitis 30.3 MEFV FCGR1A
47 purpura 30.3 MEFV CRP CD40LG
48 reactive arthritis 30.3 IL1B HLA-DRB1 CXCL8 CRP
49 chlamydia pneumonia 30.3 IL1B CXCL8 CRP CD40LG CD4
50 peptic ulcer disease 30.3 PTGS2 IL1B CXCL8

Comorbidity relations with Pharyngitis via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Anxiety
Bronchitis Deficiency Anemia
Esophagitis Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Laryngitis
Oral Candidiasis Swallowing Disorders

Graphical network of the top 20 diseases related to Pharyngitis:



Diseases related to Pharyngitis

Symptoms & Phenotypes for Pharyngitis

UMLS symptoms related to Pharyngitis:


recurrent pharyngitis, sore throat, acute sore throat nos, throat irritation

Drugs & Therapeutics for Pharyngitis

Drugs for Pharyngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 253)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
2
Benzydamine Approved Phase 4 100-46-9, 642-72-8 7504
3
Tyrothricin Approved Phase 4 1404-88-2
4
tannic acid Approved Phase 4 1401-55-4
5
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
8
Budesonide Approved Phase 4 51333-22-3 63006 5281004
9
Acetaminophen Approved Phase 4 103-90-2 1983
10
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
11
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
12
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
13
Fluconazole Approved, Investigational Phase 4 86386-73-4 3365
14
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
15
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
16
Clarithromycin Approved Phase 4 81103-11-9 84029
17
Pemetrexed Approved, Investigational Phase 4 137281-23-3, 150399-23-8 60843 446556
18
leucovorin Approved Phase 4 58-05-9 6006 143
19
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
20
Montelukast Approved Phase 4 158966-92-8 5281040
21
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
22
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
23
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
24
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
25
Menthol Approved Phase 4 2216-51-5 16666
26
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
27
Racepinephrine Approved Phase 4 329-65-7 838
28
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
29
Sotalol Approved Phase 4 3930-20-9, 959-24-0 5253
30
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
31
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
32
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
33
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
34 Tinoridine Investigational Phase 4 24237-54-5
35
Beclomethasone Phase 4 4419-39-0 20469
36 Chlorhexidine gluconate Phase 4
37 Benzalkonium Compounds Phase 4
38 Hormones Phase 4
39 Hormone Antagonists Phase 4
40 glucocorticoids Phase 4
41 Antiemetics Phase 4
42 Gastrointestinal Agents Phase 4
43 BB 1101 Phase 4
44 Antipyretics Phase 4
45 Platelet Aggregation Inhibitors Phase 4
46 Ketoprofen lysine Phase 4
47 lysine Phase 4
48 Fibrinolytic Agents Phase 4
49 Antifungal Agents Phase 4
50 Vitamin B Complex Phase 4

Interventional clinical trials:

(show top 50) (show all 224)
# Name Status NCT ID Phase Drugs
1 Group A Streptococcal Pharyngitis: Six Days Amoxicillin, oR Six Days Placebo in Children Between 3 and 15 Years Old:a Randomized, Double Blinded, Multicentred, Non-inferiority Trial Unknown status NCT03264911 Phase 4 Amoxicillin or Placebo
2 Effect on Postoperative Sore Throat of Lidocaine Jelly Application Over the Endotracheal Tube of Tapered-shaped Cuff Unknown status NCT02952157 Phase 4 Lidocaine jelly application;Normal saline application
3 Tablet vs. Liquid Suspension Ibuprofen in the Relief of Pain Unknown status NCT01681667 Phase 4 Ibuprofen
4 Does Beclomethasone Instillation Above the Cuff of Endotracheal Tubes Decrease the Occurrence of Postoperative Sore Throat? A Randomized Controlled Trial Unknown status NCT02687100 Phase 4 Beclomethasone;Placebo
5 Safety and Efficacy of Tinoridine in the Treatment of Pain and Inflammation in Patients With Acute Tonsillitis and/or Acute Pharyngitis: a Randomized, Double-blind Study Versus Placebo Completed NCT01224756 Phase 4 Tinoridine HCl;Placebo
6 A Multi-centre, Randomized, Placebo-controlled, Double-blind, Parallel-group Study Investigating Safety and Efficacy of a Sore Throat Lozenge in the Symptomatic Treatment of Patients With Acute Pharyngitis Completed NCT03323528 Phase 4 Benzalkonium Chloride-Benzocaine Topical;Placebo Oral Tablet
7 Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies in the Non-complicated Acute Respiratory Tract Infections in General Practice Completed NCT01363531 Phase 4
8 Multicenter, Open, Randomized Comparative Trial To Compare Bacteriological And Clinical Efficacy Of Azithromycin Versus Amoxicillin In Children With Streptococcus Tonsillitis Completed NCT00643539 Phase 4 Zithromax;Clamoxyl
9 Impact of Four Patient Information Leaflets (PIL) on Patient Behaviour : a Randomised Controlled Trial in Primary Care. Completed NCT01398696 Phase 4
10 MISTRAL (Mouthwash In Sore Throat Relief: Antiinflammatory vs. Local Anesthetic Therapy) "Efficacy and Tolerability of Ketoprofen Lysine Salt as a Mouthwash in Acute Phlogosis of the Pharyngeal Cavity; Multicentre, Randomized, Single-blind, Parallel-group Comparison Versus Benzidamine Hydrochloride" Completed NCT02178293 Phase 4 Benzidamine hydrochloride;Ketoprofen lysine salt
11 Randomized, Open-label, Controlled Trial to Assess the Clinical Efficacy and Safety of Meloxicam Suspension 0.25 mg/kg/Day Once a Day, Versus Diclofenac 1 mg/kg/Day Twice a Day or Nimesulide 4 mg/kg/Day Twice a Day, for Five Days in the Treatment of Patients With Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis Completed NCT02229747 Phase 4 Meloxicam;Diclofenac;Nimesulide
12 Recurrent Throat Infections and Tonsillectomy Completed NCT00547391 Phase 4
13 The Effect Of Two Packing Types For Throat Pain And Postoperative Nausea And Vomiting During Maxillofacial Surgery Completed NCT03574246 Phase 4 chlorhexidine gluconate %0,12 benzydamine hydrochloride %0,15
14 Comparison Between Xylocaine Gel as Endotracheal Cuff Lubricant Versus Dexamethasone 8 mg Intravenously or Both for Sore Throat Prevention Following Intubation: Interventional Study Completed NCT02682134 Phase 4 xylocaine;Dexamethasone;Xylocaine and Dexamethasone
15 Effect of Benzydamine Hydrochloride to Postoperative Sore Throat in Pediatric Patients: a Randomized Controlled Trial Completed NCT03074968 Phase 4 Benzydamine Hydrochloride;Normal saline
16 A Phase IV Randomized Study of the Use of Fluconazole as Chronic Suppressive Therapy Versus Episodic Therapy in HIV Positive Subjects With Recurrent Oropharyngeal Candidiasis Completed NCT00000951 Phase 4 Fluconazole
17 Combined Effect of Intravenous Lidocaine and Dexamethasone on Postoperative Sore Throat, Cough and Hoarseness. A Randomized Controlled Trial Completed NCT01990781 Phase 4 LD: Lidocaine and dexamethasone;L:Lidocaine;D: Dexamethasone;N: Normal saline (placebo)
18 Open-Label Single-Arm Phase IV Study of Pemetrexed in Taiwanese Patients With Advanced Non-Small Cell Lung Cancer Who Have Had Prior Chemotherapy Completed NCT00380718 Phase 4 pemetrexed
19 Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
20 Double-blind, Randomized, Placebo-controlled, Single Dose, Parallel Group Study Evaluating Efficacy and Safety of 1000 mg Acetylsalicylic Acid and 1000 mg Paracetamol in Adult Patients With Sore Throat Associated With a Common Cold Completed NCT01465009 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Paracetamol;Placebo
21 Role of Montelukast in Asthma and Allergic Rhinitis Patients Completed NCT03380975 Phase 4 Montelukast 10mg
22 Comparing the Efficacies Between the Spray of S.L. Spray Solution and Difflam and Acular to Release Postoperative Sore Throat Completed NCT02608788 Phase 4 S.L.®;Difflam Forte ®;Acular®;placebo
23 Comparison of the Efficacy of Intravenous Dexketoprofen and Paracetamol in the Treatment of Pain in Patients Presenting to the Emergency Department With Sore Throat: A Double-Blinded, Randomized, Controlled Trial Completed NCT03768882 Phase 4 paracetamol;Dexketoprofen
24 The Effect of Systemic Prophylactic Dexamethasone on the Incidence of Postoperative Sore Throat in Patients Undergoing Ambulatory Laparoscopic Gynecologic Surgery: A Prospective, Randomized, Double Blinded, Placebo Controlled Trial Completed NCT01052038 Phase 4 Placebo administration;Dexamethasone 0.05mg/kr administration;Dexamethasone 0.1mg/kg
25 TEAM (Trial on Efficacy and Quality of Life Among Asthmatic Patient With Montelukast) Completed NCT03096327 Phase 4 Montelukast;Placebo
26 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Completed NCT00560586 Phase 4 Budesonide;placebo
27 A Randomized Controlled Clinical Trial of Streptococcus Group A-negative Acute Tonsillitis in Primary Health Care - a Comparison of Phenoxymethylpenicillin and no Antibiotic Treatment Recruiting NCT04083417 Phase 4 Phenoxymethylpenicillin
28 Comparison of Two Induction Regimens Using Topical Lidocaine or Muscle Relaxant; Impact on Postoperative Sore Throat and Haemodynamics Recruiting NCT03031808 Phase 4 Lidocaine spray (2%);Muscle Relaxant (Rocuronium)
29 Randomized Clinical Trial Examining Use of Adjunct EXPAREL for Post-tonsillectomy Pain Management in Adults Active, not recruiting NCT03420638 Phase 4 Adjunct Exparel (bupivacaine liposome suspension 1.3%)
30 Open Clinical Trial to Assess Safety and Efficacy of the Sore Throat Lozenges in Patients With Acute Sore Throats Active, not recruiting NCT04139681 Phase 4 A. Vogels Sore Throat lozenges
31 A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Not yet recruiting NCT02347111 Phase 4 Flecainide;Sotalol
32 Local, Phase IV, Multicenter, Double-blind, Randomized, Parallel, With Two Treatment Arms, Placebo-controlled Study to Evaluate the Reduction of Inflammatory Symptoms in the Treatment of Bacterial Pharyngitis With Ketoprofen and Amoxicillin in Pediatric Patients. Terminated NCT00799838 Phase 4 Ketoprofen;Placebo (for Ketoprofen);Amoxicillin
33 A Multicenter, Single-blind, Randomized, Placebo-controlled Comparative Study on Efficacy and Safety of the Lysobact Complete Spray®, Tantum Verde® Spray and Pharyngal® Oromucosal Spray in the Treatment of Acute Sore Throat in Common Cold Unknown status NCT03282045 Phase 3 Lysobact Complete Sprey;Tantum Verde® Spray;Pharyngal® Oromucosal Spray;Placebo
34 Evaluation of Accuracy of Rapid Tests for Group A Beta Hemolytic Streptococci in Out-patients With Sore Throat From Acute Pharyngitis at Siriraj Hospital Unknown status NCT02623985 Phase 3
35 Efficacy of Benzydamine Hydrochloride Dripping at Endotracheal Tube Cuff for Prevention of Postoperative Sore Throat Unknown status NCT01637883 Phase 3 benzydamine HCl
36 Study of Efficacy and Safety of V0498 Versus Placebo in Acute Sore Throat Pain. Completed NCT01785862 Phase 3 Ibuprofen 25 mg;Placebo
37 Multicentric Randomized Double Blind Double Dummy Placebo Controlled Clinical Trial for Assessment of Safety and Efficacy of a Echinacea/Sage Spray in Comparison to a Chlorhexidine/Lidocaine Spray in the Treatment of Acute Sore Throats Completed NCT00707902 Phase 3 chlorhexidine/lidocaine;echinacea/sage
38 A Randomised, Double-blind, Placebo Controlled, Parallel Group, Multicentre Trial to Assess the Efficacy and Safety of Ambroxol Lozenges 20 mg (Hard Boiled Lozenges) Versus Placebo for the Relief of Sore Throat Pain in Patients With Acute Pharyngitis Completed NCT03583658 Phase 3 ambroxol BIH1526;placebo
39 A Single-Dose, Randomized, Double-Blind, Placebo-Controlled Onset-of-Action Study Utilizing the Double-Stopwatch Method Completed NCT01986361 Phase 3 flurbiprofen;placebo
40 A Randomized, Double-Blind, Placebo-Controlled Multiple-Dose Study to Determine the Efficacy, Onset, and Duration of Action of Flurbiprofen 8.75 mg Lozenge Compared to Its Vehicle Control Lozenge in Patients With Painful Pharyngitis Completed NCT01049334 Phase 3 Placebo;Flurbiprofen
41 A Repeat-Dose, Multi-Centre, Randomized, Double-Blind, Placebo-Controlled, Study to Determine the Safety and Efficacy of Flurbiprofen 8.75 mg Lozenge Compared to Its Vehicle Control Lozenge in Patients With Painful Pharyngitis Completed NCT01048866 Phase 3 placebo;flurbiprofen;acetaminophen 650mg
42 Prospective, Multicenter, Open, Randomized, Parallel, Clinical Study for Comparative Assessment of Efficacy and Safety of Angal S, Topical Spray [Menthol], 0,5 mg + 2 mg / 1 ml (Sandoz d.d., Slovenia), and ANTI-ANGIN® FORMULA, Topical Metered Spray, 0,12 mg + 0,24 mg / Dose (OOO "Valeant", Russia) in Treatment of Patients With Uncomplicated Acute Infectious and Inflammatory Diseases of the Pharynx, Accompanied by a Sore Throat Completed NCT03095508 Phase 3 Angal S, topical spray [Menthol];ANTI-ANGIN® FORMULA, topical metered spray
43 A Phase III, Investigator Blind, Randomized, Multicenter Study to Evaluate the Efficacy and Safety of APC-231 Sprinkle QD for 7 Days vs Penicillin VK 10 mg/kg QID for 10 Days in Pediatric Patients With Streptococcus Pyogenes Completed NCT00100126 Phase 3 Amoxicillin Pulsatile Release Multiparticluate Sprinkle
44 A Phase III, Randomized, Double-Blind, Double-Dummy Multicenter Study to Evaluate the Efficacy and Safety of 775 mg APC-111 MP Tablet QD for 7 Days vs Penicillin VK 250 mg QID for 10 Days in Patients With Streptococcus Pyogenes Completed NCT00095368 Phase 3 Amoxicillin Pulsatile Release Multiparticulate Tablet (drug)
45 A DOUBLE BLIND, RANDOMIZED, PLACEBO-CONTROLLED COMPARISON OF THE EFFICACY, SAFETY, AND TOLERABILITY OF CELECOXIB 100-150 MG, INCLUDING INITIAL DOSES OF 50 AND 100 MG, AND PLACEBO IN THE SYMPTOMATIC TREATMENT OF PATIENTS WITH PAINFUL PHARYNGITIS Completed NCT00402987 Phase 3 Celecoxib;Celecoxib;celecoxib;placebo
46 Efficacy and Tolerability of Ambroxol Lozenge 20 mg in Relieving Pain of Sore Throat in Patients With Acute Viral Pharyngitis-A Randomised, Double-blind,Placebo- and Active-controlled Parallel Group Study Completed NCT00148499 Phase 3 Ambroxol hydrochloride (Mucoangin?);benzocaine
47 Efficacy and Tolerability of Ambroxol Lozenges 20mg in Relieving the Pain of Sore Throat in Adolescent Patients With Acute Viral Pharyngitis - A Randomised, Double-blind, Placebo-controlled Parallel Group Study. AMBROSIA: Ambroxol Lozenges In Sore Throat In Adolescents Completed NCT00144274 Phase 3 Ambroxol Lozenge
48 A Phase III, Multicenter Study to Evaluate the Safety/Efficacy of APC-111 MP Tablet QD vs. Penicillin VK QID Both for 10 Days Treatment of Pharyngitis Secondary to S.Pyogenes in Adolescents/Adults Completed NCT00242281 Phase 3 APC-111 MP Tablet, 775 mg
49 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin SR Versus Three-Day Azithromycin for the Treatment of Group A β-Hemolytic Streptococcal Pharyngitis/Tonsillitis in Adolescents and Adults Completed NCT00644293 Phase 3 azithromycin (Zithromax);placebo;azithromycin SR;placebo
50 Onset of Action of a Fast Release Aspirin Tablet and Acetaminophen Caplet in Sore Throat Pain Completed NCT01453400 Phase 3 Acetylsalicylic Acid (Aspirin, BAY1019036) + placebo;Acetaminophen + placebo;Placebo

Search NIH Clinical Center for Pharyngitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


cefditoren
Guaifenesin

Cochrane evidence based reviews: pharyngitis

Genetic Tests for Pharyngitis

Anatomical Context for Pharyngitis

MalaCards organs/tissues related to Pharyngitis:

40
Testes, Tonsil, Heart, Lymph Node, Lung, Skin, Colon

Publications for Pharyngitis

Articles related to Pharyngitis:

(show top 50) (show all 5380)
# Title Authors PMID Year
1
The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. 46
21098571 2010
2
Potential mechanisms for failure to eradicate group A streptococci from the pharynx. 54 61
10506234 1999
3
Phenoxymethyl penicillin versus co-amoxiclav in the treatment of acute streptococcal pharyngitis, and the role of beta-lactamase activity in saliva. 61 54
8647754 1996
4
Treatment of beta-hemolytic streptococcal pharyngitis with cefaclor or penicillin. Efficacy and interaction with beta-lactamase-producing organisms in the pharynx. 61 54
1990041 1991
5
Lack of influence of beta-lactamase-producing flora on recovery of group A streptococci after treatment of acute pharyngitis. 54 61
2123240 1990
6
Anti-colitic effects of Physalin B on dextran sodium sulfate-induced BALB/c mice by suppressing multiple inflammatory signaling pathways. 61
32442587 2020
7
Lemierre's syndrome: A rare cause of septic emboli in a young adult. 61
32382372 2020
8
Clinical Features of Group A Streptococcus in Children With Pharyngitis: Carriers versus Acute Infection. 61
32040013 2020
9
Why and How Should We Treat Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome? 61
32342289 2020
10
Multicenter, open-label trial to assess the safety and tolerability of drospirenone 4.0 mg over 6 cycles in female adolescents, with a 7-cycle extension phase. 61
32088174 2020
11
Stigma Surrounding Sexually Transmitted Infections among Medical Students in Germany. 61
32500718 2020
12
Common genetic susceptibility loci link PFAPA syndrome, Behçet's disease, and recurrent aphthous stomatitis. 61
32518111 2020
13
Distribution of Streptococcal Pharyngitis and Acute Rheumatic Fever, Auckland, New Zealand, 2010-2016. 61
32441618 2020
14
Is acute rheumatic fever causally associated with a 6-day antibiotics therapy for pharyngitis? 61
32303355 2020
15
School-Based Streptococcal A Sore-Throat Treatment Programs and Acute Rheumatic Fever Amongst Indigenous Māori: A Retrospective Cohort Study. 61
32502125 2020
16
A highly-sensitive rapid test for the diagnosis of streptococcal pharyngitis: BD veritor ™ system. 61
32197187 2020
17
Efficacy and safety of rapid tests to guide antibiotic prescriptions for sore throat. 61
32497279 2020
18
Variations in antibiotic prescribing among village doctors in a rural region of Shandong province, China: a cross-sectional analysis of prescriptions. 61
32487580 2020
19
Total versus subtotal tonsillectomy for recurrent tonsillitis - a prospective randomized noninferiority clinical trial. 61
32049573 2020
20
Urine antigen-negative disseminated histoplasmosis mimicking post-transplant lymphoproliferative disorder. 61
32532906 2020
21
Toxic shock-like syndrome and COVID-19: A case report of multisystem inflammatory syndrome in children (MIS-C). 61
32532619 2020
22
Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy. 61
32512833 2020
23
Symptoms of COVID-19 among older adults: systematic review of biomedical literature. 61
32554345 2020
24
COVID-19 in Children, Pregnancy and Neonates: A Review of Epidemiologic and Clinical Features. 61
32398569 2020
25
Attenuated interferon and pro-inflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation. 61
32563187 2020
26
Pediatric COVID-19: Systematic review of the literature. 61
32531620 2020
27
Coagulase-negative staphylococci (CoNS) as a significant etiological factor of laryngological infections: a review. 61
32498711 2020
28
Pediatrician's approach to diagnosis and management of group A streptococcal pharyngitis. 61
31984431 2020
29
Streptococcus pyogenes genes that promote pharyngitis in primates. 61
32493846 2020
30
Emergency Department Prescribing Patterns for Pharyngitis in Children. 61
32501119 2020
31
A 45-year-old Female with an Atypical Presentation of Pharyngitis. 61
32426682 2020
32
Long-term impact of an intervention on rapid antigen detection tests in acute pharyngitis. 61
32482364 2020
33
Identifying Patients at Lowest Risk for Streptococcal Pharyngitis: A National Validation Study. 61
32067779 2020
34
Detection of Group A Streptococcus in the Saliva of Children Presenting With Pharyngitis Using the cobas Liat PCR System. 61
32425058 2020
35
Group A Streptococcus Testing in Pediatrics: the Move to Point-of-Care Molecular Testing. 61
32161094 2020
36
Outcome of upper respiratory tract infections in healthy children: Antibiotic stewardship in treatment of acute upper respiratory tract infections. 61
32494248 2020
37
Nanoparticle-assisted pyrrolidonyl arylamidase assay for a culture-free Group A Streptococcus pyogenes detection with image analysis. 61
32113544 2020
38
Evaluating the impact of influenza and streptococcus point-of-care testing and collaborative practice prescribing in a community pharmacy setting. 61
32253085 2020
39
Top 20 Research Studies of 2019 for Primary Care Physicians. 61
32412223 2020
40
Top 20 Research Studies of 2019 for Primary Care Physicians. 61
32352267 2020
41
Association of Pediatric Acute-Onset Neuropsychiatric Syndrome With Microstructural Differences in Brain Regions Detected via Diffusion-Weighted Magnetic Resonance Imaging. 61
32364596 2020
42
Incidence of pharyngitis, sinusitis, acute otitis media, and outpatient antibiotic prescribing preventable by vaccination against group A Streptococcus in the United States. 61
32374829 2020
43
Intramuscular Corticosteroids for Acute Upper Respiratory Infections Affects Healthcare Utilization. 61
32456500 2020
44
Approaching Otolaryngology Patients During the COVID-19 Pandemic. 61
32396445 2020
45
The Australian burden of invasive group A streptococcal disease - a narrative review. 61
32372512 2020
46
Prevalence of group A Streptococcal infection in Africa to inform GAS vaccines for rheumatic heart disease: A systematic review and meta-analysis. 61
31864789 2020
47
An up-to-date review on bio-resource therapeutics effective against bacterial species frequently associated with chronic sinusitis and tonsillitis. 61
32368971 2020
48
Herpes simplex virus as a cause of pharyngitis. 61
32359469 2020
49
Combined in-person and tele-delivered mobile school clinic: A novel approach for improving access to healthcare during school hours. 61
32393140 2020
50
Early impact of the implementation of Medicaid episode-based payment reforms in Arkansas. 61
32438480 2020

Variations for Pharyngitis

Expression for Pharyngitis

Search GEO for disease gene expression data for Pharyngitis.

Pathways for Pharyngitis

Pathways related to Pharyngitis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 PTGS2 NLRP3 MEFV IL1B HLA-DRB1 FCGR1A
2
Show member pathways
13.28 PTGS2 IL1B HLA-DRB1 FCGR1A CXCL8 CSF2
3
Show member pathways
12.76 IL1B HLA-DRB1 CXCL8 CD40LG CD4
4 12.3 NLRP3 IL1B CXCL8 CSF2
5
Show member pathways
12.24 PTGS2 IL1B CXCL8 CSF2
6 12.18 FCGR1A ETV5 CXCL8 CSF2
7
Show member pathways
12.08 PTGS2 IL1B HLA-DRB1 FCGR1A CD40LG
8 12.02 NLRP3 MEFV IL1B CXCL8 CARD8
9 11.94 NLRP3 MEFV IL1B CXCL8
10
Show member pathways
11.9 IL1B HLA-DRB1 ETV5 CD4
11 11.84 PTGS2 IL1B CXCL8 CD40LG
12 11.82 IL1B CXCL8 CSF2 CD1A
13 11.76 IL1B HLA-DRB1 CXCL8 CSF2
14 11.67 NLRP3 IL1B CXCL8
15
Show member pathways
11.64 PTGS2 CXCL8 CSF2 CD40LG
16 11.6 IL1B CSF2 CD4 CD1A
17 11.57 IL1B CXCL8 CSF2
18 11.46 IL1B CXCL8 CD40LG
19 11.31 PTGS2 IL1B CXCL8 CSF2
20 11.17 NLRP3 MEFV IL1B CARD8
21 11.16 HLA-DRB1 ETV5 CD4
22
Show member pathways
11.15 PTGS2 IL1B CXCL8 CSF2 CD40LG
23 11.1 IL1B HLA-DRB1 FCGR1A CSF2 CD4 CD1A
24 10.93 PTGS2 CXCL8 CRP
25 10.92 IL1B HLA-DRB1 CSF2 CD4

GO Terms for Pharyngitis

Cellular components related to Pharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NLRP3 inflammasome complex GO:0072559 8.96 NLRP3 CARD8
2 inflammasome complex GO:0061702 8.62 NLRP3 CARD8

Biological processes related to Pharyngitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.95 NLRP3 MEFV HLA-DRB1 FCGR1A CD4 CD1A
2 cellular response to lipopolysaccharide GO:0071222 9.71 NLRP3 IL1B CXCL8 CSF2
3 cytokine-mediated signaling pathway GO:0019221 9.65 PTGS2 IL1B CXCL8 CSF2 CD4
4 positive regulation of T cell proliferation GO:0042102 9.63 IL1B CD40LG CD4
5 positive regulation of monocyte differentiation GO:0045657 9.54 HLA-DRB1 CD4
6 negative regulation of blood vessel diameter GO:0097756 9.52 PTGS2 CRP
7 positive regulation of viral entry into host cell GO:0046598 9.51 HLA-DRB1 CD4
8 inflammatory response GO:0006954 9.5 PTGS2 NLRP3 MEFV IL1B CXCL8 CRP
9 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.49 CSF2 CD4
10 interleukin-1 beta production GO:0032611 9.43 NLRP3 IL1B
11 positive regulation of prostaglandin biosynthetic process GO:0031394 9.37 PTGS2 IL1B
12 macrophage differentiation GO:0030225 9.33 HLA-DRB1 CSF2 CD4
13 positive regulation of fever generation GO:0031622 9.32 PTGS2 IL1B
14 immune response GO:0006955 9.23 IL1B HLA-DRB1 FCGR1A CXCL8 CSF2 CD40LG

Molecular functions related to Pharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 NLRP3 MVK MEFV LACTB CRP CD4
2 cytokine activity GO:0005125 8.92 IL1B CXCL8 CSF2 CD40LG

Sources for Pharyngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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