MCID: PHR002
MIFTS: 32

Pharyngoconjunctival Fever

Categories: Infectious diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Pharyngoconjunctival Fever

MalaCards integrated aliases for Pharyngoconjunctival Fever:

Name: Pharyngoconjunctival Fever 12 15 17
Pharyngo-Conjunctival Fever 12 70
Adenoviral Pharyngoconjunctivitis 12
Adenovirus Infections, Human 44

Classifications:



External Ids:

Disease Ontology 12 DOID:13801
ICD9CM 34 077.2
MeSH 44 D000258
NCIt 50 C34924
SNOMED-CT 67 70385007
UMLS 70 C0031351

Summaries for Pharyngoconjunctival Fever

Disease Ontology : 12 A viral infectious disease that results in infection located in pharynx or located in conjunctiva, has material basis in Human adenovirus 3 or has material basis in Human adenovirus 7, which are transmitted by droplet spread of respiratory secretions or transmitted by fomites. The infection has symptom fever, has symptom lymphadenopathy of the neck, and has symptom headache.

MalaCards based summary : Pharyngoconjunctival Fever, also known as pharyngo-conjunctival fever, is related to conjunctival folliculosis and shipyard eye. An important gene associated with Pharyngoconjunctival Fever is CXADR (CXADR Ig-Like Cell Adhesion Molecule), and among its related pathways/superpathways are Cytoskeletal Signaling and Measles. Affiliated tissues include eye, colon and placenta, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Wikipedia : 73 Adenovirus infections most commonly cause illness of the respiratory system; however, depending on the... more...

Related Diseases for Pharyngoconjunctival Fever

Diseases related to Pharyngoconjunctival Fever via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 conjunctival folliculosis 29.8 PSEN2 CD46
2 shipyard eye 29.7 PSEN2 CXADR CD46
3 conjunctivitis 10.4
4 pharyngitis 10.4
5 otitis media 10.0
6 kawasaki disease 10.0
7 keratoconjunctivitis 10.0
8 post-transplant lymphoproliferative disease 9.8 TNFSF10 TNFRSF10A
9 viral infectious disease 9.5 TNFSF10 CXADR CD46

Graphical network of the top 20 diseases related to Pharyngoconjunctival Fever:



Diseases related to Pharyngoconjunctival Fever

Symptoms & Phenotypes for Pharyngoconjunctival Fever

MGI Mouse Phenotypes related to Pharyngoconjunctival Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 CD46 CXADR E2F1 ITGAV ONECUT1 PSEN2
2 endocrine/exocrine gland MP:0005379 9.8 CXADR E2F1 ITGAV ONECUT1 PSEN2 TNFRSF10A
3 digestive/alimentary MP:0005381 9.72 CXADR E2F1 ITGAV ONECUT1 PSEN2
4 immune system MP:0005387 9.7 CXADR E2F1 ITGAV ONECUT1 PSEN2 TNFRSF10A
5 mortality/aging MP:0010768 9.56 CXADR E2F1 FBL ITGAV ONECUT1 PSEN2
6 neoplasm MP:0002006 8.92 E2F1 ITGAV TNFRSF10A TNFSF10

Drugs & Therapeutics for Pharyngoconjunctival Fever

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Double Blind Placebo-controled Randomized Comparative Multicentered Study of Efficacy and Safety of Filtrum-STI, 0,4g Tablets (Produced by AVVA RUS) in Children With Viral Gastroenteritis Unknown status NCT01113346 Phase 2, Phase 3 Filtrum-STI (lignin hydrolytic);Placebo
2 Incidence and Outcomes Associated With the Management of Adenovirus Infections in Allogeneic Hematopoietic Cell Transplant Recipients: AdVance Completed NCT04285788

Search NIH Clinical Center for Pharyngoconjunctival Fever

Cochrane evidence based reviews: adenovirus infections, human

Genetic Tests for Pharyngoconjunctival Fever

Anatomical Context for Pharyngoconjunctival Fever

MalaCards organs/tissues related to Pharyngoconjunctival Fever:

40
Eye, Colon, Placenta, Monocytes

Publications for Pharyngoconjunctival Fever

Articles related to Pharyngoconjunctival Fever:

(show top 50) (show all 135)
# Title Authors PMID Year
1
Evaluation of the Anti-Adenoviral Activity of ALTANT, an Ozonated Alcohol Disinfectant. 61
32350225 2020
2
Comparative study of clinical and epidemiological characteristics of major pediatric adenovirus epidemics in southern Taiwan. 61
31370781 2019
3
[Detection and Molecular Characterization of Human Adenoviruses from Acute Conjunctivitis Cases]. 61
31414631 2019
4
Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children. 61
30815882 2019
5
Sialic Acid-Containing Glycans as Cellular Receptors for Ocular Human Adenoviruses: Implications for Tropism and Treatment. 61
31035532 2019
6
A swimming pool-associated outbreak of pharyngoconjunctival fever caused by human adenovirus type 4 in Beijing, China. 61
30144556 2018
7
Adenovirus Ocular Infections: Prevalence, Pathology, Pitfalls, and Practical Pointers. 61
29664772 2018
8
Pharyngoconjunctival fever. 61
29771905 2018
9
Pathogenesis and management of adenoviral keratoconjunctivitis. 61
30046247 2018
10
C-reactive protein and N-terminal pro-brain natriuretic peptide discrepancy: a differentiation of adenoviral pharyngoconjunctival fever from Kawasaki disease. 61
29441107 2018
11
Virology and epidemiology analyses of global adenovirus-associated conjunctivitis outbreaks, 1953-2013. 61
26732024 2016
12
Proposition of real-time precise prediction model of infectious disease patients from Prescription Surveillance using the National Database of Electronic Medical Claims. 61
26320387 2015
13
Adenoviral keratoconjunctivitis. 61
26077630 2015
14
Evaluation of new immunochromatographic assay kit for adenovirus detection in throat swab: comparison with culture and real-time PCR results. 61
24594452 2014
15
Human adenovirus: Viral pathogen with increasing importance. 61
24678403 2014
16
Adenoviral keratoconjunctivitis: an update. 61
23473088 2013
17
Two adenovirus serotype 3 outbreaks associated with febrile respiratory disease and pharyngoconjunctival fever in children under 15 years of age in Hangzhou, China, during 2011. 61
22442311 2012
18
Isolation of an intertypic recombinant human adenovirus (candidate type 56) from the pharyngeal swab of a patient with pharyngoconjunctival fever. 61
22996227 2012
19
Age-specific sex-related differences in infections: a statistical analysis of national surveillance data in Japan. 61
22848753 2012
20
[Adenoviral keratoconjunctivitis]. 61
20724026 2010
21
Secular trend of genome types of respiratory adenovirus type 3 during 1983-2005: a study from Taiwan. 61
20033743 2010
22
Antitumor effects of telomelysin in combination with paclitaxel or cisplatin on head and neck squamous cell carcinoma. 54
20043095 2010
23
Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells. 54
19549835 2009
24
A swimming pool-related outbreak of pharyngoconjunctival fever in children due to adenovirus type 4, Gipuzkoa, Spain, 2008. 61
19250625 2009
25
Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004-2005. 61
17876605 2008
26
Epidemics of influenza and pediatric diseases observed in infectious disease surveillance in Japan, 1999-2005. 61
18239337 2007
27
Functional effects of coxsackievirus and adenovirus receptor glycosylation on homophilic adhesion and adenoviral infection. 54
17376928 2007
28
[Pharyngoconjunctival fever (PCF)--adenovirus infection]. 61
17494157 2007
29
The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems. 54
17308048 2007
30
Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin. 54
17283156 2007
31
Evaluation of sampling technique and transport media for the diagnostics of adenoviral eye infections. Adenovirus sampling and transport. 61
16550405 2006
32
Adenovirus-induced alterations in host cell gene expression prior to the onset of viral gene expression. 54
16860366 2006
33
Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition. 54
16452224 2006
34
Coxsackie and adenovirus receptor binding ablation reduces adenovirus liver tropism and toxicity. 54
15761264 2005
35
Adenoviruses for treatment of cancer. 54
15902845 2005
36
Evaluation of a bedside immunochromatographic test for detection of adenovirus in respiratory samples, by comparison to virus isolation, PCR, and real-time PCR. 61
15583271 2004
37
Respiratory adenoviral infections in children: a study of hospitalized cases in southern Taiwan in 2001--2002. 61
15510759 2004
38
High-level expression of the coxsackievirus and adenovirus receptor messenger RNA in osteosarcoma, Ewing's sarcoma, and benign neurogenic tumors among musculoskeletal tumors. 54
15173092 2004
39
Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo. 54
14525937 2003
40
The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells. 54
14614025 2003
41
MDM2 promotes ubiquitination and degradation of MDMX. 54
12860999 2003
42
Activation of adenovirus early promoters and lytic phase in differentiated strata of organotypic cultures of human keratinocytes. 54
12743310 2003
43
Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor. 54
12576544 2003
44
Mechanism of restriction of normal and cystic fibrosis transmembrane conductance regulator-deficient human tracheal gland cells to adenovirus infection and ad-mediated gene transfer. 54
12397023 2002
45
Reduced expression of coxsackievirus and adenovirus receptor (CAR) in tumor tissue compared to normal epithelium in head and neck squamous cell carcinoma patients. 54
12529974 2002
46
Fatty acid modification of the coxsackievirus and adenovirus receptor. 54
12021372 2002
47
AMP-activated kinase regulates cytoplasmic HuR. 54
11971974 2002
48
C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells. 54
11961668 2002
49
Enhancement of the adenoviral sensitivity of human ovarian cancer cells by transient expression of coxsackievirus and adenovirus receptor (CAR). 54
11972385 2002
50
Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen. 54
11915024 2002

Variations for Pharyngoconjunctival Fever

Expression for Pharyngoconjunctival Fever

Search GEO for disease gene expression data for Pharyngoconjunctival Fever.

Pathways for Pharyngoconjunctival Fever

Pathways related to Pharyngoconjunctival Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.99 ITGAV FBL CXADR
2
Show member pathways
11.63 TNFSF10 TNFRSF10A E2F1 CD46
3
Show member pathways
11.6 TNFSF10 TNFRSF10A E2F1
4
Show member pathways
11.38 TNFRSF10A ITGAV CXADR
5 10.93 TNFSF10 TNFRSF10A

GO Terms for Pharyngoconjunctival Fever

Cellular components related to Pharyngoconjunctival Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 TNFSF10 PSEN2 ITGAV CXADR CD46
2 membrane raft GO:0045121 9.33 TNFRSF10A PSEN2 CXADR
3 cell surface GO:0009986 8.92 TNFRSF10A PSEN2 ITGAV CD46

Biological processes related to Pharyngoconjunctival Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.56 ITGAV E2F1 CXADR CD46
2 leukocyte migration GO:0050900 9.5 TNFRSF10A ITGAV CXADR
3 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.37 TNFSF10 TNFRSF10A
4 positive regulation of apoptotic process GO:0043065 9.26 TNFSF10 TNFRSF10A PSEN2 E2F1
5 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.16 TNFSF10 TNFRSF10A
6 viral entry into host cell GO:0046718 8.8 ITGAV CXADR CD46

Molecular functions related to Pharyngoconjunctival Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.33 TNFSF10 ITGAV CXADR
2 virus receptor activity GO:0001618 9.13 ITGAV CXADR CD46
3 TRAIL binding GO:0045569 8.62 TNFSF10 TNFRSF10A

Sources for Pharyngoconjunctival Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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