MCID: PHR002
MIFTS: 35

Pharyngoconjunctival Fever

Categories: Infectious diseases

Aliases & Classifications for Pharyngoconjunctival Fever

MalaCards integrated aliases for Pharyngoconjunctival Fever:

Name: Pharyngoconjunctival Fever 12 15
Pharyngo-Conjunctival Fever 12 73
Adenoviral Pharyngoconjunctivitis 12
Adenovirus Infections, Human 44

Classifications:



External Ids:

Disease Ontology 12 DOID:13801
ICD9CM 35 077.2
MeSH 44 D000258
NCIt 50 C34924
SNOMED-CT 68 70385007
UMLS 73 C0031351

Summaries for Pharyngoconjunctival Fever

Disease Ontology : 12 A viral infectious disease that results in infection located in pharynx or located in conjunctiva, has material basis in Human adenovirus 3 or has material basis in Human adenovirus 7, which are transmitted by droplet spread of respiratory secretions or transmitted by fomites. The infection has symptom fever, has symptom lymphadenopathy of the neck, and has symptom headache.

MalaCards based summary : Pharyngoconjunctival Fever, also known as pharyngo-conjunctival fever, is related to pharyngitis and conjunctivitis, and has symptoms including fever, lymphadenopathy of the neck and headache. An important gene associated with Pharyngoconjunctival Fever is BAD (BCL2 Associated Agonist Of Cell Death), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Affiliated tissues include pharynx or, eye and testes, and related phenotypes are Increased cell death HMECs cells and cellular

CDC : 3 Adenoviruses are common viruses that cause a range of illness. They can cause cold-like symptoms, sore throat, bronchitis, pneumonia, diarrhea, and pink eye (conjunctivitis). You can get an adenovirus infection at any age. People with weakened immune systems or existing respiratory or cardiac disease are more likely than others to get very sick from an adenovirus infection…

Wikipedia : 76 Adenovirus infections most commonly cause illness of the respiratory system; however, depending on the... more...

Related Diseases for Pharyngoconjunctival Fever

Diseases related to Pharyngoconjunctival Fever via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pharyngitis 10.2
2 conjunctivitis 10.1
3 adenoiditis 9.9
4 aging 9.9
5 kawasaki disease 9.9

Graphical network of the top 20 diseases related to Pharyngoconjunctival Fever:



Diseases related to Pharyngoconjunctival Fever

Symptoms & Phenotypes for Pharyngoconjunctival Fever

Symptoms:

12
  • fever
  • lymphadenopathy of the neck
  • headache

GenomeRNAi Phenotypes related to Pharyngoconjunctival Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 8.8 ITGAV PSEN2 TNFRSF10A

MGI Mouse Phenotypes related to Pharyngoconjunctival Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 BAD E2F1 ITGAV PSEN2 TNFRSF10A
2 endocrine/exocrine gland MP:0005379 9.77 BAD E2F1 ITGAV PSEN2 TNFRSF10A
3 hematopoietic system MP:0005397 9.72 E2F1 ITGAV PSEN2 TNFRSF10A BAD
4 homeostasis/metabolism MP:0005376 9.65 BAD E2F1 ITGAV PSEN2 TNFRSF10A
5 immune system MP:0005387 9.55 BAD E2F1 ITGAV PSEN2 TNFRSF10A
6 mortality/aging MP:0010768 9.35 BAD E2F1 ITGAV PSEN2 TNFRSF10A
7 neoplasm MP:0002006 8.92 BAD E2F1 ITGAV TNFRSF10A

Drugs & Therapeutics for Pharyngoconjunctival Fever

Search Clinical Trials , NIH Clinical Center for Pharyngoconjunctival Fever

Cochrane evidence based reviews: adenovirus infections, human

Genetic Tests for Pharyngoconjunctival Fever

Anatomical Context for Pharyngoconjunctival Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Pharyngoconjunctival Fever:

19
Pharynx Or

MalaCards organs/tissues related to Pharyngoconjunctival Fever:

41
Eye, Testes, Brain

Publications for Pharyngoconjunctival Fever

Articles related to Pharyngoconjunctival Fever:

(show all 31)
# Title Authors Year
1
C-reactive protein and N-terminal pro-brain natriuretic peptide discrepancy: a differentiation of adenoviral pharyngoconjunctival fever from Kawasaki disease. ( 29441107 )
2018
2
Pharyngoconjunctival fever. ( 29771905 )
2018
3
Two adenovirus serotype 3 outbreaks associated with febrile respiratory disease and pharyngoconjunctival fever in children under 15 years of age in Hangzhou, China, during 2011. ( 22442311 )
2012
4
Isolation of an intertypic recombinant human adenovirus (candidate type 56) from the pharyngeal swab of a patient with pharyngoconjunctival fever. ( 22996227 )
2012
5
A swimming pool-related outbreak of pharyngoconjunctival fever in children due to adenovirus type 4, Gipuzkoa, Spain, 2008. ( 19250625 )
2009
6
A primary school outbreak of pharyngoconjunctival fever caused by adenovirus type 3. ( 11280197 )
2001
7
Outbreak of pharyngoconjunctival fever at a summer camp--North Carolina, 1991. ( 1579128 )
1992
8
Outbreak of pharyngoconjunctival fever at a summer camp--North Carolina, 1991. ( 1517549 )
1992
9
Pharyngoconjunctival fever caused by adenovirus type 11. ( 1549418 )
1992
10
From the Centers for Disease Control. Outbreak of pharyngoconjunctival fever at a summer camp--North Carolina, 1991. ( 1583745 )
1992
11
Rapid diagnosis of adenovirus pharyngoconjunctival fever: use of a monoclonal antibody-based ELISA test during an outbreak. ( 2547824 )
1989
12
Genome analysis of adenovirus 4a, a causative agent of pharyngoconjunctival fever and respiratory diseases in Brazil. ( 2850347 )
1988
13
Genome analysis of species 3 adenoviruses isolated during summer outbreaks of conjunctivitis and pharyngoconjunctival fever in the Glasgow and London areas in 1981. ( 3009697 )
1986
14
Pharyngoconjunctival fever. ( 6098226 )
1984
15
Pharyngoconjunctival fever caused by adenovirus type 4: report of a swimming pool-related outbreak with recovery of virus from pool water. ( 222852 )
1979
16
Pharyngoconjunctival fever caused by adenovirus type 19. ( 213752 )
1978
17
Successive overlapping outbreaks of febrile pharyngitis and pharyngoconjunctival fever associated with adenovirus types 2 and 7, in a Kibbutz. ( 4374455 )
1974
18
Effectiveness of N1, N1-anhydrobis (beta-hydroxyethyl) biguanide hydrochloride (ABOB) in the treatment of pharyngoconjunctival fever. ( 4299710 )
1968
19
An outbreak of pharyngoconjunctival fever due to adenovirus type 3. ( 4290963 )
1966
20
Pharyngoconjunctival fever due to type 1 adenovirus; report of three cases. ( 13493754 )
1958
21
An outbreak of pharyngoconjunctival fever caused by types 3 and 4 adenovirus at Waalwijk, The Netherlands. ( 13571224 )
1958
22
Clinical manifestations of pharyngoconjunctival fever. ( 13411119 )
1957
23
Sporadic cases of pharyngoconjunctival fever in Northern California, 1955-1956. ( 13411120 )
1957
24
An intrafamilial epidemic of pharyngoconjunctival fever. ( 13393836 )
1957
25
Studies on the adenovirus as an etiological agent of pharyngoconjunctival fever. ( 13474843 )
1957
26
Epidemiology of pharyngoconjunctival fever. ( 13411125 )
1957
27
Adenoviruses associated with pharyngoconjunctival fever; isolation of adenovirus type 7 & serological studies suggesting its etiological role in an epidemic in Helsinki. ( 13470509 )
1957
28
Pharyngoconjunctival fever; report of an epidemic outbreak. ( 13372054 )
1956
29
Conjunctivitis in adenoidal-pharyngeal-conjunctival virus infection; pharyngoconjunctival fever, a newly described entity. ( 14397906 )
1955
30
Production of pharyngoconjunctival fever in human volunteers inoculated with APC viruses. ( 13274067 )
1955
31
Pharyngoconjunctival fever; epidemiological studies of a recently recognized disease entity. ( 14353643 )
1955

Variations for Pharyngoconjunctival Fever

Expression for Pharyngoconjunctival Fever

Search GEO for disease gene expression data for Pharyngoconjunctival Fever.

Pathways for Pharyngoconjunctival Fever

Pathways related to Pharyngoconjunctival Fever according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 BAD E2F1 ITGAV PSEN2 TNFRSF10A
2
Show member pathways
12.82 BAD E2F1 ITGAV PSEN2 TNFRSF10A
3
Show member pathways
12.44 BAD E2F1 ITGAV
4 12.27 BAD E2F1 ITGAV
5
Show member pathways
12.13 BAD E2F1 PSEN2
6 11.7 BAD E2F1
7
Show member pathways
11.57 BAD E2F1
8 11.52 BAD ITGAV
9 11.37 E2F1 ITGAV
10
Show member pathways
11.14 BAD E2F1
11 10.95 BAD E2F1 ITGAV
12 10.82 BAD E2F1

GO Terms for Pharyngoconjunctival Fever

Cellular components related to Pharyngoconjunctival Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 ITGAV PSEN2 TNFRSF10A

Biological processes related to Pharyngoconjunctival Fever according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.65 BAD E2F1 TNFRSF10A
2 positive regulation of MAPK cascade GO:0043410 9.51 ITGAV TNFRSF10A
3 cellular response to hypoxia GO:0071456 9.49 BAD E2F1
4 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.46 BAD TNFRSF10A
5 apoptotic signaling pathway GO:0097190 9.43 BAD TNFRSF10A
6 positive regulation of apoptotic process GO:0043065 9.43 BAD E2F1 PSEN2
7 cellular response to mechanical stimulus GO:0071260 9.4 BAD TNFRSF10A
8 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.37 BAD E2F1
9 extrinsic apoptotic signaling pathway GO:0097191 9.32 BAD TNFRSF10A
10 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.16 BAD TNFRSF10A
11 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 8.96 BAD ITGAV
12 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 8.62 BAD E2F1

Molecular functions related to Pharyngoconjunctival Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 ITGAV TNFRSF10A

Sources for Pharyngoconjunctival Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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