MCID: PHR008
MIFTS: 29

Pharynx Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pharynx Squamous Cell Carcinoma

MalaCards integrated aliases for Pharynx Squamous Cell Carcinoma:

Name: Pharynx Squamous Cell Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050921

Summaries for Pharynx Squamous Cell Carcinoma

Disease Ontology : 12 A pharynx cancer that has material basis in squamous cells.

MalaCards based summary : Pharynx Squamous Cell Carcinoma is related to squamous cell carcinoma and macroglossia. An important gene associated with Pharynx Squamous Cell Carcinoma is COL11A1 (Collagen Type XI Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. Affiliated tissues include brain, colon and tongue, and related phenotypes are respiratory system and skeleton

Related Diseases for Pharynx Squamous Cell Carcinoma

Diseases related to Pharynx Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.2
2 macroglossia 10.0 COL11A1 PTEN
3 patulous eustachian tube 10.0
4 proteus syndrome 10.0 AKT1 PTEN
5 cowden syndrome 1 10.0 AKT1 PTEN
6 central nervous system cancer 10.0 AKT1 PTEN
7 endometrial adenocarcinoma 10.0 AKT1 PTEN
8 prostate disease 10.0 AKT1 PTEN
9 suppression of tumorigenicity 12 10.0 AKT1 PTEN
10 meningioma, familial 9.9 AKT1 PTEN
11 breast adenocarcinoma 9.9 AKT1 PTEN
12 aging 9.9 AKT1 PTEN
13 nasopharyngeal disease 9.9 AKT1 CASP3
14 pharynx cancer 9.9 AKT1 CASP3
15 cervix disease 9.9 AKT1 CASP3
16 autonomic nervous system neoplasm 9.9 AKT1 CASP3
17 small cell cancer of the lung 9.9 AKT1 PTEN
18 peripheral nervous system neoplasm 9.9 AKT1 CASP3
19 toxic encephalopathy 9.9 AKT1 CASP3
20 leukocyte disease 9.9 AKT1 CASP3
21 colonic disease 9.9 AKT1 CASP3
22 stomach disease 9.9 AKT1 CASP3
23 primary effusion lymphoma 9.9 CASP3 PTEN
24 intestinal disease 9.9 AKT1 CASP3
25 tongue squamous cell carcinoma 9.9 AKT1 CASP3
26 respiratory system disease 9.8 AKT1 CASP3
27 gastrointestinal system disease 9.8 AKT1 CASP3
28 osteogenic sarcoma 9.8 AKT1 CASP3
29 pancreas adenocarcinoma 9.8 AKT1 CASP3
30 mantle cell lymphoma 9.7 AKT1 CASP3
31 nervous system disease 9.7 AKT1 CASP3
32 gastrointestinal stromal tumor 9.6 AKT1 PTEN
33 supratentorial cancer 9.6 AKT1 CASP3 PTEN
34 cerebrum cancer 9.6 AKT1 CASP3 PTEN
35 uterine anomalies 9.6 AKT1 CASP3 PTEN
36 male reproductive organ cancer 9.6 AKT1 CASP3 PTEN
37 male reproductive system disease 9.6 AKT1 CASP3 PTEN
38 reproductive system disease 9.6 AKT1 CASP3 PTEN
39 female reproductive system disease 9.6 AKT1 CASP3 PTEN
40 nervous system cancer 9.6 AKT1 CASP3 PTEN
41 respiratory system cancer 9.6 AKT1 CASP3 PTEN
42 gastrointestinal system cancer 9.6 AKT1 CASP3 PTEN
43 endocrine gland cancer 9.6 AKT1 CASP3 PTEN
44 ovarian disease 9.6 AKT1 CASP3 PTEN
45 squamous cell carcinoma, head and neck 9.6 AKT1 CASP3 PTEN
46 large intestine cancer 9.6 AKT1 CASP3 PTEN
47 brain cancer 9.6 AKT1 CASP3 PTEN
48 gastric adenocarcinoma 9.6 AKT1 CASP3 PTEN
49 medulloblastoma 9.5 AKT1 CASP3 PTEN
50 cervical cancer 9.5 AKT1 CASP3 PTEN

Graphical network of the top 20 diseases related to Pharynx Squamous Cell Carcinoma:



Diseases related to Pharynx Squamous Cell Carcinoma

Symptoms & Phenotypes for Pharynx Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Pharynx Squamous Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.26 AKT1 CASP3 COL11A1 PTEN
2 skeleton MP:0005390 8.92 AKT1 CASP3 COL11A1 PTEN

Drugs & Therapeutics for Pharynx Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Pharynx Squamous Cell Carcinoma

Genetic Tests for Pharynx Squamous Cell Carcinoma

Anatomical Context for Pharynx Squamous Cell Carcinoma

MalaCards organs/tissues related to Pharynx Squamous Cell Carcinoma:

42
Brain, Colon, Tongue, Cervix, Pancreas, Prostate, Thyroid

Publications for Pharynx Squamous Cell Carcinoma

Articles related to Pharynx Squamous Cell Carcinoma:

# Title Authors Year
1
Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients. ( 30245069 )
2018
2
Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma. ( 15023835 )
2004

Variations for Pharynx Squamous Cell Carcinoma

Cosmic variations for Pharynx Squamous Cell Carcinoma:

9 (show top 50) (show all 553)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6970691 ZFHX3 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.3676C>T p.P1226S 16:72811765-72811765 0
2 COSM6961423 ZFHX3 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.10897C>T p.P3633S 16:72787379-72787379 0
3 COSM6958980 TSC2 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.3802C>G p.R1268G 16:2081786-2081786 0
4 COSM3277548 TSC2 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.3734G>A p.R1245Q 16:2081718-2081718 0
5 COSM6911446 TP63 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.1056G>T p.R352S 3:189868643-189868643 0
6 COSM6910538 TP63 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.1567C>T p.Q523* 3:189889399-189889399 0
7 COSM6549 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.743G>T p.R248L 17:7674220-7674220 0
8 COSM6932 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 0
9 COSM44151 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.535C>A p.H179N 17:7675077-7675077 0
10 COSM44988 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.374C>T p.T125M 17:7675995-7675995 0
11 COSM10662 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
12 COSM45653 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.281C>G p.S94* 17:7676088-7676088 0
13 COSM10725 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.701A>G p.Y234C 17:7674262-7674262 0
14 COSM11780 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.338T>C p.F113S 17:7676031-7676031 0
15 COSM43650 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.638G>T p.R213L 17:7674893-7674893 0
16 COSM43947 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 0
17 COSM44070 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.1031T>C p.L344P 17:7670678-7670678 0
18 COSM10758 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 0
19 COSM11333 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.499C>T p.Q167* 17:7675113-7675113 0
20 COSM10660 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 0
21 COSM10905 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 0
22 COSM10701 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.824G>T p.C275F 17:7673796-7673796 0
23 COSM44329 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.470T>A p.V157D 17:7675142-7675142 0
24 COSM10659 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 0
25 COSM43714 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.836G>A p.G279E 17:7673784-7673784 0
26 COSM10867 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 0
27 COSM10889 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.536A>G p.H179R 17:7675076-7675076 0
28 COSM11286 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.1015G>T p.E339* 17:7670694-7670694 0
29 COSM10834 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.711G>A p.M237I 17:7674252-7674252 0
30 COSM10667 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.646G>A p.V216M 17:7674885-7674885 0
31 COSM10812 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.722C>T p.S241F 17:7674241-7674241 0
32 COSM10648 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 0
33 COSM10656 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 0
34 COSM10768 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 0
35 COSM11244 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.764T>A p.I255N 17:7674199-7674199 0
36 COSM45367 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.672+1G>C p.? 17:7674858-7674858 0
37 COSM10704 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 0
38 COSM44346 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.875A>C p.K292T 17:7673745-7673745 0
39 COSM10813 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.394A>G p.K132E 17:7675218-7675218 0
40 COSM44472 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.922C>A p.L308M 17:7673606-7673606 0
41 COSM43778 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.713G>T p.C238F 17:7674250-7674250 0
42 COSM11524 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.730G>T p.G244C 17:7674233-7674233 0
43 COSM44093 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.644G>A p.S215N 17:7674887-7674887 0
44 COSM45589 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.1037A>C p.E346A 17:7670672-7670672 0
45 COSM45243 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.374C>G p.T125R 17:7675995-7675995 0
46 COSM69404 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.994-1G>A p.? 17:7670716-7670716 0
47 COSM10943 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.841G>C p.D281H 17:7673779-7673779 0
48 COSM43606 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.734G>A p.G245D 17:7674229-7674229 0
49 COSM44142 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.377A>C p.Y126S 17:7675235-7675235 0
50 COSM97868 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.919+1G>A p.? 17:7673700-7673700 0

Expression for Pharynx Squamous Cell Carcinoma

Search GEO for disease gene expression data for Pharynx Squamous Cell Carcinoma.

Pathways for Pharynx Squamous Cell Carcinoma

Pathways related to Pharynx Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 AKT1 CASP3 COL11A1 PTEN
2
Show member pathways
12.93 AKT1 CASP3 COL11A1 PTEN
3
Show member pathways
12.75 AKT1 COL11A1 PTEN
4
Show member pathways
12.67 AKT1 CASP3 PTEN
5
Show member pathways
12.65 AKT1 CASP3 PTEN
6
Show member pathways
12.65 AKT1 CASP3 PTEN
7
Show member pathways
12.58 AKT1 COL11A1 PTEN
8
Show member pathways
12.55 AKT1 CASP3 PTEN
9 12.5 AKT1 CASP3 PTEN
10
Show member pathways
12.37 AKT1 CASP3 PTEN
11
Show member pathways
12.32 AKT1 CASP3 PTEN
12
Show member pathways
12.08 AKT1 CASP3 PTEN
13
Show member pathways
11.85 AKT1 PTEN
14 11.81 AKT1 PTEN
15
Show member pathways
11.8 AKT1 CASP3
16
Show member pathways
11.79 AKT1 CASP3
17 11.77 AKT1 PTEN
18
Show member pathways
11.77 AKT1 CASP3 PTEN
19 11.76 AKT1 PTEN
20
Show member pathways
11.76 AKT1 CASP3 PTEN
21 11.74 AKT1 PTEN
22 11.73 AKT1 CASP3
23
Show member pathways
11.72 AKT1 PTEN
24
Show member pathways
11.71 AKT1 PTEN
25 11.7 AKT1 CASP3 PTEN
26 11.67 AKT1 CASP3
27 11.64 AKT1 CASP3
28 11.63 AKT1 PTEN
29 11.62 AKT1 PTEN
30 11.62 AKT1 CASP3 PTEN
31 11.58 AKT1 PTEN
32
Show member pathways
11.57 AKT1 CASP3
33
Show member pathways
11.57 AKT1 CASP3
34 11.51 AKT1 CASP3
35 11.45 AKT1 CASP3
36
Show member pathways
11.44 AKT1 CASP3
37 11.44 AKT1 PTEN
38 11.42 AKT1 PTEN
39 11.42 AKT1 CASP3
40 11.35 AKT1 CASP3
41 11.32 AKT1 PTEN
42 11.3 AKT1 CASP3 PTEN
43 11.28 AKT1 CASP3
44 11.15 AKT1 CASP3
45 11.04 AKT1 CASP3
46 11.02 AKT1 PTEN
47 11 AKT1 PTEN
48 10.95 AKT1 PTEN
49 10.86 AKT1 CASP3 PTEN
50 10.79 AKT1 CASP3

GO Terms for Pharynx Squamous Cell Carcinoma

Biological processes related to Pharynx Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.72 AKT1 CASP3 PTEN
2 negative regulation of apoptotic process GO:0043066 9.7 AKT1 CASP3 PTEN
3 sensory perception of sound GO:0007605 9.6 CASP3 COL11A1
4 response to organic cyclic compound GO:0014070 9.59 CASP3 PTEN
5 cellular response to hypoxia GO:0071456 9.58 AKT1 PTEN
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.58 AKT1 PTEN
7 positive regulation of apoptotic process GO:0043065 9.58 AKT1 CASP3 PTEN
8 response to estradiol GO:0032355 9.57 CASP3 PTEN
9 cellular response to insulin stimulus GO:0032869 9.56 AKT1 PTEN
10 response to glucose GO:0009749 9.54 CASP3 PTEN
11 cellular response to organic cyclic compound GO:0071407 9.51 AKT1 CASP3
12 learning or memory GO:0007611 9.49 CASP3 PTEN
13 negative regulation of protein kinase B signaling GO:0051898 9.48 AKT1 PTEN
14 protein kinase B signaling GO:0043491 9.46 AKT1 PTEN
15 cellular response to nerve growth factor stimulus GO:1990090 9.43 AKT1 PTEN
16 regulation of neuron projection development GO:0010975 9.37 AKT1 PTEN
17 execution phase of apoptosis GO:0097194 9.32 AKT1 CASP3
18 striated muscle cell differentiation GO:0051146 9.26 AKT1 CASP3
19 negative regulation of cell size GO:0045792 9.16 AKT1 PTEN
20 response to organic substance GO:0010033 9.13 AKT1 CASP3 PTEN
21 cellular response to decreased oxygen levels GO:0036294 8.62 AKT1 PTEN

Sources for Pharynx Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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