MCID: PHR008
MIFTS: 28

Pharynx Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pharynx Squamous Cell Carcinoma

MalaCards integrated aliases for Pharynx Squamous Cell Carcinoma:

Name: Pharynx Squamous Cell Carcinoma 12 15

Classifications:



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Disease Ontology 12 DOID:0050921

Summaries for Pharynx Squamous Cell Carcinoma

Disease Ontology : 12 A pharynx cancer that has material basis in squamous cells.

MalaCards based summary : Pharynx Squamous Cell Carcinoma is related to squamous cell carcinoma and macroglossia. An important gene associated with Pharynx Squamous Cell Carcinoma is COL11A1 (Collagen Type XI Alpha 1 Chain), and among its related pathways/superpathways are Integrin Pathway and Focal Adhesion. Affiliated tissues include lung, brain and colon, and related phenotype is respiratory system.

Related Diseases for Pharynx Squamous Cell Carcinoma

Diseases related to Pharynx Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.2
2 macroglossia 10.1 COL11A1 PTEN
3 proteus syndrome 10.0 AKT1 PTEN
4 cowden syndrome 1 10.0 AKT1 PTEN
5 ocular hypertension 10.0 AKT1 PTEN
6 patulous eustachian tube 10.0
7 pleural cancer 10.0 AKT1 SMUG1
8 central nervous system cancer 10.0 AKT1 PTEN
9 thymus gland disease 10.0 AKT1 SMUG1
10 connective tissue cancer 10.0 AKT1 SMUG1
11 cowden disease 10.0 AKT1 PTEN
12 endometrial adenocarcinoma 9.9 AKT1 PTEN
13 autonomic nervous system neoplasm 9.9 AKT1 CASP3
14 peripheral nervous system neoplasm 9.9 AKT1 CASP3
15 toxic encephalopathy 9.9 AKT1 CASP3
16 anaplastic thyroid cancer 9.9 CASP3 PTEN
17 colonic disease 9.9 AKT1 CASP3
18 prostate disease 9.9 AKT1 PTEN
19 stomach disease 9.9 AKT1 CASP3
20 meningioma, familial 9.8 AKT1 PTEN SMUG1
21 suppression of tumorigenicity 12 9.8 AKT1 PTEN
22 tongue squamous cell carcinoma 9.8 AKT1 CASP3
23 male reproductive system disease 9.8 AKT1 CASP3 PTEN
24 supratentorial cancer 9.8 AKT1 CASP3 PTEN
25 cerebrum cancer 9.8 AKT1 CASP3 PTEN
26 male reproductive organ cancer 9.8 AKT1 CASP3 PTEN
27 nervous system cancer 9.7 AKT1 CASP3 PTEN
28 ovarian disease 9.7 AKT1 CASP3 PTEN
29 squamous cell carcinoma, head and neck 9.7 AKT1 CASP3 PTEN
30 brain cancer 9.7 AKT1 CASP3 PTEN
31 nasopharyngeal disease 9.7 AKT1 CASP3 SMUG1
32 pharynx cancer 9.7 AKT1 CASP3 SMUG1
33 cervix disease 9.7 AKT1 CASP3 SMUG1
34 medulloblastoma 9.7 AKT1 CASP3 PTEN
35 leukocyte disease 9.7 AKT1 CASP3 SMUG1
36 cervical cancer 9.7 AKT1 CASP3 PTEN
37 intestinal disease 9.7 AKT1 CASP3 SMUG1
38 respiratory system disease 9.7 AKT1 CASP3 SMUG1
39 gastrointestinal system disease 9.7 AKT1 CASP3 SMUG1
40 pancreas adenocarcinoma 9.7 AKT1 CASP3 SMUG1
41 nervous system disease 9.7 AKT1 CASP3 SMUG1
42 myeloma, multiple 9.7 AKT1 CASP3 SMUG1
43 thyroid cancer 9.7 AKT1 CASP3 PTEN
44 esophageal cancer 9.7 AKT1 CASP3 PTEN
45 endometrial cancer 9.6 AKT1 CASP3 PTEN
46 uterine anomalies 9.5 AKT1 CASP3 PTEN SMUG1
47 female reproductive system disease 9.5 AKT1 CASP3 PTEN SMUG1
48 reproductive system disease 9.5 AKT1 CASP3 PTEN SMUG1
49 respiratory system cancer 9.5 AKT1 CASP3 PTEN SMUG1
50 gastrointestinal system cancer 9.5 AKT1 CASP3 PTEN SMUG1

Graphical network of the top 20 diseases related to Pharynx Squamous Cell Carcinoma:



Diseases related to Pharynx Squamous Cell Carcinoma

Symptoms & Phenotypes for Pharynx Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Pharynx Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 8.92 AKT1 CASP3 COL11A1 PTEN

Drugs & Therapeutics for Pharynx Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Pharynx Squamous Cell Carcinoma

Genetic Tests for Pharynx Squamous Cell Carcinoma

Anatomical Context for Pharynx Squamous Cell Carcinoma

MalaCards organs/tissues related to Pharynx Squamous Cell Carcinoma:

41
Lung, Brain, Colon, Prostate, Pancreas, Thyroid, Thymus

Publications for Pharynx Squamous Cell Carcinoma

Articles related to Pharynx Squamous Cell Carcinoma:

# Title Authors Year
1
Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients. ( 30245069 )
2018
2
Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma. ( 15023835 )
2004

Variations for Pharynx Squamous Cell Carcinoma

Cosmic variations for Pharynx Squamous Cell Carcinoma:

9 (show top 50) (show all 553)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6970691 ZFHX3 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.3676C>T p.P1226S 16:72811765-72811765 7
2 COSM6961423 ZFHX3 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.10897C>T p.P3633S 16:72787379-72787379 7
3 COSM6958980 TSC2 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.3802C>G p.R1268G 16:2081786-2081786 7
4 COSM3277548 TSC2 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.3734G>A p.R1245Q 16:2081718-2081718 7
5 COSM6911446 TP63 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.1056G>T p.R352S 3:189868643-189868643 7
6 COSM6910538 TP63 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.1567C>T p.Q523* 3:189889399-189889399 7
7 COSM6932 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 7
8 COSM6549 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.743G>T p.R248L 17:7674220-7674220 7
9 COSM44151 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.535C>A p.H179N 17:7675077-7675077 7
10 COSM10662 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 7
11 COSM45653 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.281C>G p.S94* 17:7676088-7676088 7
12 COSM10725 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.701A>G p.Y234C 17:7674262-7674262 7
13 COSM10758 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 7
14 COSM10714 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.473G>T p.R158L 17:7675139-7675139 7
15 COSM10645 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 7
16 COSM11333 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.499C>T p.Q167* 17:7675113-7675113 7
17 COSM10660 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 7
18 COSM44571 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.581T>G p.L194R 17:7674950-7674950 7
19 COSM11196 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.734G>T p.G245V 17:7674229-7674229 7
20 COSM11780 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.338T>C p.F113S 17:7676031-7676031 7
21 COSM10905 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 7
22 COSM10701 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.824G>T p.C275F 17:7673796-7673796 7
23 COSM44329 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.470T>A p.V157D 17:7675142-7675142 7
24 COSM43714 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.836G>A p.G279E 17:7673784-7673784 7
25 COSM10659 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 7
26 COSM10867 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 7
27 COSM10889 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.536A>G p.H179R 17:7675076-7675076 7
28 COSM11286 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.1015G>T p.E339* 17:7670694-7670694 7
29 COSM10768 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 7
30 COSM44137 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.434T>A p.L145Q 17:7675178-7675178 7
31 COSM10834 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.711G>A p.M237I 17:7674252-7674252 7
32 COSM10667 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.646G>A p.V216M 17:7674885-7674885 7
33 COSM10812 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.722C>T p.S241F 17:7674241-7674241 7
34 COSM10648 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 7
35 COSM10656 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 7
36 COSM11244 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.764T>A p.I255N 17:7674199-7674199 7
37 COSM45367 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.672+1G>C p.? 17:7674858-7674858 7
38 COSM44346 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.875A>C p.K292T 17:7673745-7673745 7
39 COSM10704 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 7
40 COSM10813 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.394A>G p.K132E 17:7675218-7675218 7
41 COSM44472 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.922C>A p.L308M 17:7673606-7673606 7
42 COSM43778 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.713G>T p.C238F 17:7674250-7674250 7
43 COSM44171 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.840A>T p.R280S 17:7673780-7673780 7
44 COSM11524 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.730G>T p.G244C 17:7674233-7674233 7
45 COSM44093 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.644G>A p.S215N 17:7674887-7674887 7
46 COSM45589 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.1037A>C p.E346A 17:7670672-7670672 7
47 COSM69404 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.994-1G>A p.? 17:7670716-7670716 7
48 COSM45243 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.374C>G p.T125R 17:7675995-7675995 7
49 COSM10943 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.841G>C p.D281H 17:7673779-7673779 7
50 COSM43606 TP53 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.734G>A p.G245D 17:7674229-7674229 7

Expression for Pharynx Squamous Cell Carcinoma

Search GEO for disease gene expression data for Pharynx Squamous Cell Carcinoma.

Pathways for Pharynx Squamous Cell Carcinoma

Pathways related to Pharynx Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 AKT1 CASP3 COL11A1 PTEN
2
Show member pathways
12.6 AKT1 COL11A1 PTEN
3
Show member pathways
12.56 AKT1 CASP3 PTEN
4 12.53 AKT1 CASP3 PTEN
5
Show member pathways
12.39 AKT1 CASP3 PTEN
6
Show member pathways
12.33 AKT1 CASP3 PTEN
7
Show member pathways
12.08 AKT1 CASP3 PTEN
8
Show member pathways
11.79 AKT1 CASP3 PTEN
9
Show member pathways
11.77 AKT1 CASP3 PTEN
10 11.7 AKT1 CASP3 PTEN
11 11.66 AKT1 CASP3
12 11.63 AKT1 CASP3
13 11.63 AKT1 PTEN
14 11.62 AKT1 PTEN
15 11.62 AKT1 CASP3 PTEN
16 11.58 AKT1 PTEN
17
Show member pathways
11.57 AKT1 CASP3
18
Show member pathways
11.56 AKT1 CASP3
19 11.49 AKT1 CASP3
20 11.44 AKT1 CASP3
21
Show member pathways
11.44 AKT1 CASP3
22 11.43 AKT1 PTEN
23 11.42 AKT1 PTEN
24 11.41 AKT1 CASP3
25 11.35 AKT1 CASP3
26 11.31 AKT1 PTEN
27 11.3 AKT1 CASP3 PTEN
28 11.26 AKT1 CASP3
29 11.14 AKT1 CASP3
30 11.03 AKT1 CASP3
31 11 AKT1 PTEN
32 10.99 AKT1 PTEN
33 10.95 AKT1 PTEN
34 10.86 AKT1 CASP3 PTEN
35 10.77 AKT1 CASP3
36 10.46 AKT1 CASP3 PTEN

GO Terms for Pharynx Squamous Cell Carcinoma

Biological processes related to Pharynx Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.72 AKT1 CASP3 PTEN
2 cellular response to DNA damage stimulus GO:0006974 9.69 AKT1 CASP3 SMUG1
3 positive regulation of apoptotic process GO:0043065 9.63 AKT1 CASP3 PTEN
4 response to estradiol GO:0032355 9.57 CASP3 PTEN
5 cellular response to insulin stimulus GO:0032869 9.56 AKT1 PTEN
6 response to glucose GO:0009749 9.54 CASP3 PTEN
7 cellular response to organic cyclic compound GO:0071407 9.52 AKT1 CASP3
8 learning or memory GO:0007611 9.49 CASP3 PTEN
9 negative regulation of protein kinase B signaling GO:0051898 9.48 AKT1 PTEN
10 protein kinase B signaling GO:0043491 9.43 AKT1 PTEN
11 cellular response to nerve growth factor stimulus GO:1990090 9.4 AKT1 PTEN
12 regulation of neuron projection development GO:0010975 9.37 AKT1 PTEN
13 execution phase of apoptosis GO:0097194 9.32 AKT1 CASP3
14 striated muscle cell differentiation GO:0051146 9.26 AKT1 CASP3
15 negative regulation of cell size GO:0045792 9.16 AKT1 PTEN
16 response to organic substance GO:0010033 9.13 AKT1 CASP3 PTEN
17 cellular response to decreased oxygen levels GO:0036294 8.62 AKT1 PTEN

Sources for Pharynx Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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