MCID: PHR008
MIFTS: 16

Pharynx Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pharynx Squamous Cell Carcinoma

MalaCards integrated aliases for Pharynx Squamous Cell Carcinoma:

Name: Pharynx Squamous Cell Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050921

Summaries for Pharynx Squamous Cell Carcinoma

Disease Ontology : 12 A pharynx cancer that has material basis in squamous cells.

MalaCards based summary : Pharynx Squamous Cell Carcinoma is related to squamous cell carcinoma and malignant fibrous histiocytoma. An important gene associated with Pharynx Squamous Cell Carcinoma is COL11A1 (Collagen Type XI Alpha 1 Chain), and among its related pathways/superpathways is Signaling events mediated by PRL. Affiliated tissues include lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Pharynx Squamous Cell Carcinoma

Diseases related to Pharynx Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.3
2 malignant fibrous histiocytoma 9.9 RECQL4 MFHAS1
3 tongue disease 9.9 MIR196A1 MAU2
4 retinal cancer 9.6 MIR196A1 CDKN2D

Symptoms & Phenotypes for Pharynx Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Pharynx Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-1 9.87 COL11A1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.87 MFHAS1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.87 MFHAS1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.87 COL11A1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.87 TUSC3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-15 9.87 COL11A1 MFHAS1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.87 TUSC3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.87 COL11A1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-179 9.87 COL11A1 RECQL4
10 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.87 COL11A1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.87 COL11A1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.87 TUSC3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.87 COL11A1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.87 COL11A1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.87 COL11A1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.87 TUSC3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.87 COL11A1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.87 MFHAS1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.87 RECQL4
20 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.87 COL11A1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.87 TUSC3

MGI Mouse Phenotypes related to Pharynx Squamous Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.56 CDKN2D COL11A1 DND1 MAU2 PTP4A3 RABGGTA
2 neoplasm MP:0002006 8.92 CDKN2D DND1 PTP4A3 RECQL4

Drugs & Therapeutics for Pharynx Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Pharynx Squamous Cell Carcinoma

Genetic Tests for Pharynx Squamous Cell Carcinoma

Anatomical Context for Pharynx Squamous Cell Carcinoma

MalaCards organs/tissues related to Pharynx Squamous Cell Carcinoma:

40
Lymph Node

Publications for Pharynx Squamous Cell Carcinoma

Articles related to Pharynx Squamous Cell Carcinoma:

# Title Authors PMID Year
1
Stroma-Rich Co-Culture Multicellular Tumor Spheroids as a Tool for Photoactive Drugs Screening. 61
31618880 2019
2
Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients. 61
30245069 2018
3
Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. 61
23909904 2013
4
Chromosomal changes in relation to clinical outcome in larynx and pharynx squamous cell carcinoma. 61
16037640 2005
5
[Study on loss of heterozygosity at microsatellite locus in larynx and pharynx squamous cell carcinoma and neck lymph nodes]. 61
15354767 2004
6
Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma. 61
15023835 2004
7
Composite resection with mandibulectomy in the treatment of posterolateral oral cavity and lateral oropharynx squamous cell carcinoma. 61
8214310 1993

Variations for Pharynx Squamous Cell Carcinoma

Cosmic variations for Pharynx Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122735929 upper aerodigestive tract,pharynx,carcinoma,squamous cell carcinoma c.218A>G p.Y73C 17:7674917-7674917 0

Expression for Pharynx Squamous Cell Carcinoma

Search GEO for disease gene expression data for Pharynx Squamous Cell Carcinoma.

Pathways for Pharynx Squamous Cell Carcinoma

Pathways related to Pharynx Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.98 RABGGTA PTP4A3

GO Terms for Pharynx Squamous Cell Carcinoma

Sources for Pharynx Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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