MCID: PHN001
MIFTS: 24

Phencyclidine Abuse

Categories: Mental diseases

Aliases & Classifications for Phencyclidine Abuse

MalaCards integrated aliases for Phencyclidine Abuse:

Name: Phencyclidine Abuse 12 43 15 17 71
Pcp Abuse 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5062
MeSH 43 D010623
SNOMED-CT 67 7071007
UMLS 71 C0031391

Summaries for Phencyclidine Abuse

Disease Ontology : 12 A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences.

MalaCards based summary : Phencyclidine Abuse, also known as pcp abuse, is related to ocular motor apraxia and substance abuse. An important gene associated with Phencyclidine Abuse is SEMA3B (Semaphorin 3B), and among its related pathways/superpathways are Vesicle-mediated transport and Signal transduction_Erk Interactions- Inhibition of Erk. Affiliated tissues include brain, kidney and testes.

Related Diseases for Phencyclidine Abuse

Diseases related to Phencyclidine Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 ocular motor apraxia 10.2
2 substance abuse 10.1
3 yemenite deaf-blind hypopigmentation syndrome 10.0
4 alcohol use disorder 10.0
5 acute kidney failure 10.0
6 kidney disease 10.0
7 drug dependence 10.0
8 depression 10.0
9 head injury 10.0
10 alcohol dependence 10.0
11 withdrawal disorder 10.0

Graphical network of the top 20 diseases related to Phencyclidine Abuse:



Diseases related to Phencyclidine Abuse

Symptoms & Phenotypes for Phencyclidine Abuse

Drugs & Therapeutics for Phencyclidine Abuse

Search Clinical Trials , NIH Clinical Center for Phencyclidine Abuse

Cochrane evidence based reviews: phencyclidine abuse

Genetic Tests for Phencyclidine Abuse

Anatomical Context for Phencyclidine Abuse

MalaCards organs/tissues related to Phencyclidine Abuse:

40
Brain, Kidney, Testes, Liver, Fetal Brain

Publications for Phencyclidine Abuse

Articles related to Phencyclidine Abuse:

(show top 50) (show all 75)
# Title Authors PMID Year
1
Subchronic treatment with phencyclidine in adolescence leads to impaired exploratory behavior in adult rats without altering social interaction or N-methyl-D-aspartate receptor binding levels. 61
24953757 2014
2
Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test. 61
22147257 2012
3
Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen. 61
21373301 2010
4
[Phencyclidine abuse, dependence, intoxication, and psychosis]. 61
20715485 2010
5
Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. 61
17205118 2006
6
Airway effects of marijuana, cocaine, and other inhaled illicit agents. 61
11224724 2001
7
Differential and region-specific activation of mitogen-activated protein kinases following chronic administration of phencyclidine in rat brain. 61
11166517 2001
8
Nitric oxide synthase inhibitors attenuate phencyclidine-induced disruption of prepulse inhibition. 61
9608580 1998
9
Functional changes in neuronal systems induced by phencyclidine administration. 61
8959021 1996
10
Detection of phencyclidine in urine using a polarization fluoroimmunoassay. 61
7978326 1994
11
Phencyclidine. 61
2201519 1990
12
Magnesium ions prevent phencyclidine-induced cerebrovasospasms and rupture of cerebral microvessels: direct in-vivo microcirculatory studies on the rat brain. 61
2366950 1990
13
Phencyclidine and violent deaths in St. Louis, Missouri: a survey of medical examiners' cases from 1977 through 1986. 61
2288325 1990
14
Short-term memory impairment in cannabis-dependent adolescents. 61
2801665 1989
15
A review of PCP abuse trends and perceptions. 61
2502802 1989
16
Effects of gestational exposure to phencyclidine: distribution and neurochemical alterations in maternal and fetal brain. 61
2576301 1989
17
Outpatient treatment of PCP abusers. 61
2596441 1989
18
Inpatient treatment of PCP abusers and users. 61
2923107 1989
19
Phencyclidine and violence: clinical and legal issues. 61
3069880 1988
20
Treatment of Phencyclidine-Associated Psychosis with ECT. 61
11940970 1988
21
Pathological and radiological correlation of subarachnoid hemorrhage in phencyclidine abuse. Case report. 61
3612276 1987
22
Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse. 61
3441016 1987
23
PCP abuse in New Orleans: a six-year study. 61
3318397 1987
24
Clinical aspects of phencyclidine (PCP). 61
3549584 1987
25
Phencyclidine in CSF and serum: a case of attempted filicide by a mother without a history of substance abuse. 61
3733677 1986
26
Identification and quantification of phencyclidine pyrolysis products formed during smoking. 61
3724075 1986
27
Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine. 61
3514688 1986
28
Phencyclidine (PCP) abuse. A close-up look at a growing problem. 61
2938052 1986
29
Clinical implications of behavioral pharmacology research on phencyclidine. 61
3086731 1986
30
Diagnosis and treatment of chronic phencyclidine (PCP) abuse. 61
3086736 1986
31
Legal issues associated with PCP abuse--the role of the forensic expert. 61
3086737 1986
32
Drug abuse among state hospital psychiatric inpatients with particular reference to PCP. 61
4019423 1985
33
Phencyclidine abuse in New Zealand. 61
6591044 1984
34
Phencyclidine-induced malignant hyperthermia causing submassive liver necrosis. 61
6741977 1984
35
Phencyclidine-induced immunodepression. 61
6328664 1984
36
The efficacy of ECT in phencyclidine-induced psychosis. 61
6144671 1984
37
Phencyclidine abuse and depression. 61
6647724 1983
38
Disposition of phencyclidine and its pyrolytic products in mice exposed to smoke. 61
6852274 1983
39
Interactions between phencyclidine and delta 9-tetrahydrocannabinol in mice following smoke exposure. 61
6298542 1983
40
Chronic phencyclidine abuse and physical assault. 61
7149062 1982
41
Intracranial hemorrhage associated with phencyclidine abuse. 61
7097906 1982
42
Phencyclidine abuse and crime: a psychiatric perspective. 61
7159767 1982
43
Neonatal manifestations of maternal phencyclidine (PCP) abuse. 61
7322687 1981
44
Psychiatric and medical syndromes associated with phencyclidine (PCP) abuse. 61
6109037 1981
45
Myoglobinuric acute renal failure in phencyclidine overdose: report of observations in eight cases. 61
7436062 1980
46
A clinical approach to the treatment of phencyclidine (PCP) abuse [proceedings]. 61
7454943 1980
47
Chronic phencyclidine (PCP) abuse: a psychiatric perspective--Part I: General aspects and violence [proceedings]. 61
7454944 1980
48
Chronic phenycyclidine (PCP) abuse: a psychiatric perspective--Part II: Psychosis [proceedings]. 61
7454945 1980
49
Issues for inpatient treatment of chronic PCP abuse. 61
7431426 1980
50
Epidemiology of PCP abuse: the Midwest perspective. 61
7431417 1980

Variations for Phencyclidine Abuse

Expression for Phencyclidine Abuse

Search GEO for disease gene expression data for Phencyclidine Abuse.

Pathways for Phencyclidine Abuse

Pathways related to Phencyclidine Abuse according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 VPS37C GCC1 CALM2 APOL1
2 10.82 PTPN5 CALM2
3 9.9 APOL2 APOL1

GO Terms for Phencyclidine Abuse

Biological processes related to Phencyclidine Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol metabolic process GO:0008203 9.16 APOL2 APOL1
2 protein targeting to membrane GO:0006612 8.96 ZDHHC1 VPS37C
3 lipoprotein metabolic process GO:0042157 8.62 APOL2 APOL1

Sources for Phencyclidine Abuse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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