MCID: PHN001
MIFTS: 34

Phencyclidine Abuse

Categories: Mental diseases

Aliases & Classifications for Phencyclidine Abuse

MalaCards integrated aliases for Phencyclidine Abuse:

Name: Phencyclidine Abuse 12 45 15 17 74
Pcp Abuse 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5062
MeSH 45 D010623
SNOMED-CT 69 7071007
UMLS 74 C0031391

Summaries for Phencyclidine Abuse

Disease Ontology : 12 A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences.

MalaCards based summary : Phencyclidine Abuse, also known as pcp abuse, is related to long qt syndrome 1 and long qt syndrome 15. An important gene associated with Phencyclidine Abuse is CALM2 (Calmodulin 2), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Phencyclidine Abuse

Diseases related to Phencyclidine Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 long qt syndrome 1 10.2 CALM1 CALM2 CALM3
2 long qt syndrome 15 10.2 CALM1 CALM2 CALM3
3 otomycosis 10.2 CALM1 CALM2 CALM3
4 external ear disease 10.2 CALM1 CALM2 CALM3
5 emery-dreifuss muscular dystrophy 5, autosomal dominant 10.2 CALM1 CALM2 CALM3
6 sporotrichosis 10.2 CALM1 CALM2 CALM3
7 depression 10.2
8 otitis externa 10.2 CALM1 CALM2 CALM3
9 spontaneous ocular nystagmus 10.2 CALM1 CALM2 CALM3
10 deafness, autosomal recessive 44 10.2 CALM1 CALM2 CALM3
11 acute dacryocystitis 10.2 CALM1 CALM2 CALM3
12 dystonia 24 10.2 CALM1 CALM2 CALM3
13 gestational choriocarcinoma 10.2 CALM1 CALM2 CALM3
14 triosephosphate isomerase deficiency 10.2 CALM1 CALM2 CALM3
15 leber congenital amaurosis 2 10.2 CALM1 CALM2 CALM3
16 tinea unguium 10.2 CALM1 CALM2 CALM3
17 primary systemic mycosis 10.2 CALM1 CALM2 CALM3
18 clear cell acanthoma 10.1 CALM1 CALM2 CALM3
19 cardiomyopathy, dilated, 1a 10.1 CALM1 CALM2 CALM3
20 cardiomyopathy, dilated, 1p 10.1 CALM1 CALM2 CALM3
21 phaeohyphomycosis 10.1 CALM1 CALM2 CALM3
22 deafness, autosomal dominant 2a 10.1 CALM1 CALM2 CALM3
23 microcephaly 2, primary, autosomal recessive, with or without cortical malformations 10.1 CALM1 CALM2 CALM3
24 head injury 10.1
25 ceroid lipofuscinosis, neuronal, 11 10.0 CALM1 CALM2 CALM3
26 primary cutaneous amyloidosis 10.0 CALM1 CALM2 CALM3
27 catecholaminergic polymorphic ventricular tachycardia 10.0 CALM1 CALM2 CALM3
28 cardiac arrest 9.8 CALM1 CALM2 CALM3

Graphical network of the top 20 diseases related to Phencyclidine Abuse:



Diseases related to Phencyclidine Abuse

Symptoms & Phenotypes for Phencyclidine Abuse

GenomeRNAi Phenotypes related to Phencyclidine Abuse according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.91 CAMK2B
2 Decreased viability GR00173-A 9.91 CALM2
3 Decreased viability GR00221-A-1 9.91 CALM2 CAMK2B
4 Decreased viability GR00221-A-2 9.91 CALM1 CALM2
5 Decreased viability GR00221-A-3 9.91 CALM1
6 Decreased viability GR00221-A-4 9.91 CALM1 CALM2
7 Decreased viability GR00301-A 9.91 CALM1 CALM2 CAMK2B ERBB4
8 Decreased viability GR00342-S-1 9.91 ERBB4
9 Decreased viability GR00402-S-2 9.91 CALM1 CALM2 CAMK2B ERBB4
10 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 9.33 CALM2 CALM3 ERBB4
11 Reduced mammosphere formation GR00396-S 9.17 CALM1 CALM2 CALM3 CAMK2B FDFT1 GRIN2B

Drugs & Therapeutics for Phencyclidine Abuse

Search Clinical Trials , NIH Clinical Center for Phencyclidine Abuse

Cochrane evidence based reviews: phencyclidine abuse

Genetic Tests for Phencyclidine Abuse

Anatomical Context for Phencyclidine Abuse

Publications for Phencyclidine Abuse

Articles related to Phencyclidine Abuse:

(show all 40)
# Title Authors Year
1
Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. ( 17205118 )
2006
2
A review of PCP abuse trends and perceptions. ( 2502802 )
1989
3
Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse. ( 3441016 )
1987
4
Pathological and radiological correlation of subarachnoid hemorrhage in phencyclidine abuse. Case report. ( 3612276 )
1987
5
PCP abuse in New Orleans: a six-year study. ( 3318397 )
1987
6
Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine. ( 3514688 )
1986
7
Phencyclidine (PCP) abuse. A close-up look at a growing problem. ( 2938052 )
1986
8
Diagnosis and treatment of chronic phencyclidine (PCP) abuse. ( 3086736 )
1986
9
Legal issues associated with PCP abuse--the role of the forensic expert. ( 3086737 )
1986
10
Phencyclidine abuse in New Zealand. ( 6591044 )
1984
11
Phencyclidine abuse and depression. ( 6647724 )
1983
12
Intracranial hemorrhage associated with phencyclidine abuse. ( 7097906 )
1982
13
Chronic phencyclidine abuse and physical assault. ( 7149062 )
1982
14
Phencyclidine abuse and crime: a psychiatric perspective. ( 7159767 )
1982
15
Psychiatric and medical syndromes associated with phencyclidine (PCP) abuse. ( 6109037 )
1981
16
Neonatal manifestations of maternal phencyclidine (PCP) abuse. ( 7322687 )
1981
17
Phencyclidine abuse in New Orleans: medical, forensic, and laboratory aspects. ( 7347922 )
1980
18
Phencyclidine abuse mimicking head injury. ( 7373800 )
1980
19
Violence and PCP abuse. ( 7377414 )
1980
20
Epidemiology of PCP abuse: the Midwest perspective. ( 7431417 )
1980
21
Issues for inpatient treatment of chronic PCP abuse. ( 7431426 )
1980
22
PCP abuse: diagnostic and psychopharmacological treatment approaches. ( 7431428 )
1980
23
Chronic phencyclidine (PCP) abuse: a psychiatric perspective. ( 7431430 )
1980
24
A clinical approach to the treatment of phencyclidine (PCP) abuse [proceedings]. ( 7454943 )
1980
25
Chronic phencyclidine (PCP) abuse: a psychiatric perspective--Part I: General aspects and violence [proceedings]. ( 7454944 )
1980
26
Chronic phenycyclidine (PCP) abuse: a psychiatric perspective--Part II: Psychosis [proceedings]. ( 7454945 )
1980
27
Phencyclidine abuse. Clinical findings and concentrations in biological fluids after nonfatal intoxication. ( 506993 )
1979
28
Violence associated with phencyclidine abuse. ( 507211 )
1979
29
Case report: symptomatic mania and phencyclidine abuse. ( 758819 )
1979
30
Myoglobinuric acute renal failure associated with phencyclidine abuse. ( 18748486 )
1979
31
The paradox of phencyclidine (PCP) abuse. ( 426413 )
1979
32
Is phencyclidine (PCP) abuse associated with organic mental impairment?. ( 539570 )
1979
33
Phenomenological aspects of phencyclidine abuse among ethnic groups in Hawaii. ( 101869 )
1978
34
Hypertensive crisis and phencyclidine abuse. ( 685417 )
1978
35
The diagnosis and treatment of the PCP abuse syndrome. ( 101871 )
1978
36
PCP abuse. ( 661052 )
1978
37
Phencyclidine abuse and symptomatic mania. ( 588649 )
1977
38
Notes on Alcoholism and Drug Abuse: Phencyclidine (PCP) Abuse. ( 18748001 )
1977
39
Psychiatric sequelae of phencyclidine abuse. ( 10126 )
1976
40
Out-patient clinical experience in a community drug abuse program with phencyclidine abuse. ( 975755 )
1976

Variations for Phencyclidine Abuse

Expression for Phencyclidine Abuse

Search GEO for disease gene expression data for Phencyclidine Abuse.

Pathways for Phencyclidine Abuse

Pathways related to Phencyclidine Abuse according to GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CALM1 CALM2 CALM3 ERBB4 F2 GRIN2B
2
Show member pathways
13.57 CALM1 CALM2 CALM3 CAMK2B ERBB4 F2
3
Show member pathways
13.51 CALM1 CALM2 CALM3 CAMK2B ERBB4 GRIN2B
4
Show member pathways
13.43 CALM1 CALM2 CALM3 CAMK2B F2 JUN
5
Show member pathways
13.35 CALM1 CALM2 CALM3 CAMK2B ERBB4 GRIN2B
6
Show member pathways
13.24 CALM1 CALM2 CALM3 CAMK2B ERBB4 JUN
7
Show member pathways
13.04 CALM1 CALM2 CALM3 HTR2A JUN
8
Show member pathways
13.04 CALM1 CALM2 CALM3 CAMK2B GRIN2B JUN
9
Show member pathways
13.03 CALM1 CALM2 CALM3 CAMK2B GRIN2B JUN
10
Show member pathways
13.02 CALM1 CALM2 CALM3 CAMK2B GRIN2B
11
Show member pathways
13 CALM1 CALM2 CALM3 ERBB4 JUN
12
Show member pathways
13 CALM1 CALM2 CALM3 CAMK2B SCARB1
13
Show member pathways
12.99 CALM1 CALM2 CALM3 CAMK2B JUN MAP2K7
14
Show member pathways
12.97 CALM1 CALM2 CALM3 JUN MAP2K7
15
Show member pathways
12.96 CALM1 CALM2 CALM3 CAMK2B F2 JUN
16
Show member pathways
12.95 CALM1 CALM2 CALM3 CAMK2B JUN MAP2K7
17 12.87 CALM1 CALM2 CALM3 CAMK2B JUN
18
Show member pathways
12.81 CALM1 CALM2 CALM3 CAMK2B ERBB4 JUN
19
Show member pathways
12.78 CALM1 CALM2 CALM3 CAMK2B JUN
20
Show member pathways
12.72 CALM1 CALM2 CALM3 CAMK2B JUN MAP2K7
21
Show member pathways
12.72 CALM1 CALM2 CALM3 CAMK2B JUN MAP2K7
22
Show member pathways
12.7 CALM1 CALM2 CALM3 CAMK2B F2
23
Show member pathways
12.66 CALM1 CALM2 CALM3 JUN MAP2K7
24
Show member pathways
12.63 CALM1 CALM2 CALM3 CAMK2B JUN MAP2K7
25
Show member pathways
12.62 CALM1 CALM2 CALM3 JUN MAP2K7
26
Show member pathways
12.61 CAMK2B ERBB4 JUN MAP2K7
27
Show member pathways
12.61 CALM1 CALM2 CALM3 CAMK2B JUN
28 12.6 CALM1 CAMK2B GRIN2B SEMA3B
29
Show member pathways
12.59 CALM1 CALM2 JUN MAP2K7
30
Show member pathways
12.57 CALM1 CALM2 CALM3 CAMK2B HTR2A JUN
31
Show member pathways
12.56 CALM1 CALM2 CALM3 CAMK2B
32
Show member pathways
12.56 CALM1 CALM2 CALM3 CAMK2B
33
Show member pathways
12.56 CALM1 CALM2 CALM3 CAMK2B JUN
34
Show member pathways
12.55 CAMK2B ERBB4 JUN MAP2K7
35
Show member pathways
12.53 CALM1 CALM2 CALM3 JUN
36
Show member pathways
12.51 CALM1 CALM2 CALM3 JUN
37
Show member pathways
12.43 CALM1 CALM2 CALM3 JUN
38
Show member pathways
12.42 CALM1 CALM2 CALM3 JUN
39 12.4 CALM1 CALM2 CALM3 GRIN2B
40
Show member pathways
12.39 CALM1 CALM2 CALM3 CAMK2B
41
Show member pathways
12.36 CALM1 CALM2 CALM3 CAMK2B
42
Show member pathways
12.34 CALM1 CALM2 CALM3 JUN
43
Show member pathways
12.33 CALM1 CALM2 CALM3 CAMK2B JUN
44
Show member pathways
12.31 CALM1 CALM2 CALM3 CAMK2B JUN MAP2K7
45 12.27 CALM1 CALM2 CALM3 CAMK2B
46
Show member pathways
12.25 CALM1 CALM2 CALM3 JUN
47
Show member pathways
12.25 CALM1 CALM2 CALM3 F2 JUN MAP2K7
48
Show member pathways
12.23 CALM1 CALM2 CALM3 CAMK2B
49
Show member pathways
12.23 CALM1 CALM2 CALM3 CAMK2B GRIN2B
50
Show member pathways
12.21 CALM1 CALM2 CALM3 F2

GO Terms for Phencyclidine Abuse

Cellular components related to Phencyclidine Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
2 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
3 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
4 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
5 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Phencyclidine Abuse according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 9.83 APOL1 APOL2 SCARB1
2 cholesterol metabolic process GO:0008203 9.81 APOL1 APOL2 FDFT1
3 MAPK cascade GO:0000165 9.8 CALM1 ERBB4 GRIN2B
4 response to calcium ion GO:0051592 9.8 CALM1 CALM2 CALM3
5 regulation of synaptic vesicle exocytosis GO:2000300 9.79 CALM1 CALM3 HTR2A
6 positive regulation of protein serine/threonine kinase activity GO:0071902 9.78 CALM1 CALM2 CALM3
7 substantia nigra development GO:0021762 9.77 CALM1 CALM2 CALM3
8 regulation of cytokinesis GO:0032465 9.76 CALM1 CALM2 CALM3
9 calcium-mediated signaling GO:0019722 9.76 CALM1 CALM2 CALM3 GRIN2B
10 regulation of heart rate GO:0002027 9.75 CALM1 CALM2 CALM3
11 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.74 CALM1 CALM2 CALM3
12 positive regulation of protein dephosphorylation GO:0035307 9.72 CALM1 CALM2 CALM3
13 positive regulation of protein autophosphorylation GO:0031954 9.71 CALM1 CALM2 CALM3
14 positive regulation of nitric-oxide synthase activity GO:0051000 9.7 CALM1 CALM3 SCARB1
15 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.69 CALM1 CALM2 CALM3
16 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.67 CALM1 CALM2 CALM3
17 response to corticosterone GO:0051412 9.65 CALM1 CALM3
18 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.65 CALM1 CALM3
19 regulation of cardiac muscle contraction GO:0055117 9.65 CALM1 CALM2 CALM3
20 regulation of synaptic vesicle endocytosis GO:1900242 9.64 CALM1 CALM3
21 establishment of protein localization to membrane GO:0090150 9.63 CALM1 CALM3
22 regulation of high voltage-gated calcium channel activity GO:1901841 9.62 CALM1 CALM3
23 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
24 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
25 establishment of protein localization to mitochondrial membrane GO:0090151 9.56 CALM1 CALM3
26 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
27 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
28 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
29 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
30 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
31 positive regulation by host of symbiont cAMP-mediated signal transduction GO:0075206 8.8 CALM1 CALM2 CALM3
32 phosphorylation GO:0016310 10.08 CALM1 CALM2 CALM3 CAMK2B ERBB4 MAP2K7

Molecular functions related to Phencyclidine Abuse according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.93 CALM1 CALM2 CALM3 CAMK2B ERBB4 MAP2K7
2 ion channel binding GO:0044325 9.71 CALM1 CALM2 CALM3
3 disordered domain specific binding GO:0097718 9.61 CALM1 CALM2 CALM3
4 protein serine/threonine kinase activator activity GO:0043539 9.58 CALM1 CALM2 CALM3
5 phosphatidylinositol 3-kinase binding GO:0043548 9.55 CALM1 CALM3
6 nitric-oxide synthase binding GO:0050998 9.52 CALM1 CALM3
7 calcium channel inhibitor activity GO:0019855 9.51 CALM1 CALM2
8 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
9 high-density lipoprotein particle binding GO:0008035 9.49 APOL2 SCARB1
10 nitric-oxide synthase regulator activity GO:0030235 9.48 CALM1 CALM3
11 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
12 type 3 metabotropic glutamate receptor binding GO:0031800 9.37 CALM1 CALM3
13 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
14 adenylate cyclase activator activity GO:0010856 9.13 CALM1 CALM2 CALM3
15 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Phencyclidine Abuse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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